Patents Issued in July 16, 2020
  • Publication number: 20200223772
    Abstract: The disclosure relates to a method for fluorinating an alkane substrate comprising contacting said alkane substrate with a fluoroalkane in the presence of a fluorination catalyst selected from chrome oxide, fluorinated chrome oxide, aluminum oxide and fluorinated aluminum oxide at elevated temperatures.
    Type: Application
    Filed: September 9, 2016
    Publication date: July 16, 2020
    Applicant: THE CHEMOURS COMPANY FC, LLC
    Inventor: Xuehui SUN
  • Publication number: 20200223773
    Abstract: A method for preparing tetrafluoropropene utilising three reactors is described. Each reactor comprises a catalytic bed containing a catalyst or a preliminary catalyst. The method comprises the implementation, separately in each of the reactors, of catalytic reactions or reactions regenerating the catalyst, the quantity of catalyst or preliminary catalyst in the catalytic bed of one of the reactors representing between 90% and 110% of the quantity of catalyst or preliminary catalyst contained in the catalytic bed of one of the other two reactors. A facility configured to implement the method is also described.
    Type: Application
    Filed: March 25, 2020
    Publication date: July 16, 2020
    Inventors: Dominique DEUR-BERT, Dominique GARRAIT, Anne PIGAMO, Laurent WENDLINGER
  • Publication number: 20200223774
    Abstract: A plant for the manufacture of tetrafluoropropene comprises three reactors for reaction in the gas phase comprising a catalyst bed. The first and second reactor are each configured in order to be fed in turn by a device for feeding with a reaction stream comprising a compound B and hydrofluoric acid; and a device for feeding with a regeneration stream configured in order to feed the reactor with a regeneration stream comprising an oxidizing agent. The third reactor is configured in order to be fed in turn by a device for feeding with a reaction stream comprising a compound A and hydrofluoric acid; said compound A being different from said compound B; and a device for feeding with a regeneration stream configured in order to feed the reactor with a regeneration stream comprising an oxidizing agent.
    Type: Application
    Filed: April 1, 2020
    Publication date: July 16, 2020
    Inventors: Dominique DEUR-BERT, Dominique GARRAIT, Anne PIGAMO, Laurent WENDLINGER
  • Publication number: 20200223775
    Abstract: A carbon dioxide electrolytic device of an embodiment includes: an anode part including an anode which oxidizes water or hydroxide ions to produce oxygen; a cathode part including a cathode which reduces carbon dioxide to produce a carbon compound, a cathode solution flow path which supplies a cathode solution to the cathode, and a gas flow path which supplies carbon dioxide to the cathode; a separator which separates the anode part and the cathode part; and a differential pressure control unit which controls a differential pressure between a pressure of the cathode solution and a pressure of the carbon dioxide so as to adjust a production amount of the carbon dioxide produced by a reduction reaction in the cathode part.
    Type: Application
    Filed: March 26, 2020
    Publication date: July 16, 2020
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Yuki KUDO, Akihiko ONO, Masakazu YAMAGIWA, Eishi TSUTSUMI, Yoshitsune SUGANO, Ryota KITAGAWA, Jun TAMURA, Satoshi MIKOSHIBA
  • Publication number: 20200223776
    Abstract: A process for the synthesis of methanol from an input stream of synthesis gas, comprising the following steps: subjecting a portion of said input stream as feed stream to an adiabatic reactive step, providing an effluent containing methanol and unreacted synthesis gas; quenching of said effluent with a further portion of said input stream, providing a quenched stream; subjecting said quenched stream to an isothermal reactive step, providing a methanol-containing product stream.
    Type: Application
    Filed: June 30, 2017
    Publication date: July 16, 2020
    Applicant: Casale SA
    Inventors: Pietro Moreo, Maddalena Lepri
  • Publication number: 20200223777
    Abstract: A process for preparing a compound of formula (I) HR1R2C—CF2—(C?O)—Y starting with a compound of formula (II) R1R2C?CX—(C?O)—Y or of formula (III) HR1R2C—CX1X2—(C?O)—Y placed in contact with hydrofluoric acid; R1 and R2 being independently selected from H, F, Cl, Br, I, C1-C20-alkyl, C6-C20-aryl and C2-C20-alkenyl, C3-C20-cycloalkenyl and C3-C20-cycloalkyl; X1 and X2 being independently selected from F, Cl, Br and I on condition that X1 and X2 are not simultaneously F; Y being selected from the group of H, C1-C20-alkyl, C1-C20-haloalkyl, C6-C20-aryl, —OH, —OR, —NH2, —NHR, —NR2, —SR, C3-C20-cycloalkyl, C3-C20-cycloalkenyl and C2-C20-alkenyl; R being independently selected from the group of C1-C20-alkyl, C6-C20-aryl and C2-C20-alkenyl, C3-C20-cycloalkenyl and C3-C20-cycloalkyl.
