Patents Issued in January 12, 2021
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Patent number: 10888610Abstract: The present invention relates to an immunogenic complex comprising an amino acid sequence having at least 80% sequence identity with the amino acid sequence of the N-terminal region of a group B Streptococcus surface protein, and a capsular polysaccharide. The immunogenic complex is capable of eliciting protective immunity against group B Streptococcus. The invention further pertains to an immunogenic product comprising the immunogenic complex and an immunogenic fusion protein, the vaccine, the immunogenic complex, or the immunogenic product for use in a method of preventing or treating a group B Streptococcus infection, as well as a method of preventing or treating a group B Streptococcus infection.Type: GrantFiled: December 14, 2016Date of Patent: January 12, 2021Inventor: Per Bo Pedersen Fischer
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Patent number: 10888611Abstract: In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 ?g/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 ?g/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.Type: GrantFiled: February 16, 2016Date of Patent: January 12, 2021Assignee: PFIZER INC.Inventors: Kathrin Ute Jansen, Annaliesa Sybil Anderson, Rasappa Gounder Arumugham, John Erwin Farley, Leah Diane Fletcher, Shannon Lea Harris, Thomas Richard Jones, Lakshmi Khandke, Bounthon Loun, John Lance Perez, Gary Warren Zlotnick
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Patent number: 10888612Abstract: The present invention relates to vaccines of DNA that code for specific viral sequences. The DNA vaccines against yellow fever according to the invention are based on the sequence that codes for the yellow fever virus envelope protein (p/YFE). Besides the wild p/YFE construct, sequence E was also fused with the sequence that codes for the human lysosome-associated membrane protein (h-LAMP), generating the construct (pL/YFE). The results of the invention are considered to be very promising, since both constructs can induce T-cell response against the same epitopes induced by the 17DD vaccine, and the pL/YFE construct can also induce a satisfactory concentration of neutralizing antibodies. The pL/YFE vector was inoculated in mice, before intracerebral challenge with the virus of yellow fever. Surprisingly, 100% of the mice immunized with pL/YFE survived the challenge.Type: GrantFiled: September 28, 2018Date of Patent: January 12, 2021Assignee: The Johns Hopkins UniversityInventors: Ernesto Torres de Azevedo Marques, Rafael Dhalia, Romulo Maciel Filho
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Patent number: 10888613Abstract: The present invention relates generally to immunotherapy for preventing HIV infection in HIV-negative individuals. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.Type: GrantFiled: January 11, 2017Date of Patent: January 12, 2021Assignee: American Gene Technologies International Inc.Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen
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Patent number: 10888614Abstract: Emulsifiers for emulsions vaccine formulations and use in water-in-oil emulsion for vaccine formulations as an emulsifier. The emulsifier is an alkoxylated polyol or polyamine which is optionally acyl terminated. There is also provided a method of forming the vaccine formulation. The emulsifiers provide for emulsions which may require less emulsifier than known emulsifiers, and provide stable emulsions.Type: GrantFiled: April 4, 2016Date of Patent: January 12, 2021Inventors: Roberta Ondei, Edna Fernandes
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Patent number: 10888615Abstract: Provided herein is a human monoclonal antibody 8D6 against hepatitis C virus (HCV) infection. The antibody binds to the E2 subunit of HCV capsid protein, and can prevent HCV from infecting susceptible host cells. By using the antibody variable region gene or the complementary determining region (CDR) gene, different forms of genetic engineering antibodies have been transformed and produced in any expression system of the prokaryotic and eukaryotic cells as therapeutics to prevent or treat HCV infection.Type: GrantFiled: April 21, 2017Date of Patent: January 12, 2021Assignee: SUZHOU GALAXY BIOPHARMA, CO., LTD.Inventors: Honglin Zhou, Jie Liu, Xin Dong, Bing Sun, Jiangjun Wang, Zhiyang Ling, Chunyan Yi, Chao Bian
