Abstract: A method of determining a diameter of a sheath of an optic nerve includes obtaining, by a processor, scan data representative of the optic nerve sheath, analyzing, by the processor, the scan data to find a position of a globe-optic nerve interface point, segmenting, by the processor, the scan data, processing, by the processor, the segmented scan data at an offset from the position of the globe-optic nerve interface point to determine boundary positions of the optic nerve sheath, and calculating, by the processor, the diameter of the optic nerve sheath based on the determined boundary positions.

Abstract: The described embodiments relate to a self-regulating patch for taking biopotential measurements and balancing accurate measurements and user comfort. The self-regulating patch including: a heating element operable to generate heat that causes formation of sweat at the skin surface; a biopotential sensor; an exterior surface constructed of a moisture wicking material enveloping the heating element; and a logic to concurrently activate the biopotential sensor and transition the self-regulating patch between a plurality of modes, including a comfort mode and an accuracy mode, where in the comfort mode the heating element is inactive and in the accuracy mode the heating element is active.

Abstract: Systems and methods for determining an arrhythmia type are provided. A method may include: obtaining an electrocardiogram signal, obtaining a feature vector of the electrocardiogram signal, obtaining a trained prediction model, and determining an arrhythmia type of the electrocardiogram signal based on the trained prediction model and the feature vector. The feature vector includes a threshold crossing sample (TCSC) percent feature, an L-Z complexity feature, an empirical mode decomposition (EMD) complex number feature, a sample entropy feature, and a set of wavelet transform energy features.

Abstract: A capture catheter for sensing myocardial electrical signals is proposed, the capture catheter sensing the His bundle by sensing myocardial electrical signals and capturing a rope having passed through the His bundle. The capture catheter includes: a sheath catheter having a through hole formed therein; a myocardial sensing catheter inserted into the through hole of the sheath catheter to sense the His bundle; and at least one capturing device of which both ends are coupled to an outer circumferential surface of the myocardial sensing catheter to form an annular shape.

Abstract: A system for facilitating a cardiac rhythm disorder diagnosis with the aid of a digital computer is provided. A download station retrieves cutaneous action potentials of a patient by an ECG monitoring and recording device as ECG data. An R-R interval plot of the ECG data includes R-R intervals plotted along an x-axis of the plot and heart rates associated with the R-R intervals plotted along a y-axis of the plot. The R-R intervals are calculated as a difference between recording times of successive pairs of R-wave peaks and each heart rate is associated with each time difference. Runs of the R-R intervals in the plot are identified and each run represents a cardiac event. Cardiac rhythm measurements are automatically calculated and occurrences of different types of the cardiac events are tracked. One or more of the cardiac events and the cardiac rhythm measurements are reported.

Abstract: A sensor device measures bio-signals including one or more of electroencephalogram (EEG), heartbeat, electromyography (EMG), body temperature, body location, time, movement and velocity. The sensor device can include a circular fabric based headband with electrodes (conductive fabric sensing material) embedded therein, along with electronical circuitry and electrical wires. Electrodes can be positioned to make electrical contact with the scalp of a subject. For example, electroencephalography (EEG) measures the voltage changes resulting from ionic current with the neurons of the brain over a time period. By using multiple electrodes in contact with the scalp of the subject, neural oscillations can be detected in EEG measurements.

Abstract: Methods are disclosed for determining an efficacy of a stimulus based on one or more measurable physiological responses to one or more stimuli including one or more stimulus features. Data is acquired on physiological responses of a group of one or more subjects to presentation of one or more stimuli including one or more stimulus features. The data on the one or more physiological responses of the one or more subjects is correlated with the presentation of the one or more stimulus features included in the one or more stimuli. The correlated data on the one or more physiological responses are associated with a separately-determined efficacy of the one or more stimuli to form a stimulus efficacy model. From this information, a projected efficacy of a stimulus is determinable by comparing one or more subsequently-measured physiological responses to the stimulus with the stimulus efficacy model.

