Abstract: Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method includes applying a plurality of laser pulses to the IOL. The laser pulses can be configured to produce, by refractive index writing on the IOL, a predetermined change in phase profile of the IOL to increase spectacle independence.

Abstract: Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method includes determining at least one photic phenomenon experienced by the subject after implantation of the IOL; and applying a plurality of laser pulses to the IOL, the laser pulses being configured to produce, by refractive index writing on the IOL, a phase shift in the IOL to compensate for the photic phenomenon.

Abstract: Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method of treating an ocular disease of a subject having an implanted intraocular lens (IOL) includes determining visual needs of a subject that are associated with an ocular disease of the subject determining a pattern of a plurality of pulses of radiation to apply, by refractive index writing, and applying the plurality of pulses of radiation to the one or more selected areas of the IOL.

Abstract: Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method includes vergence matching for an intraocular lens (IOL) having an optical profile induced by refractive index writing.

Abstract: Hybrid Accommodating Intra Ocular Lens (AIOL) assemblages including two discrete component parts in the form of a discrete base member for initial implantation in a vacated capsular bag and a discrete lens unit for subsequent implantation in the vacated capsular bag for anchoring to the discrete base member. The lens unit includes a lens optics having at least two lens haptics radially outwardly extending therefrom. The base member includes a flat circular base member centerpiece having zero optical power.

Abstract: A capsular tension ring inserter (10) and method includes a cannula (54) adapted to house a capsular tension ring (CTR) (26) having a leading eyelet (32), a hook element (56) disposed within the cannula (54) that engages and moves the CTR (26) during deployment, and a suture (28) placed on the leading eyelet (32) and fed back through the cannula (54) to allow a user to control insertion of tile CTR (26) into a capsular bag (42) of an eye (40) by pulling on the suture (28) during insertion of the CTR (26).

Abstract: An implantable prosthetic device includes a plurality of anchor members, a plurality of clasps, and a cover. The plurality of clasps are configured to capture the leaflets to secure the leaflets to the anchor members. The cover is disposed over the plurality of anchor members. The cover can also be disposed over the clasps and a spacer member. A portion of the cover can be covered by a coupler. One or more extensions of a coupling collar can extend through the cover.

Abstract: A method of treating a native mitral valve without open-heart surgery is disclosed. An expandable prosthesis includes an anchoring portion and an occluding member coupled to the anchoring portion. The prosthesis is loaded into a distal end portion of a delivery catheter and is advanced through a femoral vein and through a pre-made puncture in an atrial septum. The anchoring portion self-expands within the left atrium for anchoring the occluding member in a fixed position. The anchoring portion is preferably a laser cut structure that conforms to the left atrium and uniformly distributes anchoring forces within the left atrium. After deployment, the occluding member prevents blood from flowing from the left ventricle to the left atrium during systole. The occluding member is preferably made from a flexible material, such as pericardial tissue.

Abstract: In a surgical method for improving cardiac function, an implantable scaffold or valve support device is inserted inside a patient's heart and attached to the heart in a region adjacent to a natural mitral or other heart valve. The scaffold or valve support device defines an orifice and, after the attaching of the scaffold or valve support device to the heart, or temporary support while native valve leaflets and/or subvalvular structures are captured, a prosthetic or bio-prosthetic valve seated in the orifice, and the native valve may be retracted into the scaffold/replacement assembly to create a gasket for sealing the complex.

Abstract: A method is provided, including (1) identifying the subject as having mitral valve regurgitation; (2) during a medical procedure, in response to identifying the subject as having mitral valve regurgitation, implanting a prosthetic valve at a mitral valve site of the heart; and (3) during the same medical procedure, implanting a therapeutic septal device at a septum of the heart. Other embodiments are also described.

Abstract: A transcatheter valve prosthesis includes a stent, a prosthetic valve component disposed within and secured to the stent, and a sealing component. The sealing component includes a donut-shaped component and at least one pulling suture extending between the donut-shaped component and the stent. The at least one pulling suture is coupled to the stent such that the pulling suture can slide relative to the stent when the stent radially expands from the compressed configuration to the expanded configuration. The sealing component has a delivery configuration in which the donut-shaped component is disposed proximal of a proximal end of the stent and a deployed configuration in which the donut-shaped component is disposed distal of the proximal end of the stent. The pulling suture is configured to longitudinally pull the donut-shaped component as the stent radially expands from the compressed configuration to the expanded configuration.

