Patents Issued in May 7, 2020
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Publication number: 20200140339Abstract: Doped titanium niobate is provided, which has a chemical structure of Ti(1-x)M1xNb(2-y)M2yO(7-z)Qz or Ti(2-x?)M1x?Nb(10-y?)M2y?O(29-z?)Qz?, wherein M1 is Li, Mg, or a combination thereof; M2 is Fe, Mn, V, Ni, Cr, or a combination thereof; Q is F, Cl, Br, I, S, or a combination thereof; 0?x?0.15; 0?y?0.15; 0.01?z?2; 0?x??0.3; 0?y??0.9; and 0.01?z??8.Type: ApplicationFiled: November 5, 2019Publication date: May 7, 2020Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Kuan-Yu KO, Po-Yang HUNG, Chi-Ju CHENG, Shih-Chieh LIAO, Yung-Ting FAN, Jin-Ming CHEN
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Publication number: 20200140340Abstract: Provided are a powder for laser manufacturing which can be stably manufactured and from which a three-dimensional manufactured object ensuring a manufacturing accuracy can be obtained and a using method thereof. A powder for ceramic manufacturing for obtaining a manufactured object by repeatedly sintering or fusing and solidifying in sequence a powder in an irradiation portion with laser light, in which the powder includes a plurality of constituent materials, at least one constituent material of the constituent materials is an absorber that relatively strongly absorbs the laser light compared to other constituent materials, and at least a part of the absorber changes to a different constituent material that relatively weakly absorbs the laser light by irradiation with the laser light and a using method of a powder in which the powder is used.Type: ApplicationFiled: January 7, 2020Publication date: May 7, 2020Inventors: Nobuhiro Yasui, Hisato Yabuta, Kanako Oshima, Hiroshi Saito, Yoshihiro Ohashi, Makoto Kubota, Akira Uebayashi
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Publication number: 20200140341Abstract: A method for producing nanoparticulate compressed tablets/pellets from synthetic and/or natural materials, and compressed tablets/pellets produced using the method for producing nanoparticulate compressed tablets/pellets from synthetic and/or natural materials and to uses thereof.Type: ApplicationFiled: June 5, 2018Publication date: May 7, 2020Inventors: Carl-Dieter Garbe-Schoenberg, Samuel Mueller, Simon Nordstad
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Publication number: 20200140342Abstract: An admixture for concrete includes at least two different types of nanocarbon particles in a water/surfactant mixture having a predetermined percentage range by mass of the admixture. The admixture also includes surfactant and can include a nano-silica based suspension stabilizer having a predetermined percentage range by mass of the admixture.Type: ApplicationFiled: December 20, 2019Publication date: May 7, 2020Applicant: EDEN INNOVATIONS LTD.Inventors: Justin Fulton, GREGORY H. SOLOMON, ROGER W. MARMARO, ROBERT CAVALIERO, ALLAN GODSK LARSEN, SHAWN MEREDITH, CHRISTOPHER FLATLEY ABATELLI
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Publication number: 20200140343Abstract: A concrete curing blanket that includes a vapor barrier layer, a wicking layer, and pH-indicator, such as turmeric or Phenol Red incorporated into the concrete curing blanket. The pH-indicator may be a power or prills attached to the vapor barrier, the wicking layer, or another layer of the concrete curing blanket. Alternatively, the pH-indicator may be a series of ribbons or strips attached to the vapor barrier, the wicking layer, or another layer of the concrete curing blanket. As another alternative, the pH-indicator may be a matrix of discontinuous patches attached to the vapor barrier, the wicking layer, or another layer of the concrete curing blanket. As another alternative, the vapor barrier may include perforations.Type: ApplicationFiled: November 7, 2018Publication date: May 7, 2020Inventor: Stephen F. McDonald
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Publication number: 20200140344Abstract: Disclosed are a semi-transparent ceramic sheet decorated through ink light-absorbance and a preparation method thereof. The semi-transparent ceramic sheet comprises a semi-transparent green body, an inner inkjet pattern layer infiltrating into the semi-transparent green body from an upper surface of the semi-transparent green body, a decoloration glaze layer located on the upper surface, and a surface pattern layer located on the decoloration glaze layer. The decoloration glaze layer is capable of decoloring the ink of the inner inkjet pattern layer. The semi-transparent ceramic sheet is provided with the decoloration glaze layer so that the inkjet decoration of the inner inkjet pattern layer cannot be displayed on the surface, and the decorative pattern on the surface of the green body is the surface pattern layer and the inner inkjet pattern layer is completely in the inner layer of the green body.Type: ApplicationFiled: March 16, 2018Publication date: May 7, 2020Applicant: Monalisa Group Co., Ltd.Inventors: Libiao XIAO, Limin PAN, Zhouqiang FAN, Yijun LIU, Junle DONG, Lingyan HUANG
