Abstract: The present invention relates to a cell-free, multi-layered medical device having bespoke, multifunctional bioactivity for the purpose of regeneration of skeletal tissues. The medical device may actively promote homing of stem cells into the medical device and promote their differentiation into the required cell type and promote de-novo tissue formation. The invention includes methods of making the medical device, uses of the medical device in promoting regeneration of the articular cartilage of a joint surface and in promoting healing and regeneration of skeletal tissues, for example, meniscal cartilage, tendon and ligament tissues and also healing of bone tissue indications such as fractures.

Abstract: The present invention aims to provide a tissue regeneration substrate excellent in penetrability to cells as well as capable of effectively preventing cell leakage from the tissue regeneration substrate to accelerate tissue regeneration; and a method of producing the tissue regeneration substrate. The present invention relates to a tissue regeneration substrate including: a nonwoven fabric made of a bioabsorbable material, the tissue regeneration substrate having a laminated structure in which a layer containing a nonwoven fabric having an average pore size of 20 to 50 ?m and a layer containing a nonwoven fabric having an average pore size of 5 to 20 ?m are integrated.

Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).

Abstract: An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate and a hemostatic agent. The substrate includes a first piece and a second piece that is joined with the first piece. The first piece includes the hemostatic agent and the second piece includes an active pharmaceutical ingredient. Kits, systems and methods are disclosed.

Abstract: Dressings, systems, and methods for treating a tissue site on a patient involve allowing liquids from the tissue site or a priming fluid to evaporate and exit the dressing through a liquid-impermeable, vapor-permeable membrane. The dressing is able to process more liquids than would otherwise be possible without evaporation and potentially to create reduced pressure. Other dressings, systems, and methods are disclosed.

Abstract: The invention relates to a container for drainage of fluids or wound secretion, comprising an inlet opening to connect with a drainage line and an outlet opening for releasing waste air accumulated inside the container during drainage, which is characterized in that the container is pre-evacuated, and the outlet opening is sealable, so that the container is transferable in a first and in a second operating condition, wherein in the first operating condition the outlet opening is sealed, so that a suction can be achieved at the inlet opening caused by the vacuum inside the container, and in the second operating condition the outlet opening is opened, so that air can enter the container through the outlet opening and neutralize the vacuum present inside the container.

Abstract: A combination therapy pad that includes a first layer and a second layer operatively coupled to the first layer. A fiber-optic array is disposed between the first layer and the second layer. A third layer is operatively coupled to the first layer. The third layer includes a vacuum tube in fluid communication with a vacuum source and a therapeutic fluid tube in fluid communication with a therapeutic fluid source. The third layer provides at least one of vacuum therapy and therapeutic fluid treatment to a wound area.

Abstract: A system and apparatus for treating a tissue site with reduced pressure and collecting fluids from the tissue site is disclosed. The system may include a reduced-pressure source, a pouch in fluid communication with the reduced pressure source, and a dressing in fluid communication with the pouch. The pouch may include a first wall, a second wall having a periphery coupled to the first wall to form an interior, and a third wall extending through the interior to form a first chamber in fluid communication with the dressing and a second chamber in fluid communication with the reduced pressure source. A plurality of filters are positioned in the third wall. The filters permit fluid communication between the first chamber and the second chamber.

Abstract: A sound suppression system for reducing or eliminating sound produced by the operation of a breast vacuum pump includes a sound suppressing muffler assembly having an air entry port adapted to communicate with an air outlet port of a vacuum pump or other air flow generating device. The sound suppressing muffler assembly also includes a muffler housing defining an internal space communicating with the air entry port, and an opening in the housing leading to atmosphere. The muffler housing has a tortuous air path in the muffler housing. In one embodiment, sound absorbing porous foam structure is disposed in the tortuous air path. The at least one sound absorbing porous structure absorbs sound energy from the air as the air moves through the at least one air path toward the opening in the muffler housing. In further embodiments, a tortuous air path is provided between an air entry port and an opening to atmosphere in the muffler assembly.

