Abstract: Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said glycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

Abstract: This invention relates to the use of a heparanase inhibitor for treating, or inhibiting the progression or development of, an ocular inflammatory disorder, such as age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, retinal 5 vein occlusion, retinoblastoma, uveitis, macular edema, dry eye, ocular inflammation associated with an infection or keratoconus.

Abstract: The present invention is directed to a composition containing at least one salt and at least one natural or synthetic high molecular weight, non-ionic, hydrophilic polymer. When in a liquid form, the composition is ready for infusion or injection to patients that suffer from loss of fluids that causes reduced volume and/or pressure in the systemic circulation. The composition is also suitable for treatment of organ conditions where blood flow is impaired or insufficient, resulting in organ distress, including tissue loss. The invention also relates to use as a prophylaxis to prevent medical consequences of anticipated conditions where depleted circulatory fluids, low blood pressure, or impaired organ perfusion require correction.

Abstract: Compositions and methods for the treatment or prevention of an ocular disease in an eye of a patient. The petrolatum-based compositions may include petrolatum and a saline solution comprising at least one cationic biocide. In at least some instances, the compositions do not require the use of an added emulsifier and may contain at least one antiviral agent. Methods of using the petrolatum-based compositions in the treatment of ocular diseases, including infections of the eye are provided. Additionally, processes for preparing such compositions are provided.

Abstract: The present invention relates to compositions and methods useful for immune activation that is effective for eliciting a non-antigen-specific immune response in a subject. An immunomodulator composition can include a therapeutically effective amount of a liquid nitric oxide releasing solution (NORS) for eliciting an immune response in a subject to treat an adverse health condition in the subject.

Abstract: The present application provides a composition for improving depressive symptoms in a human, comprising hydrogen as an active ingredient, and a method for improving depressive symptoms in a human having depressive symptoms, comprising administering the composition to the human.

Abstract: In a method of treating a patient having low blood flow that may be caused by diffused plaque and/or a plaque mass associated with Peyronie's disease in a penile region, a predetermined amount of carbon dioxide is injected into affected corpus cavernosum at a location that is adjacent to, but spaced away from the plaque mass. In addition, either before and/or after the injection of the carbon dioxide, a decalcifying agent(s) may be injected directly into the plaque mass.

Abstract: This present disclosure discloses a bioadhesive boric acid formulation and its use and preparation method. Specifically, a preferred vaginal bioadhesive boric acid formulation mainly comprises of: methylparaben, propylparaben, potassium sorbate, chitosan, glycerin, carbopol 974, polycarbophil, boric acid, and purified water. The vaginal boric acid preparation are capable of retaining and releasing boric acid in the vagina. It is proved experimentally that boric acid acts as an antibacterial component of this gel and can be maintained at a relatively high concentration in vaginal fluid. Further, it is demonstrated that the vaginal bioadhesive boric acid formulation has a dynamic viscosity >100000 cps, pH value of 2-5, good moisture retention capability. The formulation is non-allergenic, non-vaginal irritation, and capable of inhibiting bacteria and fungi.

Abstract: The present invention is a method of producing a lanthanum carbonate hydroxide or lanthanum oxycarbonate which has improved properties. The method involves the use of a water soluble lanthanum and a water soluble non-alkali metal carbonate or bicarbonate. The resulting material can be used as a phosphate binder individually or for treating patients with hyperphosphatemia.

Abstract: The present invention generally relates to antigen binding receptors capable of specific binding to mutated Fc domains with reduced Fc receptor binding and T cells expressing these antigen binding receptors. More precisely, the present invention relates to T cells, transfected/transduced with an antigen binding receptor which is recruited by specifically binding to/interacting with the mutated Fc domain of therapeutic antibodies. Furthermore, the invention relates to a kit comprising the T cells of the invention and/or nucleic acid molecules, vectors expressing antigen binding receptors of the present invention and (a) tumor targeting antibody/antibodies comprising a mutated Fc domain.

