Abstract: Provided are a wearable device for measuring vital signs and a medical support system based on the same, the device comprising: multiple light sources capable of emitting beams having multiple different wavelengths; a photodiode for receiving beams, which are emitted by the multiple light sources and then reflected and scattered by a body portion, and converting the received beams into electrical signals; a BG analyzing module for analyzing electrical signals to obtain the signal amount of a pulse wave type signal corresponding to each of the wavelengths, and calculating the BG level of a subject to be measured, by using a difference signal amount between a pre-input reference value and the signal amount obtained from the body of the subject to be measured; a BP analyzing module for analyzing a pulse wave to distinguish between an incident wave and a reflective wave, detecting the PRT and the pulse pressure, and deriving a BP value through a predetermined calculation procedure; and a communication device capa

Abstract: A compound physiological detection device is configured on a user to detect a plurality of physiological signals of the user. The compound physiological detection device comprises a body. The body comprises an electrocardiography (ECG) sensor for capturing an ECG physiological signal of the user, a photoplethysmography (PPG) sensor for capturing a blood flow change physiological signal of the user, a temperature sensor for capturing a temperature physiological signal of the user, and a sound sensor for capturing a physiological sound physiological signal of the user. The ECG sensor has a reference electrode, and the reference electrode is coupled to a temperature measuring electrode of the temperature sensor.

Abstract: Methods and systems are provided for determining a cardiovascular parameter related to a cardiovascular system of a subject such as the pulse transit time (PTT). An exemplary method may include retrieving a photoplethysmogram (PPG) signal of a subject and determining a plurality of first parameters related to the PPG signal. The method may also include determining a second parameter of the subject. The second parameter may indicate a random effect of the subject. The method may further include determining the cardiovascular parameter based at least on the plurality of first parameters and the second parameter via a trained model.

Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.

Abstract: A system and method for monitoring the blood pressure of a patient that allows for a device sensor to be recalibrated according to atmospheric pressure without removing the device sensor from inside the patient. This permits quickly monitoring the blood pressure of a patient if a re-zero is needed. The invention has a blood pressure monitor (BPM) that obtains an atmospheric pressure observation. The atmospheric pressure observation is adjusted and stored to memory as a zero value. The zero value is retrieved to recalibrate the system and method if a device sensor has been disconnected from and reconnected to the same or a different BPM, the patient has been moved such that the surroundings have been altered to make it necessary to recalibrate according to atmospheric pressure, and/or the device sensor has been connected to a different patient care monitor.

Abstract: Methods of restoring homeostatic capacity of a subject are provided. Aspects of the invention further include compositions, systems and devices for practicing the methods. The methods and compositions described herein find use in a variety of applications.

Abstract: The present disclosure concerns a device for sensing at least one biological parameter (e.g., heart rate, heart rate variability) of a subject, the device comprising a contact surface configured for being brought into a contact with a skin surface of the subject. The device has at least one light source for illuminating the skin surface through the contact surface along an illumination source optical axis with illumination including at least one sensing wavelength, and at least one detector for detecting a response of said illumination at least at said wavelength, from the skin surface through the contact surface along a detector optical axis, and providing signals configured for determining said biological parameter based thereon, said illumination optical axis forming with said contact surface an acute included angle.

Abstract: A system for non-invasively measuring blood volume oscillations inside a cranium of a human subject. The system includes a first light source adapted to be placed on the skin above the cranium of the human subject configured to emit light which penetrates a superficial space outside the cranium. A detector is adapted to be placed on the skin above the cranium of the human subject spaced from the first light source by a first predetermined separation distance that causes the detector to detect light which reflects from the superficial space outside the cranium and output superficial output signals. A second light source is adapted be placed on the skin above the cranium configured to emit light which penetrates through the superficial space outside the cranium to inside the cranium and the detector is spaced from the second light source by a second predetermined separation distance that causes the detector to detect light which reflects from inside the cranium and output cranial output signals.

Abstract: Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has normal or abnormal renal function.

Abstract: A method and system for predicting the likelihood that a patient will suffer from atrial fibrillation is provided. The method includes receiving electrocardiogram data associated with the patient, providing at least a portion of the electrocardiogram data to a trained model, receiving a risk score indicative of the likelihood the patient will suffer from atrial fibrillation within a predetermined period of time from when the electrocardiogram data was generated, and outputting the risk score to at least one of a memory or a display for viewing by a medical practitioner or healthcare administrator. The system includes at least one processor executing instructions to carry out the steps of the method.