Abstract: This method for generating an indicator of the state of a patient in coma includes: generating at least one auditory stimulation by generating a sequence of auditory stimuli, the sequence producing evoked potentials in the patient; acquiring a first electroencephalographic signal produced by patient from at least one electrode; estimating at least one pair of values corresponding to a first parameter and a second parameter extracted from the first acquired signal, including estimating a first pair of values such that calculating the first parameter includes an estimation of the amplitude variance of the first signal within a predefined time window and the calculation of the second parameter includes an estimation of the correlation of two segments of the first signal; generating a state indicator for the or each pair of values of the first and second parameters, the values defining coordinates of a point in a reference base.

Abstract: In an apparatus for measuring biological information using a radio wave, a technique for acquiring an index related to a setting position of the apparatus with respect to a measurement site is provided. A biological information measurement apparatus (1) according to an aspect of the present disclosure includes a transmitter (3) configured to transmit a radio wave toward a measurement.

Abstract: The invention provides various methods for imaging a subject's cardiovascular system. The imaging methods may be used to diagnose or prognose various cardiovascular diseases in the subject, without contrast agents or radioactive tracers.

Abstract: A multi-modal bio-sensing apparatus is disclosed including a first sensor module comprising a photoplethysmogram (PPG) sensor configured to produce a first output representative of a blood volume of a human user, wherein the PPG sensor is configured to remove from the first output an error signal due to movement of a user; a second sensor module comprising an electroencephalogram (EEG) sensor configured to produce a third output representative of brain neural activity of the user; a third sensor module comprising an eye-gaze camera configured to capture a gaze direction of one or more eyes of the user; and a wireless communications transceiver coupled to receive sensor data from the first sensor module, the second sensor module, or the third sensor module and configured to wirelessly transmit the received sensor data from the first sensor module, the second sensor module, or the third sensor module out of the multi-modal bio-sensing apparatus.

Abstract: A breath analyzer for detecting breathing events of a person ventilated with a respiratory gas, comprising an electronic computing and storage unit configured to receive a signal corresponding to a ventilation pressure and/or a respiratory flow and/or a tidal volume of the respiratory gas delivered to the person and, during a predetermined analysis duration, to detect a curve of the signal by a curve analyzer. A ventilator for ventilating a person with a respiratory gas, which ventilator comprises the breath analyzer and a method for detecting breathing events of a person ventilated with a respiratory gas is also described.

Abstract: Measurement of airway resistance and/or lung compliance during non forced exhalation is performed using initial occlusion of exhalation followed by removal of the occlusion or opening of a shutter. The measurement device can use a single sensor to measure both pressure and flow. A pressure monitor can detect that exhalation is improperly forced to signal an error or to reject a pressure and flow measurement from a forced exhalation trial.

Abstract: There is provided a computer-implemented device comprising a processor, a machine readable medium storing instructions, the instructions when executed by the processor for configuring the device for: receiving an airflow and volume signal from at least one airflow and volume sensor for a plurality of patients; digitizing the signal to a digital signal and segmenting the signal using a sliding window to extract a plurality of features from the digital signal comprising: peak-to-peak amplitude, root mean square, integral of the absolute values, zero-crossing rate, standard deviation of a first derivative, mean value; normalizing the plurality of extracted features; and, using the normalized plurality of extracted features and an input indicating sleep apnea severity to train a machine learning algorithm and generate a mathematical model for subsequent use in classifying airflow and volume sensed signals received for a particular patient during wakefulness as normal or sleep apnea.

Abstract: An indicator device represents a measured value and includes a first component and a second component. The first component includes a machine-readable first reference marker, a machine-readable second reference marker spaced from the first reference marker and a guide for the second component. The first reference marker defines a first reference point and the second reference marker defines a second reference point. The position and orientation of a predetermined path are defined by the first reference point and the second reference point. The second component can be positioned along the guide by a displacement force. The second component alone, or together with the first component, forms a machine-readable value indicator. The measured value is represented by a position of the value indicator along the predetermined path. The disclosure also relates to a measuring apparatus comprising the indicator device.

