Abstract: Antibody species that bind B-Cell Maturation Antigen (BCMA) are provided as well as methods of depleting BCMA-expressing cells in a patient in need thereof, comprising administering a therapeutically effective amount of the antibody species or an entity comprising a BCMA binding fragment thereof. Methods of treating B cell-related disorders associated with BCMA expression in a patient in need thereof are provided, comprising administering to the patient a therapeutically effective amount of the antibody species or an entity comprising a BCMA binding fragment thereof.

Abstract: The present invention is directed to a humanized BCMA single-chain variable fragment (scFv), comprising VH having the amino acid sequence of SEQ ID NO: 3 and VL having the amino acid sequence of SEQ ID NO: 5. The present invention is also directed to a BCMA chimeric antigen receptor fusion protein comprising from N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) of the present invention, (ii) a transmembrane domain, (iii) at least one co-stimulatory domains, and (iv) an activating domain. This humanized BCMA-CAR-T cells have specific killing activity against BCMA-positive tumor cells.

Abstract: The present invention provides a method of treating insulin-dependent diabetes mellitus in a subject, comprising administering to the subject a therapeutically effective amount of a Janus kinase inhibitor, or a pharmaceutically acceptable salt or ester thereof, or a therapeutically effective amount of intravenous immunoglobulin, or a therapeutically effective amount of a therapeutic agent that destroys B lymphocytes, or a combination thereof. The present invention also provides kits containing the same.

Abstract: Anti-CD73 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer.

Abstract: The invention relates to a method for producing a lymphocyte progenitor, the method comprising culturing a pluripotent stem cell (PSC)-derived CD34+ cell at an air-liquid interface (ALI). The invention also relates to a method for producing a B-cell progenitor, the method comprising co-culturing a PSC-derived CD34+ cell and a stromal cell in a medium comprising a CD117 activator and a NOTCH1 inhibitor. The invention further relates to a T-cell progenitor and a B-cell progenitor when produced by the methods of the invention and to use of the T-cell progenitor in the manufacture of T cell with defined antigen specificity, optionally a chimeric antigen receptor (CAR) T cell, and use of the B-cell progenitor in the manufacture of an antibody.

Abstract: Provided herein are antibodies that specifically bind human CD38, formulations and unit dosage forms comprising the antibodies, methods of preparing the antibodies and methods of using the antibodies.

Abstract: The present invention relates to novel therapeutic approaches for treating cancer in mammals, particularly in human subjects, using an inhibitor of a PLA2-GIB cofactor.

Abstract: The present disclosure provides dimeric antigen receptors (DAR) constructs comprising a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain. The two polypeptide chains that make up the dimeric antigen receptors can dimerize to form an antigen binding domain. The dimeric antigen receptors have antibody-like properties as they bind specifically to a target antigen. The dimeric antigen receptors can be used for directed cell therapy.

Abstract: The present disclosure relates to anti-CD39 antibodies, and antigen binding portions thereof and their use in treating cancer.

Abstract: There is disclosed compositions and methods relating to or derived from anti-CD38 antibodies. More specifically, there is disclosed fully human antibodies that bind CD38, CD38-antibody binding fragments and derivatives of such antibodies, and CD38-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.

Abstract: Anti-TIP-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.

Abstract: The present disclosure relates to a novel anti-HER2 antibody or an antigen-binding fragment thereof used in the prevention or treatment of cancer, a chimeric antigen receptor including the same, and uses thereof. The antibody of the present disclosure is an antibody that specifically binds to HER2 which is highly expressed in cancer cells (particularly, breast cancer or gastric cancer cells), and binds to an epitope that is different from an epitope to which trastuzumab binds.

Abstract: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.

Abstract: An object of the present invention is to provide a monoclonal antibody capable of sufficiently inhibiting a non-specific reaction caused by a non-specific factor, a non-specific reaction inhibitor containing the monoclonal antibody, and the like. The present invention relates to a monoclonal antibody against dog IgM produced by a hybridoma with accession No. NITE BP-02556.

