Patents Issued in January 14, 2021
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Publication number: 20210009462Abstract: The purpose of the present invention is to provide a glass for chemical strengthening that exhibits a high strength after chemical strengthening and is resistant to devitrification. The present invention relates to a glass for chemical strengthening that contains, expressed as mol% on an oxide basis, 55 to 70% SiO2, 10 to 25% Al2O3, 1 to 20% Li2O, 0 to 8% CaO, 0 to 8% SrO, and 0 to 5% ZrO2, in which the sum of the contents of CaO and SrO is 1.5 to 10%, the sum of the contents of Na2O and K2O is 3 to 11%, and the value X given by the formula ([Li2O]+[K2O])/[Al2O3] is 0.1 to 1.1.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Applicant: AGC Inc.Inventors: Suguru MURAYAMA, Akio KOIKE
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Publication number: 20210009463Abstract: A glass ceramic sintered body having a small dielectric loss in a high frequency band of 10 GHz or higher and a wiring substrate using the same are provided. The glass ceramic sintered body contains crystallized glass, an alumina filler, and silica. The content of the crystallized glass is 45 mass % to 85 mass %, the content of the alumina filler is 14.8 mass % to 50.1 mass % in terms of Al2O3, and the content of silica is 0.2 mass % to 4.9 mass % in terms of SiO2.Type: ApplicationFiled: July 8, 2020Publication date: January 14, 2021Applicant: TDK CORPORATIONInventors: Shin TAKANE, Yousuke FUTAMATA, Kenichi SAKAI, Yasuharu MIYAUCHI
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Publication number: 20210009464Abstract: A glass ceramic sintered body having a small dielectric loss in a high frequency band of 10 GHz or higher and stable characteristics against temperature variation and a wiring substrate using the same are provided. The glass ceramic sintered body contains crystallized glass, an alumina filler, silica, and strontium titanate. The content of the crystallized glass is 50 mass % to 80 mass %, the content of the alumina filler is 15.6 mass % to 31.2 mass % in terms of Al2O3, the content of silica is 0.4 mass % to 4.8 mass % in terms of SiO2, and the content of the strontium titanate is 4 mass % to 14 mass % in terms of SrTiO3.Type: ApplicationFiled: July 8, 2020Publication date: January 14, 2021Applicant: TDK CORPORATIONInventors: Shin TAKANE, Yousuke FUTAMATA, Yasuharu MIYAUCHI
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Publication number: 20210009465Abstract: A glass composition, a macrocomposite, and methods of forming the macrocomposite including dispersing or immersing a metal in a glass. Preferably, the macrocomposite does not include an organic resin, an adhesive, or a polymer.Type: ApplicationFiled: April 20, 2017Publication date: January 14, 2021Applicant: UPTERIOR, LLCInventors: Agnieszka Zielinska, Anna Zielinska, Marian Klisch
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Publication number: 20210009466Abstract: A composite plate is mainly made from the following raw materials in percentage by weight: 35% to 45% of calcium carbonate, 45% to 55% of cullet, 5% to 15% of unsaturated polyester resin, 0.1% to 1% of a curing agent, 0.1% to 1% of an auxiliary agent, wherein a ratio of an amount of the calcium carbonate to an amount of the cullet is 0.75%. The invention employs cullet, calcium carbonate, and resin as the main raw materials to prepare an artificial stone plate; no natural quartz is used, and hence the raw material cost is low. A reasonable ratio of cullet to calcium carbonate reduces the use of resin, which further reduces the raw material cost. Through a reasonable combination of different raw materials, the composite plate of the invention has physical and chemical properties and decorative abilities that are similar to those of traditional artificial quartz stone.Type: ApplicationFiled: October 13, 2019Publication date: January 14, 2021Inventors: Guoming Zhang, Jiansong Xian, Zhijian Liang, Junxian Liu, Ting Liu
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Publication number: 20210009467Abstract: A method for forming a via in a glass article includes forming one or more cavities within a glass substrate by exposing the glass substrate to an etchant, the glass substrate including a glass cladding layer and a glass central core layer, where the glass cladding layer has an etch rate in the etchant that is different than an etch rate of the glass central core layer, and where the one or more cavities extend through the glass central core layer terminating at the glass cladding layer, depositing a metallic material within the one or more cavities, and removing the glass cladding layer.Type: ApplicationFiled: April 2, 2019Publication date: January 14, 2021Inventors: Hoon Kim, Jin Su Kim
