Abstract: A gas therapy system (1) has a flow line (3, 2), a coupler (6) to a gas source, and an aerosol generator (4) for aerosol delivery, and a patient interface such as a nasal interface (2). A controller (10) is configured to modulate gas flow and aerosol delivery in real time. The controller changes gas flow rate and dynamically reduces aerosol delivery during upper gas flow rates such as 60 LPM, and activates aerosol delivery during lower gas flow rates of for example 10 LPM. The control may also include sensors to detect breathing, so that there is a bias towards increased aerosol delivery during inhalation in addition to during lower level gas flow.

Abstract: New medical circuit components and methods for forming such components are disclosed. These components include microstructures for humidification and/or condensate management. The disclosed microstructures can be incorporated into a variety of components, including tubes (e.g., inspiratory breathing tubes and expiratory breathing tubes and other tubing between various elements of a breathing circuit, such as ventilators, humidifiers, filters, water traps, sample lines, connectors, gas analyzers, and the like), Y-connectors, catheter mounts, humidifiers, and patient interfaces (e.g., masks for covering the nose and face, nasal masks, cannulas, nasal pillows, etc.), floats, probes, and sensors in a variety of medical circuits.

Abstract: An apparatus for humidification of air to be delivered to a patient's airways may include a reservoir, and a humidifier chamber. The humidifier chamber may include a humidifier wick and a heating element for heating the humidifier chamber. The humidifier wick may comprise a fibrous sheet material. The humidifier chamber and wick may be vertically oriented in use such that a first end of the wick is above the second end of the wick. A deioniser may be provided to deionise the liquid prior to the humidifier wick. The apparatus may pasteurise liquid to be delivered to the humidification wick.

Abstract: Adaptive modification and presentment of user interface elements in a computerized therapeutic treatment regimen. Embodiments of the present disclosure provide for non-linear computational analysis of cData and nData derived from user interactions with a mobile electronic device executing an instance of a computerized therapeutic treatment regimen. The cData and nData may be computed according to one or more artificial neural network or deep learning technique to derive patterns between computerized stimuli or interactions and sensor data. Patterns derived from analysis of the cData and nData may be used to define an effort metric associated with user input patterns in response to the computerized stimuli or interactions being indicative of a measure of user engagement or effort. A computational model or rules engine may be applied to adapt, modify, configure or present one or more graphical user interface elements in a subsequent instance of the computerized therapeutic treatment regimen.

Abstract: A head mounting system for therapeutic vibration is provided. The head mounting system includes first and second arms configured to support first and second movable vibration generating pads, respectively. The first and second movable vibration generating pads may be movable along tracks that are integrally formed on the inner sides of the first and second arms. The head mounting system further includes a headband dimensioned to engage a crown of a patient head. The headband includes a first end, a second end, and a power source positioned between the first end and the second end and is configured to supply vibrational power to the first and second movable vibration generating pads. The first and second arms extend laterally away from the first and second ends of the headband, respectively, and are configured to engage first and second sides of a patient face.

Abstract: Apparatus and methods for producing narrow-band radiation in the green region of the visible spectrum are described. The narrow-band radiation may be used to aid subjects experiencing photophobia. In some cases, subjects may experience a reduction in pain (e.g., migraine photophobia) when using the narrow-band radiation.

Abstract: A delivery system for an intracorporeal device includes a sheath defining one or more lumens shaped to receive a delivery catheter or shaft and a guidewire. The system may include a delivery shaft having a distal coupling feature adapted to releasably couple with a proximal coupling feature of the intracorporeal device. The delivery system may further include a hub through which the delivery shaft and guidewire are passed. The delivery shaft may be coupled to a feature, such as a knob, that enables manipulation of the delivery shaft to decouple the distal fixation feature from the proximal fixation feature of the intracorporeal device in order to deploy the intracorporeal device within a patient.

