Abstract: A DNA or genome sequencing structure is disclosed. The structure includes an electrode pair, each electrode having a tip-shaped end, the electrodes separated by a nanogap defined by facing tip-shaped ends; at least one conductive island deposited at or near each tip-shaped end; and a biomolecule having two ends, each end attached to the conductive islands in the electrode pair such that one biomolecule bridges over the nanogap in the electrode pair, wherein nucleotide interactions with the biomolecule provides electronic monitoring of DNA or genome sequencing without the use of a fluorescing element.

Abstract: Sensor clip assemblies, sensor clips, analyte testing systems, and methods for making and using the same are disclosed. A sensor clip assembly is disclosed for storing and dispensing analyte testing sensors. The sensor clip assembly includes numerous test sensors arranged in a stack. Each test sensor is configured to assist in testing an analyte in a fluid sample. The sensor clip assembly also includes a skeletal frame with a top, a bottom, and numerous sides. The top, bottom and sides are interconnected to define an internal chamber within which is stored the stack of test sensors. At least one of the sides includes one or more elongated rails with structural gaps on opposing sides thereof. For some configurations, multiple sides of the skeletal frame comprise at least one or multiple elongated rails, each of which has structural gaps on opposing sides thereof and may be columnar in nature.

Abstract: Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided.

Abstract: A method of and system for detecting a gas or vapor includes providing a sensor comprising an electrode pair in electrical contact with a layer of porous material, the porous material layer having water adsorbed on its surface; contacting the sensor with a gas or vapor sample to be analysed; applying a voltage across the electrode pair of the sensor; and measuring a response, the response correlating to the presence of a target gas or vapor.

Abstract: In the method of preparing a sample for analysis, a reaction is performed that produces different modified product depending on the sialic acid linkage type when a sialic acid is bound to a sugar chain of an analyte. In this reaction, an analyte containing a sugar chain, an amine containing two or more carbon atoms, and a dehydration-condensation agent are used. The sialic acid linkage type can be identified by analyzing the resulting sample with mass spectrometry etc. This method is applicable not only to free sugar chains but also to glycopeptides and glycoproteins.

Abstract: A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The microfluidic device includes a surface defining one or more microfluidic channels, a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels, a second three dimensional scaffold, at least a portion of which is contacting and in fluid communication with the first three dimensional scaffold, and that is spatially separated from the one or more microfluidic channels, and a third three dimensional scaffold, at least a portion of which is contacting and in fluid communication with the one or more microfluidic channels and the second three dimensional scaffold. The device can be used to assay anti-cancer agents, or as a system for modeling the growth, behavior, or metastasis and tumor formation of cancer cells.

Abstract: Disclosed is an assay device which comprises a liquid sample addition zone, a reagent zone, a detection zone, and a wicking zone, all defining a fluid flow path. The device further comprises a reagent addition zone along and in fluid communication with the fluid flow path downstream of the sample addition zone and upstream of the detection zone. An interrupting wash is added at this reagent addition zone in accordance with the method of the subject invention to control sample volume. The interrupting wash fluid is added at a predetermined fill volume on the chip device and also serves to wash the detection channel and fill the remaining chip volume.

Abstract: Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bPBP). Upon binding of ligand to the biosensor, there is a change in the signal transduced by the reporter group.

Abstract: Assays, arrays, and methods for distinguishing a bacterial infection from a viral infection are disclosed. The antibiotic crisis is in part driven by over prescription of antibiotics. There is a tendency, particular in pediatrics, to give an antibiotic even for viral infections. Thus, embodiments herein are directed to the problem of distinguishing a bacterial infection from a viral infection to reduce unnecessary antibiotic usage.

Abstract: This invention relates to methods for diagnosing cancer, e.g., cancer of epithelial origin, by detecting the presence of tumor cells in a sample, based (at least in some embodiments) on the quantification of levels of four biomarkers, MUC1, EGFR, EpCAM, and HER2. In some embodiments, the methods are performed using diagnostic magnetic resonance (DMR), e.g., with a portable relaxometer or MR imager.

Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: Cancers of different cellular or tissue origins express different ENOX2 cancer isoforms or combinations of isoforms and shed these proteins into the circulation. Herein are disclosed methods both for cancer detection and diagnosis of particular origin, based on the patterns and molecular weights of the isoforms which allow the identification of the cell type and or tissue of origin of the neoplasm. Relative ENOX2 amounts are proportional to tumor burden and provide a reliable measure of response to therapy and disease progression. Also provided is the amino acid sequence to which the scFv antibodies bind as the molecular basis for the specificity of the test.

Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.

Abstract: Sensing compositions, sensing element, sensing systems and sensing devices for the detection and/or quantitation of one or more analytes. Compositions comprising carbon nanotubes in which the carbon nanotubes retain their ability to luminesce and in which that luminescence is rendered selectively sensitive to the presence of an analyte. Compositions comprising individually dispersed carbon nanotubes, which are electronically isolated from other carbon nanotubes, yet which are associated with chemical selective species, such as polymers, particularly biological polymers, for example proteins, which can interact selectively with, or more specifically selectivity bind to, an analyte of interest. Chemically selective species bind, preferably non-covalently, to the carbon nanotube and function to provide for analyte selectivity. Chemically selective species include polymers to which one or more chemically selective groups are covalently attached.

Abstract: Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.

Abstract: The present invention is directed to KIM-1 polypeptide as a plasma acute and chronic kidney injury and renal cell carcinoma biomarker, and methods and kits comprising the use of agents specific to KIM-1 for facilitating and enhancing the diagnosis of kidney injury or carcinoma. The present invention is based on the discovery that measuring KIM-1 levels in the blood is more accurate and reliable than measuring KIM-1 levels in the urine for the diagnosis of subjects with proximal kidney tubule injury or kidney cancer. The invention is directed to methods for diagnosis of acute kidney injury, chronic kidney disease (CKD), and renal cell cancer by determining and monitoring the levels of KIM-1 polypeptide in a blood sample, such as plasma or serum sample.

Abstract: The present invention relates a method for the diagnosis, prediction or risk stratification for mortality and/or disease outcome of a subject that has or is suspected to have sepsis, comprising determining the presence and/or level of antitrypsin (ATT) or fragments thereof in a sample taken from said subject and/or determining the presence and/or level of transthyretin (TTR) or fragments thereof, wherein the presence and/or level of ATT and/or TTR or fragments thereof is correlated with an increased risk of mortality and, wherein said increased risk of mortality and/or poor disease outcome is given if the level of ATT is below a certain cut-off value and/or the level of fragments thereof is above a certain cut-off value and/or said increased risk of mortality and/or poor disease outcome is given if the level of TTR is below a certain cut-off value and/or the level of fragments thereof is below a certain cut-off value.

Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

Abstract: In alternative embodiments are provided methods, devices and systems that use clinical data to determine whether bilirubin binding is normal in a newborn infant with hyperbilirubinemia in order to detect in vivo neurologically toxic levels of bilirubin and to determine whether treatment is needed to prevent a bilirubin-induced neurological injury (e.g. encephalopathy). In alternative embodiments, also provided are devices and systems comprising automated micro-fluid handling technologies such as zone fluidics systems to obtain a bilirubin binding panel. In alternative embodiments, also provided are methods for using the bilirubin binding panel to determine if treatments are needed to ameliorate, reverse, or prevent a bilirubin-induced neurological injury (e.g. encephalopathy) in an individual in need thereof such as a newborn with hyperbilirubinemia (jaundice), and for commencing the treatment, if needed.

Abstract: Disclosed is an antibody which binds to olanzapine, which can be used to detect olanzapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of olanzapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.

Abstract: A particle counting device includes a scanner probe having a first opening for receiving particles from a sample surface and second openings. Pumps produce a first airstream flowing from the first opening and a second airstream flowing to the second openings. A flow device splits the first airstream into third and fourth airstreams. A first particle detector detects particles in the third airstream. The first particle detector is capable of detecting particles within a first range of particle sizes. A second particle detector detects particles in the fourth airstream. The second particle detector is capable of detecting particles within a second range of particle sizes different from the first range of particle sizes. Control circuitry controls the flow device and the pumps to provide a first flow rate of the third airstream and a second flow rate of the fourth airstream that is larger than the first flow rate.

Abstract: A picking instrument for picking biological samples, such as microbial samples, includes a picking pin having a distal tip and three degrees-of-freedom and configured to move in x, y, and z directions. The picking instrument also includes a loading platform comprising a first area and a second area, the first area configured to accommodate and secure a microfabricated chip including a plurality of microwells. The picking pin is programmatically controlled to pick a sample contained in one or more selected microwells of the microfabricated chip and then transfer the sample to a predetermined location at the destination sample holder. Methods of operating the picking instrument, including calibrating the coordinates of the selected microwell(s) relative to a location of the picking pin, are also provided.

Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.

Abstract: A muzzle-mounted chronograph for measuring velocities of projectiles launched from firearms. The chronograph includes a sensor module and a controller. The sensor module includes a first and second coils and a device for applying a stable magnetic field to the first and second coils. The controller determines a velocity of a projectile passing by the first and second coils based on detected variations in magnetic fields at the first and second coils.

Abstract: A flexure for a MEMS device includes an elongated beam and a protrusion element extending outwardly from a sidewall of the elongated beam. A MEMS inertial sensor includes a movable element spaced apart from a surface of a substrate, an anchor attached to the substrate, and a spring system. The spring system includes first and second beams, a center flexure between the first and second beams, a first end flexure interconnected between an end of the first beam and the anchor, and a second end flexure interconnected between an end of the second beam and the movable element. Each of the end flexures includes the elongated beam having first and second ends, and the sidewall defining a longitudinal dimension of the elongated beam, and the protrusion element extending from the sidewall of the elongated beam, the protrusion element being displaced away from the first and second ends of the beam.

Abstract: An integrated circuit measures a differential change between first and second mutual capacitances having receiver electrodes joined to form a common electrode of an MEMS circuit. The integrated circuit performs charge transfer measurements to transfer charge to a reference capacitor and a variable capacitor is used to change the amount of charge stored in the reference capacitor. First and second charge transfer measurements are performed, each having a number of charge transfer cycles used to transfer charge from the common electrode to the reference capacitor. In the first measurement, a transmit electrode of the first capacitance is driven high first, and in the second measurement, a transmit electrode of the second capacitance is driven high first. The circuit compensates for parasitic capacitances in the MEMS circuit with a sample-and-hold circuit selectively connected to the common electrode to maintain its voltage during a charge phase of a charge transfer cycle.

Abstract: Systems and methods are disclosed for identifying portable devices carried by the same person. An example method includes receiving media exposure data from one of a plurality of portable computing devices. Receiving segmented accelerometer data from the plurality of portable computing devices. Forming accelerometer classification data for the plurality of portable computing devices based on features extracted from the segmented accelerometer data. Comparing the accelerometer classification data for the first portable computing device to accelerometer classification data for the plurality of portable computing devices, to determine if the accelerometer classification data for the first portable computing device is sufficiently similar to a second portable computing devices.

Abstract: This disclosure relates to a system and method for calibrating sensors upon installation in a vehicle. The system includes a sensor set configured to generate output signals conveying vectors of acceleration of the vehicle. The system determines a three-dimensional orientation of the sensor set in relation to the vehicle. The system converts output signals from the sensor set into vectors of acceleration of the vehicle.

Abstract: Provided is a scanning probe microscope with which measurement data and a distribution image of differential data of the measurement data can be displayed selectively or together, an edge enhancement image can be obtained, and user convenience is improved. A scanning probe microscope (200) includes: a distribution image calculator (40a) configured to calculate a one-dimensional or two-dimensional first distribution image (201) of measurement data, and a one-dimensional or two-dimensional second distribution image (202) of differential data of adjacent data elements of the measurement data; and a display controller (40b) configured to instruct the distribution image calculator to calculate at least one of the first distribution image or the second distribution image, and to display the calculated distribution image on a predetermined display.

Abstract: An example metrology device can include a first stage including a microelectromechanical (MEMS) device having a probe, and a second stage configured to hold a sample. The metrology device can also include a kinematic coupler for constraining the first stage in a fixed position relative to the second stage. The probe of the MEMS device can be aligned with a portion of the sample when the first stage is constrained in the fixed position relative to the second stage.

Abstract: A liquid cell for in situ atomic force microscopy (AFM) measurement of a sample during filtration is provided. The liquid cell includes a cantilever probe; a cantilever holder to position the probe near a surface of a sample (e.g., a filtration membrane); a liquid cell housing provided to hold the sample and comprising an opening at the top; an upper part; a lower part; an internal cavity to contain a fluid; a fluid inlet passage located in the upper part; a first fluid outlet passage located in the upper part; and a second fluid outlet passage located in the lower part. A method of in situ atomic force microscopy (AFM) measurement of a sample during filtration in a liquid by using the liquid cell described herein is also provided.