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Publication number: 20210009468Abstract: A cooking appliance includes a cooking chamber, a door that is configured to open and close the cooking chamber and has a door glass, a coating layer that is disposed at least one surface of the door glass and made of a coating composition. The coating composition includes 20 to 40 wt % of phosphorus pentoxide (P2O5), 15 to 30 wt % of aluminum oxide (Al2O3) and zirconium dioxide (ZrO2), 10 to 30 wt % of sodium oxide (Na2O) and potassium oxide (K2O), 10 to 25 wt % of boron trioxide (B2O3), and 10 to 15 wt % of zinc oxide (ZnO).Type: ApplicationFiled: July 10, 2020Publication date: January 14, 2021Inventors: Taehee KIM, Dongwan SEO, Taeho KIM, Ju Hyeong KIM, Yongsoo LEE
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Publication number: 20210009469Abstract: Methods for evaluating a chemically strengthened housing component for an electronic device are disclosed. These methods may allow non-destructive determination of whether the chemical strengthening of the component meets specifications.Type: ApplicationFiled: June 17, 2020Publication date: January 14, 2021Inventors: Tyler A. Marshall, Christopher C. Bartlow
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Publication number: 20210009470Abstract: One or more aspects of the disclosure pertain to an article including a film disposed on a glass substrate, which may be strengthened, where the interface between the film and the glass substrate is modified, such that the article has an improved average flexural strength, and the film retains key functional properties for its application. Some key functional properties of the film include optical, electrical and/or mechanical properties. The bridging of a crack from one of the film or the glass substrate into the other of the film or the glass substrate can be suppressed by inserting a nanoporous crack mitigating layer between the glass substrate and the film.Type: ApplicationFiled: September 30, 2020Publication date: January 14, 2021Inventors: Heather Bossard Decker, Shandon Dee Hart, Guangli Hu, James Joseph Price, Paul Arthur Sachenik
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Publication number: 20210009471Abstract: A method for manufacturing a glass panel unit, which reduces the amount of a getter material to enable a gettering ability to be realized at a relatively low temperature less likely to cause damage. The method includes a step of producing a getter material by heating an unprocessed getter material at a temperature higher than a prescribed temperature Te; a step of producing a preassembled component including a first and second glass pane, a heat-fusible sealing material, an internal space, and a gas adsorbent containing the getter material, and an evacuation port; a step of forming a frame body hermetically bonding the first glass pane and the second glass pane together by melting the heat-fusible sealing material with heat; and a step of heating the gas adsorbent at the prescribed temperature Te while the internal space is evacuated by exhausting air in the internal space through the evacuation port.Type: ApplicationFiled: March 15, 2019Publication date: January 14, 2021Inventors: Hiroyuki ABE, Eiichi URIU, Kazuya HASEGAWA, Tasuku ISHIBASHI, Masataka NONAKA, Takeshi SHIMIZU, Haruhiko ISHIKAWA
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Publication number: 20210009472Abstract: A lightweight composite composition includes a plurality of lightweight particles including a volume of at least about 10% of a total volume of the lightweight composite composition. The plurality of lightweight particles includes an average bulk density within a range from about 0.001 g/cc to about 1.5 g/cc and an average particle size within a range from about 0.01 microns to about 90 mm. Methods of manufacturing a lightweight composite composition are provided.Type: ApplicationFiled: July 8, 2020Publication date: January 14, 2021Inventors: Norman G. Schabel, JR., David Schabel, Doug Gorski
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Publication number: 20210009473Abstract: The present invention relates to a method of producing a SiC—Si composite component. The method includes preparing a first molded body containing SiC particles by a 3D printing method, wherein the first molded body has a first average pore diameter M1; forming a second molded body, in which the first molded body and a dispersion containing carbon particles are brought into contact so that the pores are impregnated with the carbon particles, wherein the carbon particles have a secondary particle having an average particle diameter M2, and the carbon particles satisfy the following formula: M2?M1/10; and forming a SiC—Si composite component by carrying out that the second molded body is impregnated with a metallic Si and is reactively sintered; wherein the content of Si is in the range of 5% by mass to 40% by mass in the SiC—Si composite component.Type: ApplicationFiled: September 23, 2020Publication date: January 14, 2021Applicant: AGC Inc.Inventors: Kenji YAMADA, Kenichiro TERADA, Nobuhiro SHINOHARA, Shinya KIKUGAWA, Yasuo SHINOZAKI, Shunsuke SUSA