Abstract: A method of making an ultrasonic catheter, disposing an ultrasound member in the main lumen of a flexible catheter body; providing an intermediate member and a tip, wherein at least a tip maximum-diameter portion is disposed in the intermediate member, wherein an intermediate-member outer diameter substantially matches a main lumen inner diameter, and wherein a tip distal cross-section has a tip distal cross-section area less than a tip proximal cross-section area of a tip proximal cross-section; and attaching the intermediate member to the catheter body and to the tip, wherein at least one of the tip and the intermediate member is configured to prevent separation of the tip of the ultrasound member from the catheter body.

Abstract: A surgical access assembly and method of use is disclosed. The surgical access assembly comprises an outer sheath and an obturator. The outer sheath and obturator are configured to be delivered to an area of interest within the brain. Either the outer sheath or the obturator may be configured to operate with a navigational system to track the location of either device within the brain.

Abstract: An apparatus includes a first catheter defining a first longitudinal axis and a first lumen. A first actuator can be coupled to the first catheter and configured to rotate about the first longitudinal axis to deflect a distal end of the first catheter relative to the first longitudinal axis. A second catheter can define a second longitudinal axis and a second lumen. At least a portion of the second catheter can be configured to slide within the first lumen. A magnetic member can be coupled to a distal end of the second catheter. The magnetic member can define a third lumen. The third lumen can be in fluid communication with the second lumen. A second actuator can be coupled to the second catheter and configured to move linearly along the second longitudinal axis so as to vary a spacing between the magnetic member and the first catheter.

Abstract: The disclosed technology is directed to a catheter comprises a catheter main body. A sheath covers the catheter main body and is movable along the longitudinal axis with respect to the catheter main body. An operating unit is disposed at a proximal end portion of the sheath and is used to move the sheath and the catheter main body with respect to one another. The catheter main body includes a slit that is formed in an outer peripheral surface of a distal end portion and extends along the longitudinal axis from a slit distal end to a slit proximal end side. An outside diameter of the distal end portion of the catheter main body is larger than an inside diameter of a distal end portion of the sheath in a state in which the distal end portion of the catheter main body is housed in the sheath.

Abstract: Some embodiments of a medical system include a subcutaneous anchor device that extends outwardly from side wall of an intravenous cannula so as to secure the intravenous cannula in a position relative to a skin penetration point.

Abstract: An insertion device is disclosed. The insertion device includes a base portion, a top portion slidably connected to the base portion, an introduction needle, a catheter in slidable relation to the introduction needle, and a substantially cylindrical flash chamber, the flash chamber having an inlet in fluid communication with the introduction needle. The flash chamber is connected to the base portion, the top portion slidably engages with the flash chamber, and the catheter and the top portion slidably advance with respect to the introduction needle and the base portion.

Abstract: A catheter for guiding a body fluid of a subject includes an elongated body, an adjusting mechanism, and a valve mechanism. Moreover, the elongated body further includes a first portion, a second portion and a flexible portion between the first and the second portions. The second portion includes a passageway for the body liquid. The valve mechanism closes to the inlet of the passageway. Furthermore, the flexible portion expands when the adjusting mechanism is in a first state to prevent the catheter from being removed from the subject, and the flexible portion retracts when the adjusting mechanism alters to a second state to allow the catheter to be removed from or inserted into the subject. Hence, the body fluid is directed to enter the passageway via the inlet and exit via the outlet when the adjusting mechanism is not in the second state.

Abstract: A device that includes a body having an opening through which a wire is configured to extend; a channel defined by an upper wire guiding portion and a lower wire guiding portion; and a wire locking feature configured to immobilize a section of the wire. The channel is configured to guide the wire along a path between the body and the wire locking feature.

Abstract: A device that includes a body, a wire locking feature, and a channel. The body has an opening through which a wire is configured to extend. The channel is defined by an upper wire guiding portion and a lower wire guiding portion. The channel is configured to guide the wire between the opening and the wire locking feature. The upper wire guiding portion includes a protrusion. The wire is configured to slip past the protrusion during insertion of the wire into the channel.

Abstract: The disclosure is directed to a targeting guidewire. The guidewire includes a distal portion including four portions and three transition zones between the adjacent portions. A first and a third portions have a smaller stiffness than a second and a fourth portions. The first and the third portions may also have a smaller overall outer diameters than the second and the fourth portions. The three transition zones comprises marking elements so as to delineate their locations.

