Abstract: The invention relates to an OCT system comprising an OCT light source, an OCT evaluation unit, a first OCT light guide, a second OCT light guide and a changeover module. The light from the OCT light source passes through the changeover module. In a first state of the changeover module, the OCT light is passed to an entry end of the first OCT light guide. In a second state of the changeover module, the OCT light is passed to an entry end of the second OCT light guide. A scanning device assigned to the first OCT light guide is arranged between the changeover module and the object plane. The OCT system according to the invention can be used in a flexible manner.

Abstract: An apparatus for acquiring intraoral images of a subject has an OCT imaging apparatus having an OCT light source, a scanner that conveys OCT light toward the subject and returned from the subject, and an interferometer having a reference arm and a sample arm. A reflectance imaging apparatus has a visible light source directed toward the subject and an image sensor that forms a reflectance image from returned light. Processing and control logic are configured to process and combine the returned reflectance image to the OCT measured data. A display shows the combined reflectance image and OCT measured data.

Abstract: An exemplary optical apparatus has an OCT imaging apparatus with a first light source for low coherence light of wavelengths above a threshold wavelength and a signal detector that obtains an interference signal between low coherence light from the sample and low coherence light reflected from a reference. A surface contour imaging apparatus has a second light source that emits one or more wavelengths of surface illumination below the threshold wavelength, a camera to acquire images from illumination reflected from the sample. The exemplary optical apparatus and/or exemplary methods for using the same can provide reduced errors in generating a dental 3D surface mesh.

Abstract: An illumination device and a using method of the illumination device are provided. The illumination device includes a housing, an illuminator fixed to the housing and a detector installed on the housing, and the detector is configured to detect vital signs of an object to be detected.

Abstract: A system and method for mapping metabolic data of a heart. The system has a light source directing light onto the heart, one or more lenses for focusing an image of the heart, and a fluorescent detector receiving the focused image and generating transients and/or waves to map metabolic cardiac data.

Abstract: An image diagnosis catheter includes a rotatable drive shaft, a sheath into which the drive shaft is inserted, a housing provided at a distal end of the drive shaft and accommodating an ultrasound transmitter and receiver and an optical transmitter and receiver, and a positioning member fixed to the housing and fixing a relative position of the optical transmitter and receiver with respect to the ultrasound transmitter and receiver.

Abstract: A treatment system is provided and includes a treatment probe configured to perform treatment on a subject portion by irradiating the subject portion in a subject with light, an acoustic wave reception unit configured to receive an acoustic wave generated by irradiating the subject with light and to output a reception signal, an acquisition unit configured to acquire quantitative information about the subject portion based on the reception signal, and a display control unit configured to perform control to display the quantitative information about the subject portion.

Abstract: The present invention relates to a probe and a system for optoacoustic imaging of an object as well as a method for controlling such a probe. An irradiation unit of the probe is configured to emit electromagnetic radiation and to irradiate the object with the electromagnetic radiation, and a detection unit of the probe is configured to detect primary acoustic waves emitted by the object in response to irradiating the object with the electromagnetic radiation.

Abstract: The present invention discloses a method for guiding and releasing energy based on a three-dimensional skin temperature topographic map, and also relates to a corresponding device for guiding and releasing energy. The device for guiding and releasing energy performs dynamic closed-loop control on a temperature sensor and an interventional energy release unit, and eventually controls a temperature value of skin tissue to be within an optimal temperature range to achieve dynamic balance between interventional energy therapy and dynamic monitoring and diagnosis. The three-dimensional skin temperature topographic map is displayed according to spatial location data and real-time temperature data, so that an operator is provided with intuitive and clear operation instructions.

Abstract: In some examples, a device includes sensing circuitry configured to receive one or more signals from a patient and processing circuitry configured to determine a plurality of autoregulation state values associated with a plurality of blood pressure values based on the one or more signals. The processing circuitry is further configured to determine that a first autoregulation state value of the plurality of autoregulation state values is anomalous based on other autoregulation state values of the plurality of autoregulation state values. The processing circuitry is also configured to modify the first autoregulation state value in response to determining that the first autoregulation state value is anomalous and determine an autoregulation status of the patient based on the plurality of autoregulation state values including the modified first autoregulation state value.

