Patents Issued in March 17, 2020
  • Patent number: 10588963
    Abstract: The invention relates to the fields of immunology and vaccinology. Provided is a method for preparing adjuvanted virosomes, comprising the steps of: (i) providing an aqueous composition of non-adjuvanted virosomes comprising a membrane fusion protein; (ii) dissolving an amphiphilic adjuvant in a pharmaceutically acceptable non-aqueous solvent which can form a homogeneous mixture with water; and (iii) diluting said adjuvant solution in said aqueous virosome composition to induce insertion of adjuvant in the outer leaflet of the virosomal membrane while preserving membrane fusion activity of the virosomes. Also provided are adjuvanted virosomes obtainable by said method, and vaccines comprising the virosomes.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: March 17, 2020
    Assignee: BESTEWIL HOLDING B.V.
    Inventors: Antonius Johannes Henrikus Stegmann, Joan Claudia Maureen Soei-Ken Tjon
  • Patent number: 10588964
    Abstract: The invention features vaccine adjuvants comprising prokaryotic mRNA, and methods of vaccination using the adjuvants.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: March 17, 2020
    Assignee: Cornell University
    Inventors: Julie Magarian Blander, Leif Erik Sander
  • Patent number: 10588965
    Abstract: The invention concerns nutritional compositions with fucosyllactose for use in stimulation of NK cells. The composition is suitable for infants.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: March 17, 2020
    Assignee: N.V. Nutricia
    Inventors: Bernd Stahl, Alma Jildou Nauta, Johan Garssen, Eric Samain, Sophie Drouillard
  • Patent number: 10588966
    Abstract: Compounds and compositions for selectively inhibiting Akt3 are provided. Methods of using the compounds are also provided. Because Akt3 modulates the suppressive function of natural Tregs and the polarization of induced Tregs, the disclosed compounds are useful for modulating immune responses.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: March 17, 2020
    Assignee: Augusta University Research Institute, Inc.
    Inventors: Samir N. Khleif, Mikayel Mkrtichyan
  • Patent number: 10588967
    Abstract: The present invention relates to a chimeric antigen receptor (CAR) signalling system comprising; (i) a receptor component comprising an extracellular antigen-binding domain, a transmembrane domain and a intracellular first chemical inducer of dimerization binding domain 1 (CBD1); and (ii) an intracellular signalling component comprising a signalling domain and a second chemical inducer of dimerization binding domain 2 (CBD2); wherein CBD1 and CBD2 are capable of simultaneously binding to a chemical inducer of dimerization (CID); wherein, in the absence of the CID, binding of the antigen-binding component to antigen does not result in signalling through the signalling component; whilst, in the presence of the CID, the receptor component and the signalling component heterodimerize and binding of the antigen-binding domain to antigen results in signalling through the signalling domain.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: March 17, 2020
    Assignee: UCL BUSINESS LTD
    Inventors: Martin Pulé, Shaun Cordoba, Khai Kong
  • Patent number: 10588968
    Abstract: The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: March 17, 2020
    Assignee: KADMON CORPORATION, LLC
    Inventors: Dan Lu, Zhenping Zhu
  • Patent number: 10588969
    Abstract: This disclosure provides IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof. In certain aspects the anti-IL-21 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects the binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof provided herein inhibit, suppress, or antagonize IL-21 activity. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders, e.g., inflammatory, immune-mediated, or autoimmune diseases or disorders associated with IL-21-mediated signal transduction. In a particular embodiment, the disclosure provides methods for treating or preventing Graft-versus-host disease (GVHD) using IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: March 17, 2020
    Assignee: Boston Pharmaceuticals, Inc.
