Abstract: Pill sorting devices are described herein that include a cavity formed from a bottom, a front, a first side wall, and a second side wall, a channel formed at the intersection of the first side wall and the second side wall, and a delivery channel within the front and first side wall or the within the front and the second side wall, wherein the delivery channel is offset from the channel. The pill sorting, counting, and dispensing device can be useful for people with arthritis or poor sight, or could be used commercially in pharmacies or industrially. Methods of making and using the pill sorting, counting, and dispensing devices are also described.

Abstract: The invention relates to the application of photon energy to energize dental materials to enhance their physical handling characteristics, efficacy, ability to be delivered, reactivity, polymerization, and/or post-cure mechanical properties, among other attributes.

Abstract: An oil-in-water emulsified cosmetic comprising an aqueous medium, an anionic surfactant, an oil agent, an amphiphilic polymer selected from the group consisting of hydrophobic group-modified hydrophilic urethane polymers, (meth)acrylic polymers having a side chain including hydrophilic and hydrophobic groups, and hydrophobic group-modified hydrophilic polysaccharides, and a charge neutralizer, wherein the cosmetic has a viscosity of 10,000 mPa·s or higher at 25° C.

Abstract: An oil-in-water type emulsion cosmetic is capable of stably maintaining large-sized oily particles having a diameter exceeding 50 ?m in a well-dispersed state or achieving a well-dispersed state thereof merely by lightly shaking, without necessarily adding a water-soluble thickener such as carboxyvinyl polymer to the aqueous phase of the emulsion. The oil-in-water type emulsion cosmetic, wherein oily particles containing a solid fat component and a liquid oil component are dispersed in an aqueous phase, is characterized in that: the average particle diameter of the oily particles is 50 ?m to 10 mm; and the difference between the specific gravity of the oily phase constituting the oily particles and the specific gravity of the aqueous phase [(specific gravity of oily phase)?(specific gravity of aqueous phase)] is within the range of ?0.010 to +0.100.

Abstract: The present invention deals with organic cosmetic active molecules encapsulation into temperature-responsive and pH-responsive oligo(ethylene glycol)-based biocompatible microgels that are incorporated into cosmetic compositions for controlled delivery on skin or hair.

Abstract: This invention relates to dentifrice compositions comprising a high level of sodium bicarbonate and a stannous ion source, as well as to methods of using these compositions. Optionally, the dentifrice compositions further comprise zinc oxide.

Abstract: Disclosed herein are high water oral care compositions comprising a stannous ion source, which compositions have improved stability. Methods of making and using the compositions are also provided.

Abstract: The present invention relates to a stable powder composition comprising hair direct dyes which is used for dyeing hair after mixing with one or more aqueous compositions. The composition comprises one or more direct dyes selected from HC Red 18, HC Blue 18, and HC Yellow 16, one or more alkanolamine as alkalizing agent, an organic and/or an inorganic pulverulent excipient.

Abstract: Described herein are oral care compositions comprising an orally acceptable carrier; an abrasive system comprising a calcium-based abrasive; and a core shell silica particle comprising; a metal silicate; and a silica particle comprising a core having a surface; wherein the metal silicate is chemically bound to a surface of the silica core; and wherein the metal silicate comprises a silicate of a divalent metal ion. Methods of making and using these compositions are also described.

Abstract: Provided herein are methods of treating one or more symptoms of a gastric disorder in the oral cavity of a subject in need thereof, wherein the method comprises applying to the subject's teeth an oral care composition comprising a basic amino acid in free or salt form, wherein the basic amino acid is arginine (e.g., free form arginine); zinc oxide and zinc citrate; and an orally acceptable carrier.

Abstract: The present invention relates to hair care compositions comprising malodor reduction compositions and methods of using such hair care compositions. Such hair care compositions comprising the malodor control technologies disclosed herein provide malodor control without leaving an undesirable scent and when perfume is used to scent such compositions, such scent is not unduly altered by the malodor control technology.

Abstract: A hair conditioning composition comprising a) a conditioning base comprising, by total weight of the hair conditioning composition, i) from 0.4 to 8 wt % of fatty alcohol having from 8 to 22 carbons, ii) from 0.1 to 2 wt % of cationic surfactant, b) a hydrophobically modified anionic polymer; and c) water, wherein the composition confers a Draw Mass of from 1 to 250 g to hair treated with the conditioning composition; a method of saving water during a rinse step in a hair conditioning process comprising the steps of applying to hair the hair treatment composition and rinsing the hair with water; and a use of a hydrophobically modified anionic polymer in the hair treatment composition, to save water during a hair conditioning process.

