Abstract: Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics.

Abstract: The invention relates to new bispecific antigen binding molecules, comprising at least one antigen binding domain capable of specific binding to 4-1BB, at least one moiety capable of specific binding to a target cell antigen, and a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP) comprising FAP clone 212 or variants thereof, and (b) at least one antigen binding domain capable of specific binding to CD40, and to methods of producing these molecules and to methods of using the same.

Abstract: The present invention provides a bispecific polypeptides, such as bispecific antibodies, comprising a first binding domain capable of specifically binding to a first T cell target, and a second binding domain capable of specifically binding to a second T cell target, wherein the first and second T cell targets are different targets. The invention further provides compositions of said bispecific polypeptides, as well as methods and uses of the same.

Abstract: The present disclosure provides antibodies that bind to human CD38. In particular, the antibodies and antigen-binding portions thereof are defined by particular functional characteristics. The antibodies present features compatible for manufacturing and can be provided as fully human antibodies (e.g., fully human monoclonal antibodies or antigen-binding fragments) that can be useful for medical methods and compositions, in particular for treating cancer.

Abstract: Use of the extracellular loop 1 (ECL 1) of TM4SF1 as a target for cancer treatment. More specifically, specific binding of antibodies of the ECL1 of TM4SF1 and peptides of ECL1.

Abstract: Disclosed herein are methods and agents for the treatment of cancer using p53-independent apoptosis to reduce the number of p53-depleted or p53-mutated cancer cells that have amplified HER2 gene. Also disclosed herein are methods and agents for the treatment of HER2-positive cancer in individuals with Li-Fraumeni Syndrome.

Abstract: The present invention generally relates to antibodies that bind to STEAP-1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: A Twin Immune Cell Engager (TWICE) is a kit or composition for treating cancer comprising a first component and second component. Each component comprises a targeting moiety that binds a tumor antigen expressed by the cancer or an antigen expressed by a non-cancer cell in the tumor microenvironment. In some embodiments, the first and second components each comprise an immune cell binding domain capable of immune cell binding activity when binding the immune cell binding domain in the other component, and a complementary binding domain capable of binding to a complementary antigen when binding the complementary binding domain in the other component. In some embodiments, the first and/or second components comprise a complementary functional domain with activity when targeted to the cancer cell or its microenvironment. The present TWICE complexes offer a unique ability to combine multiple functions into a two-component complex that becomes activated in the tumor microenvironment.

Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: The present invention relates to immunoglobulins that specifically bind MMP13 and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit an activity of MMP13 and preferably are also stable.

Abstract: Polypeptides are provided that are capable of significantly inhibiting and/or neutralizing P. aeruginosa. The polypeptides comprise two or more immunoglobulin single variable domains that are directed against the PcrV protein of P. aeruginosa, wherein the “first” immunoglobulin single variable domain and the “second” immunoglobulin single variable domain have different paratopes.

Abstract: The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents, comprising engineered immunoglobulin alleles. Mutations in the alleles are designed to compromise allelic exclusion and have potential to be exploited for the isolation of bispecific antibodies.

Abstract: The present invention provides a method for suppressing non-specific binding of a binding protein to a surface molecule of eukaryotic cell membrane or exosome, including immobilizing the binding protein on a carrier in the presence of gelatin.

Abstract: Circular handed alpha-helical repeat proteins are described. The repeat proteins have a number of uses as scaffolds for geometrically precise, arrayed presentation of cell-signaling or immune-related protein and peptide epitopes, as well as numerous other therapeutic, diagnostic, and nanotechnological uses.

Abstract: A sulfated cellulose fiber having a cellulose I crystal structure is provided. A chemically modified cellulose fiber which has a cellulose I crystal and in which some hydroxyl groups of cellulose are substituted with a substituent represented by formula (1). An amount of the substituent introduced is 0.1 mmol to 3.0 mmol per 1 g of the chemically modified cellulose fiber, and an average degree of polymerization is 350 or more. (In formula (1), M represents a monovalent to trivalent cation.) In the production of the chemically modified cellulose fiber, a cellulose fiber is treated with sulfamic acid while maintaining a cellulose fiber shape to allow sulfamic acid and a cellulose fine fiber which is a constituent of the cellulose fiber to react with each other.

