Abstract: An adapter for use with an appliance for administering an injectable product, the adapter serving to create a product connection between a catheter and a product container that can be inserted into the appliance, and including a thread for screwing the adapter to the appliance, a stop for fixing the container in the longitudinal direction of the thread, an attachment piece to which the catheter may be connected, and a product channel that extends through the attachment piece and the thread.

Abstract: Provided is a system and method for multi-modal dosing of a product. The system provides a control base for coupling to one of a plurality of different cartridges containing product, at least two cartridges having different modalities of delivery—the coupled control base and selected cartridge providing a dosing device. Each cartridge has at least a unique identifier, which may be read by the control base and correlated through a database to confirm that the user is authorized to use the cartridge, and use of the cartridge for a dose of product will not conflict with other products received by the user and known to the system. Cartridges that are not coupled to the control base are non-functional and cannot dispense product as intended with the system. An associated method of use is also provided.

Abstract: Provided is a system and method for multi-modal dosing of a product. The system provides a control base for coupling to one of a plurality of different cartridges containing product, at least two cartridges having different modalities of delivery—the coupled control base and selected cartridge providing a dosing device. Each cartridge has at least a unique identifier, which may be read by the control base and correlated through a database to confirm that the user is authorized to use the cartridge, and use of the cartridge for a dose of product will not conflict with other products received by the user and known to the system. Cartridges that are not coupled to the control base are non-functional and cannot dispense product as intended with the system. An associated method of use is also provided.

Abstract: A supplementary device for a manually operable injection device, the supplementary device including a body having at least one engaging member to releasably mount the body to the injection device in a specific position on an outside surface of the injection device, and at least one indicator located on the body and having a shape or contour to overlap or to align with a mark on the outside surface of the injection device when the body is in or near the specific position.

Abstract: The disclosure relates to a drug delivery device including a plunger disposed within a case and an audible indicator that comprises a resilient element. The plunger is slidable from a proximal position to a distal position within the case and the resilient element is in a first configuration when the plunger is in the proximal position, such that the resilient element is deflected radially outwards to a second configuration during movement of the plunger from the proximal position towards the distal position. The resilient element moves from the second configuration towards the first configuration when the plunger moves towards or reaches the distal position, thereby generating an audible and tactile signal.

Abstract: A drug delivery device comprising a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, an audible indicator that is arranged within a case pocket lateral to the plunger and that is in operative connection with the plunger, the audible indicator comprises at least one indicator spring and at least one locking element. The indicator spring is biased by the locking element, and the indicator spring relaxes due to a release of the locking element by a movement of the plunger.

Abstract: A needle safety system for a syringe having a generally cylindrical barrel extending along a longitudinal axis, the barrel having a hub from which a needle extends distally. The needle safety device has a sleeve at least partially enclosing the needle. A guide track is formed in the sleeve. A multi-part collar disposed in the sleeve has an inner collar which is fixedly connectable to the hub of a syringe barrel. An outer collar is rotatably attached to the inner collar. A guide pin extending radially outwardly from the outer collar slideably engages the guide track. A torqueable compression spring extending between the outer collar and the sleeve biases the sleeve in a distal direction and also biases the outer collar in rotation relative to the sleeve.

Abstract: An infusion fluid warmer including a heat exchanger and first and second printed circuit boards having respective integrally formed electrically resistive patterns acting as heating elements. The integrally formed electrically resistive patterns are heated by supply of electrical power and thermally coupled to a heat exchanger to warm an infusion fluid flowing through a fluid passage of the heat exchanger.

Abstract: A closure assembly for a medical device including an administering device such as, but not limited to, a prefilled syringe, includes a housing having an access opening, a stop member disposed therein and an end cap. A tip cap, attachable in a flow restricting relation to the medical device is disposed within the housing and is removably connected to a base, wherein the stop member restricts removal of the flow restrictor from the housing through the access opening. The base is disposed in a captured orientation between the stop member and the end cap. The flow restrictor is disconnected from the base when a predetermined force is applied to flow restrictor, as the housing is rotationally attached to the medical device. The flow restrictor remains attached in flow restricting relation to the medical device while being disconnected from the base until the housing is detached from the medical device.

Abstract: A nasal bulb aspirator that can be sized to fit the needs of infants through adults and is designed to ensure that the tip remains hygienically intact by a one-way valve and a counterbalance system that prevents the tip from touching surrounding surfaces, thereby limiting cross contamination from possibly resistant pathogens.

