Patents Issued in December 24, 2020
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Publication number: 20200399536Abstract: A quantum dot, and a composite and a display device including the quantum dot. The quantum dot comprises a semiconductor nanocrystal core comprising indium and phosphorous, a semiconductor nanocrystal shell disposed on the semiconductor nanocrystal core, the first semiconductor nanocrystal shell comprising zinc, selenium, and sulfur, wherein the quantum dot does not comprise cadmium wherein the quantum dot has a maximum photoluminescence peak in a green light wavelength region, and wherein in an ultraviolet-visible (UV-Vis) absorption spectrum of the quantum dot, a ratio A450/Afirst, of an absorption value at 450 nm to an absorption value at a first excitation peak is greater than or equal to about 0,7, and a valley depth (VD) defined by the following equation is greater than or equal to about 0.Type: ApplicationFiled: June 18, 2020Publication date: December 24, 2020Inventors: Tae Gon KIM, Shin Ae JUN, Taek hoon KIM, Hyeyeon YANG, Nayoun WON, Jongmin Lee, Mi Hye LIM
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Publication number: 20200399537Abstract: Liquid crystal molecules are described with desirably reduced attenuation in portions of the long-wave infrared (LWIR) spectrum. The molecules include a linear hydrocarbon of varying length (CnH2n+1, where n, for example, is from 4-7), a deuterated phenyl core comprising 2 or 3 rings, and one terminal cyano group. These enable electro-optic such as light modulators, phased arrays, polarization gratings, refractive steerers, and the like, operable at LWIR.Type: ApplicationFiled: October 30, 2019Publication date: December 24, 2020Inventors: Jawad Naciri, Christopher M. Spillmann, Jakub Kolacz, Henry G. Gotjen, Jason D. Myers, Jesse A. Frantz, Robel Y. Bekele
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Publication number: 20200399538Abstract: An object of the present invention is to provide an optical film which is excellent in the adhesiveness between a polymer support and a photo alignment film and in which a liquid crystal compound having reverse wavelength dispersibility is uniformly aligned. Another object of the present invention is to provide a polarizing plate formed of the optical film, and an image display device formed of the optical film or the polarizing plate.Type: ApplicationFiled: September 8, 2020Publication date: December 24, 2020Applicant: FUJIFILM CorporationInventors: Nobuyuki AKUTAGAWA, Kunihiro KASEZAWA, Takashi KOMIYAMA
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Publication number: 20200399539Abstract: The present invention provides a compound represented by the general formula (i), which has a partial structure Ki1 represented by one of the general formulae (K-1) to (K-6) and has a ring B with at least one P-Sp- group and with at least one Ri2 (Ri2 denotes a linear or branched alkyl group having 2 to 10 carbon atoms or a linear or branched halogenated alkyl group having 2 to 10 carbon atoms, —CH2— in the alkyl or halogenated alkyl group is optionally substituted with —CH?CH—, —O—, —COO—, or —OCO—, but —O— is not adjacent to another —O—). Thus, the compound in a liquid crystal composition adsorbs to substrates between which the liquid crystal composition (a liquid crystal layer) exists. The compound can hold vertically aligned liquid crystal molecules, can improve alignment stability, and can ensure low-temperature storage stability.Type: ApplicationFiled: February 14, 2019Publication date: December 24, 2020Applicant: DIC CorporationInventors: Masanao Hayashi, Ayaki Hosono, Shota Kosaka
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Publication number: 20200399540Abstract: A flame-retardant compound, a process for forming a flame-retardant compound, and an article of manufacture. The flame-retardant compound includes a tetrazine moiety and at least one ligand comprising a brominated moiety. The process includes providing starting materials, which include a nitrile compound, a bromine source, and hydrazine. The process also includes reacting the starting materials to form a tetrazine flame retardant. The article of manufacture includes a polymer and a flame-retardant compound having a tetrazine moiety and at least one ligand comprising a brominated moiety.Type: ApplicationFiled: June 19, 2019Publication date: December 24, 2020Inventors: Brandon M. Kobilka, Jason T. Wertz, Scott B. King, Jacob Porter
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Publication number: 20200399541Abstract: The present invention provides methods for decomposing and extracting compositions for the recovery of petroleum-based materials from composites comprising those petroleum-based materials, comprising subjecting the compositions and/or composites to microwave radiation, wherein the microwave radiation is in the range of from about 4 GHz to about 18 GHz. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.Type: ApplicationFiled: July 21, 2020Publication date: December 24, 2020Inventors: Frank G. Pringle, Carl Everleigh, Julian Forthe