    Type: Application
    Filed: May 22, 2018
    Publication date: July 16, 2020
    Applicant: Arkema France
    Inventor: Laurent WENDLINGER
  • Publication number: 20200223778
    Abstract: The present invention concerns a process for the reduction of content of carboxylic acids and derivatives thereof in oleum, disulfuric acid or concentrated sulfuric acid. The invention further concerns a process for the manufacture of carboxylic acid anhydrides comprising the process for the reduction of content of carboxylic acids and derivatives thereof from oleum, disulfuric acid or concentrated sulfuric acid.
    Type: Application
    Filed: April 25, 2018
    Publication date: July 16, 2020
    Inventors: Jean-Marie BLAUDE, Benoit GOSSELIN, Alain LAMBERT, Mathias MAREK, Harald KRUEGER, Jan Schostag, Miriam Heyd
  • Publication number: 20200223779
    Abstract: The present teachings disclose contacting an amine salt catalyst with a dicarbonyl compound having an alkylene group between the carbonyl group; adding formaldehyde, paraformaldehyde, or formalin in an amount of about 2:1 to about 3:1 moles of formaldehyde to moles of the dicarbonyl compound to form a mixture; and refluxing the mixture. The process forms a carbonyl-substituted alkene. The process may be performed in the absence of a solvent. The process may form methylene malonates, methylene dimalonates, methylene keto malonamides, methylene diketones, methylene keto esters, and the like.
    Type: Application
    Filed: September 12, 2018
    Publication date: July 16, 2020
    Inventors: Jeffrey M. Sullivan, Ami Doshi, Kshitij Kishen Parab
  • Publication number: 20200223780
    Abstract: A method for producing esters of an alpha, beta-unsaturated carboxylic acid are disclosed, the method includes reacting a three or four carbon beta-hydroxyalkanoate composition or mixtures thereof with a mono-alcohol under heating conditions to form a reaction product and distilling the reaction product to recover a composition containing at least fifty percent by weight of the ester of the alpha, beta-unsaturated carboxylic acid.
    Type: Application
    Filed: April 1, 2020
    Publication date: July 16, 2020
    Applicant: CARGILL, INCORPORATED
    Inventors: Timothy Walter ABRAHAM, Ravi R. Gokarn
  • Publication number: 20200223781
    Abstract: A compound expressed in the following formula (1) (where R1 and R2 independently denote a hydrogen atom or a methyl group, Y1 and Y2 independently denote an alkylene group having a carbon number of 1 to 9, and n1 and n2 independently denote an integer of 0 to 3).
    Type: Application
    Filed: March 26, 2020
    Publication date: July 16, 2020
    Applicant: NIKON CORPORATION
    Inventors: Yoshihiro SOMEYA, Masayuki SHIJO
  • Publication number: 20200223782
    Abstract: A (meth)acrylate compound excellent in compatibility with other photosensitive resins and capable of providing a polymer with high transparency, a polymer, a resist material, and a method for producing the (meth)acrylate compound. The (meth)acrylate compound is represented by formula (1).
    Type: Application
    Filed: December 18, 2019
    Publication date: July 16, 2020
    Applicant: JNC CORPORATION
    Inventors: DAISUKE INOKI, TEIZI SATOU, HIDEKI HAYASHI
  • Publication number: 20200223783
    Abstract: The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
    Type: Application
    Filed: March 26, 2020
    Publication date: July 16, 2020
    Applicant: XW LABORATORIES INC.
