Abstract: It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein.

Abstract: Monoclonal antibodies (MAbs) targeting one or more specific epitopes of aspartyl (asparaginyl) ?-hydroxylase (ASPH), including humanized, bi-specific, and other chimeric MAb variants, and fragments thereof (collectively ASPH epitope-specific MAbs, or simply ASPH MAbs), are disclosed. Methods of production, purification, and use of the ASPH epitope-specific MAbs, and compositions comprising them, as agents in therapeutic and diagnostic applications to interact with target molecules in cell-free samples, cell- and tissue-based assays, animal models, and in a subject are also disclosed. Other aspects of the invention relate to use of the molecules disclosed herein to diagnose, ameliorate, or treat cell proliferation disorders and related diseases.

Abstract: Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).

Abstract: The present invention provides novel compounds that are useful as radiopharmaceuticals, imaging agents and for treatment of cancer.

Abstract: The present disclosure relates to compositions and methods for treating disease. More particularly, the disclosure relates to synthetic proteins and their use for treating cancer.

Abstract: The present invention belongs to the technical field of biological pharmacy, and particularly relates to a long-acting HM-3 fusion protein molecule and an application thereof. In the present invention, on the basis of the sequence of HM-3 molecule, an active polypeptide HM-3 and derivatives thereof are linked to a human Fc (IgG) fragment or a fragment of an Fc (IgG) mutant directly or by a linker peptide (Linker), thus forming a novel molecular entity. The general formula of the molecular entity is (HM-3)n-Linker-Fc(IgG), Fc(IgG)-Linker-(HM-3)n, or (HM-3)n-Linker-Fc(IgG)-Linker-(HM-3)n. The fusion protein effectively prolongs the half-life of HM-3, is low in cost and overcomes the major problem of druggability of small peptides. Therefore, the fusion protein of the present invention may serve as a potential drug for the treatment of autoimmune diseases, neovascular diseases, osteoarthritis and the like.

Abstract: Provided are FLT3L-Fc fusion proteins, polynucleotides encoding such fusion proteins, expression cassettes, vectors, cells and kits comprising such fusion proteins, and methods of using.

Abstract: The present invention relates to peptide conjugates of cytotoxins such as topoisomerase I inhibitors which are useful for the treatment of diseases such as cancer.

Abstract: The present invention relates to an immunocytokine in which a human interferon-beta variant is conjugated to an antibody or a fragment thereof, and a method for preparing the same.

Abstract: A continuous process for pre-contacting coordination polymerization catalyst components with each other before they are introduced into a polymerization reactor at 130 degrees Fahrenheit to 200 degrees Fahrenheit, where the activated coordination catalyst is contacted with at least one monomer to produce amorphous poly alpha olefin (APAO). Embodiments of the process involves blending a metallocene pre-catalyst with an organic solvent forming a metallocene pre-catalyst solution and flowing a co-catalyst mixture into the metallocene pre-catalyst solution continuously in a pre-contacting device, forming an activated metallocene catalyst. Embodiments further involve continuously injecting the activated metallocene catalyst into the heated polymerization reactor while simultaneously and continuously injecting propylene monomer and/or other alpha-olefin monomers, and hydrogen gas for molecular weight control, initiating an exothermic reaction forming a monomer-polymer-catalyst slurry.

Abstract: A modified conjugated diene-based polymer and a rubber composition including the same are disclosed herein. In some embodiments, a modified conjugated diene-based polymer includes a 1,2-vinyl bond content of 30.0 wt % or less with respect to a total weight of the modified conjugated diene-based polymer, wherein the polymer has a glass transition temperature of ?90° C. to ?50° C., a mooney viscosity of 50 to 100 measured by ASTM D1646, polydispersity index (PDI) of 1.5 to 3.5, and a mooney relaxation ratio of 0.7 or less when measured at 110° C.

Abstract: The invention relates to acid-labile, crosslinked polymers.

