Abstract: An imaging endoscopy system is disclosed, having a base unit, a hand controller, an umbilical section releasably connecting the base unit and the hand controller and an insertion section. The insertion section has a proximal end connected to the hand controller and a distal end for insertion into a subject, the distal end having a steering section and a distal tip. The hand controller includes at least one steering control for controlling bending of the steering section, and wherein the distal tip includes a light source for illumination of a region of tissue of interest and an imaging chip for imaging the region of tissue of interest. The hand controller, umbilical section and insertion section are single use disposable. The base unit is configured to be re-usable.

Abstract: A direct intracardiac imaging catheter capable of entering chambers of the heart and providing an image through a vein or an artery percutaneously, or through direct access during open surgery. The intracardiac imaging catheter apparatus is a small optical fiber imaging system. The catheter is deflectable and capable of navigating within all heart chambers to acquire detailed images, and adjacent large vessels during percutaneous cardiac procedures. The catheter can access the arterial system to acquire blood vessel images. It can pass through the intra-atrial septum (foramen ovale) for cardiac procedures in the left chambers and large vessels adjacent the left heart, including pulmonary veins and the aorta. During open heart surgery, images can be provided from hard to access regions including the back of the heart during off pump cardiac surgery. The apparatus includes balloon tip that can be inflated and deflected based the movement of catheter.

Abstract: The present disclosure provides systems and methods for medical imaging. The system may comprise an optical adapter. The optical adapter may comprise a housing that comprises (1) a first end configured to releasably couple to a scope and (2) a second end configured to releasably couple to a camera. The optical adapter may comprise an image sensor coupled to the housing. The optical adapter may comprise an optics assembly disposed in the housing. The optics assembly may be configured to (1) receive light signals that are reflected from a target site within a subject's body and transmitted through the scope, and (2) reflect a first portion of the light signals onto the image sensor while permitting a second portion of the light signals to pass through to the camera.

Abstract: The present invention relates to a cover having a plurality of moveable, external, angled projecting elements for use with flexible medical scoping devices such as endoscopes or enteroscopes. The invention includes the cover with an over cuff and use of the disposable removable covering in methods of medical scoping procedures or examinations. The invention also includes an applicator for assisting in placing the covering about or over a medical device and a kit of parts.

Abstract: Apparatuses, including sleeves, intraoral scanning systems to use these sleeves, and methods of using the sleeve, that authenticate the sleeve for use with an intraoral scanning system. Authentication may include verifying that the sleeve is new (unused) and/or verifying that the sleeve is appropriate and/or intended for use with the intraoral scanning system. Once authenticated, operation parameters of the intraoral scanning system can be automatically set based on information from a scanned identifier on the sleeve.

Abstract: Disclosed is an endoscope system comprising an endoscope having at its distal end at least one front-facing camera and multiple side-facing cameras, with each of the front-facing and side-facing cameras capturing a corresponding participating sub-view. The endoscope system further comprises an image display device adapted to receive the corresponding participating sub-views, and integrate and combine the corresponding participating sub-views to form a combination panoramic view covering or substantially covering a vicinity of 360-degree or substantially 360-degree surrounding the distal end.

Abstract: An articulating working channel system for use with a plurality of flexible tools which are adapted to be interleaved in a single surgical procedure, comprising: a working channel subassembly including a hollow flexible shaft; and a surgical tool subassembly including the flexible tool, wherein the flexible tool includes a flexible tube which is adapted to be inserted into the flexible shaft and wherein the flexible shaft is adapted to be articulated and the flexible tube is adapted to be passively articulated therewith.

Abstract: A treatment device includes a flexible sheath; a control wire that can move axially within the flexible sheath; a first treatment member connected to a distal end of the control wire; a second treatment member connected to a distal end of the first treatment member; and a protection member that covers the second treatment member depending on the mode of operation. When the treatment device is in a first treatment mode, the second treatment member projects from a distal end of the protection member. When the treatment device is in a second treatment mode, the first treatment member projects from the distal end of the flexible sheath, and the protection member covers the second treatment member.

