Abstract: An apparatus and method for storing medical products such as pharmaceutical and medical products in climate controlled storage devices includes climate control systems in communication with inventory access and tracking systems.

Abstract: A trolley (1), for a beam-mounted supply unit, for fastening medical devices to a ceiling. The trolley has a chassis (2) which can be meshed with a rail track of the beam-mounted supply unit for moving the trolley (1) along the rail track. A medical device can be fastened to the trolley (1). The trolley has a brake unit (3) with at least one braking element (7), which exerts a braking force on the rail track and/or on the chassis in the activated state of the brake unit (3), so that a movement of the chassis along the rail track is at least made difficult compared to an operating state with the brake unit (3) deactivated. In the activated state of the brake unit (3), the braking force exerted by the braking element (7) on the rail track and/or on the chassis is generated without the aid of electric energy.

Abstract: A surgical robotic system comprising: a surgical robot arm (7, 8, 9) having at least six degrees of freedom, the arm having a distal end for attachment to a surgical tool (5) and a proximal end; and a mounting structure (10, 11, 12) configured to mate to the proximal end of the arm for holding the proximal end of the arm spatially fixed, the mounting structure comprising an electrical connection for powering the surgical robot arm; wherein the system comprises a manually operable latching mechanism (6) whereby the arm can be attached to and released from the mounting structure.

Abstract: A method for automatic alignment of a position and orientation indicator with respect to a body part is provided. The method includes the acts of attaching a position and orientation indicator to a body part; moving the body part and measuring movements of the position and orientation indicator; and exploiting physical constraints to motion to determine the alignment of the position and orientation indicator with respect to the body part.

Abstract: Various features for improving the performance of crutches are provided. A crutch can flex at one or more locations or include composite material to provide energy storage and return to the user during ambulation. In some aspects, a crutch is provided that can propel the user forward during ambulation. The crutch can be hollow at one or more locations to allow for increased flexibility and narrower at one or more locations to enhance springiness of the crutch.

Abstract: The apparatus is configured for applying chest compressions to a patient to apply CPR. The apparatus includes a housing configured to mount the apparatus to the patient, a unidirectional motor, and a plunger connected to the unidirectional motor, the plunger configured to apply the chest compressions to the patient when the motor is operated. The apparatus may include a device configured to control a compression distance of compressions. The apparatus is simpler, lighter and eliminates complicated motor control required in prior devices.

Abstract: The disclosed mechanical cardio-pulmonary resuscitation (CPR) apparatuses, systems, and devices have a plunger and a plunger displace sensor that can sense plunger displacement information during reciprocating cycles of the plunger. The disclosure CPR apparatuses, systems, and devices also have a microprocessor unit that can receive sensed plunger displacement information from the sensor and generate plunger driving instructions based on the plunger displacement information. The plunger driving instructions have one or both of a plunger driving force and a plunger amplitude for the reciprocating cycles.

Abstract: An eye moisturizer includes: a pair of hot water containers for storing hot water from which water vapor is generated; a connection panel coupled to the hot water containers to allow the hot water containers to be spaced apart from each other; a glabella support disposed between the hot water containers to maintain a height of a user's face; a lower support protruding from the underside of the connection panel to prevent falling; and water vapor discharge portions formed on tops of the hot water containers or the connection panel to discharge the water vapor therefrom, while preventing the hot water containers from coming into contact with the eyes, where the waver vapor is fed to the eyes seeing vertically the hot water containers and to the skin around the eyes.

Abstract: A syringe comprising a syringe barrel having a distal end, a distal tip, an open proximal end, a barrel sidewall extending between the distal end to the open proximal end and defining a chamber, the barrel sidewall having a barrel sidewall thickness t, the distal end of the syringe barrel including a distal wall is disclosed. The syringe includes a connector integrally formed with and extending distally from the syringe barrel at the distal wall, the connector including a collar disposed coaxially around an elongate tip in fluid communication with the barrel to form a channel between the elongate tip and the collar, the collar including an inside surface, an outside surface and a plurality of ribs extending radially outwardly from the outside surface and separated by spaces, each of the plurality of ribs having a height H and a width W, wherein there is a ratio of the height H to the barrel sidewall thickness tin a range of 0.75 and 1.

Abstract: The automatic pill dispenser is a timing device. The automatic pill dispenser is configured for use with one or more prescription vials. Each of the one or more prescription vials contains a pharmacologically active media. The pharmacologically active media is maintained as a tablet. The automatic pill dispenser comprises a cabinet, a turntable, a storage rack, a dispensing station, a dispensing drawer, and a control system. The control system manages and regulates the operation of the automatic pill dispenser. The turntable and the storage rack stores the one or more prescription vials. The dispensing station and the dispensing drawer count and dispenses one or more doses of pharmacologically active media that are required by a patient.

