Abstract: Method for wide range gas detection using a gas detection system comprising a sample gas inlet, a reference gas inlet, a gas modulation valve and a gas analyzer, wherein the gas modulation valve alternatingly connects the sample gas inlet to the gas analyzer during a sample gas time period and the reference gas inlet to the gas analyzer during a reference gas time period, characterized in that the sample gas time period is shorter than the reference gas time period such that the sample gas concentration in the gas analyzer is reduced.

Abstract: An air quality measurement system for a plurality of adjacent ground flares. The system includes a plurality of unmanned aerial vehicles operating aerially above and around emissions from a plurality of adjacent ground flares. Sensors mounted on each of the plurality of unmanned aerial vehicles monitor atmospheric air properties. A data central processing unit receives, collects, and analyzes data from each of the sensors on each of the unmanned aerial vehicles regarding the atmospheric air properties.

Abstract: Disclosed herein is a method of detecting faults beneath a construction supported by earth. The method comprises detecting the conditions of fabric built into the construction supported by earth. One condition of the fabric indicates a fault while a second condition indicates no fault. The detected condition is associated with the location of the fabric that was built into the construction. The detected condition of the fabric is reported. Also disclosed is a fabric that can be included when constructing a road or similar construction such as a highway, railway, runway or dike. The fabric is an array of electronic circuits such that stretching or tearing said fabric will damage electrical characteristics of the fabric. An apparatus for detecting faults beneath a road is also disclosed. The apparatus comprises a fabric built into the road, and a sensor apparatus configured to measure conditions of the fabric at multiple locations. A subset of the conditions of the fabric indicates faults beneath the road.

Abstract: Methods are provided for predicting the properties of an asphalt emulsion, such as an asphalt emulsion that contains an asphalt fraction derived from a plurality of crude oils. Corresponding tools are provided to allow for visualization of the predicted asphalt emulsion properties. The properties of the asphalt components in an asphalt fraction for forming an emulsion can be represented based on using a simplified functional form to represent each emulsion property of each asphalt component. The emulsion properties of an asphalt fraction, composed of a plurality of asphalt components, can be modeled based on a linear combination of the emulsion properties of the asphalt components.

Abstract: A system for molecular mapping includes a semiconductor substrate defining a reservoir to receive a sample of molecules and a nanofluidic channel in fluid communication with the reservoir. The system also includes a plurality of electrodes, in electrical communication with the nanofluidic channel, to electrophoretically trap the sample of molecules in the nanofluidic channel. At least one avalanche photodiode is fabricated in the semiconductor substrate and disposed within an optical near-field of the nanofluidic channel to detect fluorescence emission from at least one molecule in the sample of molecules.

Abstract: Provided herein are compositions, compounds, processes, and methods of use of 3D porous coating(s) on or near a nanopore(s) for analysis or detection of charged polymers such as nucleic acids, proteins, protein-nucleic acid complexes, small molecule-biological complexes, polymer-biological complexes, and/or polyelectrolytes.

Abstract: The biological information detection sensor supply device is provided with a main body case having a supply port to which a biological information measurement device can be attached, a housing unit for housing a biological information detection sensor and a sensor supply film including a cover film and a holding film for sandwiching the biological information detection sensor, and a supply unit for supplying the biological information detection sensor from the housing unit to the supply port. The supply unit supplies the biological information detection sensor to the supply port, and separates the holding film and the cover film from the sensor supply film in a state before the biological information detection sensor is supplied to the supply port. At the supply unit, the biological information detection sensor supplied to the supply port is fitted to the biological information measurement device fitted to the supply port.

Abstract: Anew cell line and an antibody for determining the activity of botulinum toxin are disclosed. Also disclosed is a method of determining the activity of botulinum toxin using the cell line and/or the antibody.

Abstract: An analysis device includes a turntable, an optical pickup, and a controller. The turntable holds a specimen analysis disc having reaction regions on which nanoparticles binding to substances to be detected are captured. The optical pickup emits laser light to each reaction region, receives a reflected light from each reaction region, and generates a light reception level signal. The controller sequentially generates a plurality of measurement gate signals for counting the number of the nanoparticles captured on each reaction region, counts the number of the nanoparticles of each of the measurement gate signals based on the light reception level signal, specifies a measurement gate section in each reaction region according to a measurement result per measurement gate signal, and adds up the number of the nanoparticles of the respective measurement gate signals in the measurement gate section.

