Abstract: The present invention relates to an electrocardiogram measurement apparatus (measurement sensor) which can be used in combination with a smartphone by an individual. The electrocardiogram measurement apparatus according to the present invention comprises: two amplifiers for receiving electrocardiogram signals from a first electrode and a second electrode; one electrode driving unit; a third electrode for receiving an output of the electrode driving unit; an A/D converter connected to an output terminal of each of the two amplifiers and converting analog signals into digital signals; a microcontroller for receiving the digital signals from the A/D converter; and a communication means for transmitting the digital signal, wherein: the microcontroller is supplied with power from a battery; the microcontroller controls the A/D converter and the communication means; and each of the two amplifiers amplifies one electrocardiogram signal so as to simultaneously measure two electrocardiogram signals.

Abstract: An implantable medical device includes a memory storing criteria for transitioning between states of a cardiac cycle model, the states including a P-wave state. The device also includes sensing circuitry that senses a cardiac signal that varies as a function of a cardiac cycle of a patient, and also includes processing circuitry coupled to the sensing circuitry. The processing circuitry is configured to detect an R-wave in the sensed cardiac signal, to determine an elapsed time since the detection of the R-wave, to determine one or more morphological values of a post-R-wave segment of the cardiac signal to compare the elapsed time and the one or more morphological values to the stored criteria for transitioning between the plurality of states of the cardiac cycle model, and to detect a P-wave in the sensed cardiac signal in response to a transition to the P-wave state of the cardiac cycle model.

Abstract: A magnetic measuring device includes a magnetic sensor and multiple plate parts. At least one of the plate parts holds the magnetic sensor, and the plate parts are detachably joined to each other at edges of the plate parts.

Abstract: Apparatus for assessing scarring of cardiac tissue, consisting of a probe and a processor. The probe has one or more electrodes, which are configured to contact the tissue at a plurality of positions and to sense respective voltages in the tissue at the positions. The processor receives the respective voltages, and computes a triangular mesh that is representative of a surface of the tissue and that consists of multiple triangles having vertices corresponding to the positions contacted by the one or more electrodes. The processor calculates respective scar areas within the triangles by comparing the respective voltages sensed at the positions corresponding to the vertices to a predefined range of the voltages that is associated with scarring, and computes a sum of the respective areas. The processor compares the sum to a total area of the triangles so as to assess a degree of the scarring of the tissue.

Abstract: The disclosure relates generally to applications of Orientation Independent Sensing (OIS) and Omnipolar mapping Technology (OT) to various system, device and method embodiments as recited herein. Similarly, systems and methods suitable for supporting OIS and OT systems and methods are disclosed. Further, OIS and OT implementations that provide end user interfaces, diagnostic indicia and visual displays generated, in part, based on measured data or derived from measured data are also disclosed. Embodiments also describe applying optimization techniques to determine the greatest voltage difference of a local electric field associated with an electrode-based diagnostic procedure and a vector representation thereof. Various graphic user interface related features are also described to facilitate orientation and electrode clique signal display.

Abstract: A biometric information presentation system that enables efficient training by obtaining biometric information without giving a subject a sense of discomfort. The biometric information presentation system uses a garment-type biometric information measuring apparatus including at least fabric having a 20% elongation stress of 20 N or less. A garment pressure of the garment-type biometric information measuring apparatus is 0.1 kPa or more and 1.5 kPa or less. A skin contact-type electrode is provided at a portion of the garment-type biometric information measuring apparatus at which a garment pressure is 0.3 kPa or more. The garment-type biometric information measuring apparatus is worn by the subject. From obtained electrocardiographic information is calculated an RRI, an indicator of parasympathetic activity and indicator of sympathetic activity.

Abstract: An electroencephalogram measurement system includes an acquisition unit, an impedance measurement unit, and an output unit. The acquisition unit acquires electroencephalogram information representing an electroencephalogram obtained by an electrode unit that is placed on a region of interest forming part of a subject's head. The impedance measurement unit measures an impedance value between the electrode unit and the subject's body in an acquisition mode in which the acquisition unit acquires the electroencephalogram information. The output unit outputs the impedance value measured.