    Inventors: JIA-NING XIANG, XUESONG XU, XUAN ZHANG
  • Publication number: 20200223784
    Abstract: The present invention generally relates to processes for the catalytic hydrogenation of halonitroaromatics. In particular, the present invention includes processes for the catalytic hydrogenation of halonitroaromatics such as 2,5-dicloronitrobenzene to 2,5-dichloroaniline over a platinum-containing catalyst. The present invention also relates to processes for producing 3,6-dichloro-2-methoxybenzoic acid.
    Type: Application
    Filed: January 16, 2020
    Publication date: July 16, 2020
    Applicant: Monsanto Technology LLC
    Inventors: John H. Ahn, Kam-To Wan
  • Publication number: 20200223785
    Abstract: A process to convert the cyclic monourea of ethylene amine compounds (U-EA) into ethylene amine compound (EA) is provided. The process may include performing a reactive separation step using a reaction mixture containing the cyclic monourea, wherein one cyclic monourea (U-EA) reacts with another cyclic monourea (U-EA) to transfer its urea unit thereto. The process may further include separating the obtained ethylene amine compound (EA) without urea unit from the reaction mixture.
    Type: Application
    Filed: August 7, 2018
    Publication date: July 16, 2020
    Applicant: NOURYON CHEMICALS INTERNATIONAL B.V.
    Inventors: Michiel Jozef Thomas RAAIJMAKERS, Antoon Jacob Berend TEN KATE, Eike Nicolas KANTZER, Rens VENEMAN, Slavisa JOVIC, Rolf Krister EDVINSSON, Karl Fredrik LAKE, Hendrik VAN DAM, Ina EHLERS, Sara Erika TÖNNERFORS
  • Publication number: 20200223786
    Abstract: The present invention relates to a process for the in situ preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine with maleic acid and then with 2-halocarboxylic acid, mixtures obtainable using said process and mixtures of chelating agents. In addition, the invention relates to methods where such mixtures are used.
    Type: Application
    Filed: June 27, 2018
    Publication date: July 16, 2020
    Applicant: Kemira Oyj
    Inventors: Reijo AKSELA, Jonas KONN, Anna-Maija PERANDER, Anna HAARALA, Riitta ILMONIEMI, Hanna HOFFREN
  • Publication number: 20200223787
    Abstract: The present invention relates to a method for purifying polyaspartic acid ester compositions and to the provision of polyaspartic acid ester compositions that contain 0.01 to <2% by weight fumaric acid dialkyl esters.
    Type: Application
    Filed: September 14, 2018
    Publication date: July 16, 2020
    Inventors: Dorota Greszta-Franz, Christian Drumm, Jan Morbach, Reiner Witkowski
  • Publication number: 20200223788
    Abstract: The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of A?42 oligomers in a subject. It further provides a method of reducing formation of or disrupting A?42 oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.
    Type: Application
    Filed: March 31, 2020
    Publication date: July 16, 2020
    Inventors: Ambuj K. Singh, Christian A. Lang
  • Publication number: 20200223789
    Abstract: The present disclosure discloses a rosin-based small molecular weight hydrogelator and an application thereof, and belongs to the fields of supramolecular chemistry, surfactant science and chemical utilization of rosin. The rosin-based small molecular hydrogel of the present disclosure can gel water at a very low concentration, and the critical gelling concentration is only 0.176 wt %. On average, each gelling agent molecule can hold 13,889 water molecules, which exhibits extremely high gel efficiency and the formed small molecular hydrogel also exhibits extremely high stability. This small molecule hydrogel is derived from the natural product rosin and has a mild nature. It can be used in the fields of drug sustained-release, tissue engineering, daily chemicals, medicine and so on.
    Type: Application
    Filed: March 27, 2020
    Publication date: July 16, 2020
    Inventors: Binglei SONG, Tingting YAN, Danping WANG, Zhenggang CUI
  • Publication number: 20200223790
    Abstract: Improved iminium based processes for the production of cyanoacrylates and methylidene malonates wherein the improvement pertains to the presence of acid chlorides and/or acid anhydrides in the reaction mix.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 16, 2020
    Applicant: OptMed, Inc.
    Inventors: Vijaya Bhasker Gondi, John Gregory Reid
  • Publication number: 20200223791
    Abstract: Disclosed are crystalline polymorphs of Bardoxolone methyl, and pharmaceutical compositions thereof.
