Patents Issued in May 14, 2020
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Publication number: 20200148596Abstract: A corrosion-resistant member may include alumina ceramics containing ?-alumina and anorthite. The alumina ceramics may contain 0.4% by mass or more of Ca and Si in total in terms of CaO and SiO2, respectively, and a mass ratio of CaO/SiO2 may fall within a range of 0.5 to 2. Moreover, a ratio B/A of X-ray diffraction peak intensity B for (004) plane of the anorthite to X-ray diffraction peak intensity A for (104) plane of the ?-alumina in a surface of the alumina ceramics, may be 0.01 or more.Type: ApplicationFiled: December 26, 2017Publication date: May 14, 2020Inventors: Shuichi IIDA, Mizuho OOTA, Satoshi TOYODA, Hidehiro TAKENOSHITA
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Publication number: 20200148597Abstract: A refractory article includes a body having a first portion defining at least a portion of a first exterior surface of the body, the first portion including a carbide, and further including a second portion defining at least a portion of a second exterior surface of the body opposite the first exterior surface, the second portion including an oxide, and a thermal conductivity difference (?TC) of at least 10 W/mK between the first exterior surface and the second exterior surface, and an average Shell Temperature of not greater than 400° C.Type: ApplicationFiled: November 13, 2019Publication date: May 14, 2020Inventors: Julio Cesar T. SPADACCIA, Nancy F. LEVOY, Allan R. CASE, Craig J. IOZZO
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Publication number: 20200148598Abstract: An aluminum nitride sintered compact containing aluminum nitride crystal grains and composite oxide crystal grains containing a rare earth element and an aluminum element, wherein a median diameter of the aluminum nitride crystal grains is 2 ?m or less; 10 to 200 intergrain voids having a longest diameter of 0.2 to 1 ?m are dispersed in a region of a cross section of 100 ?m in square; and the carbon atom content is less than 0.10% by mass. Also disclosed is a method of producing the aluminum nitride sintered compact.Type: ApplicationFiled: July 19, 2018Publication date: May 14, 2020Applicant: SHOWA DENKO K.K.Inventors: Daisuke MIYAMOTO, Kosuke SHIOI
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Publication number: 20200148599Abstract: The invention relates to a sliding member having a first sliding surface, wherein the first sliding surface (29) comprises a particulate support material (6) and a graphene-containing material (7), wherein the particulate support material (6) is at least partially coated with the graphene-containing material (7), and wherein a material bond (14) is present between the particulate support material (6) and the graphene-containing material (7).Type: ApplicationFiled: July 5, 2018Publication date: May 14, 2020Applicant: EagleBurgmann Germany GmbH & Co. KGInventors: Rolf Mulhaupt, Jorg Thomas Thelke, Wenli Zhang
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Publication number: 20200148600Abstract: A process for densification of a ceramic matrix composite comprises forming a reinforcing ceramic continuous fiber stack having a central zone bounded by an outer zone adjacent; locating first particles within the central zone; coating the first particles and the ceramic fibers with silicon carbide through chemical vapor infiltration; locating second particles within the outer zone; coating the second particles and the ceramic fibers with silicon carbide through chemical vapor infiltration; forming the stack into a predetermined three dimensional shape; and densifying the stack.Type: ApplicationFiled: November 9, 2018Publication date: May 14, 2020Applicant: United Technologies CorporationInventors: Ying She, James T. Beals, Xia Tang, Richard Wesley Jackson
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Publication number: 20200148601Abstract: The present invention relates to a system and method for the production of gypsum board using starch pellets. In accordance with the present disclosure, the starch necessary for board formation is provided in the form of starch pellets. These pellets are mixed with a gypsum slurry in a mixer. The pellets are initially insoluble and do not dissolve. However, during subsequent drying stages, the pellets become soluble and dissolve into the gypsum phase. This both provides the desired starch component and also results in the formation of voids within the set gypsum.Type: ApplicationFiled: January 14, 2020Publication date: May 14, 2020Inventors: John W. College, Shane Libunao, Mark Harris
