Patents Issued in July 21, 2020
-
Patent number: 10717673Abstract: Provided are cementitious mixtures and processes for reinforcing a cementitious matrix. In one form of the process for reinforcing a cementitious matrix includes the steps of mixing a mineral cement and one or more populations of synthetic copolymer microfibers including about 1 mol. % to about 25 mol. % and from about 75 mol. % to about 99.5 mol. % of propylene monomeric units.Type: GrantFiled: October 25, 2018Date of Patent: July 21, 2020Assignee: ExxonMobil Research and Engineering CompanyInventor: Jevan Furmanski
-
Patent number: 10717674Abstract: The invention is directed to compositions and methods for the manufacture of pigmented solids structures for which can be used for construction and/or decoration. Manufacturing comprises fixing one or more pigments to an aggregate material such as crushed rock, stone or sand. The pigmented aggregate is incubated with urease or urease producing microorganisms, an amount of a nitrogen source such as urea, and an amount of calcium source such as calcium chloride forming calcite bridges between particles of aggregate. The resulting solid has a hardness and colorfastness for most any construction material. Using selected aggregate and pigment, the process also provides for the manufacture of simulated-stone materials such as clay or granite bricks or blocks, marble counter-tops, and more. The invention is also directed to composition containing microorganisms and pigment as kits that can be added to most any aggregate materials.Type: GrantFiled: March 10, 2017Date of Patent: July 21, 2020Assignee: BioMason, Inc.Inventors: Thomas A. Hill, Steven W. McAllister, J. Michael Dosier, Ginger K. Dosier
-
Patent number: 10717675Abstract: Disclosed is a hydraulically and chemically bonding refractory cement, which includes a caustic magnesia component having a BET specific surface area of at least 0.5 m2/g, and a carboxylic acid component, wherein the carboxylic acid component consists of at least one carboxylic acid that is only slightly water soluble and/or has a low dissolution rate in aqueous solutions, and which carboxylic acid component is capable of generating at least one soluble magnesium salt upon contact of the cement with water. Also disclosed is a corresponding refractory material containing the magnesia cement and to uses thereof for the manufacture of products useful in various industries.Type: GrantFiled: November 29, 2016Date of Patent: July 21, 2020Assignee: KERNEOSInventor: Jerzy Bugajski
-
Patent number: 10717676Abstract: The present specification discloses ceramic matrix compositions, methods of making such ceramic matrix compositions and methods and uses for such ceramic matrix compositions.Type: GrantFiled: February 1, 2019Date of Patent: July 21, 2020Assignee: Nano Evaporative Technologies, Inc.Inventor: Jonathan S. Harms
-
Patent number: 10717677Abstract: A method for producing a transparent alumina sintered body according to the present invention includes (a) a step of preparing an alumina raw material powder containing a plate-like alumina powder having an aspect ratio of 3 or more and a fine alumina powder having an average particle diameter smaller than that of the plate-like alumina powder so that, when a mixing ratio of the plate-like alumina powder to the fine alumina powder in terms of mass ratio is assumed to be T:(100?T), T is 0.001 or more and less than 1, and so that a mass ratio R1 of F relative to Al in the alumina raw material powder is less than 15 ppm; (b) a step of forming a raw material for forming containing the alumina raw material powder into a compact; and (c) a step of sintering the compact so as to obtain a transparent alumina sintered body.Type: GrantFiled: February 23, 2018Date of Patent: July 21, 2020Assignee: NGK Insultators, Ltd.Inventors: Morimichi Watanabe, Kiyoshi Matsushima, Kei Sato, Tsutomu Nanataki
-