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Publication number: 20200140345Abstract: A method for forming a protective coating on a surface of a ceramic substrate includes combining a rare-earth oxide, alumina, and silica to form a powder, etching the surface of the ceramic substrate, applying the powder on the etched surface in an amount of from about 0.001 to about 0.1 g/cm2 to reduce capture of bubbles from off-gassing of the ceramic substrate, heating the powder for a time of from about 5 to about 60 minutes to a temperature at or above the melting point such that the powder melts and forms a molten coating on the surface that has a minimized number of bubbles, and cooling the molten coating to ambient temperature to form the protective coating disposed on and in direct contact with the surface of the ceramic substrate such that the protective coating has a thickness of less than about 1 mil.Type: ApplicationFiled: November 7, 2018Publication date: May 7, 2020Applicant: HONEYWELL INTERNATIONAL INC.Inventors: Terence Whalen, Bahram Jadidian, Reza Oboodi
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Publication number: 20200140346Abstract: Method for the production of organic fertilizer comprising providing an organic source of ammonia gas, in particular air contaminated with ammonia gas, directing the air contaminated with ammonia gas through water and forming an ammonium hydroxide solution converting the ammonium into nitrate, dosing, under the control of a control system, the ammonium hydroxide solution to a recirculation stream from a second bio-reactor with bacteria suitable for converting the supplied ammonia into nitrite and nitrate. The amount of ammonium water fed by the control system to the acidic nitrate solution from the second bio-reactor depends on one or more measured pH values in the device.Type: ApplicationFiled: July 4, 2018Publication date: May 7, 2020Inventor: Petrus Franciscus KLEIN
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Publication number: 20200140347Abstract: The present disclosure provides a method of increasing the concentration of K2O in an aqueous solution. The method comprises reacting potassium sulfate with an acidic compound to yield a product that includes potassium hydrogen sulfate. The product can be used to supplement crops in need of potassium. The product can also have other nutrients added to it, depending on the desired end use. Advantageously, these products increase yield as compared to prior art products.Type: ApplicationFiled: November 7, 2019Publication date: May 7, 2020Inventors: Robert A. Geiger, Kristopher Lee Shelite, Steffen M. Ball, Vatren Jurin
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Publication number: 20200140348Abstract: A fertilizer derived from an organic source and a method of making are provided. The fertilizer of the present invention advantageously has a nitrogen content greater than 4%. The method of making the fertilizer also produces potable water.Type: ApplicationFiled: December 31, 2019Publication date: May 7, 2020Inventor: Denise Crabtree
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Publication number: 20200140349Abstract: A procedure for producing a liquid fertilizing product from a biosolids cake that has been de-watered to a biosolids content of 18% or more. The procedure includes positioning a process amount of the biosolids cake in a reactor vessel, heating the biosolids cake process amount, and adding a quantity of an alkali and mixing it into the process amount of the biosolids cake to form a reactor mixture. The reactor mixture incubated for a period, and then cooled. The alkali includes pH-raising and hydrolysis-procuring components. The quantity of alkali in relating to the biosolids process amount is sufficient that a residual amount of the alkali remains in the cooled reactor mixture, the pH of the reactor mixture remains at a saturation level during and after the incubation period, and the cooled reaction mixture is pumpable.Type: ApplicationFiled: June 15, 2018Publication date: May 7, 2020Applicant: LYSTEK INTERNATIONAL CORP.Inventor: Owen Patrick Ward