Abstract: An implantable device includes one or more electrodes to sense an electrical signal from a brain and a waveform analyzer to identify a half wave in the electrical signal; determine an amplitude and a duration of the half wave; determine if the amplitude satisfies a half wave amplitude criterion defined by a set of amplitude parameters comprising a minimum half wave amplitude and a maximum half wave amplitude; determine if the duration satisfies a half wave duration criterion defined by a set of duration parameters comprising a minimum half wave duration and a maximum half wave duration; and identify the half wave as a qualified half wave when the half wave amplitude criterion and the half wave duration criterion is satisfied. A neurological event may be detected based on one or more qualified half waves and electrical stimulation therapy may be delivered to the brain in response to the detection.

Abstract: Provided herein are skin-mounted biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided, including electronic devices useful for establishing conformal contact with the skin of a subject. Devices disclosed herein can comprise a plurality of sensing and/or actuating devices provided as part of a skin-mounted flexible or stretchable electronic circuit.

Abstract: Long-term electrocardiographic and physiological monitoring over a period lasting up to several years in duration can be provided through a continuously-recording insertable cardiac monitor. The sensing circuitry and the physical layout of the electrodes are specifically optimized to capture electrical signals from the propagation of low amplitude, relatively low frequency content cardiac action potentials, particularly the P-waves that are generated during atrial activation and storing samples of captured signals. In general, the ICM is intended to be implanted centrally and positioned axially and either over the sternum or slightly to either the left or right of the sternal midline in the parasternal region of the chest.

Abstract: An apparatus for measuring electrodermal activity can include a first electrode in contact with a first portion and a second electrode in contact with a second portion of a stratum corneum, and in electronic communication with the second electrode through the stratum corneum. A processing module is electrically coupled to the first electrode and the second electrode and is operable to (a) bias the first electrode at a first voltage V+ and the second electrode at a second voltage V? (b) measure a current flowing between the first electrode and the second electrode, the current corresponding to the conductance of the stratum corneum, (c) subtract a compensation current from the measured current (d) measure a resulting current producing an amplified output voltage (e) measure a conductance of the stratum corneum, and (f) adjust at least one of the first voltage, the second voltage and the compensation current to desaturate the output voltage.

Abstract: A magnetic resonance (MR) apparatus and method for controlling a generation of an imaging sequence for imaging a subject. The method includes generating an MR tracking sequence for tracking a position of an MR active device located in the subject; obtaining MR signals detected by the MR active device as a result of the generated tracking sequence; processing the obtained MR signals to determine the position of the MR active device; determining whether a trigger condition is satisfied by comparing the determined position of the MR active device to a predetermined trigger position; and generating the imaging sequence if the trigger condition is satisfied, wherein if the trigger condition is not satisfied, the imaging sequence is not generated.

Abstract: A system detects extravasation or infiltration by segregating active components that drive a passive sensor for economical single use. A receiving antenna of the passive sensor receives a transmitted signal comprising RF electromagnetic power. A first circuit transmits a first portion of the received signal through a body portion. A sensor detects a resultant signal from the body portion. A second circuit combines a reference signal comprising a second portion of the received signal with the resultant signal so as to define an output signal. A transmit antenna transmits the output signal to a receiver.

Abstract: An in-scale display device is provided. The in-scale display device includes at least one flexible electronic display screen that is configured to display at least one reference image in-scale with a subject. A medical device position guidance system including the in-scale display device and an invasive medical device system, and a method of using the medical device position guidance system, are also provided.

Abstract: An in-scale display device is provided. The in-scale display device includes a tablet or mobile device having an electronic display screen that is configured to display at least one reference image in-scale with a subject. A medical device position guidance system including the in-scale display device and an invasive medical device system, and a method of using the medical device position guidance system, are also provided.

Abstract: The present invention relates to a breath tester. The breath tester includes a sensor for sensing a mind-altering substance in breath from a blower (i.e. person blowing an providing a sample). A breath guide is provided for guiding the breath so that it is not returned to the blower. Advantageously, the guide guides the breath so that it is not returned to the blower to thereby minimise the likelihood of spread of infectious disease.