Abstract: Degraded hydroxyalkylated starches and methods of preparing the same from waxy, normal, or modified starches are provided. The starches can be prepared by several approaches that involve acid or enzyme degrading either before or after starch modification with an alkylene oxide. The modified and degraded starches exhibit improved swelling characteristics, solution stability of cooked starch, improved film-forming properties and/or improved coating performance. In addition, the degraded hydroxyalkylated starches can be used as a fat replacement in foods, in film-forming compositions, in coating compositions, and to encapsulate other materials.

Abstract: Described herein is a flowable suspension comprising about 10-60 wt % of beta glucan with desirable swelling and dispersion properties.

Abstract: A glycosaminoglycan derivative endowed with heparanase inhibitory activity and antitumor activity, bearing carboxylate groups in positions 2 and 3 of at least part of the glycosaminoglycan residues, and to the process for preparing the same. The glycosaminoglycan derivatives of the present invention are generated starting from natural or synthetic glycosaminoglycans, preferably heparin or low molecular weight heparin, optionally 2-O- and 2-N-desulfated by two steps of oxidation. By the first oxidation, adjacent dials and optionally adjacent OH/NH2 of the glycosaminoglycan residues are converted to aldehydes and by the second oxidation said dialdehydes are converted to carboxylate groups. The first oxidation preferably leads to the cleavage of C2-C3 linkage of the ring of oxidable residues. The invention relates to a process for the preparation of said glycosaminoglycan derivatives and to their use as active ingredients of medicaments.

Abstract: Polyhydric polymers may be converted to derivatives thereof by reaction with divinyl sulfone to provide vinyl sulfone substituted polymers, where the polymers may additionally be further derivatized, including crosslinked, and the crosslinked and non-crosslinked derivatives may be used in biomedical and other applications.

Abstract: Disclosed are compositions comprising a liquid carrier, a polysulfide rubber curing agent, a metal cation, and an ionic liquid. Also disclosed are methods for curing a surface of an uncured polysulfide rubber. These methods involve applying the disclosed compositions to the surface of the uncured polysulfide rubber.

Abstract: Catalyst deactivating agents and compositions containing catalyst deactivating agents are disclosed. These catalyst deactivating agents can be used in methods of controlling polymerization reactions, methods of terminating polymerization reactions, methods of operating polymerization reactors, and methods of transitioning between catalyst systems.

Abstract: Embodiments are directed to a catalyst system comprising metal ligand complexes and processes for polyolefin polymerization using the metal ligand complex having the following structure:

Abstract: The present invention relates to a solid Ziegler-Natta catalyst component comprising transition metal compound of Group 4 to 6, and a polymeric nitrogen containing electron donor, preferably selected from linear or branched polyalkyleneimines or isomers or mixtures therefrom. The invention relates further to the use of said polymeric internal electron donor in a solid Ziegler-Natta catalyst component, a catalyst comprising said solid Ziegler-Natta catalyst component and a cocatalyst, and use of said catalyst in producing C2 to C6 olefin (co)polymers.

Abstract: The present invention generally relates to processes for converting an ester group to an acid group for polymers having a pendant ester of an acid group. This process is generally performed using an aqueous strong base.

Abstract: A flame retardant with which fire retardancy is improved and the fire retardancy is able to be secured stably for a long time is provided. An internal layer 11 containing a polymer and a flame retardant factor layer 12 that is formed outside of the internal layer 11 and that contains a polymer to which at least one of a sulfonate group and a sulfonate base is bonded are included. Thereby, compared to a case that the flame retardant factor layer 12 is not included, moisture is hardly absorbed, and respective particles of the flame retardant are inhibited from being adhered to each other. Accordingly, blocking is inhibited.

Abstract: A flame retardant with which fire retardancy is improved and the fire retardancy is able to be secured stably for a long time is provided. An internal layer 11 containing a polymer and a flame retardant factor layer 12 that is formed outside of the internal layer 11 and that contains a polymer to which at least one of a sulfonate group and a sulfonate base is bonded are included. Thereby, compared to a case that the flame retardant factor layer 12 is not included, moisture is hardly absorbed, and respective particles of the flame retardant are inhibited from being adhered to each other. Accordingly, blocking is inhibited.