Abstract: The present invention relates to a method for detecting an analyte in a sample, comprising the steps of: forming on each of carrier particles a complex containing a first capture substance capable of binding to an analyte, one molecule of the analyte, a second capture substance capable of binding to the analyte, and a catalyst; immobilizing a reaction product on each of the carrier particles by reacting the catalyst in the complex with a substrate; and detecting the analyte by detecting the carrier particles on each of which the reaction product is immobilized.

Abstract: The invention relates to methods for binding biologically active molecules to surfaces by coating the surface with a supported reagent in a first step and then covalently coupling said biologically active molecules to the supported reagent using a biorthogonal cycloaddition reaction. Fields of application of the invention include biochemical research, medical diagnostics and the pharmaceutical industry.

Abstract: The present invention relates to detecting cleavage activity of an enzyme. The various aspects of the invention include an enzyme detection device, kit, method and use for detecting or measuring the presence in a test sample of the activity of an enzyme capable of cleaving a substrate. The invention also relates to indicator and binding molecules useful for carrying out the invention. The enzyme substrate contains a hidden binding site which is only revealed upon cleavage by the enzyme.

Abstract: Disclosed is an ultrahigh-sensitivity two-dimensional chromatography-based biosensor, wherein cross-flow of high driving force across a narrow membrane is applied, thereby enabling the elimination of background noise, efficient supply of a large-sized polymeric or high-molecular-weight signal tracer, sequential material supply for increased reactivity, and simultaneous washing and signal generation when additional signal generation is required, as in an enzyme.

Abstract: A method of detecting the presence or absence of alpha methylacyl A coenzyme racemase (AMACR) is provided. In one embodiment of the method, a fluid including a secretion chosen from at least one of a prostate secretion or a secretion from an accessory glad or a cellular component of the fluid is obtained from a subject. The fluid is contacted with a reagent for detecting AMACR under conditions such that the reagent detects AMACR in the semen. The level of AMACR is determined such as by comparing it to a standard curve. The fluid can be semen or a prostate secretion or another fluid. A kit that can be used with the method is also provided.

Abstract: The present disclosure provides methods of using certain biomarker expression profiles in the detection, diagnosis, prognosis, or development of treatment regimens for various cellular hyperproliferative disorders of the bowel. For example, pre-diagnostic methods comprise detecting whether the concentration of at least BAG4 in a test biological sample from a subject is elevated as compared to a control.

Abstract: A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin having an affinity for p-N-acetylgalactosamine residues and/or a lectin having an affinity for fucose a(I, 2) galactose residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can be provided by this method.

Abstract: The present invention relates to a method for the prognosis of bone metastasis in triple negative (including basal-like) breast cancer or, alternatively, ER+ breast cancer (including luminal A and B) which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering breast cancer. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of triple negative (including basal-like) breast cancer metastasis or, alternatively, ER+ breast cancer (including luminal A and B) metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis.

Abstract: The present disclosure provides sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.

Abstract: A method for making and a resultant paper test strip product for detecting Zika antibodies indicating the presence of Zika virus in a patient sample. The paper test strip includes a strip of filter paper; and a silk fibroin solution applied to the strip of filter paper wherein the silk fibroin solution is mixed with an enzyme solution in phosphate buffered saline buffer.

Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, L4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Abstract: According to the present teachings, compositions, kits, and methods for protein melt analysis are provided that utilizing one or more fluorophore dyes. In some embodiments, a method comprises preparing a sample by mixing at least one protein with two or more dyes, and applying a controlled heating, while recording the fluorescence emission of the sample. The methods can be used, for example, for screening conditions for optimized protein stability, screening for ligands that bind and enhance protein stability (e.g., protein-protein interactions), screening for mutations for enhanced stability, screening crystallization conditions for protein stability, screening storage conditions for protein stability, and screening conditions in which a protein will be used (e.g., production conditions, treatment conditions, etc.) for protein stability.

Abstract: Devices and methods for characterization of samples are provided. Samples may comprise one or more analytes. Some methods described herein include performing enrichment steps on a device. Some methods described herein include performing mobilization of analytes. Analytes may then be further processed and characterized.

