Abstract: A method and system are provided for continuous monitoring perfusion of an organ or extremity, and for early detection of progressive partial occlusion of arterial blood supply or venous drainage of tissue. The method and system measure a delay in wave propagation of a blood perfusion wave, which is associated with flow of blood through a blood vessel. The delay is correlated to an amount of obstruction in the blood vessel.

Abstract: A time-resolved measurement of blood pressure, arterial elasticity, pulse wave, pulse wave transit time and pulse wave velocity, a cardiac output, and/or changes in cardiac output of a human or animal body, using a pressure sensor unit while being pressed against the skin. The unit is an air and/or gas pressure sensor, and is configured to change at least one electrical conductance and/or resistance when subjected to pressure. The unit has at least two conductor trace arrays, particularly conductor trace networks, and a functional polymer that is compressed when subjected to pressure, and produces and/or alters contact between the conductor trace arrays. Alternatively, the unit has at least two conductive layers with a gap therebetween, and is configured such that the gap becomes compressed when subjected to pressure, and/or such that the capacitance of the assembly composed of the two conductive layers is changed as a result.

Abstract: The present invention relates to a wearable device for obtaining signals from a subject for use in the monitoring of pulse-related information of the subject. To enable the use of such a device in the monitoring of pulse-related information of the subject, which provides for unobtrusive, reproducible, easy to use, and simple measurements, the device comprises a device body (20), a PPG signal sensing unit (21) for acquiring a first photoplethysmography, PPG, signal from a first body location of the subject's body, and an imaging unit (22) for acquiring a sequence of images from a second body location of the subject's body different from the first body location, said sequence of images being configured for deriving a second PPG signal for the second body location of the subject's body. Said PPG signal sensing unit and said imaging unit are mounted in or at the device body and are configured to simultaneously acquire the first PPG signal and the sequence of images.

Abstract: Modular personal networks (MPNs) are disclosed that include multiple devices that may be worn, carried, or used in close proximity to a user. The devices communicate wirelessly. Devices include security circuitry that prevents them from being used in a different MPN once the user has configured them. Devices not designed for use within an MPN can be included in the network using a bridge device. Devices can be integrated into items of jewelry, such as earrings, rings, pendants, and bracelets. One item of jewelry, such as a bracelet, can support multiple replaceable modules with variable functions. Functions of the MPN can include communications, entertainment, medical monitoring, sports monitoring, personal organization, and games. Multiple users each with his or her own MPN can use them to collaborate in creation of music. An MPN can be used for mobile recognition and logging of wildlife.

Abstract: Stacked strain gauge sensors with increased electrical resistance are provided. In one aspect, a method of forming a stacked strain gauge sensor includes: forming multiple sensor layers, wherein the sensor layers include strain gauge sensor wires on substrates; forming holes in the substrates; stacking the sensor layers, one on top of another, to form a stack with the holes aligned in one or more locations forming through holes in the stack; and forming interconnects in the holes in one or more other locations interconnecting the strain gauges sensor wires between adjacent sensor layers to form a stacked strain gauge sensor. A stacked strain gauge sensor and method of use thereof are also provided.

Abstract: An acoustic sensor attached to a medical patient can non-invasively detect acoustic vibrations indicative of physiological parameters of the medical patient and produce an acoustic signal corresponding to the acoustic vibrations. The acoustic signal can be integrated one or more times with respect to time, and a physiological monitoring system can determine pulse or respiration parameters based on the integrated acoustic signal. The physiological monitoring system can, for instance, estimate a pulse rate according to pulses in the integrated acoustic signal and a respiration rate according to a modulation of the integrated acoustic signal, among other parameters. Further, the physiological monitoring system can compare the integrated acoustic signal or parameters determined based on the integrated acoustic signal with other signals or parameters to activate alarms.