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Publication number: 20200148602Abstract: A ceramic and plastic composite includes a ceramic matrix and a plastic layer. Plastics are injected onto the surface of the baked ceramic matrix to form a plastic layer. The plastic layer more deeply fills nanoholes distributed on the surface of the ceramic matrix to have higher adhesion. Thus, the higher combined strength and air tightness exist between the ceramic matrix and the plastic layer to improve the reliability and the using performance of the ceramic and plastic composite.Type: ApplicationFiled: January 15, 2020Publication date: May 14, 2020Inventors: Wen-Tung CHANG, Jong-Yi SU
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Publication number: 20200148603Abstract: The consortium comprises the Clostridium pasteuranium. Bacillis thuringiensis, Bacillus megaterium, Bacillus btilis, Azotobacter vinelandii and Rhizobium sp micro-organisms, which are subjected to increasing concentrations of thiodicarb and biphenthrin in order to render them tolerant to these compounds without manipulating their genome. The use of the consortium in the form of a liquid biofertiliser enriches the soil with bacteria which, besides being resistant to thiodicarb and biphenthrin, capture atmospheric nitrogen, solubilise phosphor and act against some pathogens.Type: ApplicationFiled: January 30, 2019Publication date: May 14, 2020Applicant: Salus Mundi Investments LimitedInventor: Luis Orlando Castro Cabrera
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Publication number: 20200148604Abstract: A food recycler can include a housing defining an interior and an access opening to the interior. A mixing bin can be located within the interior and can have an inlet and an outlet. The food recycler can further include an output bin, the output bin having an inlet. The outlet of the mixing bin can couple or connect to the inlet of the output bin.Type: ApplicationFiled: November 13, 2018Publication date: May 14, 2020Inventors: WADE ATKINSON, MOHSIN MAHAMADSHAFI ATTAR, ABHISHEK PRADEEP BUZRUK, RAJWARDHAN DESHMUKH, RACHEL MAGHAS, BHUSHAN VIJAY PATIL, HERON PLAZA RICO
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Publication number: 20200148605Abstract: The invention is directed to coated fertilizer granules and methods for manufacturing granules and using organically enhanced inorganic fertilizer granules, which incorporate a coating of one or more concentric layers over a core such that the coating contains a bioactive agent such as a herbicide, pesticide, plant growth regulator, microorganism, or beneficial element. Application of the coating to the fertilizer granule preferably involves binding of the bioactive agent to the surface of granule or to the organic components within the granule. The release of the bioactive agent from the coating and or the surface of the granule preferably results in a two-phased release, a first fast release and a second extended or slow-release of the bioactive agent into the soil metering the bioavailability of the bioactive agent for crop growth or protection, and/or for controlling unwanted vegetation or pests.Type: ApplicationFiled: November 13, 2019Publication date: May 14, 2020Applicant: Anuvia Plant Nutrients CorporationInventors: Jeffrey C. Burnham, Sanford A. Siegel
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Publication number: 20200148606Abstract: An inhibitor composition contains alkyl thiophosphoric triamide (or a mixture of alkyl thiophosphoric triamide and dicyandiamide), dissolved in a liquid medium comprising at least one organic solvent, at least one amine stabilizer and, optionally, at least one dye and/or at least one odor masking agent, is useful in making fertilizer compositions and in a method of fertilizing target plants.Type: ApplicationFiled: January 20, 2020Publication date: May 14, 2020Applicant: RHODIA OPERATIONSInventors: Hong LIU, Jiamin WU, Andre GOMES, Krish SHANMUGA, Zhiyun CHEN
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Publication number: 20200148607Abstract: A calcium sulfate urea (UCS) fertilizer granule and methods for making and using the same are disclosed. The granule can include urea, calcium sulfate, and a calcium sulfate urea adduct, wherein a portion of the surface of the calcium sulfate urea adduct includes a layer comprising urea, calcium sulfate, or calcium sulfate urea adduct, or any combination or all thereof.Type: ApplicationFiled: July 19, 2018Publication date: May 14, 2020Applicant: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Harri KIISKI, Andrew George KELLS, Mohamed Akasha M. KHALEEL, Nilkamal BAG
