Abstract: A dental curing light includes a device body that efficiently conducts heat away from the light emitting diode (LED) portion of the curing light. The device body is one-piece body formed from a continuous seamless piece of thermally conductive material extending between a proximal end and a distal end. The one-piece body includes a gripping handle portion extending to the proximal end and a light-emitting head portion extending to the distal end. The one-piece thermally conductive body acts as a heat sink to efficiently conduct heat away from the LED dies during use. The one-piece body eliminates problems of multi-segmented curing lights that include one or more joints between adjacent segments. Eliminating joints increases thermal conductivity of the body, eliminates crevices where microbes can grow, and eliminates the risk of accidental separation if the curing light is dropped.

Abstract: The present invention relates to a periodontal interdental tray and to a periodontal medicament tray syringe that can be used in conjunction with the periodontal interdental tray of the present invention, or can be utilized by itself or in conjunction with other periodontal trays already on the market. In one embodiment, the present invention relates to treatment of periodontal disease, and in particular to a dental tray syringe and method for delivering medicaments into areas of the mouth either supragingival or subgingivally to treat the infected areas.

Abstract: Materials for soft tissue repair, and in particular, material for hernia repair. These materials may be configured as an implant, such as a graft, that may be implanted into a patient in need thereof, such as a patient having a hernia or undergoing a hernia repair surgical procedure. These grafts may include a first layer comprising a substrate (e.g., mesh) and a second layer comprising a sheet of anti-adhesive material. The layers may be attached with a plurality of relatively small attachment sites that are separated by regions in which the two layers are not attached, to provide a highly compliant graft.

Abstract: Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a medical device includes an occluder portion and an anchor portion. The occluder portion includes a hub that defines an axis, the occluder portion extending between a proximal end coupled to the hub and a distal end defining an occluder eyelet adjacent thereto. The anchor portion extends between a first end and a second end, the first end coupled to an anchor hub and the second end defining an anchor eyelet adjacent thereto and hingeably coupled to the occluder eyelet. With this arrangement, the anchor hub is moveable along the axis to move the anchor portion between a retracted position and a deployed position upon the occluder portion being in an expanded position.

Abstract: A prosthetic heart valve delivery catheter includes an embolic filter to provide integrated embolic protection to inhibit the release of emboli into the aorta, the aortic arch or branch vessels, and other vasculature during transvascular heart valve replacement procedures. The embolic filter will usually be fixedly or movably attached to a shaft of the delivery catheter proximal of the prosthetic heart valve.

Abstract: A system includes a filling structure deployable at least partially in a common iliac artery and an external iliac artery, and a scaffold positioned within a first lumen of the filling structure. The scaffold has a fenestration in a side of the scaffold that is positionable toward an internal iliac artery. The filling structure has a second lumen extending from the first lumen and positionable toward the internal iliac artery. A method includes deploying a filling structure at least partially in a common iliac artery and an external iliac artery and positioning a scaffold within a lumen of the filling structure such that a fenestration in a side of the scaffold is positioned toward an internal iliac artery.

Abstract: An assembly and method for implanting a graft in a blood vessel of a patient including a graft having proximal and distal ends, with an expandable mesh positioned adjacent one of the ends and a cover extending from the proximal to distal ends. The graft may have a proximal removable sheath disposed over a portion of the graft corresponding to the proximal end and a distal removable sheath disposed over a portion of the graft corresponding to the distal end. Each sheath may be configured to compress the graft to an insertion diameter relative to a deployed diameter. The graft may be deployed by inserting the distal end of the graft through an opening in a wall of the blood vessel, removing the distal sheath and expanding the distal end of the graft from the insertion diameter to the deployed diameter to secure the graft within the blood vessel.

