Abstract: The present invention relates to methods of detecting novel mutations in a PKD1 and/or PKD2 gene that have been determined to be associated with autosomal dominant polycystic kidney disease (ADPKD) in order to detect or predict the occurrence of ADPKD in an individual.

Abstract: A method is described for using ROR gamma t or ROR alpha to diagnose acne and/or to screen inhibitors of Th17 differentiation. Specifically described, are methods of inhibiting ROR gamma t or ROR alpha and use of the screened inhibitors in acne treatment.

Abstract: Enolase levels are predictive of the probability that a cancer patient will respond favorably to cancer therapy involving administration of hypoxia-activated achiral phosphoramide mustards.

Abstract: Disclosed are methods of, and assay and kits for, detecting and diagnosing arterial plaque rupture using the expression of miR-222, mi-221 and circ284. Also disclosed are methods of treating arterial plaque rupture and methods of identifying agents for use thin the treatment of arterial plaque rupture.

Abstract: The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid relapse, of his cancer. It is based, at least in part, on the results of a comprehensive genome analysis on 241 prostate cancer samples (104 prostate cancer, 85 matched bloods, 49 matched benign prostate tissues adjacent to cancer, and 3 cell lines) which indicate that (i) genome copy number variation (CNV) occurred in both cancer and non-cancer tissues, and (ii) CNV predicts prostate cancer progression.

Abstract: There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions. Identified biomarkers can be used to determine and/or monitor the disease state for a subject with an associated lymphoid disorder or autoimmune disease or other condition. In particular, the invention provides a sensitive method for monitoring lymphoid neoplasms that undergo clonal evolutions without the need to development alternative assays for the evolved or mutated clones serving as patient-specific biomarkers.

Abstract: A method for detecting genes sensitive to high-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to high-level ionizing radiation discovered in a carcinogenic entity and verified in a normal entity are detected, by subjecting a cancerous AKR/J mouse and a normal ICR mouse to high-level radiation. Thymus is collected therefrom and fatty acid metabolism-related genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, the present invention allows a gene having a specific reaction to radiation to be accurately detected by preventing the interference of confounding variables.

Abstract: The present invention relates to methods for predicting pancreatic cancer treatment response.

Abstract: Methods for the rapid detection of the presence or absence of Babesia in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting Babesia and kits are provided that are designed for the detection of Babesia, including, but not limited to, the Babesia species of B. microti, B. divergens, B. duncani, and B. venatorum. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of Babesia.

Abstract: A method comprising: (a) providing a partially processed sucrose crop product containing at least 2% optionally at least 5% of the sucrose content of said crop at harvest on a dry solids basis, cellulose and lignin; (b) hydrolyzing said partially processed crop product with HCl to produce an acid hydrolyzate stream and a lignin stream; and (c) de-acidifying said hydrolyzate stream to produce a de-acidified sugar solution and an HCl recovery stream. Additional, methods, systems and sugar mixtures are also disclosed.

Abstract: In a hot isostatic pressing (HIP) method, the component to be treated, affected by imperfections, like porosity, cracks and cavities in its structure, is placed into a container together with non-metallic material in form of powder or grains having size greater than the porosity and the cracks and imperfections of the component. During the HIP process, the non-metallic material presses on the whole surface of the embedded component in order to generate a combination of temperature and forces capable to reduce defects, embedded and not embedded, in the component itself. The component is not contaminated during the process thus allowing easily removal of the non-metallic material by a simple operation of mechanical cleaning or chemical washing.

Abstract: An oriented electrical steel sheet includes Ba at about 0.005 wt % to about 0.5 wt % inclusive, Y at about 0.005 wt % to about 0.5 wt % inclusive, or a composite of Ba and Y at about 0.005 wt % to about 0.5 wt % inclusive, the remainder including Fe and impurities, based on 100 wt % of a total composition of a base steel sheet thereof.

