Patents Issued in January 12, 2021
  • Patent number: 10888610
    Abstract: The present invention relates to an immunogenic complex comprising an amino acid sequence having at least 80% sequence identity with the amino acid sequence of the N-terminal region of a group B Streptococcus surface protein, and a capsular polysaccharide. The immunogenic complex is capable of eliciting protective immunity against group B Streptococcus. The invention further pertains to an immunogenic product comprising the immunogenic complex and an immunogenic fusion protein, the vaccine, the immunogenic complex, or the immunogenic product for use in a method of preventing or treating a group B Streptococcus infection, as well as a method of preventing or treating a group B Streptococcus infection.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: January 12, 2021
    Inventor: Per Bo Pedersen Fischer
  • Patent number: 10888611
    Abstract: In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 ?g/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 ?g/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: January 12, 2021
    Assignee: PFIZER INC.
    Inventors: Kathrin Ute Jansen, Annaliesa Sybil Anderson, Rasappa Gounder Arumugham, John Erwin Farley, Leah Diane Fletcher, Shannon Lea Harris, Thomas Richard Jones, Lakshmi Khandke, Bounthon Loun, John Lance Perez, Gary Warren Zlotnick
  • Patent number: 10888612
    Abstract: The present invention relates to vaccines of DNA that code for specific viral sequences. The DNA vaccines against yellow fever according to the invention are based on the sequence that codes for the yellow fever virus envelope protein (p/YFE). Besides the wild p/YFE construct, sequence E was also fused with the sequence that codes for the human lysosome-associated membrane protein (h-LAMP), generating the construct (pL/YFE). The results of the invention are considered to be very promising, since both constructs can induce T-cell response against the same epitopes induced by the 17DD vaccine, and the pL/YFE construct can also induce a satisfactory concentration of neutralizing antibodies. The pL/YFE vector was inoculated in mice, before intracerebral challenge with the virus of yellow fever. Surprisingly, 100% of the mice immunized with pL/YFE survived the challenge.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: January 12, 2021
    Assignee: The Johns Hopkins University
    Inventors: Ernesto Torres de Azevedo Marques, Rafael Dhalia, Romulo Maciel Filho
  • Patent number: 10888613
    Abstract: The present invention relates generally to immunotherapy for preventing HIV infection in HIV-negative individuals. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: January 12, 2021
    Assignee: American Gene Technologies International Inc.
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen
  • Patent number: 10888614
    Abstract: Emulsifiers for emulsions vaccine formulations and use in water-in-oil emulsion for vaccine formulations as an emulsifier. The emulsifier is an alkoxylated polyol or polyamine which is optionally acyl terminated. There is also provided a method of forming the vaccine formulation. The emulsifiers provide for emulsions which may require less emulsifier than known emulsifiers, and provide stable emulsions.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: January 12, 2021
    Inventors: Roberta Ondei, Edna Fernandes
  • Patent number: 10888615
    Abstract: Provided herein is a human monoclonal antibody 8D6 against hepatitis C virus (HCV) infection. The antibody binds to the E2 subunit of HCV capsid protein, and can prevent HCV from infecting susceptible host cells. By using the antibody variable region gene or the complementary determining region (CDR) gene, different forms of genetic engineering antibodies have been transformed and produced in any expression system of the prokaryotic and eukaryotic cells as therapeutics to prevent or treat HCV infection.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: January 12, 2021
    Assignee: SUZHOU GALAXY BIOPHARMA, CO., LTD.
    Inventors: Honglin Zhou, Jie Liu, Xin Dong, Bing Sun, Jiangjun Wang, Zhiyang Ling, Chunyan Yi, Chao Bian
  • Patent number: 10888616
    Abstract: This invention relates to ready-to-use and safe solution compositions of glucagon suitable for administration by manual injection or by an insulin pump or other injection device to treat hypoglycemia. Said compositions comprise glucagon, an acid, anti-gelling polyol, a stabilizing-salt, viscosity reducer and an antioxidant, have a final pH between about 2 and 5, and is gel-free, chemically-stable, and pump-able.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: January 12, 2021
    Assignee: LATITUDE PHARMACEUTICALS, INC.
