Abstract: The invention relates to a novel antibody and an antibody fragment thereof specifically binding to a B-cell maturation antigen (BCMA), and particularly relates to a fully humanized single-chain variable fragment (scFv). The invention further relates to a nucleic acid encoding the antibody, a vector, and a host cell expressing the nucleic acid. Furthermore, the invention also relates to a composition containing the antibody described herein, and use thereof in treatment and diagnosis.

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

Abstract: The present invention relates to subcutaneous formulations of anti-CD38 antibodies and their uses.

Abstract: Provided herein are antibody molecules that bind specifically to ERBB3 and related nucleic acid molecules, vectors and host cells. Also provided herein are medical uses of such antibody molecules.

Abstract: The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and this can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for production and use of said antibodies and antibody fragments.

Abstract: The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

Abstract: The present invention concerns a method for modifying a polysaccharide material, preferably an amylaceous material, involving a first step of homogeneous solubilisation of said polysaccharide material in an aqueous solvent, followed by a step of homogeneous chemical functionalisation comprising at least one non-crosslinking chemical modification, or at least one crosslinking chemical modification, or a sequence of at least one non-crosslinking chemical modification and at least one crosslinking chemical modification. Secondly, the present invention concerns a modified polysaccharide material, in particular obtained by the method according to the invention, characterised in that it has a novel distribution of the chemical substituents attached to the hydroxyl functions of the anhydroglucose units of said polysaccharide material.

Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.

Abstract: The present invention relates to process for preparing partially deacylated gellan gum, the process comprising subjecting native or high acyl gellan gum to treatment with an esterase capable of partially deacylating gellan gum.

Abstract: The present invention provides a production method for pseudo-polyrotaxane or polyrotaxane in which the degree of ring-shaped molecules included on straight-chain molecules, that is, the inclusion rate, has been controlled to be low and stable.

Abstract: A glycophospholipid polymer is disclosed. The glycophospholipid polymer comprises a reaction product of one or more glycosaminoglycans and one or more phospholipids. Also disclosed is a glycophospholipid polymeric network comprising a reaction product of one or more glycosaminoglycans, one or more phospholipids and, one or more crosslinking agents.

Abstract: The present invention is concerned with a reactive surfactant composition for emulsion polymerization, which is able to micronize the particle diameter of a polymer emulsion and to reduce the addition amount of the reactive surfactant composition to be used. The reactive surfactant composition for emulsion polymerization of the present invention contains a reactive anionic surfactant (component A) represented by the following formula (I), the component A being satisfied with the following requirement R: wherein AO represents an alkyleneoxy group having a carbon number of 3 or more and 18 or less; E represents an ethyleneoxy group; p represents an integer of 1 or more and 15 or less; m? represents an integer of 0 or more; n? represents an integer of 0 or more; M+ represents a hydrogen ion or a cation; and plural kinds of AOs may coexist.

Abstract: Catalysts, catalysts systems and methods of polymerizing olefins are provided. The catalyst system may contain two catalysts. Polyolefin polymers are also provided.

Abstract: A polymerization method including radically polymerizing a monomer in a polymerization medium comprising a chain transfer agent, and a free radical initiator prepared by oxidizing a reaction product of a ligand-reactive decomplexation agent and an alkyl-borane complex of the formula: wherein R1, R2, and R3 are independently selected from hydrogen, an alkyl group containing from 1 to 12 carbon atoms, a cycloalkyl group containing from 3-12 carbon atoms, and an aryl group containing from 6 to 12 carbon atoms, wherein the aryl group may be optionally substituted with an alkyl group having from 1 to 10 carbon atoms, and at least one of R1, R2, and R3 is an alkyl group, a cycloalkyl group or an aryl group, and L is a complexing agent selected from one or more amine groups, amidine groups, hydroxide groups, alkoxyl groups, alkyl ether groups, alkoxide groups and mixtures thereof.

