Patents Issued in July 21, 2020
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Patent number: 10717926Abstract: An atom, molecule, atomic layer molecular layer is adhered to a carbon nanotube surface, or the surface is doped with the atom, molecule, atomic layer, or molecular layer, to form a deep localized level so that an exciton is localized. Alternatively, an atom, molecule, inorganic or organic substance of an atomic or molecular layer, a metal, a semiconductor, or an insulator is absorbed to, deposited on, or encapsulated in the carbon tube inside surface to make permittivity of the portion undergoing the absorption, deposition, or encapsulation higher than that of a clean portion free of the absorption, deposition, or encapsulation so that binding energy of the exciton in the clean portion is high, or reduce a band gap of the portion undergoing the absorption, deposition, or encapsulation so that the exciton is confined and localized in the clean portion or the position undergoing the absorption, deposition, or encapsulation.Type: GrantFiled: June 4, 2018Date of Patent: July 21, 2020Assignee: KEIO UNIVERSITYInventor: Hideyuki Maki
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Patent number: 10717927Abstract: An indium-containing quantum dot including a compound represented by Chemical Formula 1: In1-xMxA ??Chemical Formula 1 wherein, in Chemical Formula 1, M is aluminum, gallium, yttrium, or scandium, A is nitrogen, phosphorous, arsenic, antimony, bismuth, or a combination thereof, and X is greater than or equal to 0 and less than 1, wherein the indium-containing quantum dot includes fluorine and oxygen to bonded to a surface of the indium-containing quantum dot, wherein an amount of the fluorine is greater than or equal to about 10 atomic percent based on a total number of indium atoms in the indium-containing quantum dot as determined by Rutherford backscattering analysis, and wherein an amount of the oxygen is about 5 atomic percent to about 50 atomic percent based on the total number of indium atoms included in the quantum dot as determined by Rutherford backscattering analysis.Type: GrantFiled: July 14, 2016Date of Patent: July 21, 2020Assignees: SAMSUNG ELECTRONICS CO., LTD., UNIVERSITY OF CALIFORNIA, BERKELEYInventors: Tae Gon Kim, Yehonadav Bekenstein, Eun Joo Jang, Paul Alivisatos
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Patent number: 10717928Abstract: A method for producing a mixed calcium and magnesium compound comprising the slaking of quicklime with a magnesium hydroxide suspension, forming solid particles, said slaking by non-wet means forming said solid particles comprising a calcium phase and a magnesium phase intimately bonded to each other and of homogeneous volume distribution, and a mixed compound comprising a calcium phase and a magnesium phase.Type: GrantFiled: July 12, 2013Date of Patent: July 21, 2020Assignee: S.A. Lhoist Recherche et DeveloppementInventors: Marion Lorgouilloux, Alain Laudet
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Patent number: 10717929Abstract: The present invention relates to the use of ionic liquids as flame retardants. The compounds of the invention may be used as flame retardants in various materials without causing damage to the environment and or health of humans or animals. Ionic liquid flame retardants maybe applied alone or in combination with traditional flame retardants. Ionic liquid flame retardants can be applied to finish textile, plastic, leather, paper, rubber or as wild fire flame retardants.Type: GrantFiled: November 16, 2010Date of Patent: July 21, 2020Assignee: IONIC FLAME RETARDANT INC.Inventor: Yanjie Xu
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Patent number: 10717930Abstract: A flame retardant lysine-based derivative, a process for forming a flame retardant lysine-based derivative, and an article of manufacture comprising a flame retardant lysine-based derivative are disclosed. The flame retardant lysine-derived molecule can be synthesized from a bio-based source, and can have at least one phosphoryl or phosphonyl moiety. A flame retardant proline-based derivative, a process for forming a flame retardant proline-based derivative, and an article of manufacture comprising a flame retardant proline-based derivative are also disclosed. The flame retardant proline-derived molecule can be synthesized from a bio-based source and can have at least one phosphoryl or phosphonyl moiety.Type: GrantFiled: March 20, 2019Date of Patent: July 21, 2020Assignee: International Business Machines CorporationInventors: Scott B. King, Brandon M. Kobilka, Joseph Kuczynski, Jason T. Wertz
