Abstract: A valve structure for treating a patient suffering from obstructive sleep apnea is provided. The valve structure is connected to an air flow generator and connected to a mask that covers at least the nostrils of a patient. The valve structure includes a housing with an inlet pressure port connected to the air flow generator, and an ambient pressure port. Within the housing is an expiratory membrane, an expiratory valve seat, an inspiratory membrane, an inlet pressure valve seat, an inspiratory valve seat, and an inspiratory membrane segmentation structure configured to segment the movement of the inspiratory membrane into at least a first portion and a second portion. An expiratory valve in fluid connection with the inlet pressure port is formed by the expiratory membrane and the expiratory valve seat. An inlet pressure valve is formed by the inlet pressure valve seat and the first portion of the inspiratory membrane.

Abstract: The present disclosure, in one embodiment, is a computer-implemented method for the detection of and intervention in traumatic nightmares. In one embodiment, a user wears a watch wirelessly connected to a phone. The watch may include an accelerometer, gyroscope, and heartrate monitor. The application may monitor these sensors and intervene with haptic feedback if the application detects a traumatic nightmare. In one embodiment, the application may include a monitoring module that collects data from the watch's accelerometer, gyroscope, and heartrate sensors. The application may then estimate and record stress levels based on these sensors. The application may also include an intervention module that responds to high stress levels with haptic feedback that increases in intensity of previous efforts to intervene were unsuccessful.

Abstract: The invention primarily is directed to a medical tubing adapted for insertion into a body tissue or cavity and method of manufacturing different variations of the tubing along a length of the tubing. The tubing comprises a plurality of individual, discrete, generally ring-shaped elements arranged in series and fused or bonded together forming a continuous tubular structure. The ring-shaped elements may include a combination of flexible and rigid ring-shaped elements assembled along different portions or sections of the tubular structure. In another aspect of the invention, the medical tubing may further comprise a secondary lumen and a pull wire to control the tubular structure. In another aspect of the invention, the ring-shaped elements may vary in diameter and/or composition in different portions or sections of the tubular structure.

Abstract: A urinary catheter assembly includes a catheter shaft, a drainage funnel associated with the distal end of the catheter shaft, and a gripping member. The distal end of the gripping member is fixedly secured to the drainage funnel, while an extendable portion of the gripping member allows its proximal end to be moved along the length of the catheter shaft toward and away from the proximal end of the catheter shaft. The extendable portion of the gripping member encircles at least a portion of the catheter shaft when the proximal end of the gripping member is moved toward the proximal end of the catheter shaft, thereby allowing for the gripping member to be used to manipulate the catheter shaft without directly touching the catheter shaft.

Abstract: A method is provided for facilitating urine output from the kidney, including: (a) inserting a catheter including: a drainage lumen including a distal portion configured to be positioned in a patient's kidney, renal pelvis and/or in the ureter adjacent to the renal pelvis and a proximal portion, the distal portion including a retention portion including a funnel support including at least one sidewall, wherein the funnel support includes a first diameter and a second diameter, the first diameter being less than the second diameter, the second diameter being closer to an end of the distal portion of the drainage lumen than the first diameter, wherein the proximal portion of the drainage lumen is essentially free of or free of openings; and (b) applying negative pressure to the proximal portion of the drainage lumen for a period of time to facilitate urine output from the kidney.

Abstract: A device for accommodating and magnetizing a tissue-penetrating medical device of various lengths, with or without a cover covering a portion or the entirety of the tissue-penetrating medical device, is disclosed including a sleeve member having an open proximal end, a distal end, an inner surface, an outer surface having a graduated injection depth gauge to indicate needle penetration depth when the cover is placed into a magnetizer, and a hollow body extending between the proximal end and the distal end to form a protective closure over a shaft of a tissue-penetrating medical device. Also disclosed is a needle cover having a fixed distance between the tip of the needle and the tip of the needle cover. A device having one or more magnetizing elements sectioned into a plurality of movable segments pivoting around an axis to accommodate needles with different lengths is also disclosed.