Abstract: A capsule endoscope image receiver includes a receiving electrode unit that receives first and second differential signals from a capsule endoscope image transmitter through a human body communication channel, an analog amplifying unit that receives the first and second differential signals and outputs first and second amplified differential signals, and a signal restoring unit that receives the first and second amplified differential signals and restores image information. The analog amplifying unit includes a first amplifier that outputs the first amplified differential signal, a second amplifier that outputs the second amplified differential signal, and an input impedance that is connected between a first inverting input terminal of the first amplifier and a second inverting input terminal of the second amplifier and obtains a gain of differential signal amplification in which a high frequency component of the first and second amplified differential signals is greater than a low frequency component.

Abstract: An endoscope system includes a processor configured to generate a clock at predetermined timing, a light source apparatus configured to irradiate white light and excitation light in a time division manner in synchronization with the clock, and an endoscope configured to perform image pickup based on irradiation timing of the light source apparatus. The processor generates a first white light image at a first clock, generates a first fluorescent image at a second clock, generates a second white light image at a third clock, and generates a third white light image at a fourth clock and superimposes the second white light image and the first fluorescent image at the fourth clock and superimposes the third white light image and the first fluorescent image at a fifth clock.

Abstract: In some embodiments, endoscopy systems and/or methods of using endoscopy systems are described. In some embodiments, an endoscopy system comprises a shaft having an image sensor within a distal tip of the shaft. The shaft can have an expandable cuff disposed on an outer surface of the shaft. The expandable cuff can be moved from a contracted configuration to a deployed configuration. In the deployed configuration, an outer surface of the expandable cuff can inhibit, reduce, or prevent fluid (e.g., blood) flow in the vessel. Inhibiting or preventing the fluid flow can permit direct visualization of the interior of the vessel by the image sensor without interference from the fluid.

Abstract: A lighting module includes a housing portion, a clip portion having a receiving space between configured to receive a speculum, an arm portion extending from the clip portion and including a lighting element, and a power source electrically connected to the lighting element. Also, a speculum assembly including a speculum and a lighting module is disclosed. Finally, a method of using a lighting module is disclosed.

Abstract: An otoscope includes an instrument head, a tip element and an optical system. The instrument head has a distal insertion portion for insertion into an ear of a human or veterinary subject. The distal insertion portion has a distal opening. The tip element is releasably attached to the distal insertion portion. The tip element has a distal opening. The optical system is contained within the instrument head. The optical system includes a plurality of optical components. The optical system further comprises a viewing component for viewing of an image of a target of interest aligned along an optical axis disposed within said distal opening. The optical system is configured to provide a field of having a diameter equaling at least 7 mm at a distance of at least 15 mm from a distal opening of said attached tip element. The optical system is further configured to simultaneously provide a distance range of optimal focus having a range of at least 8 mm.

Abstract: A laryngoscope system including a laryngoscope device and a blade assembly. The laryngoscope device has a handle member and a front-end member, which includes: a longitudinal member, with a channel, being connected with the handle member; a sliding part having at a distal end an imaging and/or a lighting device and being configured to be at least partially inserted in and movable along the channel, which has an abutment and a positioning spring between the abutment and a proximal end of the sliding part. The blade assembly is configured to cooperate with the front-end member and has fixed to one another: a blade having a distal tip; an insertion housing, which has a cavity to receive the front-end member, includes an engaging element having an edge to cooperate with the longitudinal member's distal end, the engaging element's edge being positioned at a predefined distance from the blade's distal tip.

Abstract: A colposcope includes an inserter including an elongated body defining an interior space and an image capture device configured to be selectively and slidably positioned within the interior space of the elongated body. The elongated body has a distal end portion and a proximal end portion. The distal end portion is substantially funnel shaped and has a distal end that includes first and second portions. The first portion includes a base at a first edge of the distal end, and the second portion includes a lip at a second edge of the distal end that is diametrically opposed from the first edge. The lip is positioned further from the proximal end portion than the base.

Abstract: Provided herein is a bendable ureteral access sheath comprising: (i) a sheath tube comprising a first straight tube section at the tail end, a bendable tube section in the middle, a second straight tube section at the front end of the sheath tube, and a sheath tube hub attached to the tail end of the sheath tube; and (ii) an inner tube having an inner tube knob attached to the tail end of the inner tube; wherein the sheath tube is sleeved on the outside of the inner tube.