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Publication number: 20200399542Abstract: A process for converting a mixture of hydrogen and carbon monoxide gases to a composition comprising alcohols and liquid hydrocarbons by means of a Fischer-Tropsch synthesis reaction, said process comprising contacting a mixture of hydrogen and carbon monoxide gases, preferably in the form of synthesis gas mixture, with a supported Co—Mn Fischer-Tropsch synthesis catalyst, wherein: the support material of the supported Co—Mn Fischer-Tropsch synthesis catalyst comprises a material selected from titania, zinc oxide, zirconia, and ceria; the supported synthesis catalyst comprises at least 2.5 wt % of manganese, on an elemental basis, based on the total weight of the supported synthesis catalyst; the weight ratio of manganese to cobalt, on an elemental basis, is 0.2 or greater; the molar ratio of hydrogen to carbon monoxide is at least 1; and, the Fischer-Tropsch synthesis reaction is conducted at a pressure in the range of from 1.0 to 10.0 MPa absolute.Type: ApplicationFiled: February 6, 2019Publication date: December 24, 2020Inventor: Alexander James PATERSON
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Publication number: 20200399543Abstract: Methanol-to-gasoline (MTG) conversion may be performed with a methanol recycling. Methanol may be fed to a first reactor where it may be catalytically converted under dimethyl ether formation conditions in the presence of a first catalyst to form a product mixture comprising dimethyl ether (DME), methanol, and water. The DME may be separated from the methanol and the water and delivered to a second reactor. In the second reactor, the DME may be catalytically converted under MTG conversion conditions in the presence of a second catalyst to form a second product mixture comprising gasoline hydrocarbons and light hydrocarbon gas. The methanol and the water from the first reactor may be separated further to obtain substantially water-free methanol, which may be returned to the first reactor. The separation of methanol from the water may be performed using the light hydrocarbon gas to effect stripping of the methanol.Type: ApplicationFiled: June 16, 2020Publication date: December 24, 2020Inventors: Mohsen N. Harandi, Suriyanarayanan Rajagopalan, David W. Staubs, Terry E. Helton, Mitch L. Hindman
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Publication number: 20200399544Abstract: Methanol-to-gasoline (MTG) conversion may be performed with forward methanol processing. Methanol may be fed to a first reactor where it may be catalytically converted under dimethyl ether formation conditions in the presence of a first catalyst to form a product mixture comprising dimethyl ether (DME), methanol, and water. The DME may be separated from the methanol and the water and delivered to a second reactor. In the second reactor, the DME may be catalytically converted under MTG conversion conditions in the presence of a second catalyst to form a second product mixture comprising gasoline hydrocarbons and light hydrocarbon gas. The methanol and the water from the first reactor may be separated further to obtain substantially water-free methanol, which may be delivered to the second reactor. The separation of methanol from the water may be performed using the light hydrocarbon gas to effect stripping of the methanol.Type: ApplicationFiled: June 16, 2020Publication date: December 24, 2020Inventors: Mohsen N. Harandi, Suriyanarayanan Rajagopalan, David W. Staubs, Terry E. Helton, Mitch L. Hindman
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Publication number: 20200399545Abstract: Disclosed is a method and a device for purification and desulfurization of liquid hydrocarbons, which, compared to sodium dispersion desulfurizing processes like already been disclosed, open up additional fields of application and greatly improves economy and achievable results.Type: ApplicationFiled: May 30, 2018Publication date: December 24, 2020Inventor: Thomas Andreas Guenther
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Publication number: 20200399546Abstract: Methods and systems for producing olefins from a naphtha feedstock are provided. Methods can include pyrolyzing the naphtha feedstock in the presence of hydrogen gas to produce a first effluent, separating the first effluent into light components, heavy components and one or more olefin product streams, steam cracking the light components to produce a second effluent, and extracting aromatics, if any, from the heavy components to produce a third effluent.Type: ApplicationFiled: November 15, 2018Publication date: December 24, 2020Inventor: Joris VAN WILLIGENBURG
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Publication number: 20200399547Abstract: A desolidification process enables the isolation and extraction of solid additives from an unreacted petroleum residue stream. In a hydrocracking process that mixes a solid additive with a petroleum residue feedstock to convert the petroleum residue to higher-value distillates, the desolidification process enables the recovery of the unreacted petroleum residue for conversion to a saleable product. The desolidification process involves the mixture of one or more solvents with a slurry in which solids are integrated in the petroleum residue to generate a mixture having a decreased density and viscosity as compared to the slurry, which facilitates removal of the solids.Type: ApplicationFiled: June 23, 2020Publication date: December 24, 2020Applicant: KELLOGG BROWN & ROOT LLCInventors: Cassandra Schoessow, Douglas Piotter, Anand Subramanian
