Abstract: An ophthalmic instrument includes a carrier positionable relative to a test subject, and first and second measurement units mounted on the carrier by corresponding first and second parallelogram linkages. The first measurement unit, for example an autorefractor/keratometer, performs a first type of ophthalmic measurement, and is guided by the first parallelogram linkage to move relative to the carrier simultaneously in forward and downward directions from an idle position to a measurement position. The second measurement unit, for example a tonometer, performs a second type of ophthalmic measurement, and is guided by the second parallelogram linkage to move relative to the carrier simultaneously in forward and upward directions from an idle position to a measurement position. The first and second measurement units may each have a respective optical axis which aligns with a fixed measurement axis of the carrier when the measurement unit is in its measurement position.

Abstract: A method of screening a pupil of a subject to determine whether the pupil reflex resembles a canonical pupil reflex is disclosed. The method comprises the steps of stimulating the pupil with a stimulus source, such as a pupilometer and determining whether one of various pupillary response conditions is met.

Abstract: An ophthalmologic imaging apparatus of an embodiment includes a data acquisition device, photographing device, a controller, and an error detector. The data acquisition device acquires data by scanning a subject's eye using optical coherence tomography. The photographing device photographs the subject's eye to obtain a front image. The controller controls the data acquisition device to perform a series of scans along a preset path group. The error detector detects an error based on a series of data acquired by the series of scans and two or more front images that include one or more front images obtained by photographing device corresponding to the series of scans.

Abstract: A vision protection method is provided to ensure a viewer to rest his/her eyes after viewing on an electronic device for a certain period, wherein the eyesight protection method includes the steps of detecting at least one of eye activities of the viewer and working parameter of the electronic device in a working mode of the electronic device during the viewer is working on a current work displaying by the electronic device; switching the working mode of the electronic device to a resting mode when an abnormal eye activity of the viewer is detected; and switching the electronic device from the resting mode back to the working mode to resume the display of the current work of the electronic device. Therefore, the viewer is enforced to rest his/her eyes after every certain period.

Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).

Abstract: A system includes a wearable head apparatus and an electronic console. The head apparatus is configured to receive resultant light from the head of a subject. The electronic console includes a fiber array, a detector, and a computing device. The fiber array includes a plurality of fibers configured to transport resultant light received by the head apparatus. The detector includes a plurality of super-pixels each defined by a plurality of pixels of an array of pixels. Each super-pixel is associated with a fiber. Each super-pixel is configured to generate a plurality of detection signals in response to detected resultant light from its associated fiber. The computing device receives the detection signals from each of the plurality of super-pixels. The computing device generates a high density-diffuse optical tomography (HD-DOT) image signal of the brain activity of the subject based on the detection signals from the super-pixels.

Abstract: A near-infrared spectroscopy (NIRS) sensor assembly for measuring a characteristic of a biological tissue is provided. The NIRS sensor assembly includes a light source, at least one light detector, and a layer disposed within the sensor assembly. The light source is operable to emit light at one or more predetermined wavelengths. The at least one light detector has an active area for detecting light emitted by the light source and passed through the biological tissue. The light detector is operable to produce signals representative of the detected light. The layer disposed within the sensor assembly has at least one deflection element.

Abstract: Embodiments of the invention are directed to a non-contact optical method using a probe beam deflection technique (PBDT) to detecting acoustic waves transiting an acoustic coupling medium.

Abstract: An insert includes: an insert body that has an opening and has an inner cavity therein; a light guide member that is inserted into the inner cavity of the insert body and guides light emitted from a light source; a light emitting portion that emits light guided by the light guide member; a light absorption member that generates photoacoustic waves by absorbing the light emitted from the light emitting portion; and a proximal end portion that has an inlet of liquid and a chamber communicating with the inlet and the inner cavity of the insert body. The inner cavity has a space for flow of the liquid, and liquid injected through the inlet is capable of flowing from the opening of the insert body through the chamber and the space for flow of the liquid.

Abstract: A system to measure blood pressure of a person comprises a software that is configured to obtain two or more sensor information from one or more sensor near simultaneously. The sensor information comprises data points, from which at least one data feature can be derived. Based on the data features derived from the data points, a value of the cardiovascular time delay can be derived. The system can further derive a blood pressure value based on the cardiovascular time delay, and provide the value of the blood pressure, the cardiovascular delay, or other metrics derived from the cardiovascular delay to a user. The sensors can be placed in one or more mobile or wearable devices, which can communicate with each other wirelessly.