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Patent number: 10888616Abstract: This invention relates to ready-to-use and safe solution compositions of glucagon suitable for administration by manual injection or by an insulin pump or other injection device to treat hypoglycemia. Said compositions comprise glucagon, an acid, anti-gelling polyol, a stabilizing-salt, viscosity reducer and an antioxidant, have a final pH between about 2 and 5, and is gel-free, chemically-stable, and pump-able.Type: GrantFiled: February 22, 2018Date of Patent: January 12, 2021Assignee: LATITUDE PHARMACEUTICALS, INC.Inventors: Hailiang Chen, Andrew Xian Chen, Norman Keith Orida
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Patent number: 10888617Abstract: The present invention is generally directed to materials, gels, coatings and films prepared using a biomaterial (e.g., a fatty acid-based material comprising a network of cross-linked fatty acids) and a fixating material, layer or film (e.g., a fixating material comprising Na-CMC). The materials, gels, coatings and films disclosed herein can be used to facilitate the delivery of one or more therapeutic agents to a targeted tissue and a desired rate of release.Type: GrantFiled: November 21, 2017Date of Patent: January 12, 2021Assignee: ATRIUM MEDICAL CORPORATIONInventors: Keith M. Faucher, Suzanne Conroy, Theresa K. Albergo, Joseph Bienkiewicz
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Patent number: 10888618Abstract: The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and optionally in further combination with local administration of an immunotherapeutic agent, such as a cancer vaccine or NKT agonist. The invention also provides a method for treating cancer using an intracellular penetration enhancing agent. The methods of the invention aim to substantially kill and/or destroy the target tumor cells, as well as those cancerous cells that have metastasized to other parts of the body.Type: GrantFiled: February 24, 2017Date of Patent: January 12, 2021Assignee: Intensity Therapeutics, Inc.Inventor: Lewis H. Bender
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Patent number: 10888619Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.Type: GrantFiled: June 14, 2019Date of Patent: January 12, 2021Assignee: Coherus BioSciences, Inc.Inventors: Mark Manning, Brian Murphy
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Patent number: 10888620Abstract: Compositions useful in the treatment of cough and cold symptoms, including but not limited to, cough, nasal congestion and sore throat, are disclosed.Type: GrantFiled: November 28, 2017Date of Patent: January 12, 2021Assignee: Johnson & Johnson Consumer Inc.Inventors: Gerard P. McNally, Anurag Pandey, Vipul Dave
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Patent number: 10888621Abstract: Provided are an injectable tissue adhesive hydrogel including gamma-cyclodextrin (?-CD). When such an injectable tissue adhesive hydrogel including the ?-CD is used as a skin glue, based on a fact that the ?-CD has a bigger hydrophobic cavity than that of ?- and ?-CDs, the injectable tissue adhesive hydrogel including the ?-CD has stronger interactions than host-guest interactions. In addition, hydrogen bonding in the injectable tissue adhesive hydrogel including the ?-CD can improve both cohesiveness and adhesiveness of gelatin. The injectable tissue adhesive hydrogel including the ?-CD having excellent cell viability is used for adhesion of a skin incision, to thereby effectively promote tissue regeneration.Type: GrantFiled: March 31, 2017Date of Patent: January 12, 2021Assignees: AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION, INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATIONInventors: Ki Dong Park, Kyung Min Park, Yun Ki Lee, Thi Thai Thanh Hoang, Thi Phuong Le
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Patent number: 10888622Abstract: A nanocomplex containing a delivery agent and a pharmaceutical agent. The nanocomplex has a particle size of 50 to 1000 nm, the delivery agent binds to the pharmaceutical agent via non-covalent interaction or covalent bonding, and the pharmaceutical agent is a modified peptide or protein formed of a peptide or protein and an added chemical moiety that contains an anionic group, a disulfide group, a hydrophobic group, a pH responsive group, a light responsive group, a reactive oxygen species responsive group, or a combination thereof.Type: GrantFiled: May 13, 2014Date of Patent: January 12, 2021Assignee: Trustees of Tufts CollegeInventors: Qiaobing Xu, Ming Wang
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Patent number: 10888623Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.Type: GrantFiled: April 23, 2019Date of Patent: January 12, 2021Assignee: Redwood Bioscience, Inc.Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka
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Patent number: 10888624Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.Type: GrantFiled: April 5, 2019Date of Patent: January 12, 2021Assignee: ASTRAZENECA ABInventors: Marianne Bernice Ashford, Iain Grant, Edward John Hennessy, William McCoull, Michael Giannis, Brian Kelly, David Owen, John Paul Secrist