Abstract: Disclosed is an anhydrous makeup removing composition and method for removing making using such a composition. The composition includes at least two esters having a molecular weight less than 350 g/mol and a polarity index of less than or equal to 24.2 mN/m, where the composition contains less than 5 w/w % of any esters having molecular weights greater than 350 g/mol or having a polarity index greater than 24.2 mN/m, or any non-ester hydrocarbons. The esters may have a surface tension as measured at 20° C. of less than 40 dynes/cm, and the composition may also include additional components, such as a filler particle, a dye, a polymeric thickener, a preservative, and/or a fragrance. In some embodiments, the composition may consist solely of between two and four such esters, and in various embodiments, may be a solution, a gel, or an emulsion.

Abstract: A subject matter of the present invention is the cosmetic use of at least one compound of formula (I): in which: denotes a divalent radical chosen from a carbon-carbon single bond *—CH2—CH2—* or double bond *—CH—CH—*, of Z or E configuration or their mixtures, b=0 or 1, c=0 or 1, d=0, 1 or 2, and R and R? independently denote a hydrogen atom, a linear C1-C6 alkyl radical or a branched C3-C6 alkyl radical, to treat and/or prevent signs of aging and/or of photoaging of keratinous substances, preferably of the skin, and/or to depigment, lighten and/or whiten keratinous substances, preferably the skin. The present invention also relates to novel compounds and to a corresponding cosmetic method.

Abstract: An antimicrobial composition suitable for use on human skin and containing a UV-detectable compound that will allow for detection of the application of the composition, using a UV-light source. A kit comprising such an antimicrobial composition and a UV-light source.

Abstract: Cosmetic agents having a reduced amount of active ingredient, without adversely affecting the deodorizing effect, which also have excellent storage stability, contain in a cosmetically acceptable carrier ethylenediamine disuccinic acid and/or salts thereof and at least one benzalkonium chloride of the formula (I) in which R stands for —H or -ethyl and n stands for an integer from the group of 7, 9, 11, 13, 15 or 17, with the proviso that the total amount of compound(s) of formula (I) is from about 0.05 to about 5% by weight, based on the agent.

Abstract: The present invention relates to novel aqueous N-acyl glycinate compositions wherein the said compositions are free-flowing, pumpable, phase-stable on long-term storage, and processable at sub-zero temperatures; more specifically below ?5° C. The present invention also relates to the use of these aqueous N-acyl glycinate compositions in preparing isotropic aqueous skin and hair cleansing formulations such as body wash, shower gels, shampoos, and other.

Abstract: Provided herein are methods of treating one or more symptoms of a gastric disorder in the oral cavity of a subject in need thereof, wherein the method comprises applying to the subject's teeth an oral care composition comprising a basic amino acid in free or salt form, wherein the basic amino acid is arginine (e.g., free form arginine); zinc oxide and zinc citrate; and an orally acceptable carrier.

Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride with a slight molar excess of amino acid hydrohalide, as well as oral care compositions comprising said complexes made according to said method.

Abstract: An agent for the oxidative dyeing of keratinic fibers, in particular human hair, contains in a cosmetic carrier (A) at least one oxidation dye precursor with 4,5-diaminopyrazole as the basic structural element, (B) iminodisuccinic acid or a physiologically compatible salt, and (C) at least one oxidizing agent different from atmospheric oxygen.

Abstract: A bath salt composition and method of making thereof includes providing dried Cannabis leaves containing THC and defining THC grind and dried Cannabis leaves having deactivated THC and defining THCA grind. The THC grind and the THCA grind are ground together to define a mixed grind. The mixed grind is blended with 8 parts refined avocado oil and cooked define a cooked mixture. The THC grind and THCA grind are strained from the cooked mixture to define a strained mixture which is poured onto Epson salt to define a composition. The composition is dried and placed into an airtight container until used in bathwater.

Abstract: Provided are methods of treating hair, the method comprising: contacting the hair with a mixture comprising: i. an ionic liquid comprising an imidazolium-based compound or ammonium-based compound, and ii. an anionic surfactant. In certain methods, the mixture further comprises a cationic direct dye.

Abstract: A stick-shaped base material capable of having a breaking strength required for a stick-shaped base material even when the amount of a lipid peptide compound contained therein is reduced, including: a surfactant; water; a lipid peptide compound including at least one of compound of the following Formula (1) and similar compound thereof or pharmaceutically usable salts of the compounds: wherein R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group optionally having a C1 or C2 branched chain; and R3 is a —(CH2)n—X group, wherein n is a number of 1 to 4, and X is an amino group, guanidine group, or a —CONH2 group, or a 5-membered or 6-membered ring optionally having one to three nitrogen atoms or a fused heterocyclic ring composed of the rings; a 1,2-alkanediol or a 1,3-alkanediol; at least one fatty acid; and an alginic acid derivative.