Abstract: An electrical probe includes a probe assembly and a second electrical connection member. The probe assembly includes a needle cylinder, a first electrical connection member, a probe head and a sub-probe. The first electrical connection member and the probe head locate to two opposite sides of the needle cylinder. The first electrical connection member and the probe head electrically connect the needle cylinder. The sub-probe penetrates the probe head, and plugs the needle cylinder to electrically connect a cable but being electrically isolated from the needle cylinder. The sub-probe is located on a side away from the first electrical connection member. When the probe head depresses the object, the needle cylinder drives the first cylinder to a contact position to allow the first electrical connection member to electrically contact the second electrical connection member, and thus the probe head connects the second electrical connection member via the needle cylinder.

Abstract: A method for analyzing at least one signal by using a measurement and analyzing device is described. At least one measurement on said signal to be analyzed is conducted in order to obtain at least one measurement value. A diagram comprising said at least one measurement value over the time is provided. A curve of said at least one measurement value over the time is derived from said diagram. At least one trigger function is applied to said derived curve such that a trigger event is generated in case said at least one trigger function is triggered by said derived curve. Further, a measurement and analyzing device is described.

Abstract: A device for integrated current measurement inside a high-voltage contact-making means of a hybrid module includes a printed circuit board with at least one current sensor chip that is arranged on the printed circuit board. The device further includes a high-voltage contact-making plug connection, which is mounted on the printed circuit board. The high-voltage contact-making plug connection has at least one Hall ring and one busbar that is passed through the Hall ring, wherein the Hall ring has an open cross section and the sensor chip is at least partially accommodated in the open cross section.

Abstract: Embodiments of the present disclosure provide mechanisms for measuring currents flowing in one or more conductor wires. The mechanisms are based on using magnetic sensor pairs arranged within a housing with an opening for the wires, where each magnetic sensor pair can generate a pair of signals indicative of magnetic fields in two different directions. The outputs of the sensor pairs can be used to derive a measure of current(s) flowing through the one or more wires. The use of magnetic sensor pairs that can measure magnetic field in two different directions may enable simultaneous current measurement in multiple wires placed within the opening, improve accuracy of current measurements while relaxing requirements for precise control of the placement of the wire(s), reduce the impact of stray magnetic interference, and enable both AC and DC measurements.

Abstract: A current sensor includes plural bus bars which are each formed rectangular in a cross section, a pair of shield plates that include a magnetic material and are arranged so as to collectively sandwich the plural bus bars therebetween, and plural magnetic detection elements that are each arranged between the bus bars and one of the shield plates. A distance d between a detection position of a magnetic field intensity at an arbitrary one of the magnetic detection elements and a center position in the width direction between one of the bus bars corresponding to the arbitrary magnetic detection element and an other of the bus bars adjacent thereto in the width direction satisfies the following expression: d/w+0.023(w/h)?0.36 where a width of the shield plates is w and an interval along a height direction of the shield plates is h.

Abstract: A power inductor includes: a body including a magnetic material; an internal coil disposed in the body and including a plurality of coil patterns; and a sensing coil disposed on the body and facing the internal coil.

Abstract: A current measurement device including current sensors positioned around current conductors in order to form a passage for the current conductors along an axis oriented in a first direction and a differential current sensor positioned around the set of current conductors in order to form a common passage for the current conductors along an axis oriented in a second direction. The current sensors and the differential current sensor are located in spaces that are separated by an interface plane. A method for manufacturing such a current measurement device, to a protection module and a differential circuit breaker including such a device.

Abstract: The subject matter of this specification can be embodied in, among other things, a method for characterizing a fluid injector that includes receiving a collection of waveform data, identifying a pull locus, determining a detection threshold level value, identifying a first subset of the collection of data representative of a selected first electrical waveform of the collection of electrical waveforms, identifying an opening value, identifying a representative closing value, identifying an anchor value, identifying a second subset of the collection of data based on the collection of data, the pull locus, the first subset, and the opening value, identifying a maximum electrical value, identifying an opening locus based the collection of data, the anchor value, and the maximum electrical value, identifying a hold value, and providing characteristics associated with the fluid injector comprising the pull locus, the opening locus, the hold value, the anchor value, and the representative closing value.

Abstract: As means for solving the above-described problem, there is provided a data processing device (1) including a measurement data acquisition unit (10) that acquires measurement data indicating a temporal change in at least one of current consumption and power consumption of an electrical apparatus, a reference component extraction unit (20) that extracts a reference component of the current consumption and a reference component of the power consumption from the measurement data, and a feature value acquisition unit (30) that acquires a feature value of each reference component.