Abstract: A method for preparing polybutene by polymerization of a raw material of a carbon number 4 (C4) compounds having an isobutene amount of 50 to 75% by weight, is disclosed.

Abstract: Provided herein are polyethylene compositions suitable in the fabrication of PE-RT pipes for use in cold and hot water plumbing in accordance with ISO 22391-2, and processes for making the same.

Abstract: An ethylene/butadiene copolymer comprising statistically distributed ethylene units and butadiene units is provided. The molar fraction of the ethylene units in the copolymer is greater than or equal to 50%, relative to the total number of moles of ethylene and butadiene units. The microstructure of the copolymer is homogeneous. A process for preparing such a copolymer and also the uses of this copolymer, in particular in rubber compositions for tires is also provided.

Abstract: A water-responsive interpenetrating polymer network, a preparation method and use thereof, are disclosed in the present disclosure. The water-responsive interpenetrating polymer network comprises an interpenetrating polymer network formed by a cholesteric liquid crystal polymer and a polyionic liquid; wherein the cholesteric liquid crystal polymer is formed by polymerization of a liquid crystal mixture; and the polyionic liquid contains a hydrophilic group or is a hydrophilic salt. The interpenetrating polymer network of the present disclosure is water responsive without needs of activation with an alkaline solution, which simplifies the preparation process, and it has stable water responsiveness performance after prolonged and/or repeated exposure to water. The water-responsive interpenetrating polymer network of the present disclosure can be used to prepare light reflective coatings and reflective devices, and has higher commercial value.

Abstract: Radiation curable compositions for additive fabrication processes, the components cured therefrom, and their use in particle image velocimetry testing methods are described and claimed herein. Such compositions include compounds which induce free-radical polymerization, optionally compounds which induce cationic polymerization, a filler constituent, and a light absorbing component, wherein the compositions are configured to possess certain absorbance values at wavelengths commonly utilized in particle image velocimetry testing. In another embodiment, the compositions include a fluoroantimony-modified compound. Such compositions may be used in particle imaging velocimetry testing methods, wherein the test object utilized is created via additive fabrication and is of a substantially homogeneous construction.

Abstract: A modified conjugated diene-based polymer is provided, having remarkable processability and excellent tensile strength and viscoelasticity properties, and a rubber composition including the same is also provided. The modified conjugated diene-based polymer has a unimodal shape molecular weight distribution curve by gel permeation chromatography, narrow molecular weight distribution and a Mooney stress-relaxation ratio of 0.7 or more, and includes a functional group derived from a modifier represented by Formula 1, and thus has remarkable processability and excellent tensile properties and viscoelasticity properties.

Abstract: A polymer includes a repeating unit represented by Formula (1) and/or a repeating unit represented by Formula (2), and a repeating unit represented by Formula (3) and/or a repeating unit represented by Formula (4), where a proportion of a total of the repeating unit represented by Formula (1) and the repeating unit represented by Formula (2) is greater than 0 mol % but ?100 mol %; a proportion of a total of the repeating unit represented by Formula (3) and the repeating unit represented by Formula (4) is ?0 mol % but less than 100 mol %; a proportion of a total of the repeating unit represented by Formula (1) and the repeating unit represented by Formula (3) is ?20 mol %; and a proportion of a total of the repeating unit represented by Formula (2) and the repeating unit represented by Formula (4) is ?80 mol %.

Abstract: A method for preparing a core-shell copolymer includes polymerizing a core by polymerizing 70 to 90 parts by weight of a methyl (meth)acrylate monomer and 1 part to 20 parts by weight of a C2-C12 alkyl (meth)acrylate monomer, based on 100 parts by weight of the total content of the monomer; at a point when a polymerization conversion ratio is 70% to 90% in the polymerization of the core, polymerizing the core by adding and polymerizing 1 part to 10 parts by weight of the methyl (meth)acrylate monomer and 0.04 to 0.7 parts by weight of a polyfunctional acrylic cross-linking agent; and polymerizing a core-shell copolymer by adding and polymerizing 1 to 10 parts by weight of the methyl (meth)acrylate monomer and 1 to 10 parts by weight of an aromatic vinyl monomer in the presence of the core.