Patent number: 10717678Abstract: A coating including a bond layer deposited on a substrate. The bond layer includes a rare earth silicate and a second phase, the second phase including at least one of silicon, silicides, alkali metal oxides, alkali earth metal oxides, glass ceramics, Al2O3, TiO2, Ta2O5, HfO2, ZrO2, HfSiO4, ZrSiO4, HfTiO4, ZrTiO4, or mullite. The coating may provide thermal and/or environmental protection for the substrate, especially when the substrate is a component of a high-temperature mechanical system.Type: GrantFiled: September 29, 2009Date of Patent: July 21, 2020Assignee: Rolls-Royce CorporationInventor: Kang N. Lee
-
Patent number: 10717679Abstract: There is provided a platy zinc oxide sintered compact containing 0.80 wt % or less at least one first dopant element selected from the group consisting of Al, Ga and In, the balance consisting essentially of ZnO and optionally at least one second dopant element selected from the group consisting of Br, Cl, F, Sn, Y, Pr, Ge, B, Sc, Si, Ti, Zr, Hf, Mn, Ta, W, Cu, Ni, Cr, La, Gd, Bi, Ce, Sr and Ba, the second dopant element being optional component, wherein the (002)-plane orientation in the plate surface is 60% or more. The zinc oxide sintered compact of the present invention has excellent properties such as high orientation in addition to transparency and conductivity.Type: GrantFiled: January 30, 2017Date of Patent: July 21, 2020Assignee: NGK Insulators, Ltd.Inventors: Sota Okochi, Jun Yoshikawa, Koichi Kondo
-
Patent number: 10717680Abstract: A method of fabricating a ceramic article includes providing a porous body that includes a plurality of fiber bundles that has an intra-bundle porosity and an inter-bundle porosity, infiltrating the intra-bundle porosity and the inter-bundle porosity with a mixture of particles in a liquid carrier, the particles having an average size selected with respect to at least the intra-bundle porosity, removing the liquid carrier from the porous body to deposit the particles in the intra-bundle porosity and in the inter-bundle porosity, infiltrating a preceramic polymer into a remaining intra-bundle porosity and a remaining inter-bundle porosity, and thermally converting the preceramic polymer to a ceramic material.Type: GrantFiled: March 29, 2018Date of Patent: July 21, 2020Assignee: RAYTHEON TECHNOLOGIES CORPORATIONInventors: Shahram Amini, Xia Tang, Wayde R. Schmidt, Tania Bhatia Kashyap
-
Patent number: 10717681Abstract: A method of preparing a ceramic matrix composite (CMC) component that includes a protective ceramic layer comprises adhering at least one flexible ceramic tape to a ceramic fiber preform, where the at least one flexible ceramic tape comprises ceramic particles dispersed in an organic binder phase. After the adhering, the at least one flexible ceramic tape is heated to a temperature sufficient to volatilize the organic binder phase, thereby forming a porous ceramic layer on at least a portion of the ceramic fiber preform. After the heating and volatilizing, the ceramic fiber preform and the porous ceramic layer are infiltrated with a molten material, thereby forming a CMC component including, on at least a portion thereof, a protective ceramic layer.Type: GrantFiled: December 3, 2015Date of Patent: July 21, 2020Assignee: ROLLS-ROYCE CORPORATIONInventors: Sean Erin Landwehr, Benjamin John Bowin Lai, Adam Lee Chamberlain
-
Patent number: 10717682Abstract: A granular fertilizer product having at least two sources of boron having different solubilities to tailor boron availability during the entire growing season of a plant, while reducing the risk of boron toxicity. A first source of boron can include a sodium-based or highly water soluble boron compound such as sodium tetraborate and/or boric acid, while a second source of boron can include a calcium-based boron compound such as colemanite (CaB3O4(OH)3.(H2O)) (e.g. when the carrier fertilizer is N- or K-based) and/or boron phosphate (BPO4) (e.g. when the carrier fertilizer is P-based). The solubility of the first source of boron is higher than the solubility of the second source of boron such that the sources of boron have different release rates into the soil.Type: GrantFiled: April 2, 2018Date of Patent: July 21, 2020Assignee: The Mosaic CompanyInventors: Michael McLaughlin, Jozefien Degryse, Roslyn Baird, Rodrigo Coqui da Silva, Kyle Freeman, Thomas Fry
-
