Abstract: A method for creating surgical simulation information by a computer includes creating a virtual body model corresponding to a body state of a patient for surgery, simulating a specific surgical process on the virtual body model to obtain virtual surgical data, dividing the virtual surgical data into minimum surgical operation units, each unit representing one specific operation, and creating cue sheet data composed of the minimum surgical operation units, wherein the cue sheet data represents the specific surgical process.

Abstract: A computing device and a three-dimensional printer are disclosed. Data associated with reference anatomical properties is accessed by the computing device to generate a set of 3D printing files. The 3D printing files are compiled using the computing device to generate a printing model defining an anatomic orientation corresponding to the reference anatomical properties. Printing parameters and materials for the printing model are configured referencing experimentally derived datasets that define predetermined settings for the printing parameters and materials that are suitable for constructing a synthetic anatomical model with properties related to the reference anatomical properties. A synthetic model is printed using the printing parameters and materials as configured. The printing parameters and materials may be modified as desired subsequent to biomechanical testing of the model.

Abstract: In an embodiment, a system attaches a patient reference array of a computer-assisted surgery system to a patient. The system includes a fixation post having a shaft having proximal and distal ends that are offset from. A threaded fastener is coupled to the shaft at the distal end that rotates relative to the shaft so as to engage internal threads of a pedicle screw, thereby causing the distal end of the shaft to translate in the anchor seat and urge the pedicle screw to transition from an unlocked configuration to a locked configuration. The attachment assembly has an arm that supports the patient reference array, and a coupler supported by the arm. The coupler has a fixation body that defines a recess that receives at least a portion of the fixation post, and an actuator that secures the attachment assembly to the fixation post.

Abstract: A tracing device is used for indicating the spatial position of a mechanical arm of a surgical robot. The tracing device includes: a base having two opposite ends and an outer circumferential surface located therebetween, one end is connected to an operation end of the mechanical arm, and a surgical instrument is installed at the other end; and a positioning assembly connected to the base and used for indicating the spatial position of the base. A positioning assembly includes at least three tracing elements arranged on the outer circumferential surface in a non-collinear manner. A plurality of positioning assemblies are distributed in a circumferential direction of the base; and a normal angle between any two of the tracing elements of each positioning assembly is smaller than or equal to 20°.

Abstract: A surgical system is provided. The surgical system includes a camera operable to capture images and/or video. A projector is operable to project light, and a controller is communicatively coupled with the camera and the projector. The controller is operable to track movement of bone in real-time during surgery based on the images and/or video captured by the camera, and control the projector to project the light including a cutting line on the bone to indicate a cutting plane for cutting the bone during surgery.

Abstract: Video editing software tools platform utilizing a video display to provide access to specific video editing software tools, such as video oriented applications or widgets, that can assist those in a video broadcasting team, such as a camera operator or video editor, with a video broadcast feed. Various video editing software tools can provide features and functions that can add visual context to video data presented in the image stream from the video camera and provide archived information pertaining to the same. Various embodiments relate to systems and methods for simultaneously switching input image streams to output devices, while providing optional image processing functions on the image streams. Certain embodiments may enable multiple users/viewers to collaboratively control such systems and methods.

Abstract: A drive interface structure for interfacing one or more drive assembly interface elements of a surgical robot arm and one or more instrument interface elements of a surgical instrument. The drive interface structure includes a sheet of flexible material for providing a barrier between the one or more instrument interface elements and the one or more drive assembly interface elements; and a rigid rim attached to an outer edge of the sheet of flexible material, the rigid rim configured to engage an interface structure for detachably interfacing the surgical robot arm to the surgical instrument so that when the drive interface structure is engaged with the interface structure the sheet of flexible material covers an aperture of the interface structure through which the one more drive assembly interface elements transfer drive to the one or more instrument interface elements.

Abstract: A method for engaging and disengaging a surgical instrument of a surgical robotic system comprising: receiving a plurality of interlock inputs from one or more interlock detection components of the surgical robotic system; determining, by one or more processors communicatively coupled to the interlock detection components, whether the plurality of interlock inputs indicate each of the following interlock requirements are satisfied: (1) a user is looking toward a display, (2) at least one or more user interface devices of the surgical robotic system are configured in a usable manner, and (3) a surgical workspace of the surgical robotic system is configured in a usable manner; in response to determining each of the interlock requirements are satisfied, transition the surgical robotic system into a teleoperation mode; and in response to determining less than all of the interlock requirements are satisfied, transition the surgical robotic system out of a teleoperation mode.