Abstract: A vehicle seat in accordance with the present disclosure includes a seat bottom and a seat back. The seat back is coupled to the seat bottom and arranged to extend in an upward direction away from the seat bottom. The vehicle seat further includes an electronics system.

Abstract: Devices and methods for monitoring blood pressure with a wearable device, which includes a contact member that concentrates radially directed tissue movement produced by arterial motion into a relatively small spot to compress the strain device. This concentration significantly increases the sensitivity of the force detecting device and allows further miniaturization of the device.

Abstract: Systems and methods are provided for determining the frequency of a cardiovascular pulse based on a first physiological signal that is continuously available and a second physiological signal that is less available and that is more accurate or otherwise improved relative to the first signal with respect to pulse rate estimation. When the second signal is available it controls the determination of the pulse rate. When the second signal is unavailable, the first signal is used to determine the pulse rate. This can include using the first signal to estimate the pulse rate until the second signal is available, at which point the pulse rate is estimated based on the second physiological signal. Alternatively, the first signal could be used to determine a number of candidate pulse rates, and the second signal could be used to select a pulse rate from the set of candidate pulse rates.

Abstract: The present method is a method for executing a computational fluid analysis on a blood flow at a blood vessel region to be analyzed, and displaying the analysis results, comprising the steps of: obtaining, by a computer, a vascular diameter (d) of an inlet and/or outlet of a blood vessel region to be analyzed from medical images which include said blood vessel region; obtaining, by the computer, an estimated flow rate (Q) at the inlet and/or outlet based on the vascular diameter (d); and applying, by the computer, the estimated flow rate (Q) to a blood flow characteristics pattern of said blood vessel region and outputting blood flow characteristics at the inlet and/or outlet of the analysis object site.

Abstract: In one embodiment, a cardiac mapping system includes a medical examination device to capture data over time at multiple sample locations over a surface of at least one chamber of a heart, a display screen, and processing circuitry to process the captured data to determine a description of a propagation of activation wavefronts associated with activation times over the surface of the at least one chamber of the heart, calculate activation wavefront propagation path traces wherein each path trace describes a point on one activation wavefront being propagated over the surface of the at least one chamber of the heart according to an advancement of the activation wavefront such that the path traces describe the propagation of different points according to corresponding activation wavefronts, prepare a visualization showing the path traces on a representation of the at least one chamber, and render the visualization to the display screen.

Abstract: The exemplary systems and methods may be configured for use in the determination of ectopic beat-compensated electrical heterogeneity information. Electrical activity can be monitored by a plurality of external electrodes. Ectopic beat information can be detected. Ectopic beat-compensated electrical heterogeneity information can be generated based on the monitored electrical activity and the detected ectopic beat information.

Abstract: Systems and methods for analyzing electrophysiological signals acquired from a subject are provided. In some aspects, a method includes receiving electrophysiological signals acquired from a subject using one or more sensors, and assembling a set of time-series data using the acquired electrophysiological signals. The method also includes analyzing the set of time-series data using a state-space multi-taper framework to generate spectral information describing the electrophysiological signals, and determining a brain state of the subject using the spectral information. The method further includes generating a report indicative of the determined brain state.

Abstract: A wearable device includes a case, a bio-processor embedded in the case, and a plurality of electrodes connected to the bio-processor. The bio-processor is configured to selectively and respectively operate the electrodes as sensing electrodes and sourcing electrodes in response to a selection signal. The selected one/ones of the electrodes operated as sensing electrodes which pick up a biological signal from (e.g. biological activity or a biological condition of) the wearer. The selected one/ones of the electrodes operated as sourcing electrodes supply current to the wearer regulated to cause the desired biological signal to be picked up by the sensing electrode(s).

Abstract: An electrophysiology data acquisition system that receives physiological signals from at least one catheter includes an amplifier and at least one noise reduction circuit operatively connected to the amplifier and configured to cancel interference in the physiological signals from the catheter. A drive selection circuit is controllable to connect any one of two or more available electrodes to the noise reduction circuit such that the connected electrode becomes an equalization drive electrode for the catheter. An equalization control module is executable on a processor and configured to select the equalization drive electrode from the two or more available electrodes and to control the drive selection circuit to connect the selected equalization drive electrode to the noise reduction circuit.