Abstract: A transcatheter prosthesis with radially compressed and expanded configurations. An elongate member encircling at least a portion of the prosthesis, and configured to provide a seal between the prosthesis and a native anatomy when the prosthesis is deployed in the radially expanded configuration. The elongate member may be a resilient elongate member having a radially contracted state, when in tension, to hold at least the portion of the prosthesis in the radially compressed configuration, and having a radially expanded state, when relaxed, to provide the seal between at least the portion of the prosthesis and a native anatomy when the prosthesis is deployed. A system for delivering the transcatheter prosthesis may include a delivery catheter having an elongate cinching member encircling at least a second portion of the prosthesis, wherein the elongate cinching member is configured to hold the second portion of the prosthesis in the radially compressed configuration.

Abstract: An implantable prosthetic valve includes a radially collapsible and radially expandable annular frame. The frame includes an annular main body sized to be implanted within a native mitral valve annulus. The frame also includes an atrial sealing member coupled to and extending radially away from the main body. The atrial sealing member is sized to extend over tissue of the native mitral annulus within a left atrium to reduce paravalvular leakage. The atrial sealing member includes an inner zig-zag portion and an outer zig-zag portion. The inner zig-zag portion and the outer zig-zag portion are connected to the main body portion only via a fabric to enhance flexibility of the atrial sealing member relative to the main body. The prosthetic valve also includes a valve member disposed within an interior of the frame.

Abstract: A prosthetic heart valve includes a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end and an aortic section adjacent the distal end. The heart valve further includes a plurality of commissure features disposed on the stent, and a collapsible and expandable valve assembly, the valve assembly including a plurality of leaflets connected to the plurality of commissure features, each of the plurality of leaflets having a free edge and being configured to have a tension line aligned near the free edge to prevent backflow.

Abstract: Described is a prosthetic valve, comprising: an expandable stent including an inner lumen and having a first and a second end; and a spring attached to the first end of the expandable stent; wherein the expandable stent and the spring can expand radially to a desired diametric configuration in order to anchor the prosthetic valve at an implantation position in a body lumen. Related systems and methods.

Abstract: Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within ajar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly.

Abstract: An easy-to-control interventional instrument delivery device, comprising a core tube (7), a guiding head (2) and a fixing head (3) being fixed onto the core tube (7); the guiding head (2) is fixed at a distal end of the core tube (7), and the fixing head (3) extends from a proximal end side of the core tube (7), an interventional instrument mounting position being located between the guiding head (2) and the fixing head (3); the outer periphery of the interventional instrument mounting position is provided with an axially slidable outer sheathing tube (5), further being provided with a floating limiting strip (1); a proximal end of the floating limiting strip (1) is a starting end (13) that is connected near the fixed head (3), and a distal end is a terminal end (11, 101) that floats between the interventional instrument mounting position and the outer sheathing tube (5).

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve configured to transition between radially compressed and radially expanded configurations may be provided. The prosthetic heart valve may include an outer frame, an inner frame, and at least one tissue anchor extending from at least one of the frames. The prosthetic heart valve may be configured to maintain a first distance between the downstream ends of the inner and outer frames when the prosthetic heart valve is in the radially compressed configuration and a second distance between the downstream ends of the inner and outer frames when the prosthetic heart valve is in the radially expanded configuration, the first distance being greater than the second distance.

Abstract: A method of treating a heart of a patient is provided. The method includes implanting a first tissue anchor in cardiac tissue of the patient and a second tissue anchor in the patient, such that the first and the second tissue anchors are coupled together by one or more tethers. Thereafter, after allowing at least 24 hours for tissue growth on the first tissue anchor to strengthen anchoring of the first tissue anchor in the cardiac tissue, tension is applied between the first and the second tissue anchors using at least a longitudinal portion of the one or more tethers. Other embodiments are also described.

Abstract: A male prosthesis applicable for treating male sexual dysfunction. The prosthesis includes a restraining/strengthening region operable to behave similar to a suspensory ligament in the human body.

Abstract: An extended release immunomodulatory implant operatively arranged to facilitate bone morphogenesis, including an inner portion including one or more interleukins, and an outer portion including an immunomodulatory stimulant such as an antigen.

Abstract: An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.

Abstract: Anti-biofilm osseointegrating implantable devices are made by additive manufacturing. A powder formulation is made that includes a resin such as a polyarylether ketone such as PEEK, and a zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The powder formulation also may include a porogen to control the porosity of the resulting three-dimensional implant device. The devices, which are osseointegrating, may include metal-loaded zeolite so as to elute antimicrobial metal ions in a therapeutically effective amount when implanted into a body and exposed to bodily fluid.