Abstract: According to one embodiment, an information processing apparatus includes a signal acquisition unit that acquires a signal representing a movement of a subject from a sensor that detects the movement of the subject, a measurement unit that measures at least one of an activity amount and a number of steps of the subject based on the signal representing the movement of the subject, and an estimation unit that estimates a situation of the subject based on at least one of the activity amount or the number of steps.

Abstract: An apparatus, and the method of using it, comprising one, or more, electronic sensors attached to a part(s) of a human or animal's body. The patient then performs an activity, or has an activity performed on them, and the results of the measured parameters are recorded by the sensor and processed, or downloaded and processed. The sensor may include a range of instrumentation, e.g. accelerometers, magnetometers, gyroscopes, force sensors, etc. to record positions (in the X, Y and Z planes), movements, angular movements, forces, stresses in bones/joints, etc. The use of the apparatus and method are appropriate to medical treatments, and perfecting sporting or dancing techniques and the results are processed to give the clinician or coach appropriate information to improve the problem being addressed. Methods for measuring lateral angular movement of hinged joints and spinal extension are taught.

Abstract: Systems and methods are provided for evaluating hearing health of a given user. An input audio signal is transformed into the frequency domain and a first and second hearing profile are applied to the input audio sample. The first hearing profile represents a healthy hearing standard and the second hearing profile is the given user's hearing profile. Using the hearing profiles, first and second perceptually relevant information (PRI) values are generated for the input audio sample. The first and second PRI values are analyzed against each other to generate a PRI index value for the given user, where the PRI index value is a hearing health index value for the given user. The given user's hearing profile may additionally be applied to differently processed audio samples to evaluate the amount of perceptual rescue offered by various digital signal processing algorithms.

Abstract: Acoustic immittance and other characteristics of ears may be determined by measuring eardrum displacements resulting from application of pressure to the eardrum. For example, optical coherence tomography may be applied to monitor eardrum displacements responsive to a sound. The pressure corresponding to the sound is measured by a suitable instrument such as a microphone. The measured displacements and pressures may be processed to obtain a measure of immitance.

Abstract: A method for in-vivo cancer diagnosis within a living tissue. The method includes preparing an electrochemical probe by fabricating three integrated electrodes via coating a layer of vertically aligned multi-walled carbon nanotubes (VAMWCNTs) on tips of three electrically conductive biocompatible needles, putting the tips of the three integrated electrodes in contact with a portion of the living tissue by inserting the tips of the three integrated electrodes into the portion of the living tissue, recording an electrochemical response from the portion of the living tissue, where the electrochemical response may include a cyclic voltammetry (CV) diagram with an oxidation current peak of hypoxic glycolysis chemical reaction in biological cells within the portion of the living tissue, and detecting cancer-involving status of the portion of the living tissue based on the oxidation current peak.

Abstract: Devices, systems, methods and kits for releasably mounting a medical device on the body or skin of a user are provided. Embodiments include a holder or mounting unit or structure that retains a medical device in a fixed position on a body part of a user or host, such as on the surface of the skin, and/or provides physical and/or electrical coupling to one or more additional components which may be operatively positioned above and/or below the surface of the skin.

Abstract: Methods and devices of collecting ISF from skin. The methods may include inserting an array of microneedles into a patients skin to form apertures in the patients skin, facilitating ISF mobilization within the skin, and collecting ISF that flows from the apertures. The devices may include an array of microneedles extending from a backing structure. The devices also may include a collection matrix for collecting ISF and/or means for facilitating ISF mobilization.

Abstract: Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Abstract: The invention includes method and materials designed to measure the material properties (e.g. thickness) of layers of material in a sensor using non-Faradaic EIS (Electrochemical Impedance Spectroscopy) methods. The methods are non-destructive, very sensitive and rapid. Typically in these methods, an AC voltage is applied to the desired material layer while the output current and therefore impedance is measured. This voltage can be applied in multiple frequencies in sweep mode in order to detect both the material and, for example, the thickness of the target material. In this way, EIS allows the characterization of properties of various layers of material disposed in devices such as electrochemical glucose sensors.

