Abstract: An abdominal electrocardiogram processing system for determining a fetal heart rate of a fetus in a pregnant woman obtains a combined electrocardiogram measurement of a maternal heart rate and a fetal heart rate. The system then transforms the combined electrocardiogram measurement into a wavelet domain to create a combined electrocardiogram measurement wavelet transform. The system can then remove the maternal heart rate from the combined electrocardiogram measurement wavelet transform. The system then identifies a fetal heart rate from the compensated combined electrocardiogram measurement wavelet transform.

Abstract: Methods for joining a flexible circuit to a strut for, for example, use on an electrode array, including connecting the flexible circuit to the array using a rivet and expanding an end of the rivet using heat staking or alternative processes to maintain the connection.

Abstract: A method for identifying cardiac bradycardia behavior may include acquiring pulse volume wave data from a sensor associated with a patient, and calculating metrics associated with peaks detected therein. The metrics may include changes in peak amplitudes of pulse volume peaks and in the times of occurrence of pulse volume peaks. Alternative metrics may include changes in frequency domain parameters derived from the time domain pulse volume wave data. Peak amplitude values may be compared to an amplitude baseline, and differences in successive peak occurrence times may be compared to a time baseline. Cardiac bradycardia behavior may be identified by a combination of a decrease in the pulse volume peak amplitude and an increase in successive peak occurrence times. A system to implement the method may include a computing device in data communication with a photo-plethysmograph. Alternative sensors may include a blood pressure cuff and an ECG device.

Abstract: Method and device for calculating an indicator indicative of stress and device for on-line detecting stress using individual heart beat ECG features of data acquired from a subject, comprising: obtaining a data sample of each heart beat individually from the acquired data; calculating the fiducial features from each said data sample; classifying each data sample as indicative of stressed or not-stressed, using a pretrained classifier which was previously trained using the same fiducial heart beat features from previously acquired reference data samples from individual heart beats, determining an indication of stress as detected when at least one data sample is classified as stressed. Stress can be determined as detected when one data sample is classified as stressed over a time duration of: only one heart beat and the RR distance between said one heart beat and the previous heart beat.

Abstract: A physiological signal sensing system and a physiological signal sensing method are provided. The physiological signal sensing system includes a signal processing device and a physiological signal sensing device having a plurality of sensing electrodes. The sensing electrodes are used to contact the skin of an organism to sense a plurality of physiological signals. The signal processing device is coupled to the physiological signal sensing device to receive the physiological signals, compares these physiological signals with the reference physiological signal pattern to obtain a comparison result, selects a selected electrode pair from the sensing electrodes based on the comparison result, and uses the selected electrode pair to perform physiological signal measurement on the organism during a normal operation period.

Abstract: A monitoring system including a master device adapted for wireless communication with at least one slave device having a sensor. The sensor of the at least one slave device is adapted for acquiring a physiological signal. The master device is adapted for providing a synchronization signal to the at least one slave device and instructing the at least one slave device to acquire the physiological signal based on timing instructions. The at least one slave device is adapted for acquiring the physiological signal by means of the sensor according to the received timing instructions and transmitting the acquired physiological signal wirelessly to the master device. The master device includes a processor for processing the synchronized, physiological signals acquired by sensors synchronized via wireless communication.

Abstract: An exemplary embodiment providing one or more improvements includes apparatus and methods for sensing electrical activity in tissue of a person in a manner which is substantially limits or eliminates interference from noise in a surrounding environment.

Abstract: A read-out circuitry for acquiring a multi-channel biopotential signal, comprises: a plurality of read-out signal channels, each receiving an input signal from a unique signal electrode; a reference channel receiving a reference signal from a reference electrode; wherein each read-out signal channel and the reference channel comprises a channel amplifier connected to receive the input signal in a first input node and with an output node connected to a second input node via a channel feedback loop; wherein each signal channel amplifier comprises a capacitor between the second input nodes of the signal channel amplifier and the reference channel amplifier, and wherein each signal channel feedback loop and the reference channel feedback loop comprise a filter.

