Abstract: A method for treating a breathing condition includes providing a face strip having an adhesive layer and a mesh layer disposed on the adhesive layer and applying the adhesive layer to a mouth of a patient diagnosed with a breathing condition comprising at least one of a dry mouth, a sore throat, nasal congestion, or hypoxia. The method further includes covering the patient's mouth with the face strip and providing resistance from the face strip at the patient's mouth, and increasing nasal respiration with the face strip. The face strip reduces or prevents the incidence of the breathing condition.

Abstract: A system for aligning a patient interface for use in delivering a flow of a breathing gas to the airway of a patient with an adhesive arrangement that is structured to secure the patient interface to the patient. The system includes a base that is structured to be disposed on a surface, the base having a central member protruding upward from the base to a contoured surface. The central member includes a pair of protruding alignment elements that extend further upward from the contoured surface and which are sized and structured to engage apertures in both of the adhesive arrangement and the patient interface in a manner which aligns such components with each other.

Abstract: An adhesive arrangement for use in securing a patient interface to the face of a patient includes a substrate material having a first surface that is structured to face the patient and a second surface opposite the first surface. The substrate material includes a number of tabs, each tab projecting outward from a main portion of the substrate material. The adhesive arrangement further includes an adhesive material disposed on the first surface of the substrate material. Each of the tabs is sized and configured to be folded back onto a corresponding portion of the main portion of the substrate material and coupled thereto by the adhesive material.

Abstract: A battery retaining system for a portable oxygen concentrator includes a first rail configured to receive a first slide of a battery, a second rail configured to receive a second slide of the battery, the second rail being spaced apart from the first rail so as to form a channel configured to receive the battery, and a flexible stiffening mechanism configured to impart a biasing force on a surface of the battery when the battery is received within the channel. The flexible stiffening mechanism includes a protrusion projecting from the first rail at least partially towards the second rail and a slit positioned behind the protrusion and configured to facilitate travel of the protrusion fore and aft.

Abstract: A pressure swing adsorption (PSA) system and methods for controlling each PSA cycle performed by the PSA system to produce oxygen enriched gas during productive portions of a user breathing cycle, and to cease production of oxygen enriched gas during non-productive portions of the user breathing cycle, is provided. The PSA system synchronizes PSA cycle phases including adsorption and desorption phases with a user's individual inhalation and exhalation phases, on a breath by breath basis, such that each PSA cycle can be dynamically varied from a succeeding PSA cycle, in real time in response to variations in the user's breathing cycle. An oxygen delivery device including a breathing cycle sensor provides breathing cycle inputs to a controller for use with at least one algorithm to detect breathing flow phases during each user breath, and to synchronize each PSA cycle to the user's breathing flow phases, on a breath-by-breath basis.

Abstract: A control system controls fresh gas dispensing for an anesthesia device, with a patient gas-measuring unit, an anesthetic-dispensing unit, a user interface, and a fresh gas regulation unit. With a transition from deactivated assistance mode to activated assistance mode, a processing unit receives a measured signal, a fresh gas signal and an assistance signal and calculates an end tidal anesthetic concentration over time based on a current volume flow, a predefined volume flow and on a current end tidal anesthetic concentration and stores this as a preset curve. A fresh gas correction signal is output upon the determined current end tidal anesthetic concentration leaving a surrounding range of the preset curve. A predefined volume flow curve is changed as a function of the correction signal. The volume flow of fed fresh gas is increased when the surrounding range is undershot and is reduced when the surrounding range is exceeded.

Abstract: The present invention relates to a respiratory device with a housing comprising a pneumatic unit and at least one further component, in particular a respiratory gas drive, and at least one measuring unit, and also an expiration unit, an accumulator, a control unit and a cooling fan. The pneumatic unit is designed as a pneumatic conveying line which is removable from the housing and which is formed and arranged from an appliance inlet to an appliance outlet of the housing and comprises a support frame on which are arranged at least one component, in particular the respiratory gas drive, at least one sound unit, at least one flow measurement path, at least one measuring unit and the cooling fan.