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Publication number: 20200148608Abstract: A method is provided for producing a biochar solution. The method comprises the steps of collecting biochar particles, dispersing the biochar particles in a liquid solution and adding a stabilizing agent to keep the biochar in flowable suspension. The stabilizing agent may be added to the liquid solution or to the biochar prior to placing the biochar in solution.Type: ApplicationFiled: November 11, 2019Publication date: May 14, 2020Applicant: Cool Planet Energy Systems, Inc.Inventors: Mark Lahman Jarand, Daren Einar Daugaard, Timothy Alan Thompson, Han Suk Kim, Michael William Metier
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Publication number: 20200148609Abstract: A tackifier is used resin in an energic material formulation comprising active materials and a polymeric binder to reduce or eliminate the use of a plasticiser in the formulation wherein the tackifier resin is compatible with the polymeric material.Type: ApplicationFiled: April 10, 2018Publication date: May 14, 2020Inventors: Kenneth Lewtas, Daniel Jubb, Mark Price
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Publication number: 20200148610Abstract: The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.Type: ApplicationFiled: January 14, 2020Publication date: May 14, 2020Inventors: Wilfried BRAJE, Katarina BRITZE, Justin D. DIETRICH, Anais JOLIT, Johannes KASCHEL, Johanna KLEE, Tanja LINDNER
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Publication number: 20200148611Abstract: The invention relates to a selective hydrogenolysis method for treating a feed rich in aromatic compounds having more than 8 carbon atoms, comprising transforming at least one alkyl group with at least two carbon atoms (ethyl, propyl, butyl, isopropyl, etc.) attached to a benzene ring into at least one methyl group. The invention also relates to the integration of the hydrogenolysis unit into an aromatic complex.Type: ApplicationFiled: July 16, 2018Publication date: May 14, 2020Applicant: IFP Energies NouvellesInventors: Alexandre PAGOT, Denis UZIO, Jean-Francois JOLY, Anne-Claire DUBREUIL
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Publication number: 20200148612Abstract: A process for the fluorination of a chlorinated C3 alkane or alkene compound having at least one chlorine atom into a fluorinated C3 alkane or alkene compound having at least one fluorine atom includes the following steps: a) contacting, in a reactor, the chlorinated compound with hydrogen fluoride in gas phase in the presence of a fluorination catalyst to produce a fluorinated compound, and b) regenerating the fluorination catalyst used in step a). The step (b) of regenerating the fluorination catalyst comprises (c) the treatment of said fluorination catalyst with an oxidizing agent-containing gas flow to form an oxidized fluorination catalyst, and (d) the treatment of the oxidized fluorination catalyst obtained in step (c) with a gaseous mixture comprising a reducing agent and an inert gas. The catalyst regenerated in step b) is reused in step a) and the reducing agent is selected from C1-C10 hydrohalocarbons.Type: ApplicationFiled: January 14, 2020Publication date: May 14, 2020Inventors: David Andre, Dominique Deur-Bert, Dominique Garrait, Anne Pigamo, Laurent Wendlinger
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Publication number: 20200148613Abstract: Certain embodiments of the invention provide a method of preparing a modified distilled alcoholic spirit, comprising contacting a corresponding starting distilled alcoholic spirit with a base under conditions that cause at least one free carbonyl compound in the starting distilled alcoholic spirit to be reduced, to provide the modified distilled alcoholic spirit that has at an alcohol by volume (ABV) of at least 15%. Certain embodiments also provide a modified distilled alcoholic spirit prepared by the methods described herein.Type: ApplicationFiled: July 25, 2019Publication date: May 14, 2020Applicant: Regents of the University of MinnesotaInventors: Devin Grant Peterson, Smaro Kokkinidou