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Publication number: 20200399548Abstract: A gas purification device removes a part of ammonia contained in a first gas; recovers a first off-gas containing the removed ammonia, removes hydrogen sulfide and ammonia from a second gas produced by removing the part of ammonia, recovers a second off-gas containing the removed hydrogen sulfide and ammonia, and combusts the first off-gas and the second off-gas. The gas purification device includes: a first combustion chamber in which combustion is performed in a reducing atmosphere; a second combustion chamber in which combustion is performed in a reducing atmosphere downstream of the first combustion chamber; and a third combustion chamber in which combustion is performed in an oxidizing atmosphere downstream of the second combustion chamber. The first off-gas flows into the first combustion chamber and the second off-gas flows into the third combustion chamber.Type: ApplicationFiled: March 5, 2019Publication date: December 24, 2020Applicant: Mitsubishi Heavy Industries Engineering, Ltd.Inventors: Kaori Yoshida, Ayumu Yamazaki, Rikio Kan, Seiji Kakesako
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Publication number: 20200399549Abstract: A biofuel composition and a process for the manufacture of a biofuel composition including lignin and ethanol as the main combustible components of the biofuel composition and having total ash below 1% w/w based on total mass of dry matter in the biofuel composition.Type: ApplicationFiled: February 18, 2019Publication date: December 24, 2020Applicants: A.P. MØLLER - MÆRSK A/S, KØBENHAVNS UNIVERSITETInventors: Claus FELBY, Stefan MAYER, Yohanna Cabrera OROZCO
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Publication number: 20200399550Abstract: An improved fuel, particularly an improved transport fuel composition is provided. Alternate fuels to traditional oil derived petrol and diesel have been considered particularly for transport purposes. However, there are limitations that have prevented their widespread use. A fuel composition is provided for use in an internal combustion engine comprising an organic carrier fuel having a particulate additive dispersed therein, the particulate additive being a lubricant.Type: ApplicationFiled: December 24, 2018Publication date: December 24, 2020Inventors: Dongke Zhang, Michael Martella, Matthew Martella, Mingming Zhu, Zhezi Zhang
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Publication number: 20200399551Abstract: The present application provides charcoal briquettes infused with a flammable composition including fusel oil and/or one or more dehydration products of fusel oil and the flammable compositions including one or more dehydration products of fusel oil.Type: ApplicationFiled: September 4, 2020Publication date: December 24, 2020Inventors: Ryan B. Adolphson, Daniel P. Geller, Levi T. Mills, Marcus Leonard Smith, Fredrick W. Huszagh, II
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Publication number: 20200399552Abstract: Compositions include ether ester compounds derived from neo-acids, lubricating oil base stocks containing such ester compounds, and lubricating oil compositions containing such ester compounds. Methods can include making and formulating compositions containing ether ester compounds derived from neo-acids.Type: ApplicationFiled: May 12, 2020Publication date: December 24, 2020Inventors: Abhimanyu O. Patil, Satish Bodige, Kyle G. Lewis
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Publication number: 20200399553Abstract: Compositions include ether ester compounds derived from neo-alcohols, lubricating oil base stocks containing such ester compounds, and lubricating oil compositions containing such ester compounds. Methods can include making and formulating compositions containing ether ester compounds derived from neo-alcohols.Type: ApplicationFiled: May 12, 2020Publication date: December 24, 2020Inventors: Abhimanyu O. Patil, Satish Bodige, Kyle G. Lewis
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Publication number: 20200399554Abstract: The present disclosure relates to a high performance calcium sulfonate greases with enhanced performance benefits and methods for making the same.Type: ApplicationFiled: September 2, 2020Publication date: December 24, 2020Inventors: Anand KARVE, Vishal NANDURKAR
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Publication number: 20200399555Abstract: The invention is directed to a method for reducing low speed pre-ignition events in a spark-ignited direct injection internal combustion engine by supplying to the sump a lubricant composition which contains an oil of lubricating viscosity and an ashless dispersant. The ashless dispersant may be selected from succinimide compounds prepared from aliphatic or aromatic amines.Type: ApplicationFiled: September 3, 2020Publication date: December 24, 2020Inventors: Patrick E. Mosier, Jeffry G. Dietz, Alexander Sammut, Mary Galic Raguz, Matthew D. Gieselman
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Publication number: 20200399556Abstract: The invention is directed to a method for reducing low speed pre-ignition events in a spark-ignited direct injection internal combustion engine by supplying to the sump a lubricant composition which contains an oil of lubricating viscosity and an ashless dispersant. The ashless dispersant may be selected from succinimide compounds prepared from aliphatic or aromatic amines.Type: ApplicationFiled: September 3, 2020Publication date: December 24, 2020Inventors: Patrick E. Mosier, Jeffry G. Dietz, Alexander Sammut, Mary Galic Raguz, Matthew D. Gieselman
