Abstract: An inflatable device for turning or positioning a person in a bed. The inflatable device includes an inflatable body formed by a top sheet and a bottom sheet disposed beneath the top sheet to define a cavity configured to be inflated such that the top sheet forms a top wall of the cavity and the bottom sheet forms a bottom wall of the cavity. The device further includes at least one port having a port opening in fluid communication with the cavity and configured to provide an air input for air for inflating the cavity, wherein the at least one port comprises an elastic member for adjusting a size of the port opening.

Abstract: According to the present disclosure, a microclimate system includes a support surface, an air box, and an immersion sensor. The support surface is configured to support a patient and conduct air along a surface of the support surface so that heat and moisture from a patient lying on the support surface are drawn away from the surface. The air box includes a blower coupled to the support surface to provide airflow to the support surface. The immersion sensor is configured to detect the immersion of the patient into the support surface.

Abstract: An article (1; 100) for collecting urine (300) and stools (400) of a user, the article having a support surface (10A) for supporting the buttocks of the user; and a chamber (20) that communicates with an opening (10E) defined by the support surface (10A) and that presents a bottom portion (22); and a spacer (10) suitable for maintaining the bottom portion at a distance from the support surface. The article has an internal wall element (23; 123) that is situated at a position vertically intermediate between the support surface (10A) and the bottom portion (22) and that is suitable for adopting a first configuration and a second configuration. In the first configuration, the internal wall element forms an obstacle for substantially preventing stools (400) from passing to the bottom while allowing communication for urine (300). In the second configuration, the obstacle is substantially eliminated so as to allow stools to pass to the bottom of the chamber (20).

Abstract: A transport incubator includes a support structure having a base provided with at least one first guide, and a housing structure coupled with the supporting structure. The housing structure includes a first portion having at least one first side panel slidably coupled with the first guide of the base, and a second portion laterally delimited by at least one first side wall, on which the at least one first side panel of the first portion slides.

Abstract: A patient securing overlay is provided that includes a sheet of fabric for supporting a patient's torso on a surgical table. The sheet of fabric has an upper surface configured to face the patient and a lower surface configured to face a surgical table mattress or underbody support. The sheet of fabric includes friction enhancing elements applied to at least a portion of the upper surface thereof. The sheet of fabric can include an extension at a foot end of the sheet of fabric that provides material to be tucked under a foot end of the surgical table mattress or underbody support for securing the foot end of the sheet of fabric to the surgical table mattress or underbody support. The extension can include one or more friction enhancing elements.

Abstract: A spool assembly and method of use is disclosed having generally a first and a second mating portions which can mate along a longitudinal axis of the spool to retain a belt therein. The mating surfaces of the first and second mating portions can take a variety of geometries or splines which can efficiently retain the belt while maintaining a suitable transmission ratio. In an exemplary embodiment, the spool exit curve for the retained belt can be radially inward of a majority of the spool to reduce the overall diameter of the spool. In some exemplary embodiments, the spool can be mounted within a motor and rotated thereby to spool and unspool the belt.

Abstract: An apparatus and method are provided for imparting a repetitive motion to a user. The apparatus may include one or more seat platforms and one or more backrests. Repeated motion of the pelvis and shoulders of the user may be contra lateral. The motions of the user may mimic walking. The apparatus may include a chair. The apparatus may include a sensor. The sensor may be used to control the apparatus and/or the sensor may be used to adjust the movement regime according to the user. The apparatus may help for example, to mobilize limited mobility users and/or to train healthier habits.

Abstract: A wearable walking assist robot is provided that ensures high walking assistance performance without a complex calculation process by detecting a gait phase based on pressure distribution on feet and performing a corresponding control mode that is set in advance. The wearable walking assist robot includes a sensor unit that senses pressure on the soles of the feet of a wearer and a controller that determines gait phases of both a first leg to be operated and a second leg based on the sensed pressure. Additionally, the controller selects one of a plurality of control modes set in advance based on the determined gait phases and operates a joint-driving unit for the first leg to be operated.