Abstract: Provided are apparatuses and methods for non-invasively measuring a blood pressure of a mammal subject. The apparatus includes a first sensor system and a second sensor system time-synchronized to each other and spatially separated by a pulse arrival distance L, and a microcontroller unit (MCU). The first and second sensor systems are respectively attached to first and second positions of the mammal subject for detecting first and second signals. The second position is more distal or proximal to a heart of the mammal subject than the first position. The MCU processes the output signals to determine a pulse arrival time (PAT) as a time delay ?t between detections of the first and second signals, and determines a pulse wave velocity (PWV) based on the PAT and L, where PWV = L ? ? ? t . Then the MCU determines the blood pressure P from the PWV, where P is a parabolic function of the PWV.

Abstract: [Subject] Non-invasive method for estimating blood pressure without a cuff and a device for the blood pressure estimation [Resolution means] Systolic blood pressure (EBP) is estimated according to EBP=?1·P1+?2·P2+?0 (?1, ?2, and ?0 are coefficients) where parameter P1, which is related to pulse transit time (PTT), and parameter P2, which is related to stroke volume based on pulse waves, are variables.

Abstract: Embodiments for protecting low-pressure blood pressure sensors in high-pressure fluid flow applications by equalizing pressure on both sides of a pressure sensor's diaphragm during high pressure are disclosed. A sensor protection device may include a pressure sensor assembly, a housing, and a plunger assembly. During low pressure, fluid in the primary flow path can flow through the housing, transferring its pressure to a first side of the diaphragm; the plunger assembly can prevent fluid flow into a secondary flow path in the housing, transferring atmospheric pressure to a second side of the diaphragm. During high pressure, fluid can still flow through the primary flow path, and the plunger assembly may now allow fluid flow into the secondary flow path, transferring pressure from the same fluid to the second side of the diaphragm to equal pressure across the diaphragm. The plunger assembly may automatically transition between low- and high-pressure configurations.

Abstract: A biometric authentication system and method are provided that are based on PPG signals acquired using non-invasive methods, such as pulse oximeter, for example. Compared to the other biometric authentication approaches, PPG signals are relatively easy to acquire, relatively difficult to duplicate, and can be adaptively updated, which are qualities that make them well suited for biometric authentication. However, PPG signals are often corrupted by motion artifacts (MAs) due to the unique measurement technique, i.e., placement of a sensor close to the skin. The system and method employ an MA removal algorithm to remove or mitigate MAs to provide a PPG-based biometric authentication solution that is robust and that can be implemented relatively easily and cost effectively.

Abstract: A system for monitoring includes: multiple EEG sensors spatially positioned on a layer of tissue for capturing EEG signals of a patient; multiple amplifiers coupled with the EEG sensors for amplifying the captured signals; and a low frequency oscillator for generating a synchronizing signal which is distributed to the amplifiers for synchronizing the digitization of the captured signals; wherein each amplifier includes: a voltage controlled oscillator for an adjustable frequency reference; an analog to digital converter for converting the amplified signal to a digital value; and a microcontroller for controlling the frequency of the voltage controlled oscillator and operation of the analog to digital converter by using the synchronizing signal.

Abstract: Devices and methods for dynamically controlling sensitivity associated with detecting R-waves while maintaining the fixed detection threshold are described herein. One such method includes sensing an analog signal indicative of cardiac electrical activity, converting the analog signal indicative of cardiac electrical activity to a digital signal indicative of cardiac electrical activity, and detecting R-waves by comparing the digital signal indicative of cardiac electrical activity to a fixed detection threshold to thereby detect threshold crossings that corresponds to R-waves. The method further includes selectively adjusting a gain applied to the digital signal indicative of cardiac electrical activity to thereby selectively adjust a sensitivity associated with the detecting R-waves, while maintaining the fixed detection threshold.

Abstract: A portable apparatus and a method of changing a content screen of the portable apparatus are provided. The portable apparatus includes changing a displayed content in response to an increase in a visual fatigue and a method of changing a content screen of the portable apparatus. Some of disclosed various embodiments provide a portable apparatus that calculates a visual fatigue by using user electroencephalogram (EEG) information received from a wearable apparatus and changing a displayed content into another content in response to an increase in the calculated visual fatigue, and a method of changing a content screen of the portable apparatus.

Abstract: Provided is a biological information estimation device including: a transmission unit 12 and a transmission antenna 13 for emitting radio waves to the heart; a receiving antenna 14 and a receiving unit 15 for receiving either the radio waves which have passed through the heart or the radio waves which have been reflected by the heart; and an estimation unit 11 for estimating the volume of blood contained in the heart and the degree of change in the volume, on the basis of the amplitude or phase of the radio waves received by the receiving unit 15 and the specific absorbed fractions for the heart.