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Publication number: 20200140350Abstract: The present invention relates to a composition, system and method for the promotion of soil health, and hence plants grown in the soil treated with the composition. The present invention may be used for the improvement of soils that are deficient in or depleted of nutrients, minerals, microorganisms or moisture (or any one or more of these), and are in need of “rehabilitation.” However, the invention is equally suited to establishing and maintaining the health of any soil (and plant) ecosystem. The composition includes live nitrogen-fixing bacteria and fungi that form symbiotic relationship with plants to increase the bioavailability of nitrogen in the soil.Type: ApplicationFiled: June 22, 2018Publication date: May 7, 2020Inventor: Dugald Ross HAMILTON
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Publication number: 20200140351Abstract: An organic fertilizer with one or more natural ingredients is provided. The organic fertilizer includes molasses to provide additional nutrients to the soil that are readily available for plant intake such as providing sugars to increase microorganism activity. An aromatic ingredient is provided to mask the unwanted odors of other fertilizer components.Type: ApplicationFiled: January 3, 2020Publication date: May 7, 2020Inventor: Paul M. Kalmbach
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Publication number: 20200140352Abstract: The present disclosure provides a seeding formulation for woody plants and a pre-treatment of surfaces (e.g. rocks, waste rocks, tailings, overburden) on disturbed and degraded lands. The seeding formulation includes a mix of woody trees or shrubs seeds, organic mulch, beneficial microbial populations, mineral fertilizer, adhesive, absorbent polymer, and water. The pre-treatment of surfaces refers to the spreading or mixing of surfaces with organic biomass. Methods of preparing and applying the seeding formulation and pre-treatment are also disclosed. The formulation is used for the phytoremediation, ecological restoration, land reclamation, environmental rehabilitation, revitalization, revegetation, and reforestation of disturbed and degraded lands.Type: ApplicationFiled: January 7, 2020Publication date: May 7, 2020Applicant: VIRIDIS TERRA INNOVATIONSInventors: Martin BEAUDOIN NADEAU, Donald BLOUIN, Frank GRENON
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Publication number: 20200140353Abstract: Fertilizer particles with urease inhibitors and nitrification inhibitors are described herein. The fertilizer particles can include a core particle comprising a urease inhibitor and an outer layer comprising a nitrification inhibitor.Type: ApplicationFiled: April 12, 2018Publication date: May 7, 2020Applicant: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Ravi HEGDE, Rajamalleswaramma KORIPELLY, Chandra MOHANA, Radha ACHANATH, Samik GUPTA, Sabeshan KANAGALINGAM
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Publication number: 20200140354Abstract: The present invention relates to a process for the conversion of methanol in p-xylene comprising the use a molding which comprises a zeolitic material, phosphorous, one or more metals M of the groups 3, 6, 10 to 14 of the periodic system of the elements, and a binder material.Type: ApplicationFiled: April 24, 2018Publication date: May 7, 2020Inventors: Robert MCGUIRE, Christiane KURETSCHKA, Sven TITLBACH, Ekkehard SCHWAB, Ulrich MÜLLER
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Publication number: 20200140355Abstract: A turbulent fluidized bed reactor, device and method for preparing para-xylene and co-producing light olefins from methanol and/or dimethyl ether and toluene, resolving or improving the competition problem between an MTO reaction and an alkylation reaction during the process of producing para-xylene and co-producing light olefins from methanol and/or dimethyl ether and toluene, and achieving a synergistic effect between the MTO reaction and the alkylation reaction. By controlling the mass transfer and reaction, competition between the MTO reaction and the alkylation reaction is coordinated and optimized to facilitate a synergistic effect of the two reactions, so that the conversion rate of toluene, the yield of para-xylene, and the selectivity of light olefins are increased. The turbulent fluidized bed reactor includes a first reactor feed distributor and a number of second reactor feed distributors and are arranged sequentially along the gas flow direction.Type: ApplicationFiled: November 24, 2017Publication date: May 7, 2020Applicant: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Mao YE, Tao ZHANG, Zhongmin LIU, Jinling ZHANG, Hailong TANG, Jinming JIA, Changqing HE, Xiangao WANG, Cheng ZHANG, Hua LI, Yinfeng ZHAO, Chenggong LI
