Abstract: An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

Abstract: A device and method for spectrum analysis in which differences among skin spectra are quantitatively analyzed, and a blood glucose measurement device are provided. The device for spectrum analysis includes an obtainer configured to acquire a plurality of skin spectra; and a processor configured to generate a plot of difference degree of spectra which represents differences among the acquired plurality of skin spectra, and determine whether the plurality of skin spectra are appropriate for blood glucose measurement based on the plot of difference degree of spectra.

Abstract: Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges.

Abstract: Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: A method of monitoring a subject for the risk of Acute Mountain Sickness (AMS) includes obtaining real-time pulse arterial oxygen saturation (SpO2) measurements from the subject. The SpO2 measurements are transformed into a novel metric known as Accumulated Hypoxic Debt (AHD). The AHD metric is used as the independent variable in a longitudinal generalized linear mixed model to calculate the probability D that the subject is at risk of AMS. Based on the probability D, appropriate courses of action may be communicated to the subject via the output device of a wearable or portable monitor.

Abstract: A sensor may include a light source, a light detector, and a housing. The housing may have a first upper side and extend from the first upper side, a first cavity and a second cavity. The light detector is arranged in the first cavity. The light source is arranged in the second cavity. A strut may be arranged between the first cavity and the second cavity and is made from a material that absorbs or reflects light. A first cover may be mounted above the first cavity and comprises a deflection region and a plane of incidence. The deflection region is designed such that 80% of the light which is incident in the deflection region on the plane of incidence of the first cover from a predetermined direction and which is incident on the light detector, is directed away from the light detector based on an optical element.

Abstract: A specimen transfer device adapted to receive a blood sample is disclosed. The specimen transfer device includes a housing and an actuation member. A deformable material is disposed within the housing and is deformable from an initial position in which the material is adapted to hold the sample to a deformed position in which at least a portion of the sample is released from the material. A viscoelastic member is disposed within the housing between the material and the housing and between the material and the actuation member. The viscoelastic member is engaged with the actuation member and the material such that movement of the actuation member from a first position to a second position deforms the material from the initial position to the deformed position.

Abstract: A safety catheter insertion assembly including a catheter hub coupling assembly. The safety catheter insertion assembly having a needle hub slideably coupled to a needle housing such that the needle hub is moveable between a first position wherein an insertion needle extends from the needle housing, and a second position wherein the sharp distal tip is housed within the needle housing, the catheter hub coupling assembly coupling the catheter hub to the needle housing in the first position and releasing the catheter hub from the needle housing in the second position.

Abstract: Bodily fluid withdrawing devices including electronics, and associated systems and methods, are disclosed. In some embodiments, the devices include a housing containing a bodily fluid withdrawing feature, an actuator movable relative to the housing, and one or more electronic component(s). The electronic component(s) can be configured to transition from an inactive state to an active state when the device is actuated and a circuit of the device is closed. Upon transitioning to the active state, the electronic component(s) can be configured to wirelessly transmit information and/or receive information from an external recipient. In some embodiments, the devices disclosed herein can comprise part of an interconnected system including one or more communication devices.

Abstract: An apparatus and method for monitoring a vehicle driver having at least one sensor for measuring pressure and/or humidity. The sensor includes at least one capacitor having at least two electrodes, which may be arranged horizontally on a flexible support material. At least one dielectric layer may be arranged between the electrodes. At least one electrode, and/or the dielectric layer, and at least one, at least partially liquid-permeable and/or liquid-absorbing moisture layer may be arranged on a side facing away from a support material. At least one electrode and/or the dielectric layer may be arranged transversely between the support material and the moisture layer. A capacitance may be changed by liquid on the dielectric layer, and a processing unit measures and/or stores values from the sensor, creating a capacitive humidity sensor. The processing unit may send the to a central CPU, wherein this data may be processed by the processing unit.

Abstract: Systems and methods are provided for providing a standardized pressure value representing a transient pressure event within a region of interest within a living body. An air-charged catheter is configured to record pressure data representing the region of interest. A measurement assembly includes a parameter calculation component configured to calculate at least a peak pressure representing the transient pressure event and a time to peak pressure, representing the time necessary to reach the peak pressure, from the recorded pressure data. A standardization component is configured to calculate the standardized pressure value as a function of the peak pressure and the time to peak pressure. A user interface is configured to display at least the standardized pressure value at an associated display.

