Abstract: Systems and methods for high frequency impedance spectroscopy detection of daily changes of dielectric properties of the human body to measure body composition and hydration status. According to an aspect, a method at a computing device to determine a set of indirect dynamic human metabolism parameters includes using a sensor on an individual to acquire a set of electrical measurements. The method also includes combining a ratio technique with a canonical model form technique. The also includes performing a series of mathematical calculations on the acquired set of electrical measurements to determine the set of indirect dynamic human metabolism parameters for the individual based on the combined ratio technique and the canonical model form technique.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an integrin inhibitor. In an exemplary embodiment, a pharmaceutical formulation that comprises the medicaments is released from an ingestible device at a location in the gastrointestinal tract that is proximate to one or more sites of disease.

Abstract: Systems and methods measure impedance across a user's chest during respiration to determine a rate of respiration. With AC-modulation contacts separated from impedance-measuring contacts, analog filtering to remove EMI, a bridging capacitor to remove DC noise, and digital filtering to further remove EMI, a user's respiration may be measured with the AC-modulation contacts and the impedance-measuring contacts placed at user extremities.

Abstract: Embodiments of the present disclosure provide respiration monitoring systems and methods for using same. The respiration monitoring device can include a first accelerometer, a second accelerometer, at least one acoustic sensor, a memory comprising a lookup table, a real-time clock, and one or more instructions, and a processor for receiving one or more motion signals from each accelerometer and one or more sound signals from each acoustic sensor. The processor can correlate the one or more motion signals to a distance value, correlate the one or more sound signals to a sound value, filter the distance value and the sound value according to limitations stored in the lookup table, assign a time stamp to each filtered value, determine local maximums for the filtered motion values and local minimums for the filtered sound values, and match the local maximums to the local minimums to confirm a completed breath.

Abstract: Respiratory rate can be calculated from an acoustic input signal using time domain and frequency domain techniques. Confidence in the calculated respiratory rate can also be calculated using time domain and frequency domain techniques. Overall respiratory rate and confidence values can be obtained from the time and frequency domain calculations. The overall respiratory rate and confidence values can be output for presentation to a clinician.

Abstract: A clothing protection system for protecting elderly people from falls and for monitoring data captured by the clothing protection system. The clothing protection system includes an article of clothing having at least one hidden pocket for holding a pad element. The at least one hidden pocket and the pad element are positioned adjacent to an impact point of the elderly person. The clothing protection system also includes at least one sensor supported by the article of clothing. The sensor can be positioned in close proximity to the pad element to monitor movement of the elderly person. A method of collecting and monitoring data related to falls of elderly people includes the step of implementing a clothing protection system for an elderly person. The method also includes the step of receiving fall data from the clothing protection system responsive to a fall for the elderly person.

Abstract: In an example, the present invention provides an UWB and FMCW sensor apparatus, with an audio module and inertial motion module, using multi-core processing and an AI processor.

Abstract: Described are methods and devices (100) for measuring a sweat property of skin (12) in response to at least one test material or component (172, 174, 176, 178). Embodiments of the device include a plurality of different sweat stimulation sites. The Sweat stimulation sites may include one or more sweat stimulant reservoirs (142, 144, 146, 148) configured to deliver a sweat stimulant to the surface of the skin (12). Embodiments may also include at least one electrode (150, 152, 154, 156, 158) for measuring a sweat property or to iontophoretically deliver the sweat stimulant from the reservoir (142, 144, 146, 148). In embodiments, the sweat stimulant is selected from acetylcholine, carbachol, methacholine, bethanechol, muscarine, pilocarpine, oxotremorine, and combinations thereof.

Abstract: Systems and methods are described herein for utilizing a photoacoustic sensor for estimating analyte concentration levels. Also described here are training methods for training an analyte sensor to more accurately estimate an analyte concentration level on the basis of a received acoustic signal.

Abstract: There is provided a system for measuring a property of a sample that comprises a test strip for collecting the sample; a diagnostic measuring device configured to receive the test strip and measure a concentration of an analyte in the sample received on the test strip; and the diagnostic measuring device further comprising a processor programmed to execute an analyte correction for correcting a measurement of the sample due to one or more interferents, comprising: calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a switched capacitor accumulator to measure a phase angle; and adjusting the measurement of the analyte in the sample using that the calculated interferent impedance measurement.