Abstract: Provided are a method and a device for evaluating a tear fluid to objectively evaluate and determine the severity of dry eye or the like. Color information is acquired in a predetermined region of a tear fluid interference fringe image, a numerical value representing a color diversity is calculated from the color information acquired, and the numerical value representing the color diversity thus calculated is used as an index for evaluating a tear fluid state.

Abstract: Optical coherence tomography (OCT) imaging systems, handhold probes, and methods that use a field curvature to match a curved surface of tissue are disclosed. According to an aspect, an OCT imaging system includes optical elements to generate diverging light. The system also includes one or more mirrors and a lens system configured to scan the diverging light onto a curved surface of an object for imaging of the object.

Abstract: Method for determining a refraction of at least an eye of a person under specific spectral conditions, the method including: an eye illumination step, during which the eye of the person is illuminated under the specific spectral conditions, the specific spectral conditions being provided by a polychromatic source having a spectrum which is different from the spectrum of a white light source and/or by a chromatic filter positioned before the eye of the person and illuminated by a source; and a refraction determination step during which the refraction of the eye of the person is determined under the specific spectral conditions.

Abstract: The invention relates to a device for the determination and analysis of the motor skill and the oculomotor skill of a person (100), with a headset comprising at least the following components: a display unit (9) for displaying an image to the eyes of a person (100), when the headset is mounted on the head of the person (100); an optical sensor system (3, 4, 6) for estimating the position and shape of an object in three-dimensional space and for estimating the position of the head set in three dimensional space, wherein the optical sensor system (3, 4, 6) is arranged and designed for the detection and registration of the hands and fingers of the person (100); an eye-tracking module (8) that is configured to determine a point of gaze of the person (100) wearing the device. The invention furthermore relates to various methods for using the device.

Abstract: A system for measuring eye tracking may include a chassis, which may include a main column and a head rest assembly. The head rest assembly may include a stimulus screen for displaying a video to the patient, an optical mirror, an eye tracking camera, and at least one head rest member for stabilizing the patient's head, relative to the stimulus screen. The system may also include: a base attached to a bottom of the main column to support the main column; an arm extending from the main column to support the head rest assembly; a touchscreen interface attached to the main column and configured to provide control of the system to a user; a camera computer housed in the main column for controlling the eye tracking camera; and a system computer housed in the main column for controlling the stimulus screen, data processing and other functions.

Abstract: Systems and methods for imaging an eye are disclosed. The systems and methods may include at least one plenoptic camera. The systems and methods may include an illumination source with a plurality of lights.

Abstract: A method of automating the collection, association, and coordination of multiple medical data sources using a coordinating service application, computer, database, and/or server system to manage devices, examinations, and people involved in the medical examination and treatment process. In an embodiment, the method comprises authenticating a user for a premises, a device, or a device group, validating particular use of the device based on user credentials or type of device or device group, associating a medical examination with a patient or a medical examination schedule, associating medical examination data from a device or device group with a related medical examination session, routing medical examination data to a computer, database, or server, and pairing medical examination session data with a medical interpretation, clinical testing results, diagnoses, and/or other recorded information.

Abstract: The present invention is directed to a medical imaging binocular indirect ophthalmoscope with onboard sensor array and computational processing unit, enabling simultaneous or time-delayed viewing and collaborative review of photographs or videos from an eye examination. The invention also claims a method for photographing and integrating information associated with the images, videos, or other data generated from the eye examination.

Abstract: A cardiac device includes an electrocardiograph (ECG device) (10, 110), an electronic processor (12, 36), and a non-transitory storage medium (14, 38) storing instructions readable and executable by the electronic processor to perform a process including: receiving a location of the ECG device; tuning one or more ECG diagnostic criteria for the received location to generate one or more ECG analysis criteria tuned for the received location; operating the ECG device to acquire one or more ECG traces; and performing cardiac analysis by applying the one or more ECG analysis criteria tuned for the received location to the one or more ECG traces to generate cardiac analysis information. The tuning may include associating the ECG device with a medical department based on the location and tuning the one or more ECG analysis criteria for the associated medical department. Alternatively, the associated medical department may be received directly.