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Publication number: 20200140356Abstract: Systems and methods for producing propylene using an MTBE synthesis raffinate are disclosed. An MTBE synthesis raffinate stream first passes through a molecular sieve to separate n-butane and isobutane from the rest of C4 hydrocarbons of the MTBE synthesis raffinate. The 1-butene in the rest of C4 hydrocarbons of the MTBE synthesis raffinate is then isomerized to form 2-butene. Therefore, the concentration of 2-butene in the subsequent propylene production process increases due to the separation of n-butane and isobutane and the isomerization of 1-butene, resulting in an improved reaction rate and reaction efficiency for propylene production.Type: ApplicationFiled: July 17, 2018Publication date: May 7, 2020Inventors: Guillermo LEAL, Mohammed Bismillah ANSARI
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Publication number: 20200140357Abstract: The present invention relates to a process for modifying the fluorine distribution in a hydrocarbon compound, comprising a step of placing in contact between a hydrocarbon compound and a catalytic composition comprising a chromium-based catalyst, said process being performed in a reactor made of a material comprising a base layer made of a material M1 and an inner layer made of a material M2, said base layer and said inner layer being laid against each other, characterized in that the material M2 comprises at least 80% by weight of nickel on the basis of the total weight of the material M2, advantageously at least 90% by weight, preferably at least 95% by weight, in particular at least 99% by weight of nickel on the basis of the total weight of the material M2.Type: ApplicationFiled: June 5, 2018Publication date: May 7, 2020Inventors: Dominique DEUR-BERT, Anne PIGAMO, Laurent WENDLINGER
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Publication number: 20200140358Abstract: The present invention relates to a process for the production of semifluorinated alkanes.Type: ApplicationFiled: May 4, 2018Publication date: May 7, 2020Inventor: Lorenz LÖRSCH
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Publication number: 20200140359Abstract: The invention discloses a method for catalytically hydrogenating oxalates. In the method, an oxalate and hydrogen gas are contacted with a nanotube assembled hollow sphere catalyst, to produce a product comprising glycolate or glycol. The predominant chemical components of the catalyst include copper and silica, in which the copper is in an amount of 5 to 60% by weight of the catalyst, and the silica is in an amount of 40-95% by weight of the catalyst. The catalyst has a specific surface area of 450-500 m2/g, an average pore volume of 0.5-1 cm3/g, and an average pore diameter of 5-6 nm. The catalyst is in a structure of assembling nanotubes on hollow spheres, wherein the hollow spheres have a diameter of 50-450 nm, and a wall thickness of 10-20 nm, and the nanotubes, vertically arranged on the surfaces of the hollow spheres, have a diameter of 3-5 nm, and a length of 40-300 nm.Type: ApplicationFiled: March 26, 2018Publication date: May 7, 2020Inventors: Xinbin MA, Yue WANG, Dawei YAO, Jing LV, Yujun ZHAO, Shengping WANG
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Publication number: 20200140360Abstract: The present invention provides a method for producing indancarbaldehyde, including a step of reacting indan with carbon monoxide in the presence of hydrogen fluoride and boron trifluoride to obtain a reaction liquid including indancarbaldehyde, wherein the indan includes an amine, and a content of the amine is less than 1000 ppm by mass.Type: ApplicationFiled: March 9, 2018Publication date: May 7, 2020Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventor: Tatsuya UTAMURA