Abstract: An implantable blood pump includes an impeller rotatable about a rotational axis, having a body with a bottom surface at a downstream end and a central opening centered about the axis extending at least partially through the body from the bottom surface. A projecting element, e.g., a shaft, extends from below the bottom surface into or through the opening to support the impeller. The body can be configured to drive a primary downstream blood flow along an exterior of the body to beyond a peripheral edge of the bottom surface, and to provide a secondary downstream blood flow through the opening and along the bottom surface to beyond the peripheral edge, the secondary flow improving washing of a bearing surface.

Abstract: An impeller for a pump is disclosed herein. The impeller can include a hub having a fixed end and a free end. The impeller can also have a plurality of blades supported by the hub. Each blade can have a fixed end coupled to the hub and a free end. The impeller can have a stored configuration and a deployed configuration, the blades in the deployed configuration extending away from the hub, and the blades in the stored configuration being compressed against the hub.

Abstract: An example pump thrombosis detection system includes a transducer and processing circuitry. The transducer may be configured to generate a signal representative of a mechanical wave from a mechanical circulatory support device. The processing circuitry is communicatively coupled to the transducer. The processing circuitry may be configured to determine an indication of pump thrombosis based on the signal and, based on the indication of pump thrombosis, control the pump thrombosis detection system to at least one of generate an alert or initiate an intervention.

Abstract: The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool.

Abstract: Embodiments of the disclosure provide a method for evaluating dialyzers used in different medical applications (e.g., hemodialysis). Red blood cell volume lost in a dialyzer is monitored by obtaining blood flowrate measurements and hematocrit measurements at input ports and output ports of the dialyzer. The flowrate and hematocrit measurements are used to determine an accumulation of red cell blood volume in the dialyzer. The measurements may be obtained in a lab environment with an in-vitro blood source or may be obtained in a clinical setting with an in-vivo blood source from a patient.

Abstract: A spectroscopic detection system includes a sensor configured to reflect light of a first wavelength associated with a presence of a reference substance on the sensor and configured to reflect light of a second wavelength associated with a presence of a monitored substance on the sensor, wherein the monitored substance flows to the sensor from a circulating fluid. The spectroscopic detection system further includes a detector that has first and second channels for respectively receiving the light of the first and second wavelengths reflected from the sensor and one or more processors in electrical communication with the detector and configured to identify an excess condition of the monitored substance with respect to the circulating fluid based on a ratio of a second amount of the light of the second wavelength received at the detector to a first amount of the light of the first wavelength received at the detector.

Abstract: Apparatus for use in dialyzing a patient comprising a hemodialysis catheter comprising an elongated body having a proximal and a distal end, wherein the distal end terminates in a substantially planar distal end surface; first and second lumens extending from the proximal end to the distal end, wherein the lumens terminate on the distal end surface in first and second mouths, arranged in side-by-side configuration, and further wherein the lumens are separated by a septum; and first and second longitudinal slots formed in the distal end of the elongated body and communicating with the interiors of the lumens, the slots opening on the distal end surface; wherein the slots each have a length and a width, relative to the dimensions of the lumens and the rate of blood flow to be passed through the hemodialysis catheter, so as to minimize undesirable recirculation of dialyzed blood.

Abstract: Apparatus for use in dialyzing a patient comprising a hemodialysis catheter comprising an elongated body having a proximal and a distal end, wherein the distal end terminates in a substantially planar distal end surface; first and second lumens extending from the proximal end to the distal end, wherein the lumens terminate on the distal end surface in first and second mouths, arranged in side-by-side configuration, and further wherein the lumens are separated by a septum; and first and second longitudinal slots formed in the distal end of the elongated body and communicating with the interiors of the lumens, the slots opening on the distal end surface; wherein the slots each have a length and a width, relative to the dimensions of the lumens and the rate of blood flow to be passed through the hemodialysis catheter, so as to minimize undesirable recirculation of dialyzed blood.