Abstract: A detector and a method of its use with a guidewire to reduce the incidence of guidewires accidently being left inside patients during the placement of central venous (and other) catheters. In particular, an electronic detector detects whether a catheter has been placed over a guidewire and whether the guidewire has been removed thereafter. In addition, the distance the guidewire has progressed out the patient side of the detector housing which will correspond to the length of guidewire actually inside the patient and any time may be provided.

Abstract: A dilator for sheathless access to a vessel of a patient, having a distal portion with a maximal outer diameter that extends from a distal end to a guidewire exit port and a proximal portion with a reduced profile that extends from the guidewire exit port to the proximal end and a lumen that extends between the distal end and the guidewire exit port. A first guidewire may be positioned within the vessel and the dilator advanced over the guidewire. A guide catheter may then be advanced over the dilator.

Abstract: A medical device is disclosed for delivering a medical member which is intended to indwell in a treatment site of a urethra includes a flexible main body that extends in an axial direction, a balloon that includes an effectively dilatable portion on which the medical member is mounted, that has a dilating space into which a pressurizing medium flows between an outer surface of the main body and the balloon, and that is capable of dilating deformation and deflating deformation, an elongated guide member that is arranged across the treatment site and the outside of a living body via the urethra, and an attachment portion to which at least a portion of the guide member is detachably attached at a position between both end portions in the axial direction of the main body.

Abstract: A syringe assembly or inflation device that includes a detachable housing. A pressure-sensing syringe assembly or inflation device can include both a syringe barrel and a housing that is coupled to the syringe barrel in a locked configuration. The inflation device can transition from the locked configuration to the unlocked configuration in which the housing is separable from the syringe barrel. Related methods are also disclosed.

Abstract: A content inflation and delivery system including a container including a fluid inlet in fluid communication with a fluid outlet; wherein the fluid outlet is positioned between the fluid inlet and a second end of the container. The system also includes an inflatable content being configured for inflation and delivery from the second end of the container.

Abstract: A system for use in prevention of stroke is provided that has a shaft that carries an occluding balloon. The occluding balloon is inflated to occlude blood flow through at least one of a right carotid artery and a left carotid artery. An actuation device for causing inflation of the occluding balloon is present. The inflation is applied in a cyclical nature based upon a cardiac cycle. The cyclical inflation of the occluding balloon in turn causes a resulting cyclical occlusion.

Abstract: A medical device with an expandable element and expandable tubular sleeve surrounding at least a portion of the expandable element which influences the rate, shape and/or force required to expand the expandable element and methods for use in a body lumen are provided.

Abstract: A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.

Abstract: A medical fluid drainage system which may be advantageously used to actively absorb excess fluid from an interstitium in a living host and to transport it from an inlet member 1 in a non edematous body part out of an outlet member 4 via pumps (5, 6, 7) built in series, such as a distal area with functional lymphatic vessels, or directly in a lymphatic vessel, or directly in a blood vessel.

Abstract: A medical tube 10 (drain tube 10) includes a main shaft tube 20, a flow path opening/closing mechanism 40, and a branch tube 30. The main shaft tube 20 internally has a main shaft side distal opening 21a and a main shaft lumen 21. The flow path opening/closing mechanism 40 brings the main shaft lumen 21 into a communicating state by applying pressure smaller than predetermined pressure, and brings the main shaft lumen 21 into a blocked state by applying pressure equal to or greater than the predetermined pressure. The branch tube 30 promotes a pancreatic juice pj to flow into a branch lumen 31, based on the applied pressure which is equal to or greater than the predetermined pressure.

Abstract: Methods for treating hydrocephalus using a shunt, the shunt having one or more CSF intake openings in a distal portion, a valve disposed in a proximal portion of the shunt, and a lumen extending between the one or more CSF intake openings and the valve, the method comprises deploying the shunt in a body of a patient so that the distal portion of the shunt is at least partially disposed within a CP angle cistern, a body of the shunt is at least partially disposed within an IPS of the patient, and the proximal portion of the shunt is at least partially disposed within or proximate to a JV of the patient, wherein, after deployment of the shunt, CSF flows from the CP angle cistern to the JV via the shunt lumen at a flow rate in a range of 5 ml per hour to 15 ml per hour.

