Abstract: Methods of measuring the activity of Factor D, the key driver in the activation of the alternative complement pathway, methods of determining the potency of Factor D inhibitors, and methods of screening for Factor D inhibitors are provided.

Abstract: A method assaying the levels of expression Apolipoprotein AI, Apolipoprotein AII, E-Cadherin, and Galectin-3 in a biological sample from a person having or suspected of having colorectal cancer. The sample is remote from any tumor.

Abstract: [Problem] To provide a method for acquisition of data able to serve as an index for determining the likelihood that an ovarian endometriosis cyst is cancerous. Solution This data acquisition method for determining the likelihood that an ovarian endometriosis cyst is cancerous includes an iron concentration measurement step for measuring the iron concentration in the cystic fluid of the ovarian endometriosis cyst. This diagnostic device for diagnosing the likelihood that an ovarian endometriosis cyst is cancerous is provided, at a minimum, with an iron concentration measurement unit for measuring the iron concentration in the cystic fluid of the ovarian endometriosis cyst.

Abstract: Highly specific and novel methods for analyzing glycans and proteoglycans are provided. The present invention provides glycan-reactive isobaric Aldehyde-Reactive Tags (iARTs) and the quantification of iARTs-labeled glycans by tandem mass spectrometry. The iARTs have an amine as an active group to react with aldehyde at the reducing end of glycans through reductive amination and demonstrated complete labeling. Due to the isobaric nature of the iARTs, differentially labeled glycans do not differ in mass, and quantitative information is provided by the isotope-encoded reporter ions generated from MS/MS or MS3 spectra. Quantitative information is thus derived from signal of the reporter ions on same precursor. Uses of the information generated by the inventive methods for diagnosis and treatment are also disclosed.

Abstract: There are provided dicysteine peptide tags for use with dimaleimide fluorescent labelling agents for the labelling and detection of specific protein targets. Peptide tags comprising the amino acid sequence set forth in SEQ ID NO: 2 are described.

Abstract: A method for detecting an interaction between one or more protein bait and one or more candidate prey in a eukaryotic cell, comprising the steps of: a) providing an eukaryotic cell expressing (i) one or more protein bait, and (ii) one or more candidate prey, wherein said protein bait comprises a bait moiety and a polymerized-tubulin binding moiety. b) determining the occurence of an interaction between said one or more protein bait and said one or more candidate prey in the eukaryotic cell, wherein said protein bait is bound to polymerized tubulin in the eukaryotic cell, thereby localizing said one or more candidate prey along said polymerized tubulin, thereby detecting said interaction.

Abstract: Disclosed is a angiogenesis inhibition determining method using MALDI mass spectrometry, and more particularly, relate to a method for detecting whether small molecules are bound with a target protein and for measuring a binding distribution between the small molecules and the target protein by comparing a result of MALDI mass spectrometry with a result of immunofluorescence of the small molecules, which are used as drugs, for the target protein, and for determining as angiogenesis is inhibited in a portion overlapping with a portion where the drug small molecules are present after the MALDI mass spectrometry in the cell or in the biosample including organelles and a portion where the target protein is present after immunofluorescence, as well as for detecting presence or absence and a distribution state of small molecules used as drugs in a sample by using MALDI mass spectrometry.

Abstract: Devices and methods for characterization of samples are provided. Samples may comprise one or more analytes. Some methods described herein include performing enrichment steps on a device. Some methods described herein include performing mobilization of analytes. Analytes may then be further processed and characterized.

Abstract: Chronic inflammation is an increasing medical problem area of high socioeconomic significance. The invention relates to a method and a kit for diagnosing a molecular phenotype of a patient suffering from an illness accompanied by chronic inflammation, and to a medicament for treating such a patient. To that end, the gene expression of GATA-3 and/or Tbet in a biological isolate of the patient is measured and used for association with a molecular phenotype of the illness.

Abstract: Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.

Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.

Abstract: Methods of measuring the amount of singly- or multiply-phosphorylated p217+ tau protein in a sample are provided. Methods of detecting or diagnosing tauopathies, methods of determining the effectiveness of a treatment of a tauopathy, and methods of determining whether a subject is suitable for anti-p217+ tau antibody therapy are also provided. Also described are antibodies for use in the methods and kits comprising the antibodies.

