Abstract: The invention features methods of treatment and diagnosis using NRG-2 polypeptides, nucleic acid molecules, and antibodies. The invention also provides novel NRG-2 polypeptides and nucleic acid molecules.

Abstract: Disclosed are tumor necrosis factor receptor 1B (TNFR-1B) signaling targets and TNFR-1B mutants and their uses for treatment of diseases and disorders.

Abstract: Peptides suitable for preparation of lung surfactants are described. Examples include one that include a first fragment comprising the amino acid sequence of XWLXRALIKRIQAZI (SEQ ID NO: 1) or a first amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and a second fragment comprising the amino acid sequence of RZLPQLVXRLVLRXS (SEQ ID NO: 2) or a second amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2, wherein X is any amino acid but at least one amino acid at the X positions is not cysteine, or Z is any amino acid but at least one amino acid at the Z positions is not methionine. Surfactants that contain such peptides, and related compositions, methods of preparing and using the compositions are also described.

Abstract: The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells wherein the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28, or CH44.

Abstract: There is disclosed compositions and methods relating to or derived from anti-DLL-4 antibodies. More specifically, there is disclosed fully human antibodies that bind DLL-4, DLL-4-binding fragments and derivatives of such antibodies, and DLL-4-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having DLL-4 related disorders or conditions, including various inflammatory disorders and various cancers.

Abstract: The present invention provides binding agents that contain n binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor-associated claudin molecule and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.

Abstract: The present inventors discovered that neural invasion is suppressed by inhibiting IL-6 in a model for neural invasion of pancreatic cancer, and completed the present invention. The present inventors also demonstrated that: an IL-6 receptor is expressed in cells of human pancreatic cancer cell lines; and IL-6 enhances the chemotactic and migratory activities and intracellular signaling of pancreatic cancer cells; and thus pancreatic cancer can be treated by inhibiting IL-6. Furthermore, the present inventors found that neural invasion of human pancreatic cancer can be suppressed, from the results of administering IL-6 inhibitors to neural invasion model mice.

Abstract: Described herein are compositions, methods, and systems for modulating Notch receptor activation. Aspects of the invention relate to synthetic proteins comprising at least a Notch NRR (Negative Regulatory Region)-binding scFV fused to a transmembrane domain. Another aspect of the invention relates to drug-dependent synthetic proteins. Constructs and engineered cells comprising the synthetic proteins are additionally described herein.

Abstract: A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different epitopes on HER2 receptor.

Abstract: The application discloses a combination of two monospecific TFPI antibodies, wherein one antibody is capable of specifically binding TFPI (1-181) and the other antibody is capable of specifically binding TFPI (182-276), as well as bispecific anti-TFPI antibodies derived from two such monospecific antibodies. Both the combination of the two monospecific antibodies and the bispecific antibody strongly enhance thrombin generation by neutralising full length TFPI?, even where the concentration of TFPI is abnormally elevated.

Abstract: The invention relates to means and methods that relate to binding molecules that bind human complement factor C2. Specific binding molecules are described with specific C2 activity inhibiting properties. Such binding molecules are useful in the treatment of symptoms of various human diseases among which there is inflammatory disease, neuro-inflammatory disease or ischemia-reperfusion (I/R) injury disease.

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract: Disclosed is an antibody which binds to a symmetrically dimethylated arginine analyte that can be used to detect a symmetrically dimethylated arginine analyte in a sample, such as in a homogeneous enzyme immunoassay method.

Abstract: A method is generally provided for attaching a polymer chain onto a surface of a nanoparticle, where the polymer chain comprises a cyclic arrangement of saccharides. The resulting grafted nanoparticle is also generally provided, along with its methods of use by exposing to a bacteria colony.

Abstract: A polydisperse inulin product has a factor L, defined as a ratio S/D, wherein: S equals the sum of the compounds GF2, F3, and F4 in the inulin product, expressed in wt. % on total carbohydrates; D equals [(Fi/Gi)+1], wherein Fi is the amount of inulin-related fructose in the inulin product, Gi is the amount of inulin-related glucose in the inulin product, whereby Fi and Gi are expressed in wt. % on total carbohydrates, wherein the value of L lies between 2.0 and 3.0 and wherein between 3 and 20 wt. % on total carbohydrates of the inulin product is: GFn compounds wherein n is 10 or greater, and/or Fm compounds wherein m is 11 or greater.