Abstract: A foldable frame construction for mobility aids has a mounting frame, a pivotal arm, and an operating element. The mounting frame has a fixed end, a limiting end, a limiting hole formed through the mounting frame adjacent to the limiting end, and a through hole formed through the mounting frame between the fixed end and the limiting hole. The pivotal arm is rotatably connected to the mounting frame and has a positioning hole formed through the pivotal arm and selectively aligning with the through hole. The operating element is connected to the pivotal arm and the mounting frame to limit a position of the pivotal arm relative to the mounting frame, and has a fixing ring base securely connected to the pivotal arm around the positioning hole, an engaging bolt movably mounted in the fixing ring base, and a pull button connected to the engaging bolt.

Abstract: A system is disclosed which includes a walking assistance robot for assisting a smooth start of a user's action after standing up from a chair. A system according to an aspect of the present disclosure includes a walking assistance robot and an automatic elevation chair that moves a seating surface where a user sits. The automatic elevation chair detects a consciousness level of the user and transmits consciousness level information on the detected consciousness level of the user to the walking assistance robot via the network. The walking assistance robot, including a body and a rotor that moves the walking assistance robot, receives the consciousness level information via the network and controls resistance force to rotation of the rotor based on the received consciousness level information.

Abstract: A walking aid device including a moving body, a message receiving element, a positioning element, and a processor is provided. The message receiving element, the positioning element, and the processor are respectively disposed at the moving body, and the message receiving element and the positioning element are respectively electrically coupled to the processor. The message receiving element is configured to receive a message from a target, and the positioning element is configured to locate a position of the moving body. When the message from a target is received by the message receiving element, the processor determines an orientation of the target according to the message, and the positioning element locates the position of the moving body. The processor produces a position data according to the orientation of the target and the position of the moving body, and controls the moving body to move to where the target is located.

Abstract: A walker adapted for attachment to a wheelchair may be used to assist a user with walking while retaining the wheelchair in close proximity behind the user for use when the user needs to sit. The walker may be removably attached to the frame of the wheelchair for easy exchange of use from one wheelchair to another. A pivotable, removably attachable gate between two vertical rods may allow for the walker to be manipulated from a walking position to a stored position. The gate may include an extendable width to allow for use with wheelchairs of different widths. Telescopic supports may attach the walker to the wheelchair, thereby allowing the user to extend and retract the walker between the walking position and the stored position.

Abstract: There is provided a processing unit that includes a direction decision unit and a guide information generation unit. The direction decision unit determines a direction in which a person who behaves without a sense of sight walks. The guide information generation unit generates guide information for the person who behaves without the sense of sight to walk in the determined direction. The present technology is applicable, for example, to a smartphone or the like used by the person who behaves without the sense of sight.

Abstract: A therapeutic device and method for using the same. The therapeutic device has a supportive body and a pressure applicator extending from the body that is configured to apply pressure to suboccipital muscles of a patient. The pressure applicator may be altered to adjust a position and points through which to apply pressure to the suboccipital muscles. The body may be positioned at an angle relative to the patient's neck and the pressure applicator is applied to the suboccipital muscles. The pressure can be applied for a duration of time to relieve and/or prevent headaches and migraines in patients.

Abstract: A foam generator is configured such that liquid contents pumped by an internal pressure as a result of directly compressing an inverted compression receptacle, having the liquid contents stored therein, are mixed with air in a gas-liquid mixing chamber and, at the same time, directly discharged in the form of foam. That is, direct compression of the inverted compression receptacle allows the liquid contents to be instantly discharged in the form of foam, thereby further improving product responsiveness.

Abstract: A pulmonary expansion therapy (PXT) device may be a handheld device that covers specific lung fields and may generate negative pressure fields locally. The device also may provide vibratory/percussion therapy for airway clearance. The PXT may generate a localized negative pressure field non-invasively to the exterior of the chest wall, thereby increasing the functional residual capacity in underlying lung fields. As a result, increased ventilation and perfusion to the targeted internal lung field may be achieved by creating a decrease in the external barometric pressure relative to the more positive intrinsic airway pressures. The PXT device also may improve lung compliance by enabling a medical professional to grab and elevate the chest wall to compensate for the dysfunction of the respiratory musculature responsible for lifting the chest wall. In some embodiments, once a targeted functional residual capacity (FRC) has been established, vibration or percussion may be applied.

