Abstract: A sensor device which is adapted for detecting target molecules in-vitro and in-vivo, comprises a MIR source for exciting the target species and a probe beam with split frequency to measure the effect of excitation. The latter uses a heterodyne interferometer operating at a beat frequency ˜ KHz. to MHz. The photo-thermal excitation of target species leads to refractive index change. The RI change produces probe beam displacement and is measured using a 1) grating heterodyne interferometer, 2) grating deflection amplifier and 3) evanescent field heterodyne interferometer. The measured RI change can be related to specie concentration change in target volume. Furthermore, a sensing method for detecting HbA1c concentration and its change with thermal excitation is described in terms of phase shift of the OCT spectrum obtained with spectral domain optical coherence tomography (SD-OCT).

Abstract: An endoscope system includes: an image acquiring unit that acquires a first frame image obtained by photographing a photographic subject and a second frame image obtained by photographing the photographic subject at a timing different from that of the first frame image; an oxygen saturation calculating unit that calculates an oxygen saturation by using the first frame image and the second frame image; a reliability calculating unit that calculates reliability of the oxygen saturation, calculated by the oxygen calculating unit, by using a signal ratio that is a ratio between a pixel value in a first specific wavelength range corresponding to a specific wavelength range of the first frame image and a pixel value in a second specific wavelength range corresponding to the specific wavelength range of the second frame image; and an information amount adjusting unit that adjusts an information amount of the oxygen saturation by using the reliability.

Abstract: Independent component analysis may be performed on a plurality of detected electronic signals to separate signals within the detected electronic signals that are contributed by different sources. Each of the plurality of detected electronic signals may be received from a separate detector and may correspond to a detected optical signal emanating from a pregnant mammal's abdomen and a fetus contained therein. The detected optical signals may correspond to light that is projected into the pregnant mammal's abdomen from a light source. The separated signals may be analyzed to determine a separated signal that corresponds to light incident upon the fetus, which may be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus. An indication of the fetal hemoglobin oxygen saturation level may then be provided to the user.

Abstract: A lab-on-skin biosensor for detecting target molecule and vital sign monitoring, a method of manufacturing, and a method of using the same, wherein the lab-on-skin biosensor is fabricated with a microfluidics layer, a moisture resistant layer, a multimodal sensing layer comprising an electrode, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds having metal chelating moieties that reduce degradation of the analyte indicator.

Abstract: A system may include a first device and a second device. The second device may be configured to execute an application and validate that the application is able to cause the second device to (i) communicate with the first device and (ii) communicate with a user of the second device. The second device may be configured to (a) check one or more settings of the second device and/or (b) convey a request for data to the first device and determine whether the second device receives the requested data. The second device may be configured to cause the second device to display a message requesting confirmation that the second device displayed the message and determine whether the second device receives the requested confirmation that the second device displayed the message.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: The technology relates to medical devices for monitoring and assessing vascular health. In one embodiment, the technology is an apparatus that attaches to a subject's finger comprising a heating and cooling component, a coherent source, a temperature sensor, an image detector, and/or a component for data control and management. In another embodiment, there is a component that alters local blood flow in the subject, and laser speckle contrast and photoplethysmography (PPG) signals from the altered blood flow in the subject are compared to monitor the vascular health of the subject.

Abstract: The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

Abstract: There are provided a blood-collecting device by which a blood-collecting operation can be performed by single hand and the blood can be collected in a short time without a risk of hemolysis, and a blood-collecting tube usable for blood-collecting device. A blood-collecting tube, of which a tip portion is housed in a tube holding portion and which accommodates the blood coming out of a base end side of a needle tube, includes a tube structure opened at both ends, and a tube attached to the tube structure. A tip portion of the tube structure is housed in a hollow portion of a tube holding portion of a needle base. The tube preferably has elasticity. The tube is attached to the tube structure using elastic deformation of the tube, allowing the tube to be in close contact with an inner circumferential surface of the needle base.