Abstract: An aerosol generator is positioned adjacent to a patient as an attachment to a trocar. The trocar has an entry port for insufflation gas. Aerosol generated by a vibrating element is entrained in the insufflation gas and the mixture is delivered through the trocar. The aerosol may contain a medicament. The trocar may be a conventional trocar. Such trocars are typically used for a camera. The delivery of the aerosolized medicament can occur at the start of the procedure and be delivered in bolus. At the start of the procedure, the peritoneum is being inflated by means of the flow of insufflator gas. This gas flow will help to entrain the aerosolized medicament to the pneumoperitoneum regions. The surgeon can temporarily remove the camera from the trocar port to facilitate insertion and positioning of the aerosolizing unit.

Abstract: An inhaler including a magazine having capsules, a mouthpiece and a cover associated with the mouthpiece, where the cover is radially movable and pivotable for open or closing of the mouthpiece, by pivoting the cover the magazine is conveyed from one capsule to the next capsule, and by radial movement of the cover a capsule is moved in a radial direction into a discharge position.

Abstract: An aerosol-generating system is provided, including a first container including at least one aerosol-generating substrate; a rupturing system including a first tube and a second tube, the first and second tubes being arranged in operational engagement defining a volume, wherein the first and second tubes are movable relative to each other along a first motion path from a first position to a second position, such that the defined volume is larger in the first position than in the second position, wherein the first tube includes a first rupturing member disposed at least partially inside the first tube, such that in the first position, the first rupturing member is contained completely in the defined volume of the first and second tubes, and wherein in the second position, the first rupturing member at least partially protrudes from the defined volume to rupture the container including said substrate.

Abstract: An inflatable balloon cuff may be adapted to seal a patient's trachea when associated with an endotracheal tube. Configurations of these cuffs that include tapered regions with certain characteristics, such as cuff wall diameter and thickness, may provide improved sealing of the trachea.

Abstract: A patient-contacting element for a patient interface for delivering a flow of gas to a user is being configured to provide a substantially air-tight seal with the user's skin during use. The patient-contacting element includes an inlet for receiving at least part of the flow of gas, at least one gas-permeable element that is disposed within the patient-contacting element and arranged in fluidic communication with the inlet, and a first layer of an air-tight material that is arranged between the at least one gas-permeable element and an inner space of the patient-contacting element for receiving a nose and/or a mouth of the user. The air-tight material has at least one opening therein.

Abstract: An endobronchial tube comprising at least two lumens of different lengths for selectively associating with a patient about at least two locations relative to the Tracheal Carina.

Abstract: The present disclosure relates to a device for holding an endotracheal tube. The device includes a rail having opposite ends and a plurality of grooves at least partially along the length of the rail between the opposite ends. The device also includes a tube holder coupled to and slidable relative to the rail between the opposite ends. The tube holder includes at least one lever arm partially received with the grooves of the rail to allow lateral repositioning of the tube holder relative to the rail, a tie having a slit and a plurality of teeth, a base extending away from a patient relative to the at least one lever arm, and a tab extending laterally from the tube holder with the tab configured to be received within the slit of the tie. The base includes a pawl configured to engage at least one of teeth of the tie.

Abstract: A patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to the patient's airways including at least entrance of a patient's nares to ameliorate sleep disordered breathing may include a seal-forming structure comprising a foam undercushion and a textile membrane for contact with the patient's face; a positioning and stabilising structure to maintain the seal-forming structure in sealing contact with an area surrounding an entrance to the patient's airways while maintaining a therapeutic pressure at the entrance to the patient's airways; and a plenum chamber pressurised at a pressure above ambient pressure in use.

Abstract: A portable retractable oxygen tubing reel providing improved portability and mechanical reeling functionality. The portable retractable oxygen tubing reel includes tubing wrapped around an inner circular component stored within an outer storage compartment whereby a handle attached to the inner circular component may be rotated to wind or unwind tubing from the portable retractable oxygen tubing reel. Tubing may then be connected to a medical oxygen storage device at one end and a nasal oxygen cannula positioned near in proximity to a patient's nose for breathing oxygen at the other end.

Abstract: Apparatus (10,226,326) for condensing water from respiratory gases, comprising a heat exchange component (20,234,334) having an inlet (22,228,328), an outlet (24,228,230) and a condensation chamber, the inlet and outlet (22,24,228,230,328,330) being connectable to a breathing system, such that respiratory gases are conveyed through the condensation chamber, in use, and a base unit (30,232,332) adapted to aid removal of heat from the walls of the heat exchange component (20,234,334), wherein the heat exchange component (20,234,334) is releasably engageable with the base unit (30,232,332), such that the heat exchange component (20,234,334) is replaceable.