Abstract: This invention relates to a catalyst system including fluorided silica, alkylalumoxane activator and a bridged monocyclopentadienyl group 4 transition metal compound, where the fluorided support has not been calcined at a temperature of 400° C. or more, and is preferably, produced using a wet mix method, particularly an aqueous method.

Abstract: A procatalyst for polymerization of olefins, which procatalyst is based on a magnesium compound of the formula MgR?R? wherein R? is an alkoxide or aryloxide group and R? is an alkoxide or aryloxide group or halogen, an activator being a monoester and an internal donor represented by a compound according to formula A: as described herein. Also described is a polymerization catalyst system comprising the procatalyst, a co-catalyst and optionally an external electron donor; a process of making a polyolefin, by contacting an olefin with the catalyst system; a polyolefin, obtained by or obtainable by the process; and a polyolefin, having a molecular weight distribution of between 4 and 15, a molecular weight (Mw) of between 300,000 to 1,500,000 g/mol, a melting temperature of more than 150° C., a value for the xylene solubles of less than 4 wt. % and a shaped article therefrom.

Abstract: A polymer that is capable of affording a heat storage material superior in humidity permeability and shape retention after phase transition and that is superior in molding processability is provided. The polymer includes constitutional units (A) derived from ethylene, constitutional units (B) represented by a specified formula, and optionally includes constitutional units (C) represented by another specified formula. Where the total number of the units (A), the units (B), and the units (C) is 100%, the number of the units (A) accounts for 70% to 99%, the total number of the units (B) and the units (C) accounts for 1% by weight to 30% by weight. Where the total number of the units (B) and the units (C) is 100%, the number of the units (B) accounts for 1% to 100% and the number of the units (C) accounts for 0% to 99%.

Abstract: The present invention provides an olefin polymer in which LCB (long chain branch) is introduced into mLLDPE (metallocene linear low-density polyethylene) to control the storage modulus, whereby the olefin polymer has excellent bubble stability and processing load characteristics and exhibits excellent processability during preparation of a film, and further has excellent mechanical properties and transparency.

Abstract: The invention relates to an aqueous polymer dispersion having a viscosity of ?150 m Pas at 40% solids content and comprising polymer particles having a particle size D50 less than 85 nm. The polymer dispersion is obtainable by free radical emulsion copolymerisation of at least monomer (a) and monomer (b), where monomer (a) is at least one optionally substituted styrene and monomer (b) is at least one C1-C4-alkyl (meth)acrylate, in a reaction mixture comprising degraded starch which has an average molecular weight Mn<1000 g/mol. The invention relates also to the use of the polymer dispersion and method for preparing it.

Abstract: A copolymer having tetrafluoroethylene units, hexafluoropropylene units, and units independently represented by formula in a range from 0.001 to 2 mole percent, based on the total amount of the copolymer. In these units, a is 0 or 1, each b is independently from 1 to 4, c is 0 to 4, d is 0 or 1, and e is 1 to 6. In the —SO2X groups, X is independently —F, —NH2, —OH, or —OZ, wherein Z is independently a metallic cation or a quaternary ammonium cation. The copolymer has a melt flow index in a range from 20 grams per 10 minutes to 40 grams per 10 minutes. The copolymer can be extruded to make articles, such as insulated cables. A method of making the copolymer is also disclosed.

Abstract: Extruded films comprising ethylene vinyl alcohol copolymer (EVOH) with substantially no blow holes therein, are formed by using a pellet feed to the extruder wherein 90-100 wt. % of the pellets pass through an ASTM size 5 sieve and 0-10 wt. % of the pellets are finer than a number 10 mesh (ASTM Sieve size). Uniform feeding to and through the extruder with a lack of bridging of the EVOH pellet feed have been observed.

Abstract: Provided is a vinyl alcohol-based copolymer, obtained by saponifying a copolymer of vinyl acetate and a polyfunctional monomer, wherein the polyfunctional monomer contains two or more ethylenic double bonds in its molecule, the vinyl alcohol-based copolymer has a side chain containing an ethylenic double bond and a molar ratio (d) of the ethylenic double bond to a total of vinyl alcohol units and vinyl acetate units is from 0.05/100 to 2/100, and the vinyl alcohol-based copolymer is water soluble.