Abstract: A method for adjusting a bolus amount of insulin for a meal event using a control unit having a processing unit and a touch screen display as well as a medical control device and a medical system configured to perform the method. Additionally, the present disclosure relates to a computer program or computer program product that, when executed, performs the method. A carbohydrate-based bolus amount of insulin can be delivered in a first bolus and a second bolus. A movable slider displayed on the touch screen display can be used to adjust the relative amounts of the first and second boli.

Abstract: A customizable pulse oximetry assembly is disclosed. The assembly include a bandage with a first receptacle, a second receptacle, and a flexible connector connecting the first receptacle and the second receptacle. The assembly also includes a light emitter having a first probe housing for removably mounting the light emitter on the first receptacle and a light sensor comprising a second probe housing for removably mounting on the second receptacle. A cable connector for physically coupling the light emitter and the light sensor and for communicatively coupling the light emitter and the light sensor to a patient monitor is included as a part of the assembly. The flexible connector, the first probe housing, and the second probe housing may be adapted to adjust for a separation and an alignment between the light emitter and the light sensor according to a dimension of a patient body part.

Abstract: A device may identify a peak timestamp and a trough timestamp based on a first principal component of photoplethysmography (PPG) data associated with a plurality of wavelength channels. The device may generate a peak absorption spectrum based on the peak timestamp and the PPG data, and may generate a trough absorption spectrum based on the trough timestamp and the PPG data. The device may determine a measured arterial blood spectrum based on the peak absorption spectrum and the trough absorption spectrum. The device may fit the arterial blood spectrum model to the measured arterial blood spectrum to determine a set of values, each value in the set of values corresponding to a variable in a set of variables. The device may calculate an arterial oxygen saturation value based on one or more values of the set of values.

Abstract: A sensor cover according to embodiments of the disclosure is capable of being used with a non-invasive physiological sensor, such as a pulse oximetry sensor. Certain embodiments of the sensor cover reduce or eliminate false readings from the sensor when the sensor is not in use, for example, by blocking a light detecting component of a pulse oximeter sensor when the pulse oximeter sensor is active but not in use. Further, embodiments of the sensor cover can prevent damage to the sensor. Additionally, embodiments of the sensor cover prevent contamination of the sensor.

Abstract: A reusable sensor is disclosed for producing a signal indicative of at least one physiological parameter of tissue. The sensor can include a sensor housing that has a distal opening, a wire lumen, and a proximal opening. The distal opening can include a lumen extending through the body of the sensor housing and the wire lumen can be located on the outside of the sensor housing. The sensor can also include a first component located on a top surface of the sensor housing and along the pathway of the wire lumen. The sensor can also include a second component located on the bottom surface of the sensor housing opposite of the first component. The second component can also be located along the pathway of the wire lumen. The sensor can also include a wire coaxially disposed within the wire lumen and connecting the first component and second component.

Abstract: Disclosed are self-powering biofuel cell and sensor devices, systems and techniques. In some aspects, a self-powered biosensing system includes an electronic circuit; an anode including an enzymatic layer electrically coupled to a power supply voltage terminal of the electronic circuit and configured to interact with an analyte in a fluid, such as glucose or lactate; and a cathode electrically coupled to a ground voltage terminal of the electronic circuit, where the electronic circuit is operable to control and use the electrical energy generated at the anode and cathode for powering the biosensing system and detecting a concentration of the analyte in the fluid.

Abstract: A biological fluid collection device that includes a housing and a cartridge that is removably receivable within a portion of the housing is disclosed. The biological fluid collection device of the present disclosure allows for collection of capillary blood from a finger stick and provides a closed system that reduces the exposure of a blood sample. In one embodiment, a cartridge of the present disclosure also provides fast mixing of a blood sample with a sample stabilizer. In another embodiment, a cartridge of the present disclosure provides automatic plasma separation of the blood sample. Advantageously, once the cartridge is filled with a sample aid removed from the housing, the cartridge can be used for a variety of important purposes.

Abstract: Disclosed herein is a platform and method to quantify spatiotemporal tissue swelling during biologics injection, and to predict associated increase in the mechanical stress and interstitial fluid pressure (IFP) of tissues. Accurate measure and estimation of tissue swelling, thus, can be quantitative and predictive indicator of the IPD.

