Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.

Abstract: The present disclosure describes a non-linear compartmental model using PET-derived data to predict, on a patient-specific basis, the optimal therapeutic dose of cargo carrying antibody (e.g., huA33) such as radiolabeled antibody, the antigen occupancy, residency times in normal and malignant tissues, and the cancer-to-normal tissue (e.g., colorectal cancer-to-normal colon tissue) therapeutic index. In addition, the non-linear compartmental model can be readily applied to the development of strategies such as multi-step targeting (MST) designed to further improve the therapeutic indices of RIT.

Abstract: A light-emitting device includes a light-emitting element with a peak emission wavelength in a range of 400 nm to 410 nm and a fluorescent member that contains a first phosphor with a peak emission wavelength in a range of 440 nm to 470 nm containing a Eu-activated alkaline-earth phosphate that contains Cl in a composition, a second phosphor with a peak emission wavelength in a range of 500 nm to 530 nm containing a Eu-activated halogen-containing alkaline-earth silicate, a third phosphor with a peak emission wavelength in a range of 530 nm to 600 nm containing a Ce-activated rare-earth aluminate, and a fourth phosphor with a peak emission wavelength in a range of 600 nm to 660 nm containing a Eu-activated silicon nitride containing Al and at least one of Sr and Ca in a composition.

Abstract: A self-shielding accelerator is provided, which includes an accelerator assembly, a high-frequency electrode plate, a rectification and voltage multiplication assembly, a solenoid-type transformer assembly, a cooling system assembly and a shielding steel cylinder. The self-shielding accelerator further includes a steel cylinder base connected to the shielding steel cylinder. The accelerator assembly is horizontally fixed to the steel cylinder base. The rectification and voltage multiplication assembly is fixed to the steel cylinder base by a support plate. The high-frequency electrode plate and the solenoid-type transformer assembly are connected to the steel cylinder base through multiple horizontally arranged support columns. The cooling system assembly is fixed to the shielding steel cylinder. The self-shielding accelerator adopts a fully horizontal self-shielding structure, and can be seamlessly joined to the filling production line, which makes online radiation processing possible.

Abstract: Devices, methods, and systems for a luer connector treatment device are described herein. The luer connector treatment device may include one or multiple sources of UV radiation configured to emit UV radiation capable of sterilizing the contents of a treatment chamber while a first medical device (e.g., catheter) is connected to a secondary medical device, and while the first medical device is separate from a secondary medical device. Sources of UV radiation may be located along both a cap and body of the luer connector treatment device.

Abstract: Disclosed herein is a multiple light emitter device which inactivates microorganisms. The device includes at least two light emitters and at least one light-converting material arranged to convert at least a portion of light from the light emitters. Any unconverted light emitted from the light emitters and converted light emitted from the at least one light-converting material mixes to form a combined light, the combined light being white. In one aspect, the light emitters include at least one blue light emitter and at least one violet light emitter. In another aspect, the light emitters include one blue light emitter and one emitter within the range of approximately yellow to infra-red light.

Abstract: A marking device and a sanitization system are disclosed. The marking device comprises a marker and a cap constructed from material that allows UV-C light rays to pass through. In an alternate embodiment, the marking device may be double-sided. In some embodiments, the marking device may be used in conjunction with a sanitization device, and/or the marking device may comprise a tracking device such as an RFID tracking device.

Abstract: An apparatus for sanitizing is provided. The apparatus includes a housing having a reservoir for retaining sanitizing fluid. The apparatus also includes a holder disposed beneath the housing. The apparatus further includes an applicator pad received by the holder and adapted to be in selective fluid communication with the reservoir. The applicator pad includes a dome-shaped portion having a substantially hemi-spherical shape configured to extend into an interior region of a bell of a stethoscope head when the bell is placed over the dome-shaped portion.

Abstract: A floor processing device has a motor-driven floor processing element for processing a floor to be processed, wherein the floor processing element has a hollow space with a hollow space opening that joins the hollow space with the ambient air. A fragrance element is arranged in the hollow space.

Abstract: A microfluidic delivery device and method of dispensing a fluid composition from a microfluidic die are provided. The method includes generating air flow from a fan; directing a first portion of the air flow through a first air outlet in a housing; directing a second portion of the air flow through a second air outlet in the housing; jetting a fluid composition from a microfluidic die through a fluid orifice in the housing; directing the second portion of air flow adjacent to the microfluidic die and out the fluid outlet, wherein the first portion of the air flow directs the fluid composition jetted out of the fluid outlet into the air.