Abstract: There is described are electroencephalography (EEG) device. The EEG device comprises one or more inputs for connecting via electrodes to a subject, and one or more DC/AC EEG amplifiers for amplifying electric potential signals from a subject. Each DC/AC EEG amplifier comprises a preamplifier connected to the one or more inputs and configured to amplify a signal received at the one or more inputs, the preamplifier having a differential gain set so as to have a common mode rejection ratio (CMRR) of at least 100 dB. Each DC/AC EEG amplifier further comprises an amplifier circuit connected to the preamplifier and configured to further amplify the signal, and, based thereon, output an output signal comprising a DC component having a frequency of less than 0.02 Hz.

Abstract: A method of processing a signal representing a physiological rhythm of a subject, the method comprising the steps of receiving the signal from the subject, filtering the signal with a band pass filter, extracting an analysis window from the filtered signal, performing a plurality of interval length estimation methods on the filtered signal in the analysis window, summing the outputs of the plurality of interval length estimation methods, and determining an interval length from the sum of the outputs of the plurality of interval length estimation methods.

Abstract: Disclosed are various examples and embodiments of a cardiac mapping catheter configured for electrophysiological (EP) mapping and suitable for intravascular insertion in a patient's heart, and methods of making same. The cardiac mapping catheter comprises a plurality support arms having electrodes disposed thereon. Various configurations of the cardiac mapping catheter are described and disclosed which provide improved spatial resolution and sensing of EP signals acquired from inside a patient's heart.

Abstract: An electronic device for long-term adhesion to a mammal includes a housing with an electronic component. The electronic device may include a first wing and a second wing, each being integrally formed with the housing. An electrode is positioned on a bottom surface of each of the wings, the electrodes electrically connected to the electronic component. An adhesive layer is provided for adhesion to a surface of the mammal. The adhesive layer may cover a portion of the bottom surfaces of the wings but generally does not cover the electrode or a bottom surface of the housing. A method of applying an electronic device to a mammal includes removing first and second adhesive covers from first and second wings of the electronic device to expose an electrode and an adhesive coated on a bottom surface of each wing.

Abstract: An electromyography (EMG) sensor for a wearable device, such as a prosthetic device attachable to a residual limb, includes a flexible substrate comprising an elongated portion and an electrode portion. At least two electrodes are disposed at a surface of the electrode portion of the flexible substrate, and leads from the at least two electrodes extend through the elongated portion of the flexible substrate.

Abstract: A medical device that is essentially a box with separate chambers to be used in conjunction with a typical 5 lead or 12 lead EKG/ECG wire set to prevent the EKG/ECG wires from tangling by keeping the wires separated and when used as intended will aid in rapid easy proper placement of the lead wires on the human body to expedite diagnostic results.

Abstract: A medical device system includes a cardioverter-defibrillator for detecting and treating ventricular tachycardia (VT). The medical device system includes a sensing module for sensing a cardiac signal from available cardiac signal sensing vectors. A control module generates morphology templates of the cardiac signals for multiple patient postures for each of the available sensing vectors and determines a set of posture-independent template features. An unknown cardiac rhythm is classified in response to comparing features of a cardiac signal received during the unknown rhythm to the set of posture-independent features.

Abstract: An ultra-low field pre-pulse Magnetic Resonance Imaging (PMRI) system for a head includes RF coils defining a bore for head access, a pre-pulse coil outside the RF coils, and a coil assembly including a main magnetic field coil and gradient coils outside the pre-pulse coil. The PMRI system includes a first cylindrical shield concentric with the RF coils and made from conductive materials. The first cylindrical shield partially encloses the RF coils and inside the pre-pulse coil for shielding the RF coils from environmental electromagnetic disturbances.

Abstract: A micro impulse radar (MIR) system includes a first sensor, a second sensor, and a control circuit. The first sensor includes a micro impulse radar (MIR) sensor configured to receive a plurality of radar returns corresponding to an MIR radar signal transmitted towards a subject. The second sensor is configured to detect sensor data regarding the subject. The control circuit is configured to calculate a physiological parameter of the subject based on the plurality of radar returns and the sensor data.