    Inventors: Catherine Ettinger, Jodi Karnell, Melissa Damschroder, Partha Chowdhury, Xiaodong Xiao, Ping Tsui, Reena Varkey, Stacey Drabic, Laura Carter, Ronald Herbst, Qun Du, Brian Michael Naiman
  • Patent number: 10588970
    Abstract: Embodiments described herein relate to restorative solutions for segmental peripheral nerve (PN) defects using allografted PNs for stimulating PN repair. More specifically, embodiments described herein provide for localized immunosuppression (LIS) surrounding PN allografts as an alternative to systemically suppressing a patient's entire immune system. Methods include localized release of immunosuppressive (ISV) agents are contemplated in one embodiment. Methods also include localized application of immunosuppressive (ISV) regulatory T-cells (Tregs) in other embodiments. Hydrogel carrier materials for delivery of ISV agents and are also described herein.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: March 17, 2020
    Assignee: UNIVERSITY OF WYOMING
    Inventor: Jared Bushman
  • Patent number: 10588971
    Abstract: The present invention relates to methods and compositions for use in modulating, including inhibiting the growth and/or reducing the virulence of, gram-positive bacteria. The present invention provides methods and compositions for disrupting the cell wall and/or cell membrane in gram-positive bacteria such that cell wall or cell membrane target(s) are rendered exposed or accessible and sensitive to a modulation thereof. Methods for modulation of one or more gram-positive bacterial cell wall or cell membrane targets in a gram-positive bacteria are provided comprising disrupting the cell wall such that the cell wall or cell membrane target, which is particularly a sortase, is rendered exposed or accessible and sensitive to a modifying, modulating or binding agent, which is particularly an antibody or fragment thereof, wherein the cell wall or cell membrane target is inaccessible or relatively insensitive to the modifying, modulating or binding agent in the absence of cell wall disruption.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: March 17, 2020
    Assignee: The Rockefeller University
    Inventors: Robert C. Nowinski, Vincent A. Fischetti, Assaf Raz
  • Patent number: 10588972
    Abstract: The present invention relates to compositions and methods for destroying target cells in a patient using photodynamic therapy. In particular, the present invention provides a photosensitizing agent based on a small molecular weight (<50 kDa) protein or peptide or a small molecule that is conjugated to a phthalocyanine dye, such as IRDye® 700DX.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: March 17, 2020
    Assignee: LI-COR, INC.
    Inventor: Joy L. Kovar
  • Patent number: 10588973
    Abstract: The embodiments provide a percutaneous absorption composition for a basic medicament having improved transdermal absorbability. The percutaneous absorption composition comprises a sorbic acid and/or a metal sorbate as a percutaneous absorption promotor. The molar ration of the sorbic acid and/or the metal sorbate to the basic medicament is 0.5-2.5. The composition of the present disclosure may further comprise a basic component.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: March 17, 2020
    Assignee: MEDRx Co., LTD
    Inventors: Yasushi Miwa, Hidetoshi Hamamoto, Naoya Akazawa
  • Patent number: 10588974
    Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: March 17, 2020
    Assignee: RECEPTOR HOLDINGS, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Patent number: 10588975
    Abstract: The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: March 17, 2020
    Assignee: Wyeth LLC
    Inventors: Mahdi B. Fawzi, Tianmin Zhu, Syed M. Shah
  • Patent number: 10588976
    Abstract: Anti-CD40 antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration of the antibody active ingredient for delivery to a patient without high levels of antibody aggregation. The lyophilisate can be reconstituted with an aqueous reconstituent to provide an aqueous composition in which the antibody has a concentration of at least 50 mg/ml. The lyophilisate or aqueous pharmaceutical composition may include one or more of a sugar, a buffering agent, a surfactant, and/or a free amino acid.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: March 17, 2020
    Assignee: Novartis AG
    Inventors: Claudia Mueller, Matthias Willmann
  • Patent number: 10588977
    Abstract: The invention provides a composition containing hyaluronic acid (HA) or a pharmaceutically-acceptable salt thereof preserved with a cationic preservative and related methods. In one embodiment, the pharmaceutically-acceptable salt is sodium hyaluronate. In another embodiment, the cationic preservative includes benzalkonium chloride (BAK).