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Patent number: 10717931Abstract: Embodiments described herein are directed to oligomeric phosphonates and polyphosphonates that have non-reactive end groups, methods for making such oligomeric phosphonates and polyphosphonates, and compositions containing such oligomeric phosphonates and polyphosphonates. The oligomeric phosphonates and polyphosphonates of such embodiments may be incorporated into engineering polymeric into which they are mixed to make polymer compositions having good flame retardancy and mechanical properties.Type: GrantFiled: January 5, 2018Date of Patent: July 21, 2020Assignee: FRX POLYMERS, INC.Inventors: Jan-Pleun Lens, Lawino Kagumba
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Patent number: 10717932Abstract: An apparatus for raising and lowering a cutting tool within a decoking drum, a decoking system and a method of raising and lowering a decoking system cutting tool. Instead of using metallic ropes, chains, or a self-propelled gear-based approach, non-metallic belts are secured at respective ends to a crosshead and one or more counterweights to enable vertical movement of the crosshead that in turn permits vertical movement of the cutting tool throughout the height of the drum. A motorized pulley system controls the movement of the belt, and preferably avoids having the motor be carried by the crosshead. The belts on each pulley are preferably arranged as cooperative sets so that within each set, both primary load belts and secondary load belts are present.Type: GrantFiled: September 30, 2015Date of Patent: July 21, 2020Assignee: Flowserve Management CompanyInventors: Daniel O. Arzuaga, Hrishikesh Raghunath Gadre
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Patent number: 10717933Abstract: This disclosure describes a non-vented, novel, evacuated, continuous flow infrared gasification apparatus and a method for the controlled and adaptive thermophysical transformation of non-aqueous granular organic materials to a gaseous state and specific inorganic materials to a liquid and/or gaseous state.Type: GrantFiled: August 8, 2017Date of Patent: July 21, 2020Inventor: James William Masten, Jr.
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Patent number: 10717934Abstract: A process for treating waste comprising Mixed Plastic Waste is disclosed. The process includes feeding the waste to a pyrolysis reactor, pyrolysing the waste in the pyrolysis reactor to produce a fuel and using the fuel to run a generator to produce electricity.Type: GrantFiled: September 7, 2018Date of Patent: July 21, 2020Assignee: Recycling Technologies Ltd.Inventor: Adrian Edward Griffiths
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Patent number: 10717935Abstract: The invention provides a method for enriching diluents with butane so as not to violate pre-defined limits for liquid hydrocarbon fuels with respect to density, volatility and low density hydrocarbon content.Type: GrantFiled: March 2, 2017Date of Patent: July 21, 2020Assignee: Texon LPInventors: Larry D. Mattingly, Ronnie D. Andrews
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Patent number: 10717936Abstract: A process for processing mixed plastics comprising simultaneous pyrolysis and dechlorination of the mixed plastics, the process comprising contacting the mixed plastics with a zeolitic catalyst in a pyrolysis unit to produce a hydrocarbon product comprising a gas phase and a liquid phase; and separating the hydrocarbon product into a hydrocarbon gas stream and a hydrocarbon liquid stream, wherein the hydrocarbon gas stream comprises at least a portion of the gas phase of the hydrocarbon product, wherein the hydrocarbon liquid stream comprises at least a portion of the liquid phase of the hydrocarbon product, wherein the hydrocarbon liquid stream comprises one or more chloride compounds in an amount of less than about 100 ppmw chloride, based on the total weight of the hydrocarbon liquid stream, and wherein the hydrocarbon liquid stream is characterized by a viscosity of less than about 400 cP at a temperature of 300° C.Type: GrantFiled: July 17, 2017Date of Patent: July 21, 2020Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Alexander Stanislaus, Ravichander Narayanaswamy, Krishna Kumar Ramamurthy, Santosh Ganji, Abrar A. Hakeem, Ashim Kumar Ghosh, Girish Koripelly, Mohammad Javeed
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Patent number: 10717937Abstract: Process and plant for recovering LPG in a refinery process combining the use of sponge absorber, deethanizer and debutanizer. The process and plant enable high LPG recovery and removal of hydrogen sulphide in the LPG product to low levels.Type: GrantFiled: September 21, 2016Date of Patent: July 21, 2020Assignee: HALDOR TOPSØE A/SInventor: Nghia Pham Phu