Abstract: Various embodiments are directed to systems and methods for evaluating jaw movement characteristics of a user, for example, in a plurality of distinct jaw motion directions. In an example implementation, a jaw exercise system as discussed herein is configured to facilitate the exercise and/or quantification of a user's jaw strength in at least one of six distinct directions. As described herein, the jaw exercise system may comprise a frame assembly to which a user may selectively attach one of a plurality of an interchangeable functional assemblies, each configured to facilitate the evaluation of the jaw movement characteristics of a user in six jaw movement directions. The jaw exercise system comprises one or more of a progressive resistance attachment assembly, a passive motion attachment assembly, a force characterization attachment assembly, and a hyoid motion attachment assembly.

Abstract: An intracellular monitoring device (IMD) that fits completely inside a living cell, and causes no significant impairment, to a cell's normal biological processes. The IMD monitors a cell for its level of a biological substance (e.g., calcium ion concentration) of interest. If the biological substance reaches or exceeds a threshold, the IMD transmits an electromagnetic signal, received by an antenna outside the cell. Each IMD has its electromagnetic signal encoded with a unique frequency. Detection of the frequency components, in the signals received by an antenna, permits identification of the source IMD's. A high calcium ion concentration is indicative of a strongly-activated cerebral cortex neuron. Brain tissue is relatively transparent to near infrared, making it a good frequency band, for the electromagnetic signals from neuron-monitoring IMD's. The near infrared of each IMD can be produced by quantum dots, powered by bioelectric catalysis triggered by high calcium ion concentration.

Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.

Abstract: A biosensor includes an optical sensor circuit that emits light directed at skin tissue of a patient at a plurality of wavelengths. A first and second spectral response of light reflected from the tissue is obtained around a first wavelength in a UV range and a second wavelength in an IR range. A measurement of a substance in blood flow is then determined from the spectral responses. A risk of a health condition is obtained using the measurement. The health condition may include one or more of hyperglycemia, diabetes or hypoglycemia.

Abstract: The present invention relates to a system, method and corresponding computer program for milk ejection reflex (MER) determination, the system comprising a breast shield arrangement (1) for a breast pump (2) configured to be attached on a first breast of a female, a physiological sensor unit (4) for receiving a physiological reception signal from the second breast, which is opposite to the first breast, wherein the physiological reception signal is indicative of fluid contents in the second breast, and wherein the system is configured to determine a milk ejection reflex based on a change in fluid contents in the second breast. It finds particular application during and in connection with breastfeeding and allows for direct detection of the beginning of the milk flow in the breast, i.e. the occurrence of the MER, without delay and with a high degree of precision.

Abstract: Devices, systems and methods are described herein that enable and make assessments related to pregnancy, including assessments related to a labor-related status such as the onset of true labor. In some embodiments, a pregnancy monitoring system comprises a portable, noninvasive data acquisition device adhered to a patient's skin, comprising at least two electrodes to measure uterine electrical activity, signal processing means, data storage means, and a battery. Systems for notification of the labor-related status are described.

Abstract: Provided herein are MD Codes, MD DYNA Codes, MD ASA, and Next Human system, and the methods of using them to diagnose and treat aesthetic conditions or disorders.

Abstract: Methods of patient-specific modeling of the mechanical properties of bone and related systems. The methods include obtaining a bending stiffness (K) of a bone specimen non-invasively and non-destructively in a dynamic 3-point bending test, creating a mathematical mechanical model of the bone specimen, assigning an elastic modulus (E) to the bone specimen of the mathematical mechanical model, determining the flexural rigidity of the bone specimen from simulating the mathematical mechanical model, determining a discrepancy between the flexural rigidity of the bone specimen from the simulated mechanical model and based on the obtained K, adjusting the elastic modulus of the simulated mechanical model to minimize the discrepancy, adjusting the elastic modulus until an optimized elastic modulus is determined where the discrepancy is reduced below a predetermined threshold, and applying the optimized elastic modulus to the simulated mechanical model to determine a strength of the bone.

Abstract: A muscle mass estimation method including acquiring a height of a living organism, acquiring an electrical resistance value measured for the living organism, and computing a muscle mass of the living organism using a calculation formula including a first variable including the height of the living organism and the electrical resistance value, and a second variable including the electrical resistance value.

Abstract: The invention relates to a device comprising a detection unit (1) for the position and orientation of a first limb of a user (3) and a display device (4) for displaying a second limb (5).