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: March 17, 2020
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Uday Doshi, Kenneth T. Holeva
  • Patent number: 10588978
    Abstract: Provided in the present invention is a pharmaceutical composition containing an imidazoline derivative. In particular, the pharmaceutical composition provided in the present invention contains (S)-4-(3-(4-(2,3-dihydroxypropoxy)phenyl)-4,4-dimethyl-5-carbonyl-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile and cellulose ether; and the composition has a good stability, dissolution rate and bioavailability.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: March 17, 2020
    Assignee: JIANGSU HENGRUI MEDICINE CO., LTD.
    Inventors: Yun Lu, Xinhua Zhang, Daimei Zhang
  • Patent number: 10588979
    Abstract: The present invention discloses a topical composition comprising terpene blend and cannabidiol (CBD) or a derivative thereof, useful for managing pain, the treatment or prevention of inflammatory skin disorders, and treatment methods thereof. The composition includes 2-pyrrolidone-5-carboxylic acid and a blend of antioxidants to optimize tissue health.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: March 17, 2020
    Inventors: Cody D. Freeze, Allison N. Freeze
  • Patent number: 10588980
    Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: March 17, 2020
    Assignee: Novartis AG
    Inventors: Alexandra Marshall Bruce, Aimee Richardson Usera, Frederic Zecri, Jun Yuan, Changgang Lou, Aaron Kanter
  • Patent number: 10588981
    Abstract: Herein described is a system for the placement of dies on a substrate that uses a rotating turret carried with the die placement system to supply die placement heads necessary for the placement of various dies on a substrate, where multiple dies are to be placed, to a force application rod, thereby allowing for the rapid and efficient placement of a variety of dies on a single substrate.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: March 17, 2020
    Assignee: MRSI Systems LLC
    Inventor: Nicholas Samuel Celia, Jr.
  • Patent number: 10588982
    Abstract: Methods and compositions are described herein for covalently linking an antibody to a molecular payload. Compositions are described herein containing an antibody covalently linked to a molecular payload.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: March 17, 2020
    Assignee: The Regents of the University of California
    Inventors: Diana Lac, Chun Feng, Gaurav Bhardwaj, Siddarth Chandrasekaran, Kit S. Lam
  • Patent number: 10588983
    Abstract: The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: March 17, 2020
    Assignee: Halozyme, Inc.
    Inventors: Louis H. Bookbinder, Anirban Kundu, Gregory I. Frost
  • Patent number: 10588984
    Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: March 17, 2020
    Assignees: Aura Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Elisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
  • Patent number: 10588985
    Abstract: Pharmaceutical compositions, methods of treatment of proliferative diseases and commercial packages are provided according to aspects of the present invention which relate to a first therapeutic agent coupled to a nanoparticle, wherein the first therapeutic agent is SMI #8 or SMI #9 a pharmaceutically acceptable salt, ester, amide, stereoisomer, hydrate, or derivative of either thereof. According to particular aspects, the SMI #8 or SMI #9 is conjugated to gold nanoparticles.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: March 17, 2020
    Assignee: Wayne State University
    Inventors: Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
  • Patent number: 10588986
    Abstract: The present invention relates to biofunctionalized nanoparticles and uses thereof in adoptive cell therapy. In particular, the present invention relates to a nanoparticle comprising an amount of at least one antigen and an amount of at least one antibody having specificity for a B cell receptor wherein the antigen and antibody are attached to the surface of the nanoparticle.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: March 17, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ENS-ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD-LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), HOSPICE CIVILS DE LYON
    Inventors: Antoine Sicard, Olivier Thaunat
  • Patent number: 10588987
    Abstract: The present invention relates to compositions and methods for use in medical diagnosis and patient monitoring. It more particularly relates to a biocompatible gel comprising nanoparticles and/or nanoparticle aggregates, wherein: i) the nanoparticles and/or nanoparticles of said aggregate comprise an inorganic material comprising at least one metal element having an atomic number Z of at least 25, each of said nanoparticles and nanoparticle aggregates being covered with a biocompatible coating; ii) the nanoparticles' and/or nanoparticle aggregates' concentration is of about or less than 0.5% (w/w); and iii) the apparent viscosity at 2 s?1 of the gel comprising the nanoparticles and/or nanoparticle aggregates is between about 0.1 Pa·s and about 1000 Pa·s when measured between 20° C. and 37° C. The composition of the invention typically allows the delineation and visualization of at least 40% of the target biological tissue when said tissue is observed using an X-ray imaging equipment.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: March 17, 2020
