Publication number: 20200223813
Abstract: The invention provides compounds of formula (I) or salts thereof: wherein: A, B, C, D, W, X, Y and Z are as defined in the specification, and at least one of A, B, C, D, W, X, Y and Z is OR1; each R1 being independently H or C(?O)R2, and at least one R1 group being C(?O)R2; where each R2 is selected from: CHR3NHR4, where R4 is H and R3 is a group selected from CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, CH2Ph, CH2-3-(1H-indole), CH2CH2SCH3, CH2OH, CHOHCH3, CH2SH, CH2SeH and CH2PhpOH, wherein said R3 group can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C4 alkyl; or R3 and R4 together with the C and N atoms to which they are attached form a 5-membered heteroalkyl ring, wherein said heteroalkyl ring can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C3 alkyl, wherein RA is C1-C4 alkyl optionally substituted with one or more halogen, cyano or nitro groups.
Type:
Application
Filed:
January 13, 2020
Publication date:
July 16, 2020
Inventors:
Christopher Rinsch, Rune A. Ringom
Publication number: 20200223820
Abstract: Provided is compound of formula (I): where: X and Y may be identical or different and represent O, NH, or S; R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 may be identical or different and represent H, halogen, CN, NO2, (C1-4)alkyl, (C1-4)haloalkyl, (C2-4)alkenyl, OH, O(C1-4)alkyl, O(C1-4)haloalkyl, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, CHO, C2-4alkenyl substituted with CN, C2-4alkenyl substituted with COOH, C2-4alkenyl substituted with CHO, or C2-4alkenyl substituted with OH; RA and RB may be identical or different and represent H, (C1-4)alkyl, (C1-4)haloalkyl, or (C2-4)alkenyl; A1, A2, A3, and A4 may be identical or different and represent CH or N with the proviso that A1 and A2 cannot be N and that R5 and R10 are absent when A3 and A4 are N; or a pharmaceutically acceptable salt thereof, stereoisomer thereof, or mixture comprising stereoisomers thereof.
Type:
Application
Filed:
August 29, 2017
Publication date:
July 16, 2020
Applicants:
CHULABHORN FOUNDATION, KASETSART UNIVERSITY, SRINAKHARINWIROT UNIVERSITY
Inventors:
Supanna TECHASAKUL, Arthit MAKARASEN, Nanthawan REUK-NGAM, Panita KHLAYCHAN, Mayuso KUNO, Supa HANNONGBUA