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Publication number: 20200140361Abstract: In one aspect, a hydroformylation reaction process comprises contacting an olefin, hydrogen, and CO in the presence of a homogeneous catalyst in a cylindrical reactor to provide a reaction fluid, wherein the reactor has a fixed height, and wherein a total mixing energy of at least 0.5 kW/m3 is delivered to the fluid in the reactor; removing a portion of the reaction fluid from the reactor; and returning at least a portion of the removed reaction fluid to the reactor, wherein the returning reaction fluid is introduced in at least two return locations positioned at a height that is less than 80% of the fixed height, wherein the at least two return locations are positioned above a location in the reactor where hydrogen and carbon monoxide are introduced to the reactor, and wherein at least 15% of the mixing energy is provided by the returning reaction fluid.Type: ApplicationFiled: June 19, 2018Publication date: May 7, 2020Inventors: Michael C. Becker, Donald L. Campbell, Irvin B. Cox, Shankhadeep Das, Seshadri Kumar, Glenn A. Miller, Nilesh Parmar, George R. Phillips
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Publication number: 20200140362Abstract: The invention relates to a method for separating acetone from acetone/water mixtures, according to which a partial flow of the acetone/water mixture is concentrated in a column operating under positive pressure in order to obtain a product with an acetone concentration of at least 80 wt. %, and a partial flow of the acetone/water mixture is concentrated in a column operating under normal pressure. The top product from the column operated under positive pressure is used to heat the bottom product of the column operated under normal pressure, by means of a heat exchanger, and the top product is then introduced into the column operated under normal pressure, above the supply of the partial flow of the acetone/water mixture. This method allows the specific energy demand for acetone separation to be significantly reduced, thereby presenting considerable cost advantages. The invention also relates to a device for carrying out such a method.Type: ApplicationFiled: April 26, 2018Publication date: May 7, 2020Inventors: Andreas Hummel, Thomas Krumrey
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Publication number: 20200140363Abstract: Provided is a process for preparing methacrolein which maximizes capture of methanol. Also provided are processes for producing methacrylic acid and methyl methacrylate.Type: ApplicationFiled: May 24, 2018Publication date: May 7, 2020Inventors: Reetam Chakrabarti, Dmitry A. Krapchetov, Mark A. Silvano, Jinsuo Xu
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Publication number: 20200140364Abstract: The disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4 are as described herein. The disclosure also provides methods for identifying a compound that selectively kills polyploid cells, and methods for killing polyploid tumor cells by administering a compound of Formula I to a patient in need thereof.Type: ApplicationFiled: May 21, 2018Publication date: May 7, 2020Inventors: Dun Yang, Jing Zhang, Shenqiu Zhang
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Publication number: 20200140365Abstract: A process for producing acetic acid that involves operating the flash vessel and first column at the lowest possible pressure for a given production rate is described. Low pressures are achieved by operating on a back pressure established by a vapor discharge from an absorbing system. This reduces the pressure differential to allow steady and efficient acetic acid production.Type: ApplicationFiled: November 2, 2018Publication date: May 7, 2020Inventor: Ronald D. SHAVER
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Publication number: 20200140366Abstract: Provided is an acetic acid production method that enables, in a scrubbing system, efficient separation and obtaining of methyl iodide and an absorbing solvent; restrainment of corrosion of the interior of a distillation column; efficient separation between and recovery of hydrogen iodide and methyl iodide; or sufficient recovery of hydrogen iodide. The acetic acid production method according to the present invention includes a first absorption step and a second absorption step. In the first absorption step, an offgas is brought into contact with a first absorbent to allow the first absorbent to absorb an iodine compound from the offgas, to give a first gas, where the first absorbent includes at least one of C2 or higher alcohols, esters of C3 or higher carboxylic acids, esters between carboxylic acids and C2 or higher alcohols, ethers, ketones, water, and basic aqueous solutions.Type: ApplicationFiled: July 2, 2018Publication date: May 7, 2020Applicant: DAICEL CORPORATIONInventor: Masahiko SHIMIZU
