Abstract: Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx1 protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier.

Abstract: The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

Abstract: A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.

Abstract: The disclosure pertains to N-terminal epitopes identified in A-beta, including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

Abstract: Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same.

Abstract: The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.

Abstract: The protein known as six-transmembrane epithelial antigen of prostate 2 (STEAP2) is highly expressed in prostate cancer and is associated with the expression of other prostate cancer-associated genes. The present invention provides novel full-length human IgG antibodies that bind to human STEAP2 (monospecific antibodies). The present invention also provides novel bispecific antibodies (bsAbs) that bind to both STEAP2 and CD3 and activate T cells via the CD3 complex in the presence of STEAP2-expressing tumors. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human and monkey CD3, and a second antigen-binding molecule that specifically binds human STEAP2. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing STEAP2.

Abstract: The present invention is related to a targeted type shell for drug delivery system. The object of the present invention is to provide the targeted type shell for DDS, which comprises a carbosilane dendrimer containing a silole produced by which is formed by utilizing the reaction between thiol group and alkyl halide, and a targeted protein containing a labeled proteins such as green fluorescent protein with a target recognition site. The shell may incorporate compounds having a variety of molecular weight and biopolymers, and selectively deliver them into targeted cells.

Abstract: The invention relates to the use of a CITED4 polypeptide and/or a microRNA-222 or precursor (e.g., pre-miR-222) or mimic thereof, for treating a cardiovascular disease or pathological condition, such as heart failure, myocardial infarction, and for promoting post-myocardial infarction cardiac remodeling in heart tissue.

Abstract: The invention relates to a pharmaceutical composition including a plurality of lipid nanoparticles having a mean particle size of between 80 nm and 160 nm and containing an mRNA encoding a polypeptide. The lipid nanoparticles include a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid. The mRNA contains a 5?-cap, 5?-UTR, a 3?-UTR, and a poly-A region with at least 100 nucleotides.

Abstract: Disclosed is a monoclonal antibody reactive with a glycopeptide shown in (a), and not reactive with a glycopeptide shown in (b)

Abstract: A method of damaging a parasite while being a resident in or on a surface of a body of a mammal. The method comprises irradiating the parasite with ultrasound radiation at a frequency of from about 1 MHz to about 2.6 MHz for a period of at last one second.

Abstract: A sterilization method and system are disclosed, where a sterilization cycle includes at least an evacuation step of a sterilization chamber is performed one or more times and provides that: the chamber is isolated from the condenser; at least a steam generator is operated to inject a predetermined amount of heated steam directly into the condenser; the steam in the condenser is cooled and condensed, so as to reduce its volume and accordingly lower the pressure within the condenser to below that present in the sterilization chamber; and the condenser is placed in communication with the sterilization chamber to perform an evacuation.

Abstract: A sanitizer includes a shell defining first and second chamber portions, and having an opening into the first portion. A cover has a closed position over the opening for preventing access to the chamber, and an open position for permitting access to the chamber. A tray is moveable between an access position in the first portion, for placement and retrieval of an article within the tray, and a sanitizing position in the second portion, for exposing the article to sanitizing electromagnetic radiation from an emitter mounted in the second portion. A controller controls an actuator coupled to the tray to move the tray to the sanitizing position when the cover is closed, and to return the tray to the access position when a return condition is satisfied. A radiation barrier is configured to substantially prevent radiation from reaching the opening when the tray is in the access position.

Abstract: Systems are disclosed which include processor-executable program instructions for receiving data regarding characteristics of a room and determining, based on the received data, operating parameter/s for one or more disinfection sources to disinfect the room. The data may include data regarding non-physical characteristics and/or physical characteristics of the room. In some embodiments, data regarding a quantity and/or type of at least a subset of the plurality of disinfection sources for disinfecting the room may also be considered for determining the operating parameter/s. In any case, the determined operating parameter/s may include a run time of a disinfection source, a position of a disinfection source within the room, a speed at which a disinfection source moves throughout the room, an orientation of a component comprising a disinfection source, a rate of germicidal discharge from a disinfection source and/or power supplied to a disinfection source.

Abstract: A method and apparatus for disinfecting a lavatory inside a vehicle in response to a set of criteria being met. A determination is made as to whether a set of criteria for activation of a disinfection system that emits far-ultraviolet radiation to perform a disinfection process inside a lavatory has been met. In response to a determination that the set of criteria has been met, the disinfection system is activated to perform the disinfection process inside the lavatory using the far-ultraviolet radiation.