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Publication number: 20210009474Abstract: The present disclosure relates to a heating element, wherein at least one part of the heating element is manufactured from a molybdenum disilicide composition and wherein in the molybdenum disilicide composition, molybdenum is substituted by chromium according to (Mo1-xCrx)Si2 and x is in the range of 0.16?x?0.19.Type: ApplicationFiled: March 15, 2019Publication date: January 14, 2021Applicant: Sandvik Intellectual Property ABInventors: Erik STRÖM, Petter LINDBLOM
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Publication number: 20210009475Abstract: The present disclosure relates to a heating element comprising at least two parts which are composed of different molybdenum disilicide-based compositions, wherein at least one of the molybdenum disilicide-based parts is based on a chromium-alloyed based molybdenum disilicide composition ((Mo1-xCrx)Si2 where x is of from 0.05 to 0.25); and at least one part is based on a molybdenum disilicide-based composition comprising more than or equal to 90 weight % Mo(Si,Al)2. The present disclosure also relates to the use of the heating element.Type: ApplicationFiled: March 15, 2019Publication date: January 14, 2021Applicant: Sandvik Intellectual Property ABInventor: Erik STRÖM
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Publication number: 20210009476Abstract: A baking slurry composition of the present invention contains an amino alcohol compound represented by formula, inorganic powder , a polyvinyl alcohol resin, and water. In the formula, R is a hydrogen atom or an alkyl group having a carbon number larger than or equal to 1 and smaller than or equal to 20, and m and n being values satisfying conditions m?0, n?0, and m+n?1.Type: ApplicationFiled: March 13, 2019Publication date: January 14, 2021Inventor: Yutaka KAWAI
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Publication number: 20210009477Abstract: A baking slurry composition for producing a green sheet of the present invention contains inorganic powder, a polyvinyl alcohol resin, acrylic polymer, and water. The acrylic polymer has a glass transition temperature higher than or equal to ?50° C. and lower than or equal to 30° C. and an acid value greater than or equal to 50 mg KOH/g and less than or equal to 200 mg KOH/g. The acrylic polymer has a weight percentage of more than or equal to 0.1 and less than or equal to 5.0 relative to a total solid content of the baking slurry composition.Type: ApplicationFiled: March 13, 2019Publication date: January 14, 2021Inventor: Yutaka KAWAI
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Publication number: 20210009478Abstract: A green sheet producing binder composition of the present invention is a binder composition for producing a green sheet. The binder composition contains a polyvinyl alcohol resin. The polyvinyl alcohol resin contains at least two kinds of components having degrees of hydrophilicity different from each other.Type: ApplicationFiled: March 13, 2019Publication date: January 14, 2021Inventor: Yutaka KAWAI
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Publication number: 20210009479Abstract: A method for infiltrating a porous preform for a gas turbine engine is provided, which comprises providing a chamber for infiltrating a porous preform. The porous preform is positioned within a slurry confinement fixture within the chamber. A vacuum is created in the chamber. A solvent is added to the slurry confinement fixture until a pressure in the chamber is substantially equal to an equilibrium partial pressure of the solvent. A slurry is added to the slurry confinement fixture. The slurry includes the solvent and a particulate. The pressure in the chamber is increased, and the slurry is urged into the porous preform.Type: ApplicationFiled: July 11, 2019Publication date: January 14, 2021Applicant: Rolls-Royce High Temperature Composites Inc.Inventors: Thomas E. Krause, Robert Shinavski, Kevin Mark Lukhard
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Publication number: 20210009480Abstract: A method of altering a surface of a ceramic matrix composite to aid in nodule removal is described. A fiber preform comprising a framework of ceramic fibers is heated to a temperature at or above a melting temperature of silicon. During the heating, the fiber preform is infiltrated with a molten material comprising silicon. After the infiltration, the fiber preform is cooled, and the infiltrated fiber preform is exposed to a gas comprising nitrogen during cooling. Silicon nitride may be formed by a reaction of free (unreacted) silicon at or near the surface of the infiltrated fiber preform with the nitrogen. Thus, a ceramic matrix composite having a surface configured for easy nodule removal is formed. Any silicon nodules formed on the surface during cooling may be removed without machining or heat treatment.Type: ApplicationFiled: July 9, 2020Publication date: January 14, 2021Applicant: Rolls-Royce High Temperature Composites Inc.Inventors: Christopher Whitmore, Stephen Harris, Sungbo Shim, Timothy Western