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Patent number: 10717938Abstract: In a method of hydroprocessing, hydrogen gas for the hydroprocessing reaction is combined with a liquid feed composition comprising a feedstock to be treated and a diluent to form a feed stream, at least a portion of the hydrogen gas being dissolved in the liquid feed composition of the feed stream, with non-dissolved hydrogen gas being present in the feed stream in an amount of from 1 to 70 SCF/bbl of the liquid feed composition. The feed stream is contacted with a hydroprocessing catalyst, within a reactor while maintaining a liquid mass flux within the reactor of at least 5000 lb/hr·ft2 to form a hydroprocessed product.Type: GrantFiled: April 12, 2019Date of Patent: July 21, 2020Assignee: Duke Technologies, LLCInventors: Michael D. Ackerson, Michael Steven Byars
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Patent number: 10717939Abstract: Disclosed is a desulfurization catalyst for hydrocarbon oils, comprising a support and at least one metal promoter selected from the group consisting of cobalt, nickel, iron and manganese, the support comprising at least one metal oxide selected from the group consisting of oxides of Group IIB, Group VB and Group VIB metals and a refractory inorganic oxide, wherein the support further comprises at least about 5% by weight of vanadium carbide, based on the total weight of the desulfurization catalyst for hydrocarbon oils. The desulfurization catalyst for hydrocarbon oils shows a good stability, a high desulfurization activity, an excellent abrasion resistance, and a long service life. Also disclosed is a process for preparing the desulfurization catalyst for hydrocarbon oils, and use of the catalyst in the desulfurization of sulfur-containing hydrocarbon oils.Type: GrantFiled: October 20, 2017Date of Patent: July 21, 2020Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, RESEARCH INSTITUTE OF PETROLEUM PROCESSING, SINOPECInventors: Wei Lin, Ye Song, Huiping Tian, Lei Wang, Jun Liu
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Patent number: 10717940Abstract: The present disclosure relates to a catalyst for slurry phase hydrocracking of refinery residue and a process for its preparation. The present disclosure provides a very simple method for exfoliation of metal sulphide, and a process of that provides effective slurry phase hydrocracking of refinery residue with a high yield.Type: GrantFiled: June 17, 2016Date of Patent: July 21, 2020Assignee: Hindustan Petroleum Corporation LimitedInventors: Nettem Venkateswarlu Choudary, Kanuparthy Naga Raja, Raman Ravishankar, Bipul Sarkar, Valavarasu Gnanesekaran, Peddy Venkata Chalapathi Rao, Sriganesh Gandham
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Patent number: 10717941Abstract: Process scheme configurations are disclosed that enable conversion of crude oil feeds with several processing units in an integrated manner into petrochemicals. The designs utilize minimum capital expenditures to prepare suitable feedstocks for the steam cracker complex. The integrated process for converting crude oil to petrochemical products including olefins and aromatics, and fuel products, includes mixed feed steam cracking and fluid catalytic cracking. Feeds to the mixed feed steam cracker include light products and naphtha from hydroprocessing zones within the battery limits, recycle streams from the C3 and C4 olefins recovery steps, and raffinate from a pyrolysis gasoline and FCC naphtha aromatics extraction zone within the battery limits.Type: GrantFiled: November 17, 2017Date of Patent: July 21, 2020Assignee: Saudi Arabian Oil CompanyInventors: Mohammed Saeed Al-Ghamdi, Bader BaHammam, Naif Al Osaimi, Sami Barnawi
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Patent number: 10717942Abstract: A lubricant base oil composed of an ester. The ester includes a component (A) derived from trimethylolpropane in a molar percentage Amol % of 25 to 42 mol %; components (B) derived from monovalent straight-chain saturated fatty acids each having a carbon number of 8 to 12 in a molar percentage Bmol % of 33 to 55 mol %: and a component (C) derived from adipic acid in a molar ratio Cmol % of 12 to 34 mol %. The components (B) include lauric acid in a molar percentage of 5 to 50 mol %, and (BCOOH+CCOOH)/AOH is 0.90 to 1.02. AOH represents a hydroxyl equivalent of the component (A), BCOOH represents a carboxyl group equivalent of the components (B); and CCOOH represents a carboxyl group equivalent of the component (C).Type: GrantFiled: June 7, 2017Date of Patent: July 21, 2020Assignee: NOF CORPORATIONInventors: Hideki Kawamoto, Shunsuke Monjiyama
