Patents Issued in March 19, 2020
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Publication number: 20200085700Abstract: Formulations suitable for use with fibrous substrates are provided. The formulations provide increased wet strength, high dispersibility, and shape retention of premoistened fibrous substrates. Such formulations comprise at least one dielectric-adjusting solvent, and optionally water, coupling agents, salts, personal care components, hard surface cleaning components, or combinations thereof.Type: ApplicationFiled: September 16, 2019Publication date: March 19, 2020Inventors: Brian Patrick Argo, Abdus Salam, Jennifer L. Faucett, Stephanie Petrina Boyce, Kevin Matthew Holtman, Daniel Peter Gardner, Arinne Nicole Lyman
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Publication number: 20200085701Abstract: The present invention relates to a cosmetic composition in the form of an oil-in-water emulsion, comprising: ?water; ?at least 10% by weight, relative to the weight of the composition, of at least one silicone resin; ?at least one non-volatile silicone oil, not comprising any nitrogen atoms, or any —Si—H groups, or any (poly)oxyalkylene groups, the oxyalkylene unit being C2-C3, or any (poly)glycerol groups; ?at least one nonionic hydrocarbon-based surfactant with an HLB (hydrophilic/lipophilic balance) of greater than or equal to 8 ?optionally at least one first non-volatile hydrocarbon-based oil in a content of less than 15%) by weight, relative to the weight of the composition; said non-volatile hydrocarbon-based oil(s) being chosen from: —C10-C26 alcohols, preferably monoalcohols; —optionally hydroxylated monoesters, diesters or triesters of a C2-C8 monocarboxylic or polycarboxylic acid and of a C2-C8 alcohol, which are optionally hydroxylated; —esters of a C2-C8 polyol and of one or more C2-C8 carboxylicType: ApplicationFiled: December 21, 2017Publication date: March 19, 2020Applicant: L'OREALInventors: Roshanak DEBEAUD, Sandrine FERNANDES, Roberto CAVAZZUTI
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Publication number: 20200085702Abstract: The invention relates to a cosmetic composition in the form of an oil-in-water emulsion comprising: (i) at least one lipophilic surfactant with HLB less than or equal to 9, and (ii) at least one specific anionic surfactant comprising at least one sulfate and/or sulfonate function; said composition comprising from 0% to 8% by weight of additional surfactant(s) relative to the total weight of the composition. It also relates to the associated cosmetic process.Type: ApplicationFiled: December 8, 2017Publication date: March 19, 2020Applicant: L'OREALInventors: Geraldine LEREBOUR, Charlotte LEMAIRE, Franck CLEMENT
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Publication number: 20200085703Abstract: Hair treatment products are provided in the form of two-phase systems with two separate, visually discernible continuous phases with a common vertical phase boundary, containing one water phase (I) and one oil phase (II), wherein the oil phase (II) contains at least about 10% by weight of at least one linear C9-C15 alkane a) relative to the total weight thereof, and wherein the water phase (I) contains at least about 75% by weight water relative to the total weight thereof. The hair treatment products are particularly suitable for improving the feel, particularly of dry hair the styling properties of hair the smoothness and softness of hair (anti-frizz).Type: ApplicationFiled: August 28, 2019Publication date: March 19, 2020Applicant: Henkel AG & Co. KGaAInventors: Sylvia Kerl, Tina Ahnfeldt
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Publication number: 20200085704Abstract: The present invention relates to a process for manufacturing a device for applying a cosmetic product by transfer onto human keratin materials, comprising the step consisting in printing, using at least one digital printer, onto a surface a cosmetic ink, the ink being in the form of an oil-in-water or water-in-oil emulsion comprising an emulsifier, the ink being liquid at 20° C.Type: ApplicationFiled: November 25, 2019Publication date: March 19, 2020Inventors: Franck Giron, Henri Samain, Geraldine Fack