Abstract: A sleep apnea device with bleed for exhaling including a peripheral wall formed with an interior through passage formed with a proximally facing seat, bleed passages in the wall bypassing the seat and a ball to close against the seat.

Abstract: A purpose is to enable partial replacement of an indwelling urethral catheter. A unit for a balloon catheter according to the present invention includes a urethral catheter tube (13) provided with a first urethral catheterization passage (14), a branch tube (11) provided with a first passage (12) adapted to allow passage of a liquid used to inflate or deflate a balloon (54), and a connecting tube (30) configured to be connected at one end to the first urethral catheterization passage (14) or the first passage (12).

Abstract: A catheter that prevents excessive concentration of stress while providing sufficient flexibility to a distal end portion of the catheter, even when the catheter is inserted and curved in patient's a blood vessel. Thus, breakage of the catheter at a radiopaque marker is prevented/reduced. The catheter includes a catheter tube and the radiopaque marker, which is disposed in the catheter tube. The radiopaque marker is fixed in the catheter so that a gap is provided between the radiopaque marker and the catheter tube in a radial direction of the catheter tube.

Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.

Abstract: The present disclosure provides an access system having a maneuverable catheter assembly configured for providing access to and navigating a desired vessel for subsequent treatment thereof. The access system includes an adjustable delivery handle assembly and an access catheter subassembly having a maneuverable access catheter configured to be delivered to desired site (e.g., within duodenum) to assist in treatment of a condition (e.g., drainage of a bile ducts via Endoscopic Ultrasound Guided Biliary Drainage (EUS-BD) techniques). The access catheter includes at least a distal section having an adjustable portion along a length thereof configured to transition to a pre-defined arcuate shape to provide directional control over the distal end of the catheter as it is navigated through a vessel (e.g., bile duct). The handle assembly includes additional elements configured to allow a clinician to maneuver and manipulate the distal end of the access catheter.

Abstract: A clip for attaching a flexible cable or tube to clothing. The clip comprises a body and a clasp for attaching the body of the clip to clothing. The body comprises at least one receiving formation in the form of a resiliently deformable channel for receiving a flexible cable or tube.

Abstract: A stent delivery method includes: forming through-holes in an alimentary canal wall and a cyst wall so as to communicate with each other; passing a stent through the through-holes and placing a first expandable part in the alimentary canal and a second expandable part in the cyst; allowing the first expandable part to expand to an expanded state in the alimentary canal; and, after the expansion of the first expandable part, allowing the second expandable part to expand in the cyst while the alimentary canal wall is pressed by the first expandable part in the expanded state.

Abstract: A method for using a universal electronic toolset for indicating and adjusting of an implantable programmable bodily fluid drainage valve regardless of whether the valve includes a fixed reference magnet used to determine an angle of orientation of the implantable programmable bodily fluid drainage valve or not. A magnetic field detection sensor array in an indicator tool of the electronic toolset determines whether the fixed reference magnet is present in the implantable programmable bodily fluid drainage valve. If the presence of the fixed reference magnet is detected then the center and direction of flow of the adjustable valve unit is ascertained via electronic feedback from the electronic toolset; otherwise, the center and direction flow is ascertained via exclusively by manual physical palpation of the valve.

Abstract: An injection includes a tube having opposite first and second ends. A hub is coupled to the first end. A sheath is coupled to the tube and the hub. The hub is movable relative to the tube to move the sheath between a first orientation in which the sheath covers an orifice in the second end and a second orientation in which the sheath is spaced apart from the orifice. Kits and methods of use are disclosed.

Abstract: An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a valve including a valve housing and a valve structure located within the valve housing. The valve structure can be configured to permit fluid to flow through the valve when in an open position, and can include a gravity wall wherein, when the valve structure is in the open position, fluid moving through the valve structure moves upward against a force of gravity when travelling through the valve and traversing the gravity wall.

Abstract: Implant tools and techniques for implanting implantable medical leads or other implantable components in extracardiovascular locations, such as substernal locations, are described. In one example, the present application provides an implant tool for implanting a medical lead comprises a handle and a shaft. The shaft includes a proximal segment that is permanently coupled to the handle and a distal segment that is detachably coupled to the proximal segment. The distal segment includes a proximal end configured to couple to the proximal segment, a distal end, and a lumen extending an entire length of the distal segment from the proximal end to the distal end. In some instances, the implant tool may be part of a delivery system that includes a puncturing tool having a proximal end and a distal end, wherein the distal end is sharp, such as a syringe coupled to a needle.