Abstract: The present invention relates in essence to an in vitro method for determining the stability, such as the shelf stability; stability over time; shelf life of a composition which comprises or essentially consists of soluble human Fc gamma receptor IIA, MB, IIIA and/or 1 MB, said method comprising the steps of contacting a surface comprising human Fc gamma receptor IIA, MB, IIIA and/or 1 MB with a set amount of aggregated human IgG; contacting said surface comprising human Fc gamma receptor IIA, MB, IIIA and/or 1 MB with a set amount of said composition of soluble human Fc gamma receptor IIA, MB, IIIA and/or 1 MB; determining the amount of aggregated human IgG which is bound to said surface comprising said human Fc gamma receptor IIA, MB, IIIA and/or 1 MB, and comparing the amount of aggregated human IgG which is bound to said surface as determined in step (c) with a reference value and (thereby) determining the stability [shelf stability; stability over time; shelf life] of said composition which comprises or

Abstract: The subject invention concerns methods and materials for diagnosing, monitoring the progress, and/or providing a prognosis for multiple myeloma and other conditions associated with antibody production in a person or animal. The methods of the invention utilize mass spectrometry for quantitative monitoring and detection of antibody produced by the plasma cells. The methods of the invention can be utilized for diagnosis, monitoring, and/or prognosis of multiple myeloma, monoclonal gammopathy, and other immunological or hematological conditions and disorders. In addition to detecting and quantifying antibody in a sample, other biological markers, such as serum albumin and/or beta-2-microglobulin, can also be detected and quantified using the present invention, and in combination with detection and quantification of antibody.

Abstract: The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A kit for detecting the presence of ET-1 or ET-1-associated biomarker in a biological sample is also disclosed.

Abstract: Methods and apparatuses for monitoring the state of health of dairy cows, in particular of entire dairy herds are provided. The method is based on analysing the haptoglobin (HP) biomarker and part of the polymeric immunoglobulin receptor (PIGR), the secretory component (SC), in a milk sample. This allows diagnosis of mastitis or systemic diseases which occur outside the udder on the basis of the protein biomarker described here. This further allows regular monitoring of the general state of health of a dairy herd. Diagnostic methods, apparatuses, and diagnostic kits for carrying out these methods are included.

Abstract: Disclosed herein are methods that aid in the determination of whether to perform imaging, such as magnetic resonance imaging (MRI) or computerized tomography (CT) scan, on a human subject that has sustained or may have sustained an injury to the head using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. These methods involve detecting levels and changes in levels of UCH-L1 in samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

Abstract: The present invention provides a method for the rapid monitoring of biological analytes in a point-of-care setting by providing a smart phone; providing a sample chamber; providing a sample; providing a dark box with a smartphone holder attached to the dark box top with the camera opening positioned about the aperture, adding a biological specimen suspected of containing a biological analyte in the sample chamber; adding a bis(2,4,6-trichlorophenyl) oxalate, an imidazole and a fluorophore to the sample chamber to react with the biological analyte; placing the sample chamber into the dark box; generating an emission from the fluorophore in response to the reaction with the biological analyte; and recording a set of time-lapse images of the emission with the smartphone.

Abstract: Devices and methods for providing and dispensing opposables onto slides are provided in which magazines loaded with opposables include retention arms to reduce movement of the opposables during shipment and processing and to reduce or eliminate contamination.

Abstract: A system that rapidly detects the presence of a target analyte in a biological test sample, which includes a sensor for measuring a detectable signal generated upon the reaction of a biosensor reagent with a specific target analyte within the sample; a reservoir card that includes the biosensor reagent that further includes living, engineered biological cells, and wherein the reservoir card is configured to interface with a test cartridge base; a test cartridge base configured to accept the reservoir card and to be placed within the testing device, wherein the test cartridge base further includes a reaction chamber adapted to receive both the biosensor reagent and the sample and a fluid displacement mechanism that includes a dispensing plunger, wherein actuation of the dispensing plunger displaces the biosensor reagent in the reservoir into the reaction chamber where the biosensor reagent is mixed with the sample; and a function verification cartridge adapted to be received and recognized by the testing devic

Abstract: Disclosed is a testing apparatus comprising a disposal container body comprising: a first opening portion that faces upward to receive a used test piece dropped by a test piece transfer part of the testing apparatus, wherein the test piece transfer part is configured to transfer the used test piece to the first opening portion; and a second opening portion that faces laterally to receive a liquid waste and to which an end of a discharge pipe of the testing apparatus is inserted, wherein the discharge pipe is configured to transfer the liquid waste to the second opening portion.