Abstract: One example of a device includes a sensor, a memristor code comparator, and a controller. The sensor is to provide a sensor signal. The memristor code comparator is to compare the sensor signal to a reference signal. The controller is to determine a status of the sensor signal based on the comparison.

Abstract: Systems and methods for detecting atrial arrhythmias such as atrial tachyarrhythmia (AT) are described herein. An AT detection system may include a heart rate detector circuit configured to detect, from a physiological signal, representative ventricular heart rates within heart rate analysis windows. An atrial tachyarrhythmia detector circuit may perform an initial rate detection using a first ventricular heart rate statistic generated from the representative ventricular heart rates, and to perform a sustained arrhythmia detection using one or more second ventricular heart rate statistics generated within a second plurality of heart rate analysis windows during a specific duration. An AT event is detected if the second ventricular heart rate statistics satisfy a specific condition throughout the specific duration. The AT detection system may include an output unit that may output the detected AT to a user or a process.

Abstract: Provided are a method, a device, a system, and a program for evaluating similarity of brain activity with respect to an object to be evaluated, using data obtained by a simple measurement of brain waves. Brain wave data related to cognitive processing with respect to a plurality of sensory stimuli are dimensionally compressed, and a distribution of the object to be evaluated is displayed on a two-dimensional plane or three-dimensionally. In this way, similarity of brain information with respect to the plurality of sensory stimuli is evaluated, and the similarity is visualized. The brain wave data related to the cognitive processing include brain wave data upon selection of a stimulus as a target, and brain wave data caused by a non-target stimulus event.

Abstract: The present disclosure pertains to a system configured to adjust an intensity of sensory stimulation delivered to a subject during a sleep session based on sleep spindles in the subject during the sleep session. The system is configured to adjust the intensity of the stimulation based on a sleep spindle frequency and/or a sleep spindle density. The system is configured to determine a recent spindle density and/or a recent spindle frequency for a recent period of time during the sleep session based on detected sleep spindles, and to determine a previous spindle density and/or a previous spindle frequency for a previous period of time during the sleep session based on the detected sleep spindles. The system controls the intensity of sensory stimulation provided to the subject based on a comparison of the previous spindle density to the recent spindle density and/or the previous spindle frequency to the recent spindle frequency.

Abstract: Disclosed is a sensor for measuring skin conductivity and a method of manufacturing the same, wherein the sensor includes: a base board made of a flexible material; an electrode provided on a surface of the base board, and transmitting an electrical signal; and an uneven structure provided on the electrode, and configured to increase an electrical contact area with skin via sweat secreted onto a surface of skin.

Abstract: A fat thickness estimating device includes a storage unit that stores information indicating relationship between fat thickness and ratio of bioelectrical impedance in a first condition and bioelectrical impedance in a second condition, a measured impedance value acquiring unit configured to acquire a measured impedance value in the first condition of a target living body and a measured impedance value in the second condition of the target living body, and an estimation unit configured to calculate a fat thickness value in the target living body based on the information and a ratio of the measured impedance value in the first condition and the measured impedance value in the second condition.

Abstract: Various devices are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a disposable cartridge containing a reactive material that extracts the analyte from a breath sample passed through the cartridge. In some embodiments, the cartridge contains a solid, porous structure (such as a disk, bowl or puck) that contains the reactive material. The porous structure may be created by mixing reactive particles with resin particles, and then using a sintering process to transform the mixture into a solid structure. Also disclosed are devices for routing a breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

Abstract: This invention relates to a breathing tube for use in ultrasonic flow measurement systems for determining the volume flow and/or the molar mass of the respiration of humans and animals. According to the invention, the breathing tube at least partly has a polygonal cross-section. Furthermore at least one indicator is formed on the breathing tube, which can be read out via an external optical device.

Abstract: A respiratory air measuring device is provided through which a measuring air stream flows for measuring at least one component of the respiratory air of a patient. The respiratory air measuring device includes a sensor device and a flow generator disposed downstream for generating a measuring air stream. A flow nozzle is disposed in a channel portion to affect flow, wherein a generator air stream coming from the flow nozzle creates the measuring air stream. The respiratory air measuring device may be partially disassembled for effective cleaning.

Abstract: A system and method for reducing intrafractional motion of a subject The system includes a subject user device, whereby the user device includes an image acquisition device configured to receive location marker information of the subject to provide location marking data of the subject. The system may also include a digital processor configured to: receive the location marking data and determine movement of the subject relative to the location marker information; and communicate feedback of the movement to the subject to help the subject reduce intrafractional motion.