Abstract: Sterilization containers, components, and methods thereof. A locking mechanism is used to secure and release a filter assembly on a sterilization container includes two opposing buttons that, when compressed toward each other, unlock the locking mechanism and, when released, secure the locking mechanism.

Abstract: A perfume retainer includes a main body and an air flow channel located in the main body. The air flow channel includes: a retainer space configured to retain a perfume, a first opening located connecting a first end of the retainer space to a space outside of a first end of the air flow channel, and a second opening connecting a second end of the retainer space to a space outside of a second end of the air flow channel. The retainer space includes a plurality of segment regions arranged adjacent each other such that an external wall of one of the plurality of segment regions is in contact with an external wall of another of the plurality of segment regions. The plurality of segment regions increase a surface area of the air flow channel without increasing a volume of space of the air flow channel.

Abstract: The stretchable porous film of the present invention includes voids in a surface thereof, in which: the stretchable porous film has an air permeability measured with an Oken-type air permeability meter of less than 99,999 sec/100 cc; the stretchable porous film has such an extending direction that an air permeability measured with the Oken-type air permeability meter in a state in which the stretchable porous film is extended by 100% becomes less than 60,000 sec/100 cc; and the stretchable porous film has such a pulling direction that when, in a hysteresis test, the stretchable porous film is pulled from a width of 20 mm and an inter-chuck distance of 30 mm to an inter-chuck distance of 60 mm at a pulling speed of 50 mm/min and held for 1 minute, and then the pulling of the inter-chuck distance is released, a residual strain becomes 10 mm or less.

Abstract: The invention relates to a device for adsorbing odours comprising an absorbent layer and an adsorbent layer, said adsorbent layer being provided with a material permeable to volatile organic compounds (VOCs) and an adsorbent particulate filler comprising at least one spice. Such a device is particularly useful for adsorbing and masking body odours.

Abstract: Embodiments of the present technology may permit for native, intact, natural, human-derived, or allograft-derived fibers to be used as threads for suturing. Embodiments may include a thread for suturing. The thread may include a first portion, which includes a fascia fiber. The first portion may have a first end that includes the fascia fiber. The thread may also include a second portion including a non-human-derived fiber. The second portion may have a first end that includes the non-human-derived fiber. The first end of the second portion may be attached to the first end of the first portion. Embodiments may include a method of forming a thread. The method may include attaching a first end of a fascia fiber to a first end of a first non-human-derived fiber. The method may also include attaching a second end of the fascia fiber to a first end of a second non-human-derived fiber.

Abstract: Provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase.

Abstract: Disclosed are a vascular patch using a silk matrix and a method of manufacturing the same, wherein the vascular patch is configured such that a silk matrix having a cross-section with a first thickness, produced from silkworms, is subjected to planar division into two or more silk matrix pieces having a predetermined shape with the first thickness. Furthermore, the manufacturing process is relatively simple, thus reducing the manufacturing cost compared to when manufacturing typical vascular patches, and also, the vascular patch can exhibit outstanding cell culture capacity and is biocompatible.

Abstract: The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following surgical reconstruction.

Abstract: The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.

Abstract: The present invention relates to a polyacrylamide hydrogel for use in prevention and/or treatment of synovitis or pain associated with synovitis in a mammal by formation of an extra layer to the synovial membrane i.e. a sub-synovial layer and a novel synovial lining layer. Synovitis may occur in association with arthritis, such as osteoarthritis or rheumatoid arthritis, lupus, or gout, and the mammal suffering from synovitis is a preferably a human, a racing animal or a companion animal.

Abstract: A soft tissue filler comprising a biodegradable amino-acid derived polycarbonate-urethanes and methods of repairing soft tissue defects are provided. The biodegradable soft tissue filler comprises a porous scaffold that is the reaction product of: a) a divinyl oligomer component that comprises a carbonate-derived divinyl oligomer that is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and a polycarbonate and, optionally, an ether-derived divinyl oligomer, wherein the ether-derived divinyl oligomer is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and an ether; b) at least one anionic monomer; and c) at least one hydrophobic monomer. The molar ratio of (a):(b+c) is between about 1:?21 and about 1:30, the soft tissue filler has a porosity of >75%; and a compressive moduli of between about 1 kPa and about 50 kPa.