Abstract: A system (400) for monitoring an individual's sleep includes: (i) a patient monitor (410) configured to obtain a patient waveform, the patient waveform comprising information representative of a vital statistic of the patient; a processor (420) in communication with the patient monitor and configured to: (i) process the patient waveform to generate a segmented waveform; (ii) extract at least one feature from a segment of the waveform in a time domain and/or at least one feature from the segment of the waveform in the frequency domain; (iii) classify, using the at least one extracted feature, a sleep stage of the patient for the segment of the waveform; and (iv) generate, from classified sleep stages for a plurality of segments of the waveform, a sleep quality measurement; and a user interface (480) configured to report the generated sleep quality measurement.

Abstract: A system and method for automatically implementing a therapy for treating sleep disordered breathing.

Abstract: A method to determine medication adherence may include detecting whether a wearable electronic device is in use. The method may include detecting one or more markers in sweat vapor of the user using a chemical marker sensor of the wearable electronic device. The method may include, in response to detecting that the system is in use, determining whether the user has taken a therapeutic agent that includes the one or more markers based on detecting the one or more markers in the sweat vapor.

Abstract: In various exemplary embodiments systems and methods for determining an efficacy of a cosmetic skin treatment are provided. In an exemplary embodiment, a system for determining an efficacy of a cosmetic skin treatment comprises: a sensor configured to determine a skin ageing information item of a user and a memory configured to store the skin ageing information item of the user determined by the sensor. A processor is configured to determine an objective skin treatment success of the user on the basis of a comparison of the skin ageing information item of the user measured by the sensor with a stored skin ageing information item stored in the memory.

Abstract: Embodiments are disclosed for health assessment and diagnosis implemented in an artificial intelligence (AI) system. In an embodiment, a method comprises: capturing, using one or more sensors of a device, signals including information about a user's symptoms; using one or more processors of the device to: collect other data correlative of symptoms experienced by the user; and implement pre-trained data driven methods to: determine one or more symptoms of the user; determine a disease or disease state of the user based on the determined one or more symptoms; determine a medication effectiveness in suppressing at least one determined symptom or improving the determined disease state of the user; and present, using an output device, one or more evidence for at least one of the determined symptoms, the disease, disease state, or an indication of the medication effectiveness for the user.

Abstract: The present invention discloses methods and apparatus for fostering wireless communication to and from orthopedic implants. Cuff and bandage devices provide a means of supporting a device which coordinates and optimizes communication with orthopedic implants. The devices support methods which can provide feedback to a user to optimize the signal strength and signal to noise aspects of wireless connections to and from orthopedic implants.

Abstract: The present disclosure relates to a wrist strap (10) for a biometric monitor, wherein the biometric monitor comprises a casing (12) having a first surface (14) and a second surface (16) opposite to the first surface, the second surface comprising a biometric sensor area (18) located at the centre area of the second surface, said strap comprising receiving means arranged to receive the biometric monitor, such that the biometric monitor is attachable to the strap via a pair of parts (20, 21; 22, 23; 24, 25) enabling rotational movement of the biometric monitor, the parts being located at two opposite perimeter side edges of the biometric monitor, and thereby defining a rotation axis (Ax1), wherein the perpendicular bisector (PB1) of the rotation axis (Ax1) between the pair of parts is arranged to pass through the centre area of the second surface. The present disclosure also provides a biometric monitor connected to the wrist strap.

Abstract: Example blood pressure apparatus using active materials and related methods are described herein. An example apparatus includes a band to be worn around a limb of a user, an active material carried by the band and a controller to: (1) apply an activation signal to the active material to constrict blood flow in the limb, and (2) reduce the activation signal to allow blood flow in the limb.

Abstract: A bra for measuring a physiological signal from a body of a user wearing the bra comprises first and second front portions, or bra cups portions. The bra also comprises first and second side wings, wherein the first side wing is coupled with the first front portion and the second side wing is coupled with the second front portion. In addition the bra comprises a measuring device and/or at least two electrodes, where the measuring device or at least one electrode is arranged to a module, and the module forms at least a basis of the first side wing of the bra or even the first side wing of the bra as its entirety.

Abstract: A patient monitor can noninvasively measure a physiological parameter using sensor data from a nose sensor configured to be secured to a nose of the patient. The nose sensor can include an emitter and a diffuser. The diffuser is configured to generate a signal when detecting light attenuated by the nose tissue of the patient. An output measurement of the physiological parameter can be determined based on the signals generated by the diffuser.

