Abstract: A negative pressure wound therapy system includes at least one sensor coupled to a wound dressing for a wound of a patient, and a control circuit. The at least one sensor is configured to output an indication of a displacement of the wound dressing. The control circuit is configured to receive the indication of the displacement of the wound dressing, calculate a therapy parameter corresponding to the indication of the displacement, and output the therapy parameter.

Abstract: A blood pump comprises a pump casing a blood flow inlet and a blood flow outlet connected by a passage, and an impeller. The impeller comprises blades configured to convey blood from the blood flow inlet to the blood flow outlet, the impeller being supported in the pump casing by at least one contact-type bearing comprising a surface of the impeller facing a surface of the pump casing. At least one wash out channel extends through the impeller and is in fluid connection with the passage via a first opening and with the bearing via a second opening. The wash out channel is operatively associated with a secondary pump for pumping blood through the wash out channel towards the bearing. The secondary pump is formed at least partially by said at least one wash out channel extending through the impeller along a direction having at least one tangential directional component.

Abstract: An apparatus (1) for CRRT is provided comprising a blood circuit (10, 20, 30, 60) with a blood removal line (20), a treatment unit (10), and a blood return line (30). A replacement fluid container (78) is configured for containing a medical fluid, a pre-infusion line (70) has a first end (70-1) connected to the replacement fluid container (78) and a second end (70-2) connected to the blood removal line (20) and a blood pump (22) is active on the blood circuit. A replacement fluid pump (72) is active on the pre-infusion line (70), a dialysate circuit (40, 50, 70) comprises an effluent line (50) configured for discharging fluid from the second chamber, and a control unit (80) is connected to the replacement fluid pump (72) and to the blood pump (22) and is configured for performing a rinse-back procedure for restituting blood to a patient.

Abstract: The present invention relates to a supply device for a channel, in particular within a hollow catheter, and to a method for operating a supply device of this type that supplies a channel with a liquid and has two pumps arranged at points of the channel distanced from one another, characterised in that the parameter values of at least one operating parameter of both pumps are coordinated with one another in a controlled manner. As a result of the method, interruption-free and precisely controllable operation is to be ensured with simple structural means, in particular in the case of use of wear-free diaphragm pumps.

Abstract: Catheter blood pumps that include an expandable pump portion, which include an expandable impeller housing. The housings include an expandable blood conduit that defines a blood lumen, and one or more pluralities of expandable struts extending axially from an end region of the expandable blood conduit. At least one of the pluralities of struts are non-unitary with a blood conduit at the end region.

Abstract: Apparatus and methods are described including a blood pump catheter that includes an axial shaft, and an impeller disposed on the axial shaft. A motor drives the impeller to pump blood, by rotating the impeller. A drive cable extends from the motor to the axial shaft, the drive cable being configured to impart rotational motion from the motor to the impeller by rotating. A distal tip portion is disposed at a distal end of the blood pump catheter. The drive cable, the axial shaft, and the distal tip portion define a continuous lumen therethrough from outside the subject's body to the distal end of the blood pump catheter. The continuous lumen facilitates insertion of the blood pump catheter into the subject's body over a guidewire, and, subsequently, provides a channel through which the purging fluid flows. Other applications are also described.

Abstract: Apparatus and methods are described including a blood pump that includes an impeller, and a motor configured to drive the impeller to pump blood by rotating the impeller. The impeller is configured to undergo axial motion, in response to changes in a pressure against which the impeller is pumping. A sensor detects the axial motion of the impeller, and generates a sensor signal in response thereto. A computer processor receives the sensor signal and generates an output in response thereto. Other applications are also described.

Abstract: Apparatus and methods are described including a ventricular assist device that includes a tube configured to traverse a subject's aortic valve. The tube defines a generally-cylindrical central portion, and a proximal conical portion that narrows from a proximal end of the central portion to a proximal end of the tube. The tube defines one or more blood inlet openings in a vicinity of a distal end of the tube, and one or more blood outlet openings that extend axially from the central portion of the tube at least partially into the proximal conical portion of the tube. A blood pump pumps blood into the tube from the subject's left ventricle through the one or more blood inlet openings, and from the tube into the aorta through the one or more blood outlet openings. Other applications are also described.

