Patents Issued in January 14, 2021
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Publication number: 20210008512Abstract: A method for enhancing mixing and aeration of a liquid reaction medium in a toroidal bioreactor vessel includes dispensing a liquid reaction medium into an interior of a toroidal bioreactor vessel, the interior being bounded by an inner surface, a textured surface being arranged on at least a portion of the inner surface, the textured surface having a plurality of upstanding protuberances. The toroidal bioreactor vessel is rotated in an orbital motion such that there is a resonant frequency traveling wave of the fluid orbiting in one direction in the interior of the toroidal bioreactor vessel when a particular orbital speed is imparted to the toroidal bioreactor vessel.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Inventors: Mark D. Selker, Barbara Paldus
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Publication number: 20210008513Abstract: This disclosure relates to a magnetic mixing apparatus that mixes a sample contained in a mixing chamber using a stir bar, while minimizing the amount of contact between the stir bar and walls of the mixing chamber. In one aspect, the apparatus comprises a ferromagnetic stir bar contained in the mixing chamber, and a driving magnet and a driven magnet located on opposite sides of the mixing chamber. The driving magnet, the driven magnet, and the ferromagnetic stir bar are each capable of rotating about a respective axis. The driving magnet, the driven magnet, and the ferromagnetic stir bar are magnetically coupled such that rotation of the driving magnet induces rotation of the driven magnet and rotation of the driving magnet and the driven magnet induce rotation of the ferromagnetic stir bar. In some embodiments, rotation of the ferromagnetic stir bar within the mixing chamber mixes the sample contained within the mixing chamber.Type: ApplicationFiled: September 12, 2018Publication date: January 14, 2021Applicant: TALIS BIOMEDICAL CORPORATIONInventors: Thomas H. CAULEY, III, David ROLFE
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Publication number: 20210008514Abstract: A method for providing blended consumer goods to a user by using a blending device (BD) that is adapted to store at least two starting goods blendable into a blended consumer good comprises: recording (REC) selection data concerning selections of the blended consumer goods by the user; recording response data provided by the user concerning responses to the selected blended consumer goods; and processing (COD1-COD5, PP, DA) the data to prioritize presentation (SP, AUI) of blended consumer goods on a user interface (BD, UCD) for selection by the user. A data processing device (DPD, BD, UCD) comprises a data processing unit and a data storage (DB) for storing the recorded data and/or the processed data, wherein the data processing device is adapted to perform the method. A system comprises the data processing device and at least one blending device. The invention is particularly useful for blending fragrances, food, or beverages.Type: ApplicationFiled: November 8, 2018Publication date: January 14, 2021Inventors: Hugo LASALA ALONSO, Alvaro SUAREZ IRIBARNE, Jakub Jan JEDLINSKI, Lucia SCHUSTER
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Publication number: 20210008515Abstract: The invention relates to a fluid mixing device which mixes a base fluid with one or more additive fluids coming from respective containers, said device being characterised in that it is quick and easy to use and in that no traces are left between uses. The device comprises a first module (1) for extracting at least one first fluid contained in at least one base fluid container (23), a drag, extrusion and discharge mechanism (2), a second module (3) for extracting one or more second fluids or additive fluids from one or more additive containers (24), a mixing tank (4) provided with a hole for the discharge of the final mixture, a battery-powered electronic control board (27), wherein a single stepper motor is used for applying pressure to the base fluid container and the additional fluid container(s), and the drag, extrusion and discharge mechanisms (2) are actuated.Type: ApplicationFiled: June 1, 2018Publication date: January 14, 2021Inventors: RUBEN RUBIALES VÁZQUEZ, ALBERTO PORTILLO GONZÁLEZ
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Publication number: 20210008516Abstract: Mixing device having a container rotatable about container axis, with emptying opening being arranged in the bottom thereof, rotatable mixing tool arranged in the interior of the container, and closure element for closing the emptying opening. The closure element can be pivoted about a pivot axis for opening and closing the emptying opening. With the emptying opening closed, the closure element has inner surface arranged within the container, outer surface arranged outside the container, and edge surface arranged opposite an edge surface of the emptying opening. The closure element, emptying opening and pivot axis are of such a configuration and arrangement that a point arranged furthest away from the pivot axis on the inner surface or the edge surface describes a circle in the pivotal movement, wherein the closure element is arranged within the circle and the edge surfaces of the emptying opening are arranged outside the circle.Type: ApplicationFiled: March 8, 2019Publication date: January 14, 2021Applicant: Maschinenfabrik Gustav Eirich GmbH & Co. KGInventors: Timo GÜNTHER, Christian OTT