Abstract: A breathing assistance apparatus that comprises a housing with inner and outer walls and an upper surface, wherein the walls and upper surface are integrally formed as a single part to avoid seams or joins between the walls to reduce the risk of damage to electronics within the apparatus as a result of liquid leaks. Also disclosed is a control system for a heating element of a humidifier which provides a secondary or back up protection mechanism to disable power to the heating element if a first electronic protection circuit does not cause the first switching member to disable power to the heating element.

Abstract: A respiratory pressure therapy (RPT) device is disclosed for treatment of respiratory-related disorders. The RPT device includes a pressure generator, a pneumatic block, a chassis and a device outlet for delivering a supply of flow of gas to a patient interface. The RPT device also comprises an integrated humidifier including a water reservoir. An RPT device is also disclosed that includes a wireless data communication interface integrated with the housing and configured to connect to another device or a network.

Abstract: A respiratory assistance apparatus (4) is provided, adapted to deliver gases to a user or patient (1). The apparatus (4) comprises a housing (10) provided with a chamber (5) and a heater (25), the chamber (5) comprising at least one gas port (15) connected to, or arranged to be connected to, at least one intermediate passageway (12). The apparatus (4) is operative according to a disinfection mode of predetermined profile in which the heater (25) heats liquid in the chamber (5) to produce vapour at or above a target dewpoint temperature and/or humidity level. The apparatus (4) is arranged such that the vapour is delivered to the intermediate passageway (12) to disinfect the intermediate passageway (12) with moist heat throughout a predetermined duration of the disinfection mode. Associated attachments and methods are also provided.

Abstract: A ventilation system including a ventilator having a cooling fan configured reduce an internal temperature of the ventilator. The ventilator also includes a controller configured to control operation of the ventilator. A detector is configured to generate a detection signal when the ventilator is connected to a cold passover humidification (CPH) device. In response to the detection signal, the ventilator reduces or eliminates operation of the cooling fan in comparison to a default mode of operation. A method of providing increasing a temperature of a flow of air to a CPH device is also included.

Abstract: Aspects of the present disclosure provide a smart relaxation mask configured to output a stimulus and collect biometric information while the stimulus is output to determine if the subject is paying attention to the stimulus. If the subject is not focused on the stimulus, the mask adjusts at least one of an audio, visual, or haptic output. The stimulus is adjusted in an effort to shift the subject's attention to the stimulus and away from racing thoughts.

Abstract: Typically, high NREM stage N3 sleep detection accuracy is achieved using a frontal electrode referenced to an electrode at a distant location on the head (e.g., the mastoid, or the earlobe). For comfort and design considerations it is more convenient to have active and reference electrodes closely positioned on the frontal region of the head. This configuration, however, significantly attenuates the signal, which degrades sleep stage detection (e.g., N3) performance. The present disclosure describes a deep neural network (DNN) based solution developed to detect sleep using frontal electrodes only. N3 detection is enhanced through post-processing of the soft DNN outputs. Detection of slow-waves and sleep micro-arousals is accomplished using frequency domain thresholds. Volume modulation uses a high-frequency/low-frequency spectral ratio extracted from the frontal signal.

Abstract: A system for delivering sensory stimulation comprises a sensor configured to measure brain activity information of a patient during a sleep session; a sensory stimulator configured to deliver sensory simulation to the patient during the sleep session; and a computer system. One or more physical processors are programmed with computer program instructions which, when executed cause the computer system to: determine a first stimulation profile, a second stimulation profile, or a combination stimulation profile thereof based on obtained sleep cycle information and/or obtained cognitive domain information; and provide input to the sensory stimulator based on the determined stimulation profile, the provided input causing the sensory stimulator to deliver the sensory simulations to the patient based on the determined stimulation profile during the detected slow wave sleep in the patient.