Abstract: An extremely lightweight and compact heating system greatly increasing patient mobility is provided. The use of a flat plate can be used to greatly decrease package size and weight while providing comparable heat transfer by exploiting the ability of the dialysis bags to conform to this surface and through the greater heating area possible with the flat plate design. A short rim around the plate provides centering and protecting against minor leakage without substantially increasing package height. Protection against leakage is buttressed by sealing the rim to the plate and the use of 12 V only within the heating unit. The result is a lightweight warming device with a short that can be easily transported by the patient greatly improving patient lifestyle and freedom.

Abstract: In some embodiments, a medical system includes a dialysis machine having at least one outer surface to be disinfected at a given location, at least one disinfection sensor connected to the dialysis machine at the given location, the disinfection sensor including two or more electrode in fluid contact with the outside surface of the dialysis machine, and a conductivity sensor component in electrical contact with the two or more electrodes, the conductivity sensor component configured to send an electrical signal indicating a conductivity of a liquid on an outside surface of the dialysis machine and in contact with the two or more electrodes, a processor configured to receive the electrical signal and thereby determine a disinfection status of the given location, and a user interface configured to indicate the disinfection status of the given location.

Abstract: According to embodiments, priming systems, methods, and devices are disclosed which allow medical treatment devices which pump fluid to be primed with minimal operator intervention and a high level of convenience. A blood circuit with a filter fitted with one or more air vents on a non-blood compartment is attached to a treatment system and priming fluid pumped slowly through the blood circuit in a loop. The source of fluid may be elevated, or the pumping may generate pressure, such that priming fluid is forced through the membrane of the filter and out the air vent(s). In embodiments, the vents are hydrophobic which prevent fluid from being ejected, so the priming system can run without intervention.

Abstract: The present disclosure provides extracorporeal membrane oxygenation (ECMO) apparatuses treated to comprise lubricating liquid surfaces, hydrophobic or omniphobic surfaces, and/or fluid and solid repellant slippery surfaces that do not stimulate clotting and thrombus formation to the same degree as do the untreated surfaces. The apparatuses permit ECMO procedures to be conducted using less anticoagulant and/or antiplatelet medications than is possible with untreated apparatuses. Also described are methods of using the treated apparatuses to accomplish ECMO procedures on subjects (e.g., human patients) and upon perfused organs.

Abstract: Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

Abstract: A medical fluid injection device includes a pump, a communication part, a pump control part, and a storage part. The pump control part is configured to control the pump to start medical fluid injection when the communication part receives a start signal, and to stop the medical fluid injection when the communication part receives a stop signal, and the storage part is configured to store start inputter information together with start instruction information including information indicating that an instruction of starting the medical fluid injection is given, and stop inputter information together with stop instruction information including information indicating that an instruction of stopping the medical fluid injection is given.

Abstract: The present disclosure relates to apparatuses and methods of depot delivery of therapeutic agents. The apparatuses provide a drug delivery device including a catheter component having a stem portion and a branch portion. The catheter component includes a pre-defined bend such that the branch portion is angled with respect to the stem portion at an obtuse angle. The branch portion includes a dissecting head and at least one delivery port. The device includes a dilation balloon positioned on the branch portion between the pre-defined bend and the dissecting head, a drug delivery reservoir fluidly coupled to the at least one drug delivery port and a handle portion.

Abstract: An apparatus, system and method for regulating fluid flow are disclosed. An apparatus for infusing fluid into a patient infusion apparatus includes a drip-chamber seat configured to receive a drip chamber; a tube seat configured to receive a tube fluidly coupled to the drip chamber, the tube including a plurality of conduits for fluid flow therethrough; a plunger configured to engage with the tube; and a user actuator configured to actuate the plunger.