Abstract: A single lumen catheter with extendable and retractable drains for providing improved fluid drainage and irrigation. The catheter generally includes a housing enclosing a single unpartitioned lumen, a plurality of drain ports, and a common drain. A plurality of drains provide a plurality of paths for fluid to flow between the common drain and the exterior of the housing. The plurality of drains are coupled to an internal connector within the single lumen, and are selectively movable via the internal connector and a stylet with a specially shaped end tip between a retracted position in which the drains are enclosed within the lumen and an extended position in which the drains extend through the drain ports to the exterior of the housing. Additionally or alternatively one or more elongated tools or other elements can be coupled to the internal connector and caused to move between retracted and extended positions.

Abstract: The present invention relates to a device for the topical treatment of pain affecting the vulvar area of the female human genital organ, a formulation for use in the device according to the invention, and a kit comprising the device according to the present intention. Additionally, the present invention relates to a method of topical treatment of pain affecting the vulvar area of the female human genital organ, said method using the device according to the present invention. The device is a layered article shaped to be placed in use inside a female undergarment and at least partially in skin contact with the female vulvar area and comprises a topical formulation.

Abstract: The invention relates to applicators for applying a solution or other composition (e.g., an antiseptic composition) to skin of a patient. The applicator may include a container body having a proximal end, a distal end, and a frangible member disposed at the distal end of the body. The applicator includes a first position where the container body and frangible member are a unitary piece (e.g., blow molded as a single piece), and a second position when the frangible member is rotated relative to the body to irreversibly break a weak point therebetween, releasing the composition in the hollow body through an opening. A porous applicator head may be positioned adjacent the distal end of the body and frangible member, so that the composition flows out the body, through the opening, and onto the head. The applicator may be formed in a blow-fill-seal process for improved sterility and ease of manufacture.

Abstract: Exemplary systems and methods associated with trans-tissue substance delivery using non-thermal plasma to porate skin or tissues using contoured dielectrics/electrodes and grounding techniques. In some embodiments, a substance delivery system may be incorporated into the plasma generating device for automatically controlled skin treatments. In other embodiments, a skin treatment patch may include the electrode and the treatment substance.

Abstract: Systems and methods are disclosed for transporting a transport target across a membrane that is impermeable or semi-permeable to the transport target via artificially created microchannels or through hypodermic microneedles. The transport target can be a medicant and the membrane can be a stratum corneum layer of skin. The transport is enhanced by the application of ultrasound energy having a high peak intensity, which generates an inertial cavitation effect, an acoustic streaming effect, or both.

Abstract: A valve body, e.g. a valve body adapted to be disposed in a connector to be connected to a catheter, has an opening/closing part which opens upon inserting a member into the opening/closing part and which closes upon withdrawing the member from the opening/closing part. The valve body includes a main body part made of a silicone rubber and a surface layer disposed on a surface of the main body part. This surface layer serves as a sliding surface which, when a guide wire has been inserted into the opening/closing part, slides on the guide wire. The surface layer is constituted mainly of silicon oxide and hence improves the sliding properties of the guide wire. Thus, the valve body is reduced in the resistance of sliding on the guide wire.

Abstract: A hemostatic valve assembly is disclosed. The assembly comprises a housing having a sidewall that tapers radially inwardly towards the housing distal end. A valve member having an open proximal end and a tapered distal end with an orifice formed therein is disposed within the housing chamber. The valve member is deformable between a closed configuration in which the orifice is substantially closed and an open configuration in which the orifice is open. A biasing member disposed proximal to the valve member is moveable between a longitudinally compressed condition and a longitudinally expanded condition. When in an expanded condition, the biasing member pushes the valve member longitudinally and against the tapered sidewall of the housing. The tapered sidewall of the housing urges the distal end of the valve member radially inwardly, thus urging the orifice to the substantially closed configuration.