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Publication number: 20210008517Abstract: A catalytic cracking system in which liquid hydrocarbon and bio-oil are directed into a reactor riser of a fluid catalytic cracking unit by separate feed spray nozzle assemblies. To protect liquid bio-oil directed through the liquid bio-oil feed nozzle assembly from high temperature degradation, an insulating layer is provided between a central bio-oil feed tube in a concentrically surrounding atomizing gas passageway. Cooling channels also may be provided in the spray tip of the bio-oil feed nozzle assembly.Type: ApplicationFiled: July 10, 2020Publication date: January 14, 2021Inventors: Bandish Patel, Digna Boatman, Eusebius Anku Gbordzoe
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Publication number: 20210008518Abstract: Described herein is a process for producing perfume- or flavor-containing microcapsules with improved deposition of encapsulated actives on targeted surfaces such as fiber, hair and skin, which can be used in home or personal care products. Also described herein are microcapsules obtainable by such a process and consumer products including these microcapsules.Type: ApplicationFiled: March 25, 2019Publication date: January 14, 2021Inventors: Lei Shi, Lahoussine Ouali, Lei Han
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Publication number: 20210008519Abstract: The invention relates to a reactor and to a method for continuous polymerization, in which said reactor for the continuous production of polymers, particularly synthetic rubbers, contains at least one substantially tubular reactor housing (4), wherein said reactor housing (4) has a drive shaft (30) that is connected to at least one agitator (38) arranged such that it can rotate inside the reactor housing (4), and the agitator contains at least one, and preferably two, three or four helical mixing elements (24) which are designed to be preferably close to the wall or to come into contact with the wall.Type: ApplicationFiled: July 6, 2018Publication date: January 14, 2021Inventors: Rolf FELLER, Hanns-Ingolf PAUL, Paul WAGNER, Udo WIESNER
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Publication number: 20210008520Abstract: Disclosed is the object of the present invention to provide a far-infrared negative ion carbon composite plate and a manufacturing process thereof. The composite plate comprises the following components (by weight percentage): 10-6000 mesh mica powder 0.5%-95%; 10-200 mesh carbon powder 5%-91%; resin 15%-90%; dispersant 0.1%-10%; zeolite powder 1%-50%; foaming agent 0.1%-20%; and regulator 0.1-20%. The physical properties such as hardness, density, bending strength, and high and low temperature resistance of various plates of the present invention can be adjusted by means of the formulation and temperature of the material; the plates can resist 80% or more of the pressure and wear resistance of ordinary plates, and have a certain cushioning performance. The plates have no bad and harmful substances; far-infrared emissivity of as high as 80% or more, and the amount of negative oxygen ions released of 1000/cc or more.Type: ApplicationFiled: March 15, 2019Publication date: January 14, 2021Inventor: Xingan ZHAO
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Publication number: 20210008521Abstract: Provided is a method of preparing a superabsorbent polymer. More particularly, provided is a method of preparing a superabsorbent polymer, the method capable of preparing the superabsorbent polymer maintaining excellent basic absorption performances such as centrifugal retention capacity, absorbency under load, etc. while also exhibiting an improved absorption rate.Type: ApplicationFiled: November 7, 2019Publication date: January 14, 2021Applicant: LG Chem, Ltd.Inventors: Yong Seok Choi, Yeon Woo Hong, Eunji Shin, Taebin Ahn
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Publication number: 20210008522Abstract: Provided are compositions for removal of a target substance from a fluid stream, the composition comprising a polyamine; and a covalently linked hydrophobic group, wherein the polyamine is covalently linked to a support material. Also provided are processes for removal of a target substance from a fluid stream comprising contacting the fluid stream with a composition comprising a polyamine; and a covalently linked hydrophobic group, wherein the polyamine is covalently linked to a support material.Type: ApplicationFiled: March 28, 2019Publication date: January 14, 2021Applicant: Puraffinity Ltd.Inventors: Benjamin David REEVE, Wen LI, Katharina REEH, Amanda Yi Fen YOU, Henrik HAGEMANN