Abstract: A micro impulse radar (MIR) system includes an MIR transceiver circuit configured to transmit, towards a subject, at least one transmitted radar signal, and receive at least one radar return signal. The system includes a control circuit configured to generate a control signal defining a radar signal parameter of the at least one transmitted radar signal, provide the control signal to the MIR transceiver circuit to cause the MIR transceiver circuit to transmit the at least one transmitted signal based on the radar signal parameter, and determine, based on the at least one radar return signal, a physiological parameter of the subject.

Abstract: Systems, methods, and devices for capturing and assessing bioelectric measurements. A method includes receiving a skin resistance measurement for a skin site of a user from an electrodermal sensor and determining a standard skin conductivity value. The method includes calculating a compensation factor for the user based at least in part on the skin resistance measurement and the standard skin conductivity value.

Abstract: A system for determining characteristics of a specific region within an inhomogeneous dielectric specimen by guiding propagation of electric fields through the inhomogeneous dielectric specimen is provided herein. Various embodiments include at least one source of electromagnetic energy for generating electromagnetic waveforms, the electromagnetic waveforms comprising electric fields propagating along a prescribed path that defines a series of spatial regions through which the electric fields propagate. In some embodiments the prescribed path includes electric field modulating elements that determine a rate of electric field propagation along the prescribed path. Some embodiments include a plurality of conductors for guiding the electric field propagation through an inhomogeneous dielectric specimen in the prescribed path, the electric fields spanning between two or more of the plurality of conductors as the electric fields propagate along the prescribed path.

Abstract: The disclosed technology is directed to an endoscopic system comprises an endoscope having a shank and a photodetector engaged with one another and having an optical axis in a direction transverse to the shank. A display device for displaying an image acquired through the photodetector. A first probe is disposed in the endoscope on or around the optical axis at a position off the shank. A second probe is disposed in the endoscope at or near a position where the shank and the optical axis intersect with each other. A sensor for detecting the position of the first probe and the position of the second probe and a controller. The controller is configured to establish a first reference direction in an actual space. To acquire a direction from the second probe toward the first probe and to perform a process for indicating the first reference direction to a user.

Abstract: One or more devices, systems, methods and storage mediums for performing medical procedure (e.g., needle guidance, ablation, biopsy, etc.) planning and/or performance, and/or for performing registration using at least one mask, are provided. Examples of applications for such devices, systems, methods and storage mediums include imaging, evaluating and diagnosing biological objects, such as, but not limited to, lesions and tumors, and such devices, systems, methods and storage mediums may be used for radiotherapy applications (e.g., to determine whether to place seed(s) for radiotherapy). The devices, systems, methods and storage mediums provide improved registration results by utilizing at least one mask to suppress one or more artifacts or objects (which may or may not include, but is not limited to, at least one medical instrument or tool) in an image including a portion of the medical guidance device and/or to enhance a region or target of interest in the image.

Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can be used in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.

Abstract: A method and system for determining an amount of risk an air pollutant poses to a subject. A risk level is calculated by determining a dosage of the air pollutant, received by the subject over a predetermined period of time, and obtaining historic information about historic dosages of the air pollutant. The risk level is then calculated using the dosage and the historic information to thereby determine a risk level associated with the accumulated deposition of the air pollutant in the portion of the subject's respiratory tract.

Abstract: A system including a first sampling portion configured to sample inhalation gas made up of a first gaseous mixture, a second sampling portion configured to sample exhalation gas made up of a second gaseous mixture, a gas analyzer configured to measure gas concentrations, a switching valve that controls flow of the sampled inhalation gas and the sampled exhalation gas to the gas analyzer so as to alternately measure concentration of gaseous components within the first and second gaseous mixtures, a humidity control system that maintains humidity within the first and second gaseous mixtures to a predetermined humidity level, and a calculation section configured to calculate concentration differences of the gaseous components between the first and second gaseous mixtures.