Abstract: A wearing prompt method for a wearable device and an apparatus, and related to the field of communications technologies, to reduce a probability that the wearable device cannot accurately measure physiological parameters of a user, thereby improving accuracy of measuring the physiological parameters of the user. The method includes: obtaining, by the wearable device, a target PPG (photo plethysmo graph) signal; and prompting, by the wearable device when the target PPG signal is inconsistent with a stored reference wearing parameter, a user to adjust a wearing position of the wearable device and to adjust tightness of wearing the wearable device.

Abstract: An electronic device may include: a housing; a display configured to be viewed through a first portion of the housing; a photoplethysmogram sensor exposed through a second portion of the housing and configured to measure a biometric signal from a body part of a user while being in contact with the body part of the user; a fastening structure connected to the housing and configured to be attached to the body part of the user; a wireless communication circuit; a processor provided inside the housing and operatively connected to the display, the photoplethysmogram sensor, and the wireless communication circuit; and a memory operatively connected to the processor. The memory stores instructions, when executed, to allow the processor to: receive data from the photoplethysmogram sensor; determine a first parameter; determine a distance between the body part of the user and the fastening structure; and provide user guidance information on the display.

Abstract: A bioelectrical signal measuring apparatus includes a mucosa contact electrode brought into contact with a nasal cavity mucosa or an oral cavity mucosa to apply a negative pressure and to measure a bioelectrical signal, an insertion tube, having one end supporting the mucosa contact electrode, inserted into a nasal cavity and bent, and a lead wire, connected to the mucosa contact electrode and connected to an amplifier disposed outside, extending in the insertion tube.

Abstract: Various embodiments of the present disclosure include a consumable capsule containing an active ingredient in at least one compartment movably sealed by a stimuli responsive actuator, and an activation device configured to communicate with the consumable capsule. The activation device is configured to emit a wireless signal to activate the stimuli responsive actuator of the consumable capsule, and the consumable capsule is configured to release the active ingredient into an external environment based on the activation of the stimuli responsive actuator.

Abstract: Methods and systems are provided for obtaining cleaned sequences showing trajectories of movement of a center of gravity and for estimating a biometric information pattern or value of a target. One of the methods includes removing noises from initial sequences showing trajectories of movement of a center of gravity to obtain the cleaned sequences. Another one of the methods includes reading cleaned sequences of the target into a memory, extracting features from the cleaned sequences, and estimating a biometric information pattern or value of the target from the extracted features, using a classification or regression model of biometric information patterns or values. The biometric information pattern may be a pattern derived from respiratory or circulatory organs of a target.

Abstract: Methods comprising applying a first analyte point measurement filter comprising: receiving, from an in vivo analyte sensor, at least a first, second, and third uncompensated analyte measurement at a first, second and third reference time; determining a first scaled rate-of-change by multiplying a first weighting coefficient and a first rate-of-change, the first rate-of-change computed between the first uncompensated analyte measurement at the first initial reference time to the second uncompensated analyte measurement at the first prior reference time; determining a second scaled rate-of-change by multiplying a second weighting coefficient and a second rate-of-change, the second rate-of-change computed between the first uncompensated analyte measurement at the first initial reference time to the third uncompensated analyte measurement at the second prior reference time; and calculating a first filter lag-compensated point measurement based on the sum of the first uncompensated analyte measurement, the first s

Abstract: A method is provided. The method includes acquiring simultaneously multiple magnetic resonance (MR) images and multiple ultrasound images of an anatomical region of a subject over a scanned duration. The method also includes training an unsupervised deep learning-based deformable registration network. This training includes training a MR registration subnetwork based on the multiple MR images to generate MR deformation and transformation vectors, training an ultrasound registration subnetwork based on the multiple ultrasound images to generate ultrasound deformation and transformation vectors, and training a MR-to-ultrasound subnetwork based the multiple MR images and the multiple ultrasound images to generate MR-to-ultrasound deformation and transformation vectors between corresponding pairs of MR images and ultrasound images at each time point.

Abstract: An example autoregulation monitoring system includes processing circuitry configured to receive a blood pressure signal indicative of a blood pressure of a patient; determine a derivative of at least a portion of the blood pressure signal; determine, based on the derivative, a characteristic arterial pressure (CAP) value; determine, based on the CAP value, an autoregulation value of the patient; and output a signal indicative of the autoregulation value of the patient.