Patent number: 10717683Abstract: A housing for a worm farm includes a composting cavity that, in use of the housing, is to contain worms, bedding material and/or organic waste, the composting cavity being defined by a floor having openings through which castings can pass, and one or more side walls that extend around the floor. A support structure supports the floor and the side walls above a ground surface. A cover locates on the side walls and extend over the composting cavity, and is movable to enable access to the composting cavity. A castings receptacle is movable between an operative position and at least one displaced position.Type: GrantFiled: May 13, 2016Date of Patent: July 21, 2020Assignee: HANDELA PTY LTDInventor: Tony McCarthy
-
Patent number: 10717684Abstract: The invention relates to methods and apparatuses for producing Class A biosolids. In yet another embodiment, the invention relates to a method comprising digesting waster material by anaerobic digestion, and yielding Class A biosolids. In still yet another embodiment, the invention relates to a system for anaerobic digestion of waste material to produce Class A biosolids. In still yet another embodiment, the invention relates to a system for anaerobic digestion of waste material comprising a mixing chamber, a digester, a heating pit, and an effluent pit.Type: GrantFiled: September 10, 2014Date of Patent: July 21, 2020Assignee: DVO LICENSING, INC.Inventor: Stephen W. Dvorak
-
Patent number: 10717685Abstract: A multispectral smoke obscurant composition effective in reducing transmittance in the visual, infrared, and ultraviolet regions of the electromagnetic spectrum, comprising at least one metal organic framework (“MOF”), at least one fuel, at least one oxidizer, and optionally one or more additives selected from the group consisting of binders, coolants, and accelerants. The MOF or MOF composite is present from about 10 to 90 weight percent of the smoke obscurant composition, while the fuel and the oxidizer in combination comprise about at least 10 weight percent of the smoke obscurant composition.Type: GrantFiled: April 18, 2019Date of Patent: July 21, 2020Assignee: The United States of America as Represented by the Secretary Of the ArmyInventors: Amee L Polk, Zachary B Zander, Danielle L Kuhn, Gregory W Peterson, Jared B DeCoste
-
Patent number: 10717686Abstract: The present invention pertains generally toward an easier and more efficient way to burn Palo Santo wood for aromatherapy, and more particularly toward a self-lighting match stick made of Palo Santo wood. In the present invention, the wood of Palo Santo is turned into match stick by covering the small sticks of Palo Santo with paraffin wax and match head solution. The present invention enables easy ignition of the Palo Santo wood by the user for aromatherapy and makes the process hassle free.Type: GrantFiled: May 11, 2018Date of Patent: July 21, 2020Inventor: Maxwell Rennie
-
Patent number: 10717687Abstract: Paraffin compositions including mainly even carbon number paraffins, and a method for manufacturing the same, is disclosed herein. In one embodiment, the method involves contacting naturally occurring fatty acid/glycerides with hydrogen in a slurry bubble column reactor containing bimetallic catalysts with equivalent particle diameters from about 10 to about 400 micron. The even carbon number compositions are particularly useful as phase change material.Type: GrantFiled: May 7, 2018Date of Patent: July 21, 2020Assignee: REG SYNTHETIC FUELS, LLCInventors: Ramin Abhari, H. Lynn Tomlinson, Vladimir Gruver
-
Patent number: 10717688Abstract: The present invention relates to a process for producing benzene from a mixed hydrocarbon feedstream comprising subjecting C6 cut separated from said mixed hydrocarbon feedstream to aromatization to provide a benzene-rich aromatic stream and recovering the benzene from the benzene-rich aromatic stream.Type: GrantFiled: June 25, 2015Date of Patent: July 21, 2020Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Scott Stevenson, Dimitri Daniëls
-