Abstract: Disclosed is an antibody which binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

Abstract: The present invention relates to the field of antibodies useful in therapy and diagnosis. It specifically discloses bioconjugates comprising one or more antibodies bound to functionalized, magnetic nanoparticles. These bioconjugates are useful in cancer therapy, particularly for removing circulating tumor cells. The invention further pertains to specific functionalized, magnetic nanoparticles and to the manufacturing of such bioconjugates and such functionalized, magnetic nanoparticles.

Abstract: A cellulose resin in which hydrogen atoms of hydroxy groups of cellulose are substituted with a long-chain component which is a linear aliphatic acyl group having 14 or more carbon atoms and a short-chain component which is at least one of an acyl group having 2 carbon atoms and an acyl group having 3 carbon atoms, wherein a nitrogen content in the cellulose resin is 300 ppm or more and 2000 ppm or less. To provide a cellulose resin excellent in mechanical properties and heat decomposition resistance.

Abstract: A wheat straw pulp, a preparation method therefor, an application thereof, and a method for adjusting the degree of substitution of CMC. The preparation method for the wheat straw pulp comprises the following steps: using water as a medium, performing ultrasonic crushing on wheat straw, performing solid-liquid separation, and collecting the solid to obtain wheat straw pulp, the temperature of the ultrasonic crushing being 25-100° C. In the preparation method, by using water as a medium, wheat straw is dissociated into wheat straw fibers in water in a mild temperature condition by means of ultrasonic crushing accompanied by H2O2. The wheat straw pulp can be used for preparing CMC. By adjusting different technological conditions to adjust the properties of the wheat straw pulp, CMC having different degrees of substitution can be prepared.

Abstract: The present invention relates to a petroleum resin having the content of a volatile organic compound component of less than 100 wt ppm; and a hydrogenated petroleum resin having the content of a volatile organic compound component of less than 100 wt ppm.

Abstract: A conjugated diene-based polymer catalyzed with a lanthanide rare earth element, and having high linearity and improved compounding properties, and a method for preparing the same are provided. The conjugated diene-based polymer catalyzed with a lanthanide rare earth element has high linearity, and if applied to a rubber composition, may show excellent processability, tensile strength and viscoelasticity.

Abstract: The present invention relates to a method of preparing a conjugated diene-based polymer by continuous polymerization using two or more reactors, and relates to a method of preparing a conjugated diene-based polymer which is capable of providing a conjugated diene-based polymer having improved Mooney viscosity and excellent cis 1,4 bond content and linearity, by controlling the injection amount of a conjugated diene-based monomer to each reactor in a specific ratio and resolving the deterioration phenomenon of physical properties, which might be generated in continuous reaction.

Abstract: An ethylene/1-hexene copolymer has a density from 0.9541 to 0.9600 gram per cubic centimeter (g/cm3), a molecular mass dispersity (ÐM=Mw/Mn) from greater than 2.0 to 3.5; and a Z-average molecular weight (Mz) from 120,000 to 240,000 grams per mole (g/mol). Methods of making and using same. Articles containing same.

Abstract: A gel composition is herein disclosed. According to one embodiment, the composition comprises a (i) a styrenic block copolymer, (ii) an oil; and (iii) optional additives; wherein the styrenic block copolymer has a structure ABi or iAB, wherein A is a monoalkenyl arene block, B is a conjugated diene block, and i is an isoprene attachment. The isoprene attachment i is substantially unsaturated and the conjugated diene block B is substantially saturated. The gel composition before curing exhibits thixotropic behavior, with a viscosity ranging from about 5000 mPa.s to about 30000 mPa.s. at 25° C. and a shear rate of 20 s?1.

Abstract: The present invention is a modified resin for a molded article obtained by modifying an ethylene/unsaturated carboxylic acid copolymer with guanidine carbonate, wherein a melt flow rate of the ethylene/unsaturated carboxylic acid copolymer is 20 (g/10 minutes) or more and 600 (g/10 minutes) or less.