Abstract: A system for delivering sensory stimulation comprises a sensor configured to measure autonomic nervous system activity information of a user during a sleep session; a sensory stimulator configured to deliver sensory simulation to the user during the sleep session; and a computer system. One or more physical processors of the computer system are programmed with computer program instructions which, when executed cause the computer system to: obtain the autonomic nervous system activity information of the user; determine parasympathetic nervous system information based on the obtained autonomic nervous system activity information of the user; and provide input to the sensory stimulator based on the determined parasympathetic nervous system information, the provided input causing the sensory stimulator to deliver the sensory stimulation to the user based on the determined parasympathetic nervous system information.

Abstract: A sleep mask including a front side, wherein the front side is a layered fabric, a back side, wherein the back side is a layer fabric, a top, a bottom, a left side, a right side, an adjustable strap, the strap connected to the left and right sides, eye pockets, wherein the eye pockets are located on the back side, a nasal arch having a top, a first side, and a second side, wherein the nasal arch is located substantially in the center of the bottom, a light shield, the light shield attached around the nasal arch on the back side, and two diffuser holders fixedly attached to the first and second sides of the nasal arch, wherein each diffuser holder has an interior cavity and an opening, wherein the opening is smaller than the interior cavity, wherein the interior cavity is adapted to receive diffuser material.

Abstract: A method for promoting continuous sleep of a subject by eliminating and/or preventing sleep associations includes: (a) providing an apparatus including at least one sensor and at least one output device; (b) monitoring a state of the subject using the apparatus; (c) determining the subject is in an awake state using the at least one sensor; (d) in response to determining the subject is in the awake state, initiating and maintaining an output using the at least one output device; (e) determining the subject is in a sleep state using the at least one sensor; (f) halting the output in response to determining that the subject is in the sleep state such that the apparatus does not produce any output; (g) repeating at least step (b) during a sleep session. The method further includes modifying an intensity of the output over time until the intensity reaches zero.

Abstract: A method of aiding sleep includes a person seeking to sleep using a finger to touch and move the finger over at least part of a tactile region located on bedwear that the person is wearing, or on bedding present on a bed, in a manner that can promote sleep. Bed wear and bedding including such a tactile region is also provided.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to the distal end of the proximal member, the collar member comprising a base portion and one or more ribs connected to the base portion and extending distally away from the base portion. In still some additional embodiments, the guide extension catheter may further include a distal sheath member attached to the collar member, the distal sheath member having a distal diameter larger than the proximal diameter.

Abstract: A catheter is provided comprising localized regions of modified flexibility. The regions of modified flexibility may comprise a softened inner liner, for example softened via stretching the inner liner or disposing a plurality of holes in the inner liner, to modify the bending stiffness and/or tensile stiffness of the catheter. The catheter may further include an axially extending filament that at least partially overlaps the softened portion of the inner liner. The axially extending filament may include an anchoring section to anchor the at least one axially extending filament in a section of the catheter that includes the helical coil.

Abstract: Urinary catheters comprising a tube having an opening at the distal end, and at least one catheter eye that is to be positioned in the bladder, the tube comprising at least one wall region that can be inflated or filled relative to a wall region of the tube. The catheters can be used as permanent catheters that are retained securely in the bladder and completely empty said bladder. The urinary catheter consists of a plurality of layers that are applied in succession and are made of a rubber-like material. The wall region is at least one wall region of the tube, the wall region being at least two mutually separate layers made of the rubber-like material of the wall region. A component of the wall of the tube is at least one channel for inflating or filling or cleaning the wall region, so that the tube is integral.

Abstract: A probe device serves for insertion into a body of a patient. The probe device has a suction conduit between a distal suction feed port and a proximal suction attachment port for the attachment of a vacuum source. Moreover, the probe device has a feed conduit between a proximal feed attachment port, for the attachment of a feed source, and the distal suction feed port. This results in a probe device and a tube/connector assembly, which can be a component thereof, of which the versatility is improved in particular in the area of a medical application or an application in which biocompatibility is important.