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Patent number: 10888625Abstract: A targeted drug delivery complex containing a particle, a targeting moiety electrostatically attached to the particle, and an active pharmaceutical ingredient attached to or dispersed or dissolved within the particle is provided. Also provided are pharmaceutical formulations containing a plurality of the complexes as well as methods for use in targeting an active pharmaceutical ingredient to a selected cell or tissue and production of such formulations.Type: GrantFiled: October 29, 2013Date of Patent: January 12, 2021Assignee: PARTICLE SCIENCES, INC.Inventors: Mark Mitchnick, Garry Gwozdz, Andrew Loxley
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Patent number: 10888626Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.Type: GrantFiled: July 16, 2020Date of Patent: January 12, 2021Assignee: Translate Bio, Inc.Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
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Patent number: 10888627Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.Type: GrantFiled: June 14, 2019Date of Patent: January 12, 2021Assignee: Factor Bioscience Inc.Inventors: Matthew Angel, Christopher Rohde
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Patent number: 10888628Abstract: Compositions and regimens useful in treating hemophilia A are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving expression of a human Factor VIII.Type: GrantFiled: November 22, 2019Date of Patent: January 12, 2021Assignee: The Trustees of the University of PennsylvaniaInventors: Lili Wang, James M. Wilson, Jenny Agnes Sidrane
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Patent number: 10888629Abstract: Compositions and methods for visualizing tissue under illumination with fusion compounds of near-infrared radiation using near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are provided.Type: GrantFiled: October 4, 2019Date of Patent: January 12, 2021Assignee: Intuitive Surgical Operations, Inc.Inventor: Jonathan M. Sorger
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Patent number: 10888630Abstract: There are described magnetic nanoparticles the surface of which is functionalized with catechol and constructs comprising a plurality of said nanoparticles encapsulated in a biocompatible polymer matrix, wherein a molecule with therapeutic action is optionally dispersed, said polymer matrix optionally being in turn further functionalized; there are further described cells of the immune system incorporating said polymeric constructs giving rise to their engineering.Type: GrantFiled: January 7, 2015Date of Patent: January 12, 2021Assignee: COLOROBBIA ITALIA S.P.A.Inventors: Giovanni Baldi, Costanza Ravagli, Mauro Comes Franchini, Mario Milco D'Elios, Marisa Benagiano, Marco Bitossi
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Patent number: 10888631Abstract: The present invention relates to a method for sterilisation of phospholipid suspensions, useful in the preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method provides sterility assurance, without undue thermal degradation of the phospholipid. The method is also amenable to commercial scale manufacture. Also provided are methods of preparing kits and ultrasound contrast agents incorporating the sterilisation method of the invention.Type: GrantFiled: June 26, 2015Date of Patent: January 12, 2021Assignee: GE HEALTHCARE ASInventors: Svein Kvale, Ingrid Henriksen, Ole Johannes Tokerud, Per Sontum
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Patent number: 10888632Abstract: A ultraviolet sanitation system including a towel assembly, a body configured to be an upward facing hollow-half-sphere and to contain a sanitizing liquid, a plate including two grooves, each of the grooves configured to accept a t-handle and a roller-ball of the towel assembly with the plate affixable to the body, and a plurality of wringing-rollers within the body beneath the plate configured to remove excess moisture from the towel assembly during use. Also include is an arm-assembly affixable to the base configured to restrain the plate, a sanitizing ultraviolet-light-source contained with the body below the plate, a base affixable to a bottom of the body, and a power-source electrically coupled to said ultraviolet-light-source.Type: GrantFiled: October 2, 2017Date of Patent: January 12, 2021Inventor: Mitchell James Masyk