Abstract: This invention relates to a substrate for mammalian cell culture comprising a co-polymer hydrogel comprising monomeric units of acrylamide, bisacrylamide and a coupling compound, such as 6-acylamidohexanoic acid (6AHA). A cell adhesion molecule, such as a component of the extracellular matrix (ECM), is covalently coupled to the coupling compound monomeric units of the co-polymer. The stiffness and cell adhesion molecule density of the substrate can be independently controlled by altering the concentration of acrylamide and coupling compound in the hydrogel, respectively. Substrates and methods and kits for their production are provided, along with cell culture systems and methods of culturing mammalian cells.

Abstract: Modeling material formulation systems usable in additive manufacturing, 3D inkjet printing in particular, of three-dimensional objects, are provided. The formulations comprise two or more curable materials, such that an average molecular weight of the curable materials in each formulation is no more than 500 grams/mol, such that each formulation features a viscosity of no more than 50 centipoises at a temperature of 35° C. Kits comprising the formulations or formulation systems and additive manufacturing processes utilizing same are also provided.

Abstract: A comb copolymer A2 including at least two boronic ester functions, the copolymer including a main chain and side chains, and at least one portion of the side chains of the copolymer A2 made of oligomers. Also, a composition resulting from mixing at least one polydiol compound A1 and a copolymer A2. The compositions exhibit very varied rheological properties depending on the proportion of the compounds A1 and A2 used. Also, a lubricant composition including such a mixture and at least one lubricating oil. Also, use of this composition to lubricate a mechanical part.

Abstract: The present invention provides vinyl-based resin particles capable of forming uniform pores in a thermosetting resin film when the particles are used as a pore-forming material for a thermosetting resin. Specifically, the present invention provides vinyl-based resin particles for use in making a thermosetting resin porous, the particles having a temperature of 300 to 350° C. at 10% mass loss when heated at a rate of 10° C./min in an air atmosphere, and the particles having a mass loss percentage of 85 to 100% after being heated at 350° C. for 5 hours in an air atmosphere.

Abstract: The invention generally relates to linear-bottlebrush-linear copolymer blocks and methods of making and using same. The disclosed copolymer blocks can be useful in, for example, the formation of polymer networks that replicate biological stress-strain behavior. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Compositions resulting from the mixing of at least: a comb polydiol copolymer A1 and a compound A2 including at least two boronic ester functional groups, the comb polydiol copolymer A1 including a main chain and side chains, at least a portion of the side chains of the copolymer A1 being composed of oligomers. They exhibit very varied rheological properties depending on the proportion of the compounds A1 and A2 used. Composition resulting from the mixing of at least one lubricating oil with such a composition of associative and exchangeable polymers and use of this composition for lubricating a mechanical part.

Abstract: The present invention relates to a catalyst system which improves the work life of acid-catalyzed resole resins at higher ambient temperatures and provides extended shelf life. The catalyst system comprises an inorganic acid catalyst and one or more polyhydric alcohols. In particular, the present invention relates to a catalyst system wherein the inorganic acid and the alcohol do not convert to an ester when added to the resole resin.

Abstract: A method for producing a polyurethane foam includes mixing and reacting a polyurethane foam raw material containing a polyol, an isocyanate, a foaming agent, and a catalyst, wherein the polyurethane foam raw material contains sodium bicarbonate and an organic solid acid such as citric acid or malic acid.

Abstract: The present disclosure relates to processes for the production of a polyurethane material, where (a) di- and/or polyisocyanates, (b) compounds which have hydrogen atoms reactive toward isocyanate groups and which do not include compounds having carbon-carbon double bonds, (c) compounds including at least one carbon-carbon double bond, (d) optionally catalyst that accelerates the urethane reaction, and (e) optionally other auxiliaries and additives are mixed to give a reaction mixture and the mixture is hardened at temperatures above 120° C. The present disclosure further relates to a polyurethane material obtainable by this process, and also to the use of the polyurethane material, in particular of a polyurethane fiber-composite material as structural components.