Abstract: Provided are a high-strength steel sheet and a method for manufacturing the steel sheet. The high-strength steel sheet has a specified chemical composition with the balance being Fe and inevitable impurities, a microstructure including, in terms of area ratio, 30% or more of a ferrite phase, 40% to 65% of a bainite phase and/or a martensite phase, and 5% or less of cementite, in which, in a surface layer that is a region within 50 ?m from the surface in the thickness direction, the area ratio of a ferrite phase is 40% to 55% and the total area ratio of a bainite phase having a grain diameter of more than 5 ?m and/or a martensite phase having a grain diameter of more than 5 ?m is 20% or less, and a tensile strength is 980 MPa or more.

Abstract: A high-silicon steel sheet is excellent in terms of punching workability and magnetic property. The high-silicon steel sheet has a chemical composition containing, by mass %, C: 0.02% or less, P: 0.02% or less, Si: 4.5% or more and 7.0% or less, Mn: 0.01% or more and 1.0% or less, Al: 1.0% or less, O: 0.01% or less, N: 0.01% or less, and the balance being Fe and inevitable impurities, a grain-boundary oxygen concentration (oxygen concentration with respect to chemical elements segregated at grain boundaries) of 30 at % or less, and a microstructure in which a degree of integration P(211) of a {211}-plane of ?-Fe on a surface of the steel sheet is 15% or more P(211)=p(211)/S×100(%), wherein S=p(110)/100+p(200)/14.93+p(211)/25.88+p(310)/7.68+p(222)/1.59+p(321)/6.27+p(411)/1.55, and p(hkl): integrated intensity of a peak of X-ray diffraction of an {hkl}-plane.

Abstract: A method for manufacturing a metal sheet comprising pinching the metal sheet in rapid quenching between a pair of pinch rolls in the range where the temperature of the metal sheet is from (TMs+150) (° C.) to (TMf?150) (° C.), wherein the Ms temperature of the metal sheet is TMs (° C.) and the Mf temperature thereof is TMf (° C.), as well as a rapid quenching unit comprising a pair of pinch rolls capable of use in such a method.

Abstract: An apparatus and method for treatment of articles, using glass failure generated pulses. The apparatus and method is directed towards the hardening and compaction of a glass-covered elongated object that is impacted by a flyer plate having a shape that is complimentary to that of the elongated object. The flyer plate is propelled by, an explosive reaction to create the impact on the glass-covered elongated object. This results in an explosive reaction that pressure-treats the elongated object, thereby causing the hardening and compaction.

Abstract: A copper alloy for fastening wherein the alloy has a structure of a mixture of ?-phase and a ?-phase; and wherein the alloy has a composition represented by the general formula: Cubal.ZnaMnb, where bal., a, and b are expressed in % by mass, bal. represents the balance, 34?a?40.5, 0.1?b?6, and inevitable impurities may be contained; and the composition satisfying the equation (1): b?(?8a+300)/7, where 34?a<37.5 and equation (2): b?(?5.5a+225.25)/5, where 35.5?a?40.5.

Abstract: The disclose relates to ordered Alloy 690 comprising: a matrix that includes a short range order (SRO) in a state in which nickel (Ni) is enriched, and chromium (Cr) and iron (Fe) are depleted, and the ordered Alloy 690 is characterized by having excellent resistance to stress corrosion cracking and improved thermal conductivity due to agglomeration of nickel (Ni) atoms, as compared with the unordered Alloy 690.

Abstract: Described herein are additive manufacturing methods and products made using such methods. The alloy compositions described herein are specifically selected for the additive manufacturing methods and provide products that exhibit superior mechanical properties as compared to their cast counterparts. Using the compositions and methods described herein, products that do not exhibit substantial coarsening, such as at elevated temperatures, can be obtained. The products further exhibit uniform microstructures along the print axis, thus contributing to improved strength and performance. Additives also can be used in the alloys described herein.

Abstract: The invention provides a highly corrosion-resistant, high strength, Al-containing weathering steel plate, wherein the chemical composition comprises in weight percentages (wt %) of: C: 0.02-0.07%, Si: 0.2-1.0%, Mn: 0.2-2.2%, P?0.01%, S?0.006%, Cu: 0.2-0.5%, Cr: 0.5-3.5%, Ni: 0.2-1.2%, Al: 0.4-4.0%, N?0.005%; selectively added one or more of Nb: 0.01-0.06%, Ti: 0.01-0.10%, V: 0.02-0.10%; the balance of Fe and unavoidable impurities, wherein Al/Cr is 0.5-8.0. The steel plate has a yield strength of 350-500 MPa, an elongation of 20% or more, a relative corrosion rate of 27% or less and a good impact toughness and a low yield ratio. The present application also provides a method for manufacturing the weathering steel plate.