Abstract: The present disclosure sets forth a system and method for forming sheets of material, such as titanium mesh or plates, for surgical applications prior to surgery. The disclosed solutions provide this capability without incurring expense from use of PEEK or PEKK by manufacturing contoured plates based on a shape of an anatomical structure in a 3D image, such as a pre-defect MRI. The contoured plates are used to stamp the titanium mesh, plate, or other sheet of material into the shape of the bone prior to the defect. In some aspects, the mesh or other material layer can also be trimmed prior to surgery using, for example, a reproduction of the anatomical structure manufactured from a post-defect MRI of the same anatomical structure.

Abstract: A device implantable in a human body comprising a first component, or main support component, delimiting a plurality of openings, and a second component disposed on a surface of the main support component.

Abstract: A liner adapted for insertion into an acetabular shell for use in hip arthroplasty. The liner includes a concave inner surface adapted to engage a femoral head. The liner also includes an outer surface adapted to engage the acetabular shell and a rim that extends between the inner surface and the outer surface. The outer surface includes a locking section extending from the rim, a composite-curved section extending from the locking section at a first transition point, and a dome section extending from the composite-curved section, wherein at the first transition point, the composite-curved section is tangential to the locking section.

Abstract: A hinge knee system includes a tibial assembly having a baseplate component and an axle component. The baseplate component has an opening that extends therein from a proximal end toward a distal end thereof. The axle component has a shaft portion receivable within the opening of the baseplate component and an axle connected to the shaft portion that extends in a direction transverse to a longitudinal axis of the shaft portion. The system also includes a femoral assembly that includes a distal femoral component. The distal femoral component includes condylar portions and an intercondylar portion disposed between the condylar portions. The intercondylar portion includes a bearing surface that defines a recess configured to rotatably receive the axle for articulation therewith.

Abstract: A stemless implant for shoulder arthroplasty includes a body having a proximal portion, distal portion, and an outer surface. A cylindrical extrusion is substantially perpendicular to and adjacent the proximal portion. At least a portion of the outer surface is configured to contact bone, the outer bone contacting surface comprising a concave taper. The stemless implant can be sized and shaped for insertion into a metaphysis of a humerus bone without penetrating a diaphysis of the humerus bone. The implant optionally comprises a medial fin, a lateral fin, an anterior fin, and a posterior fin. The medial fin and lateral fin may be thicker than the anterior fin. The fins may taper from the proximal portion to the distal portion.

Abstract: A stemmed implant comprises a proximal body with a distal shaft extending from the proximal body. The proximal body exterior may be spherical, conical, cylindrical, or another surface of revolution. The distal shaft comprises multiple longitudinal ridges which may originate from the proximal body as separate columns, or which may merge together. The distal shaft and/or the ridges may become narrower as they extend away from the proximal body.

Abstract: This augment insert (200), comprises a coupling member (204) for securing the augment insert to a glenoid component (103) of a shoulder prosthesis (101), and a body (202), comprising a first side (206), configured to bear against a scapular side (107) of the glenoid component when the augment insert is secured to the glenoid component by means of the coupling member; and a second side, opposed to the first side and configured to bear against or be adjacent to a scapula of a patient. According to the invention, the body (202) comprises at least one breakable portion (230), extending from the first side (206) to the second side and configured to be broken off the body. The aperture (234) is provided for accommodating an engaging member (111) of the glenoid component (103), said engaging member protruding from a scapular surface (127) of the scapular side (107) of the glenoid component (103) and being configured for securing the shoulder prosthesis to the scapula.

Abstract: A flexible bone implant includes a proximal stem having a proximal end, a distal end, and a proximal conduit extending from the proximal end to the distal end of the proximal stem, whereby the proximal conduit is open at both the proximal and distal ends of the proximal stem. The implant includes a distal stem having a proximal end, a distal end, and a distal conduit extending from the proximal end to the distal end of the distal stem, whereby the distal conduit is open at both the proximal and distal ends of the distal stem. The implant includes a flexible hinge interconnecting the distal end of the proximal stem with the proximal end of the distal stem for allowing the proximal and distal stems to flex relative to one another.

Abstract: The present disclosure relates to an anti-rotation locking system for an expandable implant. The anti-rotation locking system may include a screw comprising a screw head comprising a plurality of notches. The anti-rotation locking system further comprises a housing and a locking member comprising a ring, a partial ring, and a strut coupling the ring to the partial ring.