Abstract: A cassette usable with an infusion pump includes a monolithic cassette body and a segment of resiliently deformable tubing for conveying a flow of liquid. The monolithic cassette body has an integrally formed free-flow protection device including a fixed pinch element and a deflectable pinch arm having a movable pinch element. The pinch arm normally resides in a closed position wherein the pinch elements cooperate to deform the tubing segment to stop flow. The pinch arm is resiliently deflectable away from the closed position to an open position permitting flow. Deflection of the pinch arm away from the closed position spring biases the pinch arm for automatic return to the closed position. The pinch arm may be moved to the open position by operating a door of the pump when the cassette is loaded in the pump, and manually for priming when the cassette is not loaded in the pump.

Abstract: A fluid injector system includes at least one fluid reservoir having at least one interior surface and defining an internal volume, at least one actuator configured to change the internal volume of the at least one fluid reservoir, and at least one processor. The at least one processor may be programmed or configured to drive the actuator to at least partially fill the at least one fluid reservoir with a fluid from a fluid source, drive the actuator to generate a least a partial vacuum within the internal volume to dislodge one or more gas bubbles adhered to the at least one interior surface and to cause the one or more gas bubbles to coalesce into a coalesced bubble, and drive the actuator to expel the coalesced bubble from an outlet of the at least one fluid reservoir.

Abstract: Electronic modules for attachment to a drug delivery device include delivery status sensing means (21, 22) for monitoring a delivery status of the device, a status indicator (25) with an indicator element controllable to indicate a delivery or module status, and a status indicator controller (23), which generates an indicator control signal on behalf of the status indicator element, which in turn produces a status signal. The indicator control signal has an amplitude varying monotonically in time between a minimum value and a maximum value in a first interval of a base cycle, and between the maximum value and the minimum value in a second interval of the base cycle. In at least one of the first and the second interval, the mean value of the indicator control signal is below the average of the maximum and the minimum values of the indicator control signal to realize increased energy savings.

Abstract: Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

Abstract: A device for injecting a medicament is provided. The device has a housing with a container within it which can hold a medicament. At its proximal end the container has a needle and a stopper. The device includes a plunger which at one end can engage the stopper. At the opposite end, the plunger can engage a first resilient member to move the stopper within the container to inject the medicament from the container. The device includes a collar with distal and proximal ends, the distal end engaging with a carriage and causing its rotation and the proximal end engaging with a second resilient member. The second resilient member can engage with a skin sensor which has distal and proximal ends. At the proximal end, the skin sensor can contact an injection site. The housing has a cap which can reduce or prevent movement of the skin sensor.

Abstract: This application relates to an injector that can directly inject a solution containing biomolecules into a cell nucleus of a wide range of injection targets with high efficiency. In one aspect, the injector injects a solution containing biomolecules into an injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit and a nozzle unit, wherein the injector satisfies given conditions.

Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10).

Abstract: An electrohydraulic microjet drug delivery device includes: a discharge body provided with a power supply unit in which electric energy is stored; and a medicinal fluid delivery body detachably attached to the discharge body, the medicinal fluid delivery body including a pressure generation unit configured to store a pressure generation liquid, a medicinal fluid storage unit configured to store a medicinal fluid, an elastic separation membrane installed between the pressure generation unit and the medicinal fluid storage unit and configured to separate the pressure generation liquid and the medicinal fluid, a discharger installed inside the pressure generation unit so as to be submerged in the pressure generation liquid and configured to generate a spark using the electric energy stored in the power supply unit, and a nozzle kept in communication with the medicinal fluid storage unit, wherein when the spark is generated in the discharger, a part of the pressure generation liquid is vaporized and expanded to d

Abstract: The invention refers to a device for attachment to a portable liquid injection device, wherein said device is designed to enclose the drug reservoir of the injection device completely. Further, said device has at least one wave guide enabling a radio frequency wave to be applied along the drug reservoir of the injection device. In particular, the portable liquid injection device is a so-called insulin pen, i.e. a portable liquid injection device which is used to inject insulin for the treatment of diabetes. The inventive device preferably is in the form of a cap, in particular in the form of a cap of an insulin pen.