Abstract: A reduced pressure treatment system is provided that includes a canister that is fluidly connected to a tissue site and is configured to receive fluid drawn from the tissue site under the influence of a reduced pressure. A reduced pressure source provides the reduced pressure and is fluidly connected to the tissue site by a fluid communication path, which may include a source conduit, the canister, and a target conduit. A sensing device communicates with the source conduit and is configured to sense a pressure in the source conduit. A valve communicates with the source conduit and is configured to vent the reduced pressure. A processing unit communicates with the sensing device and the valve and is configured to open the valve for a selected amount of time, determine a decay of reduced pressure, and determine a fill status of the canister based on the decay of reduced pressure.

Abstract: A method for therapeutically affecting the circulation of blood in a person in combination with or with medication to treat a medical condition includes the steps of administering a composition for treating a circulatory condition, providing a source of high pressure air in fluid communication with a plurality of air pressure actuated valves, each of the valves mounted on, and in fluid communication with, an inflatable bladder disposed within a cuff removably attached about at least one of the feet, calves, thighs, buttocks of the person; providing a source of low pressure aft in fluid communication with the plurality of valves, wherein a constant pressure is exerted against said valves; and controlling inflation of the bladders in a predetermined sequence, magnitude of inflation pressure and period of time during a cardiac cycle of the person and as a function of the person's physiological reaction to said composition.

Abstract: Therapeutic roller apparatus including at least two easily interchangeable elongated, semi-cylindrical component assemblies, each formed by a rigid substrate component having a concave inner surface and a convex outer surface, and a resilient pad component affixed to and covering the outer surface of the rigid substrate part. The side edges of the component assemblies are adapted to mate together to form a cylindrical roller body having a first outer diameter. The roller body ends are provided with first latch elements. A pair of cylindrical end caps, each having an outer diameter greater than the roller's first outer diameter, and an inner diameter adapted to mate with and capture an end of the assembled roller body. The end caps include second latch elements adapted to lockingly engage the first latch elements and secure the entire assembly together. In use, all user weight applied to the roller body is transferred to the end caps.

Abstract: An oral stimulating device is inserted within a mouth of an individual and engages over the teeth. The oral stimulating device comprises a general U-shaped mouthpiece for engaging the teeth of the individual. A plurality of protruding knobs are coupled to the general U-shape mouthpiece. A vibrating device and an electric current source are within the general U-shaped mouthpiece for emitting vibration from the general U-shape mouthpiece. The plurality of protruding knobs and the emitting vibration provides oral stimulation.

Abstract: In one embodiment, the present invention includes an apparatus to heat a body. A first conductive path and/or a second conductive path include a resistive heating element that produces heat from said current. The first conductive path is coupled to redirect the current to the second conductive path and set up complementapy magnetic fields between said first and second layers. A third layer substantially blocks an electric field produced from the resistive heating element included in the first layer and/or second layer.

Abstract: The present invention relates to a negative pressure device, including: a hollow needle assembly including: a hollow needle adaptor, the hollow needle adaptor has an axial through hole, a proximal connector, a distal connector and a flange between the proximal connector and the distal connector, and at least one hollow needle, each of the at least one hollow needle has a tip and an axial through hole and is in fluid communication with the proximal connector of the hollow needle adaptor; a host machine, the host machine includes a control module and a vacuum pump; and an exhaust pipe, the exhaust pipe is in fluid communication with the host machine and the distal connector of the hollow needle adaptor.

Abstract: A decorative medication holder may reduce or eliminate medication non-adherence and work with standard and/or non-standard medication containers. The medication holder may include a body portion having an opening to a medication retaining cavity adapted for receiving a medication, such as a bottle of pills. The body portion also may be decorated with a kid-friendly aesthetic design, such as a character, animal, or the like to engage a child's interest. In some embodiments, the body portion may include a substantially flat outer surface. Alternatively, the body portion also may include three-dimensional limbs or the like which may be rigid or posable. In some embodiments, a cover may be provided to close the opening and/or secure the medication in the cavity. Alternatively, or additionally, the cavity may include textured lining or the like to grip the medication in the cavity. Other embodiments also are described.

Abstract: An adapter for a jar for use with a planetary mixer, the adapter securing a dispensing container having a body and a removable cap, the adapter having a central aperture through which a longitudinal axis of the jar passes when the adapter is inside the jar. When the dispensing container is secured to the adapter and the adapter is inside the jar: (i) the adapter maintains the container spaced from an inner wall and from a bottom of the jar; (ii) a gap is provided between a top of the jar and the container; (iii) a point on the cap of the container extends further from the bottom of the jar than does a point on the body of the container; (iv) the body of the container crosses the longitudinal axis of the jar; and (v) the container extends over more than half the diameter of the jar.