    Inventors: Hailiang Chen, Andrew Xian Chen, Norman Keith Orida
  • Patent number: 10888617
    Abstract: The present invention is generally directed to materials, gels, coatings and films prepared using a biomaterial (e.g., a fatty acid-based material comprising a network of cross-linked fatty acids) and a fixating material, layer or film (e.g., a fixating material comprising Na-CMC). The materials, gels, coatings and films disclosed herein can be used to facilitate the delivery of one or more therapeutic agents to a targeted tissue and a desired rate of release.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: January 12, 2021
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Keith M. Faucher, Suzanne Conroy, Theresa K. Albergo, Joseph Bienkiewicz
  • Patent number: 10888618
    Abstract: The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and optionally in further combination with local administration of an immunotherapeutic agent, such as a cancer vaccine or NKT agonist. The invention also provides a method for treating cancer using an intracellular penetration enhancing agent. The methods of the invention aim to substantially kill and/or destroy the target tumor cells, as well as those cancerous cells that have metastasized to other parts of the body.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: January 12, 2021
    Assignee: Intensity Therapeutics, Inc.
    Inventor: Lewis H. Bender
  • Patent number: 10888619
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: January 12, 2021
    Assignee: Coherus BioSciences, Inc.
    Inventors: Mark Manning, Brian Murphy
  • Patent number: 10888620
    Abstract: Compositions useful in the treatment of cough and cold symptoms, including but not limited to, cough, nasal congestion and sore throat, are disclosed.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: January 12, 2021
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Gerard P. McNally, Anurag Pandey, Vipul Dave
  • Patent number: 10888621
    Abstract: Provided are an injectable tissue adhesive hydrogel including gamma-cyclodextrin (?-CD). When such an injectable tissue adhesive hydrogel including the ?-CD is used as a skin glue, based on a fact that the ?-CD has a bigger hydrophobic cavity than that of ?- and ?-CDs, the injectable tissue adhesive hydrogel including the ?-CD has stronger interactions than host-guest interactions. In addition, hydrogen bonding in the injectable tissue adhesive hydrogel including the ?-CD can improve both cohesiveness and adhesiveness of gelatin. The injectable tissue adhesive hydrogel including the ?-CD having excellent cell viability is used for adhesion of a skin incision, to thereby effectively promote tissue regeneration.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: January 12, 2021
    Assignees: AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION, INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
    Inventors: Ki Dong Park, Kyung Min Park, Yun Ki Lee, Thi Thai Thanh Hoang, Thi Phuong Le
  • Patent number: 10888622
    Abstract: A nanocomplex containing a delivery agent and a pharmaceutical agent. The nanocomplex has a particle size of 50 to 1000 nm, the delivery agent binds to the pharmaceutical agent via non-covalent interaction or covalent bonding, and the pharmaceutical agent is a modified peptide or protein formed of a peptide or protein and an added chemical moiety that contains an anionic group, a disulfide group, a hydrophobic group, a pH responsive group, a light responsive group, a reactive oxygen species responsive group, or a combination thereof.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: January 12, 2021
    Assignee: Trustees of Tufts College
    Inventors: Qiaobing Xu, Ming Wang
  • Patent number: 10888623
    Abstract: The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: January 12, 2021
    Assignee: Redwood Bioscience, Inc.
    Inventors: Romas Alvydas Kudirka, Aaron Edward Albers, Robyn M. Barfield, David Rabuka
  • Patent number: 10888624
    Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: January 12, 2021
    Assignee: ASTRAZENECA AB
    Inventors: Marianne Bernice Ashford, Iain Grant, Edward John Hennessy, William McCoull, Michael Giannis, Brian Kelly, David Owen, John Paul Secrist
  • Patent number: 10888625
    Abstract: A targeted drug delivery complex containing a particle, a targeting moiety electrostatically attached to the particle, and an active pharmaceutical ingredient attached to or dispersed or dissolved within the particle is provided. Also provided are pharmaceutical formulations containing a plurality of the complexes as well as methods for use in targeting an active pharmaceutical ingredient to a selected cell or tissue and production of such formulations.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: January 12, 2021
    Assignee: PARTICLE SCIENCES, INC.
    Inventors: Mark Mitchnick, Garry Gwozdz, Andrew Loxley
  • Patent number: 10888626
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: January 12, 2021
    Assignee: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Patent number: 10888627
    Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: January 12, 2021
    Assignee: Factor Bioscience Inc.