Patent number: 10717689Abstract: The present invention relates to the provision of an organic compound or compounds containing a fluorenone derivative structure or its substituted derivatives to enhance the thermal stability of organic solar cells.Type: GrantFiled: August 29, 2017Date of Patent: July 21, 2020Assignee: Hong Kong Baptist UniversityInventors: Beng Soon Ong, Yong Lu, Carr Hoi Yi Ho, Huanyang Cao, Sin Hang Cheung, Ka Lok Chiu, Shu Kong So
-
Patent number: 10717690Abstract: Provided is a method of manufacturing octafluorocyclopentene by bringing 1-chloroheptafluorocyclopentene into contact with an alkali metal fluoride. The manufacturing method includes a feedstock heating step of heating 1-chloroheptafluorocyclopentene to not lower than 40° C. and not higher than 55° C. and a fluorination step of maintaining a suspension containing a polar aprotic solvent and an alkali metal fluoride at 85° C. or higher while supplying heated 1-chloroheptafluorocyclopentene into the suspension and performing fluorination thereof to obtain octafluorocyclopentene.Type: GrantFiled: June 1, 2018Date of Patent: July 21, 2020Assignee: ZEON CORPORATIONInventor: Tatsuya Sugimoto
-
Patent number: 10717691Abstract: The present invention relates to a process for the production of semifluorinated alkanes.Type: GrantFiled: May 4, 2018Date of Patent: July 21, 2020Assignee: NOVALIQ GMBHInventor: Lorenz Lörsch
-
Patent number: 10717692Abstract: A process for the production of 2-alkylalkanol from an aldehyde is disclosed.Type: GrantFiled: October 12, 2017Date of Patent: July 21, 2020Assignee: Johnson Matthey Davy Technologies LimitedInventors: Adrian Lord, Martin Smidt
-
Patent number: 10717693Abstract: The present invention provides a method for producing a diol having a specific structure in high yields while keeping high selectivity. Provided is a method for producing a diol having a specific structure by oxidizing an olefin having a specific structure in the presence of a ruthenium compound.Type: GrantFiled: November 22, 2016Date of Patent: July 21, 2020Assignee: DAIKIN INDUSTRIES, LTD.Inventors: Tomohito Hamada, Michiaki Okada, Akinori Yamamoto, Yosuke Kishikawa
-
Patent number: 10717694Abstract: A hydrofluoroolefin compound is represented by the following general formula (I): where Rf is a linear or branched perfluorinated alkyl group containing 2-10 carbon atoms and optionally contains (i) at least one catenated heteroatom selected from O or N; or (ii) a ring structure having 3 to 6 ring carbon atoms that optionally contains one or more catentated heteroatoms selected from O or N.Type: GrantFiled: May 1, 2017Date of Patent: July 21, 2020Assignee: 3M Innovative Properties CompanyInventors: Sean M. Smith, William M. Lamanna, Michael G. Costello, Michael J. Bulinski
-
Patent number: 10717695Abstract: Provided are integrated processes for the conversion of beta propiolactone to acrylic acid. Systems for the production of acrylic acid are also provided.Type: GrantFiled: August 21, 2018Date of Patent: July 21, 2020Assignee: Novomer, Inc.Inventor: Sadesh H. Sookraj
-
Patent number: 10717696Abstract: Methods for making acrylic acid, acrylic acid derivatives, or mixtures thereof by contacting a feed stream containing lactic acid, lactic acid derivatives, or mixtures thereof with a molten salt catalyst comprising an ionic liquid (IL) and an acid in liquid phase are provided.Type: GrantFiled: July 27, 2017Date of Patent: July 21, 2020Assignee: The Procter & Gamble CompanyInventors: Jakob Albert, Peter Wasserscheid, Nicola Taccardi, Jens Nagengast, Matthias Kehrer, Julian Kadar, Dimitris Ioannis Collias
-
Patent number: 10717697Abstract: The present invention relates to a method for preparing 1,3-cyclohexanedicarboxylic acid capable of exhibiting excellent activity, of enhancing the reaction efficiency and economic efficiency by using a catalyst having improved durability under the reaction conditions of high temperature and strong acid, of achieving excellent conversion rates by allowing most of reactants to participate in the reaction, and of obtaining products having high purity while minimizing by-products within a shorter period of time. The method for preparing 1,3-cyclohexanedicarboxylic acid may include: reducing isophthalic acid in the presence of a metal catalyst fixed to a silica support and containing a palladium (Pd) compound and a copper (Cu) compound in a weight ratio of 1:0.1 to 0.5.Type: GrantFiled: September 27, 2017Date of Patent: July 21, 2020Assignee: LOTTE CHEMICAL CORPORATIONInventors: Sung Min Kim, Mi Sun Cha, Seong Hwan Choi, Young Heon Choi, Sung Joon Park, Chan Yeong Yun, Young Jong Seo