Abstract: A device for monitoring a health parameter in a person is disclosed. The device includes a semiconductor substrate, at least one transmit antenna configured to transmit millimeter range radio waves over a 3D space below the skin surface of a person, multiple receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, wherein the semiconductor substrate includes circuits for processing signals received on the multiple receive antennas, wherein processing signals includes mixing signals of two different frequencies, and wherein the semiconductor substrate includes at least one output configured to output a signal that corresponds to a health parameter of a person in response to received radio waves.

Abstract: A system for monitoring a health parameter in a person is disclosed. The system includes at least one transmit antenna configured to transmit millimeter range radio waves over a 3D space below the skin surface of a person, multiple receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, and means for isolating a signal from a particular location in the 3D space in response to receiving the radio waves on the multiple receive antennas and outputting a signal that corresponds to a health parameter of the person in response to the isolated signal.

Abstract: A method for monitoring a health parameter in a person is disclosed. The method involves transmitting radio waves below the skin surface of a person and across a range of stepped frequencies, receiving radio waves on a two-dimensional array of receive antennas, the received radio waves including a reflected portion of the transmitted radio waves across the range of stepped frequencies, generating data that corresponds to the received radio waves, wherein the data includes amplitude and phase data, and determining a value that is indicative of a health parameter in the person in response to the amplitude and phase data.

Abstract: A method for operating a health parameter monitoring system is disclosed. The method involves transmitting radio waves below the skin surface of a person, receiving radio waves on a two-dimensional array of receive antennas of an antenna array, the received radio waves including a reflected portion of the transmitted radio waves, determining an alignment of the antenna array relative to a vein in the person in response to the received radio waves, and outputting a signal that is indicative of the determined alignment of the antenna array relative to the vein.

Abstract: A device for monitoring a health parameter of a person is disclosed. The device includes a device body, a radio frequency (RF) front-end connected to the device body and including a semiconductor substrate and an antenna array including at least one transmit antenna configured to transmit radio waves below the skin surface of a person and a two-dimensional array of receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, wherein the semiconductor substrate includes circuits configured to generate signals in response to the received radio waves, and an alignment feature integrated into the device body and configured to align the antenna array with an object.

Abstract: A removable smartphone case is disclosed. The removable smartphone case includes a case body configured to receive a smartphone, a radio frequency (RF) front-end connected to the case body and including a semiconductor substrate and an antenna array including at least one transmit antenna configured to transmit radio waves below the skin surface of a person and a two-dimensional array of receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, wherein the semiconductor substrate includes circuits configured to generate signals in response to the received radio waves, a communications interface connected to the case body and configured to transmit digital data that corresponds to the signals generated by the semiconductor substrate from the removable smartphone case, and an alignment feature integrated into the case body and configured to align the antenna array with an object.

Abstract: An alignment element to be worn by a person is disclosed. The alignment element includes an attachment element configured to attach to the skin of a person and an alignment feature integrated into the attachment element and configured to align an antenna array of a health monitoring device with an object.

Abstract: A method for monitoring a health parameter in a person involves engaging an alignment feature of a health monitoring device with an alignment feature of an alignment element that is worn on the skin, transmitting radio waves from at least one transmit antenna of the health monitoring device below the skin surface of the person while the alignment feature of the health monitoring device is engaged with the alignment feature of the alignment element that is worn by the person, receiving radio waves on a two-dimensional array of receive antennas of the health monitoring device while the alignment feature of the health monitoring device is engaged with the alignment feature of the alignment element that is worn by the person, generating digital data that corresponds to the received radio waves, and determining a value that is indicative of a health parameter of the person in response to the digital data.

Abstract: A strap to be worn by a person is disclosed. The strap includes a strap piece configured to be worn by a person, a radio frequency (RF) front-end integrated into the strap piece and including a semiconductor substrate, at least one transmit antenna configured to transmit radio waves below the skin surface of a person, and a two-dimensional array of receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, wherein the semiconductor substrate includes circuits configured to generate signals in response to the received radio waves, and a wireless communications interface integrated into the strap piece and configured to wirelessly transmit digital data that corresponds to the signals generated by the semiconductor substrate from the strap piece.

Abstract: A magnetic resonance imaging (MRI) visualization method includes identifying a location of a thermally induced lesion in an MRI image by deriving a spatial pattern of MRI pixel values, which represents the lesion as it is expected to appear in the MRI image, as a function of thermal energy applied in creating the lesion. The MRI image is matched with the spatial pattern of pixel values. A local maximum value is found in the matched MRI image, and a location of the local maximum value is presented in the matched MRI image as the location of the lesion.