Abstract: An unheated, essential oil diffuser relies on a pressurized air stream to educt oil from a reservoir, followed by separators including separation chambers and an annular channel. The latter is a long channel having an aspect ratio (L/d) of from about 10 to about 120, for length L and thickness d. Thickness d is effective diameter, also known as hydraulic diameter (4 times c.s. area, divided by “wetted” or exposed perimeter), and may be from about 25 to about 100 thousandths of an inch (0.6 to 2.5 mm) across the thin passage, with a target range of from about 55 to 75 mils (0.7 to 1 mm). This geometry provides laminar flow at Reynolds number values less than a few hundred for virtually its complete distance of from under one inch (25 mm) to over three inches (76 mm).

Abstract: A method of treating air passing through an air handling unit having a housing extending around an air handling space and a primary air treatment system that treats air as the air passes through the air handling unit between air inlet and outlet locations on the air handling unit. First and second fixtures are obtained, each having a housing and a UV light source. The first and second fixtures are strategically mounted to the air handling unit so that UV light from each of the UV light sources on the first and second fixtures treats air moving through the air handling unit with the UV light sources on the first and second fixtures energized. The first and second fixtures are serially electrically connected to a power source to thereby cause the UV light sources on the first and second fixtures to be energized through the power source.

Abstract: A wound covering is provided that comprises a substrate and vitamin D, or analogues or metabolites thereof, embedded in the substrate. Methods of making a wound covering are also provided and include the steps of providing a solution that includes a polymer; adding vitamin D, or analogues or metabolites thereof, to the solution to form a mixture; and forming one or more fibers from the mixture that are then embedded with the vitamin D, or analogues or metabolites thereof. Methods of treating a subject are further provided and include the step of applying a wound covering including one or more fibers embedded with vitamin D, or analogues or metabolites thereof, to a site on a subject.

Abstract: The present invention relates to an injectable homogeneous aqueous solution of chitosan containing, in a physiologically acceptable medium, between 0.1 and 4.5% by weight of a chitosan having a degree of acetylation less than 20% and a weight average molecular mass of between 100,000 and 1,500,000 g/mol, said solution having a pH greater than or equal to 6.2, and advantageously between 6.2 and 7.2, said solution not containing any chitosan having a degree of acetylation greater than 20%, said solution being liquid and homogeneous at ambient temperature.

Abstract: The disclosure provides hyaluronic acid (HA) gel formulations and methods for treating the appearance of the skin. The formulations contain hyaluronic acid and at least one additional ingredient. Methods for treating lines, wrinkles, fibroblast depletions, and scars with the disclosed composition are provided as well.

Abstract: The use of lipids in the taper junction or other metal on metal interface of a modular orthopedic implant to prevent fretting corrosion and increase the pull off load. The incorporation of lipids or a lipid-like substrate within the taper junction increases the onset load and decreases the amount of corrosion. The incorporation of lipids also increases the pull-off load necessary to separate the head from the neck. As a result, the use of lipids in the taper junction of an orthopedic implant should reduce the need for revisions of implants, such as such as knee and hip replacements, which are often needed because of fretting corrosion.

Abstract: This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.

Abstract: Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

Abstract: A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles and a suspending agent comprising hyaluronic acid. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.

Abstract: A bone graft substitute for use in orthopedic bone grafting procedures comprising a radiolucent bone graft substitute combined with a temporary radiopaque agent. Methods of making and using the composition are also disclosed. Bone graft substitutes have become an effective means of regenerating bone in orthopedic procedures where bone loss results from surgically created defects or traumatic injury to the bone. Bone graft substitutes include mineral-based materials such as hydroxyapatite, calcium phosphates, and calcium phosphosilicates as well as allograft-derived materials and xenograft-derived materials such as collagen-based matrices and demineralized bone matrices.

Abstract: The present invention is directed to a method for the tunable precipitation of apatite induced by a chemical reaction within a polymeric hydrogel, and the product made thereof. The present invention includes a pH dependent pathway for the hydrolysis of DCPD precursor phase. In addition to pH the stoichiometry of the CaP reactants can contribute to the composition of the CaP phase incorporated into the PVA hydrogels. At elevated pH the direct conversion of DCPD to apatite is observed. However, decreasing the reaction pH to 7.4 to mimic physiological conditions results in the inclusion of OCP as a transition step.