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Publication number: 20200140367Abstract: Polystyrene-containing polymers are converted to benzoic acid by catalytic oxidation of dissolved polystyrene under elevated temperature and pressure. The produced benzoic acid is recovered by evaporation.Type: ApplicationFiled: July 10, 2018Publication date: May 7, 2020Inventor: David Lee Sikkenga
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Publication number: 20200140368Abstract: Compounds derived from biomass, e.g., cellulose and lignins, methods of forming such compounds and polymers and products formed using such compounds.Type: ApplicationFiled: December 20, 2019Publication date: May 7, 2020Applicant: NDSU RESEARCH FOUNDATIONInventors: Mukund P. Sibi, Selvakumar Sermadurai, Nicolas Zimmermann, Eric Serum, Gaoyuan Ma, Ramkumar Moorthy, Krystal Kalliokoski
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Publication number: 20200140369Abstract: The present invention relates to a derivative of 13-oxidized ingenol, use thereof in the prevention and/or treatment of a disease associated with proliferation or tumor in a subject, or a cosmetic indication, and use thereof in the prevention and/or treatment of a disease responsive to neutrophil oxidative burst, a disease responsive to a release of IL-8 by keratinocyte, or a disease responsive to induction of necrosis.Type: ApplicationFiled: June 7, 2018Publication date: May 7, 2020Applicant: Tianjin Zhongxin Pharmaceutical Group Corp., LTD. Research Institute Branch CompanyInventors: Xiao Wu, Qin Pan, Yanyun Li, Yu Yang, Yuzhen Guan, Xioalei Wu, Chuanteng Sun, Yuan Wang
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Publication number: 20200140370Abstract: The invention relates to novel ester compounds of the general formula (I) to a process for preparation thereof and to the use thereof. These ester compounds may contain a mixture of at least two compounds of the general formula (I).Type: ApplicationFiled: April 11, 2018Publication date: May 7, 2020Inventors: Tobias Betke, Carmen Plass, Harald Gröger, Dirk Loderer, Stefan Seemeyer, Thomas Kilthau, Ling Ma
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Publication number: 20200140371Abstract: In various embodiments a compound comprising the enantiomerically enriched S-isomer S-BHB-S-1,3-butanediol is provided along with methods of use thereof.Type: ApplicationFiled: July 19, 2018Publication date: May 7, 2020Inventors: Eric Verdin, John C. Newman
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Publication number: 20200140372Abstract: A method for preparing a nitrate ester is provided. The method includes providing a first solution including a compound (which has at least one hydroxyl group) and a carboxylic acid having 2-5 carbon atoms; providing a second solution including nitric acid, acetic anhydride, and acetic acid; and transferring the first solution and the second solution to a microreactor, obtaining a nitrate ester after a residence time. In particular, the ratio of the weight of nitric acid to the total volume of the acetic anhydride and acetic acid is 1:1 to 1:3.5. The ratio of the molar amount of nitric acid to the hydroxyl group equivalent of the compound is from 1:1 to 15:1.Type: ApplicationFiled: May 15, 2019Publication date: May 7, 2020Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chih-Lung CHIN, Shih-Hsien LIU, Wan-Chi CHEN, Kung-Lung CHENG
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Publication number: 20200140373Abstract: The invention relates to a process for the preparation of a compound represented by formula (I) wherein X is selected from the group consisting of —H, -halogen, linear or branched C1-C7 alkyl group, linear or branched C1-C5 alkoxy group, —NO2 and —CN and Y is a linear or branched C1-C7 alkyl group, comprising the steps of: 10 a) reacting a compound represented by formula (II) with a compound represented by (III) to obtain an intermediate product, wherein X is as defined with respect to formula (I), wherein Z is H, CH3 or C2H5, b) reacting the intermediate product of step a) with a compound represented by Y2SO4 (IV) wherein Y is as defined with respect to formula (I) to obtain a salt and c) hydrolyzing the salt of step b) to obtain the compound of formula (I).Type: ApplicationFiled: June 11, 2018Publication date: May 7, 2020Inventors: Prashant Sukumar Shinge, Jaiprakash Brijlal Sainani