Abstract: Provided is a composition for optical stereolithography the stereolithography (photocuring) of which is completed in a shorter time and which provides a stereolithographic object having excellent strength (strength that prevents the occurrence of a fracture and the like when the stereolithographic object is subjected to an impact, or dropping, and strength with which the stereolithographic object can withstand repeated folding). The composition for optical stereolithography of the present invention includes (A) a diallyl phthalate-based polymer; (B) radical polymerizable compounds having a methacrylic group and/or an acrylic group; (C) a radical polymerization initiator; and (D) a sensitizer. The (B) radical polymerizable compounds includes at least (B1) an epoxy (meth)acrylate having a methacrylic group and/or an acrylic group, or (B2) a dioxane (meth)acrylate having a methacrylic group and/or an acrylic group. The composition contains 0.

Abstract: An ethylene-propylene block copolymer resin is provided that is suitable as an insulation layer of an electric power cable. The ethylene-propylene block copolymer is obtained by polymerization of a propylene homopolymer or an ethylene-propylene random copolymer with an ethylene-propylene rubber copolymer in stages in reactors in the presence of a Ziegler-Natta catalyst obtained using two internal electron donors, wherein one of the two internal electron donors is a compound comprising an ester group and an alkoxy group, the ethylene-propylene block copolymer has a melting temperature of 150 to 160° C., the content of the solvent extract thereof when extracted at room temperature with xylene is 30 to 50% by weight, and the intrinsic viscosity of the solvent extract is 1.5 to 3.0 dl/g.

Abstract: Provided are a (meth)acrylic block copolymer exhibiting good active energy ray curability, in particular, curability of a blend thereof with an acrylate monomer, and an active energy ray curable composition comprising the (meth)acrylic block copolymer. The (meth)acrylic block copolymer includes a methacrylic polymer block (A) having an active energy ray curable group including a partial structure represented by the general formula (1) below wherein R1 denotes a hydrocarbon group having 1 to 10 carbon atoms, and W denotes a saturated hydrocarbon group having 1 to 10 carbon atoms, and an acrylic polymer block (B) having no active energy ray curable groups.

Abstract: A urethane group-containing reactive polyisocyanate composition is disclosed which contains not more than 1 wt % of monomeric starting di-isocyanate based on the total weight of said polyisocyanate composition, having an NCO value in the range 0.1-15%, and wherein said composition comprises urethane groups and allophanate groups and wherein the ratio of allophanate groups over urethane groups is between 0.05 and 100.

Abstract: Disclosed are compositions comprising: a) one or more isocyanate functional components; b) one or more alkoxyalkyl benzoates; and c) one or more catalysts for the reaction of isocyanate moieties with hydroxyl groups. Disclosed is a method of bonding two or more substrates together comprising contacting two or more substrates together with a composition disclosed herein disposed along at least a portion of the area wherein the substrates are in contact. At least one of the substrates may be window glass. One of the other substrates may be a building or a vehicle.

Abstract: The invention relates to a process for preparing a polyurethane foam comprising reacting a polyether polyol and a polyisocyanate in the presence of a blowing agent and an antioxidant, wherein: the antioxidant consists of one or two or more phenolic antioxidants, wherein the one or more phenolic antioxidants contain no atoms other than carbon, hydrogen and oxygen, and the amount of the one or more phenolic antioxidants is of from 2,300 to less than 10,000 parts per million by weight (ppmw) based on the polyether polyol; the isocyanate index is higher than 100; the maximum temperature during the preparation of the polyurethane foam is higher than 140° C.; and the density of the polyurethane foam is lower than 25 kg/m3.