    Inventors: Matthew Angel, Christopher Rohde
  • Patent number: 10888628
    Abstract: Compositions and regimens useful in treating hemophilia A are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving expression of a human Factor VIII.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: January 12, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Lili Wang, James M. Wilson, Jenny Agnes Sidrane
  • Patent number: 10888629
    Abstract: Compositions and methods for visualizing tissue under illumination with fusion compounds of near-infrared radiation using near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are provided.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: January 12, 2021
    Assignee: Intuitive Surgical Operations, Inc.
    Inventor: Jonathan M. Sorger
  • Patent number: 10888630
    Abstract: There are described magnetic nanoparticles the surface of which is functionalized with catechol and constructs comprising a plurality of said nanoparticles encapsulated in a biocompatible polymer matrix, wherein a molecule with therapeutic action is optionally dispersed, said polymer matrix optionally being in turn further functionalized; there are further described cells of the immune system incorporating said polymeric constructs giving rise to their engineering.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: January 12, 2021
    Assignee: COLOROBBIA ITALIA S.P.A.
    Inventors: Giovanni Baldi, Costanza Ravagli, Mauro Comes Franchini, Mario Milco D'Elios, Marisa Benagiano, Marco Bitossi
  • Patent number: 10888631
    Abstract: The present invention relates to a method for sterilisation of phospholipid suspensions, useful in the preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method provides sterility assurance, without undue thermal degradation of the phospholipid. The method is also amenable to commercial scale manufacture. Also provided are methods of preparing kits and ultrasound contrast agents incorporating the sterilisation method of the invention.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: January 12, 2021
    Assignee: GE HEALTHCARE AS
    Inventors: Svein Kvale, Ingrid Henriksen, Ole Johannes Tokerud, Per Sontum
  • Patent number: 10888632
    Abstract: A ultraviolet sanitation system including a towel assembly, a body configured to be an upward facing hollow-half-sphere and to contain a sanitizing liquid, a plate including two grooves, each of the grooves configured to accept a t-handle and a roller-ball of the towel assembly with the plate affixable to the body, and a plurality of wringing-rollers within the body beneath the plate configured to remove excess moisture from the towel assembly during use. Also include is an arm-assembly affixable to the base configured to restrain the plate, a sanitizing ultraviolet-light-source contained with the body below the plate, a base affixable to a bottom of the body, and a power-source electrically coupled to said ultraviolet-light-source.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: January 12, 2021
    Inventor: Mitchell James Masyk
  • Patent number: 10888633
    Abstract: A freshening composition is provided. The composition includes at least one particle, and an aqueous carrier. The composition includes a polysaccharide system having a first polysaccharide and a second polysaccharide. The first polysaccharide is xanthan gum and the second polysaccharide is selected from the group consisting of konjac gum, locust bean gum, and combinations thereof. The composition may include an unencapsulated perfume.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: January 12, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Matthew Lawrence Lynch, Carla Jean Colina, Steven Anthony Horenziak, Brandon Philip Illie, Yonas Gizaw, Yiping Sun
  • Patent number: 10888634
    Abstract: Atomizers and methods for operating atomizers for dispersing vapor into the ambient air are disclosed. Liquid from a vessel connected to the atomizer may be pumped to a first chamber having an atomizing element at or near the bottom of the first chamber. The atomizing element may convert the liquid to a vapor, and a fan may push air into the first chamber, causing the vapor to be dispersed into the ambient air through apertures at or near the top of the first chamber. Liquid remaining in the first chamber may be pumped back to the vessel, while the fan continues to run to dry the components in the first chamber.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: January 12, 2021
    Assignees: Ideal Jacobs Corp., Wistwell, Inc.