Abstract: A polymeric composition comprising (i) a plurality of monomers selected from (a) a carboxylic acryloyi monomer; (b) a sulfonic acryloyi monomer; (c) an amine acryloyi monomer; (d) a hydroxyl acryloyi monomer; (e) an alkyl acryloyi monomer; and (f) a polyalkylene hydroxyl acryloyi monomer; (ii) a divalent metallic crosslinking agent; and (c) a stabilizing agent is disclosed herein. Also provided are the use of said polymeric composition as a hydrogel coating material, a method of synthesizing the polymeric composition and the use of the hydrogel material.

Abstract: The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units derived from one or more than one second ethylenically unsaturated monomer as excipients in solid mixtures with poorly water-soluble substances for effective solubilization of the latter in aqueous media. Solid dosage forms comprising a solid mixture of such copolymer(s) and poorly water-soluble substance(s) are also within the scope of the invention.

Abstract: The latex polymer compositions of the present invention exhibit latent crosslinking properties. Latent crosslinking in the polymers takes advantage of the fast interaction between the anionic latex charge and the cationic charge associated with polyfunctional amine crosslinkers. Once the latex is coated onto a substrate, the volatile base evaporates and the groups react to form a crosslinked coating with improved wash-off properties.

Abstract: Provided are use of organosilane, in-reactor polyolefin alloy and preparation method thereof.

Abstract: The present invention relates to a method of preparing an ABS-based resin composition and a method of manufacturing an ABS-based injection-molded article including the same. More particularly, the present invention provides a method of preparing an ABS-based resin composition using a multimeric acid of unsaturated fatty acid or a metal salt thereof, as an emulsifier, in a diene-based rubber latex polymerization step and an ABS-based graft polymerization step. In accordance with the present invention, when an ABS-based resin composition is prepared using a multimeric acid of unsaturated fatty acid or a metal salt thereof as an emulsifier, stability of polymerization is secured and surface characteristics, such as surface gloss or sharpness, of an ABS-based injection-molded article are improved.

Abstract: A block copolymer, in particular for use as a dispersant for mineral binder compositions, including at least one first block A and at least one second block B, wherein the first block A has a monomer unit M1 and the second block B has a monomer unit M2. To this end a proportion of monomer units M2 which is in any case present in the first block A is less than 25 mol %, in particular less than or equal to 10 mol %, based on all the monomer units M1 in the first block A and a proportion of monomer units M1 which is in any case present in the second block B is less than 25 mol %, in particular less than or equal to 10 mol %, based on all the monomer units M2 in the second block B.

Abstract: The present invention provides a silicon-containing compound shown by the following formula (1): wherein R1, R2, R3, R4, R5, and R6 each independently represent a linear, branched, or cyclic alkyl group having 1 to 6 carbon atoms, a phenyl group, a 3,3,3-trifluoropropyl group, or a group shown by —(OSiR7R8)n—OSiR9R10R11; R7, R8, R9, R10, and R11 have the same meanings as R1 to R6; X represents a linear or branched alkylene group having 3 to 7 carbon atoms optionally having an ether group; and “n” is an integer in the range of 0 to 100. This provides a stretchable film that has excellent stretchability and strength, with the film surface having excellent repellency, and a method for forming the same; as well as a urethane resin used for the stretchable film; and a silicon-containing compound to be a material of the urethane resin.

Abstract: The invention relates to a process for producing polyisocyanurate plastics, comprising the following steps: (a) providing a polyisocyanate composition A) which contains oligomeric polyisocyanates and is low in monomeric diisocyanates, where the isocyanurate structure content in the polyisocyanate composition A) is at least 50 mol %, based on the sum total of the oligomeric structures from the group consisting of uretdione, isocyanurate, allophanate, biuret, iminooxadiazinedione and oxadiazinetrione structure that are present in the polyisocyanate composition A); (b) catalytically trimerizing the polyisocyanate composition A), where (i) the catalytic trimerization is conducted at ambient temperatures of at least 80° C.; (ii) the catalytic trimerization is conducted within less than 12 hours at least up to a degree of conversion at which only still not more than 20% of the isocyanate groups originally present in the polyisocyanate composition A) are present.