Abstract: The present invention generally relates to antigen binding receptors in new formats capable of specific binding to a tumor associated antigen. More precisely, the present invention relates to an antigen binding receptor which efficiently and specifically binds to/interacts with an antigen on the surface of a tumor cell, and to a T cell transfected/transduced with the antigen binding receptor. Furthermore, the invention relates to nucleic acid molecules and vectors encoding antigen binding receptors of the present invention. The invention also provides the production and use of T cells in a method for the treatment of particular diseases as well as pharmaceutical compositions/medicaments comprising antigen binding receptors and/or T cells of the present invention.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: Provided herein are modified NK-92® cells comprising one or more nucleic acids encoding i) a homing receptor, ii) Antigen Binding Protein (ABP) or Chimeric Antigen Receptor (CAR) that specifically binds to a target antigen, iii) an Fc Receptor such as CD16 or CD16-158V, and/or iv) a cytokine, wherein the nucleic acid sequence is operably linked to a promoter. Further provided herein are modified NK-92® cells comprising one or more nucleic acids encoding i) IL-12 and/or TGF-beta trap, ii) an Antigen Binding Protein (ABP) or Chimeric Antigen Receptor (CAR) that specifically binds to a target antigen, iii) an Fc Receptor such as CD16 or CD16-158V, and/or iv) a cytokine, wherein the nucleic acid sequence is operably linked to a promoter. Also provided are compositions and kits comprising the modified NK-92® cells, as well as methods of treating cancer using the modified cells.

Abstract: Novel modified stem cells activated as a carrier for thioretinaco and thioretinamide in the form of mitochondrial thioretinaco ozonide oxygen nicotinamide adenine dinucleotide phosphate are provided for the prevention and treatment of cancer, arteriosclerosis, dementia, autoimmune and other degenerative conditions involving increased levels of homocysteine. Methods for the production of the novel modified stem cells and their use are also provided.

Abstract: Genetically engineered hematopoietic cells such as hematopoietic stem cells having one or more genetically edited genes of lineage-specific cell-surface proteins and therapeutic uses thereof, either alone or in combination with immune therapy that targets the lineage-specific cell-surface proteins.

Abstract: A composition of matter for an analgesia and its method of use is disclosed. The composition comprises selected single cobrotoxin molecule which is characterized by its high affinity binding to nicotinic acetylcholine receptors, rapid onset, and better safety profile comparing to a cobrotoxins complexes. The method of use is for the treatment of pain, especially for the treatment of refractory pain as associated with advanced cancer, rheumatoid arthritis, chronic neuropathic, migraine, and viral infections.

Abstract: A combination or composition of mussel lipid and krill oil is disclosed, which is used to treat inflammation or pain. A process for preparing hill oil having a phospholipid content of about 50% or greater is also disclosed.

Abstract: Provided are: a method of producing a therapeutic agent for skin lesions suitable for treatment or prevention of a skin lesion such as a bedsore; and a therapeutic agent for skin lesions produced by the production method. The method of producing a therapeutic agent for skin lesions characterized by including a mixing step of mixing earthworm castings with water and a collecting step of collecting vaporized water generated from a mixture obtained in the mixing step to obtain a liquid; and the therapeutic agent for skin lesions produced by the production method. It is preferred to further mix an organic substance together with the earthworm castings and the water in the mixing step.

Abstract: A lip-care lipstick with a repair effect relates to the technical field of daily necessities. The present invention aims to provide a lip-care lipstick with a repair effect. The lip-care lipstick includes the following components in parts by weight: 3-5 parts by weight of the Manuka honey containing the ME lip-care factor, 3-5 parts by weight of the royal jelly, 0.1-1 part of dipropylene glycol, 0.5-1.5 parts of allantoin, 22 parts by weight of the sodium hyaluronate, 15 parts by weight of polyglyceryl-2 diisostearate, 10 parts by weight of dipentaerythrityl hexahydroxystearate, 10 parts by weight of ethylhexyl palmitate, 8 parts by weight of tridecyl trimellitate, 5 parts by weight of avocado butter, 10 parts by weight of beeswax, 0.9 part by weight of tocopheryl acetate, 0.1 part by weight of methylparaben, 6 parts by weight of colorant and 5 parts by weight of other plant essential oils.