Abstract: An aromatic pacifier assembly for an infant gives off a predetermined scent by evaporation of volatile essential oils or similar substances. The aroma may be, for example, mint, menthol or eucalyptus, which may help relieve nasal congestion. The aromatic pacifier assembly is constructed to prevent evaporation of the essential oil before activation, so that the nipple does not become contaminated with a flavor the infant may find unpalatable, and so that the oil is conserved until it is desired to administer it to the infant.

Abstract: Oral care compositions and/or unit-dose oral care compositions comprising a high level of surfactant. Oral care compositions and/or unit-dose oral care compositions with a high foaming efficiency. Oral care compositions and/or unit-dose oral care compositions with one or more web forming materials, one or more surfactants, and a sugar alcohol.

Abstract: The invention provides for a topical o/w emulsion having moisturizing, and protecting, repairing or restoring the skin lipid barrier of the lips of a mammal, and is a topical oil-in-water emulsion composition comprising: a discontinuous oil phase; a continuous aqueous phase comprising water; a thickening agent; at least one lamellar membrane structure comprising an alkyl amphiphilic component, an ester of a branched fatty acid and a branched fatty alcohol, a fatty acid, a fatty alcohol, and optionally a phospholipid; and wherein in use the composition has a water vapor transmission rate of less than 65 g·m?2·hr?1 measured in vitro.

Abstract: The present invention is directed to a composition for the conditioning of a dental mineralized surface and/or a dental implant and/or for increasing the hydrophilicity of a dental implant having a metal containing surface. The composition comprises EDTA in a concentration of about 21-55% by weight and hydrogen peroxide at a concentration of about 2-4% by weight. The composition of the invention may be used for the conditioning of mineralized dental surfaces and dental implant surfaces in order to remove e.g. biofilm, debris, bacteria, bacterial toxins etc and/or for increasing the hydrophilicity of an implant having a metal containing surface. The invention is also directed to a kit comprising the composition of the invention and a device to apply the composition to a surface in need of conditioning.

Abstract: Described herein, are personal care compositions comprising a cleanser base comprising at least one cleanser selected from a soap and a surfactant; and an effective amount of an antibacterial system comprising a combination of phenoxyethanol and piroctone, or a salt thereof. Methods of making and using these compositions are also described.

Abstract: A process and composition for improvement of the moisturization state of the stratum corneum of human skin epidermis comprising applying to the skin an effective amount of a composition (C) for topical use comprising at least one cosmetically acceptable excipient and a composition C1 consisting of 20-50% by weight of composition C2, which in turn includes from 3-25% by weight of a polyol, from 25-45% by weight anhydrides of the polyol, and from 30-72% by weight of polyol glycosides of the polyol, with the remainder of composition C2 to 100% by weight being made up of water; and from 50-80% by weight of glycerol and/or glycerol oligomers, with the ratio of polyol glycosides to glycerol and/or glycerol oligomers greater than or equal to 1/10 and less than or equal to 1/2.

Abstract: The invention relates to liquid compositions for use with hair removal devices comprising a methathesized unsaturated polyol ester for improved lubrication.

Abstract: A method of protecting animal tissue particularly skin, from damage caused by radiation exposure, by contacting the tissue with a ketone ester, a method of protecting skin, reducing the deterioration of skin or maintaining or improving the properties of skin by applying topically to the skin a ketone body comprising (R)-3-hydroxybutyrate moieties is disclosed. A ketone body comprising (R)-3-hydroxybutyrate moieties, especially enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate, for such uses is also provided.

Abstract: A method, usage and kit-of-parts for decolorizing human keratin fibers, which were colored with oxidation dyes and/or partially-oxidizing dyes, comprising the application of an agent to the dyed keratin fibers, which contains in a cosmetic carrier at least one compound of the Formula (I) wherein X denotes a bivalent organic radical of the Formula (II) or a direct bond,

Abstract: A novel anti-dandruff agent being a fumagillin derivative according to formula (I), and use of said agent as an anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners. The active is particularly effective against Malassezia yeasts and Malassezia furfur which may cause dandruff. A method of obtaining the fumagillin derivative from culturing of Peyronellaea sp. strain RKDO347 is also described.

Abstract: The present invention relates to: a composition for inhibiting biofilms, containing, as an active ingredient, a peptide derived from human ?-defensin-3; and a method for inhibiting biofilms by using the composition. The peptide according to the present invention inhibits bacterial biofilms even when used alone and exhibits a remarkably increased biofilm inhibitory effect when used in combination with a conventional dental therapeutic agent, and has an effect of preventing a tooth discoloration side effect caused by a conventional dental therapeutic agent.