Abstract: An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir.

Abstract: A whole blood filtration device is provided with a filter membrane separating a feeding volume and a clean side of the filter membrane from each other. The feeding volume communicates with a first feeding side opening and with a second feeding side opening. The filter membrane has pores with a pore size that ensures permeability of the filter membrane to blood plasma/serum and that retains blood cells. The first feeding side opening can be coupled to a first blood pump for feeding blood from the first feeding side opening into the feeding volume so that blood plasma/serum permeates the filter membrane and blood cells, retained by the filter membrane, exit from the feeding volume through the second feeding side opening.

Abstract: A biological fluid collection system that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection system of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection system of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.

Abstract: A sleepiness estimating device includes a biometric information acquirer that acquires biometric information of a person, an auxiliary information acquirer that acquires auxiliary information including at least one of five-sense information perceived by the person or emotion information indicating an emotion of the person, and a sleepiness estimator that estimates a sleepiness of the person based on the biometric information and the auxiliary information.

Abstract: Example aspects of a collector for a seizure detection device, a seizure detection device, and a method of detecting a seizure are disclosed. The collector for a seizure detection device can comprise a collector material configured to collect volatile organic compounds given off from a patient's skin; a wrapping configured to isolate the collector material from an external environment; a heater comprising a heating element, the heating element configured to emit a thermal pulse to desorb the volatile organic compounds from the collector material; and a mesh layer configured to prevent the collector material from contacting the patient's skin, wherein the collector material is received between the wrapping and the mesh layer.

Abstract: The present invention relates to a parathyroid sensing system, and includes: a modulator for generating a modulation signal having a predetermined frequency; a lock-in amplifier and a light source which receive information on the modulation signal; an excitation filter for transmitting, among light emitted from the light source, only excitation light that excites parathyroid glands; an emission filter connected to a probe and selectively transmitting only fluorescence emitted from the parathyroid glands; a near-infrared sensor for sensing the autofluorescence that has passed through the emission filter, and converting the sensed autofluorescence into an electric signal; and a speaker for generating an alarm through the electric signal. Through the present invention, the locations of the parathyroid glands may be precisely identified even when lights are turned on in an operating room, and convenience may be provided by alerting a surgeon by means of an alarm when the parathyroid glands are detected.

Abstract: A system for tracking a bone-altering tool in computer-assisted surgery, comprising a first trackable reference secured to a first bone, with a first frame of reference being associated with the first trackable reference. A bone-altering tool is securable to the first bone in a secured configuration. Sensors track the trackable reference for position and orientation. A position/orientation calculator is connected to the sensor device to calculate a position and orientation of the first frame of reference. An alteration parameter calculator is associated with the position/orientation calculator to determine a position and orientation of the bone-altering tool in the secured configuration as a function of the position and orientation of the first frame of reference and of the secured configuration. A method for tracking tools using the tracking of a bone is provided.

Abstract: An initial level of the sleep sufficiency levels is determined from the maximum sleep duration and an ordinary sleep duration of the person to be examined, evaluation on the ordinary sleep duration of the person to be examined himself/herself, or data obtained from persons of her than person to be examined. The sleep sufficiency level estimation section calculates an increase/decrease of the sleep sufficiency level corresponding to the sleep duration of the person to be examined by using a function selected according to characteristic data indicating characteristics of the person to be examined obtained from the person to be examined and the sleep duration zone to which the sleep sufficiency level of the person to be examined belongs. The sleep sufficiency level estimation section estimates the sleep sufficiency level of the person to be examined by using the calculated result.