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Patent number: 10888633Abstract: A freshening composition is provided. The composition includes at least one particle, and an aqueous carrier. The composition includes a polysaccharide system having a first polysaccharide and a second polysaccharide. The first polysaccharide is xanthan gum and the second polysaccharide is selected from the group consisting of konjac gum, locust bean gum, and combinations thereof. The composition may include an unencapsulated perfume.Type: GrantFiled: September 10, 2018Date of Patent: January 12, 2021Assignee: The Procter & Gamble CompanyInventors: Matthew Lawrence Lynch, Carla Jean Colina, Steven Anthony Horenziak, Brandon Philip Illie, Yonas Gizaw, Yiping Sun
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Patent number: 10888634Abstract: Atomizers and methods for operating atomizers for dispersing vapor into the ambient air are disclosed. Liquid from a vessel connected to the atomizer may be pumped to a first chamber having an atomizing element at or near the bottom of the first chamber. The atomizing element may convert the liquid to a vapor, and a fan may push air into the first chamber, causing the vapor to be dispersed into the ambient air through apertures at or near the top of the first chamber. Liquid remaining in the first chamber may be pumped back to the vessel, while the fan continues to run to dry the components in the first chamber.Type: GrantFiled: September 28, 2020Date of Patent: January 12, 2021Assignees: Ideal Jacobs Corp., Wistwell, Inc.Inventors: Andrew C. Jacobs, Todd Sherman, Nicholas John Rafanello
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Patent number: 10888635Abstract: An absorbent article includes a chassis comprising a topsheet, a backsheet, and an absorbent core disposed between the topsheet and backsheet. The absorbent core contains superabsorbent polymer material and about 10% or less by weight of cellulosic fibers. The backsheet comprises a film comprising a plurality of micropores. The film comprises odor absorbing material disposed in one or more of the micropores.Type: GrantFiled: June 5, 2017Date of Patent: January 12, 2021Assignee: The Procter & Gamble CompanyInventors: Clarissa Maldonado, Kun Sun, Johannson Jimmy Tee, Jr., Norman Scott Broyles
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Patent number: 10888636Abstract: Various embodiments disclosed relate to curable calcium phosphate compositions for use with porous structures and methods of using the same. In various embodiments, the present invention provides a curable calcium phosphate composition or a cured product thereof, with the curable calcium phosphate composition including calcium phosphate and a perfusion modifier. In various embodiments, the present invention provides an apparatus comprising a porous structure at least partially in contact with the curable calcium phosphate composition or a cured product thereof. The porous structure can include a porous substrate including a plurality of ligaments that define pores of the porous substrate, and a biocompatible metal coating on the plurality of ligaments of the porous substrate.Type: GrantFiled: October 7, 2016Date of Patent: January 12, 2021Assignee: ZIMMER KNEE CREATIONS, INC.Inventors: Siddhesh Angle, Michael Strunk, Tak Lung Chang, Bradford J. Coale, Greg Stebbins, Imants Liepins
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Patent number: 10888637Abstract: Methods and devices are described for using a controlled extensional strain to organize prefibrillar collagen and/or elastin solutions into an organized array of fibrils. The organized array of collagen fibrils produced by the disclosed methods and devices can be used for tissue engineering applications.Type: GrantFiled: February 25, 2019Date of Patent: January 12, 2021Assignee: Northeastern UniversityInventors: Jeffrey W. Ruberti, Jeffrey Paten
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Patent number: 10888638Abstract: The present invention relates to a method of producing a collagen membrane that has particular mechanical properties.Type: GrantFiled: May 15, 2019Date of Patent: January 12, 2021Inventor: Ming Hao Zheng
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Patent number: 10888639Abstract: Delivery catheters for in situ forming foams are provided. The catheters include, in various embodiments, coatings, valves, mixing structures, exit ports and combinations of the same.Type: GrantFiled: August 29, 2014Date of Patent: January 12, 2021Assignee: Arsenal Medical, Inc.Inventors: Toby Freyman, Jennifer Mortensen, Jeffrey Groom, II
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Patent number: 10888640Abstract: Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.Type: GrantFiled: April 21, 2016Date of Patent: January 12, 2021Assignee: Urotronic, Inc.Inventors: Lixiao Wang, Peter Barnett