    Type: Application
    Filed: July 12, 2018
    Publication date: July 16, 2020
    Inventors: Ivana LANDEKA, Helena CERIC
  • Publication number: 20200223792
    Abstract: The present invention relates to a process for the production of alkane sulfonic acid with a regulator as well as two specific compounds which can be used as regulator in a respective process.
    Type: Application
    Filed: June 28, 2018
    Publication date: July 16, 2020
    Applicant: BASF SE
    Inventor: Timo OTT
  • Publication number: 20200223793
    Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.
    Type: Application
    Filed: October 17, 2019
    Publication date: July 16, 2020
    Inventors: Jiasheng LU, Jiamin GU, Xinyong LV, Guowei SONG, Dongdong WU, Daiqiang HU, Jun GU, Gang CHEN, Xiang JI, Xiuchun ZHANG, Jinchao AI, Xianqi KONG
  • Publication number: 20200223794
    Abstract: Substituted hydroquinones and quinones and methods of synthesizing such compounds are disclosed herein. The substituted hydroquinones have the formula: while the substituted quinones have the corresponding oxidized structure (1,4-benzoquinones). One, two, three, or all four of R1, R2, R3 and R4 comprise a thioether moiety and a sulfonate moiety, and wherein each R1, R2, R3 and R4 that does not comprise a thioether and a sulfonate moiety sulfonate moiety is independently a hydrogen, an alkyl or an electron withdrawing group. The substituted hydroquinones and quinones are soluble in water, stable in aqueous acid solutions, and have a high reduction potential in the oxidized form. Accordingly, they can be used as redox mediators in emerging technologies, such as in mediated fuel cells or organic-mediator flow batteries.
    Type: Application
    Filed: March 18, 2020
    Publication date: July 16, 2020
    Inventors: Shannon S. Stahl, James B. Gerken
  • Publication number: 20200223795
    Abstract: Described are a salt and a resist composition capable of producing a resist pattern with satisfactory line edge roughness (LER). The salt is represented by formula (I): In formula (I), R1, R2, R3, R4 and R5 each independently represent a halogen atom or a perfluoroalkyl group having 1 to 6 carbon atoms, R6, R7 and R8 each independently represent a halogen atom, a hydroxy group, a fluorinated alkyl group having 1 to 6 carbon atoms or an alkyl group having 1 to 12 carbon atoms, and —CH2— included in the alkyl group may be replaced by —O— or —CO—, m5 represents an integer of 1 to 5, m6 represents an integer of 0 to 3, m7 represents an integer of 0 to 3, m8 represents an integer of 0 to 4, and AI? represents an organic anion.
    Type: Application
    Filed: April 8, 2019
    Publication date: July 16, 2020
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yukako ANRYU, Koji ICHIKAWA
  • Publication number: 20200223796
    Abstract: A novel onium salt of formula (1) and a chemically amplified resist composition comprising the same as a PAG are provided. When processed by photolithography using KrF or ArF excimer laser, EB or EUV, the resist composition has a high sensitivity and reduced acid diffusion and is improved in exposure latitude, MEF, and LWR.
    Type: Application
    Filed: January 15, 2020
    Publication date: July 16, 2020
    Applicant: Shin-Etsu Chemical Co., Ltd.
    Inventors: Masahiro Fukushima, Masaki Ohashi, Kazuhiro Katayama
  • Publication number: 20200223797
    Abstract: Adducts are described, obtainable from the reaction product of a secondary amine and a diketone, with carbon allotropes in which the carbon is sp2 hybridized, such as graphene, graphite, fullerene, carbon nanotubes and the like, and an inorganic oxide-hy-droxide. A process for preparing said adducts is also described.
    Type: Application
    Filed: November 9, 2017
    Publication date: July 16, 2020
    Applicants: PIRELLI TYRE S.p.A., POLITECNICO DI MILANO
    Inventors: Maurizio Stefano GALIMBERTI, Vincenzina BARBERA
  • Publication number: 20200223798
    Abstract: The application relates to a compound of Formula (I): which modulates the activity of ALK or SRPK, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which ALK or SRPK plays a role.
    Type: Application
    Filed: October 30, 2019
    Publication date: July 16, 2020
    Inventors: John HATCHER, Nathanael S. GRAY, Hwan Geun CHOI, Pasi JANNE, Tinghu ZHANG
  • Publication number: 20200223799
    Abstract: Described herein, inter alia, are compositions of HER3 ligands and methods for treating diseases using the same.