Abstract: Aspects of the present disclosure include a connector that is suitable for connecting medical suction tubing with at least two different types of fluid ports of a medical fluid collection system. In certain aspects, the connector includes a generally cylindrical body portion having a cylindrical outer surface extending generally parallel to a central longitudinal axis of the body portion, and an inner surface defining a primary conduit extending through the connector. At least one lateral closure wall extends radially outward from the outer surface of the body portion. At least one annular skirt wall extends longitudinally from the at least one lateral closure wall, including a first annular skirt wall that serves to receive an open mouth of a first fluid port having a relatively small diameter, and a second annular skirt wall that serves to receive an open mouth of a second fluid port having a relatively larger diameter.

Abstract: A breaker device (1) for acting onto a closure element (40) of a medical tubing (4) comprises a drive arrangement (2) having an electric drive device (20) and a drive element (23) driven by the drive device (20), and a breaker module (3) which is arrangeable on the drive arrangement (2). The breaker module (3) comprises a housing (30), a movable part (31) movably arranged on the housing (30) and a breaking element (315) for acting onto the closure element (40) of the tubing (4), wherein the breaker module (3) in an attached state is placed on the drive arrangement (2), the drive element (23) being in operative connection with the movable part (31) in the attached state such that a movement of the drive element (23) causes the movable part (31) to move for actuating the breaking element (315). A control device (5) serves for controlling the electric drive device (20) for driving the drive element (23).

Abstract: A system and method for providing therapy to a patient can include a monitoring unit and a therapy unit. The monitoring unit can have a user interface and one or more sensors to measure patient data. The therapy unit can have a stimulator for generating electrical stimulation and a microcontroller for controlling the generation of the electrical stimulation based on the measured patient data.

Abstract: A cutaneous electrode device intended for being connected to an electrical pulse generator including a planar body and an electrically insulating material on which at least one electrode, at least one means for connecting to the electrical pulse generator and at least one conductive element electrically connecting said electrode to said connection means are formed. The at least one electrode ends at an inner surface of the body and the at least one connection means ends at an outer surface of the body. The body also has at least one projecting portion that is mechanically connecting an electrode and a connection.

Abstract: A lead body having a defibrillation electrode positioned along a distal portion of the lead body is described. The defibrillation electrode includes a plurality of electrode segments spaced a distance apart from each other. At least one of the plurality of defibrillation electrode segments includes at least one coated portion and at least one uncoated portion. The at least one coated portion is coated with an electrically insulating material configured to prevent transmission of a low voltage signal (e.g., a pacing pulse) while allowing transmission of a high voltage signal (e.g., a cardioversion defibrillation shock). The at least one uncoated portion is configured to transmit both low voltage and high voltage signals. The lead may also include one or more discrete electrodes proximal, distal or between the defibrillation electrode segments.

Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Abstract: A subcutaneous implantable medical device and method (SIMD) provided. A pulse generator (PG) is configured to be positioned subcutaneously within a lateral region of a chest of a patient. The PG has a housing that includes a PG electrode. The PG has an electronics module. An elongated lead is electrically coupled to the pulse generator. The elongated lead includes a first electrode that is configured to be positioned along a first parasternal region proximate a sternum of the patient and a second electrode that is configured to be positioned at an anterior region of the patient. The first and second electrodes are coupled to be electrically common with one another. The electronics module is configured to provide electrical shocks for antiarrhythmic therapy along at least one shocking vector between the PG electrode and the first and second electrodes.

Abstract: Bacteria, cancer cells, fungus and other harmful cells located beneath the surface of a mammal body can be effectively destroyed by passing an electrical current through the area to be treated. Electrodes are positioned on either side of the area to be treated, for example, gums, fingers, arms, legs, feet and torso, and an electric current is caused to flow between the electrodes and through the area to be treated. The electric current will destroy the bacteria, cancer cells, fungus or other harmful cells.

Abstract: Methods and systems for treating sleep disordered breathing by stimulating nerves that innervate the palatoglossus and/or the palatopharyngeus muscle are provided. Such therapy can be used in conjunction with hypoglossal nerve stimulation.