Abstract: A transparent sheet for freeing formed floor and wallboard from coating with UV paint and coating, including following raw materials in parts by weight: 100 parts of PVC resin powder, 25-40 parts of plasticizer, 2-5 parts of stabilizer and 1-2 parts of lubricant. A method for preparing the transparent sheet: (1) weighing the raw materials according to a ratio of the PVC resin powder, the plasticizer, the stabilizer and the lubricant; and filtering the raw materials; (2) mixing the filtered raw materials and calendering the mixture by a calender to obtain a transparent sheet blank; (3) ultraviolet-curing the transparent sheet blank and coating a wear-resistant agent onto the transparent sheet blank to obtain the transparent sheet.

Abstract: The present invention relates to super absorbent polymer and a method for preparing the same. According to the super absorbent polymer and preparation method for the same of the present invention, super absorbent polymer having improved rewet property and vortex time can be provided.

Abstract: Poly(aryl piperidinium) polymers with pendant cationic groups are provided which have an alkaline-stable cation, piperidinium, introduced into a rigid aromatic polymer backbone free of ether bonds. Hydroxide exchange membranes or hydroxide exchange ionomers formed from these polymers exhibit superior chemical stability, hydroxide conductivity, decreased water uptake, good solubility in selected solvents, and improved mechanical properties in an ambient dry state as compared to conventional hydroxide exchange membranes or ionomers. Hydroxide exchange membrane fuel cells comprising the poly(aryl piperidinium) polymers with pendant cationic groups exhibit enhanced performance and durability at relatively high temperatures.

Abstract: An object is to provide a chlorinated polyolefin resin that has excellent solution stability and excellent adhesion to polyolefin substrates including a polyethylene substrate. The chlorinated polyolefin resin is a chlorinated product of a copolymer having a structural unit derived from ethylene, in which a content ratio of the ethylene structural unit in the copolymer is 50 mol % to 90 mol %.

Abstract: Described herein are cationic polymers having a plurality of quaternary amino groups, methods of making such polymers, and uses of such polymers as ion exchange membranes in electrochemical devices.

Abstract: A copolymer of ethylene and of myrcene, in which the ethylene units represent between 50 mol % and 95 mol % of the ethylene units and of the myrcene units, and the myrcene units of 1,2 and 3,4 configuration represent more than 50 mol % of the myrcene units, is provided. Such a copolymer exhibits an improved compromise between the degree of crystallinity and the stiffness. It therefore makes it possible to widen the field of application of ethylene-rich diene copolymers in rubber compositions, and also to increase the production capacity of a unit for the synthesis of ethylene-rich diene polymers.

Abstract: An object of the present invention is to provide a novel ethylene/?-olefin/non-conjugated polyene copolymer containing a certain non-conjugated polyene such as VNB as a copolymerization component, having a low long-chain branching content, excellent in cure characteristics in the case of crosslinking by using peroxide, and having good processability. The ethylene/?-olefin/non-conjugated polyene copolymer according to the present invention has constitutional units derived from ethylene (A), an ?-olefin (B) having 3 to 20 carbon atoms, and a non-conjugated polyene (C) having a total of two or more partial structures selected from the group consisting of the following general formulas (I) and (II) in a molecule, and satisfies certain requirements.

Abstract: The present disclosure relates to compositions comprising a copolymer derived from polymerizing monomers comprising a vinyl aromatic monomer, butadiene, and an acid monomer, in the presence of a chain transfer agent. The chain transfer agent can be present in an amount sufficient to reduce the theoretical glass transition temperature (Tg) of the copolymer by at least 5° C. compared to a copolymer polymerized using identical monomers in the absence of the chain transfer agent. The compositions can be used to prepare compositions such as coatings that have improved water resistance. Methods of making the copolymers are also provided.