    Type: Application
    Filed: September 2, 2016
    Publication date: July 16, 2020
    Inventors: Christopher Novotny, Kevan SHOKAT, Natalia JURA
  • Publication number: 20200223800
    Abstract: A process for producing a cyclic alkylene urea product of Formula I: in which a compound of Formula II and/or Formula III is contacted in a reaction zone with a compound of Formula IV and/or Formula V and in the presence of one or more carbonyl delivering compounds; in which; R1 is -[A-X-]q]R3; R2 is on each occurrence independently selected from H and C1 to C6 alkyl groups which are optionally substituted by one or two groups selected from —OH and —NH2; R3 is on each occurrence independently selected from H and C1 to C6 alkyl groups which are optionally substituted by one or two groups selected from —OH and —NH2; A is on each occurrence independently selected from C1 to C3 alkylene units, optionally substituted by one or more C1 to C3 alkyl groups; X is on each occurrence independently selected from —O—, —NR2—, groups of Formula VI, and groups of Formula VII and p and q are each independently selected from a whole number in the range of from 0 to 8; wherein the compound of Formula I
    Type: Application
    Filed: August 7, 2018
    Publication date: July 16, 2020
    Applicant: NOURYON CHEMICALS INTERNATIONAL B.V.
    Inventors: Antoon Jacob Berend TEN KATE, Karl Fredrik LAKE, Michiel Jozef Thomas RAAIJMAKERS, Rolf Krister EDVINSSON, Jenny Valborg Therese ADRIAN MEREDITH, Rens VENEMAN, Hendrik VAN DAM, Eike Nicolas KANTZER, Ina EHLERS, Slavisa JOVIC
  • Publication number: 20200223801
    Abstract: Provided is a CCR2/CCR5 receptor antagonist and the use thereof in the preparation of a drug for treating diseases associated with the CCR2/CCR5. In particular, disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 11, 2017
    Publication date: July 16, 2020
    Inventors: Yunfu LUO, Yuyong BA, Shuhui CHEN
  • Publication number: 20200223802
    Abstract: Disclosed are a method for preparing an imidazole derivative and crystal form A and crystal form B thereof, and also disclosed is a method for preparing a compound of formula (I) and an intermediate thereof.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 16, 2020
    Applicant: SHANDONG DANHONG PHARMACEUTICAL CO., LTD.
    Inventors: Weihua SHI, Feng XU, Zheng WANG, Weidong LI, Linghui WU, Hongwei LI, Minggao ZENG, Kunmin LAI, Zhigan JIANG, Haiying HE
  • Publication number: 20200223803
    Abstract: Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases (TgCDPKs) or C. parvum and C. hominus calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula, wherein the variables X, Y, Z, L, R1, and R3 are defined herein.
    Type: Application
    Filed: January 10, 2020
    Publication date: July 16, 2020
    Inventors: Wesley C. Van Voorhis, Wilhelmus G.J. Hol, Eric T. Larson, Dustin James Maly, Ethan Merritt, Kayode K. Ojo
  • Publication number: 20200223804
    Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-III crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).
    Type: Application
    Filed: September 27, 2018
    Publication date: July 16, 2020
    Applicant: NIPPON SHINYAKU CO., LTD.
    Inventor: Toshio FUJIWARA
  • Publication number: 20200223805
    Abstract: Disclosed herein is a two-piece sensor assembly that includes an attachment collar configured to attach to a body surface of a patient and comprising at least one opening, and a skin sensor configured to seat into the at least one opening in the attachment collar. The skin sensor includes at least one radiation source configured to irradiate the body surface with at least one interrogation light, and at least one detector configured to detect at least one response light incident from the direction of the body surface.
    Type: Application
    Filed: August 27, 2019
    Publication date: July 16, 2020
    Inventors: Anthony Le, Martin Leugers
  • Publication number: 20200223806
    Abstract: The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(?O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(?O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(?O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 16, 2020
    Applicant: NIPPON CHEMIPHAR CO., LTD
    Inventors: Masatoshi USHIODA, Kunio KOBAYASHI, Daisuke SAITO, Shogo SAKUMA, Toshiyasu IMAI, Kazuhide INOUE
  • Publication number: 20200223807
    Abstract: The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I:
    Type: Application
    Filed: January 13, 2020
    Publication date: July 16, 2020
    Inventors: Malcolm James Boyce, Liv Thomsen, Donald Alan Gilbert, David Wood
  • Publication number: 20200223808
    Abstract: The present technology provides aryl or heteroaryl triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The aryl or heteroaryl triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).