Abstract: A martensitic alloy component includes by weight, 0.25% to 0.31% carbon (C), 2.1% to 3.0% manganese (Mn), 0.22% to 0.28% silicon (Si), 2.0% to 2.2% chromium (Cr), 0.45% to 0.55% molybdenum (Mo), 0.08% to 0.12% vanadium (V), and the balance is iron (Fe) and incidental impurities. The manganese-chromium martensitic alloy component has a hardenability corresponding to an ideal diameter of about 15 inches to about 30 inches or more.

Abstract: A castable, moldable, and/or extrudable structure using a metallic primary alloy. One or more additives are added to the metallic primary alloy so that in situ galvanically-active reinforcement particles are formed in the melt or on cooling from the melt. The composite contain an optimal composition and morphology to achieve a specific galvanic corrosion rate in the entire composite. The in situ formed galvanically-active particles can be used to enhance mechanical properties of the composite, such as ductility and/or tensile strength. The final casting can also be enhanced by heat treatment, as well as deformation processing such as extrusion, forging, or rolling, to further improve the strength of the final composite over the as-cast material.

Abstract: Provided is an ?+? titanium alloy hot-rolled sheet consisting of, in mass %, Al: 4.7 to 5.5%, Fe: 0.5 to 1.4%, N: less than or equal to 0.03%, Si: 0.15 to 0.40%, a ratio of Si/O: 0.80 to 2.80, [O]eq in Expression (1): more than or equal to 0.13% and less than 0.25%, and the balance: Ti and impurities. In a case where an ND direction represents a normal direction of the hot-rolled sheet, a TD direction represents a sheet-width direction of the hot-rolled sheet, a c-axis orientation represents a normal direction of a (0001) plane in an ? phase, XND represents a strongest intensity among X-ray (0002) reflection relative intensities of crystal grains in which the c-axis orientation is in a range of 30° from the ND direction, and XTD represents a strongest intensity among intensities in which the c-axis orientation is in a range of ±10 degrees in the TD direction, XTD/XND is more than or equal to 4.

Abstract: The manufacture of a metal turbomachine part, comprising steps consisting of melting a titanium-aluminium intermetallic compound by plasma torch in a ring mould, extracting therefrom an ingot, as cast, in a state cooled from molten, cutting the ingot into at least one blank with an external shape that is simpler than the more complex one of said part to be manufactured, and machining the blank in order to obtain the part with said more complex external shape.

Abstract: Provided is (i) a hot-dip Al-based alloy-coated steel sheet which includes a coated layer having a surface on which fine spangles are stably and sufficiently formed and which has a beautiful surface appearance due to the fine spangles thus formed on the surface of the coated layer, and (ii) a method of producing such a hot-dip Al-based alloy-coated steel sheet. The hot-dip Al-based alloy-coated steel sheet includes: a substrate steel sheet; and a hot-dip aluminum-based alloy coated layer which is formed on a surface of the substrate steel sheet and which contains boron at an average concentration of not less than 0.005 mass % and contains potassium at an average concentration of not less than 0.0004 mass %.

Abstract: To provide a vapor deposition source of which material usage efficiency is higher as compared with the related art. A vapor deposition source (10) includes a vapor deposition particles ejecting unit (30) configured to include multistage of nozzle units layered apart from each other in a vertical direction, each of the nozzle units including at least one vapor deposition nozzle (32, 52), and at least one space part (43) provided between the multistage of vapor deposition nozzles, and a vacuum exhaust unit (14) connected with the at least one space part (43).