Abstract: Presented herein are embodiments of septum holders for use in syringe connectors that are used to connect syringes to other elements of liquid transfer apparatuses. The septum holders comprise a septum holder body, at least one resilient elongated arm that terminates with a distal enlarged element attached to the sides of the body, and a septum. The septum holders of the invention are characterized in that they comprise at least one bore that is created in the septum or in an insert fixed in either the body of the septum holder or in the septum that functions as the seat of a needle valve and in that the septum is attached to the bottom of the body of the septum holder projecting downwards parallel to the at least one elongated arm.

Abstract: The present disclosure relates to a medication delivery system including a medication administration device, a medication within the medication administration device, a container defining a cavity receiving the medication administration device, and a cap attached to the container and sealing the medication administration device within the cavity. The medication administration device includes an actuator extending from a body and operable to expel the medication by depressing the actuator into the body. The cap includes hold down members positioned to bear against the body of the medication administration device to prevent movement of the medication administration device toward the cap beyond a predetermined distance. The medication administration device is thereby prevented, inter alia, from prematurely discharging the medication during storage and transport.

Abstract: A hydrogen-generating substance that reacts with moisture (liquid water or water vapor) in a medical substance or moisture in air introduced into a medical container is kneaded into an exterior sheet 40 of the medical container that encloses the medical substance therein. The medical container can be a bag-shaped medical container, a tube-shaped medical container, a medical container with a sealing fastener or the like. The medical substance containing moisture can be blood, an injection solution, a drug solution, a nutrient solution, a replenishment solution (an infusion solution), an instillation solution or the like. A solid preparation is preferably enclosed within the medical container with the sealing fastener. For example, the hydrogen-generating substance to be kneaded can be metal magnesium and is preferably fine-powdered ceramics obtained by firing the mixture of a hydrogen-generating substance and a mineral substance such as calcium.

Abstract: Dual vial adapter assemblage for use with a drug vial and a liquid vial and including a vented drug vial adapter and a vented liquid vial adapter such that simultaneous venting of the liquid vial and the drug vial assists gravitational flow of liquid contents from the liquid vial into the drug vial for forming liquid drug therein.

Abstract: An intelligent pillbox with volume detection includes an open-close structure, a first structure, an air pressure sensing module and a processor. The first structure is movably configured on the open-close structure, and moves in and out of the containing space of the open-close structure to generate a constant volume difference. The air pressure sensing module is configured in the containing space for measuring the multiple air pressure values in the airtight space. The intelligent pillbox with volume detection calculates the medicine volume by the constant volume differences and the air pressure change when the patient takes out the medicine from the medicine box. It not only can avoid the patient taking wrong medicine, but also can detect the number of remaining medicine and remind the patient to replenish the medicine in the medicine box.

Abstract: A baby bottle holder for supporting a baby bottle in a manner that allows a baby to feed from a baby bottle. A substantially planar support frame has a bottom portion, a top portion with a rounded first side and a rounded second side with an opening configured to accept a portion of a baby bottle. A first side portion of the support frame is spaced apart from a second side portion, so that a baby can grasp one or both side portions. A bottle gripping element lines the opening. In one example, the bottle gripping element is a thin layer of rubbery material. In another example, the bottle gripping element includes a compliant seal portion adapted to accepting bottles of various diameters. In various examples, the frame includes rattles, movable elements such as rotatable wheels, or decorative elements such as “ears”.

Abstract: A permeable layer associated relative to a phase change material associated relative to a securing fabric layer. The permeable layer retains a therapeutic or cosmetic agent to be transferred, in whole or in part, to the user's skin. The phase change material may be dissolved within a thermoplastic matrix or situated within a suitable container. This invention provides the novelty of a phase change material, coupled with a permeable layer and a fabric layer, which work in conjunction with a therapeutic or cosmetic agent.