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Publication number: 20210008523Abstract: An adsorbent bed, including at least one elementary composite structure that includes adsorbent particles in a polymer matrix, wherein the adsorbent bed has a bed packing, ?bed, defined as a volume occupied by the at least one elementary composite structure Vecs divided by a volume of the adsorbent bed Vbed where ?bed is greater than 0.60.Type: ApplicationFiled: July 11, 2020Publication date: January 14, 2021Applicants: L'Air Liquide, Societe Anonyme pour l'Etude et l'Exploitation des Procedes Georges Claude, Air Liquide Advanced Technologies U.S. LLCInventors: Philippe A. COIGNET, Dean W. KRATZER, Antoine PRUVOT, Matthew METZ
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Publication number: 20210008524Abstract: A SCR catalyst composition comprises a SCR catalyst; and a binder comprising a porous inorganic material, wherein the porous inorganic material comprises a disordered arrangement of delaminated layers, has a disordered porous structure, and has a multimodal pore size distribution comprising at least a first modal maximum having a macroporous or mesoporous pore size and a second modal maximum having a microporous pore size. The SCR catalyst composition can be manufactured using the method comprising the steps of: (i) providing an inorganic material having a layered structure; (ii) contacting the material with a cationic surfactant to form a swollen material; (iii) agitating the swollen material to form an agitated material; and (iv) calcining the agitated material to recover a delaminated inorganic material, wherein an SCR catalyst is mixed with the inorganic material prior to step (iv).Type: ApplicationFiled: August 10, 2020Publication date: January 14, 2021Inventors: Jürgen BAUER, Ralf DOTZEL, Joerg Werner MUENCH, Ralitsa PUROVA, Wilhelm SCHWIEGER, Thangaraj SELVAM, Ameen SHAHID
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Publication number: 20210008525Abstract: A crystal-orientation controlled complex comprising a connected assembly having a thin film shape, in which a plurality of crystal pieces are connected with each other, the crystal pieces having a flake shape and having a main surface and an end surface, wherein the main surface has a crystal orientation relative to a specific crystal plane, and the thin film shaped connected assembly has a polarization singularity.Type: ApplicationFiled: September 25, 2020Publication date: January 14, 2021Applicant: FURUKAWA ELECTRIC CO., LTD.Inventors: Yoshikazu TSUZUKI, Mariko WAKAE, Satoshi AOKI, Goro MIYOSHI
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Publication number: 20210008526Abstract: The present invention relates to methods of immobilising metals on polymeric surfaces using surfactants and to products that can be formed by such methods. Polymer substrates with metal immobilised on the surface are very useful in a variety of applications. The metal is usually in the form of a nanoparticle. A major use of the invention is in catalysts. The invention can also be used in medical applications, such as to make antimicrobial surfaces.Type: ApplicationFiled: September 18, 2018Publication date: January 14, 2021Applicant: PolyCatUK Ltd.Inventor: William PATERSON
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Publication number: 20210008527Abstract: The present invention relates to a process for preparing a cobalt-containing Fischer-Tropsch synthesis catalyst with good physical properties and high cobalt loading. In one aspect, the present invention provides a process for preparing a supported cobalt-containing Fischer-Tropsch synthesis catalyst, said process comprising the steps of: (a) impregnating a support material with cobalt haydroxide nitrate, or a hydrate thereof, of formula (I) below to form an impregnated support material, [Co(OH)x(NO3)(2-x).yH2O] (I) where: 0<x<2 0?y?6 (b) drying and calcining the impregnated support material.Type: ApplicationFiled: March 21, 2019Publication date: January 14, 2021Inventors: Alexander James Paterson, Zhaorong Zhang
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Publication number: 20210008528Abstract: Catalysts comprising nanostmctured elements comprising microstructured whiskers having an outer surface at least partially covered by a catalyst material comprising at least 90 atomic percent collectively Pt, Ni, and Ru, wherein the Pt is present in a range from 33.9 to 35.9 atomic percent, the Ni is present in a range from 60.3 to 63.9 atomic percent, and the Ru is present in a range from 0.5 to 9.9 atomic percent and wherein the total atomic percent of Pt, Ni, and Ru equals 100. Catalyst described herein are useful, 0 for example, in fuel cell membrane electrode assemblies.Type: ApplicationFiled: March 27, 2019Publication date: January 14, 2021Inventors: Andrew J. L. Steinbach, Sean M. Luopa, Andrew T. Haug, Amy E. Hester, Krzysztof A. Lewinski, Grant M. Thoma
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Publication number: 20210008529Abstract: The present disclosure provides methods of making confined nanocatalysts within mesoporous materials (MPMs). The methods utilize solid state growth of nanocrystalline metal organic frameworks (MOFs) followed by controlled transformation to generate nanocatalysts in situ within the mesoporous material. The disclosure also provides applications of the nanocatalysts to a wide variety of fields including, but not limited to, liquid organic hydrogen carriers, synthetic liquid fuel preparation, and nitrogen fixation.Type: ApplicationFiled: March 26, 2019Publication date: January 14, 2021Inventors: Ignacio LUZ MINGUEZ, Mustapha SOUKRI, Marty LAIL, Sameer PARVATHIKAR, Michael CARPENTER