Abstract: A system is provided for displaying heart graphic information relating to sources and source locations of a heart disorder to assist in evaluation of the heart disorder. A heart graphic display system provides an intra-cardiogram similarity (“ICS”) graphic and a source location (“SL”) graphic. The ICS graphic includes a grid with the x-axis and y-axis representing patient cycles of a patient cardiogram with the intersections of the patient cycle identifiers indicating similarity between the patient cycles. The SL graphic provides a representation of a heart with source locations indicated. The source locations are identified based on similarity of a patient cycle to library cycles of a library cardiogram of a library of cardiograms.

Abstract: The disclosed apparatus, systems and methods relate to diagnosing Parkinson's disease from electroencephalography (EEG) data. Embodiments herein have practical applications, including diagnosing Parkinson's disease. The methods and systems of the various implementations herein generate a diagnostic index which reflects the probability of the patient having Parkinson's disease. It uses a novel feature extraction method based on Linear Predictive Coding (LPC) which is used to extract Parkinson's disease related features from EEG recordings of the patient and a novel classification method based on Principal Component Analysis (PCA) is used to calculate the diagnostic index from these features.

Abstract: Disclosed is a signal processing system for a brain machine interface (BMI) and a method performed by such a signal processing system. The method involves receiving and filtering input data comprising cortical signal samples, calculating a threshold for detection of spikes, identifying spikes in subsequently received samples, and outputting spike data corresponding to the identified spike or spikes.

Abstract: Systems and methods to determine P wave oversensing (PWOS) are disclosed, including identifying cardiac signal features in received cardiac electrical information, determining a first indication of PWOS using a pattern of identified cardiac signal features, and in response to the determined first indication of PWOS, determining a second indication of PWOS using a morphology of the received cardiac electrical information.

Abstract: A system and method for physiological data classification for use in facilitating diagnosis is provided. A physiological monitor includes a feedback button and physiological data obtained via the physiological monitor is stored in a database. The physiological data is divided into segments and one or more data segments are classified as noise. A determination is made that at least one of the data segments classified as noise includes a marker indicating a press of the feedback button on the physiological monitor. A set of the physiological data including and surrounding the physiological data occurring during the press of the feedback button is identified within the data segment classified as noise. The identified set of physiological data is provided with the data segments classified as valid for analysis.

Abstract: A computer implemented system for automatically recording and generating predictive outputs relating to a medical procedure is described. The system is augmented with biometric sensory data from a biometric sensor coupled to a body of a healthcare practitioner. The biometric sensory data is processed to obtain one or more time-synchronized data objects providing a proxy to an estimated stress level associated with the healthcare practitioner, and the one or more time-synchronized data objects are utilized to identify abnormality-related durations of time encapsulated in the form of time-based metadata tags. The time-based metadata tags are utilized to automatically modify characteristics of the recording or generating of predictive outputs to temporarily consume more computational processing resources during the abnormality-related durations of time.

Abstract: An emergency cardiac and electrocardiogram (ECG) electrode placement device is disclosed herein. The emergency cardiac and electrocardiogram (ECG) electrode placement device incorporates electrical conducting materials and elastic material into a pad that is applied to a chest wall of a patient, which places multiple electrodes in the appropriate anatomic locations on the patient to quickly obtain an ECG in a pre-hospital setting.

Abstract: Systems and methods for resolving catheter rendering issues are provided. A system includes a catheter including a plurality of electrodes and a plurality of catheter pins, each catheter pin corresponding to an associated electrode. The system further includes a mapping system communicatively coupled to the catheter, the mapping system including a pin box including a plurality of sockets, a display device configured to render the catheter, and an electronic control unit (ECU). The ECU is configured to determine that the catheter is being rendered incorrectly on the display device, determine a number of electrodes that are being rendered incorrectly on the display device, identify at least one particular electrode of the plurality of electrodes that is being rendered incorrectly on the display device, and attempt to resolve the incorrect rendering of the catheter based on the determined number of electrodes and the at least one particular electrode.