Abstract: Various embodiments disclosed relate to a resonator system that can be used to monitor status of tissue. A passive resonant sensor having an inductive element and a capacitive element can be implemented in a patch format and attached to tissue. The patch and resonant sensor can be structured such that, when contacting the tissue, dielectric of the contacted tissue contributes to capacitance of the resonant sensor to affect a resonant frequency of the resonant sensor. Additional apparatus, systems, and methods can be implemented with variations in a patch-resonant sensor structure.

Abstract: A surgical instrument includes an impedance sensing system for monitoring the position of the tip of the surgical instrument relative to the pericardial space. The surgical instrument consists of a guidewire or needle including a conductive core terminating at a distal tip of the guidewire or needle. The distal tip has a conductive surface exposed to patient tissues and/or fluids. The impedance sensing system includes a first electrode formed by the exposed surface of the guidewire or needle, and at least a second electrode isolated from the conductive core of the guidewire or needle. The second electrode may be formed on an outer surface of the guidewire or needle, or may be a pad electrode applied to the patient skin. The impedance sensing system also includes an impedance analyzer for measuring impedance and phase using one or more frequencies.

Abstract: An implantable sensor for implantation in a vessel, comprising a plurality of electrodes for placement on, in or adjacent a vessel wall, means for providing a drive signal to the electrodes, means for measuring at least one of impedance and capacitance between at least two of the plurality of electrodes, and means for wirelessly communicating data from the sensor and a blood vessel monitoring system comprising same.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for supporting components of an implantable medical device. The apparatuses, systems, and methods may include a first electrode and a second electrode and a scaffold assembly configured to support the first electrode and the second electrode.

Abstract: A method includes transmitting electrical signals between one or more pairs of body-surface electrodes attached to a body of a patient. Electrical potentials resulting from the transmitted electrical signals are acquired by an outer-facing electrode and an inner-facing electrode of a medical probe inserted in an organ of the patient. A proximity of the medical probe to surface tissue of the organ is estimated based on the electrical potentials acquired by the outer-facing electrode. A position of the medical probe within the organ is estimated based on the electrical potentials acquired by the inner-facing electrode.

Abstract: A device for providing a calibration fluid, in particular a nitrogen oxide, for calibrating a respiratory gas analysis device, includes a first interface for connecting a chamber of the device to a measurement path of the respiratory gas analysis device, a first opening for introducing a reactant carrier with a first reactant into the chamber, and a contact element. The contact element is arranged in the chamber relative to the first opening such that when the reactant carrier is introduced, a contact of the contact element with the reactant carrier is facilitated in order to trigger a chemical reaction of the first reactant so as to generate the calibration fluid. The disclosure further relates to a system, a reactant carrier, and a method for providing a calibration fluid for calibrating a respiratory gas analysis device.

Abstract: A spirometer turbine assembly is described, having a housing with a proximal end opening, a distal end opening and an airflow channel therebetween. A first flow director has a first plurality of flow director blades with distal edges that curve in a plane perpendicular to a longitudinal axis of the airflow channel, and a vane is connected to an axel positioned distal to the first flow director. A spirometer turbine assembly having an anti-static material is also described.

Abstract: A portable incentive spirometry monitoring device and method of use. The device connected to the base of an incentive spirometer and is capable of monitoring inspiration within the incentive spirometer. The portable incentive spirometry monitoring device has a user interface for inputting a variety of different parameters, including a desired air volume, as well as attempt thresholds. Results can be stored such that medical personnel can review attempts by a patient to monitor therapeutic use, as well as encouraging patient use. The portable incentive spirometry monitoring device may be reused with different incentive spirometers without the need for extensive sterilization.

Abstract: A three-dimensional tumor ruler and holder and methods of use thereof are provided. One embodiment provides a three-dimensional tumor ruler to simultaneously measure the length, width, and height of a tumor when positioned on or near the tumor. The tumor measurements can then be used to calculate tumor volume. Tumor volume can be used to accurately determine for example the dose of a drug or radiation to administer to a subject. In another embodiment, the tumor ruler can be used to position the tumor during administration of a drug or radiation therapy to maximize exposure of the tumor to the therapy.

Abstract: A system and a method for a healthcare provider to easily, accurately and efficiently provide a diagnostic hearing assessment, for their patients, in a way that accurately detects hearing loss and provides recommendations for seeking further assistance from remotely-located ear specialists is provided.

Abstract: An apparatus for estimating a biological component may include: a spectrometer configured to measure a background spectrum from an object; and a processor configured to generate a virtual spectrum as training data by combining the background spectrum with a virtual biological component signal including noise, and generate a prediction model for estimating the biological component based on the training data.

Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Abstract: Methods and devices to detect analyte in body fluid are provided. Embodiments include positioning an analyte sensor in fluid contact with an analyte, detecting an attenuation in a signal from an analyte sensor after positioning during a predetermined time period, categorizing the detected attenuation in the analyte sensor signal based, at least in part, on one or more characteristics of the signal, performing signal processing to generate a reportable data associated with the detected analyte sensor signal during the predetermined time period, managing if and when to request additional reference signal measurements, and managing if and when to temporarily not display results.

Abstract: Systems, devices, and methods for monitoring and assessing blood glucose level in a patient are discussed. An exemplary system receives physiologic information from a patient using an ambulatory medical device. The physiologic information is correlated to, and different from, a direct glucose level measurement. The system determines a glucose index indicative of an abnormal blood glucose level using the received physiologic information by the two or more physiologic sensors. The system may use the glucose index to initiate or adjust a therapy, or to trigger a glucose sensor, separate from the two or more physiologic sensors, to directly measure blood glucose concentration.

Abstract: A blood detection method and a blood detection device are disclosed. When a count number of platelet in a blood sample is less than a predetermined value, a detection solution of the blood sample is prepared. A cell statistical amount of the detection solution of the blood sample is increased to obtain the platelet detection result. The cell statistics amount of the detection solution of the blood sample may be increased in an impedance detection area to perform PLT-I detection, or in an RET detection area; or performing both of RET detection and PLT-O detection simultaneously. Thus, the accuracy of platelet detection can be improved when the number of platelets in the blood sample is low.

Abstract: A device includes an optical circuit that obtains a first signal at a first wavelength using light reflected from skin tissue of a patient, wherein the first wavelength has a high absorption coefficient for nitric oxide (NO) in blood flow and a second PPG signal at a second wavelength using light reflected from skin tissue of the patient, wherein the second wavelength has a low absorption coefficient for NO in blood flow. A measurement of a level of NO in blood flow is determined using the first PPG signal and the second PPG signal. A health condition is determined using the measurement of the level of NO, such as hyperglycemia or hypoglycemia.

Abstract: A method of fabricating a wearable device having one or more integrated electronic components, including providing a substrate having an elastomeric material, at least one metal additive, and/or a carbon source additive; forming electrical circuitry within the elastomeric material by structuring one or more electrically conductive traces and plating the one or more electrically conductive traces; and providing the electrical circuitry with a sensor, wherein the sensor is configured to come in direct contact with skin of an individual.

Abstract: A system and method for contactless blood pressure determination. The method includes: receiving a captured image sequence; determining, using a trained hemoglobin concentration (HC) changes machine learning model, bit values from a set of bitplanes in the captured image sequence that represent the HC changes of the subject; determining a blood flow data signal; extracting one or more domain knowledge signals associated with the determination of blood pressure; building a trained blood pressure machine learning model with a blood pressure training set, the blood pressure training set including the blood flow data signal of the one or more predetermined ROIs and the one or more domain knowledge signals; determining, using the blood pressure machine learning model trained with a blood pressure training set, an estimation of blood pressure; and outputting the determination of blood pressure.

Abstract: In an embodiment, the optoelectronic sensor module (1) comprises a first semiconductor transmitter chip (21) for emitting radiation of a first wavelength and a second semiconductor transmitter chip (22) for emitting radiation of a second wavelength. A semiconductor detector chip (3) is provided for the detection of the radiation. The chips (21, 22, 3) are located in a common plane and are mechanically connected to one another by a potting body (4) which is opaque to the radiations, the potting body (4) extending directly onto side faces of the chips (21, 22, 3). A distance between the chips (21, 22, 3) is less than or equal to twice the average diagonal length of the chips (21, 22, 3). The sensor module (1) is designed to be attached to a part of a body (7) to be examined.

Abstract: Methods for making and operating physiological characteristic sensors are presented here. An exemplary method includes providing a quantified effect of an electrical performance parameter on a calculation of a concentration of an analyte in a fluid sample. The method includes providing a group of sensors and testing a test sensor from the group of sensors with a known concentration of the analyte in a test sample to determine the electrical performance parameter of the test sensor. Further, the method includes associating the electrical performance parameter of the test sensor with a selected sensor from the group of sensors. The method may associate the quantified effect with the selected sensor, measure an unknown concentration of the analyte with the selected sensor, and input the measured electrical performance parameter and the quantified effect into an algorithm to provide an estimated blood analyte level.