    Assignee: NANOBIOTIX
    Inventors: Laurence Poul, Laurent Levy, Celine Berjaud, Matthieu Germain, Agnes Pottier
  • Patent number: 10588988
    Abstract: Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA suitable for in vivo use.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: March 17, 2020
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Carol Walker, David C. Onthank, Joel Lazewatsky, Nhung Tuyet Nguyen
  • Patent number: 10588989
    Abstract: The present invention provides compositions and methods for sanitization or sterilization of, or reduction or elimination of microbes from, PFR material, in particular material for use as an animal bedding. In another aspect, the invention provides sanitized or sterilized material, and especially animal bedding material, prepared using the described compositions and methods.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: March 17, 2020
    Assignee: Green Products Company
    Inventors: Mathew Schryver, Aubrey F. Mendonca
  • Patent number: 10588990
    Abstract: A system handles the sterilization of thin-body, pouch-type, flexible containers (1) and provides for applying sacrificial closures (200) to the pouches. The system loads the provisional closed pouches to be sterilized on a transport device (300) for collective transport, to perform the sterilization of the transport device (300) carrying the provisional closed pouches. The system separates in a sterile chamber, the sacrificial closures (200) from the pouches, performing filling and applying an inviolable cap (100).
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: March 17, 2020
    Assignee: GUALA PACK S.p.A.
    Inventor: Stefano Tamarindo
  • Patent number: 10588991
    Abstract: A disinfectant device including a pouch, the pouch including a first layer of material coupled to a second layer of material and defining a compartment therebetween. At least one dry reactant is retained within the compartment, the at least one dry reactant producing chlorine dioxide gas when exposed to water. A wick is at least partially disposed within the compartment. At least one from the group consisting of the first layer of material and the second layer of material define an array of ports along a periphery of the pouch and an array of fluid conduits, the array of fluid conduits being proximal to the array of ports, offset from the array of ports, in fluid communication with the wick, the compartment, and the array of ports.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: March 17, 2020
    Assignee: Odorstar Technology, LLC
    Inventor: Peter Dornau
  • Patent number: 10588992
    Abstract: An aerosol device having a bowl with a bottom defining a drain, and a side wall extending from the bottom to a rim. A nozzle is disposed within the bowl. The nozzle defines a chamber and an outlet orifice directed toward the side wall of the bowl. The aerosol device includes a liquid container fluidly coupled to the nozzle via a first conduit having an outlet tip disposed within the chamber of the nozzle and a second conduit connecting a source of pressurized gas to the chamber of the nozzle. The outlet tip is in the form of a tube defining elongated slots communicating from inside the tube to outside the tube, the slots each having a width defined between two parallel tube surfaces. The aerosol device generates submicron liquid droplets, and is suitable for disinfecting porous articles in an enclosed volume.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: March 17, 2020
    Assignee: Watertech Holdings LLC
    Inventors: Eric August Frische, Christopher Benedict Spaulding, Thomas Kurt Klemann
  • Patent number: 10588993
    Abstract: A luminaire for disinfecting a target surface includes a disinfecting light source, a non-disinfecting light source, a beam angle adjustor, a motion sensor, and a distance sensor. The radiance of the disinfecting light is calculated based on detected distance to a target surface and beam angle, and may be selected to achieve a predetermined irradiance of the target surface. If no motion is detected by the motion sensor then the disinfecting light source is set to ON and the non-disinfecting light source is set to OFF. If motion is detected and a beam intercept is not detected by the distance sensor then the disinfecting light source is set to DIM and the non-disinfecting light source is set to ON. If motion is detected and a beam intercept is detected then the disinfecting light source is set to OFF and the non-disinfecting light source is set to ON.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: March 17, 2020
    Assignee: OSRAM SYLVANIA Inc.
