Abstract: Microspheres made of solid glass are used in radiation therapy, wherein the radiotherapeutic radionuclide must be generated in the glass by neutron activation. Microspheres of this type have a high radioactive load, are relatively heavy and contain additional non-therapeutic radionuclides. Additionally, radioactive microspheres made of plastic are used, which can be loaded with radionuclides by chemical means. These microspheres have a lower loading capacity, no additional radionuclides, and are lighter. The therapeutic radionuclide in both cases is Y-90. Microspheres made of nanoporous glass contain the therapeutic radionuclide, have a high loading capacity, require no neutron activation, can be parallel charged with multiple therapeutic and with diagnostic radionuclides, and are very light. It is possible to produce them in a radiochemical laboratory. Microspheres of this type can also be used diagnostically in preparation for therapy.

Abstract: A standalone UV-C sanitizing apparatus and method is provided that is operable to sanitize and disinfect a user's hands or protective gloves. The apparatus includes a housing with light emitting diodes (LEDs) positioned to emit ultraviolet (UV-C) light connected to a circuit board which are individually connected to a power source. The apparatus is configured so that when the user positions the hands or gloves under the housing, the UV-C light is emitted for a predetermined period of time based on the distance to the hands and the power output of the LEDs. The UV-C light is emitted at a wavelength suitable to kill, destroy, or reduce growth of microorganisms/germs. The housing can be configured with a sensor to detect motion under the housing and include a limiter hand guard.

Abstract: An ultrasound imaging system (100) including a disinfection system is disclosed. The disinfection system may include one or more ultraviolet light sources (115). The UV light sources may be included in a display (105). The disinfection system may be configured to operate when the display is parallel to a control panel (120) of the ultrasound imaging system. The disinfection system may provide indications of the disinfection status of the ultrasound imaging system.

Abstract: The present disclosure is generally related to devices, methods and systems for cleaning, disinfecting and/or sterilizing a medical device, medical hoses and tubes and accessories thereof with ozone gas, in particular the disclosure relates to devices, methods and systems with multiple receptacles for providing closed-loop fluid pathways to distribute ozone gas to inner passageways and the outer compartments of medical devices. The devices in accordance with an embodiment of the disclosure have two or more receptacles for distributing ozone gas, a gas-tight compartment, an ozone operating system, and one or more connector units configured to fluidly migrate ozone in closed-loop treatment systems.

Abstract: The present invention relates to methods and devices for providing microbial control and/or disinfection/remediation of an environment. The methods generally comprise: generating a Purified Hydrogen Peroxide Gas (PHPG) that is substantially free of, e.g., hydration, ozone, plasma species, and/or organic species; and directing the gas comprising primarily PHPG into the environment such that the PHPG acts to provide microbial control and/or disinfection/remediation in the environment, preferably both on surfaces and in the air.

Abstract: A container system includes a container or a sterile container to which an attachment part can be fastened. For this purpose, the sterile container has a fastening portion which is formed integrally with or integrally in a closed container wall of the container, to which the attachment part can be fastened in a positive fit or locked in a spring-elastic manner.

Abstract: Sterilization packaging systems with features for sealing a volume against an ingress of contaminants are provided. Such features include a sealing assembly including a gasket and a sheet of filter material. The sealing assembly seals a lid to a seal rim of a base. The gasket has an upper surface, outer edge, and inner edge. The upper surface of the gasket comprises a first row of alternating protrusions and indentations and a second row of alternating protrusions and indentations that define a channel therebetween. The sheet of filter material extends from an inner edge of the gasket. The gasket completely surrounds the sheet of filter material, wherein the indentations and channel facilitate delivery of a sterilization agent through the filter material. A sterilization assembly including a lid having a plurality of protrusions in its upper surface in conjunction with a gasket having a smooth upper surface is also provided.

Abstract: A dispenser includes a housing having a cavity. A container is provided within the cavity and includes a volatile material therein. The dispenser further includes a resistive heating wire. The container is in thermal communication with at least a portion of the resistive heating wire.

Abstract: The invention relates to an evaporation device for evaporating volatile substances, comprising a container (1) housing a liquid (8) containing the volatile substances, an outlet (2) through which the volatile substances exit and a hole (9) for equalizing the pressure between the inside and the outside of the container, and characterized in that it also comprises a membrane (6) placed between the container (1) and the hole (9), said membrane (6) being leak-tight with respect to said liquid (8) and porous with respect to the gases. This membrane prevents the liquid from accidentally spilling and furthermore solves the issue of balancing pressures inside the container, keeping the rate of evaporation constant until running out of the volatile substances.