Abstract: A tooth whitening composition includes a hydrophobic copolymer, a hydrophilic whitening agent and a polar solvent.

Abstract: The instant disclosure relates to hair-treatment compositions. The hair-treatment compositions typically include: one or more polyurethane latex polymers; one or more thickening agents; one or more water-soluble solvents; and water. Additional components such as silicones, emulsifiers, surfactants, cationic polymers, etc., can also be included. The instant disclosure also relates to kits that include the hair-treatment compositions and to methods for treating hair with the hair-treatment compositions.

Abstract: An antiperspirant stick composition can include an amount of a synthetic wax having a melting point less than or equal to 90° C., a melting point additive in an amount sufficient to provide the composition with a melting point greater than or equal to 40° C., an amount of a fatty alcohol, and an effective amount of an antiperspirant active agent. The fatty alcohol and the antiperspirant active agent can be present at a weight ratio of from 2:1 to 1:2.

Abstract: The invention relates to a Truffle extract for skin cosmetic use, comprising compounds having a molecular weight of less than 5 kDa. The invention also relates to a cosmetic method of treatment designed to reduce and/or correct the signs of aging and photo-aging of the skin and keratinous appendages, and to protect the skin against aggressions due to ultraviolet radiation.

Abstract: A method and kit for reconstituting broken fragments of a cosmetic, such as pressed powder cosmetics, are provided which enable a user to recombine or reconstitute such fragments in the original cosmetic packaging. The kit comprises a foamable liquid composition, spreading implement, and at least one pressing implement. Applying embodiments of the foamed liquid composition on fragmented cosmetic material, pressing or packing the mixture comprising the liquid composition and fragmented cosmetic material, and then smoothing the composition by pressing it again within its original casing, in accordance with embodiments of the method, may avoid wasting broken cosmetic fragments and further allows a consumer to use the reconstituted cosmetic for its original purpose.

Abstract: A transdermal composition comprising ibuprofen or salts thereof and a gelling agent which can be used for the treatment of such disorders as pain, inflammation, arthritis, muscle spasm and associated symptoms in humans and animals.

Abstract: The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

Abstract: An edible animal medicine container for delivering medicine or other ingestible material, contained therein, to an animal, includes first and second edible housing shells. The first shell include a first opening defined by a first peripheral ledge having a periphery that is surrounded by a second peripheral ledge that is stepped down from, and connected via a first wall to, the first peripheral ledge. A peripheral lip is disposed around the first wall. The second shell includes a second opening defined by a third peripheral ledge surrounding, and connected via a second wall to, a fourth peripheral ledge which is recessed into the second opening. The first and second shells are positionable into a closed state wherein the first peripheral ledge, the first wall, and the peripheral lip are inserted into the second opening so as to retain the ingestible material within the interior until ingested by an animal.

Abstract: The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent.

Abstract: Drug-delivery systems are described which can serve as platforms for topical delivery of a variety of active pharmaceutical ingredients (API) to the surface of a mammalian body. Methods for the preparation and use of the compositions are also described. In some embodiments, the disclosed topical formulations include an API, a penetration enhancer/cosolvent, a gelling agent, and a neutralizing agent (to adjust pH). As compared to prior compositions, the disclosed topical formulations use a relatively small number of safe components and are easy to prepare with a high yield of finished product.

Abstract: A self-foaming composition for a topical application is described. The composition can include a medium which is cosmetically- or pharmaceutically-compatible with a topical application, and clobetasol propionate. The composition can include a small quantity of foaming surfactants. The composition includes: at least one intermediate composition B including a gas-generating agent; at least one intermediate composition A including an agent for activating the gas-generating agent; and clobetasol propionate being present in at least one of the intermediate compositions A and B. Also described, is a kit or a single container including a plurality of compartments including such a composition.

Abstract: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

Abstract: The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.

Abstract: The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.

Abstract: The present disclosure relates to processes for preparing microparticles using an emulsion process where both a solvent and a salt are used in the continuous phase of the emulsion. The present disclosure also relates to microparticles having an angle of repose of ?35, as measured using a Hele-Shaw cell.

Abstract: An apparatus configured to result in a penetration of one or more gasses into a dermis of biological skin, wherein the apparatus includes a fluid reservoir configured to contain an amount of a liquid in contact with a portion of a person's skin, and a nanobubble generator configured to inject nanobubbles into the liquid, wherein the nanobubbles contain the one or more gasses. The contact of the liquid containing the nanobubbles with the person's skin results in a cutaneous uptake of a gas contained in the nanobubbies into the person's skin, which may be beneficial in treating an ailment, such as diabetic peripheral neuropathy.

Abstract: The present invention relates to disintegratable core/shell silica particles encapsulating a bioactive macromolecule or bioactive macromolecule cluster in an active conformation, a method for producing the same, and uses thereof.