Abstract: The present invention relates to a sprayable composition for providing a translucent, transparent, semi-transparent or opaque sprayable hair product which exhibits a high level of hold and rigidity to hair such that hair can be held in a particular position for prolonged periods of time without unnatural hardness, superior retention of shape in conditions of heat and humidity, and imparting thickness and body compared to current hairsprays; the composition comprising: a propellant and at least one binder, wherein at least one binder comprises an ethylene vinyl alkanoate copolymer with a weight percent of vinyl alkanoate in the copolymer within the range of 19 wt % to 42 wt %.

Abstract: The present invention is directed to an oral composition having an improved ability to incorporate fluoride ions into tooth enamel and an enhanced remineralization effect.

Abstract: An oral care composition containing a gel phase, potassium nitrate, a peroxide source, an abrasive, and a fluoride source. Phase separation is not visually perceptible in the oral care composition.

Abstract: The disclosure relates to an aqueous cosmetic composition that includes at least one effect pigment is present up to about 0.02 wt %, an emulsion of at least one oil and at least one surfactant, and at least one active selected to provide one or more benefits, including, but not limited to brightening/whitening, improvement of skin tone, blemish control or reduction, reduction of redness, anti-aging, and hydration, in an aqueous solvent. The composition may include a thickener and a preservative. Methods include forming the composition and applying the composition to the skin to provide an instant “glowing” or “brightening” effect.

Abstract: Dye composition comprising 12-hydroxystearic acid, an organic amine and a dye The invention relates to a dye composition comprising 12-hydroxystearic acid, one or more organic amines and one or more dyes chosen from oxidation dyes and direct dyes. The invention also relates to a dyeing process using said dye composition.

Abstract: A lotion emulsion composition comprising a preservative enhancing agent and a rheology modifier, wherein the preservative enhancing agent comprises one of sorbitan caprylate, glyceryl caprylate/caprate, or a combination thereof, the rheology modifier comprises a hydrocolloid, the pH of the lotion emulsion composition is less than about 4.2, and the combined amount of preservative enhancing agent and rheology modifier is less than about 0.3% by weight of the total lotion emulsion composition.

Abstract: Compositions containing one or more alkyl lactate sulfate (A) of the general formula (I), R1(OCOCH(CH3))nOSO3M1??(I) in which the radical R1 is a linear or branched alkyl or alkenyl radical having 6 to 30 carbon atoms, the index n is a number in the range from 1 to 5, and the radical M1 is selected from H, Li, Na, K, Ca/2, Mg/2, ammonium, and alkanolamine, one or more compound (B) selected from phosphoric acid and the mono-, di- and tri-salts thereof, wherein the cation of these salts is selected from Li, Na, K, Ca, Mg, ammonium, and alkanolamine, one or more compound (C) selected from citric acid and the mono-, di- and tri-salts thereof, wherein the cation of these salts is selected from Li, Na, K, Ca, Mg, ammonium, and alkanolamine, and water where the following provisos apply: the weight ratio of the sum total of the compounds (B) and (C) to the sum total of the compound (A) is in the range from 1:5 to 1:10.

Abstract: The present invention relates to the use of one or more particular pyridinium salts for the treatment of keratin substances, particularly human keratin fibres such as hair. The invention also relates to a method for the treatment of keratin substances using said salts and optionally one or more chemical oxidizing agents. The invention also relates to a composition for lightening keratin substances comprising one or more pyridinium salts as defined hereinafter and one or more chemical oxidizing agents. The present invention also relates to one or more particular pyridinium salts and also to compositions containing them, especially compositions comprising a physiologically acceptable medium.

Abstract: Described herein are methods and compositions that contain a soluble polyglucosamine or polyglucosamine derivative for use in oral health. The compositions are useful for, e.g., reducing bacteria (e.g., by clumping and removing) or disrupting a biofilm in the mouth of a subject, reducing dry mouth, and reducing oral inflammation.

Abstract: Disclosed herein is a personal care conditioning and/or styling composition for keratin substrate comprising: (A) at least one conditioning and/or styling copolymer obtained from polymerizing: (i) about 0.1 wt. % to 99.9 wt. % of at least one cationic or pseudo-cationic monomer selected from the group consisting of acrylamidopropyl trimethylammonium chloride (APT AC) and/or diallyl dimethyl ammonium chloride (DADMAC); and (ii) about 0.1 wt. % to 99.9 wt. % of at least one monomer comprising at least one functionalized or unfunctionalized acryloyl moiety and at least one lactam moiety; (B) at least one cosmetically acceptable excipient; and (C) optionally, at least one effective amount of personal care active ingredient. Also disclose is a process for preparing such composition and method of use thereof.