    Inventor: Michael A. Quilici
  • Patent number: 10588994
    Abstract: Provided is an automated manufacturing cell including: a work booth provided with a work space; a robot arranged in the work booth; a container booth which is connected, in a manner allowing insulation, to each of the work booth and an external space, and is configured to store a work tool and a work subject; and a holder fixation tool which is arranged in the work space, and is configured to detachably fix a holder configured to hold the work tool.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: March 17, 2020
    Assignees: Kabushiki Kaisha Yaskawa Denki, Tanabe Engineering Corporation
    Inventors: Yoshinori Kawamura, Sakae Yamaguchi, Takashi Obunai, Takuetsu Oishi
  • Patent number: 10588995
    Abstract: Sterilization tray fasteners are disclosed herein. The disclosed sterilization tray fasteners may be formed to join sterilization tray bases stacked directly on top of one another together. In some embodiments, sterilization tray bases may be formed to have slots or apertures to accommodate features of the disclosed fasteners. For example, in some embodiments, the disclosed sterilization tray fasteners include an elongate body and two curved arms that can extend into apertures of the sterilization tray bases. In many embodiments, the disclosed fasteners can be attached to and detached from sterilization tray bases without tools.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: March 17, 2020
    Assignee: Specialty Surgical Instrumentation, Inc.
    Inventors: Sejal Rao, Jose Fernandez, Drew Jones, Tom Sullivan
  • Patent number: 10588996
    Abstract: A vent balloon, including an inflatable body operatively attached to a molded plastic base on a proximal side, wherein the inflatable body is inflated by a mechanism of an air vent or a fan operatively attached to the molded plastic base, and including a scent mechanism operatively attached to the molded plastic base for dispersing scent in a room that relates to a design on the inflatable body. A method of using a vent balloon by flowing air through an inflatable body of a vent balloon through a molded plastic base, wherein the air comes from a source of an air vent or a fan operatively attached to the molded plastic base, inflating the inflatable body, and flowing air over at least one scent mechanism operatively attached to the molded plastic base that relates to a design on the inflatable body and releasing scent into the air.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: March 17, 2020
    Inventor: William Paul Warkentin
  • Patent number: 10588997
    Abstract: A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: March 17, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Jonathan Pokorski
  • Patent number: 10588998
    Abstract: Adhesive compositions and patches, and associated systems, kits, and methods, are generally described. Certain of the adhesive compositions and patches can be used to treat tissues (e.g., in hemostatic or other tissue treatment applications), according to certain embodiments.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: March 17, 2020
    Assignee: Xcede Technologies, Inc.