    Inventors: Andrew C. Jacobs, Todd Sherman, Nicholas John Rafanello
  • Patent number: 10888635
    Abstract: An absorbent article includes a chassis comprising a topsheet, a backsheet, and an absorbent core disposed between the topsheet and backsheet. The absorbent core contains superabsorbent polymer material and about 10% or less by weight of cellulosic fibers. The backsheet comprises a film comprising a plurality of micropores. The film comprises odor absorbing material disposed in one or more of the micropores.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: January 12, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Clarissa Maldonado, Kun Sun, Johannson Jimmy Tee, Jr., Norman Scott Broyles
  • Patent number: 10888636
    Abstract: Various embodiments disclosed relate to curable calcium phosphate compositions for use with porous structures and methods of using the same. In various embodiments, the present invention provides a curable calcium phosphate composition or a cured product thereof, with the curable calcium phosphate composition including calcium phosphate and a perfusion modifier. In various embodiments, the present invention provides an apparatus comprising a porous structure at least partially in contact with the curable calcium phosphate composition or a cured product thereof. The porous structure can include a porous substrate including a plurality of ligaments that define pores of the porous substrate, and a biocompatible metal coating on the plurality of ligaments of the porous substrate.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: January 12, 2021
    Assignee: ZIMMER KNEE CREATIONS, INC.
    Inventors: Siddhesh Angle, Michael Strunk, Tak Lung Chang, Bradford J. Coale, Greg Stebbins, Imants Liepins
  • Patent number: 10888637
    Abstract: Methods and devices are described for using a controlled extensional strain to organize prefibrillar collagen and/or elastin solutions into an organized array of fibrils. The organized array of collagen fibrils produced by the disclosed methods and devices can be used for tissue engineering applications.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: January 12, 2021
    Assignee: Northeastern University
    Inventors: Jeffrey W. Ruberti, Jeffrey Paten
  • Patent number: 10888638
    Abstract: The present invention relates to a method of producing a collagen membrane that has particular mechanical properties.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: January 12, 2021
    Inventor: Ming Hao Zheng
  • Patent number: 10888639
    Abstract: Delivery catheters for in situ forming foams are provided. The catheters include, in various embodiments, coatings, valves, mixing structures, exit ports and combinations of the same.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: January 12, 2021
    Assignee: Arsenal Medical, Inc.
    Inventors: Toby Freyman, Jennifer Mortensen, Jeffrey Groom, II
  • Patent number: 10888640
    Abstract: Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: January 12, 2021
    Assignee: Urotronic, Inc.
    Inventors: Lixiao Wang, Peter Barnett
  • Patent number: 10888641
    Abstract: The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or improved integration of the biomaterial into the host tissue and further relates to kits containing the coated biomaterial. The present invention also relates to methods and kits for coating the biomaterial. It is based, at least in part, on the discovery that biomaterial coated with a cytokine eluting coating resulted in the shift of early stage macrophage polarization that were associated with positive long-term effects such as minimized capsule formation and improved tissue quality and composition as compared to uncoated biomaterials.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: January 12, 2021
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Bryan Nicklaus Brown, Daniel Jordi Hachim Diaz
  • Patent number: 10888642
    Abstract: The present application relates generally to a suction regulator device and, more specifically, to a method and system for signaling responsive to sensing that the suction regulator device has become contaminated.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: January 12, 2021
    Inventor: Sarah Corey
  • Patent number: 10888643
    Abstract: An implantable interbody negative pressure device that permits reduced or negative pressure therapies to be applied to a portion of a patient's body. More specifically, the implantable interbody negative pressure device comprises a body portion having a plurality of openings in fluid communication with both an internal passageway and a vacuum source, and that serves as a manifold and permits reduced or negative pressure therapy to be applied to a surgical site, such as a wound or damaged bone. The application of the reduced or negative pressure to the body improves circulation and the disposal of cellular waste, and promotes bone growth and healing.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: January 12, 2021
    Inventors: Thomas Zink, Zeshan Hyder, Frank Kuwamura, III, Nicholas Cordaro
  • Patent number: 10888644
    Abstract: A system for treating atrial dysfunction, including heart failure and/or atrial fibrillation, that includes one or more pressurizing elements and control circuitry. The one or more pressurizing elements can comprise one or more balloons and can be configured to be positioned in the left atrium, and optionally the pulmonary artery, of a patient's heart. The one or more pressurizing elements can be coupled to one or more positioning structures that can be configured to position the one or more pressurizing elements in the left atrium, and optionally the pulmonary artery. The control circuitry can be configured to operate the one or more pressurizing elements to decrease or increase pressure and/or volume in the left atrium, and optionally the pulmonary artery, in accordance with different phases of the cardiac cycle.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: January 12, 2021
    Assignee: inQB8 Medical Technologies, LLC
    Inventors: J. Brent Ratz, Arshad Quadri
  • Patent number: 10888645
    Abstract: A ventricular assist device is disclosed. The ventricular assist device may include a centrifugal pump and a controller. The controller may be configured to cause the centrifugal pump to operate at a first speed above a predetermined flow rate. The controller may also be configured to cause the centrifugal pump to operate at a second speed below the predetermined flow rate, wherein the predetermined flowrate is indicative of a crossover point between systole and diastole phases of a person's cardiac cycle.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: January 12, 2021