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Publication number: 20200140374Abstract: The present invention relates to alkoxylated esteramines of Formula (I) and salts thereof. Esteramines according to the present invention may be used in cleaning composition, for example in liquid laundry detergents. They lead to improved cleaning performance of said compositions, for example when used in cold water washing conditions. They surprisingly boost grease cleaning performance of liquid laundry detergents, especially under cold water washing conditions. Whiteness is also improved. The esteramine according to the present invention show improved compatibility in liquid laundry detergent formulations.Type: ApplicationFiled: June 26, 2018Publication date: May 7, 2020Inventors: Bjoern LUDOLPH, Sophia EBERT, Christian BITTNER
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Publication number: 20200140375Abstract: Compositions and methods for treating conditions associated with altered TCA cycle metabolism are provided.Type: ApplicationFiled: July 24, 2018Publication date: May 7, 2020Applicants: IMBRIA PHARMACEUTICALS, INC., IMBRIA PHARMACEUTICALS, INC.Inventor: Andrew D. Levin
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Publication number: 20200140376Abstract: The invention relates to resorcinol-derived compounds of formula (I) and also the salts thereof, the solvates thereof and the optical and/or geometrical isomers thereof, including enantiomers and diastereoisomers, the racemic mixtures thereof, alone or as a mixture. The invention also relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, in particular the skin, using these compounds (I).Type: ApplicationFiled: May 30, 2018Publication date: May 7, 2020Inventors: Xavier MARAT, Chunyu MA
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Publication number: 20200140377Abstract: A compound of the formula (III): wherein R21 is a hydrogen atom or an alkyl group; R22 is a hydrogen atom or an alkyl group; and R23 is a divalent organic group.Type: ApplicationFiled: January 2, 2020Publication date: May 7, 2020Applicants: DAIKIN INDUSTRIES, LTD., TOKYO INSTITUTE OF TECHNOLOGYInventors: Tadashi KANBARA, Tsuyoshi Noguchi, Toshikazu Takata, Hiromitsu Sogawa, Shunsuke Monjiyama, Toyokazu Tsutsuba
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Publication number: 20200140378Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.Type: ApplicationFiled: January 15, 2020Publication date: May 7, 2020Applicant: The Board of Regents of the University of Texas SystemInventors: Daniel J. SIEGWART, Jason B. MILLER
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Publication number: 20200140379Abstract: The present invention provides a method for producing methionine which is characterized by comprising (1) a reaction step: a step of hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of an alkali compound to obtain a reaction solution containing an alkali salt of methionine, (2) a first crystallizing step: a step of introducing carbon dioxide into the reaction solution and precipitating methionine from the reaction solution to obtain the first crystal of methionine and the first crystal mother liquor, and (3) a second crystallizing step: a step in which after obtaining a slurry which contains precipitates containing the second crystals of methionine precipitated by introducing carbon dioxide to the first crystal mother liquor and the slurry was subjected to centrifugation to separate the second crystal of methionine and the second crystal mother liquor by a solid-liquid separation, and the precipitate remained in the obtained second crystal mother liquor is separated using a filter.Type: ApplicationFiled: April 27, 2018Publication date: May 7, 2020Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Norihito OMOTO, Yoshitaka SATOH, Masayuki MORIKAWA, Yoshiyuki KOIZUMI, Naoya YAMASHIRO, Ryousuke KATAGAMI
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Publication number: 20200140380Abstract: What is described is a method of synthesis of the compound of formula 1A, or a salt thereof, wherein R3 is a linear or branched alkene of 1, 2, 3, 4, 5 or 6 carbons; R4 and R5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; and L3 is a bond or an alkane of 1, 2, 3, 4, 5 or 6 carbons.Type: ApplicationFiled: March 19, 2018Publication date: May 7, 2020Inventors: Joseph E. Payne, Padmanabh Chivukula
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Publication number: 20200140381Abstract: Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings.Type: ApplicationFiled: February 17, 2017Publication date: May 7, 2020Applicants: Dana-Farber Cancer Institute, Inc., Centre Hospitalier Universitaire Vaudois, President and Fellows of Harvard College, The General Hospital CorporationInventors: Sara Jean Buhrlage, Anders Näär, Gerhard Wagner, Haribabu Arthanari, Joy Luz Nishikawa, Andras Pal Boeszoermenyi, Dominique Sanglard