Abstract: An apparatus for estimating a concentration of an analyte may include a processor configured to measure a first scattering coefficient of an object at a first wavelength and a second scattering coefficient of the object at a second wavelength, obtain a third scattering coefficient of the object at the third wavelength based on the first scattering coefficient and the second scattering coefficient, measure reflectance of the object at a third wavelength, and estimate the concentration of the analyte based on the obtained third scattering coefficient and the measured reflectance.

Abstract: Provided are methods and apparatus for receiving sensor data from an analyte sensor of a sensor monitoring system, processing the received sensor data with time corresponding calibration data, outputting the processed sensor data, detecting one or more adverse conditions associated with the sensor monitoring system, disabling the output of the sensor data during the adverse condition time period, determining that the one or more detected adverse conditions is no longer present in the sensor monitoring system, retrieving the sensor data during the adverse condition time period, processing the retrieved sensor data during the adverse condition time period, and outputting the processed retrieved sensor data.

Abstract: Method and system for providing analyte sensor alignment and retention mechanism for improved connectivity with a transmitter unit for electrical connection, and further including transmitter unit contact pins with metal components to improve electrical conductivity with the analyte sensor in an analyte monitoring and management system is provided.

Abstract: A medical instrument and method thereof for performing a measurement on a biological sample using a test strip are disclosed. The medical instrument may comprise: an analytical unit for analyzing the test strip, wherein the analytical unit comprises a test strip mount which receives the test strip to perform the measurement; a test strip port which receives the test strip, wherein the test strip port is aligned with the test strip mount along an insertion direction; and a shutter movable between open and closed positions, the shutter comprises a test strip opening, wherein the test strip opening is aligned with the test strip port and the test strip mount when the shutter is in the open position, wherein the shutter comprises a shutter mechanism that rotates the shutter parallel to the insertion direction about a rotational axis to move the shutter between the open position and the closed position.

Abstract: A measuring arrangement for in-vivo determination of the lactate concentration in blood by means of electrochemical impedance spectroscopy, comprising a substantially flat shaped probe having a longitudinal extension, a transverse extension and a thickness, wherein the longitudinal extension and the transverse extension of the probe are each a multiple of the thickness of the probe, an analyzer circuitry connected to the probe, and communication means connected to the analyzer circuitry for transferring data via a WPAN, wherein the substantially flat shaped probe is arranged at an edge of the measuring arrangement, so that the probe, during operation of the measuring arrangement, faces the animal or human body to be examined, in such a manner that the probe is arranged with its longitudinal and transverse extensions approximately parallel to the surface of the body to be examined, a wristband therefor, and a method for the operation thereof.

Abstract: Brain activity of a user is detected, and a mental state of the user is determined. In one technique, life/work context is automatically presented to the user in a manner that modulates the mental state of the user. In another technique, an entertainment selection is presented to the user, and an entertainment selection list is automatically modified in response to the determined mental state of the user. In still another technique, the mental state that is determined is a negative emotional state, and life/work context is automatically presented to the user in a manner that promotes a cognitive state of the user in response to the determined emotional state of the user. In yet another technique, the wellness of the user is automatically tracked over a time period based on the determined mental state.

Abstract: A system and method for health diagnostics and more specifically to an image-capture based system and method for detecting physiological state for a subject. The system provides a remote and non-invasive approach by which to detect physiological state with a high confidence. The system enables monitoring of hemoglobin concentration changes by optical imaging and related detection systems.

Abstract: A physiological condition assessing method includes: acquiring a driving-time physiological data measured when a subject is driving a vehicle; acquiring a driving-characteristic data indicating driving characteristics; acquiring a period driving-time physiological data, a period driving-characteristic data and period non-driving-time physiological data corresponding to a first period including the measurement time point of the driving-time physiological data and the measurement time point of the driving-characteristic data, and a second period having a different length to the first period; generating a driving-time physiological feature from the driving-time physiological data and the period driving-time physiological data; generating a driving-characteristic feature; generating a non-driving-time physiological feature quantity; and assessing a physiological condition of the subject, from the non-driving-time physiological feature and at least one of the driving-time physiological feature and the driving-char

Abstract: A pressure-measuring system, including a tube system having at least first and second pressure measuring devices, each including a pressure transducer membrane and a measuring chamber. A first flow regulation device with a perfusion tube section is positioned between the first pressure measuring device and a supply of fluid, and has a first tube clamp that acts on a tube section by squeezing. The system further includes at least one non-perfusion regulation device.