Abstract: To provide a method for producing modified polytetrafluoroethylene, in which formation of a fluorinated oligomer as a by-product is little. A method for producing modified polytetrafluoroethylene which contains substantially no C6-34 fluorinated oligomer containing hydrophilic functional groups and which contains substantially no fluorinated surfactant, the method comprising conducting copolymerization of tetrafluoroethylene and a monomer having a polar group, in a liquid dispersion 1 comprising a polymer containing units derived from a non-fluorinated monomer and an aqueous medium, or in a solution 2 obtainable by mixing at least one member selected from the group consisting of a polyalkylene oxide compound and a hydrocarbon-containing surfactant, with an oxidizing agent, in an aqueous medium, under such a condition that the amount of the monomer having a polar group to be used, is at most 0.150 mass % to the whole amount of tetrafluoroethylene, to obtain modified polytetrafluoroethylene.

Abstract: To provide a method for fractionating a liquid composition, which is excellent in separability of the liquid composition. This method for fractionating a liquid composition comprises discharging, from a discharge port of a filling nozzle, a liquid composition containing a solvent and a polymer having ion exchange groups, and fractionating a predetermined amount of the liquid composition, characterized in that the temperature of the liquid composition is controlled so that the average tan ?1 of the liquid composition when discharged from the discharge port of the filling nozzle becomes to be at most 1.00.

Abstract: A process for preparing an aqueous polymer dispersion, the process including forming a copolymer A from at least one ?,?-monoethylenically unsaturated C3 to C6 monocarboxylic acid (monomers A1) and at least one other monoethylenically unsaturated compound (monomers A2); reacting the copolymer A with a metal compound M in an aqueous medium; and conducting free-radical polymerization of at least one ethylenically unsaturated compound (monomer P) in the presence of the copolymer A in an aqueous medium.

Abstract: An acrylic rubber containing acrylate monomer units, methacrylate monomer units, and crosslinkable monomer units, wherein a glass transition temperature is ?20° C. or less, a change ratio in volume after a crosslinked rubber of the acrylic rubber is immersed in IRM903 oil at 150±2° C. for 72 hours is 0 to 100%, and a change ratio in weight after a crosslinked rubber of the acrylic rubber is immersed in hot water at 150±2° C. for 96 hours and dried is ?5.0 to 0%.

Abstract: Provided are: a core-corona polymer particle excellent in emulsion stability and feeling of use, and a raw material for a cosmetic and an oil-in-water emulsion cosmetic comprising the particle. Certain embodiments of the present invention provide a core-corona polymer particle obtained by radical-polymerizing a polyethylene oxide macromonomer represented by formula (1) and one or two or more of hydrophobic monomers represented by formulas (2) and (3) under conditions (A) to (D).

Abstract: A solution that can be used for trapping at least one toxic chemical agent, the solution comprising at least one protic solvent, at least one monomer comprising an (alkyl)acrylic, (alkyl)acrylate or (alkyl)acrylamide group, at least one crosslinking agent comprising at least two groups chosen from the (alkyl)acrylic, (alkyl)acrylate or (alkyl)acrylamide groups, at least one photopolymerization initiator, at least one thixotropic filler and at least one agent chosen from alkali metal halides, alkali metal phosphates, alkali metal sulfates and mixtures thereof.

Abstract: Described herein are polymeric aminoacrylates formed by the reaction of polyalkylene glycol diacrylates with bireactive amines. The polymeric aminoacrylate are comprised of moieties of poly(alkylene glycol) diacrylate and moieties of bireactive amines. Also described herein are energy curable ink and coating compositions that include the described polymeric aminoacrylates. The energy curable ink and coating compositions that include the described polymeric aminoacrylates are well-suited for use in packaging applications where low migration of uncured monomer material after cure is desired, such as in the packaging of foodstuffs, pharmaceuticals, etc.

Abstract: The present invention provides a (meth)acrylic acid copolymer-containing composition which can sufficiently exhibit both stability at low temperatures and a calcium phosphate scale inhibition ability. The present invention relates to a (meth)acrylic acid copolymer-containing composition containing a (meth)acrylic acid copolymer including: a structural unit (a) derived from at least one selected from the group consisting of (meth)acrylic acid and salts thereof; and a structural unit (b) derived from a sulfonic acid monomer (B), the copolymer containing the structural unit (b) in a proportion of 5 to 90 mol % based on 100 mol % of all structural units, and having a weight average molecular weight of 4,500 to 18,000, the composition containing a sulfur-containing inorganic component not incorporated into the copolymer at a concentration of 6,000 ppm or lower in terms of sulfur atoms.