Abstract: A reaction mixture and a process for making a polyisocyanurate comprising rigid foam having a density in the range 50-500 kg/m3 is disclosed, said process having a cream time >35 seconds and a snap cure behaviour.

Abstract: The invention relates to a method for preparing a silane-terminated polymer by reacting a polyol A) with a diisocyanate B), an isocyanatosilane C) and an amino silane E), wherein the polyol component A) is reacted simultaneously with a mixture of at least one diisocyanate B) and one isocyanatosilane C), and the resulting product is subsequently reacted with the amino silane E) to produce the silane-terminated polymer. The method according to the invention can be used to prepare mixed silane-terminated polymers having a low viscosity.

Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.

Abstract: Embodiments relate to a polythiourethane-based plastic lens. When a polythiourethane-based plastic lens is polymerized according to the embodiment, the types, contents, and the like of the polythiol compounds and the isocyanate compounds are adjusted to control the storage moduli at room temperature and high temperatures, their variations, the energy attenuation (KEL) obtained therefrom, and the glass transition temperature, whereby the polythiourethane-based plastic lens thus obtained is enhanced in impact resistance and thermal resistance.

Abstract: A rigid foam including the reaction product of an (poly)isocyanate, and a polyethercarbonate polyol copolymer is described. The polyethercarbonate polyol copolymer is derived from the copolymerisation of one or more epoxides with CO2, wherein the total-CO2— content of the polyethercarbonate polyol copolymer is between 1 and 40 wt %, the carbonate linkages are <95% of the total linkages from the copolymerisation, and the molecular weight is between 100 to 5000 g/mol. The foam is a polyurethane foam, more typically, a polyisocyanurate or a mixed polyisocyanurate/polyurethane foam. Methods, polyols and compositions for producing the foams are also described.

Abstract: Disclosed are polyurethane-foam forming compositions, rigid polyurethane foams and methods for their production, as well as to composite articles comprising such foams sandwiched between facer substrates, including use of such composite elements for floor insulating elements for refrigerated tractor trailers. The rigid polyurethane foams are produced from an isocyanate-reactive composition comprising: (1) a polyol blend; (2) a hydrochlorofluoroolefin; and (3) a tertiary amine catalyst composition.

Abstract: The invention relates to compositions of glycidyl ester used as a stabilizer in polyurethane foams formulations having a good resistance to hydrolysis, improved damping with equivalent or improved physical properties, and high sound absorption capacity. The mono or poly-carboxylic acids glycidyl ester is used in amount of 0.1 to 10 weight % over the polyester polyol resin.

Abstract: The present invention relates to a process for producing a flexible polyurethane foam thermally recyclable by fusion, and to hybrid materials made of flexible polyurethane foam and compact thermoplastic elastomer and/or expanded thermoplastic polyurethane.

Abstract: The present invention provides epoxy resin compounds comprising a high phosphorus and oxazolidone content, methods to prepare these epoxy resin compounds, curable compositions comprising these epoxy resins, and cured epoxy resin compounds by curing the curable epoxy resin compounds comprising a high phosphorus and oxazolidone content.

Abstract: A one-component thermosetting epoxy resin compositions that feature good storage stability. The epoxy resin compositions are especially suitable for use as bodywork adhesive and for production of structural foams.

Abstract: A hot melt epoxy resin system includes an epoxy resin composition and a curing agent/catalyst paste composition that is fast curable, isothermal press curable, hot demoldable capable under three minutes at 150° C. and Class A surface giving and suitable to use in the production of automotive interior composite parts, wherein the epoxy resin composition includes an epoxy resin mixture including a first resin and a second resin; at least one thermoplastic toughener; at least one UV hindered amine light stabilizer; at least one UV absorber and/or blocker; 1,3,5-tris(4-tert.-butyl-3-hydroxy-2,6-dimethylbenzyl)-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione as anti-oxidant; hydrophobic fumed silica as air release/rheology agent and hexamethyldisiloxane as an internal mold release agent and the curing agent/catalyst paste composition comprises a paste mixture, which is comprising dicyandiamide (DICY) below a 10 ?m particle size and sebacic dihydrazide below a 10 ?m particle size.