Abstract: Aqueous compositions, methods of manufacturing such aqueous compositions, and methods of removing reducing and/or suppressing malodours using such aqueous compositions are described. These compositions utilize a combination of hydrogen peroxide, a source of copper II, nonionic surfactant and alcohol to provide a highly effective and stable malodour removing, reducing and/or suppressing composition. The compositions are particularly useful as aerosol compositions for effective malodour removal, reduction and/or suppression in particular malodours from open sites such as landfill and in closed domestic environments such as the home. Also described is a stabilized hydrogen peroxide solution, which is stable on the addition of copper (II) salts.

Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-?m-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-?m-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.

Abstract: This invention relates to a hemostatic member using chitosan having superior hemostatic activity, and more particularly to a chitosan-based hemostatic member for the cervix, suitable for use through insertion into an affected part upon cervical biopsy or surgery, configured to include a hemostatic pack having a projection at an upper end thereof through tying with a thread so as to form a spherical shape using chitosan nonwoven fabrics having a hemostatic function, wherein the thread contains an X-ray-sensitive material, thereby realizing effective hemostasis of the affected part upon cervical biopsy or surgery.

Abstract: Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.

Abstract: An adhesive composition is intended to provide the attaching to human skin, comprising a continuous phase and a discontinuous phase of hydrocolloids, with the continuous phase comprising by weight, based on the total weight of the adhesive composition: (i) 1 to 12% by weight of a sequenced polymer of the styrene-isoprene-styrene or styrene-butadiene-styrene type, (ii) (a) 1 to 15% of a polymer of the elastomer butyl type, possibly as a mixture with up to 25% by weight of a polymer of the polyisobutylene type, or (b) more than 10% to 30% of a polymer of the polyisobutylene type, free of polymer of the elastomer butyl type, (iii) 1 to less than 10% of a polymer of the ethylene vinyl acetate type, with the sum of these three types of polymers representing from 10 to 40%.

Abstract: Provided is a method of forming a fibrinogen hydrogel composition, the method including providing a fibrinogen hydrogel or precursor thereof, comprising fibrinogen hydrogel forming salt. The fibrinogen hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrinogen hydrogel. The method further includes denaturing the fibrinogen hydrogel such as by heating. The method optionally further includes combining the fibrinogen hydrogel with a carrier material. When present, the concentration of the carrier material typically ranges from 0.1 to about 50 wt.-%. The method further includes reducing the salt concentration below the threshold concentration to form a fibrinogen hydrogel.

Abstract: Provided is an antibacterial biological implant capable of exhibiting superior antibacterial activity stably over a long period of time. Also provided is a method for producing an antibacterial biological implant, the method including subjecting a substrate 2 successively to an anodization treatment, an acid treatment, and an iodine treatment to obtain an antibacterial biological implant 1.

Abstract: A biocompatible nerve conduit for nerve re-generation, wherein a porous fiber tube is coated with a bioresorbable hydrogel, with the fibers being formed from a polymer that supports nerve regeneration by preferential adsorption of endogenous proteins and braided with pores in the range from 5 to 200 micrometers using a kink-resistant braiding pattern and the hydro gel coating material and thickness being selected to control the overall porosity, so that nutrients and oxygen can diffuse through said hydrogel coating but the infiltration of fibrous tissue through the coating is prevented.

Abstract: A synthetic composite material for tissue repair is disclosed which includes a first layer having an organic material and having side walls and external surface; and a second porous layer comprising an inorganic material and having side walls; wherein the first layer is in direct contact with the second layer and wherein the side walls of the first layer and the side walls of the second layer are coated with a third layer of the organic material.

Abstract: A method of forming a scaffold comprises the steps of: preparing a high internal phase emulsion (HIPE) comprising an aqueous solution of: proteins selected from the group consisting of collagen and mixtures of collagen and chitosan; and a cross-linking agent; by addition of an immiscible solvent to the solution to form the HIPE; reducing the temperature of the HIPE to solidify the HIPE; removing water and solvent by vaporisation at a temperature above the melting point of the solvent to form a porous structure; and before or after removal of solvent, causing cross-linking of the protein with the cross-linking agent to form a crosslinked scaffold structure.

Abstract: A scaffold is provided, the scaffold comprising: at least one inlet tube; at least one outlet tube; and a plurality of porous elongated microtubes, wherein each one of said porous elongated microtube has an inner diameter of 5-100 micrometers, wherein said plurality of elongated microtubes extend from said at least one inlet tube to said at least one outlet tube and is in fluid communication thereto, Further provided is a method for producing and using the scaffold, such as for tissue engineering.