Abstract: An endoluminal graft system comprising an endoluminal graft including a framework and a flexible fabric surrounding the framework, a deflection means configured for placement through an opening to a branching vessel, and a delivery catheter configured to position the endoluminal graft within a primary vessel. A method of implanting the endoluminal graft includes positioning the endoluminal graft within a primary vessel with a leading edge of the endoluminal graft adjacent to an opening to a branching vessel. A deflecting means is positioned through the opening to the branching vessel adjacent to the leading edge of the endoluminal graft. The endoluminal graft is then advanced along the length of the primary vessel with the deflection means engaging the leading edge of the endoluminal graft to form a scallop along the leading edge of the endoluminal graft.

Abstract: A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Abstract: Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include acellular arterial tissue matrices that facilitate regrowth of the damaged tissue.

Abstract: Systems and methods for knotless tissue repair employ a first suture construct routed through a tissue in a first inverted mattress stitch, including a loop portion and two free limbs. The loop portion of the first suture construct so routed is positioned adjacent to a superior surface of the tissue and the free limbs of the first suture construct so routed extend through an inferior surface of the tissue. A second suture construct, separate from the first suture construct, is inserted within the loop portion of the first suture construct such that two free limbs of the second suture construct extend from the loop portion of the first suture construct. The second suture construct comprises a plurality of braided filaments and possesses a substantially rectangular cross-sectional profile, and does not include a suture core surrounded by the braided filaments.

Abstract: An artificial hair implant device is disclosed. The artificial hair implant device according to the present invention has: a body part having a hollow body; a head part in which a head is coupled and fixed to the body, an implant needle is provided to be able to enter and exit the head and has an artificial hair fitted around an end portion thereof that is drawn out from the head, and a return spring is provided between the implant needle and the head and returns the implant needle drawn out from the head back to an original position; and a button part in which a button is movably provided on the body, and a pressing shaft is provided under the button and enters and exits the body, thereby pressing the implant needle, such that the implant needle is drawn out from the head.

Abstract: A novel and advantageous implant device and methods for implanting the device are provided. Particularly, novel and advantageous devices and methods for breast reconstruction are provided. More particularly, novel and advantageous devices and methods for breast reconstruction to provide a more realistic form are provided.

Abstract: The present invention provides a keratoprosthesis assembly comprising a central optical core; and a peripheral skirt comprising at least one porous biocompatible layer and methods of using it in keratoprosthesis procedures.

Abstract: Methods for treating presbyopia in a patient's eye involve inducing spherical aberration in a central area of the pupil. In embodiments, refractive properties of an eye are measured to obtain a baseline refractive correction. A lens for wearing on the eye is provided, or an optical device is implanted in the eye, or corneal tissue is removed to create spherical aberration or a distribution of spherical aberrations beyond the baseline refractive correction in the central area of the pupil. The central area of the pupil has a diameter of between 1.5 mm and 4.0 mm and has negligible spherical aberration without the treatment.

Abstract: An example method for cutting a plurality of lenticules from a donor cornea includes receiving a donor cornea, cutting a first layer of a first set of lenticules from the donor cornea, and cutting a second layer of a second set of lenticules from the donor cornea. The lenticules are cut according to a pattern that to maximizes the number of lenticules, thereby maximizing the number of implants from the single donor cornea. An example implant handling device includes a body. The body includes a flattened end configured to receive a corneal implant and keep the corneal implant from rolling or folding. The flattened end has a width and a height, the width being greater than the height. The body includes a slit opening to the flattened end, the slit opening configured to allow the corneal implant to pass into the flattened end.

Abstract: Disclosed herein is an intraocular lens implantable in an eye comprising an optical portion adapted for placement in the lens capsule of the eye and for directing light toward the retina of the eye; an annular ring having an outer diameter and an inner diameter; and at least one elongated fixation member coupled to said optical portion for use in fixing said intraocular lens in the eye; where the outer diameter of the annular ring contacts the elongated fixation member and where the inner diameter of the annular ring contacts the optical portion of the intraocular lens; and where the entire intraocular lens is a single monolithic piece.