Abstract: A method of forming a high strength copper alloy. The method comprises heating a copper material including from about 2 wt. % to about 20 wt. % manganese by weight of the copper material to a temperature above 400° C., allowing the copper material to cool to a temperature from about 325° C. to about 350° C. to form a cooled copper material, and extruding the cooled copper material with equal channel angular extrusion to form a cooled copper manganese alloy.

Abstract: Disclosed herein is a transparent glass system that includes an optical grade silicon substrate, and a nanocrystalline diamond film on the silicon substrate, the diamond film deposited using a chemical vapor deposition system having a reactor in which methane, hydrogen and argon source gases are added. Further disclosed is a method of fabricating transparent glass that includes the steps of seeding an optical grade silicon substrate and forming a nanocrystalline diamond film on the silicon substrate using a chemical vapor deposition system having a reactor in which methane, hydrogen and argon source gases are added.

Abstract: Forming a protective coating ex situ in an atomic layer deposition process to coat one or more chamber components subsequently installed in a reaction chamber provides a number of benefits over more conventional coating methods such as in situ deposition of an undercoat. In certain cases the protective coating may have a particular composition such as aluminum oxide, aluminum fluoride, aluminum nitride, yttrium oxide, and/or yttrium fluoride. The protective coating may help reduce contamination on wafers processed using the coated chamber component. Further, the protective coating may act to stabilize the processing conditions within the reaction chamber, thereby achieving very stable/uniform processing results over the course of processing many batches of wafers, and minimizing radical loss. Also described are a number of techniques that may be used to restore the protective coating after the coated chamber component is used to process semiconductor wafers.

Abstract: Methods for depositing a yttrium-containing film through an atomic layer deposition process are described. Some embodiments of the disclosure utilize a plasma-enhanced atomic layer deposition process. Also described is an apparatus for performing the atomic layer deposition of the yttrium containing films.

Abstract: A showerhead tilt adjustment mechanism is provided which supports a showerhead module in a top plate of a semiconductor substrate processing apparatus, the showerhead tilt adjustment mechanism including a differential screw which provides coarse and fine adjustments to adjust gap/tilt/planarization of a faceplate of the showerhead module with respect to an upper surface of a substrate pedestal module adjacent the faceplate in the semiconductor substrate processing apparatus.

Abstract: Embodiments of the present invention provide a liner assembly including an inject insert. The inject insert enables tenability of flow parameters, such as velocity, density, direction and spatial location, across a substrate being processed. The processing gas across the substrate being processed may be specially tailored for individual processes with a liner assembly according to embodiment of the present invention.

Abstract: Aqueous dispersions of artificially synthesized, mussel-inspired polydopamine nanoparticles were inkjet printed on flexible polyethylene terephthalate (PET) substrates. Narrow line patterns (4 ?m in width) of polydopamine resulted due to evaporatively driven transport (coffee ring effect). The printed patterns were metallized via a site-selective Cu electroless plating process at a controlled temperature (30° C.) for varied bath times. The lowest electrical resistivity value of the plated Cu lines was about 6 times greater than the bulk resistivity of Cu. This process presents an industrially viable way to fabricate Cu conductive fine patterns for flexible electronics at low temperature, and low cost.

Abstract: Disclosed is a method of fabricating an aluminum alloy member for bonding different materials. The method may include etching the aluminum alloy member with one or more etching solutions, and forming one or more undercuts on a surface of the aluminum alloy member.

Abstract: A method includes providing a workpiece with at least one surface having an anodized aluminum coating and a trivalent chromium sealant. The at least one surface of the workpiece is submerged in a post-treatment sealant solution for 0.5 to 20 minutes. The sealant composition consists essentially of a corrosion inhibitor formulation, a water soluble polymer, an organic complexing agent, and an oxidant. The corrosion inhibitor formulation is formulated from at least one anodic corrosion inhibitor compound, at least one cathodic corrosion inhibitor compound, or a combination thereof. A concentration of each of the corrosion inhibitor formulation, the water soluble polymer, the organic complexing agent, and the oxidant is each in a range of 1-50 mM.