Abstract: Provided herein is a method of making an aligned ECM scaffold useful in refractive correction of the eye and repair of the cornea. Methods of use of the scaffold as well as a scaffold construct are provided.

Abstract: Various embodiments relate to catheter locking solutions and catheter locking therapies with use of trisodium citrate and ethyl alcohol, and in particular 4.0 to 15.0 weight/volume % trisodium citrate as an anticoagulant component and/or an antibacterial component and 15.0 to 25.0 volume/volume % ethyl alcohol as an antibacterial component. Use of the catheter locking solution and catheter locking therapy can reduce treatment failure during medical procedures that may employ catheters to supply treatment by at least significantly reducing the risks associated with bloodstream infections, catheter system malfunction, emboli formation, patient discomfort, and patient illness. These benefits can be partially due to the synergistic antibacterial effects of the trisodium citrate and ethyl alcohol in solution, generating an effective catheter locking solution with minimal concentrations of ethyl alcohol.

Abstract: Methods are provided for promoting cartilage growth and/or repair. The methods include, administering locally to a site in a subject in need thereof, bone marrow stromal cells attached to fibrin microbeads comprising crosslinked hyaluronic acid and thereby producing stable cartilage locally at the site in the subject.

Abstract: A medical waste fluid collection cart may include a container assembly and a suction tube having a lumen extending through the suction tube. The suction tube may communicate with the container to deposit waste fluid from a surgical site in the container. The container assembly may include a container, a base forming a bottom of the container, and a lid assembly. The base may include an interior surface defining a draining opening. The interior surface may extend along a ramped path toward the drain opening. The lid assembly may include a lid ring and a lid capable of engaging each other with a twist lock mechanism. The lid ring may engage the container and the lid may cover at least part of a central opening to the container. The container may have a window and a tinting assembly. The container assembly may have a vacuum level detection system.

Abstract: Systems and methods are presented for providing reduced pressure to and monitoring pressure at a plurality of tissue sites using a plurality of pressure management devices. The pressure management devices are associated with a plurality of sensing conduits that fluidly couple the pressure management devices and the plurality of tissue sites. Other systems, methods, and devices are disclosed.

Abstract: A method and apparatus for injecting a saline solution into an open cavity of a patient's body, and, alternatively, vacuuming fluids from the open cavity during laparoscopic surgery that provides constant feed and amplified pressure to provide a steady fluid output, in a disposable, single use handheld surgical device.

Abstract: A system, method and apparatus for notifying a surgeon of an occlusion in an ocular surgical apparatus are disclosed herein. Through operation of a handpiece of the surgical apparatus, the handpiece may become blocked or occluded. An occlusion detector is configured to sense the occlusion in the handpiece, and an occlusion signal is generated. A control module is provided to send an occlusion warning signal to a foot pedal of the surgical apparatus, where a tactile notification is provided to a user of the apparatus that an occlusion has occurred.

Abstract: A system, method and apparatus for notifying a surgeon of an occlusion in an ocular surgical apparatus are disclosed herein. Through operation of a handpiece of the surgical apparatus, the handpiece may become blocked or occluded. An occlusion detector is configured to sense the occlusion in the handpiece, and an occlusion signal is generated. A control module is provided to send an occlusion warning signal to a foot pedal of the surgical apparatus, where a tactile notification is provided to a user of the apparatus that an occlusion has occurred.

Abstract: A surgical collection assembly for filtering material from liquid obtained during surgery. A jar having an inlet and an outlet each adapted for connection to a suction line. A set of orientation features to position an upper portion of a collection basket within the jar such that an upper portion of the collection basket does not impede a flow of material entering the jar through the inlet. A bottom surface with a pattern of recessed paths in the bottom surface, the pattern of recessed paths connected to the outlet. A plunger assembly that may be reversibly attached to the jar so that a distal end of a plunger may be used to compress collected material within the collection basket to help remove fluid from the collected material. For certain uses, the surgical collection assembly may have a simple jar lid without an integrated plunger.

Abstract: A method of recovering white blood cells from a leukoreduction filter, the method comprising providing a solution comprising a sugar, flowing a volume of the solution through a leukoreduction filter containing captured white blood cells, and collecting elute from the leukoreduction filter, wherein the elute comprises the solution and recovered white blood cells.

Abstract: Methods and systems for reducing bacterial contamination of platelets are disclosed. The methods and systems disclosed herein provide for the processing of a pre-determined volume of whole blood so as to reduce the risk that platelets separated and collected from the whole blood have a reduced risk of bacterial contamination.