-
Patent number: 10717698Abstract: The present invention relates to compounds of ester derivative of resveratrol, compositions comprising ester derivatives of resveratrol, processes for synthesizing an ester of resveratrol, and use thereof.Type: GrantFiled: March 6, 2017Date of Patent: July 21, 2020Assignee: ELC Management LLCInventors: Fatemeh Mohammadi, Elham Tavasoli
-
Patent number: 10717699Abstract: A compound having the formula (I): (I) is disclosed. A method of preparing the compound of formula (I) is also disclosed.Type: GrantFiled: April 9, 2020Date of Patent: July 21, 2020Assignee: SOUTHWEST UNIVERSITYInventors: Lei Luo, Shinan Jiang, Yonghuang Luo, Han Li, Nan Hui
-
Patent number: 10717700Abstract: The present invention provides a process for nitrating aromatic compounds without the need for a solid catalyst and/or any organic solvents and/or any other additives. A typical process includes combining or admixing a nitric acid and an anhydride compound under conditions sufficient to produce a reactive intermediate. The aromatic compound to be nitrated is then added to this reactive intermediate to produce a nitroaromatic compound. The nitroaromatic compound can be substituted with one or more, typically, one to three, and often one or two nitrate (—NO2) groups.Type: GrantFiled: January 18, 2016Date of Patent: July 21, 2020Assignee: Arizona Board of Regents on behalf of the University of ArizonaInventors: Bhumasamudram Jagadish, Eugene Mash
-
Patent number: 10717701Abstract: Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of ?-dehydroherbac and the scope is demonstrated with a small collection of additional substrates.Type: GrantFiled: April 5, 2018Date of Patent: July 21, 2020Assignee: International Flavors & Fragrences Inc.Inventors: Estela Espinos Ferri, Ana Maria Collado Perez, Ian R. Baxendale, James S. Sharley
-
Patent number: 10717702Abstract: Methods of preparing a polyaspartic ester composition comprise reacting a primary diamine reactant composition with a diester reactant composition under conditions to prepare a polyaspartic ester composition having a primary amine value of less than 35 mg KOH/g wherein, at the time of the reaction, the combined water content of the primary diamine reactant composition and the diester reactant composition is less than 300 ppm. Compositions and methods of use of the compositions are also described.Type: GrantFiled: March 2, 2018Date of Patent: July 21, 2020Assignee: CARGILL, INCORPORATEDInventors: Andrew M. Karl, Todd L. Kurth
-
Patent number: 10717703Abstract: Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.Type: GrantFiled: August 20, 2018Date of Patent: July 21, 2020Assignee: Celgene CorporationInventors: John F. Traverse, Michael J. Zacuto, Weihong Zhang, Kirsten Faye Johnson, Maryll E. Geherty, Christopher Marton
-
Patent number: 10717704Abstract: This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.Type: GrantFiled: April 19, 2019Date of Patent: July 21, 2020Assignee: Rgenix, Inc.Inventors: Eduardo J. Martinez, Sohail F. Tavazoie
-
Patent number: 10717705Abstract: A method for efficiently removing impurities such as sodium ions, fluoride ions, chloride ions and fluorosulfate ions without reducing the yield of a target product, including a fluorine-containing sulfonylamide compound selected from the group consisting of fluorine-containing sulfonylamide, a metal salt thereof, an ammonium salt thereof and a quaternary ammonium salt thereof is washed with an aqueous solution of salt of sulfuric acid.Type: GrantFiled: August 1, 2017Date of Patent: July 21, 2020Assignee: NIPPON SODA CO., LTD.Inventors: Shiro Tsubokura, Yuka Aomori, Satoshi Kako
-