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Publication number: 20200085705Abstract: The present invention relates to a method of encapsulating an uncharged, soluble, active compound within a self-assembled ionomer complex formed from polyelectrolytes, wherein the said method comprises the steps of mixing a solution comprising at least one polycation and polyanion with active compound, or adding a polyion to a solution comprising an oppositely charged polyion coupled to the active compound, wherein the interaction between the active compound and ionomer complex is non-ionic and non-covalent in nature. The invention also relates to an ionomer complex prepared thereform for use in transport and delivery of the compounds. In a preferred embodiment, the ionomer complex comprises poly-L-arginine, Poly(ethylene oxide)-b-poly(acrylic acid) (PAA-b-PEO), wherein the said ionomer encapsulates 4-methoxyphenyl ?-D-glucopyranoside (MG).Type: ApplicationFiled: December 22, 2017Publication date: March 19, 2020Inventors: Agata Maria Brzozowska, Maria N. Antipina
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Publication number: 20200085706Abstract: A skin improving kit includes a water retentive sheet; and an air-tightly sealed container that is filled with the hydrogen water. A face pack includes a water retentive sheet that has a face shape; and hydrogen water with which at least a surface of the water retentive sheet which comes into contact with a face has been impregnated.Type: ApplicationFiled: September 17, 2018Publication date: March 19, 2020Inventor: Miki MOCHIZUKI
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Publication number: 20200085707Abstract: An oral care composition including a dentifrice and a film suspended in the dentifrice, wherein the film includes charcoal.Type: ApplicationFiled: December 19, 2016Publication date: March 19, 2020Applicant: Colgate-Palmolive CompanyInventors: Zhuoli ZHENG, Yun XU
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Publication number: 20200085708Abstract: The present invention relates to a cosmetic composition for treating keratin fibres, preferably human keratin fibres such as the hair, comprising, in a cosmetically acceptable medium: —one or more chemical oxidizing agents, —one or more scleroglucan gums, —one or more phosphorus-based sequestrants. The present invention also relates to a process for treating keratin fibres, preferably human keratin fibres such as the hair, comprising the application of the composition to the keratin fibres. The process according to the invention is preferably a process for bleaching, dyeing or permanently reshaping keratin fibres.Type: ApplicationFiled: December 19, 2017Publication date: March 19, 2020Inventors: Frédéric SIMONET, Koudedji SOW, Aldo PIZZINO
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Publication number: 20200085709Abstract: The present invention relates to an anhydrous solid composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising one or more metabisulfites. The present invention also relates to a packaging article containing said composition. The present invention also relates to processes for dyeing keratin fibres using said composition or said packaging article. Finally, the present invention also relates to the use of said composition or of said packaging article for dyeing keratin fibres, and in particular human keratin fibres such as the hair.Type: ApplicationFiled: December 19, 2017Publication date: March 19, 2020Inventors: Marie MIGNON, Chrystel POURILLE
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Publication number: 20200085710Abstract: This oily moisturizer is composed of either an esterified product of a component A that is ditrimethylolpropane, and a component B that is one fatty acid, or two or more fatty acids, selected from among saturated fatty acids of 6 to 12 carbon atoms, or an esterified product of the component A, the component B, and a component C that is one fatty acid, or two or more fatty acids, selected from among fatty acids of 13 to 28 carbon atoms, wherein the hydroxyl value of the esterified product is not more than 140 mgKOH/g, and the mass ratio between fatty acid residues derived from the component B and fatty acid residues derived from the component C within the fatty acid residues that constitute the esterified product of the component A, the component B and the component C is within a range from 99.9:0.1 to 60:40.Type: ApplicationFiled: November 22, 2019Publication date: March 19, 2020Applicant: The Nisshin OilliO Group, Ltd.Inventors: Hirofumi DENDA, Tadashiro HIROSE, Hisanori KACHI
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Publication number: 20200085711Abstract: Compositions comprising a lactam and an alkyl lactate. The compositions are suitable for use as anti-microbial, anti-biofilm and bacteriostatic compositions.Type: ApplicationFiled: July 28, 2016Publication date: March 19, 2020Applicant: Conopco, Inc., d/b/a UNILEVERInventors: Paul Damien PRICE, Neil James PARRY