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Publication number: 20200140382Abstract: The present invention relates to novel heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as the compounds of the invention belong to the family of NOD-like receptor family (NLR) protein NLRP3 modulators. The present invention thus relates to novel NLRP3 modulators as well as to the use of the novel inhibitor compounds in the treatment of diseases or conditions as well as treatment of disease states mediated by NLRP3 as well as treatment of diseases or conditions in which interleukin 1? activity and interleukin-18 (IL-18) is implicated.Type: ApplicationFiled: June 8, 2018Publication date: May 7, 2020Applicant: CADILA HEALTHCARE LIMITEDInventors: Rajiv SHARMA, Pravin IYER, Sameer AGARWAL
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Publication number: 20200140383Abstract: The invention is directed to substituted azetidine derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein C, D, L1, L2, L3, R1, R2, R4, R5, R6, z2, z4, z5, and z6 are as defined herein; and salts thereof. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.Type: ApplicationFiled: July 2, 2018Publication date: May 7, 2020Inventors: Mui CHEUNG, Michael P. DEMARTINO, Biswajit KALITA, Rajendra KRISTAM
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Publication number: 20200140384Abstract: The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.Type: ApplicationFiled: September 30, 2019Publication date: May 7, 2020Inventors: Brian W. Metcalf, Zhe Li, Qing Xu, Kobina N. Dufu, James Partridge, Hing Sham, Ming Yu
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Publication number: 20200140385Abstract: The invention relates to a crystalline form of [(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)-piperidine-3,4,5-triol, processes for the preparation thereof, pharmaceutical compositions containing such a crystalline form, and its use as a medicament, especially as glycolipid biosynthesis inhibitor.Type: ApplicationFiled: May 31, 2018Publication date: May 7, 2020Inventors: Vitor OLIVEIRA, Ivan POGORELIC, Jean-Paul RODUIT
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Publication number: 20200140386Abstract: The present invention describes novel diamino pyridine derivatives exhibiting JAK modulating properties. The present invention also relates to pharmaceutical compositions comprising these novel compounds, methods of using said compounds in the treatment of various diseases and disorders being susceptible to JAK modulation, and processes for preparing the compounds described hereinafter.Type: ApplicationFiled: January 8, 2020Publication date: May 7, 2020Inventor: Gebhard THOMA
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Publication number: 20200140387Abstract: Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed compounds have a structure according to general formula I or a pharmaceutically acceptable salt thereof: wherein “” represents a single or double bond, R1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ra is hydrogen, —CH2R2, R3, or —SO2R4; R2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R4 is lower aliphatic, or substituted or unsubstituted aryl; and R5 is hydrogen, halogen, or lower aliphatic.Type: ApplicationFiled: June 18, 2019Publication date: May 7, 2020Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Patrick Joseph Pagano, Peter Wipf, Maria Eugenia Cifuentes-Pagano, Erin M. Skoda
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Publication number: 20200140388Abstract: Provided herein are methods, systems, kits, and compositions useful for determining small molecule-protein interactions and protein-protein interactions. The photo-click tags provided herein can be conjugated to a small molecule or amino acid analog to provide compounds that can be integrated into a protein through photo-conjugation, allowing for identification of a small molecule-protein interaction or protein-protein interaction to elucidate the small molecules mechanism of action or the protein targeted by the small molecule. In some embodiments, the photo-click tags comprise a photo-conjugation moiety and a click chemistry handle, allowing for the attachment of various functional groups (e.g., affinity tags) to the small molecule or amino acid analog.Type: ApplicationFiled: June 6, 2018Publication date: May 7, 2020Applicant: President and Fellows of Harvard CollegeInventors: Christina M. Woo, Jinxu Gao, Yuka Amako, Chia Fu Chang, Zhi Lin, Hung-Yi Wu