Abstract: A cathodic protection system that is able to monitor the operational status of a plurality of test points and rectifiers. The cathodic protection system includes a plurality of test point monitors that are associated with test points and a plurality of rectifier controllers that are associated with the rectifiers located along a utility pipeline. The test point monitors are battery powered while the rectifier controllers may be utility line powered. Each of the test point monitors and rectifier controllers communicates with a base station utilizing a wireless communication technique. The base station communicates with a back end server that operates to accumulate data and visually present the data to an operator on a display associated with cathodic protection software application. The software application allows the operator to monitor the health of the system and address alerts generated by any of the test points or monitored rectifiers.

Abstract: A sacrificial electrode attachment structure includes: a first pipe in which electrolyte flows; a second pipe which is formed of an insulating material and allows the electrolyte to flow; a cylindrical sacrificial electrode unit arranged between the first pipe and the second pipe so as to allow the electrolyte to flow, and including a sacrificial electrode that contacts the electrolyte; a first pipe joint adapted to liquid-tightly connect the first pipe to the sacrificial electrode unit in a detachable manner; and a second pipe joint adapted to liquid-tightly connect the second pipe to the sacrificial electrode unit in a detachable manner.

Abstract: An electrolytic cell includes a housing, a first diaphragm, a first electrode, a second electrode, and a first discharge port. The housing held an electrolyte solution. The first diaphragm partitions the interior of the housing into a first cell and a second cell. The first electrode is provided inside the first cell. The first electrode includes a first surface facing the first diaphragm, a second surface different from the first surface, and a first hole. The second electrode is provided inside the second cell adjacent to the first diaphragm. The second electrode includes a third surface adjacent to the first diaphragm, a fourth surface different from the third surface, and a second hole. The first discharge port discharges the electrolyte solution from the second cell. The first cell is configured to supply the electrolyte solution supplied therein to the third surface side of the second cell.

Abstract: The present invention is directed to composite nanoparticles comprising a metal, a rare earth element, and, optionally, a complexing ligand. The invention is also directed to composite nanoparticles having a core-shell structure and to processes for preparation of composite nanoparticles of the invention.

Abstract: A method for the substantially complete conversion of hydrogenous matter to higher value product, the method comprising: (i) subjecting the hydrogenous matter to a substantially complete deconstruction process in which an aqueous phase containing a multiplicity of deconstructed compounds is produced; and (ii) contacting the aqueous phase with an anode of a microbial electrolysis cell, the anode containing a community of microbes thereon which oxidatively degrade one or more of the oxygenated organic compounds in the aqueous phase to produce protons and free electrons at the anode, wherein the protons and free electrons are transported to the cathode to produce hydrogen gas or a valuable reduced organic compound at the cathode upon application of a suitable cell potential across the anode and cathode. The invention is also directed to an apparatus for practicing the method described above.

Abstract: The present disclosure relates to electrolysis. For example, an electrolysis system for carbon dioxide utilization may include: an electrolysis cell having an anode and a cathode, where carbon dioxide reduces at the cathode to at least one hydrocarbon compound or to carbon monoxide; first and second electrolyte reservoirs; a first product gas line from the first electrolyte reservoir; a second product gas line from the second electrolyte reservoir; a first connecting line supplying electrolyte from the first electrolyte reservoir to the anode; a second connecting line taking electrolyte from the anode to the second electrolyte reservoir; a third connecting line supplying electrolyte from the second electrolyte reservoir to the cathode; a fourth connecting line taking electrolyte from the cathode off to the first electrolyte reservoir; and a pressure-equalizing connection directly connecting the first and second electrolyte reservoirs.

Abstract: The present invention relates to an oxygen generator integrated with an ozone removal filter such that an ozone removal filter is provided in an oxygen discharge opening communicating with an oxygen discharge hole of a water electrolytic cell constituting an apparatus for producing oxygen by using mineral water among generally used water, for filtering ozone generated with oxygen during electrolysis of water and ozone compounds, in which ozone is combined with various organic and inorganic materials contained in mineral water, such as calcium (Ca), magnesium (Mg) and silicon (Si), and thus the oxygen generator allows only high purity oxygen to pass through and to be discharged through the oxygen discharge hole.