Abstract: A system for urine analysis and personal health monitoring includes a testing box, including a testing chamber, a camera aperture, a visual check aperture, and a test slot, an interchangeable color pattern chart, including a bar code, a base color calibration strip, a test result area, and a test lookup area; a diagnostic analysis server, and a diagnostic analysis device, including a processor, a diagnostic manager, a camera manager, an image analyzer, a camera calibrator, and a camera; such that the diagnostic analysis device captures an original image of the testing chamber interior with a test strip inserted, and analyzes a diagnostic portion of the original image and calculates a test result. Also disclosed is a method for diagnostic analysis, including installing interchangeable color pattern chart, depositing sample, inserting test strip, capturing image, performing color calibration, reading bar code, extracting test strip image, performing color conversion, and calculating test result.

Abstract: A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. An evoked stimulation response may be sensed by a sensor near a portion of a subject. The evoked response may be sensed by an electrode and determined with a monitoring system. The evoked response may additionally and/or alternatively be sensed with a motion sensor. A position sensor may be provided to measure or determine whether the sensor has moved during a procedure.

Abstract: A wearable, secure medical-record storage and management USB/Micro USB bracelet provided together with systems and methods for inputting, managing and updating records contained in such a device. Additionally provided are GPS system for locating the user, pulse monitor for detecting the users pulse, high impact sensor in case of a car accident, or fall, or in case the user is unconscious, which can alert emergency assistance and relay information in emergency situations. Access to the contents of the medical record storage and management USB/Micro USB bracelet is controlled using encrypted software as well as other means for authentication.

Abstract: A smart monitoring system comprising a plurality of sensor devices coupled to appliances and fixtures within a dwelling environment, where at least one of the plurality of sensor devices comprises sensor elements including an accelerometer. The system further comprising a computing device operative to receive event signals from the plurality of sensor devices, identify a possible fall event from one or more of the plurality of sensor devices based on the event signals, sample sensor data from one or more of the plurality of sensor devices wherein the sensor data includes measurements of movement. The computer device is further operative to determine a fall has occurred based on the sampled sensor data, sample additional sensor data from the one or more of the plurality of sensor devices for additional motion at a period of time subsequent to the possible fall event, and determine a recovery from the fall based on the additional sensor data.

Abstract: An electrochemical probe for in-vivo measurement of H2O2 oxidation within a living tissue. The electrochemical probe includes a sensing part and a handle. The sensing part includes a working electrode including a first biocompatible conductive needle, a counter electrode including a second biocompatible conductive needle, and a reference electrode including a third biocompatible conductive needle. The working electrode, the counter electrode, and the reference electrode are configured to put in contact with the living tissue by inserting the sensing part into the living tissue. The handle includes an insertion part that may be configured to insert the sensing part into the living tissue. The sensing part is attached to the insertion part.

Abstract: A device for biofluid processing and analysis includes a microfluidic module including multiple stacked layers, each layer of the stacked layers defines a respective conduit, and conduits of the stacked layers are interconnected to provide a flow path for a biofluid.

Abstract: Enzymatic and non-enzymatic detectors and associated membrane apparatus, and methods of use, such as within a fully implantable sensor apparatus. In one embodiment, detector performance is controlled through selective use of membrane configurations and enzyme region shapes, which enable accurate detection of blood glucose level within the solid tissue of the living host for extended periods of time. Isolation between the host's tissue and the underlying enzymes and reaction byproducts used in the detectors is also advantageously maintained in one embodiment via use of a non-enzyme containing permeable membrane formed of e.g., a biocompatible crosslinked protein-based material. Control of response range and/or rate in some embodiments also permits customization of sensor elements. In one variant, heterogeneous detector elements are used to, e.g., accommodate a wider range of blood glucose concentration within the host.

Abstract: Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices.

Abstract: An apparatus for performing phlebotomy through a peripheral intravenous line. The apparatus includes an introducer and a catheter configured to advance the catheter through a peripheral intravenous line. A y-adapter with a port of larger diameter is configured to receive the catheter and place in fluid communication with the peripheral intravenous line. When advanced the catheter is configured to transport a bodily fluid (i.e. blood) to a volume outside of the body.