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Publication number: 20200399557Abstract: A process for the production of a refined oil having a reduced content of glycidyl esters and hydroperoxides characterized in that it comprises subjecting an edible oil to the following steps, a bleaching step, a deodorization step, re-bleaching step on the deodorized oil, and a further refining step, wherein the further refining step is carried out by passing the bleached edible oil obtained in step c) through an oil refining equipment consisting of a stripping column with packing and not more than one oil collection tray.Type: ApplicationFiled: February 21, 2019Publication date: December 24, 2020Applicant: Cargill, IncorporatedInventors: Michael MAIWORM, Armin Willem-Friedrich Hermann TARNOW
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Publication number: 20200399558Abstract: Provided herein are screening methods for identifying one or more compounds that impart a smell, taste and/or trigeminal sensation, for example, odorants contributing to an olfactory quality. Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds.Type: ApplicationFiled: June 17, 2020Publication date: December 24, 2020Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Anandasankar RAY, Joel KOWALEWSKI
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Publication number: 20200399559Abstract: Compositions are provided that include a matrix and a polymeric composite particles disposed in the matrix. The polymeric composite particles include a porous polymeric core and a fragrance positioned within the porous polymeric core. Polymeric composite particles are also provided including a porous polymeric core, a fragrance positioned within the porous polymeric core, and a coating layer around the porous polymeric core. Further, a method of determining a minimum temperature of a composition is provided including providing a composition including polymeric composite particles disposed in a matrix, heating the composition, releasing at least a portion of the fragrance as a vapor from the porous polymeric core of the polymeric composite particles at or above the minimum temperature, and detecting at least a portion of the fragrance vapor in a location outside of the matrix.Type: ApplicationFiled: September 9, 2020Publication date: December 24, 2020Inventors: Michael W. Kobe, Mary M. Caruso Dailey, Luke E. Heinzen, Hassan Sahouani
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Publication number: 20200399560Abstract: The present invention relates to new odorous acetals which are useful as fragrance or flavor materials in particular in providing vanilla and spicy notes with a natural impression resembling vanilla absolute.Type: ApplicationFiled: December 6, 2018Publication date: December 24, 2020Inventors: Leszek DOSZCZAK, Andre SCHOLTEN, Wojciech I DZIK
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Publication number: 20200399561Abstract: Surfactant-containing compositions are described which include a protein component that has the effect of improving the surface-active properties of the surfactants contained in the compositions. The surfactant-containing compositions having the protein component demonstrate significantly lower critical micelle concentrations (CMC), reduced surface tensions, and reduced interfacial tensions than do comparable compositions having no protein component. In addition, the surfactant-containing compositions having the protein component has the effect of converting greasy waste contaminants to surface active materials.Type: ApplicationFiled: September 2, 2020Publication date: December 24, 2020Applicant: ADVANCED BIOCATALYTICS CORPORATIONInventors: John W. Baldridge, Carl W. Podella
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Publication number: 20200399562Abstract: A method of treating a fabric, comprising contacting the fabric with an aqueous liquor comprising a fabric care component selected from the group consisting of cationic softening-compounds, silicone softening-compounds, paraffins, dispersible polyolefins, waxes and mixtures thereof; and contacting the fabric with an aqueous liquor comprising a nuclease enzyme, preferably a deoxyribonuclease or ribonuclease enzyme. The aqueous liquor may be provided by adding a cleaning or treatment composition to water. Preferably the composition comprises a surfactant, the wash liquor comprising from 0.05 to 4 g/l of a surfactant.Type: ApplicationFiled: August 28, 2020Publication date: December 24, 2020Inventors: Neil Joseph Lant, Rebecca Louise Wood, Jeremie Robert Marcel Gummel
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Publication number: 20200399563Abstract: The invention relates to solidification of liquid nonionic surfactants with a binder, carrier, or both binder and carrier to form a solidified surfactant composition. In particular, the invention relates to solidification of liquid nonionic surfactants utilizing drying device(s), wherein the feed composition contains at least one liquid nonionic surfactant and the binder, carrier, or binder and carrier to form a solidified surfactant composition. The solidified surfactant compositions can be useful in various cleaning compositions.Type: ApplicationFiled: June 22, 2020Publication date: December 24, 2020Inventors: Wendy Lo, Minlong He, Katherine J. Molinaro, Erik C. Olson, Mark Peterson, Kevin D. Lewis, JR.