Abstract: An electronic device includes a measurement unit configured to measure a contour of a body by the electronic device being moved along a surface of the body and a controller configured to generate a three-dimensional image of the body based on the contour. The controller is configured to generate the three-dimensional image by lining up a plurality of first contours measured along a first direction.

Abstract: The invention provides a seismocardiograph system, which includes an accelerometer, adapted to obtain accelerometer data from user, and a bandpass filter, adapted to filter the accelerometer data. The system further includes an envelope filter, adapted to suppress S2 peaks in the band pass filtered accelerometer data, wherein the envelope filter comprises: a low-pass filter; and a comb filter, wherein the delay of the comb filter is tuned to a left ventricle ejection time (LVET).

Abstract: An information processing device includes a computation unit that minimizes a difference between an observed displacement and an estimated displacement of an elastic body so as to find an optimal solution that determines a magnitude of an external force that acts upon an observed manipulation point and a distribution of an elastic modulus in a three-dimensional model of the elastic body, wherein the observed displacement is that acquired from an observed part of the elastic body in an image, and the estimated displacement is that acquired from a region of the three-dimensional model of the elastic body which has been captured, the region corresponding to the observed part.

Abstract: A location detection system identifies the locations of medical devices such as patient support apparatuses and/or patient care devices within a medical facility. The devices communicate via a wired connection to one or more medical facility systems (e.g. nurse call system, computer network, etc.), and/or via a wireless connection to such systems. The location detection system automatically determines location information of the devices and communicates the location information so that the recipient of any outgoing alerts and/or other information sent from the devices is apprised of the location of the particular device sending the alert or other information. Caregivers are thereby able to respond to the correct location of an alert, and software systems such as EMR systems, admission discharge and transfer (ADT) systems, etc. are able to correlate transmitted device data with the location and/or patient assigned to that location.

Abstract: Systems, devices, methods, and software for measuring and quantifying a limb movement are disclosed. An electromagnetic field generator generates an electromagnetic field; a plurality of electromagnetic sensors, positionable inside of the electromagnetic field and at different locations on a limb, generate position and orientation data; an electromagnetic stylus positionable inside of the electromagnetic field generates position and orientation data when activated; a processor coupled to the plurality of electromagnetic sensors and the stylus receives the data generated by the sensors and the stylus and calculates an angular movement of the limb and translation of an appendage coupled to a joint; and a display coupled to the processor displays at least one of the calculated angular movement and translation.

Abstract: Examples of systems and methods described herein may estimate the bilirubin level of an adult subject based on image data associated with a portion of the eye of the subject (e.g., a color of the sclera). Accessories are described which may facilitate bilirubin estimation, including sensor shields and calibration frames.

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

Abstract: An apparatus for estimating an analyte concentration includes a spectrum acquisition device configured to obtain a plurality of in vivo spectra for training which are measured during a first interval, and obtain an in vivo spectrum for analyte concentration estimation which is measured during a second interval, and a processor configured to generate a plurality of candidate concentration estimation models by varying a number of principal components based on the plurality of in vivo spectra for training, obtain a plurality of residual vectors corresponding to the plurality of in vivo spectra for training by using the plurality of candidate concentration estimation models, select a candidate concentration estimation model, from among the plurality of candidate concentration estimation models, based on the plurality of residual vectors, and estimate the analyte concentration by using the selected candidate concentration estimation model and the in vivo spectrum for analyte concentration estimation.

Abstract: Methods and apparatus for acquiring data associated with a monitored analyte level, determining a glucose level based at least in part on the acquired data associated with the monitored analyte level, manipulating a data set based on a processing mode following the glucose level determination, where the processing mode includes one of a data set transmission and output display, a data set storing and output display without transmission, or a data set transmission and data set storing without output display are provided.

Abstract: Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.

