Publication number: 20200223823
Abstract: A main object of the present invention is to provide new crystals of (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate (hereinafter, referred to as “compound A”). A Form-I crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.4 degrees, 12.5 degrees, 15.1 degrees, 16.4 degrees, 18.3 degrees, 19.0 degrees, 24.9 degrees, 25.4 degrees, 27.3 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.54 ?). A Form-II crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.2 degrees, 12.4 degrees, 14.8 degrees, 16.5 degrees, 18.1 degrees, 18.5 degrees, 19.8 degrees, 23.6 degrees, 24.9 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.
Type:
Application
Filed:
September 27, 2018
Publication date:
July 16, 2020
Applicant:
NIPPON SHINYAKU CO., LTD.
Inventors:
Toshio FUJIWARA, Joanna BIS, Senthil Kumar Kusalakumari SUKUMAR
Publication number: 20200223852
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
Type:
Application
Filed:
July 19, 2018
Publication date:
July 16, 2020
Inventors:
Burcu Selin Aytar, Alina Borovika, Collin Chan, Joerg Deerberg, Nathan R. Domagalski, Martin D. Eastgate, Yu Fan, Michael David Bengt Fenster, Robert V. Forest, Francisco Gonzalez-Bobes, Rebecca A. Green, Matthew R. Hickey, Nathaniel David Kopp, Thomas E. La Cruz, Kathleen Lauser, Hong Geun Lee, David K. Leahy, Helen Y. Luo, Thomas M. Razler, Scott A. Savage, Chris Sfouggatakis, Maxime C.D. Soumeillant, Serge Zaretsky, Bin Zheng, Ye Zhu