Abstract: A method for reattaching a detached tissue to a hard tissue includes operation in which a suture anchor having a first stitch and a second stitch is provided, wherein the first stitch is divided into a first strand and a second strand, and the second stitch is divided into a third strand and a fourth strand. The suture anchor is fixed on a hard tissue. The first strand, the second strand, the third strand and the fourth strand pass through a detached tissue. A bioinductive patch is provided, wherein the bioinductive patch includes a patch body and a button. The first strand and the third strand pass through the patch body and a first suture hole of the button, and the second strand and the fourth strand pass through the patch body and a second suture hole of the button. The second strand and the third strand are knotted to form a first strand node, and the first strand node presses the bioinductive patch and the detached tissue tightly onto the hard tissue.

Abstract: Medical devices comprise a polymeric body comprising: a base polymeric formulation comprising at least a polymer or co-polymer of propylene; and an additive comprising a copolymer having a polypropylene backbone and hybrid micromolecule side-chains based on organo-functional silanes (PP-g-XSiOA) in the presence of a co-agent, for example, difunctional metallic diacrylate monomers, where “X” is an organic group or an organo-functional group, and “A” is a metal, an inorganic oxide, an inorganic hydroxide, or any other inorganic material. X may be derived from a compound selected from the group consisting of epoxy, amino, acrylate, methacryloxy, and vinyl; and A is selected from the group consisting of: silicon, (Si), aluminum (Al), iron (Fe), titanium (Ti), silver (Ag), zinc (Zn), nickel (Ni), calcium (Ca), copper (Cu), tin (Sn); oxides thereof; hydroxides thereof; and mixtures of the foregoing. Antimicrobial agents are included in the polymeric body. The medical devices have enhanced antimicrobial properties.

Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

Abstract: Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process.

Abstract: Functionalized copolymers of isoolefins and conjugated diolefins, methods of preparing the copolymers, and their use as compatibilizers are disclosed. The diolefin monomer units of the co-polymer are modified at the C—C double bond along the backbone of the copolymer to include an oxygen containing functional group such as epoxide, ester or alcohol. The functionalized copolymers improve the wettability of a non-hydrophilic surface towards hydrophilic polymer and allows for the formation of homogenous layers of the hydrophilic polymers. In particular, the spreading of a hydrophilic polymer on a non-hydrophilic substrate is facilitated by applying the co-polymers as an interfacial layer between the two incompatible materials. The resulting coated substrates exhibit resistance to protein adsorption and cell growth after grafting. The co-polymers are especially suited in the coating of biomedical devices where a high degree of uniformity of the coated surface is required.

Abstract: The present invention is directed to an adherent resorbable matrix for use in surgical applications. The adherent resorbable matrix includes a biocompatible adherent material including chitosan.

Abstract: A bandage has a first sheet overlying a wound and located adjacent to it and a top sheet overlying the first sheet. The first sheet has a plurality of discrete passageways overlying the wound and adapted to communicate negative pressure established by a negative pressure source to the wound.

Abstract: A method of treating a tissue site is provided. The method includes applying a reduced pressure to a tissue site with a reduced pressure source. A source pressure is monitored at the reduced pressure source, and a differential pressure is determined between the source pressure and the desired tissue site pressure. If a blockage is present between the reduced pressure source and the tissue site, the differential pressure is limited to a first maximum differential pressure. If no blockage is present between the reduced pressure source and the tissue site, the differential pressure is limited to a second maximum differential pressure.

Abstract: A breast pump device (1) is adapted to enable realization of at least two batches (A, B) of breast milk as a direct result of a single pumping session to be performed on at least one user's breast, which batches (A, B) are different as far as the value of at least one quality parameter of the breast milk is concerned. The device (1) comprises a detection unit (50) for performing real-time detection of the at least one quality parameter in a flow of breast milk and outputting a detection signal representing an actual value of the at least one quality parameter, and further comprises a controller (70) for receiving the detection signal from the detection unit (50) and using the signal in a process of determining an appropriate setting of the device (1) as far as the choice of a destination position of the milk is concerned.

Abstract: A pump apparatus and method for extracting breast milk is disclosed. The pump includes a first interface component to stimulate a Milk Ejection Reflex (MER) and a second interface component to extract breast milk. Milk is extracted through an improved method that more closely replicates the suckling of an infant.

Abstract: To provide a simple embodiment of a rotor (2) for a fluid pump which is nevertheless very flexible in handling and compressible, in accordance with the invention a conveying blade is provided having at least two struts (12, 13, 14) and a membrane spanned between them in the expanded state, wherein the struts each have at least one joint, in particular more than one joint, which enables an angling in a first direction in a first movement plane and bounds an overelongation beyond an elongation angle of in particular 180° in the opposite second direction. In particular when a plurality of joints (15, 16, 17) are provided at the struts, they, and with them the conveying blades, are particularly flexible for simple compressibility.