Abstract: A difunctional biphenyl compounds corresponding to formula (I) wherein Alk, Alk? and R are as defined in the description. These compounds are suitable as hardeners for thermosetting resins, especially epoxy resins.

Abstract: The present invention relates to a hydrophilizing agent for producing a self-emulsifying polyisocyanate composition, the hydrophilizing agent comprising an anionic compound represented by the following formula (1): wherein X represents a sulfo group or a hydroxysulfonyloxy group, R1 represents a straight-chain or branched alkylene group, and R2 represents a straight-chain or branched alkyl group; the total number of carbon atoms included in R1 and R2 is 6 or more and less than 14, and one or two or more carbon atoms in the groups R1 and R2 are optionally replaced with an oxygen atom(s).

Abstract: An electrical device includes at least one cross-linked layer obtained from a polymer composition that has: at least one polymer comprising one or more epoxy function(s), and at least one cross-linking agent. The cross-linking agent is selected from: a non-aromatic cyclic amine, an imidazole of formula (I) where R1 and R2 independently represent a hydrogen atom or a hydrocarbon group, R3 and R4 independently represent a hydrogen atom or a hydrocarbon group, or R3 and R4 form, together with the carbon atoms of the imidazole ring to which they are attached, a ring, with the imidazole being associated with a cross-linking co-agent having at least one reactive function capable of reacting with the epoxy function of said polymer, and, a mixture thereof.

Abstract: Disclosed is a hydrogenated norbornene ring-opened polymer, wherein a proportion of a norbornene-derived repeating unit is 90% by mass or more, a meso diad fraction of the norbornene-derived repeating unit is 80% or more, and in an X-ray diffraction pattern measured at 25° C. using a CuK? radiation source, an X-ray diffraction peak is observed which has a peak top positioned in a diffraction angle (2?) range of 17° or more and 18° or less.

Abstract: A method of carrying out a metathesis reaction includes the combination of at least one alkene or non conjugated diene with a Ruthenium-based catalyst with an cyclic(alkyl)(amino)carbene ligand to form a reaction mixture and heating the reaction mixture to a temperature of 100° C. or greater. The reaction can be an ADMET, ROMP, a metathesis ring-closure or an olefin exchange reaction.

Abstract: Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed. Examples demonstrate critical molecular weights in combination with exposed carboxylic and/or hydroxyl groups, and methods of making Typically, the compositions are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the compositions are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.

Abstract: Provided is a method that can stably produce polyaryletherketone that has a high degree of polymerization and can be easily recovered. The method for producing polyaryletherketone includes: a polycondensation step of carrying out desalting polycondensation in a reaction solvent; and a cooling step of cooling a reaction mixture after desalting polycondensation is completed. When the method is implemented, the polycondensation step is carried out in a hydrophilic solvent under pressurized conditions, and the polymerization temperature in the polycondensation step is at or above the boiling point of the hydrophilic solvent at ambient pressure. In addition, the polymer content in terms of monomers at the time of cooling in the cooling step is from 1 part by mass to 50 parts by mass, per 100 parts by mass of the hydrophilic solvent in the reaction mixture.

Abstract: A process for synthesizing polyamide PA 6-6, including a first step of reacting, in the presence of water, a compound of R0COO—(CH2)4—COOR?0 in which R0 and R?0, which may be identical or different, represent H or a linear or branched alkyl radical comprising from 1 to 4 carbon atoms, with hexamethylenediamine (HMDA), at a temperature of less than or equal to 160° C., to form a reaction medium, and then a second step of heating the reaction medium to a temperature of greater than or equal to 200° C.; the reaction medium also including a compound of R1—COO—(CH2)n—CH?CH—(CH2)n—COO—R2 and/or a compound of R3—(CH2)m—CH?CH—(CH2)n—COO—R4.