Abstract: A lancing device with rear adjustment of penetration depth includes a cap, cap holder, ejection pin and shell, wherein: the lancing device has an external and medium depth adjusting sleeve. The ejection pin is located in the medium sleeve and the external depth adjusting sleeve is sleeved outside the medium sleeve; the external sleeve connects axially and circumferentially to the shell, and a rotary locating mechanism is between the external sleeve and the shell; the medium sleeve is connected circumferentially and axially in a sliding way, and a rotary moving mechanism is between the medium the external sleeve, and the medium includes a passive impact face relative to the active impact face of the ejection pin; the external sleeve includes a manual adjusting ring outside the lancing device at the middle and rear part, and rotates to drive the medium sleeve to move axially, changing the needle tip penetration depth.

Abstract: An apparatus includes a housing that defines a fluid reservoir and includes a port that is in fluid communication with the fluid reservoir. An inlet adapter is removably coupleable to the housing. A user can engage an actuator to move a plunger from a first position in which the fluid reservoir has a first volume, to a second position in which the fluid reservoir has a second volume greater than the first volume, which draws bodily fluid into the fluid reservoir via the inlet adapter. The actuator modulates a plunger rate of motion below a threshold as the plunger is moved. When a predetermined volume of bodily fluid is transferred into the fluid reservoir, a volume indicator transitions from a first state to a second state and the inlet adapter can then be removed to transfer the predetermined volume into a sample bottle external to the housing via the port.

Abstract: A medical device with a capacitive sensing function includes a medical body having a syringe and a sensing circuit having an electrode, a protective film adhered to the medical body and including a plastic film, an electrode provided on the plastic film and opposite from the electrode of the medical body, and a capacitive sensor formed by the electrode of the medical body and the electrode of the protective film and being a part of the sensing circuit, wherein a capacitance value of the capacitive sensor changed under the condition of removing the protective film from the medical body, the sensing circuit being configured to detect the capacitance value and trigger corresponding function of the medical body.

Abstract: A method is disclosed for testing hearing in infants based on pupil dilation response. It does not require sedation or depend on subjective judgments of human testers. Pupil dilation response to sound is measured by presenting on a display a visually engaging video containing periodic changes; presenting sounds synchronized with the periodic changes of the video; recording images from a camera directed in front of the display, where the camera is sensitive to infrared wavelengths; processing the images to measure pupil sizes; and processing the measured pupil sizes to determine, statistically, the presence of a pupil dilation response to the sounds.

Abstract: An interactive multi-purpose interactive cognitive platform is provided that uses image-based interactivities and may use enriched visual stimuli for diagnoses, treatment, and to evaluate and assess the progress and/or treatment of cognitive diseases and/or conditions with cognitive impacts. The platform may be used for performance enhancement training. The platform may include a graphical user interface. The platform is designed to cooperatively engage multiple cognitive domains using interactivities-embedded assessments. The images and image sets may involve the application of Gestalt principles for assessments and may be personalized address individual user preferences. The multi-purpose interactive cognitive platform may be used to produce diagnostics and/or treatment plans for specific cognitive conditions and diseases with a cognitive component.

Abstract: A method of providing hygiene services to a patient. The method includes acquiring patient status data of a patient with a sensor. Incontinence event data is acquired with an incontinence detection system. After the occurrence of the incontinence event, a sleep status of the patient is determined based the patient status data. A time period to provide hygiene services to the patient is determined based on the incontinence event data and the sleep status of the patient.

Abstract: A urodynamic investigation apparatus for receipt of urine from a bladder is provided. The apparatus is characterized by a tubular element, first and second fittings, and a sleeve element, for select passage of urine there through, within the tubular element. The tubular element is characterized by opposing first and second end portions, and a port. The fittings are adapted to be received by the opposing end portions of the tubular element so as to delimit an apparatus chamber. The sleeve element, suspended between the fittings within the chamber, has collapsed and open configurations. The collapsed configuration is indicative of a no urine flow condition, and the open configuration indicative of a urine flow condition, with the sleeve element urine flow condition being a function of pressure applied to the chamber via the port of the tubular element.