Abstract: Recognizing mental states from physiological signal is a concern not only for medical diagnostics, but also for cognitive science, behavioral studies as well as brain machine interfaces. Embodiments of the present disclosure utilize respiration signals to decipher mental states wherein non-linear baseline drifts in signal is implemented to extract the respiratory features in most effective way. Presence of class imbalance, is effectively rectified using Synthetic Minority Oversampling Technique (SMOTE) to resolve class imbalance problem, which not only increased the classification accuracy, but also reduced classifier bias towards the majority class, which in turn exceedingly enhanced the classifier sensitivity.

Abstract: Behavioral and mental health therapy systems in accordance with several embodiments of the invention include a wearable camera and/or a variety of sensors (accelerometer, microphone, among various other) connected to a computing system including a display, audio output, holographic output, and/or vibrotactile output to automatically recognize social cues from images captured by at least one camera and provide this information to the wearer via one or more outputs such as (but not limited to) displaying an image, displaying a holographic overlay, generating an audible signal, and/or generating a vibration.

Abstract: The present invention provides systems and methods for testing and assessing preference (e.g., taste preference). In one aspect, various aspects of an individuals taste preferences (e.g., degree an individual likes/dislikes a taste ingredient, degree an individual is willing to pay to keep/exclude a taste ingredient) are tested and assessed. In a further aspect, the taste preferences of a plurality of individuals are tested, assessed, and compared and, optionally, individuals are rewarded for their taste preference(s). Apparatus, computer readable media and systems for implementing the taste preference assessment and provision of rewards are also provided.

Abstract: A wearable device comprising a data logger, a motion sensor, and a memory component is disclosed for recording motion data. The motion sensor may detect movement of the device when worn by a subject, and the memory component may store motion data from the motion sensor. A casing may be included for retaining the data logger and providing a contact barrier between at least part of the data logger and the subject. The contact barrier may substantially prevent contact contamination of at least part of the data logger while the device is worn by the subject for collection and storage of subject-specific motion data. The casing is controllably accessible to release the data logger in a substantially uncontaminated state.

Abstract: The present disclosure provides systems and methods for collecting and analyzing vital sign information to predict a likelihood of a subject having a disease or disorder. In an aspect, a system for monitoring a subject may comprise: sensors comprising an electrocardiogram (ECG) sensor, which sensors are configured to acquire health data comprising vital sign measurements of the subject over a period of time; and a mobile electronic device, comprising: an electronic display; a wireless transceiver; and one or more computer processors configured to (i) receive the health data from the sensors through the wireless transceiver, (ii) process the health data using a trained algorithm to generate an output indicative of a progression or regression of a health condition of the subject over the period of time at a sensitivity of at least about 80%, and (iii) provide the output for display to the subject on the electronic display.

Abstract: A menstrual cycle monitoring system can be used to monitor fertility. The menstrual cycle monitoring system can comprise an intravaginal body which includes a hydration sensing probe(s) and/or sensor(s) and a temperature sensor oriented to measure bioelectrical impedance, resistance and/or conductance within cervical mucus and/or the vaginal environment and basal body temperature, respectively. A data communication unit stores and optionally transmits collected fertility data which includes at least the measured bioelectrical impedance, resistance and/or conductance and temperature over time. A power source can be electrically coupled to the hydration sensing probe(s) and/or sensor(s), temperature sensor and the data communication unit.

Abstract: The present invention provides an electronic device and a method for providing content according to the skin type of a user. The electronic devices according to various embodiments comprise: a display; and a processor, wherein the processor obtains skin diagnosis information which represents the skin condition of a user, determines the skin type of the user on the basis of skin diagnosis information, and displays, on the display, information on the determined skin type and content corresponding to the determined skin type. Other embodiments are also available.