Abstract: A method of assessing a muscular disability and, preferably, spinal muscular atrophy (SMA) in a subject is disclosed. A performance parameter is determined from a dataset of pressure measurements of the individual finger strength from the subject using a mobile device and is compared to a reference whereby the muscular disability and, preferably, SMA is assessed.

Abstract: Embodiments of the present invention provide a method, system, and program product for event detection and/or notification of events occurring. A user monitoring system sends messages based on determinations of impacts associated with the user. The monitoring system receives data from at least one computing device affixed to a user. The data corresponds to a pattern of movement of the user. The monitoring system determines that the user is performing an activity that has an associated known pattern of impacts. The system generates a customized pattern of impacts for the activity by modifying the known pattern of impacts based on the pattern of movement of the user. The system generates a message based on a comparison of measured movement data of the user and the customized pattern of impacts.

Abstract: According to an embodiment, a method for diagnosing traumatic brain injury (TBI) in a subject may include repeatedly measuring heart rate variability (HRV) in the subject and a plurality of HRV altering variables; calculating an HRV fingerprint based on the subject's measured HRV and the measured plurality of HRV altering variables; generating a predicted HRV of the subject based on the HRV fingerprint; and diagnosing a TBI in the subject when the measured HRV of the subject deviates from the predicted HRV of the subject.

Abstract: A treatment efficacy of a treatment for treating a parkinsonian disease is determined. A first set of imaging information/data associated with a dMRI scan of an individual's brain captured at a first time and a second set of imaging information/data associated with a dMRI scan of the individual's brain captured at a second time are received. The individual underwent the treatment for a time period comprising at least part of the time between the first and second times. An expected change between the first and second times is determined based on a natural progression of the parkinsonian disease. The first and second sets of imaging information/data are analyzed to determine a first free-water pattern and a second free-water pattern. Based on the first and second free-water patterns, a disease progression score is determined. Based on the disease progression score and the expected change, a treatment efficacy for treating the individual with the treatment is determined.

Abstract: The present disclosure processes a user's medical data for each year to be input to a machine learning device for predicting dementia, and a data set composed of optimal features is constructed. The optimal features include at least information on the user's disease history, and the user's medical information for each year in the last 7 years or less. Precise prediction and diagnosis of dementia may be made by constructing the optimal features identified through experiments in the user's medical data for each year. Since the experimental results show that the prediction results of observing a disease history of 7 years or less may be the best, rather than observing medical information for a long period of time, the appropriate criteria may be suggested for predicting dementia.

Abstract: A cognitive function evaluation device includes: an obtainment unit that obtains use information indicating a state of use of a toilet by a subject; a calculation unit that calculates a total number of times of use of a toilet by the subject, based on the use information obtained by the obtainment unit; an evaluation unit that evaluates a cognitive function of the subject, based on the total number of times of use calculated by the calculation unit; and an output unit that outputs a result of evaluation performed by the evaluation unit.

Abstract: The Invention of a method of Closing an Orifice located right behind the Epiglottis under the vocal cords unlocks the keys of Immune System and adjusts the Endocrine system. This Orifice is responsible of letting Saliva streaming abnormally into capillaries to imbue them with extra water and inhibiting digested nutrients of Plasma to enter capillaries due to deregulation of Starling Forces. A phenomenon that damages capillaries membranes by creating perforations and reducing the functioning capacity of the lymphatic system and T, B and NK Cells, responsible of enhancing the Immune System. Closing this Orifice will drain out Extra water (Saliva) of capillaries and regulate Starling forces to enable nutrients to enter bloodstream and to increase cells Metabolism, regulate hormones secretion, enable the maturation of NK cells to kill cancers, regulate blood sugar, regulate blood pressure, repair brain's neurons and reproduce new cells to replace defected ones.