Abstract: There is provided a urine analysis device for bed side monitoring of a patient, comprising: an inlet sized and shaped for fluid communication with a urine collecting tube that receives urine from a patient; a drip chamber through which the urine flows towards an outlet; at least one sensor that analyzes each drop of urine and estimates a respective volume of each drop; a timing element that measures a reference time for each drop; a program store storing code; and at least one processing unit coupled to the program store for implementing the stored code, the code comprising: code to calculate a urine output flow rate of the urine output flowing through the chamber according to the estimated volume of each drop of the urine and the reference time for each drop; and code to output the urine output flow rate.

Abstract: Methods, devices and systems for evaluating olfactory function are configured to: electronically estimate a user-specific odorant detection threshold sensitivity threshold using at least one target stimulus odorant delivered to a nose of a user; flowably deliver a plurality of different target stimulus odorants to the nose of the user with defined concentrations of the different target stimulus odorants based, at least in part, on the estimated user-specific odorant detection sensitivity threshold; and evaluate olfactory function of the user based on the user's response to the delivered different target stimulus odorants.

Abstract: A telestroke eye examination accessory device, a system incorporating the same, and methods of using the same, are described. The telestroke eye examination accessory device includes eyewear having a first eye well and a second eye well, a first camera positioned within the first eye well, a second camera positioned within the second eye well, a first light array having lights in each of four different quardrants in the first eye well, and a second light array having lights in each of four different quadrants in the second eye well. The system further includes a graphical user interface useful for a practitioner using the telestroke eye examination accessory device to assess the field of vision of a patient wearing the eyewear.

Abstract: An apparatus, module, methods and systems for automated, standardized assessment and analysis of a human olfactory system's odor detection ability as an indicator or predictor of cognitive impairment or change in cognitive health, and other health conditions such as diabetes. Notably, the present invention is operable for use across all age groups of humans and provides quantitative detection and analysis of a human olfactory system's detection ability compared to a relevant demographic population.

Abstract: Apparatus and associated methods relate to diagnostic device and system including a proximal balloon disposed along a length of a catheter and a distal balloon disposed at a distal end of the catheter, with at least one camera disposed at the distal balloon and a pH sensor deployable via inflation of the proximal balloon and configured to engage a patient's esophagus wall to attach the pH sensor to the patient's esophagus wall. In an illustrative example, the pH sensor may be releasably retained to the catheter adjacent to the proximal balloon. The pH sensor may include a tissue engaging feature configured to engage a patient's esophagus wall to attach the pH sensor to the patient's esophagus wall. The diagnostic device may improve upon existing processes by providing a single device to perform a multi-purpose diagnostic procedure.

Abstract: A non-invasive colon motility monitoring system comprises an electrobioimpedance unit, an electromyography unit, and a computing device. The electrobioimpedance unit measures an impedance of a body of a subject and communicates an impedance signal that varies according to the measured impedance. The electromyography unit measures an electric voltage of the body of the subject and communicates a voltage signal that varies according to the measured voltage. The computing device includes a processing element programmed to receive the impedance signal and determine impedance data from the impedance signal, receive the voltage signal and determine voltage data from the voltage signal, compute impedance derivative data from the impedance data, compute a correlation between any two of the impedance data, the voltage data, and the impedance derivative data, determine when a bowel event is about to occur based on the correlation, and provide an indication of the bowel event.

Abstract: A method and device for measuring intra-abdominal pressure in a pregnant woman to assess likelihood or occurrence of pre-eclampsia The method includes providing a catheter having first and second lumens and a balloon, inserting the catheter into a bladder of the patient, injecting gas into the first lumen of the catheter to expand the balloon, obtaining a first pressure reading of the bladder based on deformation of the balloon to thereby monitor pressure within an abdomen of the mother to assess if pre-eclampsia is occurring or likely to occur and transmitting the first pressure reading to an external monitor connected to the catheter. The pressure reading is indicative of the presence and/or risk of pre-eclampsia to determine when intervention should occur to prevent morbidity and mortality of the woman and baby.

Abstract: A method of determining a skin health score for a first subject, the method comprising the steps of assessing the health of the skin of a subject using a plurality of measurement systems, each of the plurality of measurement systems configured to provide a first score characteristic of the health of the skin of the subject as determined by said measurement system, and calculating a second score based on a combination of each of the plurality of first scores, said second score indicative of a skin health score for the first subject.