Abstract: The present invention provides methods and apparatuses for detecting, measuring, or locating cells or substances present in even very low concentrations in vivo in subjects, using targeted magnetic nanoparticles and special magnetic systems. The magnetic systems can comprise magnetizing subsystems and sensors subsystems, including as examples SQUID sensors and atomic magnetometers. The magnetic systems can detect, measure, or location particles preferentially internalized by cells due to the action of antibodies, proteins, macromolecules, or nutrients required for cellular metabolism. Example magnetic systems are capable of detecting sub-nanogram amounts of these nanoparticles.

Abstract: Described herein are systems and methods for calibrating dry electrode bioelectrical impedance measurements. These method and apparatuses may be used for sensing bioelectrical impedance for ambulatory and or long-term measurements. Calibration of bioelectrical impedance sensing may be performed by using measurements taken during a shorted configuration of the apparatus, in which the same current is applied to both the source and sink stimulation electrodes, to modify measurements taken in a forward and/or reverse configuration in which current is applied to either the source and/or sink.

Abstract: An electrophysiological laboratory system comprises a subsystem configured to perform diagnostic and/or therapeutic functions, a medical device, and an interface module disposed therebetween. The medical device comprises a shaft having proximal and distal portions, high- and low-impedance electrical pathways disposed within the shaft, and an electrode disposed at the distal portion of the shaft and electrically coupled to one or both of the high- and low-impedance electrical pathways. The electrode is configured to perform diagnostic and/or therapy delivery functions. The interface module comprises a high-impedance channel configured to couple the high-impedance pathway of the medical device to the subsystem, and to attenuate magnetic resonance RF and gradient field pulses generated by the MRI system. The interface module further comprises a low-impedance channel configured to couple the low-impedance pathway of the medical device to the subsystem.

Abstract: In one embodiment, a body part visualization system includes a medical instrument configured to be inserted into a body part of a living subject, a display, and processing circuitry configured to compute location coordinates of the medical instrument in the body part, and render to the display a first three-dimensional (3D) representation of the body part, the first 3D representation showing an external surface of the body part with a moving window, which moves over the external surface in the first 3D representation responsively to the computed location coordinates of the medical instrument so as to provide, via the window, an internal view of the first 3D representation of the body part, the internal view including a second 3D representation of at least a part of the medical instrument at the computed location coordinates.

Abstract: An imaging system includes an ultrasound probe, and an interventional medical device having a tracking device. The ultrasound probe includes an ultrasound transducer to generate an ultrasound field-of-view, a tracking field generator to generate an electromagnetic locator field, and a wireless receiver. The interventional medical device has a distal end portion to which the tracking device is mechanically coupled. The tracking device includes a plurality of tracking coils, a wireless transmitter, and a power supply circuit. The plurality of tracking coils interact with the electromagnetic locator field to determine a location within the electromagnetic locator field and to generate tracking data. The wireless transmitter is configured to transmit the tracking data from the tracking device of the interventional medical device to the wireless receiver of the ultrasound probe. The power supply circuit is configured to supply electrical power to the wireless transmitter of the tracking device.

Abstract: The present invention relates to the field of medical monitoring, and, in particular, to non-contact detecting and monitoring of patient breathing. Systems, methods, and computer readable media are described for calculating a change in depth of a region of interest (ROI) on a patient and assigning one or more visual indicators to at least a portion of a graphic based on the calculated changes in depth and/or based on a tidal volume signal generated for the patient. In some embodiments, the systems, methods, and/or computer readable media can display the visual indicators overlaid onto at least the portion in real-time and/or can display the tidal volume signal in real-time. The systems, methods, and/or computer readable media can trigger an alert and/or an alarm when a breathing abnormality is detected.

Abstract: A system comprises a mouth piece to receive exhaled air; a breath chamber to receive exhaled air; a valve to direct exhaled air along a desired flow path, direct purge gas along a desired flow path, control the rate of flow of purge gas, control the rate of flow of exhaled air, block the flow of purge gas, and/or block the flow of exhaled air; a source of purge gas; a CO2 cartridge to remove CO2; a water cartridge to remove water; a breath cartridge to capture VOCs from exhaled air; a temperature control system to control the temperature of CO2 cartridge, a water cartridge, and/or a breath cartridge; a cryostat to contain and limit heat flow to a cryogenic liquid; a flow meter designed to measure the flow of exhaled air and/or purge gas; and a pressure transducer to measure a pressure, a flow rate, and/or a flow volume.