Abstract: A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.

Abstract: Tools adapted to allow a fixation device to be applied near the distal end of an implantable lead, and methods for using such tools. Preparing the lead for implantation may be performed by placing a tool over a distal tip of the lead, moving a fixation device from the tool to the lead, and placing the fixation device the lead.

Abstract: Apparatus and methodologies for the mitigation and prevention of venous thromboembolism-related disorders resulting from by venous blood stasis. More specifically, repeated cycles of brief bouts of intermittent electrical stimulation are repeated every several minutes to contract at least one target muscle, causing a temporary increase in venous blood flow and blood velocity in the veins in the region of the target muscle(s). The present intermittent electrical stimulation paradigm may be used to mimic physiological responses following voluntary contraction of the target muscle(s), without fatiguing the muscle(s).

Abstract: A neuronal tissue-machine interface apparatus includes an array of magnetically-responsive switches positioned in close proximity or contact to neuronal tissue of a human subject, wherein a magnetic environment of the plurality of magnetically-responsive switches varies along the array, and an antenna that is electrically connected to the array, wherein a subset of the magnetically-responsive switches respond to electromagnetic energy received by the antenna, and wherein the response of the subset of the magnetically-responsive switches includes modulation of an electrical current conducted by the subset of the magnetically-responsive switches.

Abstract: A system for an neurostimulator coupled to electrodes. The system comprises a input device configured for generating directional control signals, and memory storing ideal multipole configurations.

Abstract: An implantable cardiac stimulation device provides electrical stimulation therapy to stabilize the ventricular rate of a heart during episodes of atrial fibrillation. The stimulation therapy may be a plurality of sub-threshold stimulation pulses delivered to capture AV node vagal innervations following the detection of atrial fibrillation.

Abstract: An interrogation system for a medical device includes a memory storing a diagnostic algorithm, a processor configured to run the diagnostic algorithm, and a communication module configured to facilitate data transfer between the interrogation system and the medical device. The diagnostic algorithm is configured to reach a diagnostic conclusion based on data from the medical device. The diagnostic algorithm is configured to iteratively interrogate the medical device for the data from the medical device until the diagnostic algorithm reaches the diagnostic conclusion, each iterative interrogation requesting additional data as compared to prior iterations. The communication module is configured to receive the additional data from the medical device in response to each iterative interrogation. The diagnostic algorithm is further configured to store an indication of the diagnostic conclusion within the memory.

Abstract: Far field telemetry operations are conducted between an external device and an implantable medical device while power is being transferred to the implantable medical device for purposes of recharging a battery of the implantable medical device. The far field operations may include exchanging recharge information that has been collected by the implantable medical device which allows the external device to exercise control over the recharge process. The far field operations may include suspending far field telemetry communications for periods of time while power continues to be transferred where suspending far field telemetry communications may include powering down far field telemetry communication circuits of the implantable medical device for periods of time which may conserve energy. The far field operations may further include transferring programming instructions to the implantable medical device.

Abstract: A filtering algorithm implemented by a filtering module in an implantable medical device (IMD), or in an external device for communicating with an IMD, is disclosed which reviews blocks based on a number of rules. The filtering module preferably comprises both firewall and instruction analysis modules. The instruction analysis module analyzes the instructions and associated data (if present) in each block to determine whether such blocks would compromise operation of the IPG or injure a patient if executed. Instruction rules corresponding to an instruction identified in the block are retrieved by the instruction analysis module. The instruction analysis module reviews the block per the retrieved rules, and possibly also in light of current and historical IPG therapy setting or mode data, or other received but un-executed blocks. If a block is compliant, it is executed by the IMD or transmitted to the IMD.

Abstract: An electronic medical monitoring and treatment apparatus allows a victim of a medical emergency person access to a medical professional (MP) who can monitor, diagnose and treat the person from a remote site. The apparatus includes a cardiac medical monitoring and treatment device (MMTD) coupled to an electronic adapter designed to communicate with a local, first transmitting/receiving (T/R) device which, in turn, is adapted to electronically communicate with a remote, second transmitting/receiving (T/R) device used by the MP. The MMTD may comprise a cardiac treatment circuit for effecting cardiac pacing and/or defibrillation and a cardiac signal circuit for receiving cardiac signals. The cardiac signals are (1) transmitted from the signal circuit to the second T/R device for evaluation by the MP, (2) the MP may transmit a control signal to the treatment circuit, and (3), in response thereto, the treatment circuit may generate one or more electrical pulses for treatment of the person.