Abstract: A liquid delivery system cap device is provided. In some embodiments, an example cap device includes a body defining a cavity configured to receive at least a portion of a liquid delivery device, a first sensor configured to output a first sensor signal indicative of a plunger of the liquid delivery device, and a processor configured to detect a plunger of the liquid delivery device based on a variation in the sensor signal of the first sensor.

Abstract: A device includes a motor and a hollow drive shaft. The motor is configured to rotate the hollow drive shaft. A lead screw nut is operably connected to the hollow drive shaft. The lead screw nut is configured to rotate upon rotation of the hollow drive shaft. A lead screw is operably connected to the lead screw nut. The lead screw is configured to move within the lead screw nut and the lead screw is configured to pass through at least part of the hollow drive shaft.

Abstract: The invention provides a method for wirelessly communicating a dynamic data log from a data generating device using a transmit-only protocol is provided, the dynamic data log comprising at least one latest data entry, and a plurality of previous data entries. The method comprises the steps of continuously or intermittently transmitting the dynamic data log as a plurality of data packets, wherein the data packets comprise a prioritised packet populated by the at least one latest data entry, and a plurality of regular segment packets, each being populated with a subset of the plurality of previous data entries. The prioritised packet is transmitted more frequently than at least one of the regular segment packets.

Abstract: A medical injection system comprising an injection module, a retract module, and a bi-directional dose setting module. The bi-directional dose setting module comprises a dose plate, and the injection module comprises a dose knob engaged with the dose plate. The medical injection system generates a first response when the dose knob is rotated in the first direction, and generates a second response when the dose knob is rotated in the second direction.

Abstract: The present invention provides a drug delivery device with a dose counting mechanism and an end-of-content identification.

Abstract: A needle stick protection device includes a distal shield member having a slot which allows a needle to freely pass between shielded and unshielded positions an infinite number of times. The needle stick protection device also includes a proximal base member and a hinge connecting the distal shield member to the proximal base member. A locking mechanism secures the proximal base member to the distal shield member. The locking mechanism includes a compressive sleeve of the distal shield member and a distal cylindrical collar of the proximal base member, which frictionally fit together in a manner securing the proximal base member and the distal shield member.

Abstract: Systems for treating a targeted volume of muscle tissue to inhibit heterotopic ossification (HO) employ a delivery device including a reservoir containing a neuromuscular inhibitor and an injector assembly. The injector assembly can include an arrangement of needles and an injector operable to pass the neuromuscular inhibitor from the reservoir through the needles. The injector assembly can be configured to eject predetermined aliquots of a therapeutic dose of the neuromuscular inhibitor. The injector assembly can be shaped to compliment a targeted volume of muscle tissue within a larger volume of muscle tissue. The delivery of the aliquots can result in a therapeutic distribution of the therapeutic dose of neuromuscular inhibitor within the targeted volume of muscle tissue that is sufficient to prevent formation of an HO lesion but insufficient to induce paralysis of the larger volume of muscle tissue.

Abstract: In one embodiment, an infusion set and sensor assembly delivered within a subject is disclosed. The assembly includes a cannula that is terminated at a cannula opening. The assembly further includes a sharp that is at least partially within the hollow of the cannula. A sensor having a proximal end and a distal end is also included in the assembly. The proximal end of the sensor is held in a fixed location while the distal end is retained with a portion of the cannula. The sensor further includes sensor slack, wherein transitioning the sharp from a first position to a second position simultaneously inserts the cannula and sensor to a desired insertion depth within a subject via a single point of insertion.

Abstract: This application relates to an injector in which when a solution containing biomolecules is injected into an injection target, a proportion of biomolecules that function in the injection target with respect to the injected biomolecules is large. This application also relates to a method of injecting a solution containing biomolecules into an injection target using the injector. In one aspect, the injector injects the solution containing biomolecules into the injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit and a nozzle unit, wherein the injector satisfies a given condition.