Abstract: A universal sensor mount for mounting a sensor module to a machine in a precise orientation and a corresponding sensor module installation method. The universal sensor mount includes a main body having a central main axis. A machine mounting member extends from the main body in a first direction substantially parallel to the main axis for attachment to the machine. A threaded sensor module mounting member extends from the main body in a second direction substantially parallel to the main axis for threaded attachment to the sensor module. The sensor module mounting member is rotatable relative to the main body. An adjustable locking member in the main body is operable to lock the sensor module mounting member in a selected rotational position. The selected rotational position of the sensor module mounting member determines a rotational position of the sensor module when it is attached to the sensor module mounting member.

Abstract: A hub bearing for motor vehicles includes a rotatable hub and a bearing unit. The bearing unit has a radially outer ring, provided with respective radially outer raceways, a radially inner ring, provided with respective radially inner raceways, and a plurality of rolling bodies positioned between the corresponding inner and outer raceways. The hub bearing has an optical reading device for measuring the rotational speed of one of the hub or the radially inner ring. The optical reading device is mounted on the radially outer ring.

Abstract: A vibrating beam accelerometer (VBA) with an in-plane translational proof mass that may include at least two or more resonators and be built with planar geometry, discrete lever arms, four-fold symmetry and a single primary mechanical anchor between the support base and the VBA. In some examples, the VBA of this disclosure may be built according to a micro-electromechanical systems (MEMS) fabrication process. Use of a single primary mechanical anchor may minimize bias errors that can be caused by external mechanical forces applied to the circuit board, package, and/or substrate that contains the accelerometer mechanism.

Abstract: An impact sensor has a hollow container with a spring extending therethrough. A liquid is present in the cavity. The spring biases opposing valve balls to a closed position, preventing dye that is located exterior of the cavity from entering the cavity. When a force applied to the sensor exceeds a first predetermined value, the spring is compressed or displaced, allowing at least one of the valve balls to move from the closed position to an open position, thereby allowing the dye at the moving valve ball to pass into the cavity, mixing with the liquid and providing a visual indication of the exceeded force upon the sensor.

Abstract: A physical quantity sensor includes an acceleration sensor having an acceleration sensor element and a package accommodating the acceleration sensor element, a support member having a first surface and supporting the acceleration sensor on the first surface, and an IC chip to which a second surface facing the first surface of the support member is attached, in which, in a plan view from a stacking direction of the acceleration sensor and the support member, in a case where an area of a region surrounded by an outer edge of the package is S1 and an area of the first surface is S2, S1?S2 is satisfied.

Abstract: An accelerometer sensor having electrodes forming capacitors of capacitance that vary as a function of distances between the electrodes, a control unit being arranged to perform an operation of measuring the capacitances and a control operation that comprises selectively: a fine control stage in which a first voltage is applied between one of the stationary electrodes and the movable electrode, while the other stationary electrode is at the same potential as the movable electrode; and an extended control stage in which a second voltage is applied between one of the stationary electrodes and the movable electrode, the other stationary electrode being at the same potential as the movable electrode, and the second voltage being greater in absolute value than the first voltage. A method using such a sensor.

Abstract: A device for microscopically precise positioning and guidance of a measurement or manipulation element in at least two spatial axes, comprising an outer base with side walls defining a base interior, and an xy-stage having side walls and mounting means for at least one measurement or manipulation element, the xy-stage being arranged inside of the base interior and being displaceable in an XY-plane relative to the outer base. The xy-stage is coupled to the outer base with bending elements, and with actuators designed for displacing the xy-stage relative to the outer base. The outer base is provided with at least one stiffening element rigidly connected to the side walls of the outer base, and/or that the xy-stage is provided with at least one stiffening element rigidly connected to the side walls of the xy-stage.

Abstract: Plasmonic gratings, along with methods of creating devices using width-graded plasmonic gratings are described. Plasmonic gratings may be transmission-type or closed-ended plasmonic gratings, and may be disposed on detectors to enhance the spectral range detection of the detectors or in further device architectures.

Abstract: An interconnect structure is provided which includes: a member having a first end coupled to a test card, and a second end opposite the first end; and a contact tip at the second end of the member, the contact tip to removably attach to another interconnect structure of a device under test, where a modulus of elasticity of the member varies along a length of the member.