Abstract: Methods and systems are provided for detecting arrhythmias in cardiac activity. The methods and systems declare a current beat, from the CA signals, to be a candidate beat or an ineligible beat based on whether the current beat satisfies the rate based selection criteria. The determining and declaring operations are repeated for multiple beats to form an ensemble of candidate beats. The method and system calculate a P-wave segment ensemble from the ensemble of candidate beats, perform a morphology-based comparison between the P-wave segment ensemble and at least one of a monophasic or biphasic template, declare a valid P-wave to be present within the CA signals based on the morphology-based comparison, and utilize the valid P-wave in an arrhythmia detection process to determine at least one of an arrhythmia entry, arrhythmia presence or arrhythmia exit.

Abstract: Apparatus, system, and computer readable media determine the probability of visual recognition of an image by a subject using electroencephalography (EEG) corresponding to a Visual Evoked Potential (VEP). The apparatus comprises means for presenting a series of visual stimuli corresponding to said image to evoke EEG signals. The visual stimuli of the image are presented in an orientation sequence based on a timing cycle. At least one prism is provided for placement in front of the series of visual stimuli corresponding to said image. The EEG signals evoked in response to said visual stimuli and said prism placed in front of said visual stimuli are recorded and processed by a processor. VEP is generated corresponding to the presence of a shift and thereby provides object statistic reliability of the visual recognition of the image by the subject.

Abstract: A method for measuring vital signs of an occupant in a vehicle seat is provided. In an embodiment, a sensor includes a transmission circuitry, a reception circuitry, and a controller. The transmission circuitry is configured to transmit a radar beam to an occupant in a vehicle seat. The reception circuitry is configured to receive a reflected signal. The reflected signal being a reflection of the radar beam from the occupant. The controller is configured to determine data associated with a vital sign of the occupant based on the reflected signal.

Abstract: An exemplary system, method and computer-accessible medium for generating a denoised magnetic resonance (MR) image(s) of a portion(s) of a patient(s) can be provided, which can include, for example, generating a plurality of MR images of the portion(s), where a number of the MR images can be based on a number of MR coils in a MR apparatus used to generate the MR images, generating MR imaging information by denoising a first one of the MR images based on another one of the MR images, and generating the denoised MR image(s) based on the MR imaging information. The number of the MR coils can be a subset of a total number of the MR coils in the MR apparatus. The number of the MR coils can be a total number of the MR coils in the MR apparatus. The MR information can be generated by denoising each of the MR images based on the other one of the MR images.

Abstract: The system comprising an internal unit (10) comprising two arrays of N transmitter and N receiver antennas (11R, 11T) for transmitting a microwave signal(s) to one or more body tissues of a patient and for detecting a scattered microwave signal(s) by said one or more body tissues; feeding and multiplexing means (12) in connection with said N transmitter and N receiver antennas (11T, 11R) and with an external computing unit (20) configured to receive said scattered microwave signal(s) and convert it/them into an image, wherein the feeding and multiplexing means (12) provide, under the control of a controller (21) of the external computing unit (20), a continuous sequential selection of different pairs of transmitter and receiver antennas (11T, 11R) to perform the transmission of the microwave signal(s) and the detection of the scattered microwave signal(s).

Abstract: The present disclosure provides systems and methods for detecting and monitoring a patient in need of pressure ulcer treatment based on measurements of Sub-Epidermal Moisture (SEM) values.

Abstract: In one embodiment, a medical device includes an instrument including a distal end configured for inserting into a body part, and a position sensor comprising a flexible printed circuit, which comprises alternating conductive and dielectric layers and is wrapped around the distal end of the instrument, the conductive layers including at least one inner layer, which is patterned with traces forming a coil, and multiple outer layers overlying the at least one inner layer and configured for connection to an electrical ground so as to shield the coil from electromagnetic interference.

Abstract: Disclosed are methods and devices for detecting retained surgical items or other objects having a magnetic signature within a corpus of a patient. The device can comprise a handle, a shaft extending from the handle, and a distal sensing portion positioned distally of the shaft. The distal sensing portion can comprise one or more gradiometers comprising a plurality of magnetometers. The device can further comprise one or more output components configured to generate a user output to alert a user of a detected object.