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Publication number: 20210009481Abstract: Systems and methods for manufacturing an organic liquid fertilizer product are shown. The contemplated systems and methods are configured to treat waste from a natural source in order to produce the organic liquid fertilizer. The liquid organic waste may be derived from an organic source. The liquid organic waste may be pre-treated through an anaerobic digestion process, or it may be treated in a raw form. Advantageously, the systems and methods of the present disclosure may be used to manufacture the organic liquid fertilizer with a sufficiently high nitrogen content, which is usable by plants and crops. The systems and methods are likewise more efficient than known systems and methods to produce such fertilizer products.Type: ApplicationFiled: July 9, 2020Publication date: January 14, 2021Inventors: Robert Levine, Scott D. Severson
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Publication number: 20210009482Abstract: A treated biochar comprising a porous carbonaceous particle that has been treated and mixed with a media containing a mineral solubilizing microorganism, whereby the porous carbonaceous particle after mixing has retained the mineral solubilizing microorganism.Type: ApplicationFiled: June 29, 2020Publication date: January 14, 2021Inventors: Richard W. Belcher, Han Suk Kim, Brian Buege, Ronald A. Sills
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Publication number: 20210009483Abstract: Methods and systems are provided for generating and utilizing a bacterial composition that comprises at least one genetically engineered bacterial strain that fixes atmospheric nitrogen in an agricultural system that has been fertilized with more than 20 lbs of Nitrogen per acre.Type: ApplicationFiled: September 21, 2020Publication date: January 14, 2021Inventors: Karsten Temme, Alvin Tamsir, Sarah Bloch, Rosemary Clark, Emily Tung, Kevin Hammill, Douglas Higgins, Austin Davis-Richardson
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Publication number: 20210009484Abstract: An organic composition for decomposing bodily remains including a composite mixture of compost, peat, sulfur, and gypsum. The composite mixture is configured to combine with the bodily remains to decompose the bodily remains. The combined mixture has a reduced pH for reducing the detrimental effects of the bodily remains on the environment.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Inventors: Robert L. Jenkins, Annette Jenkins
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Publication number: 20210009485Abstract: Disclosed is a method of coating fertilizer particles with a coating, the method comprising providing fertilizer particles in a coating unit, one or more steps of applying a coating layer by applying one or more coating components to the fertilizer particles in the coating unit, and at least, partially curing or hardening the coating layer, wherein said curing or hardening involves a chemical reaction of said one or more coating components, discharging the coated fertilizer particles from the coating unit, optionally after a final cure or hardening step, wherein the coating unit comprises a stationary frame and at least two movable elements.Type: ApplicationFiled: June 4, 2019Publication date: January 14, 2021Inventors: Joseph Anthony SAIIA, James Taylor PURSELL, Jr., Stephen Mark BROOKS, Leon ROBERSON, II, Spencer Daniel SANDERS, Allen Zorn SANDERS, Murray Paul HASINOFF, Daniel Paul HEBERER, Justin McLean FOGARTY, Kristopher Michael MODRZYNSKI
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Publication number: 20210009486Abstract: The present disclosure provides assemblies for producing linear alpha olefins and methods for producing linear alpha olefins. In at least one embodiment, a method for producing a linear alpha olefin includes oligomerizing an olefin in the presence of a catalyst and a process solvent in at least one reactor, quenching the reactor effluent, and subjecting the quenched effluent to separation steps to obtain a stream enriched in one or more linear alpha olefins.Type: ApplicationFiled: December 4, 2018Publication date: January 14, 2021Inventors: Paul W. Allen, Kirk C. Nadler, James R. Lattner, Michael W. Weber, Travis A. Reine, Robert M. Koros, Roger N. Bennett
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Publication number: 20210009487Abstract: A method for producing p-xylene, comprising: a dimerization step of bringing a first raw material comprising isobutene into contact with a dimerization catalyst to generate C8 components comprising diisobutylene; a cyclization step of bringing a second raw material comprising the C8 components into contact with a dehydrogenation catalyst comprising Pt in the presence of water to obtain a reaction product comprising p-xylene; and a collection step of collecting p-xylene from the reaction product.Type: ApplicationFiled: March 19, 2019Publication date: January 14, 2021Applicant: ENEOS CorporationInventors: Ai MINODA, Masanari AKIYAMA, Yasuhiro ARAKI