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Publication number: 20210008530Abstract: Catalysts for producing one or more oxygenated products from methane are provided. In embodiments, the catalyst comprises active sites comprising isolated, cationic transition metal M? atoms covalently bound to internal surfaces of pores of a porous metal M? silicate, wherein M? is Rh or Ir, and further wherein the M? atoms are bound to five oxygen (O) atoms. Methods for making and using the catalysts are also provided.Type: ApplicationFiled: March 26, 2019Publication date: January 14, 2021Inventors: Franklin Tao, Weixin Huang, Yu Tang, Yuting Li
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Publication number: 20210008531Abstract: Provided is a catalyst article for simultaneously remediating the nitrogen oxides (NOx), particulate matter, and gaseous hydrocarbons present in diesel engine exhaust streams. The catalyst article has a soot filter coated with a material effective in the Selective Catalytic Reduction (SCR) of NOx by a reductant, e.g., ammonia.Type: ApplicationFiled: September 29, 2020Publication date: January 14, 2021Inventors: Joseph A. Patchett, Joseph C. Dettling, Elizabeth A. Przybylski
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Publication number: 20210008532Abstract: Systems and methods for providing alternative fuel, in particular hydrogen photocatalytically generated by a system comprising photoactive nanoparticles and a nitrogenase cofactor are provided. In one aspect, the system includes a water soluble cadmium selenide nanoparticle (CdSe) surface capped with mercaptosuccinate (CdSe-MSA) and a NafY.FeMo-co complex comprising a NafY protein and an iron-molybdenum cofactor (FeMo-co), wherein the CdSe-MSA and NafY.FeMo-co complex are present in about 1:2 to 1:10 molar ratio.Type: ApplicationFiled: March 13, 2019Publication date: January 14, 2021Inventors: Deborah B. Maxwell, Deidra L. Gerlach
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Publication number: 20210008533Abstract: Described are catalytic articles comprising a substrate having a washcoat on the substrate, the washcoat containing a catalytic component having a first average (D50) particle size and a functional binder component having a second average (D50) particle size in the range of about 10 nm to about 1000 nm, wherein the ratio of the first average (D50) particle size to the second average (D50) particle size is greater than about 10:1. The catalytic articles are useful in methods and systems to purify exhaust gas streams from an engine.Type: ApplicationFiled: September 9, 2020Publication date: January 14, 2021Inventors: Gary A. Gramiccioni, Jaya L. Mohanan, John K. Hochmuth, Kenneth R. Brown, Brian Todd Jones
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Publication number: 20210008534Abstract: An apparatus of coating a filter substrate comprising a plurality of channels and an apparatus is disclosed. The apparatus comprises: (i) a containment means for receiving a pre-determined amount of the liquid; and (ii) a liquid dosing head arranged to dispense the pre-determined amount of the liquid into the containment means over an upper end of the filter substrate. The containment means is locatable at an upper end of the filter substrate; and the liquid dosing head comprises a plurality of apertures for dispensing the liquid onto the upper end of the filter substrate.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Inventors: Kaneshalingham ARULRAJ, Jenita BHANTOO, Jamie SAVAGE, Andrew SMITH, Lifeng WANG, Daisuke YOKOTA
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Publication number: 20210008535Abstract: The method allows to produce catalysts with nanoparticles of platinum and its alloys with metals of a given composition, with high values of catalytic activity in an oxygen electroreduction reaction, and with predetermined values of structural characteristics. The method comprises preparation of a solution of chloroplatinic acid or a mixture of chloroplatinic acid with metal salts, mixing thereof with dispersed carbon or non-carbon carriers, their mixtures and compositions with specific surface area of more than 60 m2/g, dispersion of the obtained mixture, chemical reduction of compounds of platinum and a metal salt with subsequent deposition of nanoparticles of metallic platinum or its alloys on a dispersed carrier being carried out by purging gases selected from: nitrogen oxides (N2O, NO, NO2), carbon oxides (CO, CO2), sulfur oxide (SO2), ammonia (NH3) or their mixtures through the solution at a temperature of the solution in the range from 5 to 98° C.Type: ApplicationFiled: July 29, 2020Publication date: January 14, 2021Inventors: Anastasia Anatolyevna ALEKSEENKO, Sergey Valerievich BELENOV, Vladimir Efimovich GUTERMAN