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Patent number: 10717943Abstract: An industrial lubricant composition including an oil base selected from the group consisting of vegetable oil, Group I, Group II, Group III, Group IV, Group V and combinations thereof and a phosphorus-based non-chlorine additive. The industrial lubricant also includes at least one intercalation compound of a metal chalcogenide, a carbon containing compound and a boron containing compound, wherein the intercalation compound may have a geometry that is a platelet shaped geometry, a spherical shaped geometry, a multi-layered fullerene-like geometry, a tubular-like geometry or a combination thereof.Type: GrantFiled: July 26, 2019Date of Patent: July 21, 2020Assignee: NANOTECH INDUSTRIAL SOLUTIONS, INC.Inventors: Roger G. Soto-Castillo, Girija S. Chaubey, George Diloyan
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Patent number: 10717944Abstract: A lubricating oil composition for automotive transmissions is disclosed. It offers an automotive transmission (especially a fuel-saving type) which satisfies all requirements as regards the properties of resistance to churning, maintenance of the oil film and low-temperature viscosity. It comprises a GTL low viscosity base oil and a Group 1 high viscosity base oil.Type: GrantFiled: September 28, 2015Date of Patent: July 21, 2020Assignee: SHELL OIL COMPANYInventors: Noriaki Shinoda, Ryuji Maruyama, Katsuji Okami
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Patent number: 10717945Abstract: The present invention relates to an odoriferous mixture with improved intensity and longevity, capable of masking bad odours, said mixture comprising at least dihydro-5-pentyl-2(3H)-furanone at a percentage between 20 and 80% by weight and 2,4-dimethyl-4-phenyltetrahydrofuran at a percentage between 20 and 80% by weight, the percentages by weight being relative to the total weight of said mixture. The invention also relates to the cosmetic, detergent or scented products comprising said mixture.Type: GrantFiled: June 14, 2017Date of Patent: July 21, 2020Assignee: EXPRESSIONS PARFUMEESInventors: Christophe Marin, Stéphane Coez, Jennifer Buzzi, Christophe Deroo
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Patent number: 10717946Abstract: Methods for adjusting the solubility of a botanical oil in water, along with the resulting modified botanical oil and related products (e.g., treatment compositions, wipes, absorbent articles, etc.) are provided. In one embodiment, the method includes reacting the botanical oil to form a reactive product (e.g., having a hydroxyl group); and attaching a hydrophilic end group (e.g., a carboxylic acid, a carboxylic acid salt, a sugar, etc.) on the reactive product to form a modified botanical oil. The modified botanical oil generally, in most embodiments, has a greater solubility in water than the botanical oil (e.g., a solubility in water of about 10 grams per 100 grams of water or greater, such as completely soluble in water). The botanical oil includes, in one particular embodiment, an essential oil, such as those essential oil that include at least one terpene compound.Type: GrantFiled: December 27, 2012Date of Patent: July 21, 2020Assignee: Kimberly-Clark Worldside, Inc.Inventors: David William Koenig, Mary Kay Foegen, Corey Thomas Cunningham, Aimin He, Yang Huang
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Patent number: 10717947Abstract: The present invention provides a solid composition comprising (a) a quaternary ammonium compound and (b) between 9 wt % and 77 wt % of a polysaccharide based on the total weight of the solid composition. The solid composition showed excellent stability. The present invention also provides a process for preparing the solid composition and a liquid composition comprising said solid composition, and methods for conditioning a fabric by using the solid composition and the liquid composition as well.Type: GrantFiled: December 22, 2015Date of Patent: July 21, 2020Assignee: Rhodia OperationsInventors: Hai Zhou Zhang, Nikolay Christov, Da Wei Jin, Lin He
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Patent number: 10717948Abstract: A method of laundering a fabric comprising the steps of; (i) contacting the fabric with a cutinase, (ii) contacting the fabric from step (i) with a soil; (iii) contacting the fabric from step (ii) with a laundry detergent composition, wherein the laundry detergent composition comprises a hueing agent.Type: GrantFiled: February 19, 2014Date of Patent: July 21, 2020Assignee: The Procter & Gamble CompanyInventors: Neil Joseph Lant, Linsey Sarah Bennie, Steven George Patterson, Lindsay Suzanne Bewick