Abstract: Compounds are of the formula (Ia), (Ib), (Ic), or are stereoisomers thereof, wherein: R1 is hydrogen, (C1-C20)alkyl; (C3-C20)alkenyl; (C3 C20)alkynyl; (C1-C6)alkyl-O—; (C3-C20)cycloalkyl; (C1 C20)haloalkyl; (C6-C20)aryl optionally substituted; (C6-C20)heteroaryl optionally substituted; R2 and R2? are hydrogen; (C1-C20)alkyl; (C1-C6)alkyl-O—; (C1-C6)haloalkyl; halogen; cyano; and nitro; Z1 to Z4 are diradicals of formula (III) wherein A1 and A2 are O— or NR3-, wherein R3 is selected from the group consisting of hydrogen and (C1-C20)alkyl; and G is (C1-C6)alkyl; —P(?S)R5-; —P(?O)R4; —P(?O)(OR4)-; —P(?O)(NR6R7)-; —S(?O)2-; S(?O)—; or —C(?O)—; and Y1 to Y4 are (C1-C8)alkyl; (C3-C7)cycloalkyl; (C6-C20)aryl optionally substituted; or (C6-C20)heteroaryl optionally substituted; and FG1 and FG2 are H, OH, or NHR8.

Abstract: The invention relates to an in vitro diagnosis device (10) for the detection of at least one reaction between an erythrocytic phenotype antigen and an antibody specifically directed against said antigen in a sample of blood or one of the components thereof. The device is characterized in that it comprises: a substrate (12); and a hydrophobic porous membrane (14) having a thickness of between 0.5 mm and 1.5 mm and a pore diameter of between 2 and 30 ?m, said membrane comprising at least one hydrophilic reaction zone (16) intended to receive the sample. The invention also relates to the uses of said device in immunohematology.

Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.

Abstract: Disclosed is a method and apparatus for determining a concentration of a glycopeptide antibiotic containing a phenol moiety such as Vancomycin in a complex sample matrix by extracting the glycopeptide antibiotic from a metered portion of the complex sample matrix by exposing said metered portion to an extraction material having an affinity with the glycopeptide antibiotic; and exposing the extraction material to a metered portion of an eluent for releasing the glycopeptide antibiotic from the extraction material; and by determining a concentration of the glycopeptide antibiotic by adding a Gibbs reagent (2,6 dichloroquinone-4-chloroimide) to the metered portion of the complex sample matrix or the eluent; activating the Gibbs reagent and, after the reaction between the activated Gibbs reagent and the antibiotic has stabilized; detecting the reaction product of the activated Gibbs reagent and the antibiotic in said eluent; and determining the concentration of the antibiotic in the complex sample matrix from the

Abstract: An immunoassay method for detecting and determining adamantane substituted indazole and indole synthetic cannabinoids is described. Also described are components for use in implementing the method, namely, antibodies, detection agents, solid state devices and kits as well as immunogens used to raise the antibodies.

Abstract: Provided is an automatic analyzer capable of replacing an insertion mechanism while suppressing occurrence of dispensing abnormality and analysis result abnormality accompanying deterioration of the insertion mechanism. Included are an insertion mechanism that is inserted into a closed container through a lid of the container; a storage unit that stores an insertion history count corresponding to a cumulative load of the insertion mechanism caused by inserting the insertion mechanism into a plurality of the containers, and an allowable insertion history count which is an allowable value of the insertion history count; and a control unit that compares the insertion history count with the allowable insertion history count and performs control to make a notification to an operator in a case where the insertion history count reaches the allowable insertion history count.

Abstract: The disclosure concerns a method for operating an automated analyzer, including transporting a liquid containing a plurality of particles into a chamber, such as a reactor chamber and/or measuring cell chamber of the analyzer, introducing a gas or gas mixture, for example, air into the chamber, such as through the liquid present in the chamber so that the particles in the liquid are stirred up, and subsequently draining at least part of the liquid from the chamber through a fluid line ending in the chamber and an open valve arranged in the fluid line.

Abstract: A sample analyzer includes: a reagent container holder including a reagent container holder body configured to hold a reagent container, and a tilt changing part configured to change a tilt of the reagent container holder body; a reagent dispenser configured to aspirate a reagent contained in the reagent container held in the reagent container holder body; a detector configured to detect a signal for analysis from a measurement specimen containing a sample and the reagent dispensed by the reagent dispenser; and a controller that analyzes the sample on the basis of the signal detected by the detector.

Abstract: The invention relates to an automated method for the optical analysis of structures, in particular for the analysis and determination of biological cellular structures, and to an apparatus for this purpose, wherein an electro-optical unit generates an electronic image of two- and three-dimensional structures present in the sample, a storage medium stores the image, a computer-controlled displacement device establishes an optimized image sharpness of the image by changing the distance between sample and the optical unit, wherein the displacement device is controlled by contrast analysis and color value detection, and a computer unit compares the images generated by the electro-optical unit of two- and/or three-dimensional structures with the known structures stored in a database, and the structures registered by the optical unit are assigned by means of an algorithm to characteristic grids, structures or patterns.