Abstract: The present invention relates to a precursor composition for (meth) acrylic thermoplastic composites, its method of preparation and its use. In particular it relates to a semi-fabricated composition comprising a (meth) acrylic polymer, a monomer, a fibrous material and at least one initiator. More particularly the present invention relates to a precursor composition comprising a (meth) acrylic polymer, a monomer, a fibrous material and at least two initiators. The present invention relates also to a method of preparation of a composition comprising a (meth) acrylic polymer, a monomer, a fibrous material and at least two initiators.

Abstract: Disclosed is a preparation method of a polycarboxylate water reducer having a regular sequence structure. The preparation method of the present invention comprises: performing Michael addition on polyethylene glycol ether acrylate macromonomer A and amino-containing carboxylic acid B for 5-12 hours, then cooling to 0° C., dropwise adding acryloyl chloride slowly and evenly, and further reacting for 12 hours at room temperature to obtain carboxyl-containing polyether macromonomer C; mixing the carboxyl-containing polyether macromonomer C, a small molecular RAFT reagent, an initiator, and water adequately; and holding the polymerization mass concentration at 30%-60% and heating to 60-80° C. in the atmosphere of N2 to react for 2-5 hours to obtain the polycarboxylate water reducer having a regular sequence structure.

Abstract: Provided are reactive silicon group-containing polymers and a curable composition containing said polymers. The curable composition provides a cured product having a low modulus, flexibility, excellent tensile strength, tensile elongation, and tear strength. The curable composition can also exhibit excellent rapid curing properties even when a low-activity catalyst has been added. In the reactive silicon group-containing polymer, a reactive silicon group, indicated by general formula (1): (—Si(R1)3-a(X)a), is bonded to the molecular chain of the polymer and an atom adjacent to the reactive silicon group has an unsaturated bond. In general formula (1), each R1 can independently indicate a C1-20 hydrocarbon group, and the R1 hydrocarbon groups can be substituted and a hetero-containing group can be used. X can be a hydroxyl group or a hydrolyzable group, and a is 1, 2, or 3.

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

Abstract: A phase difference film composed of a resin containing a copolymer including polymerization units A and B, the phase difference film including a cylindrical phase separation structure that generates a structural birefringence, the phase separation structure including a phase (A) having the polymerization unit A as a main component and a phase (B) having the polymerization unit B as a main component, and the phase difference film satisfying the following condition (1) or (2). Condition (1): D(A)>D(B) and f(B)>0.5, and a direction giving a maximum refractive index among in-plane directions and an orientation direction of a cylinder in the phase separation structure are parallel to each other. Condition (2): D(A)>D(B) and f(A)>0.5, and a direction giving a maximum refractive index among in-plane directions and an orientation direction of a cylinder in the phase separation structure are orthogonal to each other.

Abstract: Processes for manufacturing novolacs and resoles from lignin are disclosed. A phenol-aldehyde-lignin dispersion is formed which can then be used to make either a novolac or a resole, depending upon the catalysts used.

Abstract: A polymerizable composition for an optical material includes a prepolymer which is a reaction product of a first amine compound (A1) having a weight-average molecular weight of less than 4,000, a first diol compound (B1) having a viscosity (25° C.) of equal to or less than 100 mPa·s, and a polyisocyanate compound (C); and a first polythiol compound (D1), in which the first amine compound (A1) is at least one selected from a polyetheramine and an aromatic amine, and the first polythiol compound (D1) includes a dithiol compound (d1) having two mercapto groups and a polythiol compound (d2) having equal to or more than three mercapto groups.