Abstract: A trans anal irrigation device that can be used on a bed. The device includes a rectal catheter connected to an irrigation fluid supply. A waste collection bag is also connected to the catheter. The catheter may be insertable in a seat attached to a fluid supply line. A valve in one of the catheter or seat selectably allows or prevents fluid communication between the catheter and a waste collection bag. The catheter may include an inflationless cuff made of a flexible material that permits it to be inserted in the rectum to prevent leakage around the exterior of the catheter.

Abstract: A device for controlling delivery of a fluid to a patient is disclosed having an injector device having a cylindrical body and a plunger having a head having a valve, the valve capable of opening and closing, the plunger for insertion into the cylindrical body of the injector device. A device for controlling delivery of a fluid to a patient is also disclosed having an inlet end, an outlet end, a side having a portion of elastic material, the elastic material capable of expanding or contracting with the device for insertion between an injector device and a manifold or an injector device and a catheter.

Abstract: In one aspect, a system is provided for administering a formulated food solution. The system includes a syringe body having a collar, a barrel, and at least one protrusion. The system includes a handle configured to be hung on a support and a holder body connected to the handle. The holder body has a central opening sized to receive the syringe body. The holder body includes at least one alignment portion configured to engage at least one protrusion of the syringe body and resist turning of the syringe body in the central opening of the holder body.

Abstract: A fail-safe drug infusion system, including a user interface controller (UIC) and at least one pump motor controller (PMC), with protocols that enable the PMC to operate therapy delivery for a limited amount of time if the UIC fails or the communication link between the UIC and the PMC is interrupted. Includes synchronization methods to synchronize the delivery information back to the UIC after the UIC reboots or after the communication link is restored. The PMC may apply intelligent fail-safe drug infusion therapy by temporarily displaying therapy information, for example information normally displayed by the UIC, while taking control of alarm signaling and providing minimal user control of the therapy until the UIC restores itself, the infusion completes normally, or the user stops the infusion. If the PMC becomes inoperable, the UIC may wait for the PMC to reboot, or attempt to switch infusion channels to provide robust drug infusion.

Abstract: An infusion pump assembly includes an enclosure assembly. A reservoir assembly is positioned at least partially within the enclosure assembly and is configured to contain an infusible fluid. A pump assembly is positioned at least partially within the enclosure assembly and is configured to effectuate the dispensing of the infusible fluid contained within the reservoir assembly. Processing logic is positioned at least partially within the enclosure assembly and is configured to control the pump assembly. A removable cover assembly is configured to releasably engage the enclosure assembly. A combination of the removable cover assembly and at least a portion of the enclosure assembly defines a power supply cavity configured to prevent a removable power supply assembly from being reverse-polarity electrically coupled to the processing logic.

Abstract: A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.

Abstract: A medical system includes an input assembly for receiving one or more user inputs. The input assembly includes at least one slider assembly for providing an input signal. Processing logic receives the input signal from the input assembly and provides a first output signal and a second output signal. A display assembly is configured to receive, at least in part, the first output signal from the processing logic and render information viewable by the user. The second output signal is provided to one or more medical system components. The information rendered on the display assembly may be manipulatable by the user and at least a portion of the information rendered may be magnified.

Abstract: A fluid delivery device comprises a fluid reservoir for containing medicament. The fluid reservoir is sealed proximate one end with a sliding seal piston. A delivery path is configured to fluidly couple the fluid reservoir and a patient wearing the fluid delivery device. A basal engine mechanism is configured to directly or indirectly move the sliding seal piston in the fluid reservoir at a controlled basal rate. A bolus mechanism configured to move the basal engine relative to the fluid reservoir and directly or indirectly move the sliding seal piston in the fluid reservoir a discrete bolus amount at a time.