Abstract: A medical device includes a body defining an exterior surface, and a coating including a therapeutic agent-containing nanoparticle disposed on the exterior surface of the medical device. The nanoparticle may include a brush-arm star polymer. The therapeutic agent may be paclitaxel.

Abstract: A medical device such as a stent (10) or medical balloon (40) is functionalised prior to coating with a bioactive material (54), specifically by acidification or basification of the contact surface or surfaces (50) of the medical device. Functionalisation with subsequent coating of bioactive agent directly onto the functionalised surface provides a significantly more consistent and reliable coating of bioactive agent on a medical device without requiring containment or time release devices.

Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.

Abstract: A method of forming a silicone coating on an electrode carrier for use in cochlear implant systems includes dissolving silicone and dexamethasone in a solvent to form a solution, adding a non-solvent to the solvent, the non-solvent miscible with the silicone and the dexamethasone having a solubility in the non-solvent of below about 5 mg/ml, and curing the solution to form the silicone coating on the electrode carrier.

Abstract: Methods and systems for sizing fat parcels are provided. In particular, a parcelizer device that includes a container and a displacement insert or filter element is provided. Tissue containing fat parcels is passed through the parcelizer. The parcelizer can include multiple displacement inserts or filter elements. Alternatively or in addition, a plurality of displacement structures that each include one or more displacement inserts or filter elements can be provided. In general, the displacement inserts or filter elements are configured to progressively reduce the size of fat parcels included in tissue.

Abstract: A device for draining bodily fluids is described herein which generally may comprise an elongate body defining one or more lumens configured to receive a bodily fluid from a cavity, e.g., bladder, of a patient body. The one or more lumens are in fluid communication with a reservoir which may receive the bodily fluid. A pumping mechanism may be used to urge the bodily fluid through the one or more lumens, where the pumping mechanism is configured to maintain an open space within the one or more lumens such that outflow of the bodily fluid through the one or more lumens remains unobstructed such that a negative pressure buildup in the cavity is inhibited. The device may also include a vent or valve mechanism in communication with the elongate body to allow air to enter or exit the one or more lumens.

Abstract: A wound dressing comprises a wound pad and a backing layer on a non-wound facing side of the backing layer. At least a portion of a sealing ring is provided within 5 mm of and continuously along the contour of the wound pad. A negative pressure wound treatment system comprising such a wound dressing is also disclosed.

Abstract: A system, apparatus, and method for treating a tissue site with reduced pressure includes a connector having a connector body. The connector body includes a cavity and a cavity aperture. The connector also includes a conduit port fluidly coupling a conduit to the cavity. The connector further includes a base adjacent the cavity aperture that is configured to be positioned adjacent a drape. The cavity is configured to be fluidly coupled to a manifold through an aperture of the drape. The connector also includes a sensing probe having a proximal end configured to be fluidly coupled to the conduit and a distal end extending to the cavity aperture. The distal end is configured to be positioned adjacent to and in fluid communication with a manifold.

Abstract: A directed media separation system includes components for directing a consistent collapse of a media separation device in response to a varying pressure from a pressure source. The media separation device can be removably connected to a directing element. The directing element can have a directing geometry that affects the collapse of the media separation device. The media separation device can have a preset geometry that collapses in a predictable and repeatable manner from the applied pressure.

Abstract: A blood pump comprises a pump casing, a blood flow inlet and a blood flow outlet connected by a passage, and an impeller. The impeller comprises blades configured to convey blood from the blood flow inlet to the blood flow outlet, the impeller being supported in the pump casing by at least one contact-type bearing comprising a surface of the impeller facing a surface of the pump casing. At least one wash out channel extends through the impeller and is in fluid connection with the passage via a first opening and with the bearing via a second opening. The wash out channel is operatively associated with a secondary pump for pumping blood through the wash out channel towards the bearing. The secondary pump is formed at least partially by said at least one wash out channel extending through the impeller along a direction having at least one tangential directional component.

Abstract: Mechanical circulatory assist systems and related methods accommodate the connection of a second patient interface module used to control a circulatory assist pump without having to disconnect a first patient interface module used to control the circulatory assist pump. A mechanical circulatory assist system includes a blood pump, a first patient interface module, and a first connector. The first patient interface module is operatively coupled with the blood pump and configured to control operation of the blood pump. The first connector is operatively coupled with the blood pump and configured to couple with a second patient interface module configured to control operation of the blood pump without decoupling of the first interface module from the blood pump.