Abstract: A method, a computer-readable storage device, and an apparatus for predicting a fall are disclosed. In one example, a method performed by a processor deployed in a communications network includes collecting gait information associated with a user from a first wearable device worn by the user, collecting electroencephalography information associated with the user from a second wearable device worn by the user, calculating a likelihood that the user will fall within a threshold period of time from a current time, wherein the calculating is based on a combination of the gait information and the electroencephalography information; and sending an instruction to an endpoint device associated with the user when the likelihood exceeds a predefined threshold, wherein the instruction instructs the endpoint device to generate an alert alerting the user that a fall is likely.

Abstract: A shoe-type device and a control method of the shoe-type device are disclosed. A control method of a shoe-type device including an actuator and at least one sensor includes estimating a posture of a user wearing the shoe-type device based on sensor data output from the sensor, and controlling the actuator based on the estimated posture of the user.

Abstract: A standing desk system, method, and device. A user is detected proximate a standing desk. A position and orientation of the user are determined. Time periods associated with the position and the orientation are detected.

Abstract: An implantable optical sensor (1) comprising a substrate (2) and at least one optical microstructure (3) for evanescent field sensing integrated with the substrate (2), the at least one optical microstructure (3) being positioned to form an optical interaction area (4) on a part of a surface (5) of the substrate (2), the optical assembly (1) further comprising a thin protective layer (6) covering at least the optical interaction area (4), the thin protective layer (6) being in a predetermined material with corrosion-protection characteristics and having a predetermined thickness, so as not to affect the evanescent field sensing.

Abstract: A sensing system comprises a photonics integrated circuit partially encapsulated by an encapsulation material and the photonics integrated circuit comprising a first integrated sensor accessible to a target analyte and being positioned in a part of the photonics integrated circuit not being encapsulated by an encapsulation material, and a second integrated sensor accessible to a reference substance and being positioned in a part of the photonics integrated circuit that is encapsulated by an encapsulation material. The sensing system is further adapted to, when in use, comprise the reference substance but less or no target analyte between the second integrated sensor and the encapsulation material as compared to the amount of target analyte being present at the first integrated sensor.

Abstract: The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

Abstract: An apparatus for estimating blood glucose using a photoplethysmography (PPG) signal is provided. The apparatus for estimating blood glucose includes: a pulse wave sensor configured to obtain a pulse wave signal from an object; and a processor configured to obtain at least two points from a waveform of the pulse wave signal, to extract a feature based on time values of the obtained at least two points, and to estimate blood glucose based on the extracted feature.

Abstract: A method for monitoring a blood glucose level in a person involves transmitting millimeter range radio waves over a three-dimensional (3D) space below the skin surface of a person. receiving radio waves on multiple receive antennas, the received radio waves including a reflected portion of the transmitted radio waves, isolating a signal from a particular location in the 3D space in response to receiving the radio waves on the multiple receive antennas, and outputting a signal that corresponds to a blood glucose level in the person in response to the isolated signal.

Abstract: A system for monitoring a health parameter in a person is disclosed. The system includes a frequency synthesizer configured to generate radio waves across a range of stepped frequencies, at least one transmit antenna configured to transmit the radio waves below the skin surface of a person, a two-dimensional array of receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, processing circuits configured to generate data that includes amplitude and phase data in response to the received radio waves, and means for determining a value that corresponds to a health parameter of the person in response to the amplitude and phase data.

Abstract: Disclosed herein is a method for determining a dosing prescription for a medicament in a patient undergoing CRRT. The method generally includes administering to the bloodstream of the patient a fluorescent agent; administering to the patient at least one dose of the medicament; performing CRRT on the patient after administering the fluorescent agent to the patient; exposing the fluorescent agent to visible or infrared light; monitoring transcutaneously a change in the spectral energy from the fluorescent agent over a period of time; correlating a change in intensity of the spectral energy from the fluorescent agent to a clearance rate of the fluorescent agent from the bloodstream in the patient; calculating a clearance rate of the medicament in the patient; determining an amount of the medicament in the bloodstream of the patient as a function of time; and adjusting a dosing prescription of the medicament to the patient.