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Publication number: 20200399564Abstract: Catechol-group-containing polymers with amine or amide functionality, containing at least one repeating unit of the formula (I) and at least one repeating unit of the formula (II) and optionally further repeating units The repeating units of the formula (II) are different from the repeating units of the formula (I) and the molar ratio of the units of the formula (I) to the units of the formula (II) is in the range from 0.5-to-1 to 4-to-1, are suitable for the dirt-repellent finishing of substrate surfaces, particularly surfaces of textiles, glass, ceramics or plastics. The polymers have an excellent adhesion to these surfaces, so that during cleaning of a substrate surface they adsorb to the substrate surface from the aqueous cleaning or washing liquor and realize their effect.Type: ApplicationFiled: June 18, 2020Publication date: December 24, 2020Inventors: Nils Wedler, Christian Kropf, Laura Hartmann, Stefan Schmidt, Lukas Fischer, Alexander Strzelczyk
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Publication number: 20200399565Abstract: Provided therefore herein is a novel acidic fluoride activated cleaning chemistry. The present invention includes novel acidic fluoride activated, unique organic-solvent based microelectronic selective etchant/cleaner compositions with high metal nitride etch and broad excellent compatibility, including tungsten (W) and low-k. It does not use W-incompatible oxidizers, such as hydrogen peroxide or particle-generating corrosion inhibitors.Type: ApplicationFiled: March 23, 2017Publication date: December 24, 2020Inventors: Chien-Pin Sherman Hsu, Sam Chun-Yi Chiu, Chu-Hung Wade Wei, Mi Yeon Oh
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Publication number: 20200399566Abstract: Natural liquid potassium soap compositions and methods of manufacturing and using the same are provided with thickening by the addition of chloride salts, such as sodium chloride and potassium chloride. The natural liquid potassium soap compositions may contain one or more fatty acids with carbon length ranging from four (C4) to twenty-two (C22) or natural fatty acid mixtures with coconut oil, olive oil, tallow, sunflower oil, safflower oil, and/or tall oil fatty acids which are saponified with lye. The saponification lye is preferably potassium hydroxide. Preferred embodiments contain potassium salts of fatty acids comprising at least oleic acid (C18:1 cis-9), olive oils, coconut oils or mixtures thereof. The chloride salt is added in either solid or liquid form following saponification and neutralization.Type: ApplicationFiled: September 4, 2020Publication date: December 24, 2020Applicant: Vanguard Soap LLCInventor: Scott A. Smith
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Publication number: 20200399567Abstract: Caustic-free detergent compositions are provided. Detergent compositions including an aminocarboxylate, water conditioning agent, non-caustic source of alkalinity and water beneficially do not require the use of additional surfactants and/or polymers to provide suitable detergency and prevent scale build-up on treated surfaces and enhance protein removal from the treated surfaces. Beneficially the detergent compositions have a concentrate pH less than about 11.5. The detergent compositions are used with a sanitizer to employ the low alkaline detergent compositions are particularly suitable for use as low temperature ware wash detergents that beneficially reduce scale build-up. Methods of employing the low alkaline detergent compositions are also provided.Type: ApplicationFiled: September 2, 2020Publication date: December 24, 2020Inventors: Erin Jane Dahlquist Howlett, STEVEN E. LENTSCH, Terrence P. Everson, Carter M. Silvernail
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Publication number: 20200399568Abstract: The present disclosure relates to a washing- and cleaning-active polymer film which includes a mixture of at least one polymer P1) including polymerized units of at least one ?,?-ethylenically unsaturated carboxylic acid or a salt thereof. The washing- and cleaning-active polymer film optionally further includes comonomers and a polyoxyalkylene ether PE). The disclosure furthermore relates to a process for producing such a washing- and cleaning-active polymer film and to a covering or coating for a detergent or cleaner portion which includes such a polymer film.Type: ApplicationFiled: September 5, 2018Publication date: December 24, 2020Inventors: Juergen DETERING, Maria DE MORAGAS, Yannick FUCHS, Claudia ESPER, Benjamin SCHMIDT-HANSBERG, Markus MEISE, Dominik LANZINGER, Aaron WAGNER, Helmut WITTELER, Matthias ARNDT