Abstract: Recovery times and/or airflow of flexible polyurethane foam is increased by including certain tackifiers in the foam formulation. The tackifiers are formed into an emulsion that includes a polyether containing oxyethylene groups, a nonionic surfactant and certain fumed silica, carbon black or talc particles.

Abstract: The present invention discloses modified epoxy acrylates and the solder resist containing the epoxy modified acrylates, belonging to the synthetic resin field. In this invention, modified epoxy acrylates are prepared by introducing long fatty hydrocarbon chain as the branched chain into the carboxylated epoxy acrylates. The as-prepared solder resist containing this modified epoxy acrylates maintains the excellent property of photosensitive solder resist such as good adhesion, hardness, solvent resistance and weather resistance which facilities sensitivity and alkaline development during exposure simultaneously. This has led to good water resistance, electrical insulation of the cured products. Furthermore, the cured product also shows good flexibility which improves its application in photosensitive imaging ink materials.

Abstract: A curable resin composition containing: a curable resin; and a curing agent containing an imide oligomer, the imide oligomer containing an aliphatic diamine residue- and/or aliphatic triamine residue-containing imide oligomer that has, in a main chain, an imide skeleton and a substituted or unsubstituted aliphatic diamine residue having a carbon number of 4 or greater and/or a substituted or unsubstituted aliphatic triamine residue having a carbon number of 4 or greater, has a crosslinkable functional group at an end, and has a molecular weight of 5,000 or less. The curable resin composition is excellent in flexibility and processability before curing and excellent in adhesiveness, heat resistance, and dielectric characteristics after curing. An adhesive, an adhesive film, a circuit board, an interlayer insulating material, and a printed wiring board each produced using the curable resin composition are also provided.

Abstract: A 3D printing resin composition for a biomaterial and method for 3D printing the composition are disclosed. The composition comprises: (i) a pre-polymer comprising a polymeric unit of the general formula (-A-B-)n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1, (ii) at least one photo-initiator, and (iii) at least one light blocker.

Abstract: A copolymer characterized by alternating or semi-alternating ester and anhydride bonds, methods for its production and use thereof, particularly as a carrier for drug delivery, are described herein.

Abstract: A piezoelectric actuator is provided, including a vibration plate, a piezoelectric layer, a plurality of individual electrodes arranged in two arrays, first and second common electrodes which have first and second facing portions facing parts of the individual electrodes and first and second connecting portions connecting the first and second facing portions respectively, and first and second wiring portions which are arranged on the vibration plate and which are connected to the first and second common electrodes respectively via first and second connecting wirings, wherein one of the first connecting wirings connects the first connecting portion and one of the first wiring portion while striding over the second connecting portion.

Abstract: Provided are methods of producing sulfur- and phosphorus-containing polymers from beta-lactones. The sulfur- and phosphorus-containing polymers include bio-based sulfur- and phosphorus-containing polymers that may be obtained from renewable sources.

Abstract: A build material for additive manufacturing applications is disclosed. The build material includes a build composition in powder form. The build composition includes a semi-crystalline polymer having a glass transition temperature of at least 60° C. as measured by DSC and a minimum crystallization half-time of greater than 100 minutes as measured by SALS. A semi-crystalline polymer useful in additive manufacturing applications, an additive manufacturing method for producing a three-dimensional object and an additive-manufactured polymer article are also described.

Abstract: A type of wool-like polyester filament and preparing method thereof are disclosed. The preparing method is manufacturing filament from a modified polyester through a POY process and a successive DTY processes, wherein the modified polyester is the product of the esterification and the successive polycondensation reactions of evenly mixed terephthalic acid, 1,4-butanediol, fluorinated dicarboxylic acid, tert-butyl branched hexanediol and 2,5,6,6-tetramethyl-2,5-heptanediol. The obtained fiber has a dye uptake of 90.32-93.27% and a K/S value of 22.15-23.42 when dyed at 100° C., and has an intrinsic viscosity drop of 17-20% when stored at 25° C. and R.H. 65% for 60 months. This invention features a method with ease of application and a product with good dyeing and degradation performance.