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Publication number: 20210008536Abstract: The present invention provides a regeneration method and a regeneration device of a poisoning honeycomb catalyst, and belongs to the field of catalyst regeneration. The regeneration method of the poisoning honeycomb catalyst provided by the present invention includes the following steps: carrying out microwave heating treatment on the poisoning honeycomb catalyst, and then spraying liquid nitrogen into cells of the poisoning honeycomb catalyst so that the poisoning honeycomb catalyst is regenerated. The regeneration method provided by the present invention is simple, and the efficiency of the regenerated catalyst can be increased by 90% more than the original efficiency. According to the regeneration device of a poisoning honeycomb catalyst provided by the present invention, the catalyst regeneration is carried out by using the regeneration device provided by the present invention, the regeneration operation is simple, and the catalytic efficiency of the regenerated catalyst is improved.Type: ApplicationFiled: December 13, 2019Publication date: January 14, 2021Applicant: Hebei University of TechnologyInventor: Boxiong Shen
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Publication number: 20210008537Abstract: A process for removing Hg2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with a titanium metallate ion exchanger to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchanger. The titanium metallate ion exchangers are represented by the following empirical formula: AmTiNbaSixOy. A composition is provided with the combination of the titanium metallate ion exchanger and bodily fluids or dialysis solutions. Also, provided is an apparatus comprising a matrix and the titanium metallate ion exchanger.Type: ApplicationFiled: July 9, 2019Publication date: January 14, 2021Inventors: Gregory John Lewis, Paulina Jakubczak, Julio C. Marte, William Christopher Sheets
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Publication number: 20210008538Abstract: This present invention discloses a bifunctional adsorptive material capable of adsorbing both cations and anions in aqueous phase, obtainable by synthesizing aluminum ion doped SBA-15 molecular sieves from P123 triblock copolymers, tetraethoxysilane, and aluminum isopropoxide to obtain multiple cationic active adsorption sites, and by grafting large sterically hindered organic groups onto the surface of Al-SBA-15 to obtain multiple anionic active adsorption sites. This kind of adsorptive material has two types of adsorption sites for ions of opposite charges. The large sterically hindered organic groups prevent spontaneous recombination reaction between the two types of adsorption sites, enabling the adsorptive material to have excellent adsorption capacity for wastewater treatment involving both cations and anions.Type: ApplicationFiled: August 13, 2015Publication date: January 14, 2021Inventors: Yan Yu, Yajun He, Qiuping Wu, Zhiyu Liang
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Publication number: 20210008539Abstract: A continuous resin regeneration system includes a process by which resin in need of being recharged is continuously recharged and cleaned with a plurality of two-set filtration columns so that resin regeneration and the flow of influent is continuous and interrupted. Downstream filtration columns also undergo this cycling but at slower and related rates as the first column with the dirtiest water will naturally degrade resin faster than the downstream columns. Contaminated influent is cleaned by the continuously recharged resin in multiple column sets. The degree of cleaning of earlier filtration columns affects the resin flow rate of later filtration columns.Type: ApplicationFiled: July 9, 2020Publication date: January 14, 2021Inventors: Jay Vanier, Russell D. Pool
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Publication number: 20210008540Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath.Type: ApplicationFiled: June 15, 2020Publication date: January 14, 2021Inventors: Christopher PROCYSHYN, Marcin CICHY
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Publication number: 20210008541Abstract: Systems and methods for automated biological sample preparation for use in rapid identification and antimicrobial susceptibility testing of microorganisms, such as bacteria and fungi, are provided.Type: ApplicationFiled: June 22, 2020Publication date: January 14, 2021Inventors: Kevin Marshall, Austin Ashby, Josh Harrison, Steven W. Metzger, Wayne Showalter, Erik Molina, Jamie Roberson
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Publication number: 20210008542Abstract: A pipetting system is disclosed that includes a pipette head including a multichannel air displacement system for aspirating and dispensing liquids, a pipetting system base that includes a linear guide system along which the pipette head may be moved vertically with respect to the pipetting system base, and counterbalance means for counterbalancing at least a portion of a weight of the pipette head.Type: ApplicationFiled: September 22, 2020Publication date: January 14, 2021Inventor: Richard COTE