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Publication number: 20200399569Abstract: A device including a lid body including a connection end, a top end having an opening therein, a pouring spout body encompassing the opening, and, a stem body including an internal housing configured to hold an ion exchange resin-filed cartridge therein, a cap region, collar, a beverage conduit, and a stem body air tube. The cap region configured to couple to the connection end of the lid body to thereby form a first liquid-tight seal coupling between the connection end of the lid body and a top end of the ion exchange resin-filed cartridge, and, form a second a liquid-tight seal coupling between a base region of the internal housing and a bottom end of the ion exchange resin-filed cartridge. First and second collar wall portions sized to fit inside a mouth of a beverage container and to be located outside of the mouth. The beverage conduit spans the collar with a first and second openings to the base region and an interior of the beverage container.Type: ApplicationFiled: August 31, 2020Publication date: December 24, 2020Inventors: David L. Meadows, Derek B. Meadows
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Publication number: 20200399570Abstract: Methods of separating components traditionally considered as waste material from mold-fermented compositions are described. The waste components can be separated either from unfiltered compositions or from a separation stream separated from a composition. In some embodiments, filamentous fungus used in the production of the mold-fermented composition is specifically targeted for separation. Incorporation of separated waste components into various products are also described herein. In some embodiments, the separated components are used in alternative meat products and other foods designed for human consumption. Separated components can also be used in animal feed, as feed stock for other fermentation processes, or for use in treating food, creating cosmetics, or chemical processes.Type: ApplicationFiled: June 19, 2020Publication date: December 24, 2020Inventors: Kimberlie Le, Joshua Nixon
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Publication number: 20200399571Abstract: A cell culturing device and method of using same are provided. Embodiments of the cell culturing device include a plate having at least one well with a through-hole formed at a bottom wall thereof and a hydrogel matrix disposed in the through hole. The cell culturing device can also include an optically transparent plate at the bottom of the through-hole.Type: ApplicationFiled: July 22, 2020Publication date: December 24, 2020Inventors: Mordechai Deutsch, Naomi Zurgil, Elena Afrimzon, Sergei Moshkov, Orit Ravid-Hermesh, Yana Shafran, Maria Sobolev
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Publication number: 20200399572Abstract: Disclosed is a disposable cell culture bag capable of facilitating cell culture by using a flexible transparent resin film, the disposable cell culture bag including a body having a sealed space for accommodating a medium, and made of a flexible transparent resin film usable for disposable products, and one or more tubing lines extending from an inside to an outside of the body, wherein the body includes a bottom-side integrated part provided by extending one or more side surfaces from a bottom surface of the body to be spread in a radial shape, in order to obtain continuously smooth four edges of the bottom surface, and a top surface fusion bonded to the side surfaces of the bottom-side integrated part after the side surfaces are fusion bonded to each other.Type: ApplicationFiled: February 15, 2019Publication date: December 24, 2020Inventor: Kyung Nam KIM
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Publication number: 20200399573Abstract: Provided herein are methods for culturing patient-derived tumor cell spheroids in a three-dimensional microfluidic device. The method comprises mincing primary tumor sample in a medium supplemented with serum; treating the minced primary tumor sample with a composition comprising an enzyme; collecting tumor spheroids having a diameter of 10 ?m to 500 ?m from the enzyme treated sample; suspending the tumor spheroids in biocompatible gel; and culturing the tumor spheroids in a three dimensional microfluidic device. Methods for identifying an agent for treating cancer and microfluidic devices that allow for the simultaneous exposure of the cultured patient-derived primary tumor cell spheroids to a treatment of choice and to control treatment are also provided.Type: ApplicationFiled: October 2, 2019Publication date: December 24, 2020Applicant: Dana-Farber Cancer Institute, Inc.Inventors: David Barbie, Amir Aref, Thanh Barbie, Russell W. Jenkins, Kwok-kin Wong