Abstract: The inspection jig includes a rigid substrate, a flexible substrate connected to the rigid substrate, a support for supporting a part of the flexible substrate in a state that the part of the flexible substrate is protruded with respect to the rigid substrate, and a stretchable contactor provided on a protruding portion of the flexible substrate.

Abstract: The present disclosure relates to a probe head receiver, which includes: a first template, a guide plate and a spacer. The first template has a number of apertures of a first size. The guide plate has a number of apertures of a second size, each of the number of apertures of the first template is aligned with each of the number of apertures of the guide plate. The spacer is between the first template and the guide place. The second size is different from the first size.

Abstract: An electric current sensor includes a substrate, a conductive wire, a first anisotropic magnetoresistor (AMR) unit, a second AMR unit, a third AMR unit, a fourth AMR unit, a first magnetization direction setting device, and a second magnetization direction setting device. The conductive wire has a first conductive segment and a second conductive segment respectively disposed below a first end and a second end opposite to the first end of the substrate. The first AMR unit and the second AMR unit are disposed above the first end of the substrate. The third AMR unit and the fourth AMR unit are disposed above the second end of the substrate. The first magnetization direction setting device and the second magnetization direction setting device are configured to set magnetization directions of the AMR units.

Abstract: Methods, systems, and apparatus for monitoring an electrically powered element are described. A set of power usage measurements are received for a set of elements from a hardware-based power measurement device separate from the set of elements, the set of power usage measurements resulting from usage of the set of elements by a set of users. A behavior of the set of users is determined based at least in part on the set of power usage measurements. Based on the behavior of the set of users, at least one of the set of elements performs an action that affects a power function of the at least one of the set of elements.

Abstract: An apparatus includes a capacitor, a reference voltage, an input signal to be measured, and a frequency calculation circuit. The frequency calculation circuit is configured to select a capacitance value for the capacitor, charge the capacitor with the reference voltage, discharge the capacitor to a threshold voltage, and, based on a comparison of time to discharge the capacitor to the threshold voltage with a clock cycle of the input signal, determine a frequency of the input signal.

Abstract: In a method for detecting people on a floor, at least three electrodes are integrated into the floor of the room that is to be monitored. Respective measurement axes are taken into account and associated with multiple pairs of electrodes integrated into the floor. The detection method includes the following steps: for each pair of electrodes, measuring a capacitance between the two electrodes of the pair; positioning a measurement point in a coordinate system defined by N of the measurement axes at coordinates provided by the capacitances measured for the pairs of electrodes respectively associated with the N measurement axes, where N is a number greater than 1; and detecting whether a person is lying on the floor according to a detection criterion that is function of the position of the measurement point in the coordinate system.

Abstract: A device for detecting an electrical load connected to an electric power supply network. The device comprises means for injecting a test signal into the electrical network and means for identifying the presence and the nature of an electrical load connected to the electrical network on the basis of the test signal.

Abstract: The object is to provide a technique for adjusting a turn-on operation and a turn-off operation of a transistor independently from each other in simulation for evaluating characteristics of the transistor. A simulation circuit for simulation for evaluating characteristics of a transistor includes a gate power supply configured to apply a voltage to a gate terminal of the transistor, a first diode connected between the gate terminal and the gate power supply, and a second diode connected in antiparallel with the first diode.

Abstract: Systems, devices, and methods for characterizing semiconductor devices and thin film materials. The device consists of multiple probe tips that are integrated on a single substrate. The layout of the probe tips could be designed to match specific patterns on a CMOS chip or sample. The device provides for detailed studies of transport mechanisms in thin film materials and semiconductor devices.

Abstract: Example devices and methods for compensating for monitoring a surge protection device are provided. In some embodiments, a device is configured to couple to a surge protection device. The device comprises a processor that is capable of sending a DC current signal. A serial data interface is electrically connected to the processor and includes at least one shift register. The device also comprises a multiplexer coupled to the serial data interface. The serial data interface is operable to direct the DC current through the multiplexer. The device also comprises an analog to digital converter (optionally embedded within the processor) that is operable to output a digital signal corresponding to a voltage induced by the DC current signal. Returned DC signals represent surge protection device's health and a multitude of other surge module information.