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Patent number: 10888641Abstract: The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or improved integration of the biomaterial into the host tissue and further relates to kits containing the coated biomaterial. The present invention also relates to methods and kits for coating the biomaterial. It is based, at least in part, on the discovery that biomaterial coated with a cytokine eluting coating resulted in the shift of early stage macrophage polarization that were associated with positive long-term effects such as minimized capsule formation and improved tissue quality and composition as compared to uncoated biomaterials.Type: GrantFiled: January 13, 2020Date of Patent: January 12, 2021Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Bryan Nicklaus Brown, Daniel Jordi Hachim Diaz
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Patent number: 10888642Abstract: The present application relates generally to a suction regulator device and, more specifically, to a method and system for signaling responsive to sensing that the suction regulator device has become contaminated.Type: GrantFiled: August 21, 2018Date of Patent: January 12, 2021Inventor: Sarah Corey
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Patent number: 10888643Abstract: An implantable interbody negative pressure device that permits reduced or negative pressure therapies to be applied to a portion of a patient's body. More specifically, the implantable interbody negative pressure device comprises a body portion having a plurality of openings in fluid communication with both an internal passageway and a vacuum source, and that serves as a manifold and permits reduced or negative pressure therapy to be applied to a surgical site, such as a wound or damaged bone. The application of the reduced or negative pressure to the body improves circulation and the disposal of cellular waste, and promotes bone growth and healing.Type: GrantFiled: September 28, 2018Date of Patent: January 12, 2021Inventors: Thomas Zink, Zeshan Hyder, Frank Kuwamura, III, Nicholas Cordaro
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Patent number: 10888644Abstract: A system for treating atrial dysfunction, including heart failure and/or atrial fibrillation, that includes one or more pressurizing elements and control circuitry. The one or more pressurizing elements can comprise one or more balloons and can be configured to be positioned in the left atrium, and optionally the pulmonary artery, of a patient's heart. The one or more pressurizing elements can be coupled to one or more positioning structures that can be configured to position the one or more pressurizing elements in the left atrium, and optionally the pulmonary artery. The control circuitry can be configured to operate the one or more pressurizing elements to decrease or increase pressure and/or volume in the left atrium, and optionally the pulmonary artery, in accordance with different phases of the cardiac cycle.Type: GrantFiled: February 5, 2020Date of Patent: January 12, 2021Assignee: inQB8 Medical Technologies, LLCInventors: J. Brent Ratz, Arshad Quadri
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Patent number: 10888645Abstract: A ventricular assist device is disclosed. The ventricular assist device may include a centrifugal pump and a controller. The controller may be configured to cause the centrifugal pump to operate at a first speed above a predetermined flow rate. The controller may also be configured to cause the centrifugal pump to operate at a second speed below the predetermined flow rate, wherein the predetermined flowrate is indicative of a crossover point between systole and diastole phases of a person's cardiac cycle.Type: GrantFiled: October 29, 2018Date of Patent: January 12, 2021Assignee: TC1 LLCInventors: Alexander Medvedev, Muhammad Sami
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Patent number: 10888646Abstract: A method is provided for supporting heart function of a patient. The method comprises the step of securing an intracorporeal device across at least two anatomical walls of the heart, wherein at least one anatomical wall is an intra-cardiac wall and a least one anatomical wall is an extra-cardiac wall.Type: GrantFiled: April 28, 2017Date of Patent: January 12, 2021Assignee: NUHEART ASInventors: Vegard Tuseth, Shawn Patterson, Philip J. Haarstad, Knut Klepsvik