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Patent number: 10717949Abstract: Provided is an alkaline protease mutant with improved stability to a chelating agent. An alkaline protease mutant, in which an amino acid residue at a position corresponding to position 294 of the amino acid sequence as shown in SEQ ID NO: 2 is substituted in the amino acid sequence as shown in SEQ ID NO: 2, or an amino acid sequence having an identity of at least 95% thereto.Type: GrantFiled: June 7, 2017Date of Patent: July 21, 2020Assignee: Kao CorporationInventors: Kozo Yamada, Tsuyoshi Sato
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Patent number: 10717950Abstract: A laundry care composition including (a) at least one laundry care ingredient and (b) a leuco composition including at least one leuco compound. The leuco compound including a leuco moiety and a polyalkyleneoxy moiety covalently bound to the leuco moiety. The polyalkyleneoxy moiety includes at least one ethylene oxide group and at least one propylene oxide group. A method of treating a textile includes the steps of (a) providing such a laundry care composition; (b) adding the laundry care composition to a liquid medium; (c) placing textile articles in the liquid medium; (d) optionally, rinsing the textile; and (e) drying the textile articles.Type: GrantFiled: October 11, 2018Date of Patent: July 21, 2020Assignee: The Procter & Gamble CompanyInventors: Gregory Scot Miracle, Daniel Dale Ditullio, Jr., Haihu Qin, Sanjeev Kumar Dey, Wesley A. Freund, Randy D. Petrea
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Patent number: 10717951Abstract: A laundry care composition including (a) at least one laundry care ingredient and (b) a leuco compound including an antioxidant moiety covalently bonded to a leuco moiety.Type: GrantFiled: October 11, 2018Date of Patent: July 21, 2020Assignee: The Procter & Gamble CompanyInventors: Gregory Scot Miracle, Sanjeev Kumar Dey, Haihu Qin, Dominick Joseph Valenti
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Patent number: 10717952Abstract: A process for producing a formulation that is solid at up to a temperature of at least 60° C., wherein (a) at least one nonionic surfactant of the general formula (I), R1—CH(OH)—CH2-(AO)x—R2 (I) (wherein: R1 is C4-C20-alkyl, R2 is C8-C20-alkyl, AO are each independently C2-C4-alkylene, and x is in a range from 5 to 100), is mixed in a molten state with (b) at least one second substance selected from polyethylene glycol and nonionic surfactants different from surfactants of general formula (I), confectioned, mixed and ground in the solid state with (c) silica or silicate and (d) at least one auxiliary selected from alkali metal citrate, alkali metal carbonate or at least one chelating agent selected from compounds of the general formula (II), R3—CH(COOM1)-N(CH2COOM1)2 (II) (wherein: R3 is C1-C4-alkyl, phenyl, benzyl, CH2OH and CH2CH2COOM1, and M1 is an alkali metal or a combination of at least two alkali metals). Furthermore granules and their use.Type: GrantFiled: October 18, 2016Date of Patent: July 21, 2020Assignee: BASF SEInventors: Rainer Eskuchen, Robert Schuetz
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Patent number: 10717953Abstract: A single dose pack and methods for producing and using the same are provided. In one embodiment, a single dose pack includes a container, wherein the container comprises a water-soluble film, and a wash composition encapsulated within the container. The wash composition includes a detergent surfactant, water present in an amount of from about 8 to about 40 weight percent, based on the total weight of the wash composition, and a polyethylene glycol (PEG) blend. The PEG blend includes at least one relatively higher molecular weight (MW) PEG having an average MW of about 1500 Daltons or greater in combination with at least one relatively lower MW PEG having an average MW of about 400 Daltons or less and/or at least one mid-MW PEG having an average MW of between about 400 and about 1500 Daltons.Type: GrantFiled: March 1, 2018Date of Patent: July 21, 2020Assignee: Henkel IP & Holding GmbHInventors: Daniel Thomas Piorkowski, Casey Elphege Camire, David S. Stott, II