Abstract: Disclosed is a hair conditioning composition comprising: a cationic surfactant; a high melting point fatty compound; a preformed emulsion and/or an ionic benefit agent, wherein the ionic benefit agents are those excluding ionic dyes, precursors thereof, and anionic surfactants; an alkyl ether and/or alkyl ester, preferably alkyl ether, of at least one of the following: polyethylene glycol, polypropylene glycol, polyglycerin, and mixtures thereof, and wherein the alkyl ether and/or alkyl ester has from about 50 to about 300 units of ethylene glycol, propylene glycol, glycerin and mixtures thereof; and an aqueous carrier. The composition of the present invention provides benefits from ionic benefit agents and/or preformed emulsions, while maintaining stability and wet conditioning of the composition.

Abstract: A silicone resin represented by formula (1) and having a Mw of 1,000-8,000 is useful in cosmetics. [(C6H5)3SiO1/2]a[R13SiO1/2]b[R22SiO2/2]c[R3SiO3/2]d[SiO4/2]e??(1) R1 is a C1-C8 alkyl group, C6-C12 aryl group (exclusive of phenyl) or C1-C8 fluorinated alkyl group, R2 and R3 are each independently a C1-C8 alkyl group, C6-C12 aryl group or C1-C8 fluorinated alkyl group, a=0-0.2, b=0.1-0.5, c=0-0.2, d=0.01-0.5, e=0-0.6, a+b+c+d+e=1.0, at least one phenyl group is included in the molecule. A film of the silicone resin has a refractive index of at least 1.48.

Abstract: An organic liquid soap composition; and a foam producing soap product comprising: a) a foamable organic liquid soap composition comprising the anti-microbial active ingredients of: organic shea butter; organic spearmint oil; USDA approved lime oil; organic thyme oil; and organic rosemary extract; and, b) a foam soap dispenser for dispensing the organic liquid soap composition as a premeasured amount of foaming soap, wherein the foam dispenser comprises: a recyclable plastic; a bottom front tab comprising a green color and a label indicating the composition is an organic soap. The organic soap composition may further comprise: glycerin; saponified organic coconut oil; organic olive oil; organic sunflower oil; organic jojoba oil; and organic aloe vera. And the organic soap composition has a shelf-life of about three years, and able to eradicate about 74.6% through 77.6% of the bacterial strain Staphylococcus aureus after at least one minute of direct contact with the composition.

Abstract: New extracts are suggested of Halimione portulacoides or sea purslane, and related species of Halimione, obtainable by treating the said plant with a solvent selected from the group consisting of C1-C4 aliphatic alcohols, ethyl acetate, water or their mixtures, removing the dissolved extracts from the residues and recovering the pure extracts from the solvent. The extracts show excellent properties particularly in modulating the metabolism of human skin and hair follicles.

Abstract: A process for the production of a Camellia sinensis dedifferentiated stem cell extract, the process comprising the steps of: (a) Preparing a cell culture comprising Camellia sinensis dedifferentiated stem cells; (b) Performing an extraction on the cell culture using ethanol and/or methanol as an extraction solvent, to produce the Camellia sinensis dedifferentiated stem cell extract.

Abstract: The present specification discloses a composition for preventing hair loss or promoting hair growth comprising, as an active ingredient, extracellular follicles derived from lactic acid bacteria, and a method for preparing the extracellular follicles derived from lactic acid bacteria. The composition has an effect of preventing and prohibiting hair from falling off from the scalp or becoming thin or tapered. In addition, the composition has an effect of implementing a hair growth function for generating new hair, or a function for promoting the hair growth, as well as a function of promoting a delay from an anagen to a catagen phase of a hair cycle and a function of growing the existing hair healthy.

Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Abstract: Provided are knottin-drug conjugates. The conjugates include a knottin peptide that includes an engineered loop that binds to a target on a cancer cell surface, and a drug (e.g., a nucleoside drug) conjugated to the knottin peptide through a linker. Also provided are pharmaceutical compositions and kits that include the knottin-drug conjugates, as well as methods of using the knottin-drug conjugates, e.g., for therapeutic purposes.

Abstract: The disclosure provides, in part, follistatin polypeptides that are suitable for use in local administration and methods for use.