Abstract: The present invention relates to, in part, compositions and methods for delivery of novel mixtures of bacterial strains for the decolonization and/or eradication of various pathogenic bacteria and, particularly, antibiotic-resistant bacteria (ARB).

Abstract: Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.

Abstract: The invention provides compositions of oligofructose and specific digestive tract microbes useful for mitigating the negative effects of obesity and/or type 2 diabetes on osteoarthritis, bone fracture healing and immune system function, and methods of preparation and use thereof.

Abstract: The present invention provides methods of treating or preventing gestational diabetes by administering Lactobacillus rhamnosus HN001 or derivatives thereof, in addition to uses, compositions, and medicaments comprising Lactobacillus rhamnosus HN001 or derivatives thereof to treat or prevent gestational diabetes mellitus.

Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a Serine Protease Inhibitor Kazal-type (SPINK) polypeptide (e.g., a SPINK5 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of Netherton Syndrome); and articles of manufacture or kits thereof.

Abstract: There is a composition comprising an essential oil, namely a cannabis essential oil that is compatible with a prophylactic such as a condom. The cannabis essential oil comprises an active ingredient, tetrahydrocannabinol, which heightens the sensation and causes a euphoric feeling during intimate relations. There is a kit allowing for easy access to both the essential oil and condom that comprises two chambers, one chamber for storing the essential oil and the second chamber for storing the condom. The two chambers are easily separable by tearing along the perforated portion. There is a packet comprising two separable chambers for storing the composition comprising the essential oil and a prophylactic.

Abstract: Methods of removing contaminants such as pesticides, herbicides, and fungicides from plant-derived pharmaceuticals, such as cannabis-derived pharmaceuticals, are disclosed. Plant-derived pharmaceuticals, such as cannabis-derived pharmaceuticals, and methods of using the plant-derived pharmaceuticals are also disclosed.

Abstract: The present invention relates to a Petasites extract or pharmaceutical composition thereof for use in a method for treating viral infections.

Abstract: A synergistic herbal stimulant composition comprises a mixture, in powdered or extract form, of two or more herbal stimulant ingredients and at least one catalytic herbal ingredient, which effects a synergy between the herbal stimulant ingredients. The herbal stimulant ingredients are preferably selected from the group consisting of Horny Goat Weed (Epimedium Sagittatum), Rhodiola Root (Rhodiola Rosea), Elueuthero Root (Eleutherococcus), Nettle Leaf (Urticaria Dioica), Ashwagandha Root (Withania Somnifera), Maca Root (Lepidium Meyenii), Moringa Root (Moringa Oleifera), and Cowitch (Macuna Pruriens). The catalytic herbal ingredient is preferably Moses-in-a-basket (Tradescantia Spathacea).

Abstract: The invention relates to a use of Copaifera oleoresin for producing a medicament for preventing and/or treating pathologies of the prostate, particularly benign prostatic hyperplasia and/or prostate cancer.

Abstract: Methods of treating or preventing at least one sign or symptom of restless leg syndrome or related disorders are disclosed. The methods comprise identifying a host, afflicted with restless leg syndrome or related disorders; and administering to the host a pharmaceutically effective amount of a fruit of Ficus carica plant or an extract thereof. Also provided are methods and compositions for treating or preventing sleep disorders, and methods and compositions for improving sleep adequacy and quantity.

Abstract: The invention is directed to a composition formulated from green tea flower and methods for making and using the composition in the management of body weight.