Abstract: Sensing circuitry of an implantable medical device (IMD) system may sense a cardiac signal that varies according to a cardiac cycle of a patient. Processing circuitry of the IMD system may determine a series of consecutive cardiac cycle length metric values based on the sensed cardiac signal, identify a plurality of pairs of the cardiac cycle length metrics, each of the pairs of cardiac cycle length metrics separated by an integer ‘n’ of the cardiac cycle length metrics, and construct a distribution of the pairs of cardiac cycle length metrics based on values of the cardiac cycle length metrics for each of the pairs. The processing circuitry may detect a sleep apnea episode of the patient based on one or more characteristics of the constructed distribution, and control communication circuitry of the IMD system to transmit an indication of the detected sleep apnea episode to the external computing device.

Abstract: An example of a system for managing pain may include a pain monitoring circuit, a pain relief device, and a control circuit. The pain monitoring circuit may include a parameter analyzer and a pain score generator. The parameter analyzer may be configured to receive and analyze at least two parameters selected from a physiological parameter indicative of a physiological function or state of a patient, a functional parameter indicative of a physical activity or state of the patient, or a patient parameter including subjective information provided by the patient. The pain score generator may be configured to compute a composite pain score using an outcome of the analysis. The composite pain score may indicate a degree of the pain. The pain relief device may be configured to deliver a pain-relief therapy. The control circuit may be configured to control the delivery of the pain-relief therapy using the composite pain score.

Abstract: Devices and methods for detecting meal intake are disclosed herein. In some embodiments, one or more sensors can be used to detect or monitor physiological parameters of a user (e.g., heart rate, body movements, temperature, pH, impedance, gastric stretch, sound emissions, and the like). The outputs of the sensors can be received by a computer system configured to analyze the sensor data and make a determination as to whether meal intake has occurred or is presently occurring. The computer system's determination can be used to trigger, modulate, or otherwise control one or more therapeutic devices. Other types of devices can also be controlled using this determination, such as monitoring or logging devices.

Abstract: Modular physiological sensors that are physically and/or electrically configured to share a measurement site for the comfort of the patient and/or to ensure proper operation of the sensors without interference from the other sensors. The modular aspect is realized by providing outer housing shapes that generally conform to other physiological sensors; mounting areas for attachment of one sensor to another sensor; providing release liners on the overlapping sensor attachment areas; and/or providing notches, tabs or other mechanical features that provide for the proper placement and interaction of the sensors.

Abstract: A flexible photonic skin is provided, including a functional layer, an adhesive layer used for fixing the functional layer and made of hypoallergenic polyvinyl ethyl ether, and a packaging layer made of a polyurethane semi-transparent film and adhered to the adhesive layer, which are arranged successively from the top down, wherein the functional layer consists of two electrodes located on two sides and used for acquiring electrocardiographic signals of a human body, and a polymer-based photonic integrated chip located between the two electrodes and used for acquiring body temperature, pulse, blood pressure and blood glucose signals of the human body; and, the polymer-based photonic integrated chip processes and outputs the acquired electrocardiographic signals of the human body as well as the body temperature, pulse, blood pressure and blood glucose signals of the human body.

Abstract: A simple, disposable sensing device for sensing an analyte is housed in a single case. The sensing device can transmit sensor data to monitoring device(s). The sensing device includes: a case having a lower major wall adapted to be mounted against a patient's skin, and an upper opposing major wall; a sensor extending from the case and having a distal end sensitive to the analyte to produce an electrical signal, and a proximal end within the case having electrical contacts; a printed circuit board assembly within the case supported by one of the major walls to receive the electrical signal via the electrical contacts; and an elastomeric pad disposed in the case and biased by the other major wall to urge the proximal end of the sensor into contact with the printed circuit board assembly and maintain an electrical connection between the electrical contacts and the printed circuit board assembly.

Abstract: Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for assessing collateral ventilation. An illustrative embodiment includes an occlusion device insertable into a bronchial passageway to selectively seal the bronchial passageway to occlude a lobe of a lung. A flow lumen sealably extends through the occlusion device to a distal end and has a proximal end receptive of a positive pressure flow. A check valve is coupleable with the flow lumen to permit the positive pressure flow to pass to the distal end of the flow lumen and prevent a backflow of pressure from the flow lumen. A flow meter is couplable with the flow lumen to measure the positive pressure flow through the flow lumen. The occlusion device is insertable into the passageway to the isolated lobe. Measurements of the flow meter of the positive pressure flow into the occluded lobe are monitorable to assess collateral ventilation from the occluded lobe.