Abstract: A device may obtain absorption spectra data associated with tissue of a subject. The device may determine, based on the absorption spectra data, an estimate of a water content associated with the tissue. The device may determine, based on the estimate of the water content, an estimate of a hydration level of the subject. The device may perform one or more actions based on the estimate of the hydration level of the subject.

Abstract: A method of identifying a subdermal feature in a subject includes directing optical energy into a subject to photoacoustically generate ultrasonic waves from a dermal or subdermal feature in tissue. Signals representing ultrasonic waves that are generated from the dermal or subdermal feature are received. The signals representing the ultrasonic waves are processed to generate image data of the dermal or subdermal feature. It is determined from the image data that the dermal or subdermal feature is a non-healing skin lesion selected from the group including a pressure ulcer, a diabetic foot ulcer, an arterial insufficiency injury, a decubitus ulcer, a diabetic ulcer, and an insufficiency injury.

Abstract: A finger insert for use with a nailfold imaging device includes a housing to receive the user's finger and an immersion substance (e.g., immersion oil), and a deformable pad that holds the user's finger in place during imaging, as well as prevent bubble formation in the substance. The housing includes a transparent wall to facilitate imaging of the finger. The transparent wall includes multiple angled portions that prevent or reduce contact between the nailfold and the wall, to ensure sufficient blood flow through the nailfold region for imaging.

Abstract: A foot sensor feedback device with multiple passive sensors in a shoe insole to provide real time feedback for a microprocessor to control a haptic device on the ankle of a person and to store and display data on an application on a smart phone to provide balance to a person while standing still or walking.

Abstract: A pressure sensor is configured to generate pressure readings from a user that is sleeping on a bladder. A client unit is configured to receive the pressure readings from the pressure sensor for a plurality of night's sleep for the user and transmit sleep-data to a cloud unit that is geographically remote from the client unit. A cloud unit is configured to receive the sleep-data, generate report-data from the sleep data; and generate sleep-reports for the user, each report corresponding to at least one different night's sleep of the user.

Abstract: Provided herein is a system or method for biofeedback for gait training in a subject in need thereof, involving sensors capable of being put on the thigh, shank and heel of the subject, and two separate output displays shows knee flexion data and knee extension data in real-time.

Abstract: A vital-sign detection system is provided. The vital-sign detection system includes a vital-sign detection device and a controller. The vital-sign detection device is enabled to detect a vital-sign of a user. The controller determines whether the gets in the bed and controls the vital-sign detection device to switch to a disabled mode from a first enabled mode in response to the user getting in the bed. During a period when the vital-sign detection device is in the disabled mode, the controller determines whether the user falls asleep. In response to the user falling asleep, the controller controls the vital-sign detection device to switch to a second enabled mode from the disabled mode.

Abstract: Systems and methods for sleep stage determination are disclosed. Example systems disclosed herein includes a complexity module operable to measure the complexity of regularities in an EEG channel, and a stager operable to output at least one corresponding sleep stage. Some example systems also include monitoring a subject, and determine the subject may have impairment, Alzheimer's disease, or anesthesia problem that is associated with sleep staging problem.

Abstract: In some examples, a method including determining an effective brain age metric for a patient based on at least one brain signal of the patient; receiving a signal indicative of a physiological parameter of the patient; and generating an index score indicative of depth of anesthesia (DOA) of the patient based on the received signal and the determined effective brain age metric for the patient.

Abstract: A compliance monitoring system (40) for an intraoral appliance comprises a power source (460), a detector (410) for detecting when the intraoral appliance is positioned in the mouth for use, a recorder (430) configured to record measurement data, and a transponder (440) configured to communicate the measurement data. The monitoring system is adjustable based on a particular property of a patient or a group of patients.

Abstract: An exemplary breath analysis system may include a sampling chamber having a molecule collector disposed therein. The molecule detector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A heating element may introduce heat within the sampling chamber, causing release of at least a portion of the VOCs adhered to the molecule collector. An analysis device (e.g., a mass spectrometer or tetrahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified one or more target VOCs. The output may include information that quantitates a concentration of the one or more target VOCs with respect to a source of the breath sample.