Abstract: A virtual or augmented reality based system for assessment and measurement of reaction time is disclosed. In various embodiments the system, methods, and computer program products relate to assessing and measuring a reaction time of a patient/user in virtual reality (VR) or augmented reality (AR) environments. The VR/AR system may provide a sensory stimulus to the patient/user in the VR/AR environment, determine a plurality of motion parameters, and determine a reaction time based on the plurality of motion parameters by applying a time window selection model. In various embodiments, a time window shrinkage model may be applied after the time window selection model.

Abstract: Improved systems and methods for improving lean muscle mass monitoring of patients and for identifying and treating at least one of Cachexia or Sarcopenia are disclosed. The system may include a dynamometer provided to patients, the dynamometer being configured to perform remote monitoring. The dynamometer may be used and data may be collected by patients without the supervision of a healthcare professional. Using the collected data, lean muscle mass may be tracked over time, to provide fast and more accurate assessment of conditions. Using such an assessment, early treatment options can be targeted to patients to avoid progression into various disease states, for examples, more severe states of at least one of Cachexia or Sarcopenia.

Abstract: A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.

Abstract: Mobility of a subject can reveal their physical, emotional and mental health, condition. The mobility assessment tracking tool (MATT) system assesses mobility derived by purely objective, reliable and reproducible processes and actions created by specialized computer codes and instructions executed by a logic engine to administer complex bio-mechanical measurements. The MATT system measures a subject's static and dynamic balance and gate mobility locomotion during the subject performing movements of the Tinetti gait and balance test and performing movements of the sports concussion assessment test, SCAT-5. By analyses of data streams from 3-D video with superimposed skeleton notes and from a pressure sensor force board used during these movements, the MATT assess a subject's mobility in accordance to established kinesiology definitions and protocol standards. Repetition of assessments over time allows for the tracking of the subjects' deterioration, maintenance or improvement health condition.

Abstract: A method and system for enabling a practitioner to detect acute stress disorder and PTSD using fMRI comprises looking at functional connectivity dynamics within the visual pathways, limbic, thalamic, paralimbic and prefrontal brain networks observed when individuals are viewing visual images of different facial expressions.

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

Abstract: A sweat sensing device includes a flexible body having a first, outwardly facing surface and a second, skin facing surface and a sweat channel formed in the body, the sweat channel having a first end defining a fluid inlet and a second end. A biochemical assay well formed in the sweat channel and an assay material is disposed in the biochemical assay well, the assay material positioned to react with sweat traveling through the sweat channel and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of the flow of the sweat in the sweat channel.

Abstract: A method for rendering a 3D model of a patient's breast includes: accessing a breast temperature profile representing a temperature distribution across a surface of a patient's breast; generating a 3D model of the patient's breast; overlaying the breast temperature profile onto the 3D model of the patient's breast to generate a 3D temperature profile for the patient's breast; evaluating a thermodynamic model on the 3D temperature profile to estimate the internal temperature distribution within the patient's breast; evaluating a diagnostic model on the internal temperature distribution to estimate a location and a size of a tumor within the patient's breast; and rendering a visual 3D model of the patient's breast representing the location and the size of the tumor within the patient's breast.

Abstract: Segmentation of bony regions in MRI images of joints is automated using a two-stage process. In a first stage, a machine-learning image-slice categorizer is used to categorize image slices of the MRI image data as belonging to one of a set of image-slice categories, depending on presence or absence of bone and/or tendon in the image slice. In a second stage, a first instance of a machine-learning segmentation classifier is used to segment image slices that contain both bone and tendon into bone and non-bone regions, and a second instance of a machine-learning segmentation classifier is used to segment image slices that contain bone but not tendon into bone regions and non-bone regions. Results from the two segmentation classifiers can be combined across image slices to provide a final segmentation of the bony structures, including inflammatory regions, in the image data.

Abstract: An Infant Cry Analyser (ICA) records cries of a neonate and applies acoustic analysis to identify features characteristic of neonatal abstinence syndrome (NAS) or drug withdrawal. The ICA may also receive non-acoustical input, data, such as a medication history, sleep history or other potentially relevant data, and may be configured to output a medical record of the detected data, diagnostic acoustic characteristics or ultimate diagnosis, in one embodiment, the ICA is used on populations of infants to develop normative measures of the characteristics of the infant cries, of the target population, e.g., is used on identified sub-populations such as neonates having laboratory findings of drugs in body fluids, to develop NAS diagnostic criteria or tables. The ICA produces repeatable acoustic measures that reflect, and allows early identification of, other conditions or pathologies in which a cry or vocalization is distinctive of an underlying condition or pathology.

Abstract: Methods, systems, and devices are described for providing risk evaluation and mitigation strategies for use with modified risk products or other tobacco products, and in particular, associated with nicotine and tobacco products.