Abstract: A method and system provide an ophthalmic device. The ophthalmic device includes an ophthalmic lens having an anterior surface, a posterior surface, at least one diffractive structure and at least one base curvature. The at least one diffractive structure for provides a first spherical aberration for a first focus corresponding to at least a first focal length. The at least one base curvature provides a second spherical aberration for at least a second focus corresponding to at least a second focal length. The first spherical aberration and the second spherical aberration are provided such that the first focus has a first focus spherical aberration and the second focus has a second focus spherical aberration. The first focus spherical aberration is opposite in sign to the second focus spherical aberration.

Abstract: Systems and methods can advantageously leverage the pupillary accommodation reflex to provide improved quality of vision throughout the range of focus distances. As such, some embodiments include an accommodating pupillary lens (APL) that sits at least partially within the pupil and/or is partially or fully attached, adhered, or otherwise held in place with respect to the iris, and/or is anchored in the sulcus and/or elsewhere in the eye. The optical power of the lens can be configured to change with changes in pupil diameter.

Abstract: An accommodating intraocular lens implant includes an anterior floating lens unit, a posterior lens unit, an anterior rim complex disposed such that the anterior floating lens unit is movable toward and away from the anterior rim complex. A plurality of levers are in jointed connection with: the anterior floating lens unit at respective first longitudinal sites along the levers, the anterior rim complex at respective second longitudinal sites along the levers, and the posterior lens unit at respective third longitudinal sites along the levers. The respective second longitudinal sites are longitudinally between the respective first and the respective third longitudinal sites. The levers are arranged (a) such that the third longitudinal sites serve as respective fulcrums for the plurality of levers, and (b) to move the anterior floating lens unit toward and away from the anterior rim complex, in the anterior-posterior direction. Other embodiments are also described.

Abstract: A method and system provide an ophthalmic lens including a lens body having a chamber therein, a reservoir module coupled with the lens body and an optical fluid. At least part of the lens body is flexible. The reservoir module includes a reservoir and a heat sensitive portion bordering the reservoir. The reservoir has a reservoir volume and is fluidically connected with the chamber. The heat sensitive portion has a shape responsive to a temperature of at least forty five degrees Celsius such that the reservoir volume changes in response to at least part of the heat sensitive portion reaching the temperature. The optical fluid resides in the chamber and the reservoir. A change in the reservoir volume flows a portion of the optical fluid between the reservoir and the chamber such that the flexible portion of the lens body undergoes a shape change corresponding to a base power change.

Abstract: A method for non-surgically treating an internal nasal valve of a patient comprising, injecting a working device into the internal nasal valve of the patient, wherein the injected working device in the nasal tissue causes an alteration of an internal or external nasal valve. A device introduced by injection into the nose, allowing for structural support or filling of defects in the nose, and causing a change in external shape of the nose. The device and inserts and implants described also have use in cosmetic applications relating to the facial tissue.

Abstract: Various aspects of the disclosure relate to a tracheal implant comprising (a) a trachea processed to comprise one or more incisions providing a helical configuration to the processed trachea; and (b) a subject-specific synthetic support.

Abstract: A covering layer for a transcatheter heart valve is in various embodiments configured to prevent or reduce damage to the native valve tissue around the site where the prosthetic valve is implanted. In some cases, prosthetic valves are manufactured with the covering layer attached. Other covering layers are stand-alone accessories that can be mounted onto pre-existing prosthetic valves by an end user. Covering layers that can be mounted by an end user are provided with various features that can facilitate easier attachment of the covering layer to the prosthetic valve, which further reduces the possibility of damage to the covering layer or to the valve. Another covering is provided with two layers in order to insulate and protect the native tissue surrounding the implant from damage due to friction or abrasion, and/or other movement driven wear.