Abstract: A funnel-shaped extension attachment is provided for a blood collection device. The attachment provides a larger area for collecting a fingertip blood sample from a patient than the collection device itself would otherwise provide. The funnel is preferably easily removable from the collection device after the blood sample is taken. Optional trenches running down one or more corners of the attachment may be used to encourage pulling blood drops from the finger tip through capillary action. A tube may also provide another location to encourage pulling blood drops from the finger tip through capillary action. The funnel attachment may be mated with the collection device at a point of manufacture, or separately shipped and installed over the collection device at a point of use.

Abstract: A blood sample collection device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect and optionally process the sample. A sample event detection circuit triggers a recording of a time when the sample was taken. The sample event detection circuit may determine when the housing is closed, or may detect the presence of blood in or near the sample port. The electronics may optionally record environmental conditions such as temperature or humidity, etc. at the time the sample is taken. The recorded data may then be used to enhance the value or accuracy of lab test, or for other purposes, such as inventory management.

Abstract: The present disclosure relates generally to a system and method for detecting or indicating a state of impairment of a test subject or user due to drugs or alcohol, and more particularly to a method, system and application or software program configured to creating a virtual-reality (“VR”) environment that implements drug and alcohol impairment tests, and which utilizes eye tracking technology to detect or indicate impairment.

Abstract: A system includes a display device, a user interface, a memory, and a control system. The memory contains machine readable medium including machine executable code storing instructions for performing a method. The control system is coupled to the memory, and includes one or more processors. The control system is configured to execute the machine executable code to cause the control system to display, on the display device, a series of questions from mental health questionnaires. The series of questions includes text and answers for each question. From the user interface, a selection of answers of each of the displayed series of questions is received from a patient. Using a Bayesian Decision List, the received selection of answers is processed to output an indication of mental health of the patient. The indication of mental health identifies a kappa opioid receptor antagonist to which the patient would likely be a higher responder.

Abstract: Methods and systems, which are computerized, monitor the attention level of a subject, by obtaining at least one set of biomarkers from a subject during a time period, and, calculate, from asymmetries between the biomarkers of the at least one set of obtained biomarkers, a score of attention of the subject during the time period.

Abstract: Disclosed is a nursing machine that includes a wearable working head and a urine detection circuit. The urine detection circuit includes at least two first urine sensors and at least two second urine sensors that are arranged on the working head. In response to more than one first urine sensor each outputting a liquid detected signal or in response to more than one second urine sensor each outputting the liquid detected signal, the urine detection circuit is configured to output a urine signal. In response to only one first urine sensor or only one second urine sensor outputting the liquid detected signal or in response to only one first urine sensor and only one second urine sensor each outputting the liquid detected signal, the urine detection circuit doesn't output the urine signal.

Abstract: The application generally relates to olfaction as a biomarker, more particularly as a prognostic biomarker or biological predictor, of neurosensory disease or disorder and/or of neurocognitive disease or disorder, in subjects whose nervous system has been infected by an infectious agent, such as by a neurotropic virus, bacterium, protozoan parasite, fungus or prion, more particularly by a neurotropic virus.

Abstract: The present disclosure relates to noninvasive methods for detecting liver fibrosis. Disclosed herein are noninvasive liver fibrosis detection methods that use Doppler Ultrasound devices and a physics-based machine learning method. Further disclosed herein are methods for detecting liver fibrosis in a subject by detecting and measuring the presence of a shift in the frequency of blood flow in the hepatic vein as compared to the frequency of blood flow in the portal vein.

Abstract: The Breast Sense Feeding Monitor provides real-time measurement of breastfeeding metrics including milk volume and infant suck and swallow characteristics over multiple feedings. The wearable design lends itself to versions suitable for both home and in-clinic use.

Abstract: Methods and system are described for multi-modal, multi-parametric, non-invasive, and real-time assessment of cervical tissue through a multi-modal probe device for use within a vaginal canal and an associated imaging system to assess a risk of preterm delivery of an expectant mother. The multi-modal system may include ultrasound (US) imaging, viscoelastic (VE) imaging, and/or photoacoustic (PA) imaging of the cervical issue to determine cervical biomarker information indicative of parameters including, but not limited to, a collagen to water ratio such that a more water dominant ratio is indicative of a risk of preterm delivery.