Abstract: Systems, assemblies, and related modules for connecting components of medical devices employ connector cables with electrical conductors and optical fibers. A connector assembly for coupling a battery module with a medical system including an implanted or worn medical device includes an input connector and an output connector. The input connector includes metal contact plates, has no moving parts, and is sealed to prevent water or dust ingression into the housing. The output connector includes metal pins to electrically couple to the metal plates of the input connector, a connector cable including electrical conductors coupled to the metal pins configured to transmit electrical power and an optical fiber configured to transmit data, and a latching mechanism disposed at an end of the output connector configured to physically attach the output connector to the housing. The cable body has a substantially flat cross-section.

Abstract: In a multi-sensor device for a medical apparatus at least one first sensor unit and at least one second sensor unit are arranged at a fluid-guiding line connection along which the sensor units detect at least one variable from a flowing fluid in predetermined proximity to each other in such manner that predetermined signal portions occur and are detectable practically simultaneously in outputs of each of the first and second sensor units. In a method for defining a proximity in said multi-sensor device, positions of the individual sensors are varied in the multi-sensor device and the occurrence of predetermined signal portions is detected in at least two signals detected by the individual sensors, and those positions at which the predetermined signal portions occur practically simultaneously are defined as positions of the proximity.

Abstract: This dialysis-fluid supply system, which mixes a diluent and at least two drugs to generate a dialysis fluid, and outputs said dialysis fluid, is provided with: two tanks which mix the drugs and the diluent to generate the dialysis fluid, and store said dialysis fluid; a water supply device and a drug supply device which supply the diluent and the drugs to each of the tanks; mechanisms for outputting, to a dialysis device, the dialysis fluid stored in each of the tanks; and a control unit for controlling the driving of these. During output of the dialysis fluid from at least one of the tanks, the control unit sequentially switches the supply destination tank for the drugs and the diluent, and the dialysis-fluid output source tank, between the two tanks in order to generate the dialysis fluid in the other tank.

Abstract: An extracorporeal blood treatment machine, preferably a dialysis machine, including a fluid circuit, preferably a dialysis fluid circuit, and a disinfectant supply line including an SOS generator integrated in the blood treatment machine which can be selectively connected to the fluid circuit by the disinfectant supply line and is adapted to provide a super-oxidized solution or SOS for disinfection of the fluid circuit from dialysis concentrate and osmotic water, and a method for disinfection of an extracorporeal blood treatment machine.

Abstract: A medicated apparatus including a medicated patch for use onto a subject undergoing peritoneal dialysis is disclosed, according to an embodiment of a present invention. The patch includes a medication layer containing a medication therein, and a backing film disposed on one side of the medication layer. The patch also includes a skin adhesive layer disposed beneath the medication layer; and a protective liner disposed beneath the skin adhesive layer. The patch is placed on a catheter by applying pressure to skin of a subject after insertion of the catheter therein, thereby holding the catheter and the medication diffusing into the skin prevents an exit site of infection.

Abstract: A method and system for infusing medical liquid with gasses, the system comprising a gas source, a vacuum pump, a temperature-controlled container including a fluid reservoir coupled to the gas source and the vacuum pump, a heating and cooling system, and a sonicator, and a controller configured to de-gas a liquid in the fluid reservoir by activating the vacuum pump, re-gas the liquid in the fluid reservoir by releasing gas from the gas source to the fluid reservoir via a first fluid line, and deliver the re-gassed liquid from the fluid reservoir to a catheter via a second fluid line.

Abstract: Ports for accessing a vessels within a patient include passageways that can guide needles or other access devices directly into the vessels. The ports can be implanted subcutaneously within a patient. Some ports may be used in the creation and use of vascular access buttonholes.

Abstract: A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.

Abstract: According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.

Abstract: A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that, during a blood returning operation, the first internal pressure calculated by the first internal pressure calculation unit (110) becomes equal to the second internal pressure calculated by the second internal pressure calculation unit (112).

Abstract: Packages comprising a syringe and a blister package are described. The blister package incorporates elements that allow one-handed opening. Also described are methods of removing a syringe from a package using only one hand.

Abstract: This document discusses, among other things, an apparatus comprising a pump configured to deliver a fluid, a wireless communication port and a controller. The controller is configured to communicate with a separate device via the communication port to receive information relating to a calendar event stored on an interactive calendar of the separate device. The controller can alter operation of the apparatus based on the calendar event.