Abstract: A connector to secure a winged needle set to a catheter assembly may include a male luer lock. The male luer lock may include a tapered male discharge nozzle and a locking ring surrounding the tapered male discharge nozzle. The locking ring may be internally threaded. The connector may include a septum configured to prevent flow through the tapered male discharge nozzle. The connector may include an arm, which may include a first end, a second end, and a hinge portion disposed between the first end and the second end. The first end may be coupled to the male luer lock. In response to the hinge portion moving from an open position to a closed position, the arm may be configured to secure the winged needle set to the connector.

Abstract: A method for performing an intravascular procedure includes inserting a guide catheter into a blood vessel, and passing a device guide through the guide catheter so that a distal portion of the device guide, having a semi-tubular shape, protrudes from a distal end of the guide catheter into the blood vessel. An intravascular device is inserted through the guide catheter via the distal portion of the device guide to a target site in the blood vessel.

Abstract: An introducer sheath for providing access in a patient's body comprises a tubular body with a distal portion and a proximal portion, the proximal portion being configured to be inserted into the patient's body to allow a medical device to be inserted through the introducer sheath into the patient's body. In order for the introducer sheath to be removable from the patient, it can be separated along its length in a longitudinal direction. The introducer sheath further comprises at least a first handle which is pivotable about a fulcrum. The first handle has a first end portion and a free second end portion so as to form a lever, such that pivoting the handle about the fulcrum causes a contacting portion of the handle to act on a respective counter portion that is operatively connected to the distal portion of the tubular body. This creates a breaking force that causes the distal portion of the tubular body to break.

Abstract: A detector and a method of its use with a guidewire to reduce the incidence of guidewires accidently being left inside patients during the placement of central venous (and other) catheters. In particular, an electronic detector detects whether a catheter has been placed over a guidewire and whether the guidewire has been removed thereafter. In addition, the distance the guidewire has progressed out the patient side of the detector housing which will correspond to the length of guidewire actually inside the patient and any time may be provided.

Abstract: A connector is provided that has multiple electrode rings which are arranged in a row and capable of allowing multiple wires to pass therein The connector also has a relay ring capable of allowing the multiple wires to pass therein. The relay ring has a first mating part fitted to one electrode ring of two adjacent electrode rings and a second mating part fitted to the other electrode ring.

Abstract: In various examples, a method of making a guidewire is described. The method includes placing a polymer jacket over a core wire. The core wire includes a first portion having a first profile and a second portion having a second profile. The first profile is smaller than the second profile. Heat is applied to the polymer jacket and the core wire to reflow the polymer jacket and fuse the polymer jacket to the core wire, wherein the polymer jacket forms a layer of substantially uniform thickness along a length of the core wire. In some examples, a guidewire made using the method is also described.

Abstract: Inflatable medical devices and methods for making and using the same are disclosed. The devices can be medical invasive balloons, such as those used for transcutaneous heart valve implantation, such as balloons used for transcatheter aortic-valve implantation. The balloons can have high strength, fiber-reinforced walls.

Abstract: A multi-purpose balloon intra-cavity catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction opening associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.

Abstract: A medical device (1) for assisting the break-up, disruption or disintegration of calcified or other hardened material within vessels of the human or animal body which material otherwise prevents or inhibits stenting procedures or passage of guidewires, catheters and other devices through the vessels. The device comprises a catheter (2) having a lumen (9) extending between a distal end (5) and a proximal end (6) of the catheter and a displaceable element (4) at the distal end of the catheter configured for axial and/or radial displacement relative to the catheter when driven by pressure fluctuations within the lumen. A pressure pump (11) is coupled to a proximal end of the catheter and is configured for application of a baseline pressure to the catheter lumen. A pressure modulation source (12) is also coupled to the proximal end of the catheter, configured to modulate the baseline pressure in the catheter lumen with one or more pressure impulses, and preferably with a series of pressure pulses.