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract: A detection method for causing a computer to execute processing includes acquiring image information obtained by imaging a subject in a moving body, acquiring illuminance information that indicates an illuminance in the moving body, generating first feature information regarding a time-series change in a pupil diameter of the subject on the basis of the acquired image information, generating second feature information regarding a time-series change in the illuminance in the moving body on the basis of the acquired illuminance information, generating reaction information regarding a reflection speed of a pupil of the subject with respect to light emitted to the subject on the basis of the generated first and second feature information, and detecting a fatigue state of the subject on the basis of the generated reaction information.

Abstract: There is provided a method for determining perceptual experiences. The method comprises obtaining a plurality of signals acquired by a measurement device comprising a plurality of sensors positioned to measure brain activity of users being measured by the measurement device; providing the plurality of signals, without pre-processing, to a processing system comprising at least one deep learning module, the at least one deep learning module being configured to process the signals to generate at least one capability, wherein combinations of one or more of the at least one capability form the perceptual experiences; and providing an output corresponding to a combination of one or more of the at least one capability to an application utilizing the corresponding perceptual experience.

Abstract: The invention relates to a method for quantifying the balance of an individual to obtain a value representative of the balance of said individual, said method being implemented by a device comprising at least one data processing module connected to a storage means and said method comprising: a) a step of recording, on the storage means, at least one statokinesigram of the individual obtained from a platform comprising pressure and/or force sensors, b) a step of extracting, by the data processing module and from the one or more statokinesigram(s) of the individual recorded on the storage means, values of at least one position trajectory parameter of the pressure center and values of at least one stability trajectory parameter of the pressure center, c) a step of determining, by the data processing module, the value of several quantifiers, from the values of the trajectory parameters extracted in step b), d) a step of comparing, by the data processing module, said values of several quantifiers with the value

Abstract: A system and associated method for computerized rotational head impulse test (crHIT) to assess the semicircular canals of the human vestibular system clinically in patients with balance disorders. The system utilizes a rotary chair combined with a head mounted VOG system with head tracking sensors. The crHIT protocol uses the same physiologic principles as the known video head impulse test (vHIT). The crHIT utilizes whole-body rotation via the chair to yield a persistent controlled, repeatable, comfortable, reliable stimulus can be delivered while recording eye movements with video-oculogaphy.

Abstract: Disclosed is a vertigo diagnosis and treatment system including a frame, a revolution device, a rotation device and a seat, the frame comprising a primary frame and a secondary frame arranged oppositely. The revolution device includes a power mechanism and a slewing frame. The slewing frame is arranged between the primary frame and the secondary frame. The primary frame and the secondary frame provide slewing support for the slewing frame. The rotation device includes a power mechanism and a seat rotating frame. The vertigo diagnosis and treatment system further includes a seat biasing mechanism. Under the combined action of the revolution device and the rotation device, the vertigo diagnosis and treatment system according to the present invention can realize three-dimensional free rotation and hovering in any position, thus achieving vertigo diagnosis and treatment.

Abstract: In an embodiment, a seizure monitor provides intelligent epilepsy seizure detection, monitoring, and alerting for epilepsy patients or people with seizures. In an embodiment, the seizure monitor may be a wearable, non-intrusive, passive monitoring device that does not require any insertion or ingestion into the human body. In an embodiment, the seizure monitor may include several output options for outputting the accelerometer/gyro or other motion sensor data and video data, so that the data may be immediately validated and/or remotely viewed. The device alerts are communicated to the outside care givers via wireless or wired medium. The device may also support recording of accelerometer or other motion sensor data and video data, which can be reviewed later for further analysis and/or diagnosis. The device and invention is also used and applicable for other body motion disorders or detection and diagnostics.

Abstract: A wearable electronic device may alert a wearer as to a presence of either a range of allergens or to specific pollen to which the individual is allergic. As such, the device may warn the user of bioparticles likely to affect them allergenically. The device may include an airflow path. A deterministic lateral displacement (DLD) array may be positioned within the airflow path to capture bioparticles of a particular size. An imaging device may capture images of captured bioparticles. The system may include a database of bioparticles in a range of sizes. The system may be configured to compare the captured bioparticles to the information in the database. A wearer may be alerted if bioparticles potentially allergenically problematic to the person have been found in the captured bioparticles.