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Patent number: 10717954Abstract: The present invention describes a detergent composition in the form of a flexible sheet, which in turn is soluble in water, and the water-soluble detergent sheet. Said detergent composition in the form of a flexible sheet comprises a unique mixture of components, including: a water-soluble polymeric component, an anionic surfactant, a non-ionic surfactant, water and other components. Once mixed in the appropriate proportions, the components produce a flexible sheet with detergent characteristics that can be incorporated directly into a clothes-washing recipient, said recipient ranging from a simple bowl to an advanced automatic washing machine. Once the detergent sheet comes into contact with water inside the washing recipient, the sheet dissolves and releases the active ingredients and complementary ingredients contained therein.Type: GrantFiled: September 5, 2017Date of Patent: July 21, 2020Assignee: SOLUBAG SpAInventor: Roberto Astete Boettcher
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Patent number: 10717955Abstract: The disclosure provides a method for selectively removing sulfites, for example bisulfite anionic species, from a beverage comprising free sulfite by providing an effective amount of a non-ionic, solid phase material and contacting the beverage with the solid phase material thereby sequestering the free sulfite on the non-ionic, solid phase material and providing a beverage having a reduced amount of free sulfite that otherwise maintains the general chemical composition with which it started. The disclosure further provides a device for selectively removing sulfite from a beverage comprising a container for receiving a beverage comprising free sulfite, said container enclosing a non-ionic, solid phase material capable of sequestering free sulfite, and a modular apparatus comprising a sulfite capture module and optionally a sediment filter module or an aeration module. Optionally, the non-ionic solid phase material is food-safe.Type: GrantFiled: October 2, 2014Date of Patent: July 21, 2020Inventor: James Richard Kornacki
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Patent number: 10717956Abstract: There is disclosed a system and method for processing wine and/or a containing barrel, while keeping a volume of most of the wine in the barrel. The disclosed system and method can provide reduced mixing of different layers of wine in the barrel. An optional scrubbing mechanism cleans an interior surface of the barrel from encrusted matter, and an optional UV sterilization light source sanitizes an interior surface of the barrel that is alongside a cavity in the barrel empty of wine. In some embodiments a pumping and filtering system preserves non-mixing flow of wine in the barrel while effectively filtering wine optionally without the use of a filter cartridge or other interposing medium.Type: GrantFiled: August 18, 2016Date of Patent: July 21, 2020Assignee: Ariel-University Research and Development Company Ltd.Inventor: Elyashiv Drori
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Patent number: 10717957Abstract: A method of ranking embryos to indicate their development potential.Type: GrantFiled: October 2, 2015Date of Patent: July 21, 2020Assignee: UNISENSE FERTILITECH A/SInventors: Bjorn Molt Petersen, Mai Faurschou, Mikkel Boel
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Patent number: 10717958Abstract: A method for improving productivity in microbial fermentations and mammalian cell culture bioreactors.Type: GrantFiled: May 1, 2019Date of Patent: July 21, 2020Assignee: CMC BIOLOGICS A/SInventor: Mads Laustsen
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Patent number: 10717959Abstract: The present disclosure relates to methods for control of cell growth rates where cell growth is measured in situ. The methods are applicable to bacterial cells, mammalian cells, non-mammalian eukaryotic cells, plant cells, yeast cells, fungi, and archea.Type: GrantFiled: February 3, 2020Date of Patent: July 21, 2020Assignee: Inscripta, Inc.Inventors: Phillip Belgrader, Don Masquelier
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Patent number: 10717960Abstract: This patent document relates to the field of biotechnological apparatuses. It relates particularly to a biotechnological apparatus comprising a bioreactor, an exhaust gas temperature control device and a method for treating an exhaust gas stream. This patent document further relates to a connection device for a sterile single-use fluid conduit of a single-use bioreactor and to a method for treating a fluid stream. The reusable connection device comprises a receptacle in which a portion of the fluid conduit can be detachably arranged, and a coupling member connecting the connection device to a temperature control device, the receptacle having a contact surface which is arranged such that the contact surface abuts a fluid conduit arranged in the receptacle, and wherein a portion of a fluid conduit can be introduced into the receptacle in a direction running substantially orthogonally to a longitudinal axis of the connection device.Type: GrantFiled: October 10, 2012Date of Patent: July 21, 2020Assignee: DASGIP INFORMATION AND TECHNOLOGY GMBHInventors: Matthias Arnold, Heinz Gerhard Köhn, Nico Gülzow, Sven Eikelmann, Guido Ertel, Sebastian Selzer