Abstract: A device and method for measuring the angle and range of motion of a body joint used in the course of medical treatment. Index marks are placed on the limbs of the patient that correspond to registration indicators on the arms of the device. This allows consistent application of the device in measurement sessions over time to ensure consistent measurements of the joint. A fixed display and a wireless broadcast of the angle are for reading the angles of the joint.

Abstract: A system and method for assessing fine motor functions based on user input patterns. The method comprises collecting raw data related to at least an interaction of a user with a computing device; computing, based on the raw data, at least one biometric attribute; generating a session pattern based on the at least one biometric attribute; and generating using the session pattern and a decision model a scale index indicating a current condition of the fine motor functionality of the user data.

Abstract: A watching assistance system that assists watching over a subject on a bed includes an image acquisition unit configured to acquire an image captured by an imaging device, a criterion storage in which a criterion for determining a dangerous state are previously set for each of a plurality of determination regions set based on a region of the bed in the image, a detector configured to detect the subject from the image acquired by the image acquisition unit, a state recognition unit configured to recognize a state of the subject detected by the detector, a determination unit configured to determine a danger degree of the state of the subject recognized by the state recognition unit using the criterion for the determination region corresponding to a position at which the subject is detected by the detector, and an output unit configured to provide notification according to the danger degree determined by the determination unit.

Abstract: A method for determining hearing thresholds in the absence of pure-tone testing includes an adaptive speech recognition test which includes a calibrated item pool, each item having a difficulty value (di) and associated standard error (se). Test items are administered to a group of individuals having mild to moderately severe hearing loss to obtain responses. The responses are subjected to multiple regression statistical methods to develop an equation for converting an individual's test score to hearing threshold values at several frequencies. The adaptive speech recognition test can be administered to an individual and their score can be converted into hearing thresholds at each of the several frequencies by use of the equation.

Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.

Abstract: Disclosed is a non-invasive biometric sensor including a light source, an organic photodetector, and a detector. The light source is configured to irradiate light in a desired (and/or alternatively predetermined) wavelength range to a body part. The organic photodetector is configured to sense the light in the desired (and/or alternatively predetermined) wavelength range in response to the light in the desired (and/or alternatively predetermined) range being transmitted through the body part. The detector is configured to determine biomedical information of the body part based on an amount of the light sensed by the organic photodetector.

Abstract: An oximeter probe determines an oxygen saturation for the tissue and determines a quality value for the oxygen saturation and associated measurements of the tissue. The quality value is calculated from reflectance data received at the detectors of the oximeter probe. The oximeter probe then displays a value for the oxygen saturation with the error value to indicate a quality level for the oxygen saturation and associated values used to calculate oxygen saturation.

Abstract: A method for in-vivo cancer diagnosis within a living tissue. The method includes preparing an electrochemical probe by fabricating three integrated electrodes via coating a layer of vertically aligned multi-walled carbon nanotubes (VAMWCNTs) on tips of three electrically conductive biocompatible needles, putting the tips of the three integrated electrodes in contact with a portion of the living tissue by inserting the tips of the three integrated electrodes into the portion of the living tissue, recording an electrochemical response from the portion of the living tissue, where the electrochemical response may include a cyclic voltammetry (CV) diagram with an oxidation current peak corresponding to a hypoxic glycolysis chemical reaction in biological cells within the portion of the living tissue, and detecting a cancer-involving status of the portion of the living tissue based on the oxidation current peak.

Abstract: There is disclosed a transdermal analyte sensor device. The device includes a sensor cartridge having a membrane permeable to a target analyte transdermally received from a subject, a reservoir containing a fluid to receive the target analyte through the membrane and an enzyme to react with the target analyte to form a byproduct, a working electrode to generate an electrical current based on a concentration of a byproduct, and a cartridge electrical contact to transmit the electrical current. The device also includes a device body having a device electrical contact to receive the electrical current from the cartridge electrical contact, a transmitter to transmit a signal based on the electrical current to a monitoring device, and a cartridge receptacle to receive the sensor cartridge and position the membrane to contact skin of the subject.

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided.