Patent number: 10717706Abstract: An m-phenylenediamine compound is represented by the following General Formula (I), (II), or (III). R1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, or an aryl group. R2, R3, and R4 each represent an alkyl group. R5 and R6 each represent an alkyl group. X represents a chlorine atom or a bromine atom. A method for producing a polymer compound includes obtaining a polymer compound by using the m-phenylenediamine compound represented by General Formula (I) as a raw material.Type: GrantFiled: February 13, 2019Date of Patent: July 21, 2020Assignee: FUJIFILM CorporationInventors: Koji Hironaka, Shohei Kataoka, Masato Senoo, Tetsu Kitamura, Sotaro Inomata, Satoshi Sano, Masatoshi Yumoto
-
Patent number: 10717707Abstract: A method of making CF3CH2SH, comprising a step of reacting CF3CH2X, wherein X is halide or tosylate, with MSH, where M is an alkali metal such as Na or K, to yield CF3CH2SH.Type: GrantFiled: January 3, 2019Date of Patent: July 21, 2020Assignee: Arkema Inc.Inventors: Robert George Syvret, Craig Alan Polsz, Dana Lee Swan, Vijay R. Srinivas
-
Patent number: 10717708Abstract: The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.Type: GrantFiled: December 8, 2016Date of Patent: July 21, 2020Assignee: Bristol-Myers Squibb CompanyInventors: Nicholas R. Wurtz, Pravin Sudhakar Shirude
-
Patent number: 10717710Abstract: The present application provides solid forms of (R)-6-(2-fluorophenyl)-N-(3-(2-(2-methoxyethylamino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine dihydrochloride, and methods of preparing and using same.Type: GrantFiled: January 30, 2019Date of Patent: July 21, 2020Assignee: ArQule, Inc.Inventors: Craig Bates, David P. Reed
-
Patent number: 10717711Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.Type: GrantFiled: February 27, 2019Date of Patent: July 21, 2020Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Adam K. Charnley, Xiaoyang Dong
-
Patent number: 10717712Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.Type: GrantFiled: July 25, 2019Date of Patent: July 21, 2020Assignee: CONCENTRIC ANALGESICS, INC.Inventors: John F. Donovan, Craig Husfeld
-
Patent number: 10717713Abstract: Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals.Type: GrantFiled: September 19, 2018Date of Patent: July 21, 2020Assignee: Lawrence Livermore National Security, LLCInventors: Carlos A. Valdez, Edmond Y. Lau, Brian P. Mayer
-
Patent number: 10717714Abstract: A reactive UV absorber suitable for polyurethane is provided. The reactive UV absorber is a compound of formula 1: wherein R1 is H or Cl.Type: GrantFiled: July 7, 2017Date of Patent: July 21, 2020Assignee: CHITEC TECHNOLOGY CO., LTD.Inventors: Chingfan Chris Chiu, Huang-min Wu, Wei-chun Chang, Chi-feng Wu, Ching-hao Cheng, Shao-hsuan Wu
-
Patent number: 10717715Abstract: Disclosed are solid forms of ingenol 3-(3,5-diethylisoxazole-4-carboxylate) selected from an amorphous form or a crystalline anhydrous form. Also disclosed are solid solvates of ingenol 3-(3,5-diethylisoxazole-4-carboxylate) selected from an acetone solvate, a dimethylcarbonate solvate, an isopropyl ether solvate, an acetonitrile solvate, a toluene solvate, a mesitylene solvate, a nitromethane solvate, a dichloromethane/heptane solvate and an ethyl acetate solvate, for use as intermediates.Type: GrantFiled: August 29, 2017Date of Patent: July 21, 2020Assignee: INDENA S.P.A.Inventors: Pietro Allegrini, Federico Peterlongo, Andrea Gambini, Daniele Ciceri, Nicola Sardone, Maurizio Ricotti
-
Patent number: 10717716Abstract: The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds.Type: GrantFiled: August 4, 2016Date of Patent: July 21, 2020Assignee: Chong Kun Dang Pharmaceutical Corp.Inventors: Jaekwang Lee, Yuntae Kim, Chang Sik Lee, Hyeseung Song, Dal-Yong Gwak, Jaeyoung Lee, Jung Taek Oh, Chang Gon Lee, Il Hyang Kim
-
Patent number: 10717717Abstract: An improved process for producing various types of cannabis extract from harvested cannabis wherein a quantity of harvested cannabis, which typically includes the inflorescence, floral leaves, and small stems of a flowering cannabis plants, is frozen and subjected to cryogenic grinding to produce pulverized cannabis. The pulverized cannabis is then subjected to alcohol extraction to produce an initial cannabis extract which is filtered to yield a remainder fraction and a filtrate. The remainder fraction potentiates the activity of cannabis formulations while the filtrate can be subjected to one of several forms of further processing according to the desired chemical profile of the final product.Type: GrantFiled: September 12, 2019Date of Patent: July 21, 2020Assignee: Jenny's Rose, LLCInventor: James Castillo