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Publication number: 20200085712Abstract: Provided is a composition containing the following components (A), (B) and (C) and suppressing formation of scum during cleansing, wherein a weight ratio of (A)/(B) is 0.2-5 and a weight ratio of ((A)+(B))/(C) is 0.01-10: (A) N-lauroyl glycine or a salt thereof (B) N-myristoyl glycine or a salt thereof (C) N-acyl acidic amino acid having an acyl group having 8 to 24 carbon atoms, or a salt thereof.Type: ApplicationFiled: November 21, 2019Publication date: March 19, 2020Applicant: AJINOMOTO CO., INC.Inventors: Naoaki Ikeda, Naoya Yamato
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Publication number: 20200085713Abstract: The invention relates to aqueous skin cleansing compositions. Specific amounts and chain length of acyl glycinate and acyl glutamate when used in specified ratios, have been found to unexpectedly enhance lather volume and texture, as well as provide superior mildness.Type: ApplicationFiled: December 13, 2017Publication date: March 19, 2020Applicant: Conopco, Inc., d/b/a UNILEVERInventors: Yeyi GU, Tirucherai Varahan VASUDEVAN, Kayla Marie KEMLER, Adrienne Lyn KING
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Publication number: 20200085714Abstract: The present invention relates to a process for dyeing and relaxing curls of keratin fibres, such as the hair, which comprises the application to the fibres of one or more acidic compositions comprising reducing agents and of one or more compositions comprising hair-dyeing agents, and a step of heat treatment of the fibres by means of a heating tool. A subject of the invention is also the use of the composition(s) comprising reducing agents and of the composition(s) comprising hair-dyeing agents in a process for dyeing and relaxing curls of keratin fibres. Finally, a subject of the invention is a multi-compartment device or “kit” suitable for carrying out such a process.Type: ApplicationFiled: December 22, 2017Publication date: March 19, 2020Applicant: L'OREALInventors: Virginie Burckbuchler, Henri Samain
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Publication number: 20200085715Abstract: A cosmetic ingredient comprising crenatoside and acteoside when applied to the skin is useful to provide cosmetic and perfumery benefits.Type: ApplicationFiled: April 3, 2018Publication date: March 19, 2020Inventors: Fabrice LEFEVRE, Daniel AURIOL, Cyrille JARRIN, Patrick ROBE, Romain REYNAUD
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Publication number: 20200085716Abstract: The present invention relates to the use of a polymer or of a cosmetic product comprising said polymer, and additionally other known cosmetic ingredients, to bring about an anti-pollution effect on human skin or on human hair, especially to protect human skin or human hair from dust, wherein the polymer is a cationic, anionic or non-ionic polymer, and wherein the polymer has a solubility in water of at least 0.01 g of polymer in 100 g of water at 20° C. at least at a pH in the range between 4 and 9.Type: ApplicationFiled: April 13, 2018Publication date: March 19, 2020Inventors: Annette Mehling, Heidi Riedel, Jan Peter Koch, Helga Gondek, Peter Hoessel
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Publication number: 20200085717Abstract: Provided are mild, optically stable, low pH surfactant compositions comprising low molecular weight, non-crosslinked, linear acrylic emulsion copolymers and their use as ocular and/or dermal irritation mitigants in such compositions. The disclosed polymers have a number average molecular wt. of 100,000 Daltons or less, the polymer comprises at least 51 wt. % of polymerized residues of at least one ethylenically unsaturated C3-C6 carboxylic acid monomer, with the remainder of polymerized residues selected from at least one C1-C4 alkyl (meth)acrylate monomer.Type: ApplicationFiled: December 15, 2017Publication date: March 19, 2020Inventors: Krishnan Tamareselvy, Deborah S. Filla, David L. Dashiell
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Publication number: 20200085718Abstract: The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.Type: ApplicationFiled: September 24, 2019Publication date: March 19, 2020Inventors: Arturo J. ANGEL, Larry W. LITLE, Keith R. BLEY, Allan L. WILCOX, Gene C. JAMIESON, Naweed MUHAMMAD