Abstract: A cassette may include a substrate, a die coupled to the substrate, a reservoir defined in a first side of the substrate exposing a proximal side of the die to an external atmosphere, and an overflow reservoir defined in the first side of the substrate and surrounding at least a portion of a perimeter of the reservoir.

Abstract: A system utilizes a flow cell for holding an analyte of interest for examination, such as a genetic material to be imaged for sequencing. Liquids, such as reagents and washing fluids are introduced into the flow cell during operations. A degasser removes gasses from at least some of the liquids before introduction into the flow cell. The liquids may be resident in the flow cell during detection operations, such as imaging. At least one fluid may be moved bidirectionally into and from the flow cell, such as for reuse. Another fluid may be moved unidirectionally through the flow cell to remove bubbles that may be present in the system.

Abstract: The present disclosure relates to an inertia measurement module for an unmanned aircraft, which comprises a housing assembly, a sensing assembly and a vibration damper. The vibration damper comprises a first vibration-attenuation cushion; and the sensing assembly comprises a first circuit board, a second circuit board and a flexible signal line for connecting the first circuit board and the second circuit board. An inertia sensor is fixed on the second circuit board, and the first circuit board is fixed on the housing assembly. The inertia measurement module further comprises a weight block, and the second circuit board, the weight block, the first vibration-attenuation cushion and the first circuit board are bonded together. The present disclosure greatly reduces the influence of the operational vibration frequency of the unmanned aircraft on the inertia sensor and improves the measurement stability of the inertia sensor.

Abstract: The accelerometric sensor has a suspended region, mobile with respect to a supporting structure, and a sensing assembly coupled to the suspended region and configured to detect a movement of the suspended region with respect to the supporting structure. The suspended region has a geometry variable between at least two configurations associated with respective centroids, different from each other. The suspended region is formed by a first region rotatably anchored to the supporting structure and by a second region coupled to the first region through elastic connection elements configured to allow a relative movement of the second region with respect to the first region. A driving assembly is coupled to the second region so as to control the relative movement of the latter with respect to the first region.

Abstract: The purpose of the present invention is to provide a rotation speed detection device which achieves improved detection accuracy regardless of a compressor and the operating state of the compressor, and enables the prevention of the breakage of a detection unit. A rotation speed detection device for a compressor, wherein a detection unit for detecting full blades and splitter blades that are blades approaching a compressor casing of the compressor in response to a change in the inductance of a magnetic field is provided. The detection unit is provided in an overlap region in which the full blades and the splitter blades that are all blades can be detected and the exposure pressure is in the range of a gauge pressure of one atmosphere or less.

Abstract: A MEMS accelerometric sensor includes a bearing structure and a suspended region that is made of semiconductor material, mobile with respect to the bearing structure. At least one modulation electrode is fixed to the bearing structure and is biased with an electrical modulation signal including at least one periodic component having a first frequency. At least one variable capacitor is formed by the suspended region and by the modulation electrode in such a way that the suspended region is subjected to an electrostatic force that depends upon the electrical modulation signal. A sensing assembly generates, when the accelerometric sensor is subjected to an acceleration, an electrical sensing signal indicating the position of the suspended region with respect to the bearing structure and includes a frequency-modulated component that is a function of the acceleration and of the first frequency.

Abstract: A method for forming an MEMS inertial sensor is provided, comprising: providing a first substrate having a first surface and a second surface, wherein providing the first substrate comprises providing a first base substrate and forming at least one conductive layer; providing a second substrate having a third surface and a fourth surface; bonding the first surface of the first substrate and the third surface of the second substrate together to form a first bonding interface; thinning the first base substrate from the second surface of the first substrate to remove part of the first base substrate; and forming a movable element of the MEMS inertial sensor, wherein the at least one conductive layer comprises a shielding layer, and the shielding layer is located between the first base substrate and the first bonding interface.

Abstract: A tunnel current control apparatus includes a terahertz wave generation element configured to generate and output a terahertz wave pulse, a CEP adjustment unit configured to adjust a CEP of the terahertz wave pulse, and an off-axis parabolic mirror serving as a focusing element configured to focus the terahertz wave pulse in a gap between a first conductive object and a second conductive object. The CEP adjustment unit can arbitrarily adjust the CEP of the terahertz wave pulse.

Abstract: The disclosure describes a novel method and apparatus for improving silicon interposers to include test circuitry for testing stacked die mounted on the interposer. The improvement allows for the stacked die to be selectively tested by an external tester or by the test circuitry included in the interposer.