Abstract: A guidewire configured to reduce the incidence of medical accidents when using guidewires including, but not limited to, the incidence of guidewires accidentally being pushed completely into a patient through a needle in the patient, guidewires accidently being left inside patients after the placement of central venous (and other) catheters, and guidewires accidently being left inside patients after removal of the catheter (at the end of an operation of other medical procedure). In particular, an intermediary portion (in the form of a new shape (referred to herein as “an obstruction portion”), an impeding portion, or an alternate (e.g., more flexible) material) of the guidewire inhibits further advancement into the needle with pushing motion. (The intermediary portion can be implemented as an additional portion connected between the patient-side portion and the doctor-side portion of the guidewire as well.

Abstract: A non-compliant medical balloon may be changed from a deflated state to an inflated state by increasing the internal pressure within the balloon. The balloon comprises a balloon layer having an outer surface, the balloon layer including a base layer, a first reinforcing layer and a second reinforcing layer. The base layer is formed of a polymer material. The first reinforcing layer is one of either a plurality of discrete inelastic fibers oriented substantially parallel to the long axis of the balloon and a first layer of textile fabric material, the textile fabric material being one of a woven, knitted, braided and non-woven fabric. The second reinforcing layer is one of either at least one inelastic fiber wrapped around the circumference of the balloon substantially transverse to the long axis of the balloon and a second layer of textile fabric material, the textile fabric material being one of a woven, knitted, braided and non-woven fabric.

Abstract: Devices and methods for trimming a stent to a desired length with an outer tube and an inner tube having a distal end and a diameter configured to receive a portion of the stent in excess of the desired length. The inner tube may move within the outer tube and the distal end may include an end effector configured to trim the portion from the stent while the device and stent are within a patient.

Abstract: Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.

Abstract: Devices and methods are provided for use in the treatment of bladder cancer by locally administering oxaliplatin into the bladder of a patient to achieve a sustained concentration of oxaliplatin in urine in the bladder sufficient to produce a therapeutic concentration of oxaliplatin in bladder tissue. The oxaliplatin may be delivered into the bladder from an intravesical drug delivery device inserted into the bladder, wherein the device continuously releases the oxaliplatin into the urine in the bladder over an extended period of hours or days.

Abstract: Method for targeted application of active agents to a target surface including: creating a digital geometric representation of the target surface; providing an array of applicators; selecting an applicator from the array of applicators based on the target surface; disposing the active agent on the applicator surface of the applicator; disposing the applicator on the target surface so that the active agent is in contact with the target surface; and removing the applicator from the target surface while leaving at least some of the active agent in contact with the target surface.

Abstract: An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The invention is well-suited for delivering pharmaceuticals to patients transdermally. In some embodiments, the system includes two separate reservoirs and a mixing area thereby allowing precursors to be mixed immediately before transdermal delivery.

Abstract: There currently exists no needle capable of delivering pharmaceutical or cosmetic ingredient(s) into deep layers of integumental tissue (e.g. skin, scales, bark), nor any needle device designed to facilitate the precise administration of a desired dose, and to limit inflammation, pain, and other side effects associated with the needle(s). The present invention relates to an integumental dissolving needle—which houses micronized cosmetic/pharmaceutical ingredient(s), encapsulated by a coating agent absorbed into the integument—arranged on the surface or surfaces of a poultice. Needle thickness and length may be varied according to the biological species of interest. In addition, dosage(s) is/are printed on each section of the device to make explicit how many milligrams of the ingredient are present per unit area; these sections may be separated from one another along groove(s) or other markers on the device. The present invention is a needle device consisting of the above components.

Abstract: A magnetically driven tattoo machine is disclosed, which has a substantially radially symmetric exterior shape and be driven by a sensor-controlled electromagnetic coil. The machine has no oscillating mechanical components, and thus reduces or eliminates vibration. The machine may include a housing mechanically isolated from a needle cartridge or subcomponents that can be disassembled and sterilized. The electromagnet may be controlled by a sensor integral with the coil, housed within the machine, or within an external power supply. The machine may be powered by internal battery or by an external power source. The machine may also be controlled wirelessly.