Abstract: A fluorosulfonyl group-containing polymer having units represented by the following formula u1, a sulfonic acid group-containing polymer having fluorosulfonyl groups in the fluorosulfonyl group-containing polymer converted into sulfonic acid groups, its production method and its applications: wherein RF1 and RF2 are a C1-3 perfluoroalkylene group.

Abstract: [Object] To provide a method for producing a vinyl ether polymer containing an oxyethylene chain in a stable and efficient manner, wherein decomposition of the monomer and generation of polyacetal are suppressed. [Means for solving problem] The method for producing a vinyl ether polymer containing an oxyethylene chain according to the present invention comprises the step of polymerizing vinyl ether represented by the following formula (1): wherein R1 represents an alkyl group having 1 to 3 carbons, and n represents an integer from 1 to 10, in the presence of water as a polymerization solvent, a basic compound as an additive, and an organic azo-based compound as a radical polymerization initiator, and in pH of 5 or more.

Abstract: The present invention is directed at the decarboxylation and amidation of polyitaconic acid polymers. The polymers formed have useful dispersion properties and are suitable for use in the prevention of scaling.

Abstract: The present disclosure relates to poly(alpha-olefin)s and methods for making poly(alpha-olefin)s. A poly(alpha-olefin) may include about 95 wt % or greater C10-C18 alpha-olefin content and have a weight average molecular weight of from about 1,000,000 g/mol to about 10,000,000 g/mol. A method for forming a poly(alpha-olefin) may include introducing one or more C10-C18 alpha-olefins to a catalyst system comprising a catalyst compound and an activator. The method may include obtaining poly(alpha-olefin)s comprising about 95 wt % or greater C10-C18 alpha-olefin content and having a weight average molecular weight of from about 1,000,000 g/mol to about 10,000,000 g/mol.

Abstract: A method of preparing a branched polymer comprises the free radical polymerisation of a multivinyl monomer in the presence of a chain transfer agent, using a source of radicals, wherein the extent of propagation is controlled relative to the extent of chain transfer to prevent gelation of the polymer. The average length of each vinyl polymer chain within the product is short.

Abstract: The present invention relates to a high-density ethylene-based polymer and a pipe using the same, the high-density ethylene-based polymer including: an ethylene homopolymer; or a copolymer of ethylene and at least one comonomer selected from the group consisting of an ?-olefin, a cyclic olefin and linear, branched and cyclic dienes. The pipe using the high-density ethylene-based polymer of the present invention has more superior strain hardening than a conventional polyethylene resin pipe, and thus has excellent long-term pressure resistance characteristics and processability.

Abstract: The present invention pertains to a vinylidene fluoride polymer, to a process for manufacturing said vinylidene fluoride polymer and to an article comprising said vinylidene fluoride polymer.

Abstract: The present invention provides a polymer-polyol and its composition for producing photochromic coating products. The polymer-polyol is prepared by copolymerization of acrylate concluding hydroxy or not. The composition includes: (i) matrix resin; (ii) polymer-polyol mentioned above; and (iii) photochromic compound. And the solid content of the hydroxyl group in the composition is about 1.0%-6.0%. The composition has good compatibility with other functional coatings, such as unique organosilane hard coating and/or antireflective coating. It is appropriate for preparing the photochromic coating products which can be used in the ophthalmology field.

Abstract: Polyolefin elastomers are widely employed commodity polymers. There remains a desire to expand the structural diversity of polyolefin elastomers to facilitate their use in additional applications. Polyolefin elastomers may be graft copolymers that comprise: a first polymer chain comprising at least a first olefinic monomer comprising isobutylene and a second olefinic monomer bearing a benzylic carbon atom or an allylic carbon atom, and a second polymer chain bonded to the benzylic carbon atom or the allylic carbon atom of the first polymer chain. The second polymer chain comprises at least one monomer that is not present in the first polymer chain. The second polymer chain may be bonded to the first polymer chain by generating a carbanion upon the benzylic carbon atom or the allylic carbon atom and growing the second polymer chain by anionic polymerization.

Abstract: A (meth)acrylic copolymer (A) having a mass average molecular weight of 50,000 to 1,000,000, in which the (meth)acrylic copolymer (A) is obtained by polymerizing a monomer mixture including a macromonomer (a) that has a number average molecular weight of 500 or more and less than 6000 and a vinyl monomer (b), and preferably includes 7 to 40% by mass of a repeat unit derived from the macromonomer (a), has sufficient coating workability, adhesive holding power and adhesive property as an adhesive composition.