Abstract: The present invention relates to an injection device for endoscopy, and provides: a feature of inserting a needle for endoscopy into a tissue, in a state of holding a body tissue, which is a region to receive an injection, and then injecting an injection solution thereinto; and a feature enabling stanching of the bleeding region if bleeding occurs. That is, tissue is held by holding forceps and a needle is inserted thereinto, corresponding to a series of operations from a state in which the needle is accommodated between the holding forceps for holding the tissue, and then an injection solution is injected into the tissue through the needle. In addition, a bleeding region is stanched by the heat transferred to the holding forceps without using a separate hemostat if bleeding occurs during the operation.

Abstract: An infusion pump apparatus including a pain controlled analgesic (“PCA”) input device is disclosed. The infusion pump apparatus includes a housing, a pump actuator supported by the housing, and a PCA input device. The infusion pump apparatus also includes electronics configured to control the pump actuator, provide a voltage to the PCA input device, and sense an electrical signal in response to the pain controlled analgesic input device being depressed. The infusion pump apparatus further includes a controller electrically coupled to the electronics and programmed to determine whether the sensed electrical signal is discontinuous, and if the sensed signal is discontinuous, transmit an output indicative of the pain controlled analgesic input device functioning improperly.

Abstract: The present invention relates to a dosing mechanism including: a body (2); and a disposable portion (3) that is removably attached to the body (2), in which the disposable portion (3) includes: a pump that sucks a medicine from a medicine vessel and discharges the medicine to a patient; a suction-side tube (33) that extends from the pump toward the medicine vessel; a discharge-side tube (34) that extends from the pump toward the patient; and a connector (331, 341) that is located at a front end of at least one of the suction-side tube (33) and the discharge-side tube (34), and the body (2) includes a sensor (24) in a position corresponding to the suction-side tube (33) or the discharge-side tube (34) attached to the body (2).

Abstract: A wearable drug delivery device for monitoring unintended over-delivery and/or under-delivery of a stored liquid drug are provided. An absolute pressure sensor can be positioned within the fluid path of the drug delivery device. The absolute pressor sensor can detect both ambient pressure (e.g., absolute or atmospheric pressure) and relative pressure (gage or pumping pressure). Based on the detected pressures, the effects of external ambient pressure on air with the fluid path can be determined during both intended drug delivery events and unintended drug delivery events. In turn, under-delivery and/or over-delivery of the liquid drug can be determined. Based on the severity of the determined under-delivery or over-delivery of the liquid drug, alarms indicating different urgencies can be provided to the user.

Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

Abstract: A reloadable auto injector has a needle insertion driver to be re-activated upon reloading. A syringe is movably positioned in a housing between a first position and a second position. A plunger rod is locked to a plunger rod tube by a deflectable locking member. A syringe driver applies a force to the syringe to move the syringe together with plunger rod tube, plunger rod and plunger rod driver from the first position to the second position. In the second position, the locking member is unlocked and releases the plunger rod to thereby activate the plunger rod driver to advance the plunger rod in the syringe for delivering of medicament. A reload handle is connected to the syringe assembly so that user operation of the reload handle retracts the syringe to the first position and simultaneously reloads the syringe driver for delivering a further dose of medicament.

Abstract: Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

Abstract: Disclosed are plunger assemblies including various convertible plungers and methods of making the same. Each plunger assembly is configured for disposition within a barrel of a medical container, e.g., a syringe, and displaced within the barrel from an engagement position to a release position. The engagement position is configured to provide a compression seal between a storage sealing section of the plunger and an inner wall of the syringe barrel. In the release position, the compression seal is reduced or eliminated. Also disclosed are methods for making convertible plungers and as assembling them into syringes, e.g., pre-filled syringes.

Abstract: A self-injection device (100, 200), including a pen body (108, 208) connectable to a pen needle (10), and a cap (104, 204) selectively connectable to the pen body (108, 208) in a first orientation with respect to the pen body (108, 208) to minimize the length or volume of the self injection device (100, 200), and in a second orientation to provide sufficient length or volume in an interior of the cap (104, 204) to house a pen needle (10) connected to the pen body (108, 208).