Abstract: An external charging system for an Implantable Medical Device (IMD) is disclosed having a thermal diffuser proximate to the primary charging coil for distributing heat from the primary charging coil. In an example, the primary charging coil is mounted to a first side of a circuit board, and the thermal diffuser is also connected to the first side and in contact with the primary charging coil. In one example, the thermal diffuser is a plastic material, such as an acrylic pad, with a high thermal conductivity and a low electrical conductivity. The thermal diffuser may also contact temperature sensors mounted to the first side of the circuit board.

Abstract: A system, device and method are provided for exposing a patient to therapeutic resonant frequency patterns (RFP) for therapy and treatment of a patient, for example, biological tissue such as muscle, tendon, ligament, and nerve tissue. The resonance frequencies originate from many bioactive substances, pharmaceuticals or other compounds, and key frequencies of the RFP of a compound can be replicated and then delivered to a patient using an electromagnetic catalyst to provide therapeutic benefits. RFPs can be imprinted in a separate device using a plasma imprinting device and method. This separate device can be actively excited by a delivery mechanism that uses electromagnetic or mechanical waves to interact with the device. The actively excited device transmits the RFPs or therapeutic resonant frequency patterns to the patient for similar enhancements and therapeutic benefits.

Abstract: A phototherapy device for promoting wound healing and treating pain associated with soft-tissue and musculo-skeletal injuries is presented. The phototherapy device may deliver therapeutic light outputs that are variable, in real time, based in part on morphologic data of the patient measured by the device in real-time.

Abstract: A medical apparatus and method of operating a medical apparatus are disclosed. The apparatus includes a radiation source for emitting electromagnetic radiation towards one or both eyes of a patient; wherein the apparatus is configured to emit electromagnetic radiation having a ratio of scotopic luminous intensity to photopic luminous intensity of at least 1.85:1.

Abstract: A transparent loading apparatus (also referred to herein as a “loader”) may partially or entirely comprise transparent material that allows light to pass through the loader and provides the viewer (whether manual or automated) a view of a radioactive seed, a seed carrier, a loading needle, etc. within the loader. In some embodiments, carrier material (e.g., collagen and/or other biocompatible material) and radioactive seeds (e.g., including a metal shielding and radioactive isotope) may transmit light to different degrees. For example, certain carriers, such as collagen carriers, may be translucent, while seeds may be opaque (or mostly opaque) to light. The systems discussed herein allow a viewer to detect location of a seed within a loader, and even within a carrier, because of these different light transmissivity characteristics.

Abstract: In the field of radiotherapy, methods for dose or treatment planning for a radiotherapy system are disclosed, wherein a spatial dose delivered can be adjusted and delivered radiation is determined using an optimization problem that steers the delivered radiation according to a frame description reflecting criteria for regions of interest that include at least one of targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes estimating a voxel set receiving a higher dose than a predetermined threshold dose level, which voxel set includes voxels from at least one target volume. Further, a low dose voxel set is determined and a frame description for the voxels in the low dose voxel set is provided where voxels receiving a dose exceeding a predetermined threshold value is penalized such that the dose delivered to the low dose voxel set is suppressed. The frame description is then used in the optimization problem that steers the delivered radiation.

Abstract: An optimization method for a radiotherapy plan using robust optimization to handle different scenarios that may occur during one treatment session because of patient movement. The optimization is based on the period and amplitude of the movement, the starting point of the treatment session within a period and the delivery time structure.

Abstract: A multileaf collimator includes a plurality of beam-blocking leaves of a first type and a plurality of beam-blocking leaves of a second type. The beam-blocking leaves of the first type are alternatingly arranged with the beam-blocking leaves of the second type side by side. Each of the beam-blocking leaves of the first type has a trapezoidal geometry viewed in the leaf longitudinal moving direction comprising a wider end and a narrower end with the wider end being proximal to a source. Each of the beam-blocking leaves of the second type has a trapezoidal geometry viewed in the leaf longitudinal moving direction comprising a wider end and a narrower end with the wider end being distal to the source.

Abstract: Magnetic resonance (MR) guided radiation therapy (MRgRT) enables control over the delivery of radiation based on patient motion indicated by MR imaging (MRI) images captured during radiation delivery. A method for MRgRT includes: simultaneously using one or more radiation therapy heads to deliver radiation and an MRI system to perform MRI; using a processor to determine whether one or more gates are triggered based on at least a portion of MRI images captured during the delivery of radiation; and in response to determining that one or more gates are triggered based on at least a portion of the MRI images captured during the delivery of radiation, suspending the delivery of radiation.