    Assignee: TC1 LLC
    Inventors: Alexander Medvedev, Muhammad Sami
  • Patent number: 10888646
    Abstract: A method is provided for supporting heart function of a patient. The method comprises the step of securing an intracorporeal device across at least two anatomical walls of the heart, wherein at least one anatomical wall is an intra-cardiac wall and a least one anatomical wall is an extra-cardiac wall.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: January 12, 2021
    Assignee: NUHEART AS
    Inventors: Vegard Tuseth, Shawn Patterson, Philip J. Haarstad, Knut Klepsvik
  • Patent number: 10888647
    Abstract: A device for extracorporeal blood treatment, in particular a dialysis device, including an internal fluidic system for a treatment liquid, in particular for a dialysis liquid, the internal fluidic system having at least two liquid connectors for connecting a substantially cylindrical filter element, in particular a dialyzer, to the internal fluidic system for passing a treatment liquid through the filter element, and including a mounting for exchangeably holding the filter element in such a way that the filter element can be connected to the liquid connectors of the internal fluidic system and to an extracorporeal blood line in an intended manner, wherein the mounting for holding the filter element is designed in such a way that a cylinder longitudinal axis of the filter element is substantially horizontally aligned.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: January 12, 2021
    Assignee: B. BRAUN AVITUM AG
    Inventor: Kai-Uwe Ritter
  • Patent number: 10888648
    Abstract: The invention relates to devices, systems, and methods for priming, disinfecting, and preparing dialysate and related fluids for use in dialysis. The dialysate and related fluids can be prepared from solutes obtained from infusate containers seated in an infusate caddy. The infusate caddy can be removably positioned in a receiving compartment of a dialysis machine. Similarly, the infusate containers containing the necessary solutes for preparing the dialysate and related fluids can also be removably positioned in the infusate caddy.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: January 12, 2021
    Assignee: Medtronic, Inc
    Inventors: David B. Lura, Christopher M. Hobot, Martin T. Gerber, Thomas E. Meyer
  • Patent number: 10888649
    Abstract: A dialysis machine (e.g., a peritoneal dialysis machine) may include a housing. The machine may further include a leak detector disposed in the housing, the leak detector being an electrical circuit. In response to fluid contacting the leak detector, a leak in the dialysis machine is detectable. The machine is configured to send a signal based on a short of the electrical circuit from fluid contact with the leak detector to indicate a leak condition.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: January 12, 2021
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Hernando Garrido, Anthony T. Ortega, Asif A. Khan, John A. Biewer
  • Patent number: 10888650
    Abstract: The present invention relates to medical fluid treatments, such as the treatment of renal failure. More specifically, the present invention relates to the testing of such systems.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: January 12, 2021
    Assignee: Debiotech S.A.
    Inventors: Pierre Thiebaud, Frédéric Neftel
  • Patent number: 10888651
    Abstract: A fluid injector having at least one injector head with a front end configured to releasably receive the at least one syringe is described. The fluid injector further includes at least one pressure jacket releasably associated with the front end of the at least one injector head for securing the at least one syringe during an injection procedure. A connection mechanism releasably connects the at least one pressure jacket to the front end of the at least one injector head. The connection mechanism includes at least one electromagnet.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: January 12, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: James Dedig, Ralph Schriver, Patrick Campbell, Herbert Grubic
  • Patent number: 10888652
    Abstract: A foot valve for drip chambers of medical infusion or transfusion apparatuses having an annular valve seat with which a float obturator axially displaceable between a position for closing and a position for opening the valve seat cooperates. A containment cage bush has an elastically deformable lateral wall within which the float obturator floats in a guided fashion, and the lateral wall of the containment bush and the float have respective mutually facing surfaces configured such that a radial deformation of the containment bush applies an axial thrust to the float obturator in the direction of moving it apart from the annular valve seat.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: January 12, 2021
    Assignee: INDUSTRIE BORLA S.P.A
    Inventor: Gianni Guala
  • Patent number: 10888653
    Abstract: A pump set for use with a pumping apparatus having a rotor with a plurality of rollers mounted on the rotor rotatable about an axis of rotation is disclosed. The pump set comprises a cassette body comprising a stator member with a fixed portion secured to the cassette body, a second portion opposite the fixed portion, a reaction surface and a second surface opposite the reaction surface, the reaction surface defined between the fixed portion and the second portion, and a tube secured to the cassette body, at least a portion of the tube is disposed against the reaction surface.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: January 12, 2021
    Assignee: KPR U.S., LLC
    Inventors: Kenneth M. Breitweiser, James M. Harr, Joel D. Wiesner
  • Patent number: 10888655
    Abstract: Embodiments of the present disclosure enable a user-wearable infusion pump that may have a limited user interface including no display to be paired with a remote control device that can include a remote consumer electronic device such as a smartphone and/or a dedicated remote controller.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: January 12, 2021
    Assignee: Tandem Diabetes Care, Inc.