Abstract: The present disclosure relates to a device and method for detecting chemicals from tissue, such as skin, comprising at least a first detector (A) and at least a second detector (B), wherein the first detector (A) and the second detector (B) are the same type of detectors. An attachment portion (C3) including at least the first detector (A) and at least the second detector (B) separated by a defined distance, the attachment portion is configured to be attached on the tissue for detection of the chemicals.

Abstract: A system for detecting pressure sores includes an artificial skin configured to be coupled to a patient's skin. The artificial skin includes a substrate and a strain sensor configured to detect deformation of the substrate. A transmitter is configured to transmit signals indicative of the deformation of the substrate. A control system is configured to receive the signals from the transmitter. The control system includes a timer to track a period of time that the substrate is deformed.

Abstract: Provided herein are methods to predict pain sensitivity and pain intensity to prolonged pain in a subject. Electroencephalograms are recorded in a pain-free state or, alternatively, in a pain-free state and after applying a prolonged pain stimulus in a prolonged pain state. Pain-free and prolonged pain peak alpha frequencies or ?PAF are measured. These values correlate negatively with the likelihood of increased pain sensitivity and increased pain intensity. Also provided is a method for predicting a likelihood of chronic pain in a subject after a medical procedure and designing a plan to treat the chronic pain.

Abstract: The present invention is provided to notify a person who makes a movement of a part to be improved in the movement. A movement evaluation system includes: a proficiency degree estimating unit generating a proficiency degree score on the basis of movement data obtained by detecting a movement of a user; an improvement point extracting unit specifying a part of the movement of the user as an improvement point on the basis of the movement data; and an information generating unit generating suggestion information to be presented to the user, on the basis of the improvement point.

Abstract: A method and system for determining training status of a user from exercises using a device with a heart rate sensor, a processor, memory, an output device and software. The training status is selected from a fixed group of alternatives. Each exercise is monitored using the heart rate sensor. Chosen exercise characteristics of each executed exercise are determined using obtained heart rate data and the determined characteristics of each executed exercise are stored in a memory. The chosen exercise characteristics include values of at least following variables: a date of the exercise, a value depicting physical readiness level for exercise during the exercise, a value depicting a training load of the exercise. When the exercises have been executed, values of selection variables are calculated using the stored exercise characteristics in the memory.

Abstract: A system for determining a location of a structure within a patients vasculature includes three or more pads adhered to the patients torso in a predetermined pad pattern. Each pad generates a pad electrical signal. A stylet has longitudinally spaced proximal and distal stylet ends, with at least one stylet electrode located proximate the distal stylet end. The stylet electrode receives the pad electrical signals and responsively generates a stylet electrical signal. A signal processor is operatively coupled for signal exchange with the stylet and to each of the pads via a selective electrical coupling. The signal processor compares the stylet electrical signal and at least two pad electrical signals to triangulate a position of the stylet electrode relative to each of the pads and responsively produce a triangulated position. The triangulated position is indicative of a position of the stylet electrode within the patients vasculature.

Abstract: The present disclosure describes systems and methods of estimating sedation level of a patient using machine learning. For example, the integration of multiple QEEG features into a single sedation level estimation system using machine learning could result in a significant improvement in the predictability of the levels of sedation, independent of the sedative drug used. The present disclosure advantageously allows for the incorporation of large numbers of QEEG features and machine learning into the next-generation monitors of sedation level. Different QEEG features may be selected for different sedation drugs, such as propofol, sevoflurane and dexmedetomidine groups. The sedation level estimation system can maintain a high performance for detecting MOAA/S, independent of the drug used.

Abstract: A method is described for making determinations on or classifying the pain of an estimation subject on the basis of the brainwaves of the estimation subject. This method includes: (a) stimulating the estimation subject at a plurality of levels of stimulation intensity; (b) acquiring brainwave data for the estimation subject; (c) extracting a brainwave feature quantity from the brainwave data or the analysis data; (d) for plugging the feature quantity into a Sparse model analysis, making the feature quantity approach a quantitative level and/or a qualitative level for pain, and estimating or making a determination on a pain level. Another method is described including comparing of brainwave data or analysis data from the 2,000 msec following the earliest of an induced brainwave component, an initial-event-related voltage component, and 250 msec after a target stimulus has been applied.