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Publication number: 20210008543Abstract: Systems and methods for handling a variety of sample and preparatory fluids in a rack specifically configured for compatibility with predetermined liquid handlers such as automated pipettors or multi-channel manual pipettors and set up for magnetic based sample preparation. The rack can hold all of the necessary sample and reagent vials, and present them to the pipettor in some embodiments in a way that allows for parallel operation. The rack includes slidable magnets that in some embodiments are actuatable directly by the pipettor, eliminating a layer of complexity. Combined with a suitable pipettor the magnet enabled rack supports a multistep magnetic based sample preparation capability in a high throughput manner at one station that enhances sample purity throughout magnetic separation processes.Type: ApplicationFiled: July 14, 2019Publication date: January 14, 2021Applicant: Zhuhai Sanmed Biotech LTDInventors: Behrad Vahidi, William M. Strauss, Mike Trejo, Xin Ye, Dongwen Li
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Publication number: 20210008544Abstract: A pipette module 10 has a pipette-module frame 12 attachable to the z-axis frame 120 of a liquid handling system 100. A translatory-motion frame 14 attached to the pipette-module frame 12 is movable with respect thereto by a motor 16. A pneumatic aspirator assembly 18 including a cylinder 20, tube 24, tube tip 26 and pressure sensor 28 is attached to the translatory-motion frame 14. A piston 22 disposed in the cylinder 20 is fixedly attached to the frame 12. A controller 30 for the pipette module 10 has a liquid surface detection mode which enables a pressure feedback control algorithm causing the motor 16 to move the translatory-motion frame 14 in a z-axis translator motion until a change in a pressure in the tip 26 as sensed by the pressure sensor 28 indicates that the tip 26 has made contact with the liquid surface 110.Type: ApplicationFiled: April 6, 2018Publication date: January 14, 2021Inventors: Hirofumi TAMAI, Chaojun ZHOU
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Publication number: 20210008545Abstract: This liquid handling device includes: a first flow passage through which a first liquid can flow; a second flow passage through which a second liquid can move; a third flow passage through which the second liquid can move; and a droplet generating unit, which is a merging portion of the second flow passage and the third flow passage with respect to the first flow passage, and which is configured in such a way that the first liquid flowing through the first flow passage is divided in the form of droplets by means of the second liquid flowing through the second flow passage and the third flow passage.Type: ApplicationFiled: February 25, 2019Publication date: January 14, 2021Applicant: Enplas CorporationInventors: Yuya OSHIMA, Nobuya SUNAGA
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Publication number: 20210008546Abstract: The invention concerns a hand-held device with a removable tip for dispensing an agent and/or sampling a fluid; a tip for use in connection therewith; wherein said tip is additionally provided with at least one abutment member located on the outside of said tip, and a container for use therewith which is adapted to facilitate the removal of tips from said device and to receive same for disposal. The invention further includes a method for attaching and ejecting a tip from said hand-held device by rotating the tip with respect to said device to bring about alignment of the alignment guides until a best fit is achieved; and ejecting the tip from the hand-held device by inserting the tip into said container and aligning said abutment member on said tip with the boundary corresponding to same in said aperture then rotating said tip with respect to said device to eject the tip from the device.Type: ApplicationFiled: May 12, 2017Publication date: January 14, 2021Inventors: Dieter Wilhelm TRAU, Abhinav JAIN, Shihao LI
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Publication number: 20210008547Abstract: Examples disclosed herein relate to a device. Examples include a region selection engine to determine a plurality of regions on a well plate, a number of wells in each region, and a location of each well in each region; and a dispense engine to determine a quantity of DNA concentrate under 1 microliter to dispense in each well of the plurality of regions on the well plate, and the dispense engine to control a fluid dispensing device to eject the quantity of DNA concentrate into each well of each region of the well plate. In examples, a quantity of DNA fragments in the DNA concentrate is unknown.Type: ApplicationFiled: September 15, 2017Publication date: January 14, 2021Applicant: Hewlett-Packard Development Company, L.P.Inventors: Hilary ELY, Adam HIGGINS, Christie DUDENHOEFER, Jeffrey A. NIELSEN
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Publication number: 20210008548Abstract: Devices, systems, methods, and kits are disclosed for amplifying small quantities of nucleic acid and identifying the nucleic acid sequences of the amplified nucleic acid products.Type: ApplicationFiled: June 23, 2020Publication date: January 14, 2021Inventor: Jason Yingjie LIU