    Inventors: Jason Farnan, Zion Greenlee, Geoffrey A. Kruse, Michael Michaud
  • Patent number: 10888656
    Abstract: A syringe pump is provided. The syringe pump includes a pump body, a control system, a transmission mechanism, and a propulsion mechanism. The transmission mechanism includes a bracket, a propulsion driving motor, a screw rod, a sliding seat, a half nut, and a clutch driving assembly. The propulsion driving motor configured to drive the screw rod to rotate, the clutch driving assembly is disposed on the sliding seat, and configured to drive the half nut and the screw rod to be engaged and disengaged from each other. The propulsion mechanism includes a connecting rod, a pushing block, a pressure sensing assembly, and a clutch switch. The pressure sensing assembly is disposed on the pushing block and configured to detect pressure of a piston rod of a syringe. The clutch switch is disposed on the pushing block and electrically connected to the clutch driving assembly.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: January 12, 2021
    Assignee: MEDCAPTAIN MEDICAL TECHNOLOGY. CO., LTD.
    Inventors: Shendou Jiang, Pan Hu, Dongcen Li, Qisong Liu
  • Patent number: 10888657
    Abstract: An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: January 12, 2021
    Assignee: EKOS CORPORATION
    Inventors: Azita Soltani, Raymond M. Wolniewcz, III, Brenton Nistal, Curtis Genstler, Robert L. Wilcox, Ronald L. Haas
  • Patent number: 10888658
    Abstract: A disposable injector with a piston actuation ram is mounted in a housing, is loaded by a spring energy accumulator and can be unlocked by a displaceable trigger device. The piston actuation ram can be supported by a tensioning rod mounted in the housing. The trigger device comprises a trigger ring displaceable relative to the housing. The tensioning rod can be supported directly or indirectly by a bearing surface of the trigger ring. The bearing surface encloses an angle of between ten degrees and forty five degrees with the longitudinal direction of the disposable injector. The point of the angle lies offset with respect to the trigger ring in the triggering direction of the disposable injector. A disposable injector with increased trigger reliability is developed.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: January 12, 2021
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Sara Forghani, Uwe Wortmann, Karsten Heuser, Heiko Spilgies
  • Patent number: 10888662
    Abstract: Apparatus for recording information concerning the use of an injection device, the apparatus comprising: one or more sensors for providing information indicative of how the injection device is used; a processor configured to analyse said information detected by the one or more sensors to determine use information, said use information corresponding to how the injection device is used; and a memory for storing said use information in an image format such that said use information can be retrieved from the memory and displayed in an image.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: January 12, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: George Cave
  • Patent number: 10888663
    Abstract: Provided is a titanium filter for syringes and its manufacturing method, more particularly, a titanium filter for syringes which has an improved filtering power and high safety and its manufacturing method. The titanium filter for syringes comprises: a first body having a hollow hole formed on the inner side thereof; and a second body configured to extend in the longitudinal direction of the first body and to cover one side of the hollow hole, wherein the first body and the second body are composed of titanium powders.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: January 12, 2021
    Assignee: HANATECH CO., LTD.
    Inventors: Chang Hwan Bae, Gun Suk In, Hong Jin Kim, Kwon Ung Hwang