Abstract: A system for processing a medical image for personalized brain disease diagnosis and status determination, includes: an image processing unit, which obtains a 3D T1 weighted image, a 2D T2 fluid attenuated inversion recovery (FLAIR) image, a magnetic resonance angiogram (MRA) image, which images only a vessel for checking abnormality of a brain vessel, and a 4D phase-contrast flow image for recognizing a state of a blood flow in a vessel; a complex image analyzing unit, which selects a disease-to-be-diagnosed, sets a brain area according to the selected disease, and analyzes brain tissue and a brain vessel; and a personalized diagnosis and result output unit, which outputs a brain state, a disease-specific risk degree, a risk of disease, and a disease prediction result through a machine learning algorithm by utilizing an age-specific data DB.

Abstract: The invention is directed to methods for diagnosing reperfusion/non-reperfusion hemorrhage and predicting cardiac arrhythmias and sudden cardiac death in subjects comprising using imaging techniques to detect regional iron oxide deposition. The invention also provides treatment methods for subject at increased risk of sudden cardiac death.

Abstract: A wireless patient monitoring device can be fully functional stand-alone patient monitoring device capable of various physiological measurements. The patient monitoring device is small and light enough to be comfortably worn on the patient, such as on the patient's wrist or around the neck. The patient monitoring device can have a monitor instrument removably engaging a disposable base. The base can have outlets for connecting to an acoustic respiration sensor and an oximeter sensor. The patient monitoring device can have pogo pin connectors connecting the monitor instrument and the disposable base so that the monitor instrument can receive sensor data from the sensors connected to the disposable base.

Abstract: The present invention relates to a method of disinfecting a region, in particular a skin region of a patient, wherein the method comprises the following steps: a) Application of an optically effective substance to the region; and b) Application of a disinfectant to the region, wherein the optically effective substance and the disinfectant are configured such that the optically effective substance is removed by the disinfectant or its optical properties are changed by the disinfectant.

Abstract: An optical probe, instrument, and method for measuring a tissue sample. The optical probe comprises a needle having a needle tip formed to penetrate a tissue surface and an optical waveguide arranged to transmit light through the needle; and a probe housing for holding the needle and comprising at least one of an actuator or a sensor configured to receive or generate a depth signal to determine a depth position of the needle tip relative to the tissue surface.

Abstract: Systems and methods are provided for preparation of orthodontics and prosthodontics. A method may include scanning a patient's teeth to form first 3D data of the patient's teeth including a removable element that obscures part of the dental surfaces of the patient's teeth and non-obscured tooth surfaces, removing the removable element form the patient's teeth so that the removable element no longer obscures the part of the dental surfaces of the patient's teeth, and scanning the previously obscured part of the dental surfaces of the patent's teeth and the non-obscured tooth surfaces.

Abstract: A method of diagnosing intraocular tumors including illuminating a tissue sample using a pulsed light source resulting in output of heat and thermoelastic expansion of the tissue sample. The thermoelastic expansion of the tissue sample produces propagating waves in ultrasonic frequencies. The propagating waves are acquired using an ultrasound system and back-projection reconstruction, thereby mapping anatomies with optical contrast at ultrasonic resolution to image intraocular tumors.

Abstract: An apparatus according to an aspect of the present invention includes an acquisition unit is configured to acquire a blood pressure value of a subject measured by a blood pressure measurement unit, a first pulse rate of the subject at a normal time, and a second pulse rate of the subject in a time period in which the blood pressure value is measured, a calculation unit is configured to calculate a first tension degree of an autonomic nerve of the subject based on the first pulse rate and to calculate a second tension degree of the autonomic nerve of the subject based on the second pulse rate, and a determination unit is configured to determine a type of blood pressure of the blood pressure value based on the blood pressure value, the first tension degree, and the second tension degree.

Abstract: According to a first aspect of the invention, an information processing apparatus includes an information acquisition unit configured to acquire first blood pressure information and second blood pressure information that is information earlier than the first blood pressure information, a blood pressure fluctuation detector configured to detect a blood pressure fluctuation exceeding a first reference value from the first and second blood pressure information, and a fluctuation information output unit configured to output blood pressure fluctuation information that reports the blood pressure fluctuation.

Abstract: A congenital heart disease monitor utilizes a sensor capable of emitting multiple wavelengths of optical radiation into a tissue site and detecting the optical radiation after attenuation by pulsatile blood flowing within the tissue site. A patient monitor is capable of receiving a sensor signal corresponding to the detected optical radiation and calculating at least one physiological parameter in response. The physiological parameter is measured at a baseline site and a comparison site and a difference in these measurements is calculated. A potential congenital heart disease condition in indicated according to the measured physiological parameter at each of the sites or the calculated difference in the measured physiological parameter between the sites or both.