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Publication number: 20200085719Abstract: The present invention relates to a cosmetic composition comprising: at least 10% by weight, relative to the weight of the composition, of water; •at least 10% by weight, relative to the weight of the composition, of at least one silicone resin; •at least one non-volatile silicone oil, not comprising any nitrogen atoms, or any —Si—H groups, or any (poly)oxyalkylene groups, the oxyalkylene unit being C2-C3, or any (poly)glycerol groups; •optionally at least one first non-volatile hydrocarbon-based oil in a content of less than 15% by weight, relative to the weight of the composition; said non-volatile hydrocarbon-based oil(s) being chosen from: —C10-C26 alcohols, preferably monoalcohols; —optionally hydroxylated monoesters, diesters or triesters of a C2-C8 monocarboxylic or polycarboxylic acid and of a C2-C8 alcohol, which are optionally hydroxylated; —esters of a C2-C8 polyol and of one or more C2-C8 carboxylic acids; •optionally, at least one volatile oil in a content such that the silicone resin/volatile oilType: ApplicationFiled: December 21, 2017Publication date: March 19, 2020Applicant: L'OREALInventors: Roshanak DEBEAUD, Sandrine FERNANDES, Roberto CAVAZZUTI
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Publication number: 20200085720Abstract: A composition comprises (A) a silicone elastomer. The (A) silicone elastomer comprises the reaction product of: (a) an organohydrogensiloxane having an average of at least two silicon-bonded hydrogen atoms per molecule; (b) a crosslinking agent having an average of at least two ethylenically unsaturated groups per molecule; and (c) a hydrosilylation catalyst. The reaction product is formed in the in the presence of (d) a silicone polyether polymer; and (e) particles. The composition further comprises (B) a carrier fluid. The (e) particles are dispersed in the (A) silicone elastomer in the composition. A method of preparing the composition is also disclosed.Type: ApplicationFiled: November 8, 2016Publication date: March 19, 2020Inventors: Zhi LI, Bartley D. MAXON, Kimmai T. NGUYEN, Paul W. PRETZER, Kristen E. STEINBRECHER, Lisa M. VANOMMEREN, Evan WADDELL, Fang ZHANG, Kenneth E. ZIMMERMAN
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Publication number: 20200085721Abstract: A thickened composition for a cosmetic product including a content that is taken through a mesh contains a fine particulate powder and a silicone crosspolymer having a structure where dimethicone is cross-linked with an organic group, and has a storage modulus G??3000 Pa, as measured with a rheometer under the conditions of a gap of 0.5 mm, a strain oscillation angle of 0.1%, a frequency of 1 Hz, and a temperature of 25° C. while increasing stress applied with a 25 mm ? cone plate, and a loss tangent tan ??0.2, as calculated as a loss modulus G? measured under the same conditions divided by the storage modulus G?. A cosmetic product includes a container including an inner lid with a tight mesh and an outer lid for tightly closing a container body, and the thickened composition contained in the container body under the inner lid.Type: ApplicationFiled: March 26, 2018Publication date: March 19, 2020Inventors: Keita NISHIDA, Takumi WATANABE, Megumi KINOSHITA
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Publication number: 20200085722Abstract: The present invention thus relates to a solid composition, especially for coating keratin materials, more particularly for making up and/or caring for keratin materials such as the skin, in compact powder form, especially comprising a physiologically acceptable medium and containing at least: —an oily phase in an amount of at least 20% by weight relative to the total weight of the composition; said oily phase comprising at least one non-volatile non-phenyl silicone oil; and —a pulverulent phase in an amount of at least 40% by weight relative to the total weight of the composition; said pulverulent phase comprising at least mica particles; and —at least one amorphous hydrocarbon-based block copolymer; said composition not containing any talc particles that have not been surface-treated and being able to be obtained via a process comprising the following steps: (i) the oily phase, the amorphous hydrocarbon-based block copolymer, the pulverulent phase and the volatile solvent(s) are mixed to form a slurry; and (Type: ApplicationFiled: March 12, 2018Publication date: March 19, 2020Applicant: L'OREALInventors: Anne LIHARD, Anne SIMONNET