Abstract: The disclosed electrical stimulation system generates interventions to assist patients in complying with a diet. The wearable device includes a microprocessor, electrical stimulator and at least one electrode configured to deliver electrical stimulation to the epidermis, through a range of 0.1 mm to 10 mm or a range of 0.1 mm to 20 mm of the dermis, of a T2 dermatome to a T12 dermatome or meridian of the patient, a C5 to a T1 dermatome across the hand and/or arm, and/or the upper chest regions. The device is adapted to provide electrical stimulation as per stimulation protocols and to communicate wirelessly with a companion control device configured to monitor and record appetite patterns of the patient and deliver titrated therapy. The control device is also configured to monitor, record, and modify stimulation parameters of the stimulation protocols.

Abstract: The present disclosure provides a method and device for filtering sensor data. Signals from an array of sensor pixels are received and checked for changes in pixel values. Motion is detected based on the changes in pixel values, and motion output signals are transmitted to a processing station. If the sum of correlated changes in pixel values across a predetermined field of view exceeds a predetermined value, indicating sensor jitter, the motion output signals are suppressed. If a sum of motion values within a defined subsection of the field of view exceeds a predetermined threshold, indicating the presence of a large object of no interest, the motion output signals are suppressed for that subsection.

Abstract: Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal.

Abstract: An example a system includes a neuromodulation generator that may be configured to use electrodes to generate a first modulation field over a test region of neural tissue along the electrodes to prime the neural tissue throughout the test region and a second modulation field to test targeted locations within the test region for therapeutic effectiveness. A memory may be configured to store a first modulation field parameter for generating the first modulation field and a second modulation field parameter set for generating the second modulation field to modulate a targeted location within the test region. The second modulation field parameter set is programmable for modulating other targeted locations. The controller may be configured to control the neuromodulation generator to use the first modulation field parameter set to deliver the first modulation field and to use the second modulation field parameter set to deliver the second modulation field.

Abstract: Methods of stimulating a nerve may include inserting a lead structure into one or more blood vessels. The lead structure may include an insulating member, first electrodes and second electrodes supported on the insulating member, and at least one metal lead. The first electrodes and second electrodes may be positioned in one or more blood vessels. The methods of stimulating a nerve may further include the lead structures being applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.

Abstract: The present application discloses am electrical stimulation device for electrically stimulating at least one target zone of an organism. The electrical stimulation device comprises a control unit and an electrical stimulation unit. The electrical stimulation unit includes a frequency synthesizer, an amplifier, a variable resistor, at least one first electrode and at least one second electrode. The frequency synthesizer is coupled to the control unit and generates a frequency signal. The amplifier is coupled to the frequency synthesizer. The variable resistor comprises a resistance and is coupled to the control unit and the amplifier. The first electrode and the second electrode are coupled to the amplifier. The amplifier outputs an electrical stimulation signal according to the frequency signal of the frequency synthesizer and the resistance of the variable resistor to impel the first electrode and the second electrode to generate an electric field.

Abstract: An example method for controlling delivery of electrical stimulation therapy includes maintaining, by one or more processors of a medical device configured to deliver electrical stimulation to a patient, a counter tied to a clock used by the medical device to deliver the electrical stimulation to the patient; and obtaining, by the one or more processors, one or more representations of sensed electrical signals for the patient that are referenced to counts of the counter. In this example, the method also includes identifying, based on the one or more representations of the sensed electrical signals for the patient, a count of the counter at which stimulation is to be delivered to the patient; and delivering, by the medical device and to the patient, electrical stimulation based on the identified count of the counter.

Abstract: A medical device is configured to deliver a high-energy electrical stimulation pulse to a patient that produces a post-stimulation polarization signal. A cardiac signal analyzer of the medical device is configured to detect a cardiac electrical signal superimposed on the post-stimulation polarization signal, determine at least one feature of the detected cardiac electrical signal, compare the feature to criteria that differentiate an intrinsic cardiac event during the post-stimulation polarization signal from an evoked response signal and identify the detected cardiac electrical signal as the intrinsic cardiac event if the feature meets the criteria.

Abstract: An implantable medical device (IMD) is configured with a pressure sensor. The IMD includes a housing, a pressure sensor and a fluid filled cavity. The housing has a diaphragm that is exposed to the environment outside of the housing. The pressure sensor has a pressure sensor diaphragm that is responsive to a pressure applied to the pressure sensor diaphragm and provides a pressure sensor output signal that is representative of the pressure applied to the pressure sensor diaphragm. The fluid filled cavity is in fluid communication with both the diaphragm of the housing and the pressure sensor diaphragm of the pressure sensor. The fluid filled cavity is configured to communicate a measure related to the pressure applied by the environment to the diaphragm of the housing to the pressure sensor diaphragm of the pressure sensor.