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Publication number: 20200148614Abstract: A method of preparing bio-polyols from epoxidized fatty acid esters, wherein the bio-polyols are synthesized via hydroxylation with epoxidized fatty acid esters and ring-opening reagent, using the acidic ionic liquids as catalysts. The bio-polyols are used to synthesize bio-polyurethane and bio-polyurethane foams. The acidic ionic liquids in this process is used in esterification, epoxidation, and ring-opening reaction to synthesize bio-polyols. The ionic liquids catalysts have several advantages such as easy to separate, reusable, and may reduce pollution.Type: ApplicationFiled: October 24, 2019Publication date: May 14, 2020Inventors: You-Liang Tu, Ya-Shiuan Lin, Ming-Tsang Tsai, Chiu-Ping Li
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Publication number: 20200148615Abstract: A one-step process for hydroformylation of olefins can include iron-catalyzed hydroformylation of olefins. The process can result in the conversion of olefin in the range of 40 to 99%. A reaction mixture includes iron precursor, ligand, substrate and solvent. The reaction mixture can be pressurized with syngas (CO/H2) under constant stirring to obtain a desired aldehyde compound. The ligand can be a monodentate ligand of a phosphines or a phosphite, and the iron precursor can be [HFe(CO)4]?.Type: ApplicationFiled: April 27, 2018Publication date: May 14, 2020Inventors: Samir Hujur Chikkali, Swechchha Pandey
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Publication number: 20200148616Abstract: Provided herein are systems, and methods of using such systems, for producing acrylic acid from ethylene oxide and carbon monoxide on an industrial scale. The production system/production process has various unit operations, including, for example, a ?-propiolactone production system/production process configured to produce ?-propiolactone from ethylene oxide and carbon monoxide; a polypropiolactone production system/production process configured to produce polypropiolactone from ?-propiolactone; and a glacial acrylic acid production system/production process configured to produce acrylic acid with a high purity by thermolysis of polypropiolactone.Type: ApplicationFiled: January 10, 2020Publication date: May 14, 2020Inventors: Sadesh H. Sookraj, Jay J. Farmer
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Publication number: 20200148617Abstract: This present invention provides gemcabene pharmaceutically acceptable salts having a PSD90 of 35 ?m to about 90 ?m, methods for purifying crude gemcabene, pharmaceutically acceptable salts of purified gemcabene, pharmaceutical compositions of a gemcabene pharmaceutically acceptable salt and therapeutic and prophylactic methods useful for various conditions, including dyslipidemia.Type: ApplicationFiled: May 3, 2019Publication date: May 14, 2020Inventors: Daniela Carmen ONICIU, Charles Larry BISGAIER, José Rui GOMES, Stefan HECKHOFF
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Publication number: 20200148618Abstract: An active ester compound that can form a cured product having excellent dielectric properties and copper foil adhesion properties is provided, a curable composition including the active ester compound is provided, and a cured product of the curable composition is provided. Also provided are a semiconductor encapsulating material, a printed wiring board, and a build-up film formed by using the curable composition. Specifically, an active ester compound is provided which includes a fluorinated hydrocarbon structural moiety and a plurality of aromatic ester structural moieties in the structure of the molecule and includes an aryloxycarbonyl structure or an arylcarbonyloxy structure at an end of the molecule, a curable composition including the active ester compound, and a cured product of the curable composition, and also provided are a semiconductor encapsulation material, a printed wiring board, and a build-up film formed by using the curable composition.Type: ApplicationFiled: April 10, 2018Publication date: May 14, 2020Inventors: Tatsuya Okamoto, Yutaka Satou