Abstract: A teleoperated system comprises a display, a master input device, and a control system. The control system is configured to determine an orientation of an end effector reference frame relative to a field of view reference frame, determine an orientation of a master input device reference frame relative to a display reference frame, establish an alignment relationship between the master input device reference frame and the display reference frame, and command, based on the alignment relationship, a change in a pose of the end effector in response to a change in a pose of the master input device. The alignment relationship is independent of a position relationship between the master input device reference frame and the display reference frame. In one aspect, the teleoperated system is a telemedical system such as a telesurgical system.

Abstract: A surgical system includes a plurality of voice sensors located in a surgical environment and configured to detect sound and generate a first plurality of signals. The surgical system also includes a position indicator, in proximity to a designated user, configured to indicate a first position of the designated user and generate a second signal representative of the first position. The surgical system further includes a processor configured to receive the first plurality of signals and the second signal and determine, based on the first plurality of signals, a second position. The processor is also configured to compare the detected sound with registered voice command of the designated user stored in a memory to verify the designated user's credentials, and send a command signal to a surgical instrument to carry out an operation related to the voice command based on at least one of the verification of the designated user's credentials, the first position and the second position.

Abstract: A system includes a plurality of manipulators and a controller. The controller is configured to detect mounting of a first imaging device to a first manipulator of the plurality of manipulators, determine a first reference frame for the first imaging device based on the mounting of the first imaging device to the first manipulator, detect mounting of a second imaging device to a second manipulator of the plurality of manipulators, select the first imaging device as a reference imaging device, and in response to selecting the first imaging device as the reference imaging device, control the second imaging device relative to the first reference frame. In some embodiments, the controller is configured to select the first imaging device as the reference imaging device in response to the first imaging device being mounted prior to the second imaging device operator selection or based on a type of the first imaging device.

Abstract: A system for treating a target tissue of a patient comprises a first robotic arm coupled to a treatment probe for treating the target tissue of the patient, and a second robotic arm coupled to an imaging probe for imaging the target tissue of the patient. The system further comprises one or more computing devices operably coupled with the first robotic arm and the second robotic arm, the one or more computing devices configured to execute instructions for controlling movement of one or more of the first robotic arm or the second robotic arm.

Abstract: An articulating structure that bends by relative movement of a plurality of segments connected in series, includes a first segment and a second segment arranged in contact with each other, wherein the first segment has a first front rolling contact surface, and the second segment has a second rear rolling contact surface in line contact with the first front rolling contact surface on a first direction contact line, the first segment has a projection protruding forward from the first front rolling contact surface, and the second segment has a coupling element recessed in the second rear rolling contact surface, wherein the projection is inserted into the coupling element, the first segment and the second segment make a relative rolling movement for translation of the first direction contact line while maintaining the line contact, and the projection supports the first segment and the second segment for the first direction.

Abstract: A medical device and a storage box for a medical article are provided, where the medical device at least includes a main case having at least two exposed chamber outer walls and an accommodation compartment for accommodating a medical article. The at least two exposed chamber outer walls enclose an accommodation chamber to accommodate a functional module. The accommodation compartment is disposed on the main case and adjacent to the accommodation chamber. The accommodation compartment includes at least one exposed compartment outer wall, and the at least one exposed compartment outer wall is connected to the at least one chamber outer wall of the main case. The medical device enables the medical article to be well accommodated in the accommodation compartment, and the accommodation compartment can be flexibly configured onto the medical device to decrease the space occupied by the accommodation compartment.

Abstract: Disclosed is a catheterization package including catheterization-package components and a catheterization tray configured to facilitate a catheterization procedure. The catheterization-package components include a urinary catheter fluidly connected to a urine-drainage bag and a sampling-port access device configured to fluidly connect to a urine-sampling port of the urinary catheter or the urine-drainage bag for aseptic collection of one or more urine samples. The catheterization tray includes at least a first compartment, a second compartment, and a third compartment configured to hold the catheterization-package components. The first compartment is configured to hold the urinary catheter. The second compartment is connected to the first compartment by an intercompartment connection. The second compartment is configured to hold the urine-drainage bag. The third compartment is configured to hold the sampling-port access device.