Abstract: A ventricular assist system including an implantable rotary pump, a pump drive circuit for supplying power to the pump, and a signal processing circuit receiving one or more electrophysiological signals and one or more physiological signals of the subject. The signal processing circuit is operable to receive inputs from the one or more electrophysiological sensors and the physiological sensor, and determine the presence or absence of a non-normal sinus cardiac rhythm condition based on the input from the electrophysiological sensors. In the presence of a non-normal sinus rhythm, the circuit operates the pump in a modified mode of operation. In the absence of a non-normal sinus rhythm, the circuit operates the pump in a normal mode of operation. In either case, the circuit controls the power to the pump and/or speed of the pump based on the input from the physiological sensor and the mode of operation.

Abstract: A method of controlling a blood pump having a predefined hydraulic performance including at least from the group consisting of estimating and measuring an instantaneous flow rate during operation of the blood pump at a predetermined rotational speed of an impeller of the blood pump, the instantaneous flow rate including a plurality of flow rate data points. The plurality of flow rate data points define a trajectory around at least one from the group consisting of an operational point of a predefined pressure-flow curve associated with the predetermined rotational speed of the impeller of the blood pump and a target operational point of a target pressure-flow curve different than the predefined pressure-flow curve. The predetermined rotational speed of the impeller is adjusted until the plurality of flow rate data points define a predetermined trajectory around at least one of the operational point and the target operational point.

Abstract: A system is provided that includes a plurality of medical treatment units that are respectively associated with a patient, and a plurality of peripheral appliances also respectively associated with a patient. The peripheral appliances transmit control signals and patient signals to the treatment units, while the treatment units receive the control signals and patient signals from the peripheral appliances. The system ensures that the treatment units do not receive patient signals from other peripheral appliances that are not associated with the particular patient. The operating staff allocate a peripheral appliance to a patient and confirm the successful association of the peripheral appliance with the treatment unit allocated to the patient.

Abstract: Dialysis systems and methods for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments, may include a dialysis machine for transferring dialysate to a patient from a dialysate bag, and a warmer pouch for flowing the dialysate through to heat to a predetermined temperature before flowing into the patient. The dialysate may flow from the dialysate bag through the warmer pouch for pumping into the patient via tubing. A filter may be coupled to the warmer pouch, and the filter may be configured to filter out air content from the dialysate.

Abstract: A method for operating a dialysis machine to conduct a dialysis treatment on a patient (e.g., a peritoneal dialysis machine) may include transferring dialysate from a first bag, and automatically determining the dialysate from the first bag has completely transferred. After determining the dialysate has completely transferred from the first bag, switching from the first bag to a second bag of dialysate. The method may further include transferring dialysate from the second bag in response to the detection of the completed transfer of the first bag, and automatically determining the dialysate from the second bag has completely transferred. The method may further include determining if the respective first or second bag has completely transferred by comparing a dialysate bag volume transferred to the patient to a detected volume of the respective first or second bag. Systems with dialysis machines for performing such a method are disclosed as well.

Abstract: Dialysis machines and methods for operating dialysis machines (e.g., peritoneal dialysis machines) may include delivering dialysate to a patient and detecting a temperature of a volume of the dialysate, an air content of the dialysate volume, or another condition, or combinations thereof, wherein the detected temperature of the dialysate volume is compared to a predetermined maximum temperature, the detected air content of the dialysate volume is compared to a predetermined maximum air content and the detected other condition generates a signal. The volume of dialysate may be diverted in response to the detected temperature exceeding the predetermined maximum temperature, the air content exceeding the predetermined maximum air content, or the other condition generated signal, or combinations thereof.

Abstract: A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.

Abstract: A control system controlling the line pressure in a blood supply system (1) in which a pump (14) pumps blood from a reservoir (10) via a primary passage (18) toward a plurality of outlets (16, 26, 26a), wherein one or more outlets are openable to permit flow and closable to block flow, said control system comprises a monitoring arrangement to determine a line pressure in the primary passage, and a controller responsive to the monitoring arrangement and controlling the pump (14) to maintain the line pressure in the primary passage (18) above a pre-set level. The control system practically eliminates the risk of a momentary reduction in blood supply line pressure when an outlet is opened.