Abstract: A control circuit for controlling a supply of power to an external electronics module for controlling an implanted device of the user, the control circuit electrically coupled to a switching circuit for controlling an electrical connection between an external power source, a battery, and an external electronics module, the control circuit further electrically coupled to a sensor for sensing at least one from the group consisting of a voltage and a current received from the external power source, the control circuit being configured to control the switching circuit to electrically disconnect the external electronics module from the external power source and electrically connect the external electronics module to the battery in response to a sensed fluctuation of at least one from the group consisting of voltage and current and electrically connect the external electronics module to the external power source and electrically disconnect the external electronics module from the battery when the fluctuation is not

Abstract: Systems and devices for improving wireless power transmission are disclosed herein. The system can include an implantable medical device that can include an energy storage component and a secondary coil electrically coupled to the energy storage component. The system can include a charging device. The charging device can include a flexible housing defining an internal volume, a resonant circuit, a plurality of sensors coupled to the primary coil, and processor. The resonant circuit can include a deformable primary coil located within the internal volume of the housing. The processor can determine a deformation of the primary coil based on at least one signal received from at least one of the plurality of sensors.

Abstract: A blood purification apparatus with an arterial puncture needle or a venous puncture needle is stuck in the patient can be easily notified at the activation of a blood pump in an unconnected step. A blood purification apparatus includes a blood circuit for circulating blood, a dialyzer capable of purifying the blood, a blood pump provided to an arterial blood circuit for delivering a liquid, and a control device that executes a connected step in which the blood pump is activated when an arterial puncture needle (a) and a venous puncture needle (b) are in the patient and an unconnected step in which the blood pump is activated with neither the arterial puncture needle (a) nor the venous puncture needle (b) being stuck in the patient. The control device establishes, in the unconnected step, a restricted state where the behavior of the blood pump at the activation of the blood pump is restricted.

Abstract: A blood purification apparatus where neither an arterial puncture needle nor a venous puncture needle is stuck in the patient can be checked automatically when it is attempted to activate a blood pump in an unconnected step. A blood purification apparatus includes a blood circuit for circulating blood, a dialyzer for purifying the blood, a blood pump provided to an arterial blood circuit for delivering liquid when activated, and a control device that executes a connected step when blood pump is activated with an arterial puncture needle (a) and a venous puncture needle (b) being stuck in the patient and an unconnected step in which the blood pump is activated with neither the arterial puncture needle (a) nor the venous puncture needle (b) being stuck in the patient.

Abstract: The invention relates to an apparatus for extracorporeal blood treatment that comprises a device 1 for providing fresh dialysate and a drain 2 for used dialysate, a balancing device 4 for balancing fresh dialysate and used dialysate, an ultrafiltration device 15, and a dialyser 3 that is divided into a blood chamber 6 and a dialysate chamber 7 by a semi-permeable membrane 5. The invention further relates to a method for operating such an apparatus for extracorporeal blood treatment. The apparatus according to the invention is based on the use of the ultrafiltration device 15 of the blood treatment apparatus for raising the liquid level in the air separation device 12 on the secondary side of the dialysate system I. In the apparatus according to the invention, the ultrafiltration device 15 is designed such that the ultrafiltration device can be operated not only in an ultrafiltration mode, but also in a ventilation mode.

Abstract: The present invention relates to a method for preparing a medical solution from at least one first liquid component and at least one second liquid component, wherein the first component and the second component are conveyed with a respective conveying means to obtain a mixed solution, wherein the conveying means are operated such that a modulation of the concentration of the first and second components takes place and the conductivity or a parameter of the mixed solution correlating with the conductivity is measured at a measurement point, wherein the modulation of the concentrations takes place in a desired state such that no modulation or a specific desired modulation of the measured conductivity or of the parameter correlated with the conductivity occurs. The present invention furthermore relates to an apparatus for preparing a medical solution as well as to a blood treatment device having such an apparatus.

Abstract: A dialysis system comprises a filtration means, a pump and a sorbent device for performing a dialysis treatment and/or for regenerating a dialysate solution.

Abstract: Systems and methods for monitoring oxygenator performance in extracorporeal circuit systems or the like. More particularly, the disclosure relates to systems and methods including a controller programmed to determine oxygenator apparatus flow impedance as a function of an inlet pressure measurement, an outlet pressure measurement and a blood flow rate measurement. The systems and methods may include a communication device that receives signals from the controller to communicate information regarding oxygenator apparatus performance.

Abstract: A dialysis device having an extracorporeal blood circuit which has an arterial line having a blood pump and an arterial needle for connection to a patient, a venous line having a venous needle for connection to a patient and a dialyzer arranged between the arterial line and the venous line and having a blood chamber and a dialysis fluid chamber is provided. The dialysis device furthermore has a control unit and an extracorporeal blood pressure sensor which is arranged at the suction side of the blood pump. The control unit is configured such that a signal output takes place which indicates the presence of recirculation when a change in the signal of the sensor following a trigger event exceeds a threshold value.