Abstract: A device (2) for an ophthalmological illumination system (1) comprising a light instrument (3) for illuminating the intraocular space of a human or animal eye (33) comprises a housing (4) having a proximal housing end (5), a distal housing end (6), and an opening (7) in the proximal housing end (5). The housing (4) delimits a receptacle space (8), which extends in a manner proceeding from the opening (7) in the proximal housing end (5) along a longitudinal direction (L) in the direction of the distal housing end (6). The receptacle space (8) is configured for receiving the light instrument (3) through the opening (7) in the proximal housing end (5). The housing (4) comprises at least one translucent material at least in the region (10) of the distal housing end (6).

Abstract: The present disclosure relates to systems and methods for robotic, computer-aided or virtual/augmented reality assisted procedures, including with use a of patient-specific or patient-matched, customized apparatus for assisting in various surgical procedures. In varying embodiments, patient-specific guides may comprise embedded markers, chips, circuits, or other registerable components for providing information to a robotic or computer-aided device. Other apparatus described herein may be aligned and/or matched with the robotic or augmented reality equipment or another apparatus during a surgical procedure.

Abstract: A tracker for a surgical navigation system is provided. The tracker includes one or more markers for determining a position of the tracker and an attachment element configured to releasably attach the tracker to a surgical tool. The attachment element includes an opening for receiving the surgical tool, wherein the opening defines a longitudinal axis. The one or more markers are coupled to the attachment element so as to be symmetrically arranged with respect to the longitudinal axis.

Abstract: A support structure associable with a portion of the human body and usable for supporting a surgical device includes a frame delimiting at least one opening defining an area of surgery, wherein the frame has an upper support portion and a lower portion, means for connecting the frame to the predefined portion of the human body, wherein the connecting means include at least one support operatively connectable, in a removable manner, to the frame and to a predefined portion of the human body, without requiring any percutaneous intervention, and the at least one support is configured for allowing the removal of the frame from the predefined portion of the human body and for providing a reference for the exact repositioning of the frame along the predefined portion of the human body.

Abstract: A curable mixture and method of using the mixture are disclosed. In some embodiments, the mixture comprises a calcium silicate compound, a filler material, a non-aqueous carrier liquid, and a secondary carrier liquid, and has properties suitable for use as a tooth filling after curing.

Abstract: Systems and methods of simulating dental treatments are disclosed. A method may include capturing a first 2D image of a patient's face, including the patient's teeth, building a parametric 3D model of the patient's teeth and gingiva based on the first 2D image, developing a simulated outcome of a dental treatment of the patient's teeth by rendering the parametric 3D model with the patient's teeth in one or more positions and/or orientations corresponding to the treatment goals of the dental treatment plan, and rendering a second 2D image of the patient's face with gingiva and teeth according to a simulated outcome of the dental treatment plan. As noted herein, the dental treatment plan may include orthodontic and/or restorative elements. The simulated outcome may correspond to estimated outcomes and/or intended outcomes of the dental treatment plan.

Abstract: Apparatus, system, and methods for utilizing one or more computing devices to stage the movement of teeth during an alignment treatment are disclosed. The computing device receives an electronic representation of the patient's teeth in their initial position and an electronic representation of the teeth a final position for each tooth. A route each tooth will travel to reach its final position is determined, and the teeth are scheduled to move according to a movement pattern. Moreover, the schedule of movement takes into account a maximum rate of tooth movement for each tooth, the path of movement for each tooth, the distance each tooth needs to move, any needed tooth staggering, any needed round-tripping or tooth movement slowing. The invention also includes techniques for determining an optimum number of stages for the treatment based on the schedule of movement.

Abstract: A method for monitoring the positioning of the teeth including production of a three-dimensional digital initial reference model of the arches of the patient and, for each tooth, definition, from the initial reference model, of a three-dimensional digital reference tooth model; acquisition of updated image of at least one two-dimensional image of the arches in actual acquisition conditions; analysis of each updated image and production, for each updated image, of an updated map; optionally, determination, for each updated image, of rough virtual acquisition conditions approximating the actual acquisition conditions; searching, for each updated image, for a final reference model corresponding to the positioning of the teeth during the acquisition of the updated image, for each tooth model, comparison of the positionings of the tooth model in the initial reference model and in the reference model obtained at the end of the preceding steps to determine the movement of the teeth.