Abstract: A packaging material is provided. The packaging material includes (a) epoxy silsesquioxane, (b) epoxy resin, and (c) siloxane-imide-containing benzoxazine compound. (a) Epoxy silsesquioxane and (b) epoxy resin have a weight ratio of 0.3:1 to 10:1. The total weight of (a) epoxy silsesquioxane and (b) epoxy resin and the weight of (c) siloxane-imide-containing benzoxazine compound have a ratio of 100:20 to 100:150.

Abstract: Disclosed are an epoxy resin composition and an article made therefrom, the epoxy resin composition comprising an epoxy resin and a co-hardener, wherein: relative to the epoxy resin having a total equivalent of epoxy group of 1, the co-hardener comprises: (A) an acid anhydride having a total equivalent of acid anhydride group of 0.044-0.183; (B) a polyester having a total equivalent of ester group of 0.120-0.550; (C) a first phenolic resin having an equivalent of hydroxyl group of 0.092-0.550; and (D) a second phenolic resin having an equivalent of hydroxyl group of 0.143-0.592; and a sum of equivalent of functional groups of the co-hardener is 0.84-1.11.

Abstract: Disclosed herein is an epoxy resin compositions comprising an epoxy component and a curing agent component, wherein the curing agent component is at least an aminoalkylimidazole curing agent, and wherein the epoxy component and the curing agent component react together at a temperature of about 100° C. to about 130° C. to form a substantially cured reaction product in about 10 minutes or less. Further disclosed are composite products formed from such epoxy resin compositions.

Abstract: The invention provides a production method of a polymer compound having a constitutional unit represented by the formula (3-1) and a constitutional unit represented by the formula (3-2), which contains a step of reacting a compound represented by the formula (1) and a compound represented by the formula (2) in the presence of a transition metal complex, a base and an organic solvent having a peroxide amount of 15 ppm by weight or less: wherein Ar1 and Ar2 represent a divalent aromatic hydrocarbon group, a divalent heteroaromatic group, a group represented by the formula (4) or the like; X1 represents a bromine atom or the like; X2 represents —B(OH)2, a borane residue, a borate ester residue or the like; wherein Ar represents a divalent aromatic hydrocarbon group, a divalent heteroaromatic group or the like, Ar? represents an aryl group or a monovalent heteroaromatic group, m represents an integer of 0-2.

Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.

Abstract: A polyester based copolymer resin which can be used a heat shrinkable film is disclosed. The polyester based copolymer resin includes a dicarboxylic acid-derived residue including a residue derived from an aromatic dicarboxylic acid, and a diol-derived residue including a residue derived from 4-(hydroxymethyl)cyclohexylmethyl 4?-(hydroxymethyl)cyclohexane carboxylate and a residue derived from 4,4-(oxybis(methylene)bis) cyclohexane methanol. The heat shrinkable film including polyester based copolymer resin has a shrinkage initiation temperature of 60° C. or less, the maximum heat shrinkage rate at 60° C. of 4% or more, and the maximum heat shrinkage rate at 90° C. of 80% or more.

Abstract: The present disclosure relates to copolymers and methods for copolymer preparation. Disclosed herein are high molecular weight copolymers of lactones and epoxides and methods for their synthesis.

Abstract: Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone) diol in the presence of an alkali metal salt. The resulting photocrosslinkable biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable an in-situ hardening scaffolds for application in skeletal reconstruction.

Abstract: The purpose of the present invention is to provide a polycarbonate resin which has high fluidity and with which mold fouling such as mold deposits, etc., can be reduced. The polycarbonate resin according to the present invention has a terminal structure represented by general formula (1), and a viscosity-average molecular weight of 10,000-18,000, wherein the contained amount of low-molecular-weight carbonate compounds having a molecular weight of 1,000 or less contained in the polycarbonate resin is less than 1 mass %.

Abstract: A polymer composition [composition (C)] comprising: (a) a polyarylene ether ketone (PAEK-1) comprising recurring units deriving from the incorporation of 1,4:3,6-dianhydrohexitols; (b) a poly(biphenyl ether) sulfone (PPSU-1) comprising repeating units of formula (I) and/or (c) a polyetherimide (PEI-1) comprising repeating units of formula (II) wherein Ar* and Ar*? are as defined in the specification are herein disclosed. (PAEK-1) and (PPSU-1) and/or (PEI-1) are completely miscible and give rise to compositions that are transparent and possess high strength and stiffness and that are suitable for the manufacture of a variety of shaped articles.