Abstract: The present disclosure relates to a peptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, 3, or 4, a pharmaceutical composition for preventing or treating skin disease including the peptide, a cosmetic composition for skin condition improvement including the peptide, a food composition for skin condition improvement including the peptide, a method of preventing or treating skin disease using the peptide, and a use of the peptide in preventing or treating skin disease or improving skin condition.

Abstract: A skin administration system capable of ensuring the stability of peptides or proteins and enhancing the delivery rate of peptides or proteins through the skin and, more particularly, microneedles including peptides or proteins are provided. Microneedles including a protein or peptide are also provided, in particular microneedles including a microparticle including a peptide or a protein, in particular wherein the peptide or the protein is stably entrapped inside the microparticle, more particularly without aggregation. The material forming the microneedle can be soluble in the skin and the protein or the peptide can be stably delivered into the skin as the microneedle is dissolved or disintegrated when the microneedle is applied to the skin.

Abstract: A hair botox contains, as a weight ratio, 5% to 30% of keratin in a weight of 100 g of water. This ratio is preferred as being between 15% and 30% keratin for excessively worn hair, and between 5% and 15% keratin for less worn hair. In the invention, in addition to 5%-30% keratin in 100 g of water, if desired, vitamins, minerals, herbal extracts, other proteins, other than keratin, and materials used in the cosmetic field may be used in a rate of 0.001% to 20% each.

Abstract: The present invention relates to the novel trypsin ZT isoforms. In particular, the invention relates to the use of trypsin ZT isoforms in medical devices, pharmaceuticals and cosmetics.

Abstract: An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.5 wt-% to 4.8 wt-% of a water-soluble cationic N-containing polymer, a pharmaceutically acceptable buffer, 1.0 wt-% to 2.5 wt-% of sodium fluoride; and at least 60 wt-% water, wherein the weight percentages are based on the total weight of the aqueous composition.

Abstract: Leave-on ethanol-free water-based perfumed compositions which are stable during storage, in particular remain clear during storage, and which are non-irritating to the skin. An ethanol-free perfumed composition including water, a perfume and an ester, wherein the ester includes an ethoxylated glyceride derived from carboxylic acids having 6 to 22 carbon atoms moiety.

Abstract: A herb-based hair dye formulation includes one or more ingredients selected from coloring agent, enhancing agent, toning agent and auxiliary agent of herb origin. Also disclosed is a method for producing a herb-based product, and particularly a method for manufacturing the herb-based hair dye formulation.

Abstract: The present invention refers to dermocosmetic formulations for use against skin blemishes, especially melasma. The present invention minimizes or avoids the formation of melasma by acting in several stages of melanogenesis. A preferred embodiment of the invention refers to dermocosmetic formulations that act in several stages of melanogenesis, preferably, in the gene expression of tyrosinase-related proteins (TYRP-1 and TYRP-2) and Endothelin-1 (ET-1). Another embodiment of the invention refers to the cosmetic composition containing a combination of active ingredients that act on the gene expression of tyrosinase-related proteins (TYRP-1 and TYRP-2) and Endothelin-1 (ET-1). In another preferred embodiment of the invention, the use of said cosmetic composition to combat melasma is described.

Abstract: Compositions, methods, and kits for cleansing, moisturizing, soothing, cooling, such as those, for example, that may be used to cleanse, moisturize, soothe, and cool the body or portions thereof.

Abstract: The present invention provides new Cannabis lines, extracts and methods for skin rejuvenation and healing and protection against harmful environmental factors such as UV rays and other damaging agents. The method includes generation of unique lines, whole plant extract preparation, exposing human 3D skin tissues to UV and treating human 3D skin tissues with extracts in amount sufficient to modulate gene expression in the skin tissues before and after UV exposure. The modulation of gene expression then results in a reduction of the disease state-associated changes or aspects thereof in the cannabis-treated skin tissues.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a JAK inhibitor.

Abstract: The present invention relates generally to methods of use and compositions useful for increasing procollagen-1 expression in the skin, increasing lysyl oxidase expression in the skin, inhibiting melanogenesis in the skin, and/or increasing expression of elastin in the skin. The composition includes a combination of one or more of Himanthalia elongata extract, Undaria pinnatifida extract, Saussurea involucrata extract, Morus alba fruit extract, Citrus aurantium dulcis (orange) callus culture extract, Argania spinosa kernel extract, and/or Opuntia tuna fruit extract.

Abstract: Described herein are methods and devices for the long term treatment of ophthalmic disorders. Also disclosed are encapsulated cell therapy (ECT) devices that secrete a biologically active molecule and methods for using the same for the treatment of various kinds of ophthalmic disorders, including retinitis pigmentosa, geographic atrophy (dry age-related macular degeneration), glaucoma and/or macular telangiectasia.