Abstract: A multi-use disposable set (MUDS) has at least one syringe having a proximal end and a distal end spaced apart from the proximal end along a longitudinal axis. The MUDS further has a plunger reciprocally movable within a syringe interior between the proximal end and the distal end. A manifold is in fluid communication with the distal end of the at least one syringe. At least one valve is in fluid communication with the syringe interior. The at least one valve is operable between a filling position for filling the syringe interior with fluid and a delivery position for delivering the fluid from the syringe interior. At least one connection port is in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position. A multi-fluid delivery system having the medical connector and MUDS is also provided. Various features of the MUDS system are also described.

Abstract: This adaptor comprises a tubular body having a proximal region and a distal region, the proximal region configured to engage a distal tip of said drug delivery device and the distal region being configured to be connected to the connector. The distal region has a distal end delimiting a distal opening so as to permit introduction of the connector inside the distal region. The distal end is configured to be clamped to the connector when said connector is introduced inside the tubular body. The distal end comprises a deformable element having a free end which is configured to deform towards the proximal region when the connector is introduced inside the tubular body.

Abstract: A disclosed antimicrobial medical device includes a fluid transfer device configured to couple between a patient and a fluid reservoir, a fluid pathway extending through the fluid transfer device, a first electrode coupled to the fluid transfer device, and a second electrode coupled to the fluid transfer device and spaced apart from the first electrode. The first electrode includes a first conductive material and the second electrode includes a second conductive material different from the first conductive material. The second electrode is configured to form a galvanic cell with the first electrode.

Abstract: This application discloses configurations for arranging transducer arrays on a person's head to impose tumor treating fields (TTFields) in the brain at field strengths that are as uniform as possible throughout the entire brain. In some embodiments, L-shaped sets of electrodes are positioned near the right and left ears, each with a horizontal arm above the ear and a vertical arm behind the ear. Optionally, these embodiments may be combined with a second pair of electrodes positioned on top of the head and behind the neck. In other embodiments, one pair of electrodes is positioned above the right ear and on the left/rear portion of the neck; and a second pair of electrodes is positioned above the left ear and on the right/rear portion of the neck. These configurations improve the uniformity of the electric fields imposed throughout the brain, and are particularly useful for preventing and/or treating metastases.

Abstract: This application discloses configurations for arranging transducer arrays on a person's head to impose tumor treating fields (TTFields) in the brain at field strengths that are as uniform as possible throughout the entire brain. In some embodiments, L-shaped sets of electrodes are positioned near the right and left ears, each with a horizontal arm above the ear and a vertical arm behind the ear. Optionally, these embodiments may be combined with a second pair of electrodes positioned on top of the head and behind the neck. In other embodiments, one pair of electrodes is positioned above the right ear and on the left/rear portion of the neck; and a second pair of electrodes is positioned above the left ear and on the right/rear portion of the neck. These configurations improve the uniformity of the electric fields imposed throughout the brain, and are particularly useful for preventing and/or treating metastases.

Abstract: The disclosure provides a self-powered sheet which is configured to absorb and to be applied on a human skin. The self-powered sheet includes a base layer and a plurality of electrically conductive inks. The base layer is configured to absorb the liquid and adapted to be applied on the human skin. The base layer has a contact surface. The electrically conductive inks are disposed on the contact surface of the base layer. Each of the electrically conductive inks has a plurality of first electrodes and a plurality of second electrodes. When each of the first electrodes and each of the second electrodes are soaked in the liquid, an electrical potential difference between one of the plurality of first electrodes and one of the plurality of second electrodes generate a current in the human skin.

Abstract: An exemplary cochlear implant assembly includes an implantable cochlear stimulator (ICS) configured to apply electrical stimulation to a recipient by way of an electrode array. The ICS is housed in a casing that comprises a first surface area configured to serve as a current path to ground for the electrical stimulation and a second surface area. The cochlear implant assembly further includes an encapsulant that includes a conductive portion configured to cover the first surface area of the casing and be in conductive contact with the first surface area such that the conductive portion serves as the ground electrode and a non-conductive portion configured to cover the second surface area of the casing such that the casing is entirely disposed within the conductive and non-conductive portions of the encapsulant. Corresponding methods for manufacturing cochlear implant assemblies are also described.