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Patent number: 10888647Abstract: A device for extracorporeal blood treatment, in particular a dialysis device, including an internal fluidic system for a treatment liquid, in particular for a dialysis liquid, the internal fluidic system having at least two liquid connectors for connecting a substantially cylindrical filter element, in particular a dialyzer, to the internal fluidic system for passing a treatment liquid through the filter element, and including a mounting for exchangeably holding the filter element in such a way that the filter element can be connected to the liquid connectors of the internal fluidic system and to an extracorporeal blood line in an intended manner, wherein the mounting for holding the filter element is designed in such a way that a cylinder longitudinal axis of the filter element is substantially horizontally aligned.Type: GrantFiled: June 28, 2018Date of Patent: January 12, 2021Assignee: B. BRAUN AVITUM AGInventor: Kai-Uwe Ritter
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Patent number: 10888648Abstract: The invention relates to devices, systems, and methods for priming, disinfecting, and preparing dialysate and related fluids for use in dialysis. The dialysate and related fluids can be prepared from solutes obtained from infusate containers seated in an infusate caddy. The infusate caddy can be removably positioned in a receiving compartment of a dialysis machine. Similarly, the infusate containers containing the necessary solutes for preparing the dialysate and related fluids can also be removably positioned in the infusate caddy.Type: GrantFiled: July 25, 2016Date of Patent: January 12, 2021Assignee: Medtronic, IncInventors: David B. Lura, Christopher M. Hobot, Martin T. Gerber, Thomas E. Meyer
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Patent number: 10888649Abstract: A dialysis machine (e.g., a peritoneal dialysis machine) may include a housing. The machine may further include a leak detector disposed in the housing, the leak detector being an electrical circuit. In response to fluid contacting the leak detector, a leak in the dialysis machine is detectable. The machine is configured to send a signal based on a short of the electrical circuit from fluid contact with the leak detector to indicate a leak condition.Type: GrantFiled: April 3, 2020Date of Patent: January 12, 2021Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Hernando Garrido, Anthony T. Ortega, Asif A. Khan, John A. Biewer
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Patent number: 10888650Abstract: The present invention relates to medical fluid treatments, such as the treatment of renal failure. More specifically, the present invention relates to the testing of such systems.Type: GrantFiled: June 3, 2016Date of Patent: January 12, 2021Assignee: Debiotech S.A.Inventors: Pierre Thiebaud, Frédéric Neftel
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Patent number: 10888651Abstract: A fluid injector having at least one injector head with a front end configured to releasably receive the at least one syringe is described. The fluid injector further includes at least one pressure jacket releasably associated with the front end of the at least one injector head for securing the at least one syringe during an injection procedure. A connection mechanism releasably connects the at least one pressure jacket to the front end of the at least one injector head. The connection mechanism includes at least one electromagnet.Type: GrantFiled: October 15, 2018Date of Patent: January 12, 2021Assignee: BAYER HEALTHCARE LLCInventors: James Dedig, Ralph Schriver, Patrick Campbell, Herbert Grubic
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Patent number: 10888652Abstract: A foot valve for drip chambers of medical infusion or transfusion apparatuses having an annular valve seat with which a float obturator axially displaceable between a position for closing and a position for opening the valve seat cooperates. A containment cage bush has an elastically deformable lateral wall within which the float obturator floats in a guided fashion, and the lateral wall of the containment bush and the float have respective mutually facing surfaces configured such that a radial deformation of the containment bush applies an axial thrust to the float obturator in the direction of moving it apart from the annular valve seat.Type: GrantFiled: February 1, 2017Date of Patent: January 12, 2021Assignee: INDUSTRIE BORLA S.P.AInventor: Gianni Guala
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Patent number: 10888653Abstract: A pump set for use with a pumping apparatus having a rotor with a plurality of rollers mounted on the rotor rotatable about an axis of rotation is disclosed. The pump set comprises a cassette body comprising a stator member with a fixed portion secured to the cassette body, a second portion opposite the fixed portion, a reaction surface and a second surface opposite the reaction surface, the reaction surface defined between the fixed portion and the second portion, and a tube secured to the cassette body, at least a portion of the tube is disposed against the reaction surface.Type: GrantFiled: February 19, 2019Date of Patent: January 12, 2021Assignee: KPR U.S., LLCInventors: Kenneth M. Breitweiser, James M. Harr, Joel D. Wiesner