Abstract: A method for diagnosing one or more diseases of the respiratory tract for a patient including the steps of: acquiring cough sounds from the patient; processing the cough sounds to produce cough sound feature signals representing one or more cough sound features from the cough segments; obtaining one or more disease signatures based on the cough sound feature signals; and classifying the one or more disease signatures to deem the cough segments as indicative of one or more of said diseases; wherein the step of obtaining the one or more disease signatures based on the cough sound feature signals includes applying the cough sound features to each of one or more pre-trained disease signature decision machines, each said decision machine having been pre-trained to classify the cough sound features as corresponding to either a particular disease or to a non-disease state or as corresponding to first particular disease or a second particular disease different from the first particular disease.

Abstract: To perform respiratory monitoring and cardiac-output measurement on general patients, an aspect of a biological measurement apparatus includes: at least two electrodes that are attached to a living body; a power supply that causes an AC current to flow between the two electrodes; at least two coils that are placed so as to sandwich a line linking the two electrodes, and detect a magnetic field related to a change in the AC current accompanying a change in impedance of the living body; and a detection circuit that performs addition or subtraction of signals related to the magnetic field detected with the two coils, and outputs the signals as a change in the impedance.

Abstract: The present invention relates to a device for measuring a person's ventilation. The device includes a conduit with an exhaled-air receiving portion and an inhaled-air receiving portion. The device includes pressure and oxygen sensor sampling ports. The sampling ports are in fluid communication with the conduit. The device includes a deflector disposed within the conduit. The deflector is configured to deflect air exhaled into the exhaled-air receiving portion of the conduit away from the sensor ports.

Abstract: The invention relates to a portable, handheld spirometer (1) comprising a MEMS-based thermal fluid flow sensor (13, 13.1, 13.2) for generating a signal in response to a fluid flow generated during inhalation or exhalation; and a microcontroller (14) for calculating the fluid flow from the signal generated by the flow sensor (13, 13.1, 13.2). The spirometer (1) may be connected to other devices, such as a smartphone or a personal computer or any other computing unit which is adapted to collect, store, analyse, exchange and/or display data. The invention further describes the use of the spirometer (1) in measuring a user's lung performance and/or monitoring it over time.

Abstract: A system for measuring an angle of a joint of a user includes a center hub, a first arm, a second arm, a magnet, and a sensor. The center hub includes a first hub and a second hub. The first arm is configured for attachment to a first limb portion of the user at a first outer end and to the first hub at a first inner end. The second arm is configured for attachment to a second limb portion of the user at a second outer end and to the second hub at a second inner end, wherein the first hub is pivotally coupled to the second hub. The magnet is coupled to the second hub. The sensor is disposed in the center hub and configured to detect a rotation of the magnet.

Abstract: A method of monitoring depth of muscle relaxation of a patient includes applying a series of stimulations to a nerve of a patient and measuring muscle responses thereto. A maximal stimulus current, a supramaximal stimulus current, and/or a submaximal stimulus current are determined based on the muscle responses, wherein the maximal stimulus current is a current at which a maximal muscle response is produced from stimulating the nerve, the supramaximal stimulus current is greater than or equal to the maximal stimulus current, and the submaximal stimulus current is less than the maximal stimulus current. A first set of stimulations are applied to the nerve of the patient. Either the supramaximal stimulus current or the submaximal stimulus current are then selected for a subsequent series of stimulations based on the measured muscle responses to the first series of stimulations, and the subsequent series of stimulations are performed accordingly to monitor the patient's depth of muscle relation.

Abstract: An acceleration acquirer of a controller of an in-bed and out-of-bed determination device acquires, in a time series, acceleration of a subject from a sensor that is an acceleration sensor attached by the subject, a body motion determiner determines, based on the acquired acceleration, whether there is a body motion of the subject at each time, an evaluator evaluates a distribution of the acceleration at a time at which it is determined that there is not a body motion, an estimator estimates a body axis of the subject based on the evaluated distribution of the acceleration, and an in-bed and out-of-bed determiner determines at least one of in bed and out of bed of the subject based on the estimated body axis of the subject that is estimated by the estimator.

Abstract: A camera assembly (3) for use in medical tracking applications, comprising a range camera (4) and a thermographic camera (5) in a fixed relative position.