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Publication number: 20200148619Abstract: A process for the transesterification of methyl-2-ethylhexanoate with triethylene glycol to produce triethylene glycol di-2-ethylhexanoate is provided. In the process, methyl-2-ethylhexanoate is combined with triethylene glycol to form a first mixture. The first mixture is heated in the presence of a catalyst to form a second mixture comprising methanol and triethylene glycol di-2-ethylhexanoate. Methanol is separated from the second mixture to yield triethylene glycol di-2-ethylhexanoate. Na2CO3, Cs2CO3, K2CO3, Rb2CO3, sodium methoxide or titanium isopropoxide are suitable catalysts.Type: ApplicationFiled: November 13, 2018Publication date: May 14, 2020Applicant: Eastman Chemical CompanyInventors: Sumit Chakraborty, Steven J. Adams, Robert Thomas Hembre, Scott Donald Barnicki, David Alan Jenkins
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Publication number: 20200148620Abstract: A method for preparing methyl methacrylate from methacrolein and methanol. The method comprises contacting in a reactor a mixture comprising methacrolein, methanol and oxygen with a heterogeneous catalyst comprising a support and a noble metal, wherein said catalyst has an average diameter of at least 200 microns, wherein oxygen concentration at a reactor outlet is from 0.5 to 7.5 mol % and wherein the reactor comprises a partition with the catalyst bed on a first side of the partition and with flow through the catalyst bed in a first direction and flow on a second side of the partition in an opposite direction.Type: ApplicationFiled: June 25, 2018Publication date: May 14, 2020Inventors: Kirk W. Limbach, Dmitry A. Krapchetov, Christopher D. Frick, Daniel A. Hickman
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Publication number: 20200148621Abstract: The invention relates to a process for preparing a carboxylic ester by reacting an aldehyde in the presence of an aluminum alkoxide, wherein the aluminum alkoxide is obtained either by reacting an aluminum hydride with an aldehyde or by reacting a different aluminum alkoxide with a carboxylic ester.Type: ApplicationFiled: May 14, 2018Publication date: May 14, 2020Applicant: EVONIK OPERATIONS GMBHInventors: Alexander LYGIN, Steffen KRILL, Matthias GRÖMPING, Andreas TEPPERIS
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Publication number: 20200148622Abstract: Disclosed is a mixture containing compound (I) and polymerizable compound (II) wherein compound (I) accounts for 50 mol % or more of the entire mixture and 1,4-cyclohexanedicarboxylic acid accounts for less than 5 mol % of the entire mixture; a method of producing the mixture which includes reacting in a water-immiscible organic solvent 1,4-cyclohexanedicarboxylic acid dichloride with compound (IV) in the presence of a base, and washing the obtained reaction solution with a weakly acidic buffer solution; etc. The disclosure provides mixtures useful for low-cost production of polymerizable compounds which have low melting points suitable for practical use, show superior solubility to general-purpose solvents, can be produced at low costs, and allow for provision of optical films capable of uniform polarized light conversion over a wide wavelength range, and methods of producing the mixtures. where A represents hydrogen, methyl group or chlorine, and n represents an integer of 1 to 20.Type: ApplicationFiled: January 16, 2020Publication date: May 14, 2020Applicant: ZEON CORPORATIONInventors: Kei SAKAMOTO, Kumi OKUYAMA, Kanako SANUKI
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Publication number: 20200148623Abstract: The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain.Type: ApplicationFiled: December 20, 2019Publication date: May 14, 2020Inventors: Michael Poulter, Tony Durst
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Publication number: 20200148624Abstract: The invention relates to a new process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly production of the said compounds. Thus, the present invention overcomes the disadvantages of the prior art processes, and in a surprisingly simple and beneficial manner, and as compared to the prior art processes, in particular, the invention provides a more efficient and energy saving processes, and also provides a more environmentally friendly process, for the manufacture of nuclear fluorinated aromatics, and preferably of nuclear fluorinated fluorobenzenes. Accordingly, in one aspect of the invention, an industrially beneficial process for preparing fluorobenzenes from halobenzene precursors using HF to form hydrogen halide is provided by the present invention.Type: ApplicationFiled: July 20, 2019Publication date: May 14, 2020Applicant: Fujian Yongjing Technology Co., Ltd.Inventors: Hongjun DU, Wenting WU