Abstract: Devices, systems, and methods for visually depicting a vessel and evaluating treatment options are disclosed. The methods can include obtaining proximal pressure measurements from a proximal pressure sensing component positioned within a vessel of a patient; obtaining distal pressure measurements from multiple pressure sensing components positioned within the vessel of the patient, wherein the multiple pressure sensing components are positioned distal of the proximal pressure sensing component and are spaced along a length of the vessel; and outputting a screen display having a visual representation of the proximal and distal pressure measurements.

Abstract: A system and method for monitoring a medical procedure performed in a clinical environment is provided. An audio recorder is configured to produce a verbal data signal that is representative of a verbal communication occurring in the clinical environment, and a data analyzer is configured to detect an adverse condition based upon the verbal data signal. An alert module is configured to alert an operator upon the detection of an adverse condition.

Abstract: An apparatus having at least one anatomical support member which comprises at least one layer of laminar sheeting and at least one articulating joint unit is in engagement with the at least one of anatomical support member. The joint is positionable in at least a vertical and horizontal orientations enabling smooth positioning of portions of an anatomy in three dimensions such that translational and/or rotational centrepoints in its x, y and z axes substantially coincide. The joint is preferably made of by material(s) that do not cause substantial radiographic or nuclear imaging artifacts when medically imaged thereby.

Abstract: A self-shielded and computer controlled system for performing non-invasive stereotactic radiosurgery and precision radiotherapy using a linear accelerator mounted within a two degree-of-freedom radiation shield coupled to a three-degree of freedom patient table is provided. The radiation shield can include an axial shield rotatable about an axial axis and an oblique shield independently rotatable about an oblique axis, thereby providing improved range of trajectories of the therapeutic and diagnostic radiation beams. Such shields can be balanced about their respective axes of rotation and about a common support structure to facilitate ease of movement. Such systems can further include an imaging system to accurately deliver radiation to the treatment target and automatically make corrections needed to maintain the anatomical target at the system isocenter.

Abstract: A medical imaging system includes a first collimator configured to filter radiation emitted from a subject, a first detector configured to detect radiation that has passed through the first collimator, a second collimator configured to filter radiation emitted from the subject, wherein the first collimator partially blocks a field of view (FOV) of the second collimator, and a second detector configured to detect radiation that has passed through the second collimator.

Abstract: An imaging device including a gantry defining an analysis zone and a circular trajectory of extension extending around a central axis. The gantry includes an acquisition unit having at least a detector suitable to receive said radiation after said radiation has passed through the analysis zone, and a casing defining a housing volume for the detector and including a curved base module and a curved mobile module movable relative to the curved base module so as to vary the angular extension of the casing. A carriage is housed in the housing volume to which the image acquisition unit is attached. There is a base guideway integral with the curved base module defining a base sliding trajectory for the carriage in the curved base module, and a mobile guideway integral with and inside the curved mobile module and defining a mobile sliding trajectory for the carriage in the curved mobile module.

Abstract: A portable radiation imaging apparatus including: a detection section which includes a plurality of radiation detection elements for accumulating electric charges corresponding to a radiation amount, the radiation detection elements being two-dimensionally arranged; and a control section which controls accumulation of the electric charges in the radiation detection elements and reading of the accumulated electric charges from the radiation detection elements and generates a plurality of frame images of a subject, the electric charges to be accumulated corresponding to the radiation amount of radiation emitted in a pulsed manner by a radiation source and transmitted through the subject, wherein the control section adjusts a synchronization timing between the radiation source and the detection section by using a waveform of radiation emitted by the radiation source, the waveform being obtained by reading electric charges from at least a part of the plurality of radiation detection elements.

Abstract: A multi-mode system and method for imaging a patient's breast with x-rays in one or more of a CT mode, a narrow-angle tomosynthesis mode, a wide angle tomosynthesis mode, and a mammography mode, using essentially the same equipment, on one or more compressions or immobilizations of the breast.

Abstract: A mammography apparatus includes a radiation source driver that moves a radiation source to a plurality of imaging positions including a first imaging position where LE imaging of emitting radiation R with low energy from the radiation source to capture a radiation image is performed, and a second imaging position where the LE imaging and HE imaging of emitting radiation R with high energy to capture a radiation image are performed, and a controller that causes a radiation detector to perform the LE imaging at the first imaging position in a state where the radiation source is moved, and causes the radiation detector to perform the LE imaging and the HE imaging at the second imaging position in a state where the movement of the radiation source is stopped or the radiation source is moved at a moving speed slower than that at the first imaging position.