Abstract: The present disclosure relates to shape engineered orthodontic appliances and methods for fabricating the same. Methods of the present disclosure may comprise modifying a first representation of a patient's teeth, wherein the modified representation compensates for a non-elastic deformation resulting from use or wear of the orthodontic appliance. Methods may further comprise defining teeth receiving cavities on the orthodontic appliance, wherein the teeth receiving cavities are shaped to receive and apply a resilient positioning force to the patient's teeth. Methods may also comprise defining exterior portions on the orthodontic appliance using the modified representation of the patient's teeth.

Abstract: A tremor control device comprising a structure positioned within a patient's maxilla that removably engages a patient's maxilla and rigidly maintains the structure in a desired position, a pressure applicator platform rigidly affixed to the structure and positioned under a single trigger point with a surface that removably engages a pressure applicator, and the pressure applicator engages and applies a determined amount of pressure to the single trigger point on a posterior medial gumline of a lingual aspect of the patient's maxilla, where the determined amount of pressure selected is found to reduce the patient's tremors, whereby the structure is placed and secured within the patient's maxilla and the pressure applicator is affixed to the pressure applicator platform whereupon placement of the structure within the maxilla, the pressure applicator engages the single trigger point and applies the determined pressure thereby reducing body tremors.

Abstract: Disclosed is a dental implant with a post element that can be inserted into a jawbone and with a mounting element attached to the post element, to which mounting element and dental element can be affixed with the post element designed as a ceramic body of yttrium and/or aluminum oxide stabilized zirconium oxide. Said dental implant should have an even additionally improved ingrowth or integration behavior during the osseous implant healing, compared with the mentioned known concepts. According to the invention, the surface of the dental implant is provided with at least one partial area that has nanoscopic pore or an otherwise executed nanoscopic structure that has a depletion zone with a reduced yttrium and/or aluminum oxide element, compared with the internal volume.

Abstract: An implant (1) is designed to be fitted in a hole (2a) formed in jaw bone (2) and soft tissue (3). The implant comprises a portion (4b?) to be placed against the upper edge of the jaw bone. Along most of its peripheral extent, the portion (4b?) is provided with groves (9, 9?) or recesses designed to stimulate bone movement and ingrowth (10) of bone. The bone ingrowth (10) forms a barrier against substantial or visible subsidence, around the portion, of the bone (2) with overlying soft tissue (3). The invention permits a good esthetic result and prevents bacteria from penetrating into the internal parts of the implant and of the hole.

Abstract: A dental implant including a core; at least one screw thread; a first and second region; a central axis; the surface of the core defining an angle with the central axis in the first region and with the central axis in the second region; and the surface of the screw thread defining an angle with the central axis in the first region and with the central axis in the second region. The diameter of the core decreases at a rate in the first region towards the apical end such that the core defining angle is greater than the screw thread defining angle, and the diameter of the core decreases at a rate in the second region towards the apical end such that the core defining angle is the same as the screw thread defining angle. Furthermore, an implant including at least one helical chamber including a depth and length.

Abstract: A mold includes a first section, a second section, and a weakened region that joins the first section to the second section. The weakened region is breakable, deflectable, or deformable in response to a first threshold force to enable the first section to be removed from a shell independently of the second section after the shell is formed over the mold. The first threshold force is less than a second threshold force that would damage or permanently deform the shell. The first section is a first mold of at least a portion of one or more first teeth of a dental arch and the second section is a second mold of at least a portion of one or more second teeth of the dental arch.

Abstract: A scannable dental spatial orientation device can comprise a coupling feature operable to couple with a bite plate for supporting a physical dental record material. The scannable dental spatial orientation device can also comprise a body portion having first, second, and third planar faces oriented orthogonal to one another. In addition, the scannable dental spatial orientation device can comprise at least one joint configured for rotating the bite plate and the body portion relative to one another to align the first, second, and third planar faces parallel to a sagittal midline reference plane, a horizontal plane, and a frontal plane of a patient. A dental record optical scan system and a method for digitally recording a maxillary arch position are also disclosed.