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Publication number: 20200148625Abstract: The invention relates to novel methods for preparing N-methyl-p-toluidine for the use thereof as additive for aviation fuel, and to specific catalysts for these methods.Type: ApplicationFiled: December 19, 2017Publication date: May 14, 2020Applicant: LANXESS DEUTSCHLAND GMBHInventors: Martina GERDINAND, Rainer DOST, Ralf KRAHWINKEL, Hans-Jurgen QUELLA, Daniel ULLRICH, Patrick KURR
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Publication number: 20200148626Abstract: The present invention relates to new crystalline forms of vilanterol trifenatate, processes for their preparation, and their use in a pharmaceutical composition for the treatment of respiratory diseases, particularly for the treatment of asthma and chronic obstructive pulmonary disease. In particular, the present invention relates to a crystalline form of vilanterol trifenatate characterised in that the form has an XRPD pattern as defined herein having characteristic diffraction angles (2-theta or 20(°)) falling within or at each end of one or more of the following ranges: (a) 3 to 5°, such as 3.8 to 4.4°; and/or (b) 7 to 9.9°, such as 7 to 8.5°; and/or (c) 12 to 13.3°, such as 12 to 13.3?; and/or (d) 16.4 to 17.3°, such as 16.4 to 17.3?; and/or (e) 26.8 to 28.3°, such as 26.8 to 28.3°.Type: ApplicationFiled: July 9, 2018Publication date: May 14, 2020Inventors: Nuno Torres LOURENÇO, Luis SOBRAL, Joana FERNANDES
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Publication number: 20200148627Abstract: The invention discloses a method for preparation of protected difluoromethylornithine by a difluoromethylation of dibenzaldimine ornithine ester using CHF3 and LiHMDS (lithium bis(trimethylsilyl)amide), which can be converted to a salt of unprotected difluoromethylornithine by a subsequent deprotection under acidic conditions in the presence of water.Type: ApplicationFiled: September 24, 2018Publication date: May 14, 2020Inventors: Bernhard GUTMANN, Michael BERSIER, Paul HANSELMANN, Christian Oliver KAPPE, Manuel KOECKINGER, Christopher HONE
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Publication number: 20200148628Abstract: The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.Type: ApplicationFiled: January 12, 2020Publication date: May 14, 2020Applicant: National Institute of Biological Sciences, BeijingInventors: Niu Huang, Shiming Peng
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Publication number: 20200148629Abstract: The present invention relates to a process for preparing an isocyanate by reacting a primary amine with phosgene, comprising I) providing an amine solution and adjusting its temperature in a heat exchanger, II) providing a phosgene solution and adjusting its temperature in a heat exchanger, III) mixing the amine solution with the phosgene solution in a mixing unit, followed by IV) further conversion in an adiabatically operated reaction zone and the removing of the gas phase formed as a result of the chemical reaction in a separation zone, V) expanding the remaining liquid phase, VI) further conversion of the liquid phase remaining after expansion in an indirectly heated reaction zone and VII) isolating the isocyanate from the reaction solution obtained therein, in which the temperature in the reaction zone and separation zone is adjusted by fixing a target value within a range from 110° C. to 145° C.Type: ApplicationFiled: November 8, 2019Publication date: May 14, 2020Inventors: Thomas Knauf, Christian Steffens, Anke Hielscher, Dietmar Wastian, Juergen Spriewald
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Publication number: 20200148630Abstract: The present invention relates to a process for preparing an isocyanate by reacting a primary amine with phosgene, comprising I) providing an amine solution, II) providing a phosgene solution, III) mixing the amine solution with the phosgene solution in a mixing unit, followed by IV) further conversion in an adiabatically operated reaction zone and the removing of the gas phase formed as a result of the chemical reaction in a separation zone, V) expanding the remaining liquid phase in two or three stages, VI) further conversion of the liquid phase remaining after the last expansion stage in an indirectly heated reaction zone and VII) isolating the isocyanate from the reaction solution obtained therein.Type: ApplicationFiled: November 8, 2019Publication date: May 14, 2020Inventors: Thomas Knauf, Juergen Spriewald, Anke Hielscher, Volker Michele, Dietmar Wastian, Christian Steffens