Abstract: A method of determining a risk probability of vertebral artery dissection (VAD) in a patient, including receiving medical image information of the patient and clinical report information of the patient; extracting at least one biomarker corresponding to a vertebral artery segment included in the medical image information; extracting patient history information from the clinical report information; and determining the risk probability of VAD using a deep learning classification model based on the extracted at least one biomarker and the extracted patient history information.

Abstract: A hemodynamic parameter (Hdp) monitoring system for diagnosing a health condition of a patient and for establishing Hdp marker values or Hdp surrogate marker values for purposes of comparison with Hdp values of a patient is provided. An Hdp monitor senses, measures, and records Hdp values exhibited by the patient during a basal or non-exposure period and furthermore Hdp values exhibited by the patient during or after an exposure period during which the patient is exposed to low-energy electromagnetic output signals. An electrically-powered generator is adapted to be actuated to generate said low-energy electromagnetic carrier output signals for exposing or applying to the patient such output signals during said exposure period.

Abstract: A hemodynamic monitor implements an adaptive method that optimally estimates scaling and offset calibration parameters by using a computationally efficient, iterative online method to minimize the mean square error between a high bandwidth arterial pressure cardiac output (APCO) measurement generated by a first physiological sensor affixed to a patient and a relatively low bandwidth continuous cardiac output (CCO) measurement generated by a second physiological sensor also affixed to the patient. When calibration parameters are used to adjust an APCO measurement, the combined APCO/CCO estimate provided by the hemodynamic monitor has accuracy comparable to a CCO measurement, but also tracks cardiac output dynamical variations that are outside of the CCO algorithm bandwidth.

Abstract: The invention provides various methods of identifying myocardial infarction (MI) patients who have microvascular obstruction (MO), persistent microvascular obstruction (PMO), reperfusion hemorrhage, iron deposition, chronic iron deposition, and/or fat infiltration/accumulation. The invention provides various methods of identifying myocardial infarction (MI) patients who are at risk of prolonged inflammation burden in heart, adverse cardiac remodeling, electrical abnormality, mechanical abnormality, malignant cardiac arrhythmia, ischemic heart failure, and/or sudden cardiac death. The invention also provides various methods of treating these MI patients with chelation drugs, anti-inflammatory drugs, fat-lowering drugs, cooling therapies, or device therapies, or their combinations.

Abstract: A method for adjusting an output signal of a pulse diagnosis device includes obtaining a pulse signal at a pulse diagnosis region that is acquired by a sensing element of the pulse diagnosis device, and performing a parameter recognition on the pulse signal to obtain a parameter of the pulse signal, and determining a biological structure of the pulse diagnosis region based on the parameter of the pulse signal. The method also includes determining an adjustment factor for the parameter of the pulse signal based on the biological structure, and adjusting the parameter of the pulse signal based on the adjustment factor for the parameter of the pulse signal, to obtain an adjusted pulse signal for the pulse diagnosis region. The pulse signal is a pressure signal applied by an artery in the pulse diagnosis region to an external skin surface corresponding to the artery.

Abstract: A method for providing personalized health assessment of a subject includes: receiving a raw electrocardiography (ECG) signal of a subject from an ECG device and a raw blood pressure (BP) signal of the subject from a BP waveform detector; calculating a beat-to-beat ECG signal from the raw ECG signal; calculating a beat-to-beat BP signal from the raw BP signal; calculating a beat-to-beat pulse arrival time (PAT) signal that is measured as a time delay between the beat-to-beat ECG signal and the beat-to-beat BP signal; calculating an interpolated beat-to-beat PAT signal and an interpolated beat-to-beat BP signal by interpolating the beat-to-beat PAT signal and the beat-to-beat BP signal, respectively; assessing a subject-specific relationship between the interpolated beat-to-beat PAT signal and the interpolated beat-to-beat BP signal; and estimating a real-time blood pressure of the subject based on the subject-specific relationship.

Abstract: We disclose a system and method for estimating values of hemodynamic parameters of a subject, by calibrating arterial pressure during one time and tracking arterial pressure at another time.