Abstract: A method for purifying a specific trityl group-containing monodispersed polyethylene glycol from a mixture containing the trityl group-containing monodispersed polyethylene glycol and a specific ditritylated impurity. The method includes performing steps (A), (B) and (C). Step (A): a step of esterifying the hydroxyl group of the trityl group-containing monodispersed polyethylene glycol by a specific method; Step (B): a step of extracting the esterified compound by a specific method; and Step (C): a step of hydrolyzing the esterified compound to obtain the trityl group-containing monodispersed polyethylene glycol.

Abstract: A branched monodispersed polyethylene glycol represented by the formula (1): wherein X1 is a functional group that forms a covalent bond upon a reaction with a functional group present in a biofunctional molecule; n is an integer of 4 to 50, which represents number of repeating units of ethylene oxide units; and L1 represents a single bond, —NH—, -L2-(CH2)m1— or -L2-(CH2)m1-L3-(CH2)2-, L2 represents an ether bond, an amide bond, an urethane bond or a single bond, L3 represents an ether bond, an amide bond or an urethane bond, and m1 and m2 represent each independently an integer of 1 to 5.

Abstract: A method for manufacture of PEEK-PEDEK copolymers is disclosed along with copolymers formed by the method and their use. The method includes a nucleophilic polycondensation of a mixture of dihydroxybenzene and dihydroxybiphenyl with 4,4?-dihalobenzophenone in a reaction mixture comprising sodium carbonate and potassium carbonate, in an aromatic sulfone solvent, at a reaction temperature rising to a temperature from 280° C. to 330° C. immediately prior to the addition of a reaction-stopping salt, such as LiCI or Li2SO4, to the reaction mixture. Further organic dihalide is subsequently added to the reaction mixture for end-capping of the copolymer. The resulting copolymer has reduced chain branching and reduced melt viscosity at low shear rate compared to prior art copolymer of comparable molecular mass.

Abstract: A resin composition comprises a prepolymer of crosslinking agent and benzoxazine resin and a maleimide resin. The resin composition may be used to make various articles, such as a prepreg, a resin film, a resin-coated copper, a laminate or a printed circuit board, and achieves improvements in at least one, more or all of the properties including laminate reflow shrinkage, T288 thermal resistance, ten-layer board T300 thermal resistance, dissipation factor, copper foil peeling strength, and resin filling property in open area.

Abstract: A polyamic acid according to one or more embodiments of the present invention contains a structural unit represented by general formula (1) and a structural unit represented by general formula (2). In general formula (1), the plurality of R1s are each independently a hydrogen atom, a monovalent aliphatic group or an aromatic group. In general formula (2), the plurality of R2s are each independently an alkyl group having 1-3 carbon atoms or an aryl group having 6-10 carbon atoms. In general formulas (1) and (2), X is a tetravalent organic group. In general formula (2), the plurality of Ys are each independently an alkylene group having 1-3 carbon atoms or an arylene group having 6-10 carbon atoms, and m is an integer of 51-199.

Abstract: Provided is a fluorosilicone resin and a preparation method thereof. Using pentafluorostyrene as raw material, pentafluorophenethyldimethylchlorosilane is prepared by a hydrosilylation reaction. By means of a polycondensation reaction of the pentafluorophenethyldimethylchlorosilane, trimethylchlorosilane and tetraethyl orthosilicate, a pentafluorophenyl silicone resin is prepared. The preparation method adopts a two-step polycondensation process, which overcomes the disadvantages of a large difference in hydrolysis reactivity between pentafluorophenyldimethylchlorosilane and a copolymerized trialkyl-chlorosilane, and achieves a high yield. The obtained pentafluorophenyl silicone resin has the advantages of superior heat resistance, simple preparation process, low equipment requirements, high availability of raw material, and suitability for mass production. The heat-resistant fluorosilicone resin can be applied in a polymer material, such as a heat-resistant adhesive.