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Patent number: 10888655Abstract: Embodiments of the present disclosure enable a user-wearable infusion pump that may have a limited user interface including no display to be paired with a remote control device that can include a remote consumer electronic device such as a smartphone and/or a dedicated remote controller.Type: GrantFiled: July 10, 2019Date of Patent: January 12, 2021Assignee: Tandem Diabetes Care, Inc.Inventors: Jason Farnan, Zion Greenlee, Geoffrey A. Kruse, Michael Michaud
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Patent number: 10888656Abstract: A syringe pump is provided. The syringe pump includes a pump body, a control system, a transmission mechanism, and a propulsion mechanism. The transmission mechanism includes a bracket, a propulsion driving motor, a screw rod, a sliding seat, a half nut, and a clutch driving assembly. The propulsion driving motor configured to drive the screw rod to rotate, the clutch driving assembly is disposed on the sliding seat, and configured to drive the half nut and the screw rod to be engaged and disengaged from each other. The propulsion mechanism includes a connecting rod, a pushing block, a pressure sensing assembly, and a clutch switch. The pressure sensing assembly is disposed on the pushing block and configured to detect pressure of a piston rod of a syringe. The clutch switch is disposed on the pushing block and electrically connected to the clutch driving assembly.Type: GrantFiled: July 20, 2016Date of Patent: January 12, 2021Assignee: MEDCAPTAIN MEDICAL TECHNOLOGY. CO., LTD.Inventors: Shendou Jiang, Pan Hu, Dongcen Li, Qisong Liu
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Patent number: 10888657Abstract: An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.Type: GrantFiled: August 26, 2011Date of Patent: January 12, 2021Assignee: EKOS CORPORATIONInventors: Azita Soltani, Raymond M. Wolniewcz, III, Brenton Nistal, Curtis Genstler, Robert L. Wilcox, Ronald L. Haas
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Patent number: 10888658Abstract: A disposable injector with a piston actuation ram is mounted in a housing, is loaded by a spring energy accumulator and can be unlocked by a displaceable trigger device. The piston actuation ram can be supported by a tensioning rod mounted in the housing. The trigger device comprises a trigger ring displaceable relative to the housing. The tensioning rod can be supported directly or indirectly by a bearing surface of the trigger ring. The bearing surface encloses an angle of between ten degrees and forty five degrees with the longitudinal direction of the disposable injector. The point of the angle lies offset with respect to the trigger ring in the triggering direction of the disposable injector. A disposable injector with increased trigger reliability is developed.Type: GrantFiled: October 25, 2017Date of Patent: January 12, 2021Assignee: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Sara Forghani, Uwe Wortmann, Karsten Heuser, Heiko Spilgies
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Patent number: 10888662Abstract: Apparatus for recording information concerning the use of an injection device, the apparatus comprising: one or more sensors for providing information indicative of how the injection device is used; a processor configured to analyse said information detected by the one or more sensors to determine use information, said use information corresponding to how the injection device is used; and a memory for storing said use information in an image format such that said use information can be retrieved from the memory and displayed in an image.Type: GrantFiled: January 13, 2014Date of Patent: January 12, 2021Assignee: Sanofi-Aventis Deutschland GMBHInventor: George Cave
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Patent number: 10888663Abstract: Provided is a titanium filter for syringes and its manufacturing method, more particularly, a titanium filter for syringes which has an improved filtering power and high safety and its manufacturing method. The titanium filter for syringes comprises: a first body having a hollow hole formed on the inner side thereof; and a second body configured to extend in the longitudinal direction of the first body and to cover one side of the hollow hole, wherein the first body and the second body are composed of titanium powders.Type: GrantFiled: August 13, 2019Date of Patent: January 12, 2021Assignee: HANATECH CO., LTD.Inventors: Chang Hwan Bae, Gun Suk In, Hong Jin Kim, Kwon Ung Hwang