Abstract: There is provided a device (100) for placement on the abdomen (102) of a subject to measure uterine contractions of the subject and a fetal heart rate. The device (100) comprises a rigid base (104) for placement on the abdomen (102) of the subject and a cover (106) configured to connect to the rigid base (104). The cover (106) comprises a flexible portion moveable in response to uterine contractions of the subject. The device (100) further comprises a fetal heart rate sensor (108) mounted on the rigid base (104) and configured to measure the fetal heart rate. The device (100) also comprises a uterine contractions sensor (110) located within the device (100) and configured to measure the uterine contractions of the subject.

Abstract: In various embodiments, the invention teaches systems and methods for magnetic resonance imaging. In some embodiments, the invention teaches systems and methods for determining the source of pain in intervertebral discs by measuring one or more physiological biomarkers associated with disc pain and/or disc degeneration.

Abstract: A method and system for actively monitoring anterior cruciate ligament (ACL) strain experienced at the knee joint during athletic activity or dynamic movement. Sensors are used in proximity of the knee joint to actively record parameters such as flexion angle and ground impact force at the knee joint. Sensor measurements are then inputted into a processing unit that will quantify a tibial shear force (TSF) value based on the sensor outputs and dynamically generate user feedback and/or warning signals when unsafe levels of TSF conducive to ACL injury are detected.

Abstract: A monitor recorder optimized for electrocardiography and respiratory data acquisition and processing is provided.

Abstract: An anesthesia stage identification method for identifying an anesthesia stage at which a patient is located is disclosed. The method includes collecting an electroencephalogram signal, calculating at least two characteristics of the collected electroencephalogram signal according to a preset frequency, and determining the anesthesia stage at which the patient is located in a corresponding time period according to the at least two calculated characteristics. The identification method can accurately determine the anesthesia stage, and resolve the problems of abnormal falling during a lucid interval and slow response speed during an induction stage caused by misjudgment.

Abstract: Embodiments of the present systems and methods may relate to a non-invasive system with diagnostic and treatment capacities that use a unified code that is intrinsic to physiological brain function. For example, in an embodiment, a computer-implemented method for affecting living neural tissue may comprise receiving at least one signal from at least one read modality, the signal representing release of photons from mitochondria of the living neural tissue, computing at least one signal to effect alterations to the living neural tissue based on the received input signal, the computed signal adapted to cause transmission of photons to the living neural tissue, and delivering the photons to the living neural tissue to effect alterations to the living tissue.

Abstract: A system for utilizing diagnostics for informed vibrant constitutional guidance includes a diagnostic engine operating on at least a server and configured to receive a first training set including a plurality of first data entries, receive a second training set including a plurality of second data entries, receive at least a biological extraction from a user and generate a diagnostic output including at least a prognostic label and at least an ameliorative process label using the first training set, the second training set, and the at least a biological extraction. The system includes at least an advisory module operating on at least the server and configured to generate at least an advisory output as a function of the diagnostic output and transmit the at last an advisory output to at least an advisor client device.

Abstract: A system for monitoring and identifying the efficacy of posology for a target individual having a health condition with respect to administration of a therapeutic composition assigned thereto for treatment comprises a user interface, a database and a controller in communication with the user interface and the database. The database includes information of health conditions, symptoms, therapeutic compositions, and side effects. The controller comprises a memory of computer implementable steps for receiving information from the user interface regarding the target individual's health conditions, symptoms, therapeutic compositions and side effects assigned to the target individual; comparing the received information to a match with the health conditions, the therapeutic compositions, the symptoms and the side effects; prompting and receiving user feedback; and determining whether the therapeutic composition administered at a dosage should be modified to be increased or decreased.

Abstract: The present invention automatically acquires information about a living body at a time at which an effect of a medicine is generated. The present invention includes an acquisition control unit configured to acquire information about a medicine and time information about when the medicine is to be taken, a calculation control unit configured to calculate an effect generation time period in which an effect of the medicine is estimated to be generated, based on the information about the medicine and the time information, and a biological information acquisition control unit configured to perform processing for acquiring information about a living body, based on the effect generation time period.