    Inventors: Daniel Grant Ericson, Kyle Robert Brandy
  • Patent number: 10588999
    Abstract: Techniques for creating a mesoporous surface for enhanced bone integration are provided. An example of a method for generating a mesoporous surface on a substrate includes depositing a layer of titanium on an area of the substrate to generate a nano-textured surface, and anodizing the layer of titanium on the area of the substrate to generate the mesoporous surface. The method may also include incorporating pharmaceutical, biological, or molecular additives into the mesoporous surface intended to further enhance performance of the substrate via enhanced osseoconduction, osseoinduction, or antimicrobial/anti-infective properties.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: March 17, 2020
    Assignee: N2 BIOMEDICAL LLC
    Inventors: Nader Montazemezam Kalkhoran, Eric Tobin, Jason Burns
  • Patent number: 10589000
    Abstract: A bone substitute material is disclosed consisting of a zirconium dioxide ceramic having preferably an open porosity. The bone substitute material can be used in particle form or in block form.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: March 17, 2020
    Inventors: Michael Gahlert, Stefan Gahlert
  • Patent number: 10589001
    Abstract: A pharmaceutical formulation for use in a spinal fusion method, comprising a composition for forming a matrix, a kit comprising the composition, a pharmaceutical product obtainable from the pharmaceutical formulation, and an interbody spinal fusion cage containing the pharmaceutical formulation or the pharmaceutical product are described herein. The composition comprises at least a first matrix material precursor component and a second matrix material precursor component that are able to crosslink to form the matrix under appropriate conditions, a bioactive factor that is biologically active for stimulating bone formation between two vertebrae and for effecting or supporting spinal fusion. The bioactive factor is PTH, optionally a PTH fusion peptide. The bioactive factor is releasably incorporated in the matrix upon crosslinking of the matrix material precursor components.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: March 17, 2020
    Assignee: Kuros Biosurgery AG
    Inventors: Jason Schense, Silke Mark, Monica Alvisi, Maria Angeles Martinez Vargas
  • Patent number: 10589002
    Abstract: Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: March 17, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Hongbin Jiang, William R. Wagner, Tomo Yoshizumi, Yang Zhu
  • Patent number: 10589003
    Abstract: Disclosed are methods for coating or impregnating a surface with an antimicrobial agent that involve contacting the surface with a composition that includes an antimicrobial agent and a solvent, and curing the surface by applying heat. Also disclosed are methods for reducing the risk of development or progression of an infection in a subject in need of a medical device, that involve coating or impregnating a surface of the medical device with an antimicrobial agent and then curing the surface by applying heat, wherein the risk of development or progression of an infection is reduced.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: March 17, 2020
    Assignee: The Board of Regents of the University of Texas System
    Inventor: Issam Raad
  • Patent number: 10589004
    Abstract: Biomaterials and methods and uses for repair or augmentation of tissues are provided. In particular, the invention provides a multi-layered, naturally occurring multi-axial oriented biomaterial comprising predominately type I collagen fibers. The invention further provides methods and uses for repair or augmentation of tissues using biomaterials of the invention.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: March 17, 2020
    Inventors: Barry K. Bartee, Richard A. Rosen
  • Patent number: 10589005
    Abstract: A bioerodible endoprosthesis includes a bioerodible body including an alloy comprising at least 85 weight percent magnesium and at least one high-melting-temperature element having a melting temperature of greater than 700° C. The alloy has a microstructure including equiaxed magnesium-rich phase grains and optionally high-melting-temperature intermetallic phases. The equiaxed magnesium-rich phase grains have an average grain diameter of less than or equal to 10 microns. High-melting-temperature intermetallic phases, if present, can have an average longest dimension of 3 microns or less.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: March 17, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Jacob Drew Edick, Jonathan S. Stinson
  • Patent number: 10589006
    Abstract: Provided are a microneedle with excellent performance and a method for manufacturing the microneedle. A microneedle array in which a polyglycolic acid is used as a material, crystallinity of the polyglycolic acid is 21% or more and axial contraction rate of tips is 99% or more, and a manufacturing method in which a polyglycolic acid are injection-molded at a cylinder temperature of 230-280° C., a metal mold temperature of 60-130° C., and an injection pressure of 1000-1500 KPa so as to manufacture a microneedle array in which crystallinity of the polyglycolic acid is 21% or more and an axial contraction rate of tips is 99% or more.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: March 17, 2020
    Assignee: COSMED PHARMACEUTICAL CO., LTD.