Abstract: A prepreg comprising: carbon fibers; and a resin composition containing an epoxy resin having a biphenyl structure, a curing agent, and melamine cyanurate.

Abstract: The present disclosure relates to a thermosetting resin composite having a specific thermal stress factor, and capable of implementing a low glass transition temperature, low modulus, and a low coefficient of thermal expansion, and minimizing warpage, and having excellent flowability in a prepreg or semi-cured state, and a metal clad laminate using the same.

Abstract: The present invention relates to a method for the polymerization of cycloolefins by ring-opening metathesis. The reaction is carried out in the presence of at least one particular catalyst, selected from the ruthenium alkylidene complexes comprising at least one 1-aryl-3-cycloalkyl-imidazolin-2-ylidene ligand and mixtures thereof. The invention also relates to a kit for implementing this method.

Abstract: An interpenetrating network (IPN) polymer membrane material includes a soft polyurethane interspersed with a crosslinked conducting polymer. The material can be reversibly “switched” between its oxidized and reduced states by the application of a small voltage, ˜1 to 4 volts, thus modulating its diffusivity.

Abstract: A polyester demulsifier and method of synthesizing said polyester demulsifier including the step of reacting a mixture of polyol and aromatic di-acid, the aromatic di-acid solubilized into said polyol without sublimation or degradation during the reaction process.

Abstract: A production method for obtaining a compound having an amide bond and also having an alkoxysilyl group by a reaction of a compound including a carboxy group with a compound having an amino group and an alkoxysilyl group, the production method comprising: a step of conducting the reaction using a triazine-based amidating agent and under a basic condition.

Abstract: A copolycarbonate optical article comprises a polycarbonate composition including: a copolycarbonate having: 2 to 60 mol % of phthalimidine carbonate units, 2 to 90 mol % of high heat carbonate units, and optionally 2 to 60 mol % of bisphenol A carbonate units. The copolycarbonate has less than 100 ppm of each of phthalimidine, high heat bisphenol, and bisphenol A monomers, and less than 5 ppm of various ions, and is prepared from monomers each having a purity of at least 99.6%. The polycarbonate composition has a glass transition temperature of 200° C. to and a yellowness index of less than 30.

Abstract: A method of producing an oligomer or polymer with carbonate segment chemical structure, the method including the steps of (1) introducing into a reactor high-molecular-weight polyester and reactive oligomer; (2) introducing into the reactor a carbonate compound and a catalyst such that the poly(polyol) reacts with the carbonate monomers by one-pot in situ to produce a crude product; and (3) introducing the crude product into water to obtain an oligomer or polymer with carbonate segment chemical structure. The oligomer or polymer with carbonate segment chemical structure is applicable to automobile manufacturing, wires & cables, and medical equipment.

Abstract: A polycarbonate, a preparation method thereof, and an application thereof are provided. First, an ureido-pyrimidinone type diisocyanate is prepared by a first compound and a second compound. Then, a third compound and the ureido-pyrimidinone type diisocyanate are reacted to obtain a polycarbonate. The polycarbonate replaces scratch resistant metal material to avoid the disadvantages of the signal shielding, heavy weight, and static electricity when using the scratch resistant metal material in the winter. The body housing is made of polycarbonate can have a self-healing property and a good heat resistance, so the internal components can be well protected.

Abstract: A mixture of two alkoxylates surfactants, one being an aryl aliphatic carbinol alkoxylate, the other one being a dialiphatic carbinol alkoxylate, said mixture being useful for stabilizing emulsions and dispersions used in agricultural or pharmaceutical formulations. The alkoxylates surfactants may serve as substitutes for nonylphenol ethoxylates (NPE) and tristyrylphenol ethoxylates (TSE).