Abstract: An annular mapping catheter includes a catheter body. The catheter body has a distal end and a proximal end. The distal end of the catheter body is provided with a distal end assembly, and the proximal end of the catheter body is provided with a handle. The distal end assembly is made of a head end catheter that has a shape memory function. The distal end assembly in a free state presents a predetermined bent shape including an annular part and a vertical part. The vertical part connects the annular part to the catheter body. The distal end assembly is provided with an electrode. The annular mapping catheter can detect an electrocardiogram activity near a pulmonary vein ostium and can better locate a cryoballoon in the heart.

Abstract: The present disclosure provides an electrophysiology system to facilitate visualizing a proximity of at least one catheter electrode to a 3D geometry of a biological tissue. The system includes a computing device including at least one processor in communication with a memory, wherein the processor is configured to determine the proximity between the at least one catheter electrode and the biological tissue using at least one measurement. The system further includes a display device configured to display the 3D geometry of the biological tissue and a visual effect illustrating the proximity between the at least one catheter electrode and the biological tissue.

Abstract: There is disclosed a method of extracting large scale biological, biochemical or molecular information about an index disease, biological state, or systems from imaging by correlating the imaging features associated with said disease, state or system with corresponding large scale biological data.

Abstract: Apparatuses and methods for the prevention of bodily injuries through active monitoring of bodily postures, supporting a body while in or restricting a body from entering predetermined postures which heighten the body's susceptibility to injury, and alerting one or more entities (e.g., an apparatus user) of a body's susceptibility to injury is disclosed herein. In one embodiment, the method may include one or more operations including monitoring one or more bodily postures and/or bodily movements, storing data associated with bodily postures and/or bodily movements, determining a risk of injury associated with bodily postures and/or bodily movements, and alerting one or more entities when a risk of injury associated with bodily postures and/or bodily movements reaches a predetermined level.

Abstract: In one embodiment of the invention, an interactive vital signs scanning method is disclosed including concurrently scanning for a plurality of vital signs with a portable vital signs scanner; detecting movement of the portable vital signs scanner during the scanning for the plurality of vital signs; and determining a measure of quality of the scanning for the plurality of vital signs with the portable vital signs scanner. In another embodiment, a method of improving the quality of vital signs data is disclosed including concurrently sensing data from a plurality of vital signs sensors over a period of time with a portable vital signs scanner; determining a plurality of vital sign values for a respective plurality of vital signs in response to the sensed data from the plurality of vital signs sensors over the period of time; and fusing at least two vital sign values of the plurality of vital sign values for the respective plurality of vital signs.

Abstract: A system for clinical decision support for a caregiver during a clinical encounter involving respiratory distress includes a defibrillator/patient monitor including sensors configured to gather patient physiological data, a user interface device, a memory, and a processor communicatively coupled to the defibrillator/patient monitor, the memory, and the user interface device and configured to control the user interface device to display diagnosis and treatment pathways (DTPs) comprising a respiratory distress DTP, receive a user selection of the respiratory distress DTP; control the user interface device to provide at least a portion of the physiological data in response to the user selection of the respiratory distress DTP, provide a suggested respiratory distress diagnosis at the user interface device based on the physiological data and the user selection of the respiratory distress DTP, and provide a respiratory distress treatment protocol at the user interface device based on the suggested respiratory dist

Abstract: Methods for determining the likelihood that a subject will be a placebo responder in a clinical study are provided. Also provided are methods for eliminating likely placebo responders from a clinical study a priori, thereby simplifying data analysis and minimizing or eliminating any confound that arises in the analysis as a result of placebo response. Databases and computer systems using the methods are also disclosed herein. Methods for assessing likelihood of a subject experiencing a response shift are also provided.