Abstract: The safety syringe assembly is for inserting a needle into a patient and comprises a needle hub assembly and a safety cover. The needle hub assembly includes a needle, needle hub, and hub flex unit. The needle is mounted on the front side of the needle hub while the rear side is for receiving a syringe. The safety cover houses the needle hub assembly in a first position during shipping, a second position during insertion of the needle into the patient, and in a third position after the needle has been inserted into the patient while awaiting disposal. A portion of the safety cover includes magnification enabling a user to view a dosage calibration scale, needle bevel and air bubbles. The hub flex unit assumes a first enlarged position during shipping, is compressed during insertion into the patient, and slides into a third position after usage while awaiting disposal.

Abstract: A pneumatically activated retractable-needle syringe comprising a syringe barrel, a plunger, a needle, a needle hub, a locking tip, a propellant gas release cell and a rupture mechanism is provided. The plunger has a retraction lumen defined therein for receiving the needle when the retractable-needle syringe is actuated.

Abstract: A syringe safety device is disclosed herein that comprises a shaft configured to support a barrel of a syringe, a guard configured to be disposed inside the shaft before the syringe is used and to extend outwardly from the shaft after the syringe is used, and a lock disposed between the guard and the shaft having a lock head disposed at a first end thereof, the lock head being disposed in a first aperture in the shaft before the syringe is used and in a second aperture in the shaft after the syringe has been used. A method of using the device also is described.

Abstract: Devices, systems, and methods that may be used to controllably deliver alcohol to a subject using an inhaler, wherein the inhaler may include a housing having a flow channel coupled to an ethanol-containing inhalant reservoir, an actuator configured to facilitate release of the inhalant, a constituent sensor, and a control unit. The control unit may accept parameters associated with the subject, create an inhalant delivery regime, and control operation of the actuator based at least partially on a sensed constituent level to facilitate release of an ethanol-containing inhalant from the reservoir into the flow channel in accordance with the regimen.

Abstract: A dry powder inhaler with a blister folding device can include a housing to receive a single blister containing a dose of medicament for inhalation by a user, and a mouthpiece through which a dose of medicament is inhaled by a user and a blister opening device. The blister opening device can include a blister support element for supporting a blister containing a dose of medicament for inhalation by a user, and a blister folding element co-operable with the blister support element. The blister folding element and the blister support element can be movable relative to each other between a first position, for insertion of the blister into or onto the blister support element, and a second, burst, position in which the blister folding element has co-operated with the blister support element.

Abstract: A dose counting mechanism for indicating the quantity of dosage available within a metered dose inhaler having a canister with an aerosol fluid and a housing body for housing the canister, wherein a wall of the housing body includes formations to support a resilient element, a wheel formation, a elongate threaded element, and a threaded formation including a pointer. The depressing of the canister to release aerosol fluid displaces the resilient element which engages with the wheel formation to rotate the wheel formation. The elongate threaded element engages with the wheel formation such that the rotation of the wheel formation causes rotational movement of the elongate element. The threaded formation engages with the elongate element whereby the rotational movement of the elongate element causes the linear displacement of the threaded formation and the pointer, whereby the position of the pointer indicates the quantity of fluid within the canister.

Abstract: A dry powder inhalation apparatus includes a housing, a reservoir for medicament located within the housing, a mouthpiece disposed on the housing for insertion in the mouth of a user for inhalation of a predetermined dose of medicament, a delivery channel between a discharge outlet of the reservoir and the mouthpiece for delivering the predetermined dose of medicament, a device positioned within the housing and normally held adjacent the reservoir for receiving the predetermined dose of medicament from the discharge outlet and transferring it to the delivery channel, and a release mechanism adapted to release the device and permit controlled movement thereof to the delivery channel for the delivery, the release mechanism being located at least partially outside of the housing for manual operation by the user.