Abstract: The invention relates to biocompatible polysaccharide-based nanocapsule templated on oil core of diameter not exceeding 1 ?m, stabilized without low molecular weight surfactants. The nanocapsule shows long-term stability in an aqueous suspension and is able to highly efficient encapsulation of hydrophobic compounds.

Abstract: The disclosure provides dermal patch formulations that include a pharmaceutically active agent, such as one or more cannabinoids. The formulations can include dihydromyricetin for the purpose of increasing the flux of the pharmaceutical agent into human skin.

Abstract: A wipe containing a fibrous web on which is coated an antimicrobial composition is provided. The composition includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the oil is volatile and tends to evaporate and lose efficacy prior to use, a protein is also employed to enhance the composition's long term stability and antimicrobial efficacy. The protein tends to form a substantially continuous film when coated onto the fibrous web. Because such proteins are typically stiff and brittle, a continuous film would restrict the ability of the fibers to move and bend, reducing web flexibility and drape. Thus, it is typically desired that the antimicrobial composition form a discontinuous coating on the web. In this regard, the present inventors have surprisingly discovered that the addition of an organopolysiloxane can help achieve a discontinuous coating without adversely impacting the ability of the protein to stabilize the oil.

Abstract: The present invention relates to: a muscular atrophy-inducing agent containing, as an active ingredient, a hypometabolism-inducing substance selected from the group consisting of 3-iodothyronamine (T1AM), [D-Ala2,D-Leu5] enkephalin (DADLE), 5?-adenosine monophosphate (5?-AMP), and hydrogen sulfide (H2S); a method for preparing a muscular atrophy study model comprising inducing muscular atrophy by administering the muscular atrophy-inducing agent; a study model prepared by the method; a screening method for a drug for preventing or treating muscular atrophy using the same; a composition for preventing or treating muscular hypertrophy; and a composition for facial muscle shrinkage.

Abstract: Disclosed herein is stable injectable emulsion of Propofol and Ketamine in combination; a base to adjust the pH and purified Lecithin.

Abstract: The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.

Abstract: Compositions of L-4-chlorokynurenic are provided, as are methods for the treatment of neurological dysfunction.

Abstract: The present invention refers to new purified compositions of long chain polyunsaturated fatty acids, or their salts or esters, characterized by being essentially free from other usually present—but structurally different—components, such as furan fatty acids, phytanic and pristanic acids, squalene, and some oligomers, as well as several “persistent” environmental pollutants, such as polychlorinated dibenzo-dioxins and polychlorinated dibenzo-furans, polychlorinated biphenyls, polybrominated diphenyl-ethers, polycyclic aromatic hydrocarbons, and others, which are also usually present and extremely toxic. The invention also refers to the purification method to obtain said compositions and the use thereof as food, food for special medical use, food and diet supplement, and drug.

Abstract: Provided herein are methods of treating an IDH mutant cancer in a subject comprising administering to the subject a therapeutically effective amount of a composition comprising an all-trans retinoic acid (ATRA). In some embodiments, the methods increase an NK-cell-mediated immune response and/or a T cell-mediated immune response to the cancer. In some embodiments, the cancer is a glioma or a chondrosarcoma. In some embodiments, the expression of one or more NKG2D ligands (e.g., ULBP1 and ULBP3) is increased in a tumor microenvironment of the cancer. In some embodiments, CCL2 production, the number of NK cells, and/or apoptosis of tumor cells is increased in a tumor microenvironment of the cancer. In some embodiments, the subject has an IDH1 mutation at arginine 132 or an IDH2 mutation at arginine 172. In some embodiments, method reduces growth of a tumor.

Abstract: Compositions and methods for providing anesthesia to the eye, for treating or preventing inflammatory disorders in the eye, or for treating or preventing ocular infections, are disclosed. The compositions include a glycosaminoglycan, such as hyaluronic acid, in a concentration suitable for achieving a desired viscosity, as well as an active agent, such as an anesthetic, anti-inflammatory, antimicrobial, antiproliferative, antimetabolite, prostaglandin, antioxidant, TGF-beta, or mitomycin C.

Abstract: The present invention relates to a microelement organic O-chelate or N-chelate complex compound, for the inhibition of facultative pathogenic bacteria. The present invention further relates to a composition, feed additive or feed comprising the compounds, as well as methods for the preparation thereof, and for the use thereof in animal stock farming.

Abstract: The invention provides methods of treating an allergic inflammatory condition characterized by inflammation of a squamous epithelium in a target tissue using alpha-1 proteinase inhibitors to replenish SPINK7 protein and/or SPINK7 anti-proteinase activity in the target tissue, and related methods and compositions.