Abstract: Provided is a biological information measuring instrument which can be easily and reliably worn on an appropriate position of an arm by a user. The biological information measuring instrument includes: a belt portion that is worn on a user's arm in a circumferential direction of the arm and disposed with a sensor for detecting a displacement of an arm muscle; and a case portion that is attached to a predetermined portion of the belt portion and houses a circuit component that processes a signal of the displacement detected by the sensor. The case portion has a shape of protruding from the belt portion in a longitudinal direction of the arm when the belt portion is worn on the arm, and amounts D1 and D2 of protrusions protruding in the longitudinal direction are different between one protrusion and the other protrusion.

Abstract: This invention generally relates to methods useful for measuring heart rate, respiration conditions, and oxygen saturation and a wearable device that incorporate those methods with a computerized system supporting data collection, analysis, readout and sharing. Particularly this present invention relates to a wearable device, such as a wristwatch or ring, for real time measuring heart rate, respiration conditions, and oxygen saturation.

Abstract: Monitoring devices and monitoring technology are disclosed for a number of applications. A monitoring device that attaches to a measurement site includes at least one of an optical sensor, a temperature sensor, or first and second electrical contact sensors. A monitoring device or a smart garment can be powered by one or more bio-batteries that is each formed by electrodes in contact with the user's body (e.g., skin) or an animal. Various method and algorithms can be used to process signals received from the optical sensor, a temperature sensor, and/or first and second electrical contact sensors. The signals received from the optical sensor, a temperature sensor, and/or first and second electrical contact sensors can be transmitted to a host device. An application program on a host device can process the signals to compute one or more physiological parameters, waveform data, trend data, and/or one or more reports.

Abstract: An apparatus for estimating bio-information is provided. The apparatus for estimating bio-information may include: a pulse wave sensor configured to measure a pulse wave signal from an object; a force sensor configured to measure a force exerted by the object to the pulse wave sensor; and a processor configured to obtain a contact pressure based on the force and a reference contact area between the object and a contact surface, and estimate bio-information based on the contact pressure and the pulse wave signal.

Abstract: Personal health monitoring devices and methods are disclosed. A health monitoring device includes a sensor unit including a source and receiver of optical energy, a housing configured to receive and house the sensor unit, and a coupling mechanism configured to couple the housing to a band to be worn at least partially about one of a wrist or a lower forearm of a wearer of the band. The coupling mechanism is further configured to position the housing pointing the sensor unit inward to the wrist or lower forearm of the wearer with an inward radial force on the sensor unit based on tension in the band. The health monitoring device also includes a data storage device and a processor configured to receive, from the sensor unit, data about received optical energy, and to produce photoplethysmogram data using the received data, and to store data to the data storage device.

Abstract: A sensor device (2) is disclosed. The sensor device (2) comprises a processor (14), a memory (24), an antenna (6), a power source (e.g. a battery), one or more sensing elements (12) configured to provide measurement data and store the measurement data in the memory (24) and a communication unit (16) configured to transfer data from the one or more sensing elements (12) and data stored in the memory to a remote unit (28). The sensor device (2) comprises a contact detection unit configured to detect if the sensor device (2) is in contact with or in close proximity to the skin (80) of a user (32, 32?) if at least two of the at least three measurements made by different sensing elements (12) indicate that the sensor device (2) is in contact with or in close proximity to the skin (80) of a user (32, 32?).

Abstract: An optoacoustic probe for optoacoustic imaging of a volume, the optoacoustic probe having a distal end operable to contact the volume and a proximal end. The optoacoustic probe includes at least one primary light source and an auxiliary light source that is configured to generate auxiliary light carried through an optical window to a volume. A detection device is configured to detect signals generated from the auxiliary light or primary light reflecting from the volume or the optical window. A microcontroller including one or more processors is also provided, that receives the signals generated from the auxiliary light reflecting from the volume from the detection device, determines contact between the volume and the optoacoustic probe based on the auxiliary light reflecting from the volume, and prevents the at least one primary light source from generating light until the optoacoustic probe is contacting the volume.