Abstract: Apparatus and methods are described for use with a vaporizer that vaporizes at least one active ingredient of a material. In response to receiving a first input to the vaporizer, the material is heated, in a first heating step. An indication of the temperature of the material is detected, and, in response to detecting an indication that the temperature of the material is at a first temperature, the first heating step is terminated, by withholding causing further temperature increase of the material. The first temperature is less than 95 percent of the vaporization temperature of the active ingredient. Subsequently, a second input is received at the vaporizer. In response thereto, the material is heated to the vaporization temperature, in a second heating step. Other applications are also described.

Abstract: Systems and methods for detecting extubation of an endotracheal tube (ETT) are described. Extubation of the ETT can be identified by comparing to a threshold, a difference between a determined first volume of breathing gas during a first inspiratory period to a determined second volume of breathing gas during a second inspiratory period. If the difference exceeds the threshold, an alarm can be activated indicating extubation. Extubation detection may also be based on a difference between inspiratory pressures during separate inspiratory periods. Partial extubation and full extubation may also be discerned. Further, extubation of an ETT may be detected without the use of an exhalation flow sensor.

Abstract: Aspects of the subject technology relate to a control device for a medical ventilator. The control device has a user definable medical ventilator protocol and is configured to select a plurality of objects from a group of objects, wherein each of the objects are segments of the ventilator protocol, and each of the objects has at least one attribute. Further, the control device is configured to arrange the plurality of objects in a sequence, initiate the at least one attribute to define a property for each object in the plurality of objects, and execute the sequence. The medical control device gives the user flexibility to define and implement a medical ventilator protocol in a faster way than possible today and for different patients and/or ventilator situations.

Abstract: A gas washout vent for a patient interface may be configured to allow a flow of patient exhaled gas to an exterior of the patient interface to minimise rebreathing of exhaled gas by the patient and the vent may include: a plurality of vent passages extending between a first and a second side of the vent, each vent passage may include: a plurality of first openings extending from the first side towards the second side, said first openings being uniform in size and shape; a plurality of second openings extending from the second side towards the first side, said second openings being uniform in size and shape; and wherein the first openings and the second openings partially overlap each other at an interface to form constricted passages therebetween.

Abstract: An endotracheal tube (ETT) system and methods are provided. In at least one example, an ETT system may comprise, a tube, inflatable cuff coupled to the tube, and a restrictor. In at least one example the restrictor may comprise one more cavities. In a further example, a restrictor drainage assembly may be coupled to the restrictor, the restrictor drainage assembly configured to drain secretions that may be collected at a collection point formed by the restrictor when the ETT system is positioned in an airway of a patient and in an inflated state.

Abstract: A mask is disclosed that has a gas outlet which is quiet and provides for a diffused outlet flow of gases. The outlet is preferably a slot formed between a hollow body and cover over said hollow body. The mask also preferably extends and seals under a user's chin in use.

Abstract: A patient interface device is for use in a pressure support system delivering a flow of breathing gas to an airway of a patient. The patient interface device includes a sealing apparatus having a cushion structured to sealingly engage about the airway of the patient and defining a passage therethrough which is structured to receive the flow of breathing gas. A first magnetic material is coupled to the cushion, and a second magnetic material coupled to the cushion or another element of the sealing apparatus. The second magnetic material and the first magnetic material are configured such that there is a repulsive magnetic force therebetween. The coupling of the first magnetic material and the second magnetic material provides an adjustable coupling that provides selective adjustment of the magnitude of the repulsive magnetic force.

Abstract: A cushion tension assembly for a respiratory interface device is provided. Cushion tension assembly includes an adjustment assembly and a number of tension members. Each tension member is operatively coupled to the adjustment assembly and is operatively coupled to the cushion body. In this configuration, the adjustment assembly is structured to move cushion body between a first configuration in which the cushion body provides a generally continuous seal, and a second configuration in which the cushion body provides a more complete seal.

Abstract: A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.