Abstract: Apparatus and method for delivering cannabinoids such as CBD to users are disclosed. A source of a cannabinoid of interest is combined with a blend of herbs in an aromatherapy wrap garment. The user heats the garment to thereby volatilize the cannabinoid and the essential oils in the herbs. The volatilized oils flow through the fabric garment and are both inhaled by the user and absorbed transdermally. Heat retention ingredients such as flax seed or other grains, including but not limited to rice, barley and other materials such as clay or plastic beads may be included in the garment.

Abstract: An active mesh nebulizer is used to generate a distribution of liquid particles or droplets having a diameter ranging from about 0.5 to about 5 micrometers (?m). Delivery and ingestion, by inhalation, of ethyl alcohol solution particles leads to rapid uptake of the alcohol solution by brain tissue, and avoids damage to the liver, gastrointestinal tract, and/or peripheral nervous system consistent with drinking ethyl alcohol. A brain effect of ethyl alcohol absorbed through alveoli in the lung occurs within less than 60 seconds, and body effects of alcohol consumption are reduced or eliminated. Delivery of ethyl alcohol to a user by absorption through alveoli provides a user with a brain effect while allowing tissue damage from drinking alcohol to heal. A lock out barcoded capsule containing ethyl alcohol, tethered to a smartphone application, prevents unauthorized use by non-designated users, or abuse by a designated user.

Abstract: The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nanodispersion that can be readily aerosolized for inhalation.

Abstract: The present invention relates to a hydrogel formulation for delivering probiotics including a hydrogel, probiotics and zwitterionic buffer as an active ingredient, a composition for delivering probiotics comprising the same and a method of preparing the same, which adjust and maintain the internal pH of the hydrogel even in the gastric juice environment, thereby increasing the survival rate of the probiotics in the gastric juice and improving the delivery rate to the large intestine, by further adding zwitterionic buffer capable of maintaining pH to the hydrogel encapsulated with probiotics.

Abstract: Ready to use liquid formulations of diclofenac potassium are disclosed which are particularly well suited for packaging in stick-packs.

Abstract: Dental treatments and methods, including treating gum disease, using peroxide gel and a viscous antibacterial agent including tetracycline to chemically debride and curettage a treatment area. Treatments and methods include non-surgically scaling and root plaining the treatment area with dental tools such as periodontal scalers and/or curettes during the active period of the chemical debridement. The working surfaces of dental tools can be sharpened for optimal root and tooth surfacing during treatment. Treatment can include instructions for co-therapy by or on behalf of treatment subjects between visits and for maintenance care.

Abstract: The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.

Abstract: An object of the present invention is to provide a tumor therapeutic agent and a kit which have superior antitumor effects as compared with gemcitabine, a taxane antitumor agent, and a combination therapy thereof which have been put on the market. According to the present invention, there is provided a tumor therapeutic agent obtained by combining a taxane antitumor agent with a liposome composition in which gemcitabine or a salt thereof is contained in a liposome.

Abstract: Provided herein are cationic liquid crystalline nanoparticles (CLCNs). Further provided herein are methods of delivering RNAi using the CLCNs for the treatment of diseases.

Abstract: The present invention is directed to peptisomes, including nanopeptisomes, which have a perfluorocarbon liquid core containing a perfluorocarbon liquid and a cargo, such as a therapeutically active agent, dispersed in the perfluorocarbon, liquid, and a plurality of amphiphilic peptide molecules surrounding the perfluorocarbon liquid core, wherein the amphiphilic peptide is represented by Formula (I) HB-CL-HP wherein HB is a fluorinated hydrophobic block, such as a fluorinated hydrophobic amino acid sequence. CL is a cross-linking motif and HP is a hydrophilic amino acid sequence. The present invention is also directed to methods of use of the amphiphilic peptides and peptisomes, such as nanopeptisomes, to deliver a cargo, such as a therapeutically active agent, to a cell, Q wherein the cell may be in vitro, ex vi, or in vivo.

Abstract: The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.

Abstract: The present invention provides compositions and formulations of biologically active compounds complexed with a solid lipid particle which is able to traverse the blood-retinal barrier and treat retinal and neurological diseases.

Abstract: Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.

Abstract: Embodiments of the invention relate to a process for enhancing the bioavailability of poorly soluble active ingredients, and to formulations of powders made by such process. Embodiments of the invention comprise a spinodal decomposition method by which low, sparingly or poorly-soluble materials are converted to amorphous materials with, improved or enhanced solubility suitable for therapeutic use. The powder formulations are useful for the treatment of diseases and conditions, especially respiratory diseases and conditions.