Abstract: A physical area network described herein enables significantly improved health monitoring and treatment by utilizing internal (in-body) mechanisms and information and external mechanisms and information.

Abstract: Devices, systems and methods are provided to assist with the monitoring or management of a patient's medical condition, which have one or more sensors sensing individual patient data on or near the patient. This individual patient data corresponds to at least one physiological parameter of the patient and includes a sensor that does not require the patient to apply it or activate it. The data is then transmitted to a processor for computing a risk or status signal that is based on comparison from a baseline related to a patient or related population and an alert or alarm can be generated based on the result of the signal.

Abstract: Presented are concepts for m classifying a disease or disability of a subject. One such concept comprises obtaining interaction data associated with a subject, the interaction data being representative of the subject's interaction with a movement-based input device. The interaction data is processed with a first machine learning process to determine a set of 5 characteristics for describing the subject. The set of characteristics is then processed with a second machine-learning process to generate a classification result for the subject. An instruction is provided to the subject for directing the subject to interact with the movement-based input device, wherein the instruction defines a challenge comprising a time-varying parameter.

Abstract: A system and method of detecting a sobriety of a subject utilizing a mobile device. The mobile device includes a processor and a memory storing historical data including movements indicating a drunk state, movements indicating a sober state, or a combination of both. The mobile device further includes a user interface, a recorder operable to capture a recording, and an accelerometer operable to generate acceleration values of movements of the recording. When the mobile device captures the recording of a subject performing movements, the processor compares the data on the memory with the acceleration values of the movements of the subject and produces an indication of either a drunk state of the subject or a sober state of the subject on the user interface.

Abstract: Disclosed herein is a non-invasive system for determining tissue composition. The system comprises an imaging system with a non-invasive probe, a signal analyzer, and a correlation processor. The probe includes active imaging components for emitting energy and collecting imaging data including reflected signals from an object of interest. The signal analyzer analyzes the imaging data and determines one or more signal properties from the reflected signals. The correlation processor then associates the one or more signal properties to pre-determined tissue signal properties of different tissue components through a pattern recognition technique wherein the pre-determined tissue signal properties are embodied in a database, and identifies a tissue component of the object based on the pattern recognition technique.

Abstract: An intraoral multisensor device includes a mouthpiece, a plurality of sensors at least one of attached to or integrated with the mouthpiece, and a data communications unit configured to receive signals from the plurality of sensors. The mouthpiece has a form to permit stable arrangement at least partially within a person's mouth such that it can remain for hands-free sensing of a plurality of biological parameters. Also, an intraoral multisensor system includes an intraoral multisensor device and a data processing device adapted to communicate with the intraoral multisensor device.

Abstract: A wearable cognitive function evaluation assisting device includes a wearable garment, a near infrared (NIR) light source, an image capturing unit, a storage unit, a projection unit, a sound-recording unit, a processing unit, a transceiver, a control unit, and a power supply unit. The image capturing unit can be selectively extracted from the wearable garment for capturing a continuous image of an oxygenated heme (HbO2) where the NIR light source is irradiated. The projection unit can be selectively extracted from the wearable garment for projecting one of the cognitive environment images stored in the storage unit. The processing unit converts the question and answer recorded by sound-recording unit into a question and answer audio signal. The transceiver receives the continuous image of HbO2 and the question and answer audio signal and then transmits them out.

Abstract: Described herein are functionalized garments that can be worn on the torso of a subject and can be configured with varying zones or areas of compressions and can provide increased signal-to-noise ratios and reduced motion artifacts in areas while allowing a substantially unimpeded freedom of motion.

Abstract: Non-invasive tracking methods and devices are provided that are configured to track at least one selectable internal element within a patient, such as a vertebra, relative to an external point outside of the patient's body, such as a reference point within an operating room. For example, in one embodiment, a patch is provided and is configured to be removably attached to skin of a patient, and to track a distance relative to the patch of at least one selectable element within a patient. The patch can also be configured to be tracked by an external monitoring system that tracks its orientation and location relative to the monitoring system, thereby indicating a position of a vertebra.