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Publication number: 20200399574Abstract: A device for growing microorganisms is provided. The device includes a body member comprising a self-supporting, waterproof substrate, a layer of adhesive disposed on the substrate, a powder adhered to the adhesive, a cover sheet adhered to the body member, and a dry composition including a mixture of hydroxypropylmethylcellulose and guar gum adhered to the cover sheet or the substrate. The powder comprises a cold-water-soluble gelling agent and one or more nutrient for growing microorganisms. The composition, when reconstituted with water, resists liquefaction by microorganisms A method of culturing microorganisms using the device is also provided.Type: ApplicationFiled: December 12, 2018Publication date: December 24, 2020Inventors: Jason W. Bjork, Sailaja Chandrapati
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Publication number: 20200399575Abstract: A biocompatible composite element for a bioreactor is provided that includes an outer frame and an inner component. The outer frame is a polymeric material. The outer frame can be inseparably attached to a wall of the bioreactor. The inner component is a transparent material selected from a group consisting of glass, sapphire, and glass ceramic. The inner component is secured in the outer component in an inseparable hermetically tight manner. The inner component is configured for a spectral process control through the transparent material of the inner component.Type: ApplicationFiled: June 5, 2020Publication date: December 24, 2020Applicant: SCHOTT AGInventors: Christian Ott, Robert Hettler, Christoph Stangl, Helena Blümel, Reinhard Ecker
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Publication number: 20200399576Abstract: A scaffolding material for culturing a cell, the scaffolding material for culturing a cell containing a synthetic resin, and having a nitrogen content of the synthetic resin of 0.1% by mass or more and 10% by mass or less. According to the scaffolding material for cell culture, the scaffolding material can have suitable hydrophilicity and strength, high fixation of cells after seeding, and highly efficient cell proliferation.Type: ApplicationFiled: July 2, 2020Publication date: December 24, 2020Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Satoshi HANEDA, Yuriko MANABE, Ryoma ISHII, Hiroki IGUCHI, Hiroshi YAMAUCHI, Takahiro OMURA
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Publication number: 20200399577Abstract: This invention relates to a sampling device comprising a shaft and a sample collection portion removably connected with the shaft, wherein the connection site between the shaft and the sample collection portion is weakened. The invention relates also to a combination of a sampling device comprising a shaft and a removable sample collection portion and a sample vessel configured to receive sample collection portion from the shaft.Type: ApplicationFiled: April 3, 2020Publication date: December 24, 2020Inventor: Lauri PELTOSAARI
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Publication number: 20200399578Abstract: Disclosed are a system, device, and method for the electroporation of cells. Systems, devices and methods for electroporation of living cells and the introduction of selected molecules into the cells utilizes a fluidic system where living cells and biologically active molecules flow through a channel that exposes them to electric fields, causing the molecules to be transferred across the cell membrane. The methods are particularly well suited for the introduction of DNA, RNA, drug compounds, and other biologically active molecules into living cells for use in cell-based therapies.Type: ApplicationFiled: May 18, 2020Publication date: December 24, 2020Inventors: Tom Corso, Harold G. Craighead
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Publication number: 20200399579Abstract: The present disclosure provides a flow-through electroporation device configured for use in an automated multi-module cell processing environment and configured to decrease cell processing time and the risk of clogging.Type: ApplicationFiled: June 17, 2020Publication date: December 24, 2020Inventors: Nathan Bade, Jorge Bernate, Phillip Belgrader, Don Masquelier
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Publication number: 20200399580Abstract: A system for controlling a motion of a cell culture includes a tray adapted to hold a cell culture, a camera adapted to capture an image of the cell culture, and a device adapted to control a movement of the tray. The system also includes a processor adapted to determine a first movement of the tray, receive from the camera data representing an image of the cell culture, determine a characteristic of the cell culture based on the image data, determine a second movement of the tray based on the characteristic, the second movement being different from the first movement, and cause the tray to move in accordance with the second movement.Type: ApplicationFiled: August 31, 2020Publication date: December 24, 2020Inventors: Francesco ARMANI, Giacomo CATTARUZZI, Francesco CURCIO, Massimo MORETTI, Antonio SFILIGOJ, Piero FISSORE