Abstract: Process for the preparation of styrenic polymers having an improved color stability by anionic polymerization wherein the obtained terminated polymer solution is fed to a dispersing device to which water is added, fed to a buffer vessel and then is impregnated in a static mixer by addition of further water, carbon dioxide and one or more stabilizers.

Abstract: A styrenic block copolymer having one or more polymer blocks A and one or more polymer blocks B is disclosed, where “A” is a poly(vinylaromatic) block having a molecular weight of greater than 5 kg/mol. The “B” block has a molecular weight of more than 15 kg/mol, and comprises polymerized 1,3-diene units and vinylaromatic units, wherein the polymerized vinylaromatic units represent 5-40 wt. % of the overall weight of the block “B”. The polymerized 1,3-diene units comprise more than 80 wt. % of polymerized isoprene units in which 45-80 mol % are 1,4-isoprene addition units. The blocks “A” and “B” represent from >5 to <40 wt. %, and >33 to <95 wt. %, respectively, relative to the overall weight of the block copolymer. The polymers have physical properties that make them valuable, e.g., as vibration damping materials.

Abstract: The present invention relates to polymerizable compositions which contain components that can be crosslinked both via isocyanurate bonds and by a radical reaction mechanism. The invention further relates to methods by way of which polymers can be produced from said compositions.

Abstract: The present invention relates to polyester-based hard thermoplastic polyurethane systems which are impact-resistant at low temperatures, and to the production and use thereof.

Abstract: Disclosed herein are polyurethanes useful for polishing layers, where the polyurethane is a polyurethane having a Schiff base. Also disclosed herein are polishing layers containing the polyurethanes, polishing methods that use the polishing layers, and a modification method including a step of converting the Schiff base into at least one functional group selected from an aldehyde group, a carboxylic acid group, a hydroxyl group, and an amino group.

Abstract: The present invention relates to compositions comprising a) 20-80% by weight, based on the total mass of constituents of the composition, of at least one sulfonic acid functionalized with at least one hydroxy and/or amino group and/or at least one sulfonic acid derivative functionalized with at least one hydroxy and/or amino group and b) 80-20% by weight, based on the total mass of constituents of the composition, of at least one compound having at least two OH groups, a method for the preparation thereof and use thereof.

Abstract: A xylylenediisocyanate composition including xylylenediisocyanate and a compound represented by Chemical Formula (1) below, wherein 0.

Abstract: Compositions including a thermosetting polymer network and a mechanophore covalently bonded to the thermosetting polymer network are provided. Substrates including the compositions are provided. In addition, methods of making the compositions and methods of monitoring stress on a substrate comprising the compositions are provided.

Abstract: A curable composition of the present invention includes a cationic polymerizable compound; a thermal polymerization initiator; and a storage stabilizer, in which the cationic polymerizable compound includes at least two selected from the group consisting of a glycidyl ether compound, an alicyclic epoxy compound, and an oxetane compound, a content of the thermal polymerization initiator is from 0.3 to 3 parts by mass with respect to 100 parts by mass of the cationic polymerizable compound, and chain curing is enabled by thermal energy generated by a polymerization reaction of the cationic polymerizable compound.

Abstract: A heat-curing epoxy resin compositions which can in particular be used as bodyshell adhesives for motor vehicle construction. The heat-curing epoxy resin compositions contain a curing agent which can be activated through elevated temperature and has a first component K1 containing at least one epoxy resin and a second component K2 containing at least one tertiary amine and also a primary amine. These compositions, after short-term heating of 30 to 120 seconds at a temperature of 90° C. to 130° C., exhibit sufficient strength and adhesion to withstand transport-induced mechanical strains.

Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.

Abstract: In an embodiment, a composition is provided that includes an indenofluorene moiety; an alkyl radical, an aryl radical, or a heteroaryl radical chemically bound to the indenofluorene moiety; and an electron donor moiety bound to the indenofluorene moiety. In another embodiment, a device is provided that includes compositions described herein. In another embodiment, a method of forming a donor-acceptor small molecule or a donor-acceptor copolymer is provided that includes forming an indenofluorene moiety; forming an electron donor moiety; and reacting the indenofluorene moiety with the electron donor moiety in a cross-coupling reaction.