Abstract: In a film forming method, in a state where a metal solution is sealed in a first accommodation chamber of a housing with a solid electrolyte membrane and a fluid is sealed in a second accommodation chamber of a placing table with a thin film, a substrate is placed on the placing table and the placing table and the housing are moved relative to each other to cause the substrate to be interposed between the solid electrolyte membrane and the thin film, the solid electrolyte membrane and the thin film are pressed against the substrate interposed therebetween to cause the solid electrolyte membrane and the thin film to conform to a surface and a rear surface of the substrate, thereby forming a metal film.

Abstract: Method and plant for continuous chrome plating of metal bars, tubular elements and similar, wherein the bar to be chromed is made move forward fastly in a device of chrome plating without of tank of chrome plating including a plurality of anodic cells of chrome plating with tubular-torx shape, into which an electrolytic solution flows with high density of current, for forming on the bar a multi-layer chromium plating while the bar moves forward through the anodes-cells themselves, and wherein the device is characterized in feeding the electrolytic solution with a flow axially distributed and with a circulation of the electrolyte in a turbulent flow, controlled through the anode of chrome plating, said plant including furthermore many cooling stations of the bar by a jet of liquid with cryoscopic thermal step, the sealing of the bath is guaranteed by gaskets in plastic material which are reinforced by armonic steel springs.

Abstract: The present invention relates to a leveling agent and electroplating composition comprising the same. When features are plated using the electroplating composition of the present invention, excellently leveled plated surfaces with minimized defects may be obtained.

Abstract: Anodic films that have a white color, and methods for forming the same, are described. According to some embodiments, the anodic films have multiple metal oxide layers. A first layer can provide scratch and chemical resistance and a second layer can provide a light diffusing pore structure that diffusely reflects incoming light and provides a white appearance to the anodic film. According to some embodiments, the anodic films also include a smoothed barrier layer that specularly reflects incoming light so as to brighten the appearance and enhance the white color of the anodic film. The resulting anodic films have an opaque white appearance not achievable using conventional techniques. The anodic films are well suited for providing cosmetically appealing coatings for consumer products, such as housings for electronic products.

Abstract: Sealed anodic coatings that are resistant to leaching of nickel and nickel-containing products and methods for forming the same are described. Methods involve post-sealing thermal processes to remove at least some of the leachable nickel from the sealed anodic coatings. In some embodiments, the post-sealing thermal processes involve immersing the sealed anodic coating within a heated solution so as to promote diffusion of the leachable nickel out of the sealed anodic coatings and into the heated solution. The resultant sealed anodic coating is pre-leached of nickel and is therefore well suited for many consumer product applications. In some embodiments, a post-sealing thermal process is used to further hydrate and seal the sealed anodic coating, thereby repairing structural defects within the sealed anodic coating.

Abstract: A plating method for plating a substrate by increasing a current value from a predetermined current value to a first current value is provided. The plating method plates the substrate for a first predetermined period with the first current value when a first current density corresponding to the first current value is lower than a limiting current density. This plating method includes measuring a voltage value applied to the substrate, and when the current value is increased from the predetermined current value to the first current value, determining whether the first current density is equal to or more than the limiting current density or not based on an amount of change in the voltage value.

Abstract: Electroplating results can be improved by dynamically controlling the pressure in different parts of an electroplating apparatus. For example, a number of plating problems can be avoided by ensuring that the pressure in an anode chamber always remains slightly above the pressure in an ionically resistive element manifold, both during electroplating and during non-electroplating operations. This pressure differential prevents the membrane from stretching downward into the anode chamber.

Abstract: A process for directional solidification of a cast part comprises energizing a primary inductive coil coupled to a chamber having a mold containing a material; energizing a primary inductive coil within the chamber to heat the mold via radiation from a susceptor, wherein the resultant electromagnetic field partially leaks through the susceptor coupled to the chamber between the primary inductive coil and the mold; determining a magnetic flux profile of the electromagnetic field; sensing a magnetic flux leakage past the susceptor within the chamber; generating a control field from a secondary compensation coil coupled to the chamber, wherein the control field controls the magnetic flux experienced by the cast part; and casting the material within the mold under the controlled degree of flux leakage.