Abstract: A surgical implant includes a body portion, a first tier, and a second tier. The first tier is attached to an upper surface of the body portion, and the second tier is attached to a lower surface of the body portion. Each of the upper surface and the lower surface of the body portion includes channels formed therein. The first tier includes a first layer including a plurality of first slats and a second layer including a plurality of second slats, where the plurality of first slats and the plurality of second slats intersect one another to form openings therebetween. The second tier includes a third layer including a plurality of third slats and a fourth layer including a plurality of fourth slats, where the plurality of third slats and the plurality of fourth slats intersect one another to form openings therebetween.

Abstract: A surgical implant and a method for the making the surgical implant is provided. The surgical implant includes various granules incorporated into an upper surface and a lower surface of a body portion thereof. The granules can be pressed into the upper surface and the lower surface via physical force using at least one mold portion. The physical force applied by the at least one mold portion can deform and/or extrude the upper surface and the lower surface to impregnate these surfaces with the granules. The granules can provide the implant with bioresorbable and/or mechanically-reinforced properties.

Abstract: An instrument and inserter kit for providing a load to insert or retract an implant 2000 is provided. The instrument includes a cover having an engagement end opposite a distal end. The engagement end is configured to mount to an engagement feature of a handle of an inserter. The cover is an elongated member having a C-shaped profile having a dimension configured to receive a sliding member. The sliding member is seated over the cover and is weighted. The sliding member is configured to slide between a first radial lip and a second radial lip so as to provide an impacting force or retracting force on the instrument.

Abstract: An implant insertion instrument, and an implant are provided. The instrument includes a handle, a sleeve mounted to a distal end of the handle, and an implant rod disposed within the sleeve. The implant rod includes a gripper disposed on a distal end of the implant rod. The gripper has a first prong spaced apart from a second prong, the second prong being longer than the first prong. The implant includes an implant body, the implant body having a convex surface opposite a concave surface wherein an outer surface of the implant is continuous so as to prevent bone growth within the implant. Accordingly, the instrument facilitates the engagement of the implant by a simple push of the sleeve. Further, the implant has a continuous surface so as to inhibit bone growth and facilitate removal of the implant from the surgical site.

Abstract: Spinal implant trials are provided having various configurations and sizes that aid the selection of spinal implants having similar configurations and sizes. A surgeon during surgery can insert various configurations and sizes of the spinal implant trials into a disc space between two adjacent vertebral bodies of a patient to enable the selection of a spinal implant configured and sized to fit the patient's disc space. Fluoroscopic images can be used in aiding the selection of an appropriately configured and sized spinal implant corresponding to one of the spinal implant trials. The spinal implant trials include features that reveal on the fluoroscopic images whether the spinal implant trials are properly oriented and positioned in the disc space. As such, the selection of the configuration and size of the spinal implants can be made after it is determined that the spinal implant trials are properly oriented and positioned within the disc space.

Abstract: A device for fixing two orthopedic components to one another includes a receiving element arranged on a first orthopedic component, which receiving element has a receptacle and includes a connecting element arranged on a second orthopedic component. The connecting element has a connector. The connector can be inserted into the receptacle and is coupled with the receiving element in a tensile force, compressive force, and torque-transmitting manner. At least one flow- and/or data-transmitting contact is arranged on the connecting element and the receiving element so as to correspond to one another, which form an electrical and/or data-transmitting connection with one another in a fixed state of the orthopedic components.

Abstract: The synergetic prosthetic system comprises of a knee and an ankle sleeve on the functional leg and a prosthesis on the amputated leg. Each sleeve comprises of a power supply, an accelerometer, a wireless transmitter and a wire connecting the accelerometer to the wireless transmitter. The prosthesis comprises of a power supply, a microcontroller, servo motors, a knee joint assembly, and an ankle joint assembly. A steel rod covered with a casing connects the knee and ankle joints. The accelerometer measures and transmits the angle of rotation of the functional knee and ankle joint to a microcontroller. The microcontroller pre-programmed with normal gait data pairs the data from the healthy leg and controls the servo motors. The servo motors, move the prosthetic joints to mimic a normal human gait.

Abstract: A passive upper extremity prosthesis for enabling a user with a residual arm to play a cue sport includes a socket that is configured to position over and to couple to a residual arm of a user. A connector that is coupled to the socket is configured to selectively couple to a cue stick to couple the socket to the cue stick, positioning the user to manipulate the cue stick to play a cue sport, such as pool and billiards.