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Publication number: 20200085723Abstract: The present invention relates to a composition, especially comprising a physiologically acceptable medium, especially for coating keratin materials, more particularly for making up and/or caring for keratin materials such as the skin, a) an oily continuous phase, and b) at least one mixture of liquid organic UV-screening agents comprising: (i) at least one UV-screening agent of the ?,?-diphenylacrylate type, and (ii) at least one UV-screening agent of the salicylate type; and c) at least one non-cyclic volatile silicone oil; and d) at least one pigment. The invention also relates to a process for coating keratin materials, more particularly for making up and/or caring for keratin materials, such as the skin, characterized in that it comprises the application to the keratin materials of a composition as defined previously.Type: ApplicationFiled: November 24, 2017Publication date: March 19, 2020Applicant: L'OREALInventors: Elodie VALVERDE, Hong LI
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Publication number: 20200085724Abstract: A sunscreen composition having improved water resistance comprising (i) a sunscreen active agent; (ii) a water resistant agent comprising a natural wax having a Damping Factor of less than 1.0 in a linear viscoelastic range at body temperature; and (iii) an emulsifier or a surfactant capable of stabilizing an emulsion of components (i) to (iii), wherein said sunscreen composition maintains at least 75%, preferably at least 85%, and most preferably at least 99%, of its static SPF after water immersion for 4 hours.Type: ApplicationFiled: November 22, 2019Publication date: March 19, 2020Inventors: Hui-Ing Donna Hwang, Alexander Naranjo, Patricia Lynn Scott
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Publication number: 20200085725Abstract: Provided herein are antibacterial and antioxidant oral care formulations. Generally, the oral care formulations contain vinegar, at least one natural extract and sodium bicarbonate in water. Also provided are the antibacterial mouthwash, toothpaste, chewing gum and breath freshener formulations.Type: ApplicationFiled: September 14, 2018Publication date: March 19, 2020Inventor: Prema Latha Bhat
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Publication number: 20200085726Abstract: A method for reducing the appearance of hyperpigmented skin is disclosed. The method can include topically applying to hyperpigmented skin of a person a composition that includes at least one of, at least two of, or all three of (i) an effective amount of Schinus terebinthifolius seed extract, (ii) an effective amount of a mixture comprising Ptychopetalum olacoides bark/stem extract, Pfaffia paniculata root extract, and Trichilia catigua bark extract, and/or (iii) an effective amount of a mixture comprising Himanthalia elongata extract and Undaria pinnatifida extract. Topical application of the composition can reduce the appearance of the hyperpigmented skin.Type: ApplicationFiled: September 18, 2019Publication date: March 19, 2020Inventors: Geetha KALAHASTI, David GAN
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Publication number: 20200085727Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet.Type: ApplicationFiled: September 24, 2019Publication date: March 19, 2020Inventors: BRUNO KAESLER, Rolf KNÖLL, Mewes BOETTNER, Eckhard BUDDE, Christine LANG, Martin RYSER, Markus VEEN
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Publication number: 20200085728Abstract: The present invention is directed to a composition that can be used to deliver an antipsychotic drug such as risperidone, paliperidone or a combination thereof, as an injectable in-situ forming biodegradable implant for extended release providing therapeutic plasma levels from the first day. The composition is in the form of drug suspension on a biodegradable and biocompatible copolymer or copolymers solution using water miscible solvents that is administered in liquid form. Once the composition contacts the body fluids, the polymer matrix hardens retaining the drug, forming a solid or semisolid implant that releases the drug in a continuous manner. Therapeutic plasma levels of the drug can be achieved from the first day up to at least 14 days or more even up to at least four weeks.Type: ApplicationFiled: October 17, 2019Publication date: March 19, 2020Applicant: LABORATORIOS FARMACEUTICOS ROVI S.A.Inventors: Ibon GUTIERRO ADURIZ, Maria Teresa GOMEZ OCHOA