Abstract: Coaxial microwave transistor test fixtures provide lowest insertion loss possible and include, as part of the input and output sections, transformer networks in form of single stage ?/4 segments bringing (pre-matching) the system 50? load closer to the conjugate internal impedance of power transistors. The transforming networks are flat, cylindrical or have oval or elliptical cross sections and have adjustable length, thus operating optimally for transistors with varying optimum frequency and internal impedance and/or capacitive or inductive impedance part. The change in length is done without affecting the overall fixture geometry and structure. The fixtures can be calibrated using standard TRL method.

Abstract: Measurement apparatuses and methods are described. A measurement input is coupled with a first terminal of a capacitance via a first switch, and a reference voltage is coupled with the first terminal of the capacitance via a second switch. A measurement circuit is coupled to a second terminal of said capacitance.

Abstract: A coil arrangement has an electrical coil and an armature movable between a first and second end positions, an electronic switch switchable between at least two switch states, a control and monitoring circuit for producing a switching signal actuating the electronic switch and an operating circuit for providing an operating voltage and an electrical current measurement signal representing an electrical current flowing as a function of time in a coil electrical current circuit formed with the coil. The control and monitoring circuit is adapted to detect whether an inductance of the coil has a dependence on the switching signal as a function of time. The electromechanical has a first switch contact movable between first and second switch positions, a second switch contact and a coil arrangement of the invention, while the measurement transmitter has also a measuring circuit for receiving at least one transducer signal.

Abstract: A current measuring device is protected against electrical surges in the event of the device being open circuit. The device includes a first current transformer, a first connection terminal having connected thereto a first terminal of the first current transformer, a second connection terminal having connected thereto a second terminal of the first current transformer, a protective resistance having a first terminal connected to the second connection terminal, and a load resistance connected between the first and second connection terminals across the terminals of which a voltage is measured from which the current flowing in a circuit passing through the first current transformer is determined. The device also includes a second current transformer connected to the terminals of the protective resistance, and current branch connection structure connected between the first connection terminal and a second terminal of the protective resistance.

Abstract: Systems and methods provide a non-contact current measurement system which operates to measure alternating current flowing through an insulated wire without requiring galvanic contact with the insulated wire. The measurement system may include a magnetic field sensor that is selectively positionable proximate an insulated wire under test. In operation the magnetic field sensor detects a magnetic field generated by the current flowing in the insulated wire. Using an adjustable clamp assembly, the measurement system provides control over the mechanical positioning of the insulated wire relative to the magnetic field sensor to ensure consistent measurements. The non-contact current measurement system may determine information relating to the physical dimensions (e.g., diameter) of the insulated wire.

Abstract: In circuitry for measuring a voltage at a node, a capacitive divider is coupled to the node, wherein the capacitive divider provides a first output. A resistive divider is coupled to the node, wherein the resistive divider provides a second output.

Abstract: An electrical fault detector is shown for installation in electrical network (101) of the type comprising a first voltage source (104) and a second voltage source (107), each of which have a respective positive rail (105,108) connected by a positive concentrator (110) and a respective negative rail (106,109) connected by a negative concentrator (111). The detector comprises an inductor (112) for location in one of: the positive concentrator between the connections of the positive rails thereto, and the negative concentrator between the connections of the negative rails to thereto. The detector also comprises a fault identification device (113) configured to monitor the voltage across the inductor, and generate a fault signal in response to the voltage across the inductor exceeding a threshold.

Abstract: Some demonstrative embodiments include an apparatus including a low-voltage detector to detect whether a voltage difference between a first voltage of a first voltage domain and a second voltage of the first voltage domain is lower than a predefined voltage.

Abstract: A wind turbine generator fault detection method is described. The method includes acquiring current data from a wind turbine generator during operation, determining frequency demodulated signals and amplitude demodulated signals by frequency demodulating and amplitude demodulating the current data, resampling the frequency and amplitude demodulated signals corresponding to the current data, monitoring a frequency spectra of the resampled frequency and amplitude demodulated signals corresponding to the current data to identify one or more excitations in the frequency spectra. In response to identifying one or more excitations in the frequency spectra at one or more of the variable fault characteristic frequencies, the method includes generating and transmitting an alert that indicates that a wind turbine generator fault is detected.

Abstract: An alternating current (AC) power flow analysis in an electrical power network. Based on information relating to buses and transmission lines connecting the buses in the electrical power network, a convex approximation of AC power flows in the electrical power network is determined. The convex approximation of the AC power flows comprises convex approximation of nonlinear cosine terms associated with active power components and reactive power components of the AC power flows. A convex objective function associated with the electrical power network is optimised using the convex approximation of the AC power flows.