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Publication number: 20210008549Abstract: In one aspect, the inventive concepts disclosed herein are directed to a sensor assembly which contains a first planar substrate and a second planar substrate which respectively support opposing sensor arrays and contains an integrated flow path extending between the first and second substrates.Type: ApplicationFiled: September 29, 2020Publication date: January 14, 2021Applicant: Siemens Healthcare Diagnostics Inc.Inventor: Jennifer A. Samproni
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Publication number: 20210008550Abstract: This disclosure describes various microfluidic devices that may be used in thermal cyclic fluid samples. Some of these devices may include a plurality of microwells that may be coupled by interconnected fluidic channels. These microwells may not be physically separated and yet may include features allowing for effective isolation of target molecules within each microwell. Other devices may include a plurality of microwells that may not be interconnected. The devices may also include mechanisms for causing a fluid to flow across the device. The devices may also include light-absorbing films for converting light energy to heat so as to allow for thermal cycling of samples within the microwells.Type: ApplicationFiled: July 8, 2020Publication date: January 14, 2021Inventors: Jun Ho Son, Luc Bousse
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Publication number: 20210008551Abstract: A flow channel chip has: a common flow channel; introduction flow channels that are respectively connected to the common flow channel; introduction valves that are respectively disposed in the introduction flow channels; a cleaning liquid flow channel that is connected to the common flow channel; and a cleaning liquid valve that is disposed in the cleaning liquid flow channel. This fluid handling device has: a rotary member for controlling opening/closing of the introduction valves; and a cleaning liquid valve control unit for controlling opening/closing of the cleaning liquid valve. After the rotary member is rotated so as to open/close one of the introduction valves, the cleaning liquid valve control unit causes the cleaning liquid valve to open and causes the cleaning liquid to flow in the common flow channel before the rotary member is rotated so as to open/close another of the introduction valves.Type: ApplicationFiled: March 28, 2019Publication date: January 14, 2021Inventors: Nobuya SUNAGA, Takumi YAMAUCHI, Satomi YABUUCHI
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Publication number: 20210008552Abstract: Nucleic acid extraction and purification cartridges and systems are provided. The cartridges can be removable and are configured to allow for the concentration of particles of interest, followed by nucleic acid extraction and purification. The cartridges directly contact samples and provide a partial barrier between samples and the reusable components of the system, thereby reducing the probability of clogging the system's microfluidics and fouling the lines, valves, and pumps of the system. Furthermore, these cartridges are designed to purity nucleic acids by removing the majority of inhibitors for down-stream genetic testing. Embodiments may comprise one, two, or three or more channels.Type: ApplicationFiled: June 14, 2018Publication date: January 14, 2021Inventors: John REGAN, John DePiano
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Publication number: 20210008553Abstract: The present disclosure provides methods and systems for separating one or more target analytes from a fluid sample. The systems may comprise a microfluidic device. The microfluidic device may comprise a fluidic channel having an array of obstacles disposed therein. The array of obstacles may be oriented at an angle greater than 0° relative to a direction of a fluid flow in the fluidic channel. The array of obstacles may be configured to separate the target analytes from the fluid upon flow of the fluid through the fluidic channel. The methods of the present disclosure may comprise separating target analytes from a fluid using a microfluidic device comprising obstacles disposed in a fluidic channel of the device. The target analytes may be separated with a high efficiency, sensitivity and/or specificity.Type: ApplicationFiled: April 29, 2020Publication date: January 14, 2021Inventors: Daojing WANG, Yuchao CHEN, Pan MAO
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Publication number: 20210008554Abstract: A capturing of target cells from a biological sample is achieved by inducing a flow of the biological sample in a flow channel (30, 60) of an upstream microfluidic device (1). Target cells present in the biological sample are captured in cell channels (20) of the upstream microfluidic device(1). Once at least a minimum number of target cells are captured in the cell channels (20), the flow of the biological sample in the flow channel is reduced and are verse flow is applied at the upstream microfluidic device (1) to release the target cells captured in the cell channels (20) of the upstream microfluidic device (1) and enable transfer the target cells into cell channels (120) of a downstream microfluidic device (100).Type: ApplicationFiled: February 15, 2019Publication date: January 14, 2021Inventors: Özden BALTEKIN, Ove ÖHMAN, Martin LOVMAR, Johan ELF, Mikael OLSSON