-
Patent number: 10717718Abstract: Disclosed are new compounds of formulae: Wherein: R1 and R2 can be independently H; a C1 to C6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R1,R2 together with the carbon C-6 can be a cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R3 can be a C1 to C6 alkyl including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N3, Kdo-N3 and 4eKdo-N3.Type: GrantFiled: November 16, 2016Date of Patent: July 21, 2020Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Boris Vauzeilles, Jordi Mas Pons, Aurèlie Baron
-
Patent number: 10717719Abstract: Processes for producing ethylene carbonate and/or ethylene glycol, and associated reaction systems are similarly provided. Specifically, a process is provided that comprises supplying an overhead absorber stream withdrawn from an absorber to a vapor-liquid separator to yield an aqueous bottoms stream and a recycle gas stream; supplying an aqueous process stream comprising one or more impurities to a distillation apparatus to yield an overhead impurities stream and a purified aqueous process stream; supplying at least a portion of the purified aqueous process stream and an ethylene oxide product stream to the absorber; and contacting the ethylene oxide product stream with the purified aqueous process stream in the absorber in the presence of one or more carboxylation and hydrolysis catalysts to yield a fat absorbent stream comprising ethylene carbonate and/or ethylene glycol.Type: GrantFiled: April 10, 2017Date of Patent: July 21, 2020Assignee: Shell Oil CompanyInventors: Jesse Raymond Black, Roel Guillaume Hubertus Leonardus Bastings, Alexandre Molina
-
Patent number: 10717720Abstract: The present disclosure discloses a modified compound of andrographolide, and particularly discloses a compound shown in formula (I) and (II) or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 22, 2016Date of Patent: July 21, 2020Assignees: Heilongjiang Zhenbaodao Pharmaceutical Co., Ltd., Medshine Discovery Inc.Inventors: Haiying He, Zhigan Jiang, Jianhua Xia, Jing Wang, Lixia Han, Lihong Lan, Hui Zhou, Kunmin Lai, Shuhui Chen
-
Patent number: 10717721Abstract: Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor.Type: GrantFiled: December 21, 2018Date of Patent: July 21, 2020Assignee: Helsinn Healthcare SAInventors: Luca Fadini, Peter Manini, Claudio Pietra, Claudio Giuliano, Emanuela Lovati, Roberta Cannella, Alessio Venturini, Valentino J. Stella
-
Patent number: 10717722Abstract: The aryl sulfonamide compounds of this invention have powerful and cell-type specific Bcl inhibitory activity. Compounds of this invention include compounds according to formula (I): Selected compounds in this class promote apoptosis in senescent cells, and are being developed for treating senescent-related conditions. Selected compounds in this class promote apoptosis in cancer cells, and can be developed as chemotherapeutic agents.Type: GrantFiled: June 19, 2019Date of Patent: July 21, 2020Assignee: Unity Biotechnology, Inc.Inventors: Anne-Marie Beausoleil, Ryan Hudson
-
Patent number: 10717723Abstract: The invention provides a method for producing a crystal of a uracil compound with high purity by a process which can be carried out in an industrial scale. Specifically, the invention provides a method for producing a crystal of a uracil compound, wherein the method comprises dissolving a composition comprising a uracil compound represented by formula (1) in organic solvents consisting of a C3-C6 alcohol solvent and an aromatic solvent to obtain a solution, and precipitating a crystal of said uracil compound from the solution.Type: GrantFiled: July 13, 2017Date of Patent: July 21, 2020Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Yuki Sato