Abstract: The present invention relates to a polyamide molding compound comprising the following components or consisting of these components: (A) 40 to 95 wt % of a specific polyamide mixture consisting of the polyamides (A1) and (A2); (B) 5 to 50 wt % of at least one glass filler having a refractive index in the range from 1.540 to 1.600; (C) 0 to 10 wt % of at least one additive; wherein the weight proportions of the components (A) to (C) add up to 100% wt %; wherein the at least one transparent polyamide (A2) has a transparency of at least 90% and a haze of at most 3%. The present invention additionally relates to molded bodies composed of this polyamide molding compound.

Abstract: A process to prepare polycarbamate comprising adding urea to a polyol in the presence of at least one catalyst selected from the group consisting of compounds having the following formula MmZn; wherein M is a divalent metal, and Z is an anionic functionality or a functionality capable of forming a covalent bond with M and wherein n times a valence number of Z equals X and m times two equals Y wherein the absolute value of X equals the absolute value of Y is provided. Also provided are a polycarbamate produced according to the process and a coating composition comprising the polycarbamate.

Abstract: It is possible to obtain a thin film that can form a minute pattern and that has a high index of refraction by using a polymer containing a triazine ring and containing a repeating unit structure represented for example by formula (22) or (26).

Abstract: The present disclosure relates to a polyimide-based block copolymer film. The polyimide-based block copolymer film according to the present disclosure exhibits excellent an ultraviolet shielding property to be suitably used for substrates for displays, protective films for displays, touch panels, and the like.

Abstract: Condensation of fluoro-substituted and silyl-substituted monomers provides polymers suitable for use, e.g., as engineering polymers. A monomer composition is condensed in the presence of a bifluoride or poly(hydrogen fluoride) fluoride salt. The monomer composition contains a compound of formula F-X-F and a compound of formula (R1)3Si—Z—Si(R1)3, and forms an alternating X-Z polymer chain and a silyl fluoride byproduct. X has the formula -A(-R2-A)n-; each A is SO2, C(?O), or Het; R2 is an organic moiety; n is 0 or 1; Het is an aromatic nitrogen heterocycle; Z has the formula -L-R3-L-; each L is O, S, or N(R4); and each R3 is an organic moiety, and R4 comprises H or an organic moiety.

Abstract: A two part moisture curing composition, exhibiting low thermal conductivity, has a part A) and a part B). Part A) comprises either: 1) a siloxane polymer (I) having at least two terminal hydroxyl or hydrolysable groups and a viscosity of from 20,000 to 40,000 mPa·s at 25° C.; or 2) a polymer mixture (II) of polymer (i) a siloxane polymer having at least two terminal hydroxyl or hydrolysable groups and a viscosity?25,000 mPa·s at 25° C., and polymer (ii) a siloxane polymer having at least two terminal hydroxyl or hydrolysable groups and a viscosity of between 1,000 and 20,000 mPa·s at 25° C. Part A) further comprises a reinforcing filler and a low-density filler, the total filler content being between 30 and 45% in volume of the total composition. Part B) comprises a moisture curing agent formulation comprising a tin based catalyst and one or more crosslinkers.

Abstract: Compositions of matter that have adhesion properties. The presence of a large number of silanols on the molecules described herein creates a solubility or dispersability of these molecules in aqueous solutions that is not obtainable from random hydrolysis of the precursor silanes.

Abstract: The present application relates to silicone compounds, compositions, packaged products and displays comprising such silicone compounds, and processes for making and using such compositions, packaged products and displays comprising such compositions. Such compositions have improved deposition and retention properties that may impart improved benefit characteristics to a composition and/or situs yet which changes its hydrophilicity/charge and/or demonstrates cleavage of the functionalized silicone's functionalization when desired.

Abstract: A method of producing a polymer aerogel can include dissolving gel precursors consisting of radical polymerizable monomers and crosslinkers, radical initiators, and a chain transfer agent (CTA) in a reaction solvent, wherein the monomers and cross-linkers produce stiff homopolymers; placing the gel precursors into a substrate; polymerizing the gel on the substrate; optionally removing the wet gel from the mold; optionally performing at least one solvent exchange on the gel; and removing the reaction solvent.