Abstract: Methods (300), devices, and systems of processing blood are described. The method (300) comprises the steps of: obtaining (312) blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting (314) bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching (316) concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop.

Abstract: Provided is a blood component separation device and related method, each capable of separating a blood component from blood and rapidly performing a virus inactivation process on the separated blood component. The blood component separation device includes a blood component separation section, provided in a centrifuge, configured to separate a blood component from blood by centrifugation, a diluting section configured to dilute, in a diluent containing riboflavin, concentrated red blood cells separated by the blood component separation section, and a UV light emitting unit configured to perform a virus inactivation process by exposing the concentrated red blood cells thus diluted to the UV light.

Abstract: An infusion system comprises an infusion pump that comprises an input unit and a display unit. The input unit is adapted for adjusting a value of at least one parameter for controlling operation of the infusion pump and/or an infusion process, and the display unit displays the value of the at least one parameter. The input unit comprises at least one slide bar adapted to be touched by a user's finger and moved along its length to change the value of the parameter, wherein movement in a first direction increases the value of the parameter and in a reversed, second direction decreases the value. The slide bar is adapted so that the rate of change of the parameter value correlates with the speed of the finger movement and in an idle mode is decelerated in a similar way as under influence of an inertia load and/or a friction.

Abstract: Devices are provided that include a faceplate for a medical device. In embodiments, an identifier chip adapted to be affixed to an exterior portion of a faceplate provides a unique identifier for the faceplate. Accordingly, the identifier chip enables tracking and monitoring of an associated medical device. And, in embodiments, the faceplate includes a visual communication alert indicator to enable the faceplate to provide visual cues a user. As such, the status of the medical device and the faceplate can be easily communicated to the user. Methods to use the faceplate are also provided.

Abstract: A medical device includes a body and a cannula extending from the body, for insertion into a patient's skin. The medical device also includes a guard covering the cannula, an adhesive for securing the medical device to the patient's skin, and an adhesive liner covering the adhesive. The guard is connected to the adhesive liner to enable conjoint and at least partial removal of the guard and the adhesive liner.

Abstract: Ambulatory infusion pumps, medicament reservoirs, and medicament sealing assemblies, including a variety of trocar seal assemblies and fill plug seal assemblies, plus related components, as well as component combinations and related methods.

Abstract: A digital biomedical device includes a substrate forming a reservoir, a membrane comprising a first layer and a second layer having a strain therebetween, the membrane sealing the reservoir, and a controller configured to activate the membrane and release at least a portion of the strain causing the membrane curl and open the reservoir.

Abstract: A control unit for an electronically controlled pump unit controls the pump unit to infuse insulin into a diabetic's body in a substantially continuous way according to a preset infusion schedule as a function of time. The control unit includes an intervention unit that continuously evaluates a blood-glucose indicative input for detecting an actual or expected hypoglycaemia and executes, in response to an actual or expected hypoglycaemia, a temporary hypoglycaemia intervention. The intervention includes, for an intervention time interval, overriding the preset infusion schedule by temporarily suspending insulin infusion or temporarily reducing insulin infusion below the preset infusion schedule. The intervention unit adapts its way of operation with respect to executing the hypoglycaemia intervention in accordance with a control signal that is separate from the blood-glucose indicative input. The control unit automatically generates the control signal as a function of time and/or based on sensor input.

Abstract: A blood glucose control system is configured to modify therapy provide to a subject and determine whether the modified therapy results in a statistically significant improvement in glycemic control. The system obtains glycemic control information resulting from delivery of first therapy using a first value of a control parameter and determines a first effect corresponding to the first therapy. The control parameter is set to a second value that differs from the first value. The system obtains glycemic control information resulting from the delivery of the second therapy using the second value of the control parameter and determines a second effect corresponding to the second therapy. The system can perform a comparative assessment and determine whether the second value for the control parameter results in a statistically significant improvement in glycemic control for the subject.

Abstract: A liquid medicine injection apparatus capable of injecting an additional fluid after completion of injection of a liquid medicine is provided. The apparatus includes a cylinder elongated in a direction and having a nozzle formed at one end of the cylinder; a piston installed to be hermetically movable within the cylinder in the direction; an injector provided at the other end of the cylinder to allow the piston to be moved; a fluid tank for storing a fluid in a sealed state; a needle unit disposed between the nozzle and the fluid tank; and a cap member provided between the needle unit and the fluid tank and deformable to allow the needle unit to penetrate the fluid tank.