    Type: Application
    Filed: December 19, 2019
    Publication date: July 16, 2020
    Inventors: Tae Dong HAN, Hee Jae TAK, Eun Kyung KIM, Su Bin CHOI, Dong Hoon KIM, Sol PARK, Eun Hye JUNG, Hyun Ho CHOI, Tae Wang KIM, Mi Kyeong JU, Na Ry HA
  • Publication number: 20200223809
    Abstract: An anthracene material, an organic light emitting diode using the same, and a method for manufacturing the same, are provided. The organic light emitting diode includes a substrate, a first conducting layer, a hole transport layer, a light emitting layer, an electron transport layer, and a second conducting layer. The first conducting layer is disposed on the substrate. The hole transport layer is disposed on the first conducting layer. The light emitting layer having the anthracene material is disposed on the hole transport layer. The electron transport layer is disposed on the light emitting layer. The second conducting layer is disposed on the electron transport layer.
    Type: Application
    Filed: January 10, 2020
    Publication date: July 16, 2020
    Applicants: Yuan Ze University, Nichem Fine Technology Co, Ltd., Wisechip Semiconductor Inc., Tetrahedron Technology Corporation, Shine Materials Technology Co., Ltd.
    Inventors: Tien-Lung Chiu, Jiun-Haw Lee, Man-kit Leung, Chi-Feng Lin, Zheng-Chen Hsiao, Yi-Mei Huang, Bo-An Fan
  • Publication number: 20200223810
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
    Type: Application
    Filed: December 12, 2019
    Publication date: July 16, 2020
    Inventors: Daniel J. Canney, Benjamin E. Blass, Rong Gao, Magid Abou-Gharbia
  • Publication number: 20200223811
    Abstract: The disclosure relates to an efficient process for the production of a furan derivative from C5 and/or C6 sugars. The process utilizes a water immiscible organic solvent system comprising at least one alkyl phenol and at least one alkylated naphthalene.
    Type: Application
    Filed: March 13, 2020
    Publication date: July 16, 2020
    Inventors: Keith W. Hutchenson, Torren Ryan Carlson, Jacob G. Dickinson, David William Drew, Paul Joseph Fagan, Francis G. Gallagher, Isabel Liberis, Kenneth Mersman, Gregg Sunshine
  • Publication number: 20200223812
    Abstract: The present disclosure provides processes for the purification of 2,5-furandicarboxylic acid (FDCA). The present disclosure further provides crystalline preparations of purified FDCA, as well as processes for making the same. In addition, the present disclosure provides mixtures used in processes for the purification of FDCA.
    Type: Application
    Filed: July 11, 2018
    Publication date: July 16, 2020
    Inventors: Henricus Johannes Cornelis Den Ouden, Valery Sokolovskii, Thomas R. Boussie, Gary M. Diamond, Eric L. Dias, Guang Zhu, Staffan Torssell, Vincent J. Murphy
  • Publication number: 20200223813
    Abstract: The invention provides compounds of formula (I) or salts thereof: wherein: A, B, C, D, W, X, Y and Z are as defined in the specification, and at least one of A, B, C, D, W, X, Y and Z is OR1; each R1 being independently H or C(?O)R2, and at least one R1 group being C(?O)R2; where each R2 is selected from: CHR3NHR4, where R4 is H and R3 is a group selected from CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, CH2Ph, CH2-3-(1H-indole), CH2CH2SCH3, CH2OH, CHOHCH3, CH2SH, CH2SeH and CH2PhpOH, wherein said R3 group can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C4 alkyl; or R3 and R4 together with the C and N atoms to which they are attached form a 5-membered heteroalkyl ring, wherein said heteroalkyl ring can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C3 alkyl, wherein RA is C1-C4 alkyl optionally substituted with one or more halogen, cyano or nitro groups.