Abstract: Systems herein allow a digital assistant to make requests to applications, such as third-party applications, that access data in an enterprise mobility management (“EMM”) system. The digital assistant can link to a portal application and receive a token that identifies a user. A remote application on a user device can establish a session with the portal application as part of a single sign on (“SSO”). The session can identify the same user. The portal application can then link the digital assistant to the remote application. When the digital assistant makes a request to the portal application, a notification can be pushed to the remote application. The user can confirm the request, establishing an authorized session during which time the digital assistant can make additional requests to the portal application. The portal application can service the requests by accessing third-party applications available through the portal application and authorized for access by the SSO.

Abstract: The present invention provides a dental mill blank that exhibits desirable resistance against wear in opposing teeth. The present invention relates to a dental mill blank comprising: an inorganic filler containing an inorganic filler (A) and an inorganic filler (B); and a polymer, the inorganic filler (A) partly forming an aggregate, and the dental mill blank satisfying the following formulae (I) to (III), 0.001?a<0.32??(I) 0.3?b?10??(II) 5?x?80??(III), where a is an average primary particle diameter of the inorganic filler (A) in micrometers, b is an average primary particle diameter of the inorganic filler (B) in micrometers, and x is an average particle diameter of the aggregate in micrometers. Preferably, the dental mill blank comprises an island component containing the aggregate, and a sea component containing the inorganic filler (A) and the inorganic filler (B).

Abstract: The disclosure relates generally to products for dental hygiene. In one embodiment, a toothbrush includes a toothbrush head with toothbrush bristles, a toothbrush handle that is connected to the toothbrush head, and a dental floss dispensing system. The dental floss dispensing system is connected to the toothbrush handle. In other embodiments, a dental floss dispensing system is connected to either a toothpaste tube body or a toothpaste cap of a toothpaste tube.

Abstract: The present invention relates to dental suction devices for capturing aerosols and managing fluid accumulations in a patient's mouth during a dental procedure. The dental suction devices comprise a housing tube having a first end connectible to a vacuum source; a funnel demountably engageable with a second end of the housing tube; a pliable tube extending throughout the housing tube and extending outward from the funnel. The first end of the pliable tube is connectible to the vacuum source and its opposite end is positionable in a patient's mouth. The second end of the pliable tube has a plurality of apertures, and one or more pairs of retaining collars adjustably spaced-apart therealong. The pliable tube may be looped around the end of a row of teeth and secured in place by a tie that is secured to the spaced-apart pair of retaining collars between two adjacent teeth.

Abstract: Disclosed by the present invention are a swing motor and an electronic device, the swing motor comprising a seat; at least two movable members, comprising a first movable member and a second movable member arranged to be spaced apart, wherein the first movable member and the second movable member bear opposite electromagnetic thrusts; elastic support members that correspond one-to-one to the movable members, comprising a first elastic support member and a second elastic support member, wherein the first movable member is mounted onto the seat by means of the first elastic support member, and the second movable member is mounted onto the seat by means of the second elastic support member; further comprised is a twisting elastic member, one end of the twisting elastic member being connected to the first movable member or the second movable member, and the other end being connected to an executing member.

Abstract: Provided is a teeth whitening device. The device includes: a power supply unit supplying power; a light irradiation unit irradiating teeth whitening light by using the power; and an oral wearing unit detachably coupled to the light irradiation unit by a magnetic force and inserted into an oral cavity of a user in use.

Abstract: A stent and a method of deploying thereof, the stent, comprising a main stent configured for deployment in a first passageway; and a limb stent configured for deployment in the main stent and in a second passageway connected to the first passageway; the main stent comprising a constraining septum dividing a lumen of the main stent into compartments, a first one of said compartments being connected to the second passageway.

Abstract: The present invention relates to treating or preventing stenosis at an anastomosis site. In one embodiment, the present invention is a stent is curved along the longitudinal axis for placement in and adjacent to the graft orifice. In a further embodiment, the stent is drug coated to allow delivery of antivasculoproliferative drugs directly to the vicinity of the graft orifice. In a further embodiment, the stent is expandable by use of an external wire. In another embodiment, the present invention is a kit comprising the specially configured stent together with a sleeve comprising a biocompatible matrix material and a pharmaceutical agent, wherein the sleeve is applied to the external surface of the vessel or graft, resulting in extravascular delivery of a pharmaceutical agent. Methods for treating or preventing stenosis at an anastomosis site by applying the extravascular sleeve and the intravascular stent are also provided.