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Publication number: 20200085729Abstract: The invention relates to the prevention and/or treatment of a severe broncho-pulmonary disease by administering a solution formulation from a pressurized metered dose inhaler capable of providing therapeutical doses of two or more active drug substances to the lung, wherein all the active drug substances are fully dissolved in the formulation as well as the two or more active drug substances are delivered with substantially the same particle size distribution.Type: ApplicationFiled: November 20, 2019Publication date: March 19, 2020Applicant: Chiesi Farmaceutici S.P.A.Inventors: David Andrew Lewis, Brian John Meakin, Gaetano Brambilla
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Publication number: 20200085730Abstract: Methods and devices for three-dimensional navigation of magnetic nanoparticles are provided. A method can comprise introducing high-anisotropy magnetic nanoparticles to a mammal and directing the high-anisotropy magnetic nanoparticles towards a target region of the mammal. Direction control is achieved by subjecting the high-anisotropy magnetic nanoparticles to an alternating signal comprising a uniform magnetic field pulse having a strength greater than a coercivity of the high-anisotropy magnetic nanoparticles and a magnetic gradient pulse having a highest strength that is less than the coercivity of the high-anisotropy magnetic nanoparticles and a location of a lowest strength at the target region of the mammal, and the direction of the uniform magnetic field pulse being in an opposite direction of the magnetic gradient pulse.Type: ApplicationFiled: May 21, 2019Publication date: March 19, 2020Applicant: The Florida International University Board of TrusteesInventors: Sakhrat Khizroev, Tiffanie Stewart, Abhignyan Nagesetti
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Publication number: 20200085731Abstract: The present invention relates to stable, liquid parenteral formulations of Melphalan or pharmaceutically acceptable salts thereof. Further this invention also describes process of preparing such formulations.Type: ApplicationFiled: November 25, 2019Publication date: March 19, 2020Applicant: LEIUTIS PHARMACEUTICALS PVT. LTD.Inventors: Kocherlakota CHANDRASHEKHAR, Banda NAGARAJU
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Publication number: 20200085732Abstract: Methods and compositions for providing long term pain relief in, for example, surgery recovery, including injecting a composition comprising a plurality of microparticles having different sizes and at least one local anesthetic loaded into the microparticles at different loading levels. Extended prolonged blockage of nerve action in sheep testing was confirmed. Some of the microparticles comprise a high loading of local anesthetic. Testing in sheep showed nerve blockage for at least six days.Type: ApplicationFiled: August 23, 2019Publication date: March 19, 2020Applicant: CAPSULATED SYSTEMS, INC.Inventors: Roland M. LYNCH, Lwandiko E. MASINDE
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Publication number: 20200085733Abstract: Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic, diagnostic, prophylactic or other agents, to epithelial tissues, especially those having a mucosal coating. The polymers are administered at a concentration above, at or less than their critical gelling concentration (CGC) under isotonic conditions. The hypotonicity of the formulation is adjusted so that the polymer gels at the lower concentration. A Poloxamer gel administered into the vagina or colorectum at its CGC will form a “plug” of gel in the lumen.Type: ApplicationFiled: November 14, 2019Publication date: March 19, 2020Inventors: Katharina Maisel, Laura Ensign, Justin Hanes, Richard Cone
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Publication number: 20200085734Abstract: The invention relates to new pharmaceutical dosage forms containing potent and selective TASK-1 and/or TASK-3 channel inhibitors, and the use of same to treat and/or prevent breathing disorders including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.Type: ApplicationFiled: December 13, 2017Publication date: March 19, 2020Applicant: Bayer Pharma AktiengesellschaftInventors: Johanna ANLAHR, Moritz BECK-BROICHSITTER, Janine NICOLAI, Martina DELBECK, Michael HAHN, Udo ALBUS, Doris GEHRING, Björn ROSENSTEIN