Abstract: A sphygmomanometer includes a frame that spatially demarcates a region in which a display screen is displayed. On the display screen, a scale indication for making a value of pressure readable is displayed along one direction. On the display screen, a mark that represents a pressure of a cuff by a position of the mark with respect to the scale indication is displayed. When the pressure changes, a display control unit performs control to slide the scale indication with respect to the frame along the one direction at a slide speed corresponding to a predetermined pressure change rate or a pressure change rate obtained by actual measurement in a pressurizing process or a depressurizing process of the cuff so that the mark falls within the frame.

Abstract: The present disclosure generally relates to wearable devices and methods for measuring a photoplethysmographic (PPG) signal. The wearable devices and methods described herein are capable of obtaining PPG signals by employing a PPG sensor array configured to receive light at angles associated with a high perfusion index. Viewing components may be coupled to the PPG sensor array to effect transmission of light at these preferential angles.

Abstract: A biosignal sensor includes a substrate, first light-emitting elements, second light-emitting elements, and light-receiving elements. The light-receiving elements are positioned individually spaced apart by different distances from the first light-emitting elements and the second light-emitting elements and receive light from the first light-emitting elements and the second light-emitting elements. The plurality of light-receiving elements are linearly or substantially linearly aligned in an X direction. The first light-emitting elements and the second light-emitting elements are located at positions different in a Y direction from positions of the plurality of light-receiving elements.

Abstract: The present disclosure relates to a PPG signal collection method and apparatus. The method includes: collecting, by using a light sensor, a first PPG detection signal formed by a first light source, where the first light source is a green light source; collecting, by using the light sensor, a second PPG detection signal formed by a second light source, where the second light source is a red light source; further, determining, according to the first PPG detection signal, whether the first light source meets a preset collection indicator; if the first light source meets the collection indicator, determining, according to the second PPG detection signal, whether the second light source meets the collection indicator; and if the second light source meets the collection indicator, collecting, by using the light sensor, a PPG signal formed by the second light source.

Abstract: A bio-electrode composition includes (A) an ionic material and (B) a silicon material powder. The component (A) is a polymer compound containing a repeating unit-a having a structure selected from an ammonium salt, a sodium salt, a potassium salt, and a silver salt of any of fluorosulfonic acid, fluorosulfonimide, and N-carbonyl-fluorosulfonamide. Thus, the present invention provides a bio-electrode composition capable of forming a living body contact layer for a bio-electrode that is excellent in electric conductivity and biocompatibility, is light-weight, can be manufactured at low cost, and can control significant reduction in the electric conductivity even when the bio-electrode is wetted with water or dried; a bio-electrode including a living body contact layer formed of the bio-electrode composition; and a method for manufacturing the bio-electrode.

Abstract: A neural interface arrangement has multiple probes for subdural implantation into or onto a human brain. Each probe has at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the electrode(s), and a transmitter for wirelessly transmitting data signals arising from the electrode(s). An array of coils is implanted above the dura beneath the skull, for inductively coupling with the coil of each probe, and for transmitting power to the probes. A primary coil is connected to the coil array, for inductively coupling with an external transmitter device, and for receiving power from the external transmitter device. In use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the coil array to transmit power to the probes by inductive coupling, and the probes wirelessly transmit data signals arising from the electrodes.

Abstract: The present technology relates generally to the field of electrophysiology and specifically to automated devices, components, systems, and related methods for monitoring potential injury to the nervous system using evoked potentials during intraoperative neurophysiologic monitoring.

Abstract: A core-shell nanowire, a method of forming the core-shell nanowire and a stretchable composite comprising the core-shell nanowire are provided. The core-shell nanowire comprises a core comprising a conductive metal and a shell comprising a biocompatible metal. The method of forming the core-shell nanowire comprises a step of forming a core-shell nanowire by carrying out epitaxial growth of a biocompatible metal on a surface of a core comprising a conductive metal. The stretchable composite comprises a first core-shell nanowire/polymer composite comprising first core-shell nanowires and a first polymer, a first insulating layer disposed on the first core-shell nanowire/polymer composite, and a second core-shell nanowire/polymer composite disposed on the first insulating layer and comprising second core-shell nanowires and a second polymer.