Abstract: A breast compression paddle for use in an imaging system includes a compression surface and a jacket. The jacket includes at least one inflatable chamber disposed adjacent to the compression surface and a sheet covering at least a portion of the compression surface. The at least one inflatable chamber is configured to selectively inflate and induce the sheet to slide along the compression surface.

Abstract: The front wall of an imaging system breast compression paddle is adjacent to and faces a patients chest wall during imaging. The front wall has a reference surface adjacent to the chest wall. The bottom wall which is connected to a curved lower interface extends away, from the chest wall and is adjacent to the top of a compressed breast. Two outer edges which extend away from the front reference surface, partially define a slightly raised central portion of the bottom wall. A bottom reference plane, a vertical reference plane substantially orthogonal to the front reference surface and the bottom reference plane, and an access surface disposed proximate at least one of the two outer edge portions are each defined by the bottom wall. The access surface is non-orthogonal to the front reference surface, the bottom reference plane, and the vertical reference plane.

Abstract: In order to reduce a radiation dose delivered to an object or an observer, a facility for monitoring handling of the object has an optical unit configured to direct ionizing radiation onto the object and also a filter element in order to attenuate a part of the ionizing radiation. An imaging unit may detect portions of the ionizing radiation passing through the object in order to create an image of the object. A view acquisition system may acquire a viewing movement, and a control unit is configured, during a first operating mode, to control a position of the filter element as a function of the viewing movement. The control unit is configured to identify a predefined sequence of viewing movements and, as a function thereof, to switch into a second operating mode. The position of the filter element is controlled during the second operating mode as a function of an image analysis.

Abstract: An X-ray imaging apparatus includes an X-ray irradiation region adjustment unit for adjusting an X-ray irradiation region and a control unit for controlling the X-ray irradiation region adjustment unit so as to adjust the X-ray irradiation region based on a set region of interest in the case of a region of interest highlighting mode that highlights a predetermined target object within the region of interest set in the image generated by by the image processing unit.

Abstract: A radiation image capturing apparatus is provided. The apparatus comprises pixels, drivers to which row signal lines for driving the pixels for each row are respectively connected and a controller. The controller supplies, before radiation irradiation, selection signals to a driver group constituted by not less than two drivers which drive detection pixels, of the pixels, to cause each of the drivers included in the driver group to select a row signal line to which the detection pixels are connected, and the controller supplies, during radiation irradiation, a drive signal for driving pixels connected to a row signal line selected from the plurality of row signal lines to each driver included in the driver group to cause the radiation image capturing apparatus to acquire a signal for measuring a dose of radiation entering from each of the detection pixels.

Abstract: A method of operating a digital radiographic imaging system includes capturing a digital radiographic image of a subject anatomy and automatically placing a digital anatomical marker therein. The radiographic image is displayed to an operator, the operator confirming a position of the automatically placed digital anatomical marker by storing the radiographic image or by repositioning the marker and storing the radiographic image.

Abstract: An image processor applies computation processing to a plurality of CT images formed by irradiation of radiation of a plurality of energy levels to acquire monochromatic CT images. The image processor acquires a first energy level CT image formed by irradiation of first energy level radiation and a second energy level CT image formed by irradiation of second energy level radiation, applies a plurality of weighted computations to the first and second energy level CT images to compute a plurality of monochromatic CT images as a result of the weighted computations, segments a surrounding region of a highly-absorbent material circumferentially into a plurality of regions of interest having a predetermined area and calculates a standard deviation of the surrounding region by using a mean value of image data of each region of interest, for each monochromatic CT image, and selects a monochromatic CT image with a small standard deviation.