Abstract: The present invention discloses a staged release aortic stent graft, comprising a tubular covering and annular support frames, connectors for a release guide wire to pass through, are arranged axially from the proximal end to the distal end on the covering, and at least two columns of the connectors are arranged axially with spacing. The invention provides a staged release aortic stent graft which can be precisely positioned during release and has high stability during assembly.

Abstract: A soft anchor assembly according to an exemplary aspect of the present disclosure includes, among other things, a sheath and a flexible strand at least partially surrounded by the sheath.

Abstract: A mastopexy implant for maintaining the breast in an elevated and aesthetically pleasing position includes a lower pole support comprising end portions which may be affixed to the chest wall or to a previously installed upper suspension strut. The implant is loaded in an insertion device. The insertion device is inserted through a small incision and into a subcutaneous pocket created in an inferior half of the breast. The lower pole support may have various constructs and in one embodiment includes a unitary conformable mesh having a plurality of arm or band members which are attached across the breast parenchyma and to the chest wall.

Abstract: A method of treating a lens of a patient's eye includes generating a light beam, deflecting the light beam using a scanner to form a treatment pattern of the light beam, delivering the treatment pattern to the lens of a patient's eye to create a plurality of cuts in the lens in the form of the treatment pattern to break the lens up into a plurality of pieces, and removing the lens pieces from the patient's eye. The lens pieces can then be mechanically removed. The light beam can be used to create larger segmenting cuts into the lens, as well as smaller softening cuts that soften the lens for easier removal.

Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.

Abstract: Apparatus for treating blood flow regurgitation through a native heart valve (16) includes a selective occlusion device sized and configured to be implanted in the native heart valve (16) and selectively operating with at least one of the first or second native leaflets (16a, 16b) to allow blood flow through the native heart valve (16) when the heart cycle is in diastole and reduce blood flow regurgitation through the native heart valve (16) when the heart cycle is in systole. A clip structure (50) is coupled with the selective occlusion device. The clip structure (50) is configured to be affixed to a margin of at least one of the first or second native leaflets (16a, 16b) to secure the selective occlusion device to the native heart valve (16).

Abstract: Systems and methods for medical interventional procedures, including approaches to valve implantation. In one aspect, the methods and systems involve a modular approach to mitral valve therapy.

Abstract: A transcatheter valve prosthesis includes a stent and a prosthetic valve disposed within the stent. The stent is balloon expandable and includes an inflow portion, an outflow portion, and a transition portion extending between the inflow portion and the outflow portion. A diameter of an inflow end of the transcatheter valve prosthesis is greater than a diameter of an outflow end of the transcatheter valve prosthesis. The transcatheter valve prosthesis has a tapered profile along an entire height thereof when in the stent is in the expanded configuration. The inflow end of the transcatheter valve prosthesis is configured to sit within and contact an aortic annulus of the native aortic valve and the outflow end of the transcatheter valve prosthesis being configured to float within an ascending aorta without contacting the ascending aorta due to the tapered profile of the transcatheter valve prosthesis.

Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.

Abstract: A replacement heart valve has an expandable frame configured to engage a native valve annulus and a valve body mounted to the expandable frame. The valve body can have a plurality of valve leaflets configured to open to allow flow in a first direction and engage one another so as to close and prevent flow in a second direction, the second direction being opposite the first direction.

Abstract: The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support, a prosthetic valve assembly within the valve support, and an anchoring member having an upstream portion and a downstream portion. The device further includes an extension member coupled to the fixation frame and extending radially outward therefrom. The extension member includes a plurality of wires, at least a portion of which include an inner core surrounded by an outer material. The wires include a plurality of recesses extending through at least a portion of the thickness of the outer material, and a therapeutic agent in the recesses for delivery to the anatomy when the prosthetic heart valve device is positioned at a native annulus.

Abstract: A method and device for treating mitral regurgitation includes providing a treatment device comprising an expandable frame, and a leaflet assembly housed inside the frame. The frame has a tenting element. The treatment device is delivered to the aortic position in a patient's aortic valve, and the frame is expanded at the location of the native aortic valve, with the tenting element pushing the aortic curtain and/or anterior leaflet and/or mitral annulus of the mitral valve towards the mitral valve direction. The leaflet assembly replaces the valve function of the patient's native aortic valve.