Abstract: Embodiments of universal self-anchoring prosthetic valves for multi-position transcatheter or surgical implantation within any diseased or malfunctioning native heart valve are provided. An exemplary embodiment of a prosthetic valve includes a radially compressible and self-expanding central core housing a prosthetic valve, with compressible and flexible memory-shaped woven wire anchoring discs at the inflow and outflow ends. Specific design properties allow the prosthesis to be conformable, self-centering and flipped for multiple appropriate physiologic implant orientations. Expansive transverse radial force exerted by the central core, and memory-shape induced directional forces exerted by flexible inflow and outflow discs, capture and compress native peri-annular and leaflet tissues to anchor the prosthesis. Tissue facing frame surfaces may include small tines to enhance anchoring. The prosthetic valve frames may include various biomaterials or polymers as linings, coatings or coverings to enhance sealing.

Abstract: A catheter, advanced toward an anatomical site, has a proximal end and a steerable distal end. An anchor is advanced through the catheter. An anchor driver drives the anchor out of the catheter's distal end, anchoring the anchor at the site. A first constraining member engages tissue, and inhibits, after the anchor has been driven out of the catheter and before the anchoring, movement of at least the anchor driver's distal end, on a first axis between the anchor driver's distal end and a site at which the first constraining member engages the tissue. A second constraining member inhibits, after the anchor has been driven out of the catheter and before the anchoring, movement of at least the anchor driver's distal end, on a second axis. Other embodiments are also described.

Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The delivery system can include a number of advantageous steering and delivery features, in particular for the transseptal delivery approach.

Abstract: The present invention relates to a tissue shaping device adapted to be disposed in a vessel near a patient's heart to reshape the patient's heart. The device comprises a first anchor and a second anchor adapted to be deployed by a catheter to engage a vessel wall while the first anchor is adapted to resist the compression of a first part of the first anchor and resist the expansion of a second part of the first anchor in response to a compressive force on the first part.

Abstract: Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

Abstract: A delivery system for delivery of a radially expandable device to an implantation site in a patient, the delivery system including an elongated tubular member comprising a distal tip and an outer surface, first and second balloon portions spaced proximally from each other and the distal tip along a length of the tubular member, an annular space between the first and second balloon portions, a plurality of clip deployment tubes extendably moveable relative to the outer surface of the tubular member, and a plurality of clips, wherein each clip is moveable within a length of one of the clip deployment tubes between a retracted position and a deployed position.

Abstract: A modular medical testing device at least two driving motor modules, wherein the motors are separately controlled.

Abstract: Lamina plate assemblies, systems, and methods thereof. A lamina plate assembly may be configured to provide lamina support following laminectomy, for example, in cervical and lumbar cases. The lamina plate assembly may include a generally elongate body having a first free end, a second free end, and a posterior portion disposed between the first free end and the second free end. Different embodiments of securing portions are used to secure the lamina plate assembly to a vertebra.

Abstract: The application is directed to devices and methods where one or more magnetic or magnetizable implants provides therapeutic benefits to a patient. The implant may be useful for expanding the range of motion of joints or dynamically providing different responses to changing conditions in the body where the implant is placed. An electromagnet is placed on or in a bone on one side of a joint, and another electromagnet or magnetically active material is placed on or in a bone on the opposing side of the joint. The electromagnet may be continuously energized to relieve pressure in the joint space, or may be energized in response to forces applied to the joint.

Abstract: The invention pertains to surface topographies which can be used to modulate the morphology, proliferation, biochemical functioning, differentiation, attachment, migration, signaling, and/or cell death of a cell population by physical stimulation. Such topographies can be applied in vitro and in vivo to modulate cell behavior. Specific examples include implants provided with a topography of the invention which regulates the immune response, or an implant which increases osteogenesis. The invention furthermore pertains to objects which are used in vitro to modulate cell behavior.