Abstract: A surgical system and method are used to position a guidewire within an anatomical passageway includes the guidewire, a dilator, a reference feature, and a marker. The guidewire has a guidewire body extending to a distal body end portion. The dilator is secured on the distal body end portion and configured to expand from a contracted state to an expanded state. The dilator in the contracted state is configured to pass through an isthmus of a Eustachian tube. The dilator in the expanded state is configured to dilate the Eustachian tube. The reference feature secured relative to the guidewire, and the marker is positioned on the guidewire a predetermined distance from the reference feature. Thereby, the marker is configured to indicate the predetermined distance to an operator for determining a depth of the reference feature in the anatomical passageway.

Abstract: Described herein are devices for delivering pharmaceutical compositions to individuals in need thereof. Also described herein are methods of using the devices described herein to deliver pharmaceutical compositions to individuals in need thereof.

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with glatiramer or a pharmaceutically acceptable salt thereof, such as glatiramer acetate).

Abstract: The present invention provides a fine hollow protruding tool (1) having a basal member (2) and a fine hollow protrusions (3) project from the basal member (2). The fine hollow protrusions (3) each has an opening portion (3h) on a tip side thereof and an interior in which an interior space linked to the opening portion (3h) is formed. In any vertical cross-section passing through an apex of the fine hollow protrusion (3), a wall thickness (T1) in an apex-side region (TB) on the apex side is thinner than a wall thickness (T2) in a lower-side region (BP) that is closer to the basal member (2) than the apex-side region (TB) is, and a gap (M1c) between inner walls (31) in the apex-side region (TB) is smaller than a gap (M2c) between the inner walls (31) in the lower-side region (BP). A base portion (34) of the fine hollow protrusion (3) projecting from the basal member (2) has a curvature.

Abstract: A microneedle applicator system comprising an applicator and a controller. The applicator comprises an electromechanical actuator arranged in an outer housing to apply a microneedle module via a supporting body onto skin. The electromechanical actuator is arranged to displace the supporting body between a first position inside the outer housing, and a second position substantially in line with an opening in the housing or outside the housing. The controller is arranged to control a velocity of the actuator and/or a pressure force of the actuator by regulating the power that is supplied to the actuator. The controller comprises switching circuitry for switching the power supplied to the actuator on and off, and an integrated circuit arranged to generate a pulse width modulated signal and to control the switching circuitry by setting or adjusting a duty cycle of the pulse width modulated signal.

Abstract: A compact battery and voltage supply controller apparatus for a tattoo machine is disclosed. The battery and controller are configured to connect the battery to the tattoo machine through replaceable internally received magnetic connection adapters. The toggle switch operated display screen provides easy-to-view status and health of the battery and incremental voltage adjustment using a voltage boost circuit and adjustment knob. The internal battery can be replaced and/or removed and recharged.

Abstract: n implantable vascular access port has a main port body with one or more hollow internal chambers formed therein each with a floor at the base of the internal chamber. The port body has an outlet aperture formed in a sidewall there of the internal chamber. One or more parallel, lateral, or angled-access apertures, relative to the port floor and associated septa are located opposite the outlet aperture in the main port body in a sidewall there of (parallel or lateral or angled-access aperture or septum), with at least a one perpendicular-access aperture and septum located opposite the floor of the internal chamber(s). The port chamber in the area of the outlet aperture has an at least partially conical shape directionally aligned with the parallel or lateral or angled-access aperture and septum, with said outlet aperture in contiguity a reversible outlet tube or port body needle locking mechanism.

Abstract: A medical fluid connector, having a first body with a tube section with an inlet and a first thread, a second body with an outlet and a second thread that engages the first thread to move the first and second bodies between closed and opened positions. The second body has a third thread that is configured to rotate in the opposite direction in relation to said first and second threads. The connector has a closure cap with a fourth thread that, in a delivery state of the fluid connector, is detachably screwed to the third thread of the second body, wherein the fluid connector assumes the open position, and wherein the outlet is closed off in an air-permeable and liquid-tight manner by means of the closure cap.