Abstract: A method to manufacture a vaginal lubricant comprising combining water, aloe vera, disodium EDTA, sodium benzoate, potassium sorbate, and a phosphate buffer thereby forming a first phase solution. The heated first phase solution is cooled to thereby form a cooled first phase solution. Raw honey and the cooled first phase solution are combined to thereby form a second phase solution. Polysorbate 20 and a honey flavoring are combined to thereby form a fragrance phase solution. The fragrance phase solution and the second phase solution are combined to thereby form a third phase solution. The first phase solution includes 99.17% water, 0.219% aloe vera, 0.0547% disodium EDTA, 0.219% sodium benzoate, 0.219% potassium sorbate, and 0.01095% phosphate buffer. The second phase solution includes 8.065% raw honey. The fragrance phase solution includes 71.42% polysorbate 20 and 28.571% honey flavoring. The third phase solution includes 0.5% polysorbate and 0.2% honey flavoring.

Abstract: The present invention relates to the use of novel JNK inhibitor molecules and their use in a method of treatment of the human or animal body by therapy.

Abstract: The application describes stable aqueous compositions comprising relatively high concentrations of carbetocin and a solubilizer and/or surface active agent. The disclosed carbetocin compositions are effective in the treatment of a neurodevelopmental disorder, such as Präder-Willi syndrome. Additionally, the disclosed carbetocin compositions show improved stability at room temperature and/or under accelerated conditions of stress.

Abstract: The present disclosure includes a method of making an improved carbetocin drug product. The disclosed method for making an improved carbetocin drug product comprises agitating a carbetocin preparation containing an aqueous solution of carbetocin and one or more excipients for a period of time to initiate the formation of aggregate-forming solids and filtering off the aggregates that form before further processing the remaining carbetocin into a final drug product. The present disclosure also relates to an improved carbetocin drug product, wherein the drug product is substantially free of aggregate-forming solids. The disclosed carbetocin drug product can be used for the treatment of a neurodevelopmental disorder, such as Präder-Willi syndrome. Additionally, the disclosed carbetocin drug product shows content uniformity of carbetocin over long periods of time before and after one or more freeze/thaw cycles, provides enhanced convenience and patient compliance, and/or are highly concentrated.

Abstract: The present disclosure relates to novel lantibiotics, lantibiotic pharmaceutical compositions, isolated and recombinant lantibiotic-producing bacteria, bacterial pharmaceutical compositions, methods of producing novel lantibiotics from lantibiotic-producing bacteria, and methods of using such lantibiotics, lantibiotic pharmaceutical compositions, and bacterial pharmaceutical compositions to treat gram-positive bacteria infections, including vancomycin resistant enterococci infections, in patients, and to treat food and other objects to avoid gram-positive bacteria contamination.

Abstract: An ophthalmic treatment composition for the treatment of dry eye consists essentially of squalane in an amount by weight of 1% to 100%; and mineral oil in an amount by weight of 0% to 99%. Preferably, the mineral oil is a light mineral oil or mixture of light mineral oils and is present in an amount by weight of 1% to 10%. The composition is effectively devoid of water, preservatives, emulsifiers and dispersing agents. A related ophthalmic treatment composition comprises squalane in an amount by weight of 1% to 99% and mineral oil in an amount by weight of 0% to 99% and at least one hydrophobic or lipophilic pharmaceutical substance in an amount by weight of 0.01% to 5%, effective for treatment of at least one ophthalmic condition.

Abstract: The present invention relates to novel labyrinthopeptin derivatives. These labyrinthopeptin derivatives are useful for the treatment of infectious diseases, such as an infectious disease caused by an infection with human respiratory syncytial virus (RSV), Kaposi sarcoma-associated herpesvirus (KSHV), cytomegalovirus (CMV/HCMV), dengue virus (DENV), chikungunya virus (CHIKV), tick-borne encephalitis virus (TBEV; FSME virus), vesicular stomatitis Indiana virus (VSV), zika virus (ZIKV) and/or hepatitis C virus (HCV). Said labyrinthopeptin derivatives are also useful for analyzing the mode of action of labyrinthopeptins. Also encompassed by the present invention are labyrinthopeptins for use in treating an infectious disease, in particular an infectious disease caused by an infection with any one of the viruses selected from RSV, KSHV, CMV, CHIKV, TBEV, VSV, ZIKV and HCV. The invention further relates to a combination of labyrinthopeptin A1 and A2 for use as a medicament, e.g.