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Publication number: 20210009488Abstract: A method for producing p-xylene, comprising: a dimerization step of bringing a first raw material comprising isobutene into contact with a dimerization catalyst to generate C8 components comprising diisobutylene; a cyclization step of bringing a second raw material comprising the C8 components into contact with a dehydrogenation catalyst comprising Pt in the presence of hydrogen to obtain a reaction product comprising p-xylene; and a collection step of collecting p-xylene from the reaction product.Type: ApplicationFiled: March 19, 2019Publication date: January 14, 2021Applicant: ENEOS CorporationInventors: Ai MINODA, Masanari AKIYAMA, Yasuhiro ARAKI, Masakazu IKEDA, Mayumi YOKOI
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Publication number: 20210009489Abstract: The present invention provides a process for preparing an 11-halo-3-undecene compound (7) in which X1 represents a halogen atom, the process comprising a step of subjecting a nucleophilic reagent, 3-hexenyl compound (5): in which M2 represents Li or MgZ2, wherein Z2 represents a halogen atom or a 3-hexenyl group, to a coupling reaction with a 1-halo-5-halopentane compound (6) in which X3 and X4 may be same with or different from each other and represent a halogen atom, to produce the 11-halo-3-undecene compound (7).Type: ApplicationFiled: July 7, 2020Publication date: January 14, 2021Inventors: Yuki Miyake, Takeshi Kinsho, Ryo Komatsu
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Publication number: 20210009490Abstract: The present invention provides highly efficient processes for the preparation of chlorinated alkanes. The processes comprise contacting an alkene, halogenated alkene, or combinations thereof, a halogenated methane comprising at least one chlorine atom, at least one solid metallic catalyst, and a ligand forming a reaction mixture in a reactor. The product mixture does not contain a phase transfer catalyst. After a product mixture is formed, various fractions, distillation streams, and effluent streams are separated and/or treated with an aqueous alkaline substance. This treatment removes at least a portion of the metal and through recycling of the heavy fraction, treated product mixture, or combinations thereof, allows for the kinetics of the process to be maintained or increased.Type: ApplicationFiled: April 2, 2019Publication date: January 14, 2021Applicant: Blue Cube IP LLCInventor: John D. Myers
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Publication number: 20210009491Abstract: A method of producing carbon tetrachloride, the method comprising the step of reacting chlorine with chloroform in the presence of electromagnetic radiation within a reaction mixture that includes the chlorine, the chloroform, and carbon tetrachloride, where the concentration of chloroform is less than 5000 ppm by weight relative to the weight of the reaction mixture, where the reaction mixture includes at least stoichiometric levels of chlorine relative to chloroform, where the electromagnetic radiation creates chloride radicals, and where the reaction mixture is well mixed.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Inventors: Robert L. ZELLER, Darrell HOLLIS, Keith S. KRAMER, Brian CALDERWOOD, Rodney L. KLAUSMEYER
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Publication number: 20210009492Abstract: The invention provides a method for preparing phenols from aromatic compounds, particularly a method of preparing phenol by direct hydroxylation of benzene. The method comprises contacting benzene with nitrous oxide in the presence of a bimetallic zeolite catalyst at an ambient pressure and a reaction temperature ranging from (about) 320° C. to 440° C.Type: ApplicationFiled: January 17, 2017Publication date: January 14, 2021Applicants: The King Abdulaziz City for Science and Technology, Leibniz Institute for Catalysis at the University of Rostock (LIKAT)Inventors: Mansour Shuleiweeh Alotaibi, Venkata Narayana Kalevaru, Andreas Martin, Mohammed Alkinany, Hamid A Al-Megren
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Publication number: 20210009493Abstract: A method for preparing dimethylolbutanal including performing an aldol reaction of n-butyraldehyde (n-BAL) and paraformaldehyde (PFA) in the presence of water and an alkylamine catalyst, in which a weight ratio of the paraformaldehyde:water is 1:0.35 to 1:0.85.Type: ApplicationFiled: July 10, 2019Publication date: January 14, 2021Inventors: Min Ji CHOI, Sungshik EOM, Dawon JUNG, Tae Yun KIM, Dong Hyun KO, Mi Young KIM