Abstract: An implantable direct-current electrode assembly (20, 120) has two implantable electrodes (30; 40) and a control circuit (50), to which the first and the second electrodes (30; 40) are electrically connected. The control circuit (50) is designed to establish a potential difference between the two electrodes (30; 40), so that a direct current (55) can flow between the two electrodes (30; 40). One of the electrodes (30) is a coil electrode with a maximum length that is pre-determined by the distance between the tricuspid valve and the end of the right ventricle lying opposite the tricuspid valve and the pulmonary valve. The counter-electrode (40) can be a coil electrode for the coronary sinus, or a plate electrode that can be attached to the exterior of the left ventricle.

Abstract: An electrode assembly for the positioning of an electrode of an implantable medical lead includes a housing and an electrode subassembly. The housing includes a proximal end for connecting to the lead and a distal end. The housing defines a housing lumen extending between the proximal end and the distal end. The housing lumen includes internal screw threads extending along at least a portion of the housing lumen. The electrode subassembly is disposed at least partially within the housing lumen. The electrode subassembly includes a needle electrode and a coupler. The needle electrode is disposed coaxially with the longitudinal axis of the housing lumen. The coupler is disposed at a proximal end of the needle electrode. The coupler includes external screw threads engaged with the internal screw threads of the housing lumen such that rotation of the coupler moves the needle electrode along the longitudinal axis of the housing lumen.

Abstract: A living body stimulation device includes an outputting unit that outputs a stimulation signal to a living body. The stimulation signal is a signal in which a positive pulse group and a negative pulse group appear alternately at predetermined intervals. The positive pulse group is constituted by a plurality of pulses whose potential rises toward the plus-side. The negative pulse group is constituted by a plurality of pulses whose potential falls toward the minus-side.

Abstract: A sensing device for detecting an artificially induced neuromuscular response within a limb of a subject includes a carrier material and a plurality of mechanical sensors. The carrier material is operative to be secured around a portion of the limb, and each of the plurality of mechanical sensors are coupled with the carrier material. Each mechanical sensor is positioned on the carrier material such that it is operative to monitor a mechanical response of a different muscle group of the limb. Each mechanical sensor then generates a respective mechanomyography output signal corresponding to the monitored mechanical response of its adjacent muscle group. These signals may then be communicated outbound from the device via communication circuitry provided on the device.

Abstract: Provided herein are methods and devices useful for inhibiting or treating urological conditions, such as overactive bladder (OAB) symptoms including bladder overactivity, urinary frequency, urinary urgency, urinary incontinence, interstitial cystitis (IC), urinary retention, and pelvic pain; gastrointestinal conditions, such as fecal incontinence, irritable bowel syndrome (IBS), and constipation; and sexual conditions, such as premature ejaculation, erectile disorder, and female sexual arousal disorder by non-invasive transcutaneous electrical stimulation of the foot.

Abstract: One general aspect includes a system to mitigate motion sickness/emesis, the system including: a memory configured to include one or more executable instructions and a processor configured to execute the executable instructions, where the executable instructions enable the processor to: in response to an activation of a motion-equalizing device installed in an interior of a vehicle, provide electric stimulus to a vehicle occupant via the motion-equalizing device, where the electric stimulus is designed to mitigate one or more symptoms of motion sickness and/or emesis for the vehicle occupant.

Abstract: A cochlear implant including a cochlear lead, an antenna, a stimulation processor, and a magnet apparatus, associated with the antenna, including a case and a magnet assembly, having a spine and at least one magnet that is secured to the spine, that is located within the case and is rotatable relative to the case.