Abstract: A vascular shunt frame with improved apposition including a main body tube; at least one end of the main body tube is provided with a sealing covering; the sealing covering is provided with a main blood flow opening; a shaping component is disposed at the edge of the main blood flow opening. When the main body stent is inserted into the main blood flow opening of the main body tube, the shaping component can be closely attached to the outer surface of the main body stent, such that the sealing covering closely fits the outer surface of the main body stent to prevent endoleaks. The present disclosure also provides a vascular stent provided with an apposition-improved vascular shunt frame.

Abstract: A stent having an improved anti-sliding function is proposed. The stent includes inner and outer stents that have undergone heat treatment and have several spaces formed by weaving or crossing wires made of a superelastic shape memory alloy in a hollow cylindrical net shape, in which the outer stent is shorter than the inner stent and has an enlarged section having a diameter larger than the inner stent and a bending section formed by bending inward a side of the enlarged section; and a pair of outer stents are fitted on both ends of the inner stent such that a pair of enlarged section face each other, and spaces of the inner stent and spaces of the bending sections are connected by a connection thread, whereby a space section is defined between the inner stent and the outer stent.

Abstract: A double-layer blood vessel stent. A skirt-sided stent is provided on a main body stent. A first developing member and a second developing member are provided on the main body stent. The first developing member includes a first developing portion and a second developing portion, where the first developing portion and the second developing portion are flush with a free end at a position where the distance between the intersections on a plane perpendicular to the direction of an axis of the main body stent is the minimum distance; and an end, away from a first end, of the second developing member is flush with an end away from a tapered section of an extending section. This structure allows for accurate positioning of the double-layer vessel stent.

Abstract: An implantable biocompatible expander suitable for implantation into a urinary duct, comprises an elongated sinusoidal ring comprising at least two proximal prongs and at least two distal prongs, wherein the expander is resiliently deformable from a relaxed radially expanded orientation to a radially contracted orientation suitable for transluminal delivery through the urinary duct. The expander is configured to exert an outward radial force against a wall of the urinary duct when in-situ within the urinary duct. In particular, the expander is suitable for treatment of benign prostatic hyperplasia and configured for implantation into the prostatic urethra between, and substantially spanning the prostatic urethra between, the bladder neck and external sphincter.

Abstract: A prosthesis is disclosed for placement across an ostium opening from a main body lumen to a branch body lumen. The prosthesis has a radially expansible support and a bifurcation traversing portion. The radially expansible support is configured to be deployed in at least a portion of the branch body lumen. The bifurcation traversing portion has a biostable portion having a first end and a second end. The first end is located adjacent to the radially expansible support. The bifurcation traversing portion also has a biodegradable portion having a first end coupled with the second end of the biostable portion. The biodegradable portion has a second end disposed at an end of the prosthesis opposite the radially expansible support. When deployed, the bifurcation traversing portion extends from the radially expansible support across a bifurcation and into a main body lumen such that the carina is supported thereby.

Abstract: An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40).

Abstract: One preferred embodiment includes a stent delivery system including a retractable sheath and an outer stability sheath. The stability sheath freely rotates relative to the retractable sheath, relieving compression forces caused by twisting of stability sheath in when in a tortuous conformation.

Abstract: A delivery device can include several different features including, at least: a shuttle and trigger retraction of an outer sheath; an interlock device to prevent actuation of the trigger; a retraction override switch and lock; and an inner shaft adjuster to ensure correct alignment of the inner shaft and the outer sheath prior to device deployment. The inner shaft adjuster may include, at least: a proximal portion of the handle housing having slots therethrough: pins operatively fixed to the inner shaft and extending through and slidable within the slots: and a cap having an inner helical groove that mates with the pins. Rotation of the cap may push the pins and the inner shaft in a proximal-distal direction. The cap may have a distal lip configured to accept a proximal extension of the interlock and retain it in a locked position until the inner shaft has been adjusted or moved.

Abstract: Disclosed is a method, apparatus, and kit for assisting the expansion of a self-expanding stent, especially within highly curved or tortuous blood vessels. An elongated pusher having an expandable distal mesh portion can be positioned within a self-expanding stent, expanding during delivery to provide extra expansion force to the stent to ensure the stent properly expands.

Abstract: A method is provided for inducing weight loss in a subject. The method includes using an energy source, applying energy to thalamic nuclei of a subject, modifying at least a portion of the thalamic nuclei by applying the energy, and inducing weight loss in the subject.