Abstract: A diagnostic system is provided for classifying a soft tissue condition within a region of interest of a subject. The diagnostic system comprises a spectrometer system configured to irradiate a soft tissue within a region of interest of a subject, and configured to generate spectral data by acquiring at least a portion of the reflected or emitted light from the region of interest. The diagnostic system further comprises a thermal detection system including at least one thermal sensor that is configured to acquire thermal detection data from the region of interest. A computer system is then used to build a classification model based on input thermal detection and spectral data. The classification model is then applied to an unknown soft tissue condition to classify the condition (e.g., classifying cellulitis from pseudocellulitis).

Abstract: Provided is a spectrum processing apparatus for removing noise, caused by a change in temperature, from a spectrum. The spectrum processing apparatus includes: a temperature modulator configured to perform modulation of a temperature of an object; a spectrometer configured to obtain a first spectrum based on the temperature of the object that is changed by the modulation; and a spectrum processor configured to extract a temperature change vector based on the first spectrum, and to correct a second spectrum based on the extracted temperature change vector.

Abstract: Methods for assessing a skin surface of a patient and associated systems and devices are described herein. A method configured in accordance with embodiments of the present technology can include, for example, receiving a three-dimensional data set representative of the patient's skin surface and determining a boundary of a feature of the patient's skin in the three-dimensional data set. The method can further include determining, with a processor, a three-dimensional surface area of the feature within the boundary. In some embodiments, the method can also include identifying a plurality of sub-regions within the boundary and identifying one or more tissue types in each sub-region.

Abstract: A method for standardizing diagnosis of medical conditions. The method includes defining first order data to collect for a patient having at least one symptom and providing a computing system for assigning a diagnosis of a medical condition from possible diagnoses corresponding to possible medical conditions. The computing system includes a memory system storing analysis modules that include tissue-pathology characteristics databases for the possible medical conditions corresponding to the possible diagnoses. The method includes receiving in the memory system the first order data for the patient, comparing with the computing system the first order data to the tissue-pathology characteristics databases, and assigning fit scores for each of the possible diagnoses based on the comparison between the first order data and the tissue-pathology characteristics databases. The method includes assigning the diagnosis of the medical condition for the patient based on the fit scores.

Abstract: The present invention provides a human-computer interactive rehabilitation system, which can automatically calculate rehabilitation strength suitable for the patient, so that it is not necessary to manually evaluate and adjust the parameter settings in human-computer interactive rehabilitation system when different patients use it. At the same time, the human-machine interactive rehabilitation system and the hospital end can track the rehabilitation status and intervene through the data platform at any time. The platform establishes a cloud community feedback and encouragement mechanism, and immediately transmits the rehabilitation results to the designated barriers of the patients, provides patient encouragement feedback, and strengthens the community interaction and linkage in the medical relationship.

Abstract: A method is disclosed for controlling one or more appliances in a user environment, the one or more appliances in operation capable of causing environmental stimuli disruptive to a user's sleep. The method comprises receiving from one or more sensors data indicative of a sleep state of the user; analysing the received data to determine one or more control actions for controlling the one or more appliances to reduce sleep disruption due to the environmental stimuli caused by the appliances; and controlling the one or more appliances in dependence on the determined control actions. The method may involve determining, based on sleep state data for a first sleep period, an appliance control schedule for a second, later, time period.

Abstract: There is provided a method and apparatus comprising a processor to provide guidance for placement of a wearable device. At least one image of the body of a subject is acquired from one or more cameras (502). The at least one acquired image is analysed to recognise body parts of the subject and to identify a body part of the subject at which to place the wearable device (504). Guidance to place the wearable device at the identified body part of the subject is provided (506).