Abstract: Feature-based joint range of motion (ROM) capture systems and methods can provide increased quality and quantity of data to assess joint ROM without requiring a patient to seek professional assistance or equipment. ROM systems disclosed herein can include a first pattern coupled to a first portion of patient anatomy on a first side of a joint and a second pattern coupled to a second portion of patient anatomy on a second side of the joint opposite the first side. At least one image containing the first and second patterns and the joint can be captured with an image capture device. The first and second patterns can be detected in the at least one image using a feature-based image recognition algorithm. Based on the detected patterns, at least one ROM metric of the associated joint, e.g., a maximum flexion angle, a maximum extension angle, or a range-of-motion, can be calculated.

Abstract: A physiological sensing device for reading an elongated test strip having an insertion end, a test strip width and a test strip length is provided. The physiological sensing device includes a housing, a test strip slot and a first protruding portion. The housing has a front surface, a rear surface opposite to the front surface, and a lateral surface. The test strip slot is disposed on the lateral surface, and having a first slot wall adjacent to the front surface; a second slot wall adjacent to the rear surface, and disposed opposite to the first slot wall; and a slot opening having a slot width, formed between the first slot wall and the second slot wall for accommodating the elongated test strip, and allowing the insertion end to enter the housing through the slot opening.

Abstract: Disclosed herein are systems and methods for providing a compressible interconnect for allowing electrical communication between an electronics unit and an analyte sensor in an on-body analyte monitoring device. In other embodiments, systems and methods are provided for reducing the Z-height of an on-body analyte monitoring device by utilizing novel interconnects.

Abstract: A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode.

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Abstract: An electrochemical system integrated with a cochlear implant to measure a corticosteroid concentration in a cochlear fluid may include a microsensor attached to an electrode array of the cochlear implant. An exemplary microsensor may be configured to be put in contact with a cochlear fluid. An exemplary microsensor may include a working electrode including a carbon microfiber with a diameter of 5 micron to 10 micron, a reference electrode including an Ag/AgCl wire with a diameter of 10 micron to 100 micron, and a counter electrode including a platinum wire with a diameter of 10 micron to 100 micron. An exemplary electrochemical system may further include an electrochemical stimulator/analyzer to measure electrochemical responses from the microsensor, and an array of electrically conductive connectors that may connect an exemplary microsensor to an exemplary electrochemical stimulator/analyzer.

Abstract: A device for sweat analysis includes: (1) a sensing module configured to induce sweat and generate a sensing signal responsive to a sweat concentration of a target analyte in induced sweat, the sensing module including a calibrating sensor to generate a calibration signal responsive to a secretion rate of the induced sweat; and (2) a processor connected to the sensing module, the processor configured to derive a measurement of the sweat concentration of the target analyte from the sensing signal, and to derive a normalized measurement of a blood concentration of the target analyte from the calibration signal.

Abstract: The present invention relates to a detecting device for detecting a blood count parameter in a blood vessel.

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition that includes amounts of one or more immunosuppressant agents so as to provide such membranes with improved material properties such as enhanced biocompatibility.

Abstract: Systems, methods and apparatus are provided for determining an estimate of an analyte level over time. The invention includes sampling sensor data using an analyte sensor positioned at least partially subcutaneously; storing a plurality of datasets of sensor data, each at a different rate; determining an estimated analyte level based on the datasets; and outputting the estimated analyte level to a display. Numerous additional aspects are disclosed.

Abstract: A method for predicting a concentration of an in vivo analyte includes obtaining a plurality of in vivo spectra of the in vivo analyte, determining a learning section for a concentration predicting algorithm for the analyte based on an unchanged section, during which the concentration of the analyte is not substantially changed, and a plurality of the in vivo spectra, and predicting the concentration of the in vivo analyte by using the concentration predicting algorithm based on a learned result of the learning section and an intrinsic spectrum of the in vivo analyte.

Abstract: A surgical elevator has an oximeter sensor at its tip, which allows measuring of oxygen saturation of a tissue.

Abstract: A surgical elevator has an oximeter sensor at its tip, which allows measuring of oxygen saturation of a tissue.

Abstract: Apparatus for optical tissue detection and discrimination between a tissue of a user and non-tissue materials