Abstract: The invention provides the supporting system for neurological state assessment and neurological rehabilitation, especially within cognitive and/or speech dysfunction, characterized in that, the processing unit (PU) is integrated with the screen (S), which is equipped with the touch input sensors (TIS), said camera and light sources work within infrared radiation, wherein the infrared camera (IFC) is integrated with at least two infrared light sources (ILS). The infrared light sources (ILS) and the infrared camera (IFC) are formed into a movable component (MC) in the way that the infrared light sources (ILS) are located symmetrically and uniaxially on both sides of the infrared camera (IFC) in the movable component (MC). The movable component (MC) is connected with the processing unit (PU) through the screen (S). In another aspect the invention provides the method for supporting of neurological state assessment and neurological rehabilitation, especially within cognitive and/or speech dysfunctions.

Abstract: Provided are systems and methods for medical diagnosis. The systems and methods may identify a coherence between paired sensor data respectively measured from a first sensor attached to a head of a subject and a second sensor attached to a body part of the subject. The systems and methods may determine an amount of volition in the subject's body based on the coherence. The systems and methods may determine a diagnosis or a treatment plan for a subject based on the amount of volition. The system and methods may be used to track interaction between individuals in a clinical setting or in a social group.

Abstract: An apparatus assesses an arousal level of a driver of a vehicle. The apparatus includes a processor and a memory storing a computer program, which when executed by the processor, causes the processor to perform operations. The operations include acquiring personal data of the driver, which are detected by one or more sensors when the vehicle is traveling. The operations also include developing, by machine learning with the acquired personal data, a model for estimating an arousal level to personalize the model to the driver, and determining the arousal level of the driver based on the personalized model.

Abstract: A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome taxonomic features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

Abstract: A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome taxonomic features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

Abstract: A display apparatus includes a display which displays a screen including a plurality of photo contents containing a user face and a processor configured to control the display to distinguishably display the plurality of photo contents based on a photographing time of the plurality of photo contents with reference to a time at which a preset event related with skin has occurred.

Abstract: An evaluation method of evaluating a color irregularity site (a blemish) includes a color irregularity site detection step (step S102) of detecting a plurality of color irregularity sites respectively from a first skin image and a second skin image different from the first skin image, a gravity center position calculation step (step S108) of calculating gravity center positional coordinates of the color irregularity sites respectively for the first skin image and the second skin image, and a matching process step (step S110) of matching the plurality of color irregularity sites included in the first skin image with the plurality of color irregularity sites included in the second skin image based on the calculated gravity center positional coordinates of the color irregularity sites.

Abstract: Methods and systems are presented for determining physiological information in a physiological monitor. A physiological signal (e.g., an EEG signal) received from a subject is wavelet transformed and first and second related features that vary in scale over time are identified in the transformed signal. First and second coupled ridges of the respective first and second related features may also be identified in the transformed signal. A non-stationary relationship parameter is determined and is indicative of the relationship between the first and second features and/or between the first and second ridges. Physiological information, which may be indicative of a level of awareness of a subject, is determined based on the non-stationary relationship parameter.

Abstract: The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a treatment delivery system for treating a subject in response to changes in the severity of a subject's symptoms. The present invention further provides for a system and method, which can accurately quantify symptoms of movement disorders, utilizing continuously obtained kinetic information to be analyzed, accurately distinguishing between symptoms of movement disorders and activities of daily living, relating quantified symptoms to a standard clinical rating scale, and correlating a subject's symptoms with certain physiological and environmental factors. The present invention still further provides for home monitoring of symptoms in subjects with these movement disorders in order to capture the complex fluctuation patterns of the disease over the course of days, weeks, months, or years.

Abstract: The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a drug delivery system for dosing a subject in response to the increased severity of a subject's symptoms. The present invention provides for a system and method, which can accurately quantify symptoms of movements disorders, accurately quantifies symptoms utilizing both kinetic information and electromyography (EMG) data, that can be worn continuously to provide continuous information to be analyzed as needed by the clinician, that can provide analysis in real-time, that allows for home monitoring of symptoms in subject's with these movement disorders to capture the complex fluctuation patterns of the disease over the course of days, weeks or months, that maximizes subject safety, and that provides remote access to the clinician or physician.

Abstract: This invention generally relates to methods useful for measuring heart rate, respiration conditions, and oxygen saturation and a wearable device that incorporate those methods with a computerized system supporting data collection, analysis, readout and sharing. Particularly this present invention relates to a wearable device, such as a wrist watch or ring, for real time measuring heart rate, respiration conditions, and oxygen saturation.