Abstract: An example fixation component for an implantable medical device (IMD) includes a base and a plurality of tines configured be deployed with a target deployment stiffness to engage tissue a target implant site while maintaining a target deflection stiffness after deployment. The base defines a longitudinal axis of the fixation component and is fixedly attached near the distal end of the IMD. Each tine is spaced apart from one another around a perimeter of the distal end of the IMD and extend from the base. A shape of each tine is selected to control each of the target deployment stiffness and target deflection stiffness.

Abstract: Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.

Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.

Abstract: Winding a wire at a first location such that the wire is bunched at the first location, extending the wire from the first location to a second location, winding the wire at the second location such that the wire is bunched at the second location, extending the wire from the second location back towards the first location to a third location proximate the second location, winding the wire at the third location such that the wire is bunched at the third location, extending the wire from the third location back towards the first location to a fourth location at least proximate the first location, winding the wire at the fourth location such that the wire is bunched at the fourth location, severing the wire at one or more locations, and forming an electrode assembly utilizing the windings.

Abstract: An implantable cuff electrode and/or optrode (40) adapted to encircle a substantially cylindrical tissue (70), is provided that includes a support sheet (43) rolled about a longitudinal axis, forming a cuff of inner diameter, Dc, and extending over a length, L a central portion, extending over a length, lc, of at least 50% of the length, L, and having a mean central thickness, tc, and wherein the central portion is flanked on either side by, a first edge portion (43e) of mean edge thickness, te1, and a second edge portion (43e) of mean edge thickness, te2, at least a first electrode contact or a first optrode exposed at an inner surface of the cuff, and remote from an outer surface forming the exterior of the cuff, Characterized in that, the mean edge thicknesses, te1, te2, of the first and second edge portions are each lower than the mean central thickness, tc,

Abstract: A bioelectric interface is provided. The bioelectric interface comprises a case having a channel configured to hold a nerve. An electrode array is slidably coupled to the case, wherein the electrode array comprises a number of electrode shanks. The case restricts movement of the electrode array to one degree of freedom toward or away from the nerve held in the channel for insertion of the electrode shanks into the nerve.

Abstract: A medical apparatus for a patient comprises an external system and an implantable system. The external system is configured to transmit one or more transmission signals, each transmission signal comprising at least power or data. The implantable system is configured to receive the one or more transmission signals from the external system, and to deliver stimulation energy to the patient. Methods of delivering stimulation energy are also provided.

Abstract: An implantable medical device delivery system includes a delivery catheter including an elongated body with a first portion defining a first lumen and a second portion defining a second lumen. An angle is defined between a first axis and a second axis defined by the first and second portions, respectively. The second axis points toward the left ventricular (LV) apex of the patient's heart when the first axis points into the CS. The first portion or an elongated element may extend into the CS to anchor the delivery catheter to the orientation of the CS.

Abstract: A leadless pacing device may include a housing having a proximal end and a distal end, and one or more electrodes supported by the housing. The housing may include a body portion and a header. A distal extension may extend distally from the header of the housing, the distal extension including one or more electrodes. The header may include a guide wire port and a guide wire lumen may extend from the guide wire port through the header of the housing and through the distal extension. A fixation member may extend from the header of the housing. The header may be formed from an over mold process.

Abstract: Methods of reducing the viability of cancer cells, preventing cancer cells of a subject from developing resistance to TTFields, and restoring sensitivity of cancer cells to TTFields by recommending or prescribing a PTGER3 inhibitor to a subject and applying an alternating electric field to the cancer cells are provided. In some instances, sensitivity of cancer cells to TTFields can be restored with one or more PTGER3 inhibitors (e.g., NSAIDs, cox2 inhibitors).