Abstract: Disclosed embodiments relate to a power monitoring system that may include an external power supply source, an energy storage system and a distribution board. In some embodiments, the power monitoring system includes the external power supply source, the distribution board, the energy storage system, a first power metering device, a second power metering device, a third power metering device and a server.

Abstract: A measurement apparatus (1) comprising a high frequency measurement unit (2) adapted to measure high frequency parameters (HFP) of a device under test (DUT) connected to ports of said measurement apparatus (1) and a multimeter unit (3) adapted to measure DC characteristics parameters (DCP) of said device under test (DUT) connected via control signal lines (CL) to a control bus interface (6) of said measurement apparatus (1).

Abstract: A capacitive sensor is disclosed. The capacitive sensor includes a substrate, a first electrode and a second electrode formed on the substrate, an insulation layer formed on the substrate on which the first electrode and the second electrode are formed, and a sensing layer that is formed on the insulation layer and includes graphene.

Abstract: A measuring device comprising a plurality of analog signal adjusters, and an antenna array, comprising a plurality of antennas is provided. Each of the plurality of antennas is connected to exactly one of the plurality of analog signal adjusters. The analog signal adjusters are adapted to alter the phase and/or amplitude of signals sent and/or received by the plurality of antennas, generating an antenna characteristic of the antenna array comprising at least a first beamforming beam or a first plane wave and a second beamforming beam or a second plane wave.

Abstract: Various approaches can be used to interrogate a surface such as a surface of a layered semiconductor structure on a semiconductor wafer. Certain approaches employ Second Harmonic Generation and in some cases may utilize pump and probe radiation. Other approaches involve determining current flow from a sample illuminated with radiation. Decay constants can be measured to provide information regarding the sample. Additionally, electric and/or magnetic field biases can be applied to the sample to provide additional information.

Abstract: Disclosed herein are embodiments of systems, methods, and products to automatically and intelligently generate a test bench to test an electrostatic discharge (ESD) protection circuit in an integrated circuit (IC) design. A computer may receive netlist of the IC design forming a device under test (DUT). From the DUT, the computer may extract and/or calculate one or more parameters. Based on the one or more parameters, the computer may generate a test bench comprising a resistance inductance capacitance (RLC) circuit to provide ESD stimulus to the DUT. The ESD stimulus and therefore the test bench may be based on a human body model (HBD) or a charged device model (CDM). In case of the CDM, the computer may allow a circuit designer to select or deselect package parameters for testing the ESD protection circuit.

Abstract: A method of iteratively screening a sample of electrolytic capacitors having a predetermined rated voltage is provided. The method can include measuring a first leakage current of a first set of capacitors, calculating a first mean leakage current therefrom, and removing capacitors from the first set having a first leakage current equal to or above a first predetermined value, thereby forming a second set of capacitors. The second set can be subjected to a burn in heat treatment where a test voltage can be applied, then a second leakage current of the second set of capacitors can be measured and a second mean leakage current can be calculated. Capacitors having a second leakage current equal to or above a second predetermined value can be removed from the second set, forming a third set of capacitors. Because of such iterative screening, the capacitors in the third set have low failure rates.

Abstract: A system for use in locating and testing a cable having a first end connected to a first connector and a second end connected to a second connector where the second connector is one of a plurality of connectors within a patch panel. The system includes a first device having a first cable certification and test circuitry which is couplable to the first connector and a second device having a second cable certification and test circuitry which is couplable to the second connector. One of the first device and the second device further includes circuitry for generating a tone signal that is to be applied to the cable and the other one of the first device and the second device further includes a probe for receiving the tone signal and for generating an output indicative of a strength of the received tone signal.

Abstract: A wiring safety evaluation system that makes it possible to easily determine whether a plurality of electrical wires secured in redundancy belong to the same harness to evaluate wiring safety is provided. The wiring safety evaluation system according to the present invention includes a processing section that identifies, after an event ID is specified, whether a gate type of a parent ID corresponding to the event ID is an OR gate or an AND gate, and when the gate type is the OR gate, repeats a process procedure of identifying whether a gate type of a parent ID that is a parent in next generation of the parent ID is an OR gate or an AND gate to determine whether the specified event causes a top event.

Abstract: Coplanar waveguide microwave transistor test fixtures include integrated wideband signal sensors/couplers and allow the detection of the main signal and its harmonic components, generated by a transistor in high power operation mode, by using a phase-calibrated network or signal analyzer and thus the reproduction of real time signal waveforms.