    Inventors: Ying-shu Quan, Ying-zhe Li, Mio Saito, Shouta Kitaoka, Fumio Kamiyama
  • Patent number: 10589007
    Abstract: A moisture trap for removing liquid from a fluid drawn from a tissue site treated with reduced pressure and systems and methods for using the same are described. The moisture trap may include a barrier adapted to be fluidly coupled to and define an indirect fluid path between a fluid reservoir and a reduced-pressure source. The barrier may have a hydrophilic surface. The moisture trap also may include a sump adapted to receive condensation from the barrier.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: March 17, 2020
    Assignee: KCI Licensing, Inc.
    Inventors: Richard Daniel John Coulthard, Christopher Brian Locke
  • Patent number: 10589008
    Abstract: A tubing set for use in a blood processing apparatus comprises a measurement device (8) having at least one chamber element (80, 81) for measuring a haematocrit value of a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L) and encompassing a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The tubing set furthermore comprises an inlet-side tube section (21, 31) connected to the inlet port (800, 810) and an outlet-side tube section (22, 30) connected to the outlet port (801, 811).
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: March 17, 2020
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Frank Schmidt, Artur Meisberger, Melanie Fahrendorff, Ilka Sternheimer, Lars Michel
  • Patent number: 10589009
    Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 17, 2020
    Assignee: ExploraMed NC7, Inc.
    Inventors: Joshua Makower, John Y Chang, Michele Torosis, Michael Landry, Earl Bright, II, Alan W Cannon
  • Patent number: 10589010
    Abstract: An artificial heart for use in a human recipient includes a housing within which a quartet of turbine pump segments are operative. The quartet of turbine pump segments is configured to provide a pair of redundant input and output turbine pump segment pairs each input and output pair being coupled by a curved passage providing a redundancy which, in turn, enhances the safety factor provided by the artificial heart. A controller is powered by a rechargeable battery and is operative to apply appropriate drive signals to the motor drives of the turbine pump segments. The battery may be implanted along with the controller to avoid the need for any external connections to the artificial heart. An inductively coupled battery charger for use outside the recipient's body is positioned proximate the battery charger to provide inductively coupled charging for use in driving the artificial heart.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: March 17, 2020
    Inventors: Peter DeSilva, Steve Smith
  • Patent number: 10589011
    Abstract: A ventricular assist device includes a pump configured to pump blood of a patient. A motor is configured to operate the pump. First, second, and third conductors are coupled to the motor and are configured to supply electric current from a power supply to the motor in first, second, and third phases, respectively. A controller is configured to operate the motor using a Field Oriented Control (FOC) method, and if one from the group consisting of first, second and third conductors becomes unable to supply electric current to the motor, the controller continues to operate the motor using the FOC method using the phases of the two conductors that are able to supply electric current to the motor.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: March 17, 2020
    Assignee: HeartWare, Inc.
    Inventors: Fernando Casas, Carlos Reyes, Justin Wolman
  • Patent number: 10589012
    Abstract: The invention relates to a blood pump for the invasive application within a body of a patient comprising a rotor (43, 27) which is drivable about an axis of rotation and is radially compressible or expandable and which has a hub (18, 28) and at least one impeller blade (14, 15, 16, 17, 29, 30) fastened thereto, as well as comprising a housing (19, 19?) which is compressible or expandable in the radial direction by an axial stretching or axial compression. The object of making both the rotor and the housing expandable and compressible in as simple a manner as possible is achieved in accordance with the invention in that a control body (21) is provided which passes through the hub (18) in the longitudinal direction, which is freely axially displaceable relative to the hub and which is coupled to the housing on the distal side of the rotor such that it exerts pulling and/or compression forces on the housing by a movement in the longitudinal direction with respect to the housing.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: March 17, 2020
    Assignee: ECP ENTWICKLUNGSGESELLSCHAFT MBH
    Inventors: Thomas Toellner, Mario Scheckel