Abstract: A stem (3) includes: a body section (10) which is inserted into a narrowing hole (Ha) formed in a femur (H) and osseointegrated; a neck section (20) which is joined to a tip of the body section (10) and protrudes from the narrowing hole (Ha) to transmit a load from an acetabular side to the body section (10); and a leg section (25) which is joined to a distal end of the body section (10) to hold a posture of the body section (10), wherein the neck section (20) and the leg section (25) are made of a biocompatible resin, and the body section (10) is made of a biocompatible metal, a biocompatible ceramic, or a biocompatible resin.

Abstract: The present invention involves orthopedic implants of small joints in human, in particular a truly patient-specific bone implanting system comprising the implant and surgical tools fabricated by additive manufacturing techniques based on the inputs conforming to each patient's anatomy and obtainable from a wide range of existing 3-dimensional imaging and image processing technologies, which offers a substantial progress in logistics, efficiency of surgical operation, and functionality of treated bones.

Abstract: The present disclosure provides knee prostheses that replicate at least a portion of the function of an individual patient's anterior cruciate ligament (ACL). An exemplary knee prosthesis includes a femoral component configured to be implanted on the distal end of the patient's femur and a tibial component configured to be implanted on the proximal end of the patient's tibia. In extension, the femoral component and the tibial component may cooperate to limit anterior movement of the tibial component relative to the femoral component. In flexion, the femoral component may be free to rotate relative to the tibial component.

Abstract: A glenoid component includes a body, a first, convex surface, a second, concave surface, a third surface connecting the first and second surfaces, a channel, and at least one alignment member. The channel extends from a first channel opening of the first surface through the body to a second channel opening defined on the third surface and has a channel axis extending through the first and second channel openings. The channel axis intersects a first plane defined by the first channel opening at an angle transverse to the first plane. The channel is configured to receive a bone engagement member to attach the body to a shoulder bone. The at least one alignment member extends from the first surface to align the body to the shoulder bone. The bone engagement member can attach the body to the shoulder bone.

Abstract: Embodiments are directed to a spinal implant device for reducing effects of a spinal disc herniation that includes a support frame, where the support frame has a first end, a second end, and a mounting hole for receiving a fastener that attaches the support frame to a vertebra, and a cushion attached to the support frame. Embodiments are also directed to a system for implanting a medical device to a spine that includes a spinal implant device having a support frame, where the support frame has a first end, a second end, and a mounting hole, and a cushion attached to the support frame. The system also includes a fastener for attaching the spinal implant device to a vertebra, where the spinal implant device is moveable to align the cushion to a disc space created after a portion of a herniated disc is removed during surgery.

Abstract: Disclosed is an expandable interbody fusion implant that is configured to have an initial configuration having a first footprint width suitable for being inserted into an intervertebral space and an expanded configuration having a second footprint width that is greater than the first footprint width. The implant may include a first body member and a second body member that is pivotally coupled to the first body member. The implant may be expanded using an inflatable balloon. The implant may be expanded bilaterally such that both body members rotate relative to the other or the implant may be expanded unilaterally such that one of the body members rotates relative to the other.

Abstract: A spinal implant includes a body having an inner surface and a connecting wall. The inner surface defines at least one cavity and the connecting wall is disposed about the at least one cavity. The connecting wall defines at least one opening. An agent is disposable with the at least one cavity. Spinal constructs, surgical instruments, systems and methods are disclosed.

Abstract: An implant includes a body and a bone fixation system. The body includes an interior area disposed between a superior surface and an opposite inferior surface spaced from the superior surface in a vertical direction. In addition, the bone fixation system includes at least one blade disposed within the interior area of the body in an insertion position. Also, the bone fixation system further includes at least one strike plate engaging the at least one blade in the interior area of the body, the at least one strike plate being configured to move the at least one blade from the insertion position to an impaction position in which at least a portion of the blade protrudes past one of the superior surface and inferior surface of the body.