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Patent number: 10717961Abstract: A cell culture system having a cell culture vessel, a composition controlling fluid storage vessel, a culture fluid composition controlling means having an inlet and an outlet for a cell culture fluid, an inlet-connected fluid feeding circuit from the cell culture vessel to the inlet of the culture fluid composition controlling means, an outlet-connected fluid feeding circuit from the cell culture vessel to the outlet of the culture fluid composition controlling means, a means which perfuses the cell culture fluid from the inlet-connected fluid feeding circuit to the outlet-connected fluid feeding circuit through the culture fluid composition controlling means, and a means which controls the amount of fluid in the cell culture vessel, in which compositions of the cell culture fluid in the cell culture vessel and compositions of the composition controlling fluid in the composition controlling fluid storage vessel can be controlled in a continuous manner.Type: GrantFiled: April 24, 2013Date of Patent: July 21, 2020Assignees: ASAHI KASEI KABUSHIKI KAISHA, TOKYO WOMEN'S MEDICAL UNIVERSITYInventors: Ushio Iwamoto, Michi Sato, Kanako Konishi, Katsuhisa Matsuura, Tatsuya Shimizu, Teruo Okano
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Patent number: 10717962Abstract: Provided is a method for non-invasively and quantitatively determining multilayerization and differentiation when culturing a cell sheet. Provided is a method for determining a cell state by imaging a cell sheet by using an optical instrument characterized by having a high resolution, and then analyzing the inner structure thereof.Type: GrantFiled: June 22, 2015Date of Patent: July 21, 2020Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Naoko Senda, Kentaro Osawa
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Patent number: 10717963Abstract: The object of the present invention is to provide a method of culturing lactic acid bacteria to obtain a lactic acid bacteria culture in which the number of lactic acid bacteria can be stably maintained, and to obtain food and drink products comprising a lactic acid bacteria culture excellent in product stability. In order to accomplish the object, the present invention provides a method of culturing lactic acid bacteria comprising inoculating lactic acid bacteria to a medium comprising a milk ingredient having a free phosphoric acid concentration of less than 0.25 wt %, and a phosphate, and food and drink products comprising the lactic acid bacteria culture obtained by this culturing method.Type: GrantFiled: March 19, 2010Date of Patent: July 21, 2020Assignee: KABUSHIKI KAISHA YAKULT HONSHAInventors: Masatoshi Nakano, Mika Arifuku, Harumi Mizukoshi, Susumu Mizusawa, Kazumasa Kimura, Masahiko Ito
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Patent number: 10717964Abstract: A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.Type: GrantFiled: July 23, 2018Date of Patent: July 21, 2020Assignee: University of DelawareInventors: Eleftherios T. Papoutsakis, Sergios Nicolaou, Alan Fast, Vasiliki Falara, Robert Kyle Bennett, William Brian Whitaker, Nicholas Richard Sandoval, Jacqueline Gonzalez, Maciek Antoniewicz
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Patent number: 10717965Abstract: The present disclosure pertains to a mammalian cell culture genetically modified to express, and which expresses, a neublastin antibody polypeptide, or fragment thereof, in the culture, and to a neublastin antibody polypeptide, or fragment thereof, made by a mammalian cell culture genetically modified to express, and which expresses, the neublastin antibody polypeptide, or fragment thereof.Type: GrantFiled: December 21, 2018Date of Patent: July 21, 2020Assignee: Gloriana Therapeutics, Inc.Inventors: Alan Gilbert, Kyle McElearney, Terrence Michael Dobrowsky, Rashmi Rohit Kshirsagar