Abstract: A medicinal oil delivery device includes a liquid medicinal oil storage reservoir that stores liquid medicinal oil; a heating element that converts the liquid medicinal oil into vaporous medicinal oil; a delivery device that delivers the liquid medicinal oil to the heating element; and a mouthpiece through which a user can receive the vaporous medicinal oil. The medicinal oil delivery device may include a body that includes the heating element and a removable cartridge engageable to the device that includes the liquid medicinal oil reservoir and mouthpiece.

Abstract: Some embodiments relate to a method for providing, during a single inhalation from an inhaler, a controllable ratio between at least a first active substance and a second active substance provided from the same source material, comprising: defining a ratio between the first and second active substances to be delivered to a user; setting operation parameters in accordance with the ratio, the operation parameters including at least one of a heating profile of the source material and an airflow profile through the source material; and operating the inhaler according to the operation parameters to deliver to the user, during a single inhalation, at least the first and second active substances at the defined ratio.

Abstract: An adapter for use in conjunction with a tracheostomy tube and/or its attachments is disclosed. It is adapted to complement conventional tracheostomy tubes and monitor and measure an assortment of breathing parameters, through one or more sensors, such as thermistors, microphones and the like. In order to evaluate whether there is a problem in the patient's airway (e.g., an obstruction), the data from the sensors is compared. By incorporating an alarm system as part of, or in conjunction with, the present invention, healthcare providers can be better able to quickly react to potential problems in the patient's airway.

Abstract: A nasal airway pressure monitoring system and method for use with neonatal patients is provided. The nasal airway pressure monitoring system has a nasal catheter, a pressure monitor, and a respiratory circuit supplying a respiratory gas. The nasal catheter is connected at a first end to the pressure monitor via a sample line and the second end of the nasal catheter is positioned in a nares. Upon delivery of gas flow through the patient respiratory circuit, the nasal catheter transmits pressure waveform data from the nasal airway to the pressure monitor. The pressure monitor processes the pressure waveform data. If the mean airway pressure is outside of a pre-set range of maximum and minimum limits, an alarm is triggered.

Abstract: A device including a mask configured to be placed over a nose and a mouth of a person, and a guide formed monolithically to the mask and extending distally therefrom. The mask is formed with an aperture extending into the guide as a passageway within the guide. The mask terminates distally at a lip, wherein the aperture is formed in the mask in front of the lip. The mask and the guide are formed by a common sidewall extending continuously from a proximal end of the device to a distal end of the device located behind the lip of the mask. The guide extends entirely from the mask to the distal end.

Abstract: A laryngeal mask airway includes: a guide tube that has one proximal end portion inserted into the larynx inside the trachea and the other distal end portion exposed to the outside of the trachea, guides the insertion of a flexible bronchoscope and an endotracheal tube inserted into the trachea, and is divided into left and right sides; a mask that is integrally connected to the one proximal end portion of the guide tube, prevents fluid and air from flowing into the larynx inside the trachea from the outside, and is divided into the left and right sides; a handle portion that is provided on the other side of the guide tube and protrudes to both sides of the guide tube to correspond to each other; and a coupling member that couples the guide tube and mask, which are divided into the left and right sides, to each other.

Abstract: A device includes a bite block and a guide formed monolithically thereto and extending distally therefrom. The bite block includes a retention structure at a proximal end of the device and a stub. The stub extends behind the retention structure and has a bite area which is sized to closely receive a mouth. The bite block and guide are formed by a common sidewall, extending continuously from a proximal end, at the retention structure, to an opposed distal end of the device.

Abstract: A nasal cannula comprising: a body portion, having a first end and a second end, the first and second ends being spaced apart from one another by the body portion; a body fluid inlet port formed at the first end, and a body fluid outlet port formed at the second end; and a first nasal inlet port and a first nasal output port each extending from the body portion of the cannula, the first nasal inlet port being in fluid communication with the body fluid outlet port, and the first nasal outlet port being in fluid communication with the body fluid inlet port, wherein the nasal cannula comprises first and second end caps at the first and second ends respectively, which first and second end caps are attachable to the body portion, and wherein the body fluid inlet port is formed in the first end cap, and the body fluid outlet port is formed in the second end cap.