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Publication number: 20200148631Abstract: The present invention discloses a process for the synthesis of aromatic carbamates from amine with dialkyl carbonate in the presence of binary or ternary mixed metal oxide catalyst. The present invention further discloses the yield of said aromatic carbamate in the range of 60 to 99%. Further, the ratio of amine to dialkyl carbonate is in the range of 1:2 to 1:30.Type: ApplicationFiled: May 25, 2018Publication date: May 14, 2020Inventors: Ashutosh Anant KELKAR, Nayana Tushar NIVANGUNE, Vilas Hari RANE
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Publication number: 20200148632Abstract: Provided are embodiments of creatine and creatine ethyl ester (CEE) salts where the anion is an artificial (non-saccharide) taste-modifier. These compounds represent stable white non-hygroscopic solids or semisolids that can readily dissolve in water and buffer solutions. Synthesis of novel creatine salts using environmentally safe solvents such as ethanol resulted in the formation of products in quantitative yields with sodium or potassium chloride as a byproduct. The creatine and creatine alkyl eater derivative salts are stable sweet-tasting compounds that are more palatable to a consumer than creatine or derivatives thereof.Type: ApplicationFiled: May 7, 2018Publication date: May 14, 2020Inventors: Iryna Lebedyeva, Christopher Klug
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Publication number: 20200148633Abstract: A method for preparing hydrogen bis(fluorosulfonyl)imide including contacting sulfonyl fluoride with hexamethyl disilazane in an organic solvent. The disclosure also provides a method for preparing lithium bis(fluorosulfonyl)imide (LiFSI). The method includes contacting sulfonyl fluoride with hexamethyl disilazane in an organic solvent and yielding hydrogen bis(fluorosulfonyl)imide; and contacting hydrogen bis(fluorosulfonyl)imide with a lithium compound and yielding lithium bis(fluorosulfonyl)imide.Type: ApplicationFiled: January 16, 2020Publication date: May 14, 2020Inventors: Jingwei ZHAO, Yong XIN, Anle SUN, Chenglong ZHU, Lei XU
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Publication number: 20200148634Abstract: The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.Type: ApplicationFiled: November 8, 2019Publication date: May 14, 2020Inventors: Silvana Marcel Leit de Moradei, Eric Therrien
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Publication number: 20200148635Abstract: The present invention relates to 4-substituted amidine derivatives of the general formula (I), wherein A1-A4, D, L, Q, R7, R7? and integer's v and w have the meanings as defined in description. The invention further relates to methods for their preparation and use of said compounds to fight undesired phytopathogenic microorganisms, and agents for said purpose, comprising said amidine derivatives, all according to the invention. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted amidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention.Type: ApplicationFiled: May 17, 2018Publication date: May 14, 2020Applicant: PI INDUSTRIES LTD.Inventors: Maruti Naik, Vishal A. Mahajan, Manoj G. Kale, Sathiyamoorthi Sivakumar, Ankit Kumar Jain, Sulur G. Manjunatha, Santosh Shridhar Autkar, Ruchi Garg, Rupesh Kumar Mishra, Hagalavadi M. Venkatesha, Konstantin Poschnary, Alexander G.M. KLAUSENER
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Publication number: 20200148636Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.Type: ApplicationFiled: January 17, 2020Publication date: May 14, 2020Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
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Publication number: 20200148637Abstract: The present invention provides a production method of a 3-cyanopyrrole compound possibly useful as an intermediate for pharmaceutical products. A production method of compound (II) including subjecting compound (I) to a reduction reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. A production method of compound (III) including subjecting compound (I) to a reduction reaction followed by a cyclization reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst.Type: ApplicationFiled: January 10, 2020Publication date: May 14, 2020Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: TAKASHI OUCHI, GIHO GOH, SUNMI KIM, JINSOON CHOI, HUNSOO PARK