Abstract: A blood processing system for collecting plasma reduced platelets and anticipating plasma return includes a venous access device, a blood component separation device, a first return line, a recirculation line, and a second return line. The venous access device draws whole blood from a subject and returns blood components to the subject using a first pump. The blood component separation device separates the drawn blood into a first blood component and a second blood component, and sends the first blood component to a first blood component bag. The first return line fluidly connects the venous-access device and the blood component separation device. The recirculation line connects the first blood component container and the separation device. The second return line fluidly connects the first blood component container and the first return line and is configured to return the first blood component within the first blood container to the subject.

Abstract: Embodiments of a system box for holding a bag system and methods for separating composite liquids are described. In embodiments, a bag system may be a blood bag system used to collect blood, separate the blood into components, store the components, and utilize the components in patients. The system box may hold the blood bag system. Processes can then be performed to separate components from the blood.

Abstract: An irrigation catheter for the treatment of the sinus anatomy is described. The catheter comprises a proximal portion, a rigid middle portion, and a flexible distal portion. The flexible distal portion comprises an irrigation tip and the proximal portion has a stiffness that is intermediate the stiffness of the rigid middle portion and the flexible distal portion. The irrigation tip has a tip opening and one or more radially facing openings. A method for irrigating or suctioning the sinus anatomy includes inserting an irrigation catheter into a patient's anatomy and irrigating or suctioning a target space.

Abstract: According to the invention, there is provided a medical apparatus including: one or more sterile pre-filled syringe; one or more first protective container including the one or more sterile pre-filled syringe, wherein the one or more first protective container is impermeable to moisture and/or sterilizing agents; a second protective container including one or more medical components and the one or more first protective container; and a package impermeable to bacteria including the second protective container.

Abstract: A system and method provide for enhanced reliability and safety of programming and/or operating a medical device, such as an infusion pump, with a remote control device, such as a mobile phone (e.g., a smartphone) can determine whether the smartphone is compatible with the medical device by checking the type and version of the smartphone as well as the versions of the operating software and/or firmware resident on the phone.

Abstract: An injector system for injecting fluid includes a syringe and an injector. The syringe includes a body and a plunger movably disposed within the body. The plunger has at least one flexible leg extending toward the rearward end of the body. The injector has a housing with a front plate, a drive member at least partially disposed within the housing and operable to engage the plunger, and a syringe release assembly operable to release the syringe. The syringe assembly includes a syringe release gear that forms an enclosure for receiving the syringe when the syringe is fully seated within the housing and a plunger release tube surrounding at least a portion of the drive member. The plunger release tube has a first end rotationally engaged with the syringe release gear. Rotation of the syringe release assembly releases the at least one flexible leg from the drive member.

Abstract: The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. A container holds the therapeutic agent and a pressure source has pressurized fluid in selective fluid communication with at least a portion of the container. A catheter, in fluid communication with the container, has a lumen sized for delivery of the therapeutic agent to a target site. In one embodiment, a diameter of particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns, a mass of the particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, a ratio of an inner diameter of the catheter to the diameter of particles is at least 4:1, and a regulated pressure of the pressurized fluid is between about 0.01 psi to about 100 psi.

Abstract: An insertion mechanism for a drug pump includes an insertion mechanism housing; a manifold guide; an insertion biasing members initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the manifold guide; and a manifold having a septum and a cannula, wherein the annular space between the septum and the cannula defines a manifold header. The needle and cannula are inserted into the body of a user by the insertion biasing member(s), after which only the needle is retracted. Retraction of the needle may open a fluid pathway from the manifold header to the body through the cannula. A drug delivery pump includes an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism. Assembly and operation methods are provided.

Abstract: An insertion mechanism and methods of assembly and operation of a drug pump may include an insertion mechanism housing; a housing cap; a manifold guide; an insertion biasing member initially held in an energized state; a retraction biasing member connected to a hub connected to a proximal end of a needle; and, optionally, a clip retainer. The retraction biasing member is held initially in an energized state between the hub and manifold guide. A manifold has a manifold body and one or more septa defining a manifold header. The retraction biasing member may be held initially energized between the hub and the clip retainer. The needle is advanced by the insertion biasing member(s) from the initial configuration to an administration configuration, opening a fluid pathway from the manifold header to the target. The pump may include an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism.

Abstract: The invention relates to an insertion device comprising—a penetrating member (50) connected to transformation means (52), —a moving part (38) comprising guiding means (39) which guiding means (39) restrict the movement of the transformation means (52) and guide the penetrating member (50) from a first to a second position in a first direction, i.e. the direction of insertion, towards the injection site, and—a stationary housing (30) comprising guiding means (32) which guiding means (32) restrict the movement of the moving part (38). The guiding means (32) guide the moving part (38) in a second direction which is linear and different from the first direction i.e. the direction of insertion.