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Publication number: 20200085735Abstract: The invention is directed to delivering therapeutic agents to the eye for the purpose of treating ophthalmic disorders, diseases and injuries. In particular, the invention is directed to delivering therapeutic agents to the eye for the purpose of treating ophthalmic disorders, diseases and injuries by targeted intranasal administration of the therapeutic agents. The invention is specifically directed to treating disorders, diseases and injuries of the cornea and ocular surface, treating retinal disorders, diseases and injuries and optic nerve disorders, diseases and injuries by targeted intranasal administration of the therapeutic agents.Type: ApplicationFiled: November 21, 2019Publication date: March 19, 2020Applicant: Noveome Biotherapeutics, Inc.Inventor: Larry R. Brown
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Publication number: 20200085736Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.Type: ApplicationFiled: November 22, 2019Publication date: March 19, 2020Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
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Publication number: 20200085737Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.Type: ApplicationFiled: November 22, 2019Publication date: March 19, 2020Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
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Publication number: 20200085738Abstract: An avian tincture composition and associated methods for producing the same for treatment of the avian species with the avian tincture. The avian tincture may be used in the treatment of abscesses, inflamed and swollen leg joints, respiratory issues, wounds, infection, and acute disease or parasite overload conditions.Type: ApplicationFiled: November 18, 2019Publication date: March 19, 2020Inventor: Susan Burek
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Publication number: 20200085739Abstract: The present disclosure relates to compositions, including, hydrogel compositions useful as analgesics including cannabinoids, menthol and anesthetic in a composition formulated to be administrable to a non-human animal rectally as a suppository.Type: ApplicationFiled: August 29, 2019Publication date: March 19, 2020Inventor: Babak Ghalili
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Publication number: 20200085740Abstract: The invention relates to the preparation of a water soluble, powdered pharmaceutically active cannabinoid and/or terpene extract from plant materials, a powder where the bulk density can easily be modified depending on the final dosage form required. The extract is first treated with a solvent to solubilize the cannabinoids, then combined with an emulsifier. The solubilized mixture is then dried to evaporate the solvent, leaving the water-soluble cannabinoid extract powder. The resulting powder remaining stable at room temperature for at least one year and can be compounded into various pharmaceutical powdered formulations, with varying bulk powder densities.Type: ApplicationFiled: September 19, 2019Publication date: March 19, 2020Inventor: Scott Karolchyk
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Publication number: 20200085741Abstract: Provided herein are pharmaceutical compositions containing at least one liposome, said liposome comprise an external lipid bilayer including at least one vesicle-forming phospholipid and less than 15 mole % of sterol; and an internal aqueous medium including a weak acid drug and weak acid salt. The pharmaceutical compositions reduce the burst release of the weak acid drug. Also provided is the use of the pharmaceutical composition disclosed herein to treat respiratory diseases and reduce the side effect of the weak acid drug.Type: ApplicationFiled: September 12, 2019Publication date: March 19, 2020Inventors: Pei KAN, Yi Fong LIN, Ko Chieh CHEN
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Publication number: 20200085742Abstract: Nanoscale coordination polymer nanoparticles for the co-delivery of multiple therapeutic agents are described. The multiple therapeutic agents can include a combination of different chemotherapeutic agents, a combination of one or more chemotherapeutic agents and one or more nucleic acids, such as small interfering RNA (siRNA) or microRNA, a combination of one or more chemotherapeutic agents and a photosensitizer (i.e., for use in photodynamic therapy), or a plurality of different siRNAs. Pharmaceutical formulations including the nanoparticles, methods of using the nanoparticles to treat cancer, and methods of making the nanoparticles are also described.Type: ApplicationFiled: September 20, 2019Publication date: March 19, 2020Inventors: Wenbin Lin, Chunbai He, Demin Liu