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Publication number: 20210009494Abstract: The present application discloses methods for the efficient preparation of high purity compounds of the Formula I, and their methods of use.Type: ApplicationFiled: September 18, 2020Publication date: January 14, 2021Applicant: Epizon Pharma, Inc.Inventors: Keith E. Drouet, James A. Tumlin, John M. Rudey
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Publication number: 20210009495Abstract: The present invention relates to a method for isomerizing a 3-(Z)-unsaturated carboxylic acid of the formula 1-Z or a salt thereof, wherein R2 is C1-C24-alkyl, C2-C24-alkenyl having 1, 2, 3 or more than 3 C—C double bonds, unsubstituted or substituted C5-C12-cycloalkyl, or unsubstituted or substituted aryl; R1 is hydrogen or has one of the definitions specified for R2; with the proviso that R2 has a higher priority than R1 in accordance with IUPAC; to give a 3-(E)-unsaturated carboxylic acid of the formula I-E or a salt thereof, wherein the isomerization of the compound of the formula 1-Z is effected in the presence of an anhydride of an organic acid and a base or in the presence of a ketene of formula CR11R12C(0), wherein R11 and R12 are as defined in the claims and in the specification and a base.Type: ApplicationFiled: February 13, 2019Publication date: January 14, 2021Inventors: Mathias SCHELWIES, Wolfgang SIEGEL, Rocco PACIELLO, Andreas KELLER
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Publication number: 20210009496Abstract: The disclosure provides methods and apparatus for producing 3-hydroxypropionic acid or a salt thereof, for removing 3-hydroxypropionic acid from aqueous solution (e.g., aqueous broth), and for using it to make various chemicals.Type: ApplicationFiled: October 25, 2018Publication date: January 14, 2021Inventors: Jeung Yeop Shim, Ki Soo Park, Ashok Somasundar, Sung Hoon Park
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Publication number: 20210009497Abstract: We disclose quinone compounds and related species (Formula I) that possess significant advantages when used as a redox active material in a battery, e.g., a redox flow battery. In particular, the compounds provide redox flow batteries (RFBs) with extremely high capacity retention. For example, RFBs of the invention can be cycled for 500 times with negligible loss of capacity, and such batteries could be employed for years of service. Thus, the invention provides a high efficiency, long cycle life redox flow battery with reasonable power cost, low energy cost, and all the energy scaling advantages of a flow battery.Type: ApplicationFiled: February 11, 2019Publication date: January 14, 2021Inventors: Michael J. AZIZ, Roy G. GORDON, Kaixiang LIN, David Gator KWABI, Yunlong JI
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Publication number: 20210009498Abstract: Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.Type: ApplicationFiled: April 30, 2019Publication date: January 14, 2021Inventors: Jaipal SINGH, Kerry FOWLER
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Publication number: 20210009499Abstract: An object of the present invention is to provide a method for producing an unsaturated carboxylic ester, wherein the risk of polymerization blockage is reduced and the required equipment cost and workload involved are kept low while maintaining a high conversion rate in an esterification reaction of unsaturated carboxylic acid. This object can be achieved by a method for producing an unsaturated carboxylic ester, which includes performing an esterification reaction using a reactor packed with a solid catalyst, wherein unsaturated carboxylic acid and alcohol are continuously fed to the reactor from an inlet thereof to form a fluid of the reaction solution in the reactor, and the vaporized organic solvent is continuously fed to the reactor from the inlet or a part near the inlet of the reactor.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Applicant: Mitsubishi Chemical CorporationInventors: Yasushi OGAWA, Risa KATAYAMA
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Publication number: 20210009500Abstract: A method for producing a fatty acid polyoxyethylene methyl ether in which ethylene oxide is added to a fatty acid methyl ester component comprising, as a main component, a fatty acid methyl ester having a fatty acid residue of 18 to 22 carbon atoms, the addition being conducted in the presence of a composite metal oxide catalyst and at least one alcohol selected from the group consisting of diethylene glycol, ethylene glycol, propylene glycol, ethanol, methanol and isopropyl alcohol.Type: ApplicationFiled: December 20, 2018Publication date: January 14, 2021Applicant: Lion CorporationInventors: Akinori JOKO, Masahiro SATO, Fumiya NIIKURA
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Publication number: 20210009501Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.Type: ApplicationFiled: July 22, 2020Publication date: January 14, 2021Applicant: CORSAIR PHARMA, INC.Inventors: Xiaoming ZHANG, Meenakshi S. VENKATRAMAN, Cyrus K. BECKER