    Type: Application
    Filed: January 13, 2020
    Publication date: July 16, 2020
    Inventors: Christopher Rinsch, Rune A. Ringom
  • Publication number: 20200223814
    Abstract: The present invention is directed to methods of producing THC from CBD utilizing non-harsh methodology and resulting in substantially increased yields, as well as devices built upon these novel methods. The methods and devices are material efficient, and in certain embodiments, solvent-free. In particular, in certain embodiments, these methods and related devices are suitable for commercial production of THC from CBD. Furthermore, in certain embodiments, the present invention provides methods of producing THC from CBD in manner that affords tunability to select the ratio of THC-8 to THC-9.
    Type: Application
    Filed: January 13, 2020
    Publication date: July 16, 2020
    Inventor: Alex Nivorozhkin
  • Publication number: 20200223815
    Abstract: Disclosed are compounds, for example, compounds of formula I, wherein R, R0, R1-R8, n, X, Y, Y?, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.
    Type: Application
    Filed: March 30, 2020
    Publication date: July 16, 2020
    Applicant: ADT Pharmaceuticals, LLC
    Inventors: Gary A. Piazza, Xi Chen, Adam B. Keeton, Michael R. Boyd
  • Publication number: 20200223816
    Abstract: Disclosed are compounds, for example, compounds of formula I, wherein R, R0, R1-R8, n, X, Y, Y?, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.
    Type: Application
    Filed: March 30, 2020
    Publication date: July 16, 2020
    Applicant: ADT Pharmaceuticals, LLC
    Inventors: Gary A. Piazza, Xi Chen, Adam B. Keeton, Michael R. Boyd
  • Publication number: 20200223817
    Abstract: Disclosed are compounds, for example, a compound of formula I, wherein R, R0, R1-R8, n, X, Y, Y?, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.
    Type: Application
    Filed: April 1, 2020
    Publication date: July 16, 2020
    Applicant: ADT Pharmaceuticals, LLC
    Inventors: Gary A. Piazza, Xi Chen, Adam B. Keeton, Michael R. Boyd
  • Publication number: 20200223818
    Abstract: Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds.
    Type: Application
    Filed: December 12, 2019
    Publication date: July 16, 2020
    Inventors: Mitchell A. deLong, Jill Marie Sturdivant, Susan M. Royalty
  • Publication number: 20200223819
    Abstract: There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3 and X have meanings provided in the description, which compounds are useful in the treatment of cancers.
    Type: Application
    Filed: February 7, 2018
    Publication date: July 16, 2020
    Inventors: Benjamin Pelcman, Edgars Suna, William Stafford, Martins Priede
  • Publication number: 20200223820
    Abstract: Provided is compound of formula (I): where: X and Y may be identical or different and represent O, NH, or S; R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 may be identical or different and represent H, halogen, CN, NO2, (C1-4)alkyl, (C1-4)haloalkyl, (C2-4)alkenyl, OH, O(C1-4)alkyl, O(C1-4)haloalkyl, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, CHO, C2-4alkenyl substituted with CN, C2-4alkenyl substituted with COOH, C2-4alkenyl substituted with CHO, or C2-4alkenyl substituted with OH; RA and RB may be identical or different and represent H, (C1-4)alkyl, (C1-4)haloalkyl, or (C2-4)alkenyl; A1, A2, A3, and A4 may be identical or different and represent CH or N with the proviso that A1 and A2 cannot be N and that R5 and R10 are absent when A3 and A4 are N; or a pharmaceutically acceptable salt thereof, stereoisomer thereof, or mixture comprising stereoisomers thereof.
    Type: Application
    Filed: August 29, 2017
    Publication date: July 16, 2020
    Applicants: CHULABHORN FOUNDATION, KASETSART UNIVERSITY, SRINAKHARINWIROT UNIVERSITY
    Inventors: Supanna TECHASAKUL, Arthit MAKARASEN, Nanthawan REUK-NGAM, Panita KHLAYCHAN, Mayuso KUNO, Supa HANNONGBUA
  • Publication number: 20200223821
    Abstract: The present disclosure relates to a novel phenylpyridine derivative represented by Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers.
    Type: Application
    Filed: October 11, 2018
    Publication date: July 16, 2020
    Inventors: Wol-Young Kim, Jung-eun Park, Keuk-Chan Bang, Joon-Seok Park