Abstract: The present invention relates to novel fragments of AIMP1 protein and a composition for improving alopecia and promoting hair growth comprising the same, more specifically it relates to a polypeptide consisting of 4 to 21 consecutive amino acids from the amino acid sequence of SEQ ID NO: 1, wherein the polypeptide comprises the 28th to 31st amino acid residue (KEKA) of amino acid sequence of SEQ ID NO: 1, or a polypeptide consisting of an amino acid sequence having 70% or more sequence homology with the polypeptide; a polynucleotide encoding the polypeptide; a pharmaceutical, cosmetic and food composition for improving alopecia and promoting hair growth comprising the polypeptide.

Abstract: A method inhibiting and/or reducing ?-amyloid accumulation and/or Tau aggregation in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases.

Abstract: The present disclosure provides compositions and methods for treatment of a kidney disease with chemokine protein stromal cell-derived factor 1 (SDF-1), such as methods of treating a subject afflicted with or at risk of developing a kidney disease, comprising administering SDF-1 to a kidney of the subject in a treatment-effective amount.

Abstract: This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.

Abstract: The present invention relates to improved assisted reproductive technology using highly purified menotropin (HP-hMG) to stimulate follicle development in controlled ovarian stimulation, particularly in women at risk of a high ovarian response to controlled ovarian stimulation.

Abstract: The present invention relates inter alia to an aqueous liquid pharmaceutical formulation comprising (i) an insulin compound, (ii) ionic zinc, (iii) a nicotinic compound (iv) a non-ionic surfactant; and (v) a salt selected from the salts formed between Group 1 metals and a mono or divalent anion. It also provides related methods, uses and pharmaceutical compositions.

Abstract: The present invention relates inter alia to an aqueous liquid pharmaceutical formulation comprising: (i) an insulin compound; (ii) ionic zinc; (iii) a zinc binding species at a concentration of 1 mM or more selected from species having a log K with respect to zinc ion binding in the range 4.5-10 at 25° C.; (iv) a zinc binding species selected from species having a log K with respect to zinc ion binding of more than 12.3 at 25° C. at a concentration of less than about 0.3 mM; and (v) a non-ionic surfactant. It also provides related methods, uses and pharmaceutical compositions.

Abstract: The invention relates to a pharmaceutical composition comprising between 10 and 30 g/l of fibrinogen, between 10 and 300 mM of arginine and between 10 and 300 mM of glutamate. In addition, the pH of the composition is between 6 and 8.

Abstract: A method for detecting whether glucose metabolism is abnormal comprises: detecting GPx2 gene expression, GPx2 protein expression or the activity of GPx2 protein in a test body, and making comparisons with GPx2 expression amount of a normal individual, when the GPx2 expression of the individual is significantly lower than that of the normal individual, indicating that the carbohydrate metabolism of the individual is in an abnormal state. Applications of GPx2 in the preparation of a medical composition for the treatment and prevention of type II diabetes.

Abstract: The present disclosure provides a method of treating seizure in a subject having aberrant alkaline phosphatase activities, comprising administering a therapeutically effective amount of at least one recombinant alkaline phosphatase to the subject.

Abstract: A Hunter syndrome therapeutic agent contains a first composition to be intravenously injected and a second composition to be subcutaneously injected. The agent can reduce the number of visits to the hospital by patients with Hunter syndrome to twice a month or less. It maintains a medicinal effect equivalent to or greater than that of a conventional once-a-week IV injection, increases drug-taking compliance of patients in comparison to conventional therapeutic agents and treatment methods, and enables enhanced patient welfare and convenience.

Abstract: The present invention provides compositions and methods for regulating pancreatic beta cell function through modulation of adipsin activity and/or expression. Also provided are methods for preventing, treating, diagnosing, and prognosing metabolic disorders, such as diabetes, in a subject through modulation or detection of adipsin activity and/or expression.