Abstract: Abnormalities of blood vessels associated with brains of individuals can be detected by analyzing images that include the brains of the individuals. Blood vessels included in the images can be identified and densities of blood vessels across hemispheres can be determined. Differences between densities of blood vessels in different hemispheres of the brains of the individuals can be used to determine a probability of an abnormality with respect to one or more blood vessels associated with the brains of the individuals. User interfaces can be generated indicating possible abnormalities associated with the brains of the individuals.

Abstract: A system for radiographic tissue density evaluation includes a cassette for exposure to an X-ray source, where the cassette is configured to obtain information to perform intensity standardization of a captured radiographic image of a subject, a calibration bar with a predetermined radiographic signature on or within the cassette to serve as reference for performing the intensity standardization, and a software program to perform analysis on and to provide a display of the captured radiographic image. The cassette also includes a radio-opaque backing with a spatial homogenous X-ray radiographic signature used to estimate a source-detector geometrical inhomogeneity.

Abstract: The invention provides, in some aspects, a system for implementing a rule derived basis to display volumetric image sets. In various embodiments of the invention, the selection of the images to be displayed, the generation of the 3-D volumetric image from measured 2-D images including the rendering parameters and styles, the choice of viewing directions and 2-D projection images based on the viewing directions, the layout of the projection images, and the formation of a video can be determined using a rule derived basis. In an embodiment of the present invention, the user is presented with sequential images making up a video displayed based on their preferences without having to first manually adjust parameters. The present invention allows for novel ways of viewing such images to detect microcalcifications and obstructions when reviewing Digital Breast Tomosynthesis and other volumetric mammography images.

Abstract: A two-dimensional image acquisition unit acquires a plurality of two-dimensional images generated from a three-dimensional image of a patient in a case where an observation target is viewed from a plurality of different viewpoints, and a surface data acquisition unit acquires surface data of each of a plurality of structures on the patient from the three-dimensional image. A composite image generation unit generates a composite image in which a composite target image generated from the surface data and the two-dimensional image are composed, and a display switching control unit receives an operation of displaying or non-displaying any of the structures and performs display by switching between the composite image of the composite target image and the two-dimensional image corresponding to the structure to be displayed and the two-dimensional image of the structure to be non-displayed.

Abstract: Method of data processing for Computed Tomography from a spectral image data set of an imaged zone, an anatomical image data set of the imaged zone, and an anatomical model, comprising: a. Assigning an initial set of values to a regularization scheme, 5 b. Performing a noise reduction scheme on the spectral image data set, wherein said noise reduction scheme is a function of the regularization scheme, of the spectral image data set and of the anatomical image data set, in order to obtain a processed spectral image data set, c. Performing a segmentation of structures of interest using the anatomical data set, the processed spectral image data set, and the anatomical model, in order to obtain a segmentation result, d. Updating the regularization scheme based on the segmentation result, e.

Abstract: A digital radiographic image of a subject is captured using a reduced exposure level of an x-ray source. One or more exposure control regions in the image is mapped and associated with a predetermined exposure level. A difference between the predetermined exposure level setting and the reduced exposure level is used to set a diagnostic exposure level perhaps about twice as high as the reduced exposure level to capture a diagnostic image of the subject.

Abstract: Methods and systems are provided for dual energy imaging. In one embodiment, a method for a dual energy imaging system comprises determining a first tube potential and a second tube potential according to a size of a subject, and controlling the dual energy imaging system with the first tube potential and the second tube potential to generate lower energy x-rays and higher energy x-rays respectively to image the subject. In this way, image quality may be increased while minimizing dose during dual energy imaging of a particular imaging subject.

Abstract: A three-dimensional phantom for providing displacement profiles for a CT table having 6 degrees of freedom includes a body having at a top face, a side face and an end face; the top face and the side face sharing a common edge; the top face and the end face sharing a common edge; and the side face and the end face sharing a common edge; wherein an angle formed by the top face and the end face is less than 90 degrees; the side face including a first isocenter mark and a first offset mark, wherein the first offset mark has an angle corresponding to the angle formed by the top face and the end face; and an isocenter marker at the isocenter of the body.