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

Abstract: Devices, systems, and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

Abstract: This document provides methods and materials involved in detecting and delivering neurochemical signals, electrophysiological signals, ions, or combinations thereof within a mammal. For example, systems that can include one or more implantable devices containing probes configured to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, ions, or combinations thereof and one or more implantable devices containing electrodes and/or microfluidic delivery components configured to deliver neurochemical signals (e.g., neurotransmitters), electrical signals, ions, or combinations thereof to one or more locations within a mammal are provided.

Abstract: An implantable hearing unit is provided that includes an implantable microphone, a rechargeable power storage device and a speech signal processor. The hearing unit further includes a signal coupling device that is adapted for electrical interconnection to an implantable auditory stimulation device, which is operative to stimulate an auditory component of a patient. Such a stimulation device may include cochlear implants, brain stern stimulation systems, auditory nerve stimulation systems, and middle or inner ear transducer systems. The signal coupling device is operative to provide processed drive signals from the signal processor to the stimulation device as well provide power from the power storage device to operate the stimulation device. In one arrangement, the signal coupling device is a wireless coupling between first and second coils. In such an arrangement, the hearing unit may be utilized with an existing implanted stimulation device to make that device a fully implanted hearing system.

Abstract: A wearable cardioverter defibrillator (WCD) comprises a support structure to be worn by a patient, an energy storage module to store an electrical charge, a discharge circuit coupled to the energy storage module, a measurement circuit, a user interface that includes a speaker, and a processor.

Abstract: A method and medical device for detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector sensing a first interval of the cardiac signal during a predetermined time period and a second sensing vector simultaneously sensing a second interval of the cardiac signal during the predetermined time period, identifying each of the first interval and the second interval as being one of shockable and not shockable in response to first processing of the first interval and the second interval and in response to second processing of one or both of the first interval and the second interval, the second processing being different from the first processing, and determining whether to deliver therapy for the cardiac event in response to identifying each of the first interval and the second interval as being one of shockable and not shockable in response to both the first processing and the second processing of the first interval and the second interval.

Abstract: An extra-cardiovascular implantable cardioverter defibrillator senses R-waves from a first cardiac electrical signal by a first sensing channel and stores a time segment of a second cardiac electrical signal in response to each sensed R-wave. The ICD determines intervals between successively sensed R-waves and, in response to at least a predetermined number of the intervals being less than a tachyarrhythmia detection interval, analyzes at least a portion of the time segment of the second cardiac electrical signal corresponding to a most recent one of the sensed R-waves to confirm the most recent one of the R-waves. The ICD updates an unconfirmed beat count in response to the most recent one of the R-waves not being confirmed and withholds detection of a tachyarrhythmia episode in response to the unconfirmed beat count being equal to or greater than a rejection threshold.

Abstract: A remote communications system for providing enhanced communication with cardiac devices includes a wearable defibrillator disposed on a torso of a patient and a remote device. The wearable defibrillator includes one or more buttons configured to be actuated by the patient to indicate that the patient is conscious, a speaker configured to communicate information to the patient, a wearable defibrillator transceiver configured to transmit the information, and a processor in communication with the speaker and the wearable defibrillator transceiver. The remote device includes a wireless transceiver for bi-directional communication configured to receive the information from the wearable defibrillator, at least one of a touch screen and a speaker, and a processor configured to cause the remote device to provide via the at least one of the touch screen and the speaker at least one of an alarm, voice message, and prompt based on the received information.

Abstract: An improvement on a method and device of the first wearable device that increases muscle strength using a holding device containing nutrients. This invention is detailed in U.S. Pat. Nos. 8,617,590, 9,636,310, 9,510,988. With the addition of a light source module and/or a vibrating module and/or a magnetic module to this holding device, it has been found that the resulting device has a surprising and unexpected synergistic effect on muscle strength. This phenomenal increase in muscle strength translates into improved athletic performance. The resulting holding device may be in the form of a belt, locket, headband, wrist band, ankle band, pedal device, helmet, or gloves.

Abstract: Transcranial magnetic stimulation may be delivered to a subject based on a treatment plan. This treatment plan is generated using connectivity-image guidance to identify one or more optimal locations to stimulate based on network properties. In turn, a cortical column cosine principle may be applied to identify one or more particular subject locations at which to deliver TMS to the subject to the optimal locations.