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Publication number: 20210009502Abstract: The invention relates to carbonate-linked surface modifying macromolecules and admixtures thereof. The admixtures can be used in industrial and medical applications where enhanced surface properties are desirable (e.g., surface properties reducing or preventing biofouling, immobilization of biomolecules, or denaturation of certain biomolecules).Type: ApplicationFiled: March 7, 2019Publication date: January 14, 2021Inventors: J. Paul Santerre, Sanjoy Mullick
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Publication number: 20210009503Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.Type: ApplicationFiled: August 3, 2020Publication date: January 14, 2021Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
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Publication number: 20210009504Abstract: The present invention provides methods of synthesizing (6S,15S)-3,8,13,18-tetraazaicosane-6,15-diol and salts thereof.Type: ApplicationFiled: July 27, 2020Publication date: January 14, 2021Inventors: P. Sathya Shanker, Sankappa Rai U, Murali Venghatraghavan, Selvam Vengatesan, Rahul Patil, Padavalachandu Bharathkumar
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Publication number: 20210009505Abstract: The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.Type: ApplicationFiled: July 3, 2020Publication date: January 14, 2021Inventors: Matthew ANGEL, Franklin Kostas, Christopher Rohde
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Publication number: 20210009506Abstract: A compound, or a pharmaceutically acceptable salt thereof, having a formula I of: wherein Ar is an arylene or heteroarylene; R1 has a structure of: wherein W is an alkanediyl, alkenediyl, a carbonyl, or a combination thereof; X is —NR5—, wherein R5 is H or an alkyl, or —O—; and Y is optionally-substituted cycloalkyl, optionally-substituted cycloalkyl-substituted alkyl, optionally-substituted heterocycloalkyl, or optionally-substituted heterocycloalkyl-substituted alkyl; each R2 is the same or different and has a structure of: wherein Z is —NR6—, wherein R6 is H or an alkyl, —O—, —S—, or —CH2—; Z1 is (—CH2-)m wherein m is 0 to 5, or an alkenediyl having 2 to 6 carbon atoms; Cy is a 3-8-membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring; and each R4 is the same or different and is selected from hydroxy, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, or amino; and c is 0 to 5; and each R3 is the same or different and is selected from hyType: ApplicationFiled: July 29, 2020Publication date: January 14, 2021Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventor: Xiangqun Xie
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Publication number: 20210009507Abstract: The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative.Type: ApplicationFiled: March 29, 2019Publication date: January 14, 2021Applicants: Heidelberg Pharma Research GmbH, Corden Pharma International GmbHInventors: Caroline Knittel, Mary-Ann Siegert, Roderich Süssmuth, Christoph Wink, Gerhard Jas
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Publication number: 20210009508Abstract: Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.Type: ApplicationFiled: July 23, 2020Publication date: January 14, 2021Inventors: Martin D. Burke, Junqi Li, Eric P. Gillis
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Publication number: 20210009509Abstract: The instant invention describes hydrazide-containing compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.Type: ApplicationFiled: August 21, 2020Publication date: January 14, 2021Inventors: Daiqing LIAO, William R. ROUSH, Ryan L. STOWE
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Publication number: 20210009510Abstract: Provided herein are a variety of metal chelators as well as methods of use thereof.Type: ApplicationFiled: August 28, 2017Publication date: January 14, 2021Inventors: Rebecca J. ABERGEL, Julian REES, Roland K. STRONG, llya CAPTAIN
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Publication number: 20210009511Abstract: A series of phenelzine analogs comprising a phenelzine scaffold linked to an aromatic moiety and their use as inhibitors of lysine-specific demethylase 1 (LSD1) and/or one or more histone deacetylases (HDACs) is provided. The presently disclosed phenelzine analogs exhibit potency and selectivity for LSD1 versus MAO and LSD2 enzymes and exhibit bulk, as well as, gene specific histone methylation changes, anti-proliferative activity in several cancer cell lines, and neuroprotection in response to oxidative stress. Accordingly, the presently disclosed phenelzine analogs can be used to treat diseases, conditions, or disorders related to LSD1 and/or HDACs, including, but not limited to, cancers and neurodegenerative diseases.Type: ApplicationFiled: June 4, 2020Publication date: January 14, 2021Inventors: Philip Cole, Shonoi Ming, Polina Prusevich, Jay Kalin