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Publication number: 20200085743Abstract: Disclosed herein are glucose-sensitive drug delivery systems including polymeric shell encapsulating an active agent. Upon exposure to a sufficient concentration of glucose, the shell is ruptured, releasing the active agent for absorption.Type: ApplicationFiled: June 4, 2018Publication date: March 19, 2020Inventors: Zhen GU, Jicheng YU
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Publication number: 20200085744Abstract: Method for preparing a stable controlled-release propolis colloidal dispersion system, wherein propolis is micronized and then dispersed in the solvent system, which is under stirring and consists of deionized water and either natural 1,3-propanediol or glycerol, in which deionized water hydroxypropyl-?-cyclodextrin or ?-cyclodextrin has been predissolved, and as the propolis/cyclodextrin/solvents system is under intense stirring for 30-45 min, a liposomal suspension is added thereto, and stirring is performed for 1 to 4 hours under continuous measurement of the total content in polyphenols and of the encapsulation efficiency %, until the specific parameters reach the desired values so that the stirring process is ended and the colloidal system is filtrated through suitable filters, its pH is adjusted and the size of dispersed particles as well as the release rate of the polyphenols of propolis in a buffer solution at pH 7.2 and 37° C. are measured and the colloidal system is stored.Type: ApplicationFiled: November 23, 2015Publication date: March 19, 2020Inventors: Konstantinos GARDIKIS, Nikolaos KOUTSIANAS, Anna Patera, Panagiota DRAGANI, Anagnostis-Ioannis TSOUKALAS, Sofia LETSIOU
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Publication number: 20200085745Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.Type: ApplicationFiled: August 28, 2019Publication date: March 19, 2020Inventors: Shrirang Karve, Zarna Patel, Yi Zhang, Ashish Sarode, Rebecca L. Ball, Frank DeRosa, Michael Heartlein
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Publication number: 20200085746Abstract: The present invention relates to mannitol granules that are of use for the preparation of tablets by direct compression, which do not require a small amount of lubricant in order to be processed. The present invention also relates to a process for preparing such granules. The present invention also encompasses pulverulent compositions comprising these granules, and also direct compression processes using these pulverulent compositions. Finally, the present invention relates to tablets composed of these pulverulent compositions.Type: ApplicationFiled: July 15, 2016Publication date: March 19, 2020Inventors: Baptiste Boit, Philippe Lefevre
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Publication number: 20200085747Abstract: A method for blood plasma protein activity preservation is provided. The method comprises the steps of mixing blood plasma with two or more protectants selected from the group consisting of triglyceride, glycerol, propylene glycol, alanine, serine, glycine, alginate, and sucrose to obtain a mixture; and lyophilizing the mixture.Type: ApplicationFiled: December 21, 2016Publication date: March 19, 2020Inventors: Cheng-Yao SU, Chung Chin SUN, Shan Shue WANG
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Publication number: 20200085748Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.Type: ApplicationFiled: November 20, 2019Publication date: March 19, 2020Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
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Publication number: 20200085749Abstract: The present disclosure relates generally to rapid-release pharmaceutical dosage unit tablets containing a drug that is an inhibitor of the mitogen-activated protein kinase enzyme, a filler and a disintegrant, and to processes for forming the tablets. More specifically, the present disclosure relates to pharmaceutical dosage unit tablets containing cobimetinib, a least one filler, at least one lubricant and at least one disintegrant, and to methods for preparing the tablets from granules formed by dry granulation.Type: ApplicationFiled: November 15, 2019Publication date: March 19, 2020Applicant: Genentech, Inc.Inventors: Sanjeev Kothari, Priscilla Mantik, Alexander Mauerer, Hamid Rezaei