Abstract: A self-drilling bone fusion screw apparatus is disclosed which includes at least first and second sliding boxes. A first screw member having a tapered end and a threaded body is disposed within the first sliding box, and a second screw member having a tapered end and a threaded body disposed within the second sliding box. An adjuster adjusts the height of the sliding boxes. The screw members are screwed into vertebral bodies in order to fuse the vertebral bodies together. A plurality of the self-drilling bone fusion screw apparatuses may be attached together and/or integrated via a plate or cage. Also disclosed is a cervical facet staple that includes a curved staple base and at least two prongs attached to the bottom surface of the curved staple base.

Abstract: A bone fusion method, apparatus and device for insertion between bones that are to be fused together and/or in place of one or more of the bones, such as, for example, the vertebrae of a spinal column. The bone fusion device comprises one or more extendable plates having a central rib. The bone fusion device includes one or more support channels configured to receive an insertion instrument that is then secured to the bone fusion device via a coupling mechanism. As a result, the coupled device is able to be securely positioned between vertebrae using the insertion instrument with minimal risk of slippage.

Abstract: A stemless humeral component for replacing the humeral head of a patient's humerus includes a support flange having a number of cantilevered legs extending distally away from a bottom surface thereof. Instruments and methods for surgically installing the stemless humeral component are also disclosed.

Abstract: A two-part prosthetic socket which includes an inner socket component having an inner profile substantially complementary to a profile of a residual limb of a patient, and an outer socket component configured to releasably attach about an outer surface of the inner socket component is disclosed. The inner profile of the inner socket component may be determined from digital data output from a medical imaging scan of the residual limb, which provides a three-dimensional digital profile of the residual limb that includes information on the size and location of at least bone and bone spurs, muscle, scar tissue, and neuroma. The digital data may further include a designed operating range for the size and shape of the three-dimensional digital profile of the residual limb based on such information. The two-part prosthetic socket may be manufactured using additive manufacturing, wherein the inner socket may be formed of a flexible material and the outer socket may be formed of a rigid material.

Abstract: A system and method for controlling a device, such as a virtual reality (VR) and/or a prosthetic limb are provided. A biomimetic controller of the system comprises a signal processor and a musculoskeletal model. The signal processor processes M biological signals received from a residual limb to transform the M biological signals into N activation signals, where M and N are integers and M is less than N. The musculoskeletal model transforms the N activation signals into intended motion signals. A prosthesis controller transforms the intended motion signals into three or more control signals that are outputted from an output port of the prosthesis controller. A controlled device receives the control signals and performs one or more tasks in accordance with the control signals.

Abstract: A manufacturing process forms a bored hollow lumen. The manufacturing process includes providing a solid rod of a bioresorbable material and boring a hole axially through the solid rod. The manufacturing process also includes modifying surface defects formed on a luminal surface by the boring, the luminal surface defining the hole, thereby forming the bored hollow lumen. A bored hollow lumen includes a lumen wall including a bioresorbable material. The lumen wall has an abluminal surface and a luminal surface. The luminal surface defines a bore through the bored hollow lumen. The bioresorbable material has a uniform crosslinking density.

Abstract: Devices and methods for protecting the neurovascular structures about the vertebral column are provided. One embodiment of the invention comprises a neuroprotective stent or device adapted for placement in an intervertebral foramen of a vertebral column and configured to resist compression or impingement from surrounding structures or forces. The stent or device may further comprise a flange or hinge region to facilitate attachment of the device to the vertebrae or to facilitate insertion of the device in the foramen, respectively.

Abstract: Apparatus and methods are described, including a stent configured to be placed in a lumen. The stent includes a generally cylindrical stent body including a plurality of struts, at least one electrode post protruding from the stent body, and a plurality of antenna posts protruding longitudinally from an end of the stent body. The antenna posts are longitudinally separated from the electrode post. An antenna is disposed annularly on the antenna posts, such that the antenna posts separate the antenna from the end of the stent body, and at least one electrode is coupled to the stent by being placed on the electrode post. Additional embodiments are also described.