Abstract: Implementations described and claimed herein provide systems and methods for delivering and retrieving a leadless pacemaker. In one implementation, a leadless pacemaker has a docking end, and the docking end has a docking projection extending from a surface. A docking cap has a body defining a chamber. A retriever has sheaths extending with lumens distally from the chamber. A snare extends between the lumens forming a first snare loop pointing in a first direction and a second snare loop pointing in a second direction with a docking space formed therebetween. The snare is movable between an engaged position and a disengaged position by translating the first snare wire and the second snare wire within the first snare lumen and the second snare lumen. The engaged position includes the first snare wire and the second snare wire tightened around the docking projection within the docking space.

Abstract: A system for supplementing communications capabilities of a patient monitoring device, the system including an interface device configured to communicably couple with and to receive the patient monitoring information from the patient monitoring device, a memory device hosted by the interface device and configured to store at least a portion of the patient monitoring information, a wireless transceiver hosted by the interface device, a database hosted by the interface device; and a processor communicably coupled to the wireless transceiver and the asset management database, the processor configured to format the patient monitoring information into one or more data objects, each of the one or more data objects associated with an EMS incident during which the patient monitoring information was gathered, the processor further configured to store the one or more data objects to the database and to transmit the one or more data objects with the wireless transceiver.

Abstract: The present disclosure provides systems and methods for assembling a subassembly for use in manufacturing an implantable device header. A method includes placing a first split web into a top platen, placing a second split web into a bottom platen, placing a conductor assembly and an antenna assembly in the bottom platen on top of the second split web, compressing the top and bottom platens together, heating the top and bottom platens until a predetermined temperature and a predetermined pressure are reached, such that first split web is fused to the second split web to form the subassembly, separating the top and bottom platens, and removing the formed subassembly.

Abstract: An implantable cardioverter defibrillator (ICD) and methods of detection and treatment of dangerous and life-threatening heart rhythms by delivering real-time, customized low-energy pacing pulses to specific anatomy in the heart. The ICD includes a power source, a controller, powered by the power source, including an electronic processor, a memory, and a signal generator. The ICD also includes a lead coupled to the controller and an electrode that is in electrical communication with a His-bundle of a patient's heart. The ICD detects a ventricular arrhythmia of the patient's heart using the controller, and is configured to provide a pulsed defibrillation signal to the electrode to terminate the ventricular arrhythmia.

Abstract: A medical device is configured to deliver anti-tachycardia pacing (ATP) in the presence of T-wave alternans. The device is configured to detect a ventricular tachyarrhythmia from a cardiac electrical signal received by the medical device. In response to the detected ventricular tachyarrhythmia, the device delivers a plurality of ATP pulses at alternating time intervals. The alternating time intervals comprise at least a first ATP time interval separating a first pair of the ATP pulses and a second ATP time interval different than the first ATP time interval. The second ATP time interval consecutively follows the first ATP time interval and separates a second pair of the ATP pulses.

Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.

Abstract: Disclosed are devices, methods, and systems for helping to prevent (or preventing) or treat brain and/or body disorders. Embodiments of the invention have utility for enhancing cognitive function during aging. The invention utilizes electromagnetic stimulation (EMS) that can provide a range of EMS parameters and modalities. The EMS may be utilized in conjunction with physiologic sensors that can provide feedback for possible EMS modifications.

Abstract: A device for breaking down fatty tissue using inductive magnetic fields includes a stimulation coil replaceably attached to a stand and accommodated in a plastic housing, a variable-height pedestal, and a pivotable camera integrated in the stand for observing muscle contractions that are triggered. An operating console features control software for computer-aided optimization of one or more stimuli, and a pulse generator for electrically actuating a magnetic field coil. A spotlight may be included for correctly illuminating the area of the body captured by the camera. A method for breaking down fatty tissue is also described.