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Publication number: 20210008555Abstract: Described herein are devices and systems that can be configured to and/or capable of monitoring and/or controlling fluid flow within microchannels and/or vessels in a microphysiological model. Described herein are aspects of a system configured to monitor and/or control fluid flow in a microfluidic device that can include a manifold device, where the manifold device can include an inlet reservoir, an outlet reservoir, a pressure jumper, a sensor, and a scaffold block that can have a plurality of microfluidic channels and/or vessels. Also described herein are methods of making and using the systems and devices described herein.Type: ApplicationFiled: March 12, 2019Publication date: January 14, 2021Inventors: Michael DANIELE, Patrick D. ERB
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Publication number: 20210008556Abstract: A method of operating an electrowetting on dielectric (EWOD) device performs electrowetting operations on fluids dispensed into the EWOD device, which provides enhanced operation for using multiple non-polar filler fluids.Type: ApplicationFiled: July 8, 2019Publication date: January 14, 2021Inventors: Lesley Anne Parry-Jones, Emma Jayne Walton
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Publication number: 20210008557Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements.Type: ApplicationFiled: December 21, 2018Publication date: January 14, 2021Applicants: Oxford Nanopore Technologies Ltd., Sharp Life Science (EU) LtdInventors: Matthew HOLDEN, James WHITE, Andrew John HERON, James Anthony CLARKE, Jason Robert HYDE, Benjamin James HADWEN, Sally ANDERSON
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Publication number: 20210008558Abstract: The objective of the present invention is to provide a fluid handling device capable of easily isolating droplets. This objective is achieved by means of a fluid handling device which includes a first flow passage through the interior of which, when a fluid containing a droplet is delivered, the droplet can move, a first chamber which captures the droplet moving through the first flow passage, a second chamber into which the droplet captured by the first chamber can move, and a second flow passage providing communication between the first chamber and the second chamber, wherein the second flow passage is capable of selectively allowing the droplet to pass, or restricting passage of the droplet.Type: ApplicationFiled: February 18, 2019Publication date: January 14, 2021Applicant: Enplas CorporationInventor: Nobuya SUNAGA
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Publication number: 20210008559Abstract: Disclosed herein are methods and devices for preparing a dried reagent for long term storage and rehydrating and mixing the dried reagent.Type: ApplicationFiled: December 8, 2017Publication date: January 14, 2021Inventors: Thomas H. CAULEY, III, Melvin YAMAMOTO
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Publication number: 20210008560Abstract: Instrument for performing a diagnostic test on a fluidic cartridge A cartridge reader is for carrying out a diagnostic test on a sample contained in a fluidic cartridge inserted into the reader. The fluidic cartridge comprises a fluidic layer comprising at least one sample processing region, at least one collapsible blister containing a liquid reagent, a pneumatic interface, an electrical interface and at least one mechanical valve. The reader comprises a housing; an upper clamp occupying a fixed position relative to the reader, and a lower clamp, movable relative to the first clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween. The reader comprises a thermal module comprised in the lower clamp, wherein the thermal module comprises at least one thermal stack for heating the at least one sample processing region of the cartridge inserted into the reader.Type: ApplicationFiled: May 8, 2020Publication date: January 14, 2021Inventors: Ben Arlett, Tom Edwards
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Publication number: 20210008561Abstract: An insert for a liquid-holding container may include a body comprising a wall, an open top end and a bottom end, and a generally tubular lumen extending from the open top end to the open bottom end. The insert may include a plurality of first openings formed in the wall, the first openings being situated between the top and bottom ends, wherein each of the plurality of first openings defines an area, and wherein the plurality of first openings have substantially the same dimensions. The insert may include one or more second openings formed in the wall, the one or more second openings being situated between the top and bottom ends, wherein each of the one or more second openings defines an area that is greater than the area defined by any of the first openings, wherein the one or more second openings have substantially the same dimensions.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Applicant: Gen-Probe IncorporatedInventors: Byron J. KNIGHT, Vincent CHABOT