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Patent number: 10717966Abstract: The present disclosure provides co-cultures of human pluripotent stem cell derived hepatocytes and at least one non-parenchymal cell population in vitro, methods of preparing the co-cultures and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The stem cell derived hepatocyte co-culture system provides an in vitro model in which cell viability and relatively mature hepatocyte phenotype of stem cell derived hepatocytes are maintained for extended periods relative to conventional monoculture.Type: GrantFiled: October 11, 2018Date of Patent: July 21, 2020Assignee: COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Salman R. Khetani, Dustin R. Berger, Brenton R. Ware
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Patent number: 10717967Abstract: The present invention relates to DEV and the uses thereof. The invention is particularly suited to vaccinate poultry against avian pathogens.Type: GrantFiled: January 18, 2019Date of Patent: July 21, 2020Assignee: CEVA SANTE ANIMALEInventors: Saeki Yukari, Shuji Saitoh
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Patent number: 10717968Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.Type: GrantFiled: February 12, 2018Date of Patent: July 21, 2020Assignee: Pacific Biosciences of California, Inc.Inventors: David R. Rank, Paul S. Peluso, David K. Hanzel, Geoff Otto, Thang Pham, Fred Christians, Arekadiusz Bibillo, Insil Park, Sonya Clark, John Lyle
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Patent number: 10717969Abstract: The present invention relates to isolated polypeptides with lipase activity. The invention also relates to polynucleotides encoding the polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the polypeptides.Type: GrantFiled: November 8, 2018Date of Patent: July 21, 2020Assignee: NOVOZYMES A/SInventors: Ming Li, Tianqi Sun, Xianshi Jiang, Lone Baunsgaard, Carsten Hoerslev Hansen, Kim Borch, Han Bucong
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Patent number: 10717970Abstract: Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the sialylation and/or glycosylation of Factor VII and variants thereof produced peptides useful in treating conditions of acute bleeding.Type: GrantFiled: September 14, 2016Date of Patent: July 21, 2020Assignee: Coagulant Therapeutics CorporationInventors: Maxine Bauzon, Terry Hermiston
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Patent number: 10717971Abstract: A novel protein deamidase having an activity of directly acting on a side chain amide group of an asparagine residue in a protein to form a side chain carboxyl group and release ammonia, a microorganism that produces the same, a gene encoding the same, a method for producing the same, and use of the same are provided. A bacterium classified into the class Actinobacteria is cultured to generate protein deamidase, and the enzyme is collected from culture.Type: GrantFiled: August 31, 2016Date of Patent: July 21, 2020Assignee: AJINOMOTO CO., LTD.Inventors: Noriko Yokoyama, Mayu Nakano, Shuhei Hashiro, Masako Hiraga, Kazutaka Shimbo, Ayaka Tokunaga
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Patent number: 10717972Abstract: The present disclosure provides a genetically modified host cell capable of producing linalool (or 3,7-dimethylocta-1,6-dien-3-ol).Type: GrantFiled: December 9, 2016Date of Patent: July 21, 2020Assignee: The Regents of the University of CaliforniaInventors: Charles M. Denby, Jay D. Keasling, James Kirby, Rachel Alexandra Li
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Patent number: 10717973Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.Type: GrantFiled: December 6, 2018Date of Patent: July 21, 2020Assignee: BASF SEInventors: Michael Breuer, Bernhard Hauer, Dieter Jendrossek, Gabriele Siedenburg, Juergen Pleiss, Demet Sirim, Silvia Fadenrecht
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Patent number: 10717974Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.Type: GrantFiled: April 19, 2019Date of Patent: July 21, 2020Assignee: Codexis, Inc.Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
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Patent number: 10717975Abstract: Methods and compositions are described for selecting and identifying orthogonal aminoacyl synthetase-tRNA pairs and their use to incorporate unnatural amino acids in a site-specific manner in proteins. Specifically described is a novel E. coli tyrptophanyl synthetase-tRNA pair that functions as both an opal and amber suppressor and that incorporates tryptophan analogs into proteins.Type: GrantFiled: May 31, 2017Date of Patent: July 21, 2020Assignee: TRUSTEES OF BOSTON COLLEGEInventors: Abhishek Chatterjee, James Italia