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Publication number: 20200399581Abstract: The invention provides a technology for promptly determining bacterial identification or an antimicrobial susceptibility testing. In the invention, first, a state where the bacteria are divided is monitored by performing microscopic observation with respect to the shape or the number of bacteria in each of wells of a culture plate for bacterial identification culture or the antimicrobial susceptibility testing. In addition, the shape, the number or the area of the bacteria are interpreted from the image obtained by the microscopic observation whether or not the bacteria proliferate at a stage from an induction phase to a logarithmic phase, and the time-dependent changes thereof are made into a graph. From the graph, it is determined whether or not the bacteria proliferate for each measurement, the determination results are displayed on the screen, and accordingly, the result of the antimicrobial susceptibility is provided every time when the measurement is performed.Type: ApplicationFiled: September 2, 2020Publication date: December 24, 2020Applicant: HITACHI HIGH-TECH CORPORATIONInventors: Chihiro UEMATSU, Muneo MAESHIMA
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Publication number: 20200399582Abstract: A system for enabling a wireless single use sensing sub-system by optimizing electrical power is presented. The system includes the sensing sub-system configured to be employed in a bio process environment. Further, the sensing sub-system includes a sensing unit configured to measure at least one parameter of the bio process environment. Also, the sensing sub-system includes a power source electrically coupled to the sensing unit and configured to transmit an electrical power to the sensing unit. Furthermore, the sensing sub-system includes a switch configured to electrically couple or decouple the sensing unit from the power source. In addition, the system includes a control sub-system including a first controller configured to determine at least one power control parameter based on a user-input data and a sensing sub-system data, and optimize consumption of the electrical power in the sensing sub-system, based on the power control parameter.Type: ApplicationFiled: April 18, 2018Publication date: December 24, 2020Inventors: Victor Jose, Veena B N Rao, Hanish Lakhani
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Publication number: 20200399583Abstract: Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the cells through an acoustophoretic device having an ultrasonic transducer including a piezoelectric material driven by a drive signal to create a multi-dimensional acoustic standing wave. A drive signal is sent to drive the at least one ultrasonic transducer to create the multi-dimensional acoustic standing wave. A recirculating fluid stream having a tangential flow path is located substantially tangential to the standing wave and separated therefrom by an interface region. A portion of the cells pass through the standing wave, and the beads are held back from the standing wave in the recirculating fluid stream at the interface region. Also disclosed is an acoustophoretic device having a coolant inlet adapted to permit the ingress of a cooling fluid into the device for cooling the transducer.Type: ApplicationFiled: May 28, 2020Publication date: December 24, 2020Inventors: Bart Lipkens, Rudolf Gilmanshin, Louis Masi, Benjamin Ross-Johnsrud, Erik Miller, Walter M. Presz, JR., Thomas J. Kennedy, III
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Publication number: 20200399584Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.Type: ApplicationFiled: September 4, 2020Publication date: December 24, 2020Inventors: Phillip Belgrader, Don Masquelier, Andrew Garst, Richard Fox
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Publication number: 20200399585Abstract: Provided is a product production method which includes: a step of culturing a cell which produces a product and is contained in a cell suspension accommodated in a culture vessel; a separation treatment step of extracting the cell suspension from the culture vessel and separating the cell suspension by a tangential filtration method using a separation membrane; a step of returning a return liquid to the culture vessel; a step of supplying a fresh medium into the culture vessel; and a step of collecting the product, and in which with respect to a live cell concentration Nc, a pore diameter Dp of the separation membrane, a filtration area S of the separation membrane, and a volume Vf of a primary side flow path of the separation membrane, a number density Nd of fine particles having a particle size of 8 Dp to 30 Dp other than live cells in the cell suspension satisfies Nc?Nd?S/(32×?×Vf×Dp2).Type: ApplicationFiled: September 8, 2020Publication date: December 24, 2020Applicant: FUJIFILM CorporationInventors: Naoto TAKAHASHI, Shinichi NAKAI