Abstract: Described herein is a respiratory therapy system comprising: a primary power supply, a secondary power supply, and a breathing apparatus configured to provide respiratory therapy. The breathing apparatus comprises a controller. There is a connection between the primary power supply and the breathing apparatus configured to facilitate transmission of power and data between the primary power supply and the breathing apparatus. The controller is configured to monitor a parameter of the primary power supply, and disengage the primary power supply if the parameter differs from a parameter threshold. The controller is configured to engage the secondary power supply on disconnection of the primary power supply such that the breathing apparatus can continue operation without interruption.

Abstract: An automatic ventilator adjusting system has a three-way inline adapter coupled to 1) a breath sample line, 2) a ventilator (either invasive or non-invasive), and 3) a patient. The breath sample line is coupled to a Gas Exchange Monitor (GEM) and preferably has a female Luer lock end. Ventilator settings can be automatically set and/or adjusted using 1) an algorithm preferably having a feedback loop and 2) inputs including one or more of: gPaO2™ (calculated arterial partial pressure of O2 by GEM), oxygen deficit, gPaCO2™ (calculated arterial partial pressure of CO2), gPaCO2™/gPaO2™, PiO2-PETO2, TLC (Total Lung Capacity), FRC (Functional Residual Capacity), and Vd/Vt (deadspace ratio). Preferably, one or more of the inputs (e.g., gPaO2™ gPaCO2™, and oxygen deficit) are obtained non-invasively from a patient's normal breathing gas samples as calculated by MediPines Gas Exchange Monitor (GEM).

Abstract: An endotracheal tube to bag valve device connecting assembly for quick access to an endotracheal tube for suctioning includes a first tube and a second tube that are coupled to a hinge so that the first tube is positioned to be swiveled relative to the second tube to align the first tube with the second tube, wherein the first tube and the second tube define a pipe. A first end of the pipe is configured to selectively couple to a patient valve of a bag valve device. A second end of the pipe is configured to selectively couple to an endotracheal tube. The pipe is configured to allow flow of gas from the bag valve device to the endotracheal tube. The first tube is positioned to be swiveled on the hinge so that the second tube is configured to insert a suction tube into the endotracheal tube to clear an airway.

Abstract: An endotracheal tube holder device is provided for securely holding an endotracheal tube to a patient during intubation. The tube holder device includes a support rail placed above a lip of a patient. An auxiliary clip is coupled to the support rail and slidably movable along the length of the support rail for holding an accessory device relative to the patients face. The auxiliary clip includes both a horizontal accessory clip and a vertical accessory clip to releasably retain the accessory device horizontally and vertically, respectively. A tube fastener is coupled to the support rail and includes a tube holder base, an adjustment clip coupled to the tube bolder base for laterally repositioning the tube holder base along the support rail, and a securement tie. The securement tie may be wrapped around a portion of the endotracheal tube to secure the tube to the tube holder base.

Abstract: A respiratory mask system is provided comprising a respiratory mask and a head engaging portion, wherein the head engaging portion is configured to couple to the respiratory mask to engage a wearer's head via a disengageable mechanism. The dis-engageable mechanism may comprise a linking member attached to the head engaging portion, a disengagement member attached to the respiratory mask and configured to receive the linking member, wherein the disengagement member is configured to be moveable between a first position and a second position, a control configured to allow a wearer of the mask to move the disengagement member towards the first position and one or more surfaces defined by the disengagement member and configured to exert a frictional force on the linking member.

Abstract: A breathing arrangement includes a patient interface, at least one inlet conduit, and a headgear assembly. The patient interface includes a mouth covering assembly including a cushion structured to sealingly engage around exterior of a patient's mouth in use, a nozzle assembly including a pair of nozzles structured to sealingly engage within nasal passages of a patient's nose in use, and a flexible element connecting the mouth covering assembly and the nozzle assembly. The at least one inlet conduit is structured to deliver breathable gas into at least one of the mouth covering assembly and the nozzle assembly for breathing by the patient. The headgear assembly is removably connected to at least one of the mouth covering assembly and the nozzle assembly so as to maintain the mouth covering assembly and the nozzle assembly in a desired position on the patient's face.