Abstract: The present invention provides a method of manufacturing a polyimide film including unit polymers that are omnidirectionally distributed, and a polyimide film. The present invention also provides a graphite sheet having good quality manufactured using the polyimide film.

Abstract: The present invention relates to hydrogels and polymers suitable as building blocks for hydrogels as well as advantageous methods for encapsulating cells and/or particles. Also provided are kits and methods for producing the hydrogels.

Abstract: Described is a silicone hydrogel contact lens having non-uniform morphology. The contact lens may be made from a reactive mixture comprising: a silicone-containing component; a hydrophilic component; a non-reactive polymeric internal wetting agent; and a polymerization initiator, the contact lens having an oxygen permeability of at least about 60 barrers, and wherein the molar ratio in the lens of the polymeric non-reactive internal wetting agent to silicone, without a surface treatment, is greater in the lens's surface than in its bulk.

Abstract: Methods for synthesizing a hydrogel are disclosed. The method includes the steps of: (a) dissolving effective amounts of a monomer, a crosslinker, and a photoinitiator in deionized water, wherein the overall concentration is about 200 mg/ml; (b) preparing a solution of a fluorinated acrylate or diacrylate in ethanol wherein the overall concentration is about 200 mg/ml; (c) separately stirring the solutions prepared in steps (a) and (b) for approximately three hours; (c) gradually introducing the solution from step (b) into the solution from step (a); (d) stirring the resulting solution from step (c) for about two hours; and (e) exposing the solution from step (d) to UV-A irradiation for about 15 minutes.

Abstract: The present invention relates to a covalently cross-linked hyaluronic acid aerogel, a hydrogel, and a preparation method thereof. The method includes steps of: taking hyaluronic acid as a raw material to prepare a hyaluronic acid aqueous solution; taking 1,4-butanediol diglycidyl ether, ethylene glycol diglycidyl ether, or polyethylene glycol diglycidyl ether as a crosslinking agent; promoting a chemical crosslinking through covalent bonds between the crosslinking agent and the hyaluronic acid by a freeze-drying technique to obtain a covalently cross-linked hyaluronic acid aerogel; furthermore, soaking the covalently cross-linked hyaluronic acid aerogel in purified water, which absorbing water and swelling to obtain a covalently cross-linked hyaluronic acid hydrogel. The covalently cross-linked hyaluronic acid aerogel has good liquid absorption properties, and can quickly absorb water and swell to the covalently cross-linked hyaluronic acid hydrogel.

Abstract: Provided is a highly stable non-aqueous dispersion even without surfactants. The present invention relates to a non-aqueous dispersion including a fluoropolymer and a non-aqueous solvent, the fluoropolymer in the non-aqueous dispersion having an average dispersed particle size of smaller than 1.0 ?m, the fluoropolymer being present in an amount of 5 to 45% by mass, the non-aqueous solvent having a surface tension of 30 mN/m or lower, the non-aqueous dispersion containing a surfactant in an amount of less than 0.1% by mass relative to the fluoropolymer.

Abstract: Provided are pre-dynamically cross-linked compositions including a networking impact modifier additive. Compositions include a pre-dynamic cross-linked polymer composition including polyester chains joined by a coupler component and one or more networking impact modifier additives. Methods of making the compositions are also described.

Abstract: A method for producing a flexible-packaging film in which a first substrate and a second substrate are laminated with a reactive adhesive of a polyisocyanate composition (X) and a polyol composition (Y) therebetween includes a two-component separate application step in which a liquid mixture applied to the first substrate and including the polyisocyanate composition (X) and the polyol composition (Y), and a catalyst (Z) formed in a dot pattern on the second substrate are brought into contact with each other to achieve contact-bonding together. The substrates are preferably plastic films, metal vapor-deposition films, or metal foils. As the second substrate, a non-oriented film is preferably employed.

Abstract: The present invention provides a graphite sheet polyimide film derived from a first precursor composition comprising a first polyamic acid, the polyimide film comprising a sublimable inorganic filler and a graphene-containing spherical polyimide-based filler.