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Publication number: 20200148638Abstract: Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders associated with mast cells. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more diseases and disorders associated with mast cells.Type: ApplicationFiled: January 9, 2020Publication date: May 14, 2020Inventors: Lijun Sun, Aristidis Veves
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Publication number: 20200148639Abstract: A compound is represented by a formula (1) below, in which k is an integer of 0 or more, m is an integer of 1 or more, n is an integer of 2 or more. L is a substituted or unsubstituted aromatic hydrocarbon ring having 6 to 30 ring carbon atoms, CN is a cyano group, and D1 and D2 are each independently represented by one of a formula (2), a formula (3) and formula (3x) below, D1 and D2 being optionally mutually the same or different.Type: ApplicationFiled: January 10, 2020Publication date: May 14, 2020Applicant: Idemitsu Kosan Co., Ltd.Inventors: Satomi Tasaki, Masahiro Kawamura, Toshinari Ogiwara, Hitoshi Kuma, Kei Yoshida, Keiji Okinaka
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Publication number: 20200148640Abstract: To provide a light-emitting element having high luminous efficiency and to provide a light-emitting device and an electronic device which consumes low power and is driven at low voltage, a carbazole derivative represented by the general formula (1) is provided. In the formula, ?1, ?2, ?3, and ?1 each represent an azylene stoup having less than or equal to 13 carbon atoms; Ar1 and Ar2 each represent an aryl group having less than or equal to 13 carbon atoms; R1 represents any of a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a substituted or unsubstituted phenyl group, and a substituted or unsubstituted biphenyl group; and R2 represents any of an alkyl group having 1 to 6 carbon atoms, a substituted or unsubstituted phenyl group, and a substituted or unsubstituted biphenyl group. In addition, l, m, and n are each independently 0 or 1.Type: ApplicationFiled: January 14, 2020Publication date: May 14, 2020Applicant: SEMICONDUCTOR ENERGY LABORATORY CO., LTD.Inventors: Hiroko NOMURA, Harue OSAKA, Takahiro USHIKUBO, Sachiko KAWAKAMI, Satoshi SEO, Satoko SHITAGAKI
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Publication number: 20200148641Abstract: The invention relates to novel N-(?-peroxy)carbazole compounds of Formula I and methods for use. The N-(?-peroxy)carbazole compounds described herein are useful for treating or preventing parasitic infections, bacterial infections, and cancer in subjects. The methods include administering an N-(?-peroxy)carbazole compound as described herein to a subject. Also described herein are methods for synthesizing N-(?-peroxy)carbazole compounds.Type: ApplicationFiled: January 20, 2020Publication date: May 14, 2020Inventors: Xinbo WANG, Zhiping LAI, Yupeng PAN, Kuowei HUANG
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Publication number: 20200148642Abstract: The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: November 8, 2019Publication date: May 14, 2020Applicant: Cortexyme, Inc.Inventors: Andrei W. Konradi, Robert A. Galemmo, JR., Casey C. Lynch
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Publication number: 20200148643Abstract: The invention relates to new compounds with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.Type: ApplicationFiled: January 10, 2020Publication date: May 14, 2020Inventors: Yun YEN, Jing-ping LIOU, Shiow-lin PAN
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Publication number: 20200148644Abstract: The present invention is directed to new crystalline forms of Pitavastatin hemicalcium salt, referred to hereinafter as polymorphic Forms A, B, C, D, E and F, as well as the amorphous form. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and the amorphous form and pharmaceutical compositions comprising these crystalline forms or the amorphous forms.Type: ApplicationFiled: January 13, 2020Publication date: May 14, 2020Applicant: NISSAN CHEMICAL CORPORATIONInventors: Paul Adriaan VAN DER SCHAAF, Fritz BLATTER, Martin SZELAGIEWICZ, Kai-Uwe SCHOENING
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Publication number: 20200148645Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.Type: ApplicationFiled: January 13, 2020Publication date: May 14, 2020Inventors: Binghui Shen, Judith Campbell, Li Zheng, Hongzhi Li, David Horne, Jun Xie, Kenneth Karanja