Abstract: Nasal respiratory assembly comprises a pair of sheets. Each sheet defines an opening sized and shaped to fit over the nostril of a patient, with a ferromagnetic ring positioned at an underside of the sheet, with an upper side of the sheet configured for sealable engagement with the nostril. A pair of posts is provided, each post including a magnetic ring positioned at a first end and a receptacle positioned at a second end, the magnetic ring removably attachable to the ferromagnetic ring. A connector is also provided, the connector including a pair of channel openings at a post end, each channel opening sized and shaped to cooperate with one of the post receptacles to form a substantially airtight connection therewith, and an inlet at a vent end that is fluid communication with a flexible tubing connected to a fluid source.

Abstract: In one embodiment, a nasal cannula is shaped to fit within a user's nares, where the nasal cannula includes at least one prong allowing high flow delivery of humidified gases and creates positive airway pressure in the patient's airway. The prongs have angled ends such that, in use, gases flowing through the prongs are directed to the user's nasal passages. The nasal cannula body is partially swivelling and preferably has a ball joint connector. In another embodiment the nasal cannula may have at least one flared end prong that preferably seals within a patient's nare.

Abstract: A method of manufacturing a patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to the patient's airways includes collecting anthropometric data of a patient's face. Anticipated considerations are identified from the collected anthropometric data during use of the patient interface. The collected anthropometric data is processed to provide a transformed data set based on the anticipated considerations, the transformed data set corresponding to at least one customised patient interface component. At least one patient interface component is modeled based on the transformed data set.

Abstract: An oral capnography accessory device provides a pathway for sampling oral exhalations of carbon dioxide from a mouth of a patient. The device is used in combination with a bite block. The device includes a main body extending linearly along a longitudinal axis, latch arms extending from a buccal facing surface of the main body and forming a cavity into which the bite block is insertable, and tube attachment extending from a lingual facing surface of the main body. Tubing is insertable through a passageway therethrough of the tube attachment. The device is configured for use with a nose or face mask, and with a monitoring system.

Abstract: The invention allows for considerably improving the efficiency of inhalation treatment of various diseases and conditions in pulmonology, therapy, intensive treatment, anesthesiology, and sports medicine and is provided with new integral technical solutions while employing the opportunities of microelectronic technology and modern components. A modular structure of the apparatus simplifies its manufacture, ensures the ease of setting it up, and operation in various operating modes. When using the invention, monitoring of the ventilation indicators and patient condition with achieving his high safety level may be ensured; in sports medicine a problem of rehabilitation and training of athletes with the background of extreme loads and increased ventilation indicators is solved.

Abstract: A CPAP device includes a flow generator including an outlet, a humidifier including an inlet, and an adaptor connector between the outlet of the flow generator and the inlet of the humidifier. The connector includes a flexible and conformable sealing portion that is movable to accommodate misalignment.

Abstract: A humidifier for humidifying a flow of air to be delivered to a patient includes a base unit having at least one wall defining a receiving space. The base unit also includes a variable volume reservoir configured to hold a body of water and receive the flow of air to humidify the flow of air for delivery to the patient. The receiving space is configured to receive the variable volume reservoir and the variable volume reservoir is conformable to a shape of the receiving space. The humidifier further includes a heater for heating the body of water.

Abstract: In one embodiment, there is provided a humidification chamber for use in a medical humidification system. The humidification chamber may comprise: a base and a top linked by a side wall to define the chamber, the chamber being configured to contain a volume of water; a gases inlet configured to receive a gases flow from a gases source; and a gases outlet, wherein the gases inlet is orientated relative to the side wall to introduce the gases flow to the humidification chamber at a direction substantially tangential to the side wall of the humidification chamber.

Abstract: Systems and methods are provided for delivering anesthetic agent to a patient. In one embodiment, an anesthetic vaporizer includes a vaporizing chamber configured to hold a liquid anesthetic agent, and an inductive heating element positioned exterior to the vaporizing chamber and housed within a gas-tight barrier, the inductive heating element operated to selectively heat a target.

Abstract: Systems and methods are provided for delivering anesthetic agent to a patient. In one embodiment, an anesthetic vaporizer includes a housing defining a sump, the sump configured to hold a self-contained supply of liquid anesthetic agent, a heating element electrically coupled to an electrical mating component, a gas inlet passage and a gas outlet passage, a manifold fluidically coupled to the gas inlet passage and the gas outlet passage, the manifold coupled to the housing and forming a gas-tight seal with the sump, and a quick disconnect pneumatic system coupled to the gas inlet passage and the gas outlet passage, sealing the gas inlet passage and the gas outlet passage from atmosphere.