Abstract: Described herein are various embodiments of an oxygen concentrator system and method of delivering oxygen enriched gas to a user. In some embodiments, oxygen concentrator system includes one or more components that improve the efficiency of oxygen enriched gas delivery during operation of the oxygen concentrator system.

Abstract: Apparatus for generating a supply of air at positive pressure for the amelioration or treatment of a respiratory disorder comprising a housing, a blower structured and configured to produce a flow of air at positive pressure, a flexible connector electrically and physically connected to the blower; and a blower rotation limitation structure configured to reduce rotation of the blower during use. The apparatus may comprise first and second blower suspensions for holding opposite ends of the blower. The blower suspension(s) may be flexible and in tension. The apparatus may comprise one or more connector anchors for anchoring a longitudinal middle section of the flexible connector to another part of the apparatus.

Abstract: In a pulmonary ventilation system, a filter arrangement useful as an input filter arrangement and an output filter arrangement is constructed to allow for changing or cleaning of the filter without interrupting or impacting the ventilation therapy and to limit the release of pathogens to the surrounding area or atmosphere. A preferred exhaust filter is constructed to function as a water trap and filter. Methods of operating the pulmonary ventilation system are also disclosed along with kits containing materials to construct an input or an output filtration structure.

Abstract: A reusable respirator including a mask adapted for covering and conforming to the face around the nose and a mouth of a user, a strap configured to secure the mask to a face of the user, and a filter component. All components of the respirator are capable of being cleaned, disinfected and sterilized at temperatures in excess of 50° C. An outer surface of the mask is substantially smooth and wettable for easily disinfecting and is shaped with a pair of outer shield portions for housing particulate air filters. The outer shield portions each include a closeable vent through the outer surface that is adapted to provide a user seal check and direct air flow through the outer surface for filtering by the respective particulate air filter, which is adapted to filter at least 95% of airborne particles.

Abstract: The present invention includes devices that relate to, for example, humidification systems for making humidified ventilator air that include a transparent or semi-transparent polymer-based heating element sleeve or sheet for the insulation of a tube delivering heated and humidified gas to a subject, comprising: a self-regulated heater and self-limiting heater, wherein the tubing is enveloped by the transparent heating sleeve, wherein the heating sleeve maintains at least one of: rates of relative humidity, absolute humidity and gas temperature, and wherein the heating sleeve envelops the tubing of inspiratory or expiratory limbs or ports connected to a mechanical ventilator providing gas to a subject.

Abstract: Respiratory diseases affect a large part of world population, especially in developing world. In this invention, we present a breathing support system to provide life-saving support to such patients. The system automates and regulates the use of a bag valve mask (commonly known as an ambu bag). The system uses mechanical actuators, sensors and a smart feedback control mechanism to automate and regulate the operation of the ambu bag to implement core functions of mechanical ventilation for life-saving applications. The system can also be used to provide better breathing support to newborns (e.g. to prevent hypoxia). The system can be used to save hundreds of thousands of lives in the developing world, in emergencies and during transportation globally.

Abstract: A device for training the muscles and connective tissue in the oral cavity and throat of a person, particularly for long-term avoidance of airway and sleep disorders and the consequences thereof, includes a wind instrument and furthermore an apparatus for detecting a sound produced by a person by the wind instrument. The device further includes an apparatus for evaluating the detected sound and an apparatus for outputting a response defined in dependence on a result of the evaluation to the person playing the wind instrument.

Abstract: Systems, devices and methods are provided for conducting a pain management therapy session, which includes performing a BCI training session utilizing feedback to train a subject to generate defined brain signals to assist the subject in managing and/or relieving pain, and applying a stimulus to the subject, in connection with the BCI training session, at a location that is near the source of pain and/or within the nervous system pain pathway to the source of pain.