Abstract: In order to solve the above-described problem, there is provided a data processing device (1) including a measurement data acquisition unit (10) that acquires measurement data indicating a temporal change in at least one of current consumption and power consumption of an electrical apparatus, a fluctuation component extraction unit (20) that extracts a fluctuation component related to fluctuation in the current consumption and a fluctuation component related to fluctuation in the power consumption from the measurement data, and a feature value acquisition unit (30) that acquires a feature value of the fluctuation component.

Abstract: A method for measuring an impedance of each of a plurality of piezoelectric actuators of a print head, each piezoelectric actuator connected to electronic selection circuitry of the print head that drives the piezoelectric actuators during a print operation. The method includes generating a waveform to drive a drive rail of the print head, the drive rail connected to the electronic selection circuitry of the print head and measuring an impedance of each of the plurality of piezoelectrical actuators of the print head through the electronic selection circuitry.

Abstract: Systems and methods for recording and communicating engine data are provided. One example embodiment is directed to a method for performing diagnostics on an antenna in communication with a wireless communication unit located in a nacelle of an aerial vehicle engine. The method includes receiving, by one or more computing devices, a voltage from a diagnostic circuit for the antenna. The method includes determining, by the one or more computing devices, a change in a magnitude of the received voltage. The method includes determining, by the one or more computing devices, a condition of the antenna based on the change in the magnitude of the voltage.

Abstract: Various embodiments provide a multi-dimensional electric potential sensor array to remotely quantitatively measure static, quasi-static, and dynamic electric potential and electric field in free space, and emanating and propagating from objects. Various embodiments enable the evaluation of the integrity of electronic circuits and electronic components by quantitatively and dynamically imaging electric potential generated during electronic circuit activation, operation, and deactivation. In various embodiments, the electrical potential of active electronics and objects of interest in containers may be quantitatively measured by the electric potential and electric field methods and by using specified materials in a combined structural and electronic component design to construct a multi-dimensional sensor array.

Abstract: Provided is an electromagnetic compatibility testing system and method for data on-screen display, the electromagnetic compatibility testing system for data on-screen display includes a testing unit, a data acquiring unit, a camera monitoring unit, and an on-screen display controlling unit, wherein the data acquiring unit is configured to acquire the first test data generated by the testing unit, extract target data from the first test data, generate a second test data, and send the obtained second test data to the on-screen display controlling unit; the camera monitoring unit is configured to perform a video monitoring on a test area, and send the obtained video data to the on-screen display controlling unit; and the on-screen display controlling unit is configured to display the received second test data and the video data on the same screen.

Abstract: A method for fabricating a semiconductor structure includes when a chip under test releases an ESD current, detecting position information of photons emitted from the chip under test due to releasing of the ESD current; acquiring an image of an ESD path based on the detected position information of the photons; and determining whether the ESD path corresponding to the chip under test is normal based on the image of the ESD path and a layout image of the chip under test.

Abstract: A device for inserting n number of the electronic components into n number of housing recess in a carrier tape at once includes an imaging device that images, at an imaging position provided at an upstream side of the insertion position, a portion of the carrier tape that contains the n number of housing recesses; and a processor that determines, on the basis of an image captured by the imaging device, a two-dimensional position of each of the n number of housing recesses contained in the image relative to a reference point in the image, and that causes a two-dimensional position of the insertion position for the n number of the housing recesses that have been imaged by the imaging device to be corrected in accordance with the captured image so as to mitigate positional deviations of the n number of the housing recesses in the tape.

Abstract: A semiconductor device structure is provided. The semiconductor device structure includes a substrate, an electrical connection structure extending upwardly from an upper surface of the substrate by a first height, and a contact pad electrically disposed on the upper surface of the substrate. The contact pad has a solder-wettable surface with an area configured to support a solder ball having a second height at least twice the first height. The semiconductor device structure further includes a fuse element with a first end electrically coupled to the electrical connection structure and a second end electrically coupled to the contact pad.

Abstract: An inspection jig includes a rigid substrate, a flexible substrate connected to the rigid substrate, a support supporting a part of the flexible substrate in a state that the part of the flexible substrate is protruded with respect to the rigid substrate in a first direction, a biasing unit configured to bias the support in the first direction with respect to the rigid substrate, and a contactor provided on a protruding portion of the flexible substrate, the protruding portion being protruded with respect to the rigid substrate. The contactor includes a contact housing, and a probe supported on the contact housing. One end of the probe is in contact with a contact portion on the protruding portion.