Abstract: An improved hiatal hernia treatment enhances recovery after surgery by reducing a patient's pain at an area of treatment. The area of treatment contains a hiatal hernia and must be extensively divided before the hiatal hernia can be treated. The improved hiatal hernia treatment reduces pain through directed application of anesthetic via an applicator positioned within the area of treatment. Reduction of pain increases patient comfort reduces the need for pain medication, and lowers patient blood pressure to enhance recovery.

Abstract: The present invention relates to a device for providing an intervention for users who suffer from sleep paralysis. More specifically, the present invention illustrates a wearable device that measures the user's heart rate while they sleep. If the heart rate rises above a pre-set threshold level, then the device activates an element that exerts an external stimulus on the user causing the user to wake or providing a focal point for the user to overcome the sleep paralysis.

Abstract: One aspect of the invention provides a system for virtual reality (VR) behavior modification. The system includes a VR headset adapted or configured to generate a VR environment comprising at least one VR object corresponding to a behavioral condition of a user; display the VR environment to the user; receive a response from the user comprising an interaction of the user with the at least one VR object; determine a behavioral modification score for the user based on the received response; and alter the at least one VR object based on the received response and the determined behavioral modification score.

Abstract: A relaxation mask includes: a main body that defines a pair of eye cavities; wiring; an earpiece that is coupled to the main body via the wiring; and a spring configured to bias the earpiece towards the main body.

Abstract: A relaxation mask includes: a main body that defines a pair of eye cavities; and a light diffuser. The light diffuser includes a first lens that is disposed within a first one of the eye cavities. A first ledge is disposed along a top edge of the first lens and extends outwardly therefrom. A first light emitting component is supported on the first ledge and is configured to fire downward into the first lens.

Abstract: A sleep intervention equipment, system and method are provided. The sleep intervention equipment includes a physical sign detection device, a first processor, and a sleep intervention device. The first processor is communicatively connected to the physical sign detection device and the sleep intervention device, respectively. The physical sign detection device is configured to detect a user's physical information without touching the user, and send the physical information to the first processor. The first processor is configured to determine a sleep stage and/or breath state of the user according to the physical information, and send a corresponding control instruction to the sleep intervention device according to the sleep stage and/or breath state of the user. The sleep intervention device is configured to perform a corresponding sleep intervention behavior in response to the control instruction. The sleep stage includes a waking state, an approaching waking state, or a sleep state.

Abstract: An eyeshade and an electroencephalogram detection system are provided. The eyeshade includes an eyeshade main body; and an electroencephalogram acquisition unit, a controller and a heating unit which are disposed on the eyeshade main body. The electroencephalogram acquisition unit is configured to acquire a brain electrical signal of a wearer. The controller includes a converter and is configured to receive the brain electrical signal from the electroencephalogram acquisition unit, the converter is detachably coupled to the electroencephalogram acquisition unit and is configured to convert the brain electrical signal into a communication signal and transmit the communication signal to outside when coupled to the electroencephalogram acquisition unit. The heating unit is configured to heat an eye region of the wearer.

Abstract: Non-pharmaceutical systems and methods of treating the symptoms of fibromyalgia are described. The method includes administering a therapeutically effective amount of a sensory stimulus to a person, wherein the sensory stimulus includes one or more visual stimuli and one or more auditory stimuli.

Abstract: A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat at least one of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).

Abstract: A pistoning prevention system (PPS) that will improve catheter associated urinary tract infection rates of an indwelling Foley catheter while maintaining reliability, comfort, & safety. With the PPS incorporated within a Foley catheter during manufacturing it will eliminate the excess stretch along a specific length of a Foley catheter that resides within the patient's urethra. The excessive amount and ease of stretch is responsible for the pistoning action of an indwelling Foley catheter moving in and out of the urethra. This action is responsible for the retrograde movement of bacteria outside the body & into the urethra, bladder, & kidneys increasing preventable infections. With much prevention work globally, the pistoning action of a Foley catheter is now known to be partially or wholly to blame for the attributed $340 million spent in the U.S. on healthcare costs & 13,000 associated deaths making this an immediate global patient safety emergency.