Abstract: A method, system, and computer readable storage medium for determining a glossiness value of a skin of a user are provided. In an embodiment, a polarized light having a property value is emitted from a portable light source towards the portion of the skin of the user. The portable light source is coupled to a handheld device. The polarized light is cast on the portion of the skin of the user from the portable light source. Reflected light reflected from the portion of the skin of the user is measured using a sensor coupled to the handheld device. The reflected light has a property value. A ratio between the property values of the emitted polarized light and the measured reflected light is determined using a processor of the handheld device. The glossiness value of the portion of the skin of the user is determined based on the determined ratio.

Abstract: Exemplary embodiments relate to a skin-adherable electronic device including a semiconductor circuit unit including a circuit element including an electrode and an interconnect, and a semiconductor device including an insulating layer and an active layer; and a flexible patch that can adhere to skin and including a plurality of through-holes, wherein the insulating layer includes a plurality of through-holes corresponding to the plurality of through-holes of the flexible patch, and a method of manufacturing the same. When the active layer is made of a piezoelectric material, the electronic device may be used as a skin sensor that can acquire skin deformation and/or elasticity information.

Abstract: A device for treating bone in a living body includes (a) comprises an implant configured for attachment to a bone; (b) a first sensor measuring a strain on a first portion of the implant, the first portion of the implant being configured to be mechanically coupled to a weakened portion of a bone when the implant is coupled to the bone in a target position in combination; and (c) a second sensor measuring strain in a non-weakened portion of the bone.

Abstract: A system, instrumentality, and method for performing an oral care evaluation of a user via electrical impedance tomography (EIT). For example, a system may include an oral care device having a first member housing a first electrode. The first electrode may be configured to transmit a first signal through a gingiva of a user to cause an altered first signal. The oral care device may have a second member housing a second electrode. The second electrode may be configured to receive the altered first signal. The system may be configured to generate an electrical impedance tomography (EIT) profile of the gingiva of the user, for example, based on data indicative of the first signal and the altered first signal. An oral health characteristic of the user may be determined based on the EIT profile of the gingiva of the user.

Abstract: Described herein are methods of classifying periodontal patients and individual teeth. For example, disclosed is a method of diagnosing periodontal disease and/or risk of tooth loss in a subject that involves classifying teeth into one of 7 classes of periodontal disease. The method can include the step of performing a dental examination on a patient and determining a periodontal profile class (PPC). The method can further include the step of determining for each tooth a Tooth Profile Class (TPC). The PPC and TPC can be used together to generate a composite risk score for an individual, which is referred to herein as the Index of Periodontal Risk (IPR). In some embodiments, each stage of the disclosed PPC system is characterized by unique single nucleotide polymorphisms (SNPs) associated with unique pathways, identifying unique druggable targets for each stage.

Abstract: A system screens, diagnoses, or monitors sleep disordered breathing of a patient. The system may include a nasal cannula, a conduit connected to the nasal cannula at a first end, an adaptor configured to receive a second end of the conduit and/or a portable computing device. The adaptor may be configured to position the second end of the conduit in proximity with a microphone of the portable computing device. Optionally, a processor may generate an indicator to guide placement of the adaptor for use. Such positioning may, in use, permit the microphone to generate a patient breathing sound signal via the adaptor for processor(s) of the device. The processor(s) may then process the breathing sound signal. The process may include detecting SDB events from an extracted and/or de-rectified loudness signal. The process may include computing a metric of severity of a respiratory condition of the patient using detected SDB events.

Abstract: Systems and method for age-compensated monitoring of a patient experiencing administration of at least one drug having anesthetic properties are provided. In one embodiment, a system includes a plurality of sensors configured to acquire physiological data from the patient and at least one processor configured to receive the physiological data from the plurality of sensors, and determine, from the physiological data, signal markers indicative of an apparent or likely patient age. The at least one processor is also configured to at least one of scale and regulate the physiological data using at least the apparent patient age to create age-compensated data, and generate a report including the age-compensated data.