Abstract: Medical devices and instruments, particularly pericardial access systems and devices and related methods are disclosed. Some example pericardial access devices may include a distally located, expandable skirt configured to engage the pericardium. When extended, the skirt may be wider than the tubular body of the device. Some example pericardial access devices may include an at least partially transparent, repositionable tip.

Abstract: A medical device including a handle body having a proximal end and a distal end, a spool on the handle body and to move between the distal end and the proximal end of the handle body, a catheter extending from the distal end of the handle body, an actuator attached to the spool and extending through the catheter, such that the actuator is removably connected to one or more dispensable devices at a distal end of the catheter, a spool controller to prevent connection with another of the dispensable devices to the actuator after a predetermined number of dispensable devices have been dispensed by the medical device.

Abstract: A catheter delivery system (10) includes: (i) an introducer sheath (12); (ii) a catheter (14) disposed at least partially within the introducer sheath and movable axial along the introducer sheath; (iii) an invaginating tube (16) sealably secured at or near a first axial end (16a) of the invaginating tube to the introducer sheath at or near a first axial end (12 a) of the introducer sheath; (iv) a runner (28) slidably connected to the catheter; (v) the invaginating tube being sealably secured at or near a second axial end (16b) of the invaginating tube to the runner, such that the runner with inavaginating tube secured thereto is sealably connected to the catheter and movable axially along at least a portion of the catheter; and (vi) means for pressurising the annular space defined between the introducer sheath, the catheter and the invaginating tube.

Abstract: Certain aspects relate to a handle mechanism that permits control of linear motion of a shaft secured within the handle via two different interfaces for actuating the linear motion. In some aspects, a rotational interface can allow for fine control linear positioning of the shaft, for example by allowing a user to rotate the rotational interface to extend or retract the shaft. In some aspects, a plunging interface can enable a faster linear motion, for example by implementing a biasing mechanism that releases to drive rapid linear motion.

Abstract: Guide extension catheters and related methods are disclosed. A guide extension catheter can comprise an elongate tube member, a push member, and an external manipulation member. The push member can be eccentrically coupled relative to the tube member and extend proximally therefrom for slidably positioning the tube member within and partially beyond a distal end of a guide catheter. The manipulation member can be coupled to a proximal end of the push member, where the manipulation member can be configured to secure the guide extension catheter in place during use by attaching to an external object such that the tube member and push member remain stationary without user engagement.

Abstract: Guide extension catheters and related methods are disclosed. A guide extension catheter can comprise an elongate tube member, a push member, and a removable support member. The push member can be eccentrically coupled directly or indirectly to the elongate tube member and can extend proximally therefrom for slidably positioning the elongate tube member within and partially beyond a distal end of a guide catheter. The removable support member can comprise a structure that surrounds at least a portion of the push member.

Abstract: A bendable sheath and a delivery system using the bendable sheath. The bendable sheath comprises a tube body (3). The tube body (3) comprises a distal end and a proximal end. A tube wall of the tube body (3) is connected to a pull wire (8). One end of the pull wire (8) extends towards the proximal end of the tube body (3), and the other end is connected to the tube body (3) near the distal end of the tube body (3). The pull wire (8) comprises at least a section thereof disposed freely outside the tube body (3) and near the distal end of the tube body (3). The pull wire (8) in the bendable sheath comprises the section disposed freely outside the sheath tube body (3) and, when pulled, the section is disposed so as to facilitate the application of force. The section moves relative to the tube body (3), such that a force application point is adaptively changed.

Abstract: A flexible guide tube having a deflectable distal end is disclosed with at least first and second tensioning lines coupled to a deflectable distal end of the flexible guide tube. The first tensioning line is configured to deflect the distal end of the flexible guide tube in a first direction and the second tensioning line is configured to deflect the distal end of the flexible guide tube in a second direction that is opposite the first direction. A handle is coupled to flexible tube, the handle having a medial portion with a longitudinal axis substantially parallel with at least a portion of the flexible guide tube, a first actuator disposed proximal the medial section, and a second actuator disposed distal the medial section.

Abstract: A medical tube holder is proposed. The medical tube holder includes: holder bodies and surrounding an outer surface of a medical tube; and fluid pockets provided in the holder bodies to form a predetermined space and discharge fluid stored therein to the outer surface of the medical tube while at least a part of the fluid pockets is broken when pressed by an external force. The fluid pockets are formed in the medical tube holder, and when the fluid pockets are pressed by the external force, the fluid pockets are broken and a fluid (i.e., a lubricant) stored therein is discharged to an outer surface of the medical tube. Accordingly, a user may easily apply the fluid such as the lubricant by using the medical tube holder.

Abstract: A catheter assembly with segmented or step-wise deployment stabilization system includes a base or handle, puncture needle extending from the handle, and a deployment mechanism or mechanisms to selectively extend from the distal end of the needle for first length a hollow stabilizing component and as a second step to a second further length a stabilizing guide wire element. The hollow stabilizing component has some degree of flexibility as does the guide wire to minimize chance of damage to surrounding tissue. The user can feel resistance and have the opportunity to retract either component and attempt redeployment without a retraction of the puncture needle and a second poke of the patient's skin. In the example for peripheral venous catheterization, the system reduces the probability of blood vessel puncture. The deployment mechanism can have a guiding system which ensures the proper sequence of deployment.

Abstract: A catheter assembly including a catheter carried by a catheter adapter, a needle having a sharp distal tip and disposed in the catheter such that in a first needle position, the needle extending beyond the catheter, a septum actuator having openings, the septum actuator disposed in the catheter adapter and configured to pierce a septum, and a spring clip disposed in the septum actuator and engaging the openings of the septum actuator in the first needle position.

Abstract: A catheter system may include a needle assembly coupled to a catheter adapter. The needle assembly may include a housing, an introducer needle, a distal opening, a first magnet, and a second magnet. In response to proximal withdrawal of the introducer needle, the first magnet may move towards the second magnet, which may block the distal opening and/or prevent blood from leaking out the distal opening.

Abstract: A catheter system may include a needle assembly coupled to a catheter adapter. The needle assembly may include a housing, an introducer needle, a proximal opening, a distal opening, and a needle tip shield feature. A distal tip of the introducer needle may be configured to be proximally withdrawn from a first position to a second position in which a bump feature of the introducer needle contacts and is prevented from moving through the proximal opening. In response to withdrawal of the distal tip proximally from the second position to a third position, the housing may move proximally, and the needle tip shield feature may be released to block the distal opening. The needle tip shield feature may not contact the introducer needle when the distal tip moves proximally from the first position to the second position and from the second position to the third position, which may reduce a friction-based drag force on the introducer needle.

Abstract: The present disclosure relates to vascular devices such as guidewires and microcatheters having integrated coil sections for optimizing torquability, flexibility, and ability to shape and maintain the distal tip. A guidewire device includes a core and a tube structure coupled to the core such that at least a portion of the core passes into the tube structure. A distal section of the tube structure includes a spiral cut arrangement that configures the distal section as an integral coil integrally incorporated as part of the tube structure. The integrated coil configuration increases the flexibility of the tube structure to reduce the tendency of resilient forces from the tube structure to disrupt a shaped distal tip of the guidewire device.

Abstract: A housing has a spiral passageway which contains a catheter which may be manually extracted from the housing by means of a wheel having a polygonal or otherwise textured circumferential surface and mounted on a shaft which extends through a non-circular bearing defined in an outer portion of the housing. An inner portion of the wheel extends into the spiral passageway adjacent the wire catheter and an outer portion of the wheel outwardly from the housing whereby the upper surface of the knob can be manipulated by a member of the surgical team in one direction and the wire catheter below the knob will be advanced in the opposite direction. The non-circular bearing has a generally circular outer portion in which the textured surface of the knob is only intermittently in contact with the catheter whereby the wire catheter may be advanced, and a generally linear inner portion sloping inwardly towards the catheter.

Abstract: This invention is a transvascularly placed steerable guidewire, further including internal steerability and the ability to articulate in a direction at right angles to its longitudinal axis at or near its distal end. The steerable guidewire is generally fabricated from stainless steel and includes an outer tube, an inner tube, hub structures, and a distal articulating region. The steerable guidewire can be advanced through a body lumen in its straight configuration and then be selectively articulated or curved to permit negotiation of tortuous curvature. The steerable guidewire hub can be removed to permit advancement of catheters over its proximal end followed by re-attachment of the hub to permit deflection of the distal end of the steerable guidewire. Removal of the hub can result in a limp guidewire or maintenance of a forced curvature of the distal end of the guidewire.

Abstract: A medical device comprises a catheter having a lumen extending between a distal end and a proximal end of the catheter and a balloon having an expandable interior volume coupled to the distal end of the catheter with its interior volume in fluid communication with the lumen of the catheter. A spring-loadable mechanical structure is disposed within the balloon configured to snap between first and second configurations upon actuation by an actuation mechanism. Upon actuation, the spring-loadable mechanical structure creates pressure pulses in fluid within the balloon interior volume which are transmitted to the walls of the balloon to disrupt calcified material or other hardened material within a vessel of the human or animal body in which the balloon is situated.

Abstract: This patent document discloses guide extension catheters for use with a predefined length guide catheter and related methods for treating blood vessel lesions and abnormalities. A guide extension catheter can include a push member, an elongate tube member, and a balloon radially surrounding a portion of the elongate tube member. The balloon can include an inflatable tube coupled to an elongate shaft having a lumen for receiving inflation fluid, and the inflatable tube can be coiled in a helical manner around the elongate tube member. A bioactive layer can coat an outer surface portion of the balloon and, when the balloon is inflated, one or more drugs of the bioactive layer can be received by the blood vessel. Inflation of the balloon can engage the elongate tube member with an inner surface of the blood vessel and/or an inner surface of the guide catheter.

Abstract: An implantation tool to implant a paranasal sinus fluid access implant device to fluidly connect the lacrimal apparatus in the orbit with a paranasal sinus has a securement mechanism reconfigurable from a securement configuration to secure the implant device to a mounting portion of a carrier member to a released configuration to release the implant device from the carrier member, and with a release mechanism disposed at least partially in an interior working space housed within the implantation tool. An implantation method with an approach through the palpebral fissure advances the implant device through a surgical route mostly under tension.

Abstract: A girth adjustable device for dilation and stretch of body orifices for medical applications, massage, body orifice improvement and activities pleasurable to the body, that can repeatedly, gradually increase and decrease a uniform and sustainable pressure against the entire lateral surface area of body orifices. The girth adjustable device comprises at least one controller, a housing, at least one threaded shaft, at least one module, a plurality of shaft members and at least one sheath. The part of the girth adjustable device that has to be inserted into body orifices is the shaft. In a body orifice, the user increases and decreases the girth size of the shaft via the controller.

Abstract: The invention provides a drug-releasing implant, comprises the implant for fixing the surgical site, said implant is provided with the drug cavity for storing drug, said drug cavity is filled with liquid drug; said implant is further provided with micro pipeline, the micro pipeline passes through the drug cavity and the surface of the implant, the drug in the drug cavity is slowly released to the surgical site through the micro pipeline. The implant can effectively fix the bone at the surgical site (fracture site), after the surgery is completed, the drug set in implant's drug cavity slowly releases to the fracture site through micro pipeline, achieve local application of drug and reduce oral medication, so that decrease the fracture patients' medical expenses and psychological stresses, improve the utility of the device.

Abstract: A 3D printed biocompatible drug delivery device is provided having a fluid delivery channel distinguishing three segments and a receiving chamber with an array of microneedles. The three segments of the delivery channel are stagnation zones before a drug is extruded and whereby an inverted funnel provides an increasing extrusion surface servicing the drug to the array of microneedles. The design of the device with its flow-related components circumvents the challenge of colloidal stability associated with multi-phase formulations leading to nozzle blockage. Qualitative screening cytotoxicity tests pre and post-extrusion through the drug delivery device using mammalian cells rule out cytotoxicity and outline equivalent viability to control treatments. The biocompatibility results suggest that the fluid delivery design, the photoresin selected as well as the fabrication and sterilization may be extended over a range of regenerative medicine and drug delivery applications.

Abstract: The present invention chiefly aims at providing a new patch which is excellent in the fixability to the skin, regarding the patch carrying a microneedle array. The present invention, for example, can include a patch in which a microneedle array is carried on a surface of the pressure-sensitive adhesive layer-side of an adhesive member which is characterized in setting up a pressure-sensitive adhesive on one surface of a support and in having a rigidity of 1.3 MPa·mm4 or more, the adhesive member thereof, and the like. The patch or the like of the present invention is useful for pharmaceuticals and the like because the puncturability of microneedle is improved, and a microneedle array can be firmly fixed to the skin, and drugs can be quantitatively administered without waste.

Abstract: A medical tubing system whereby the tubing is configured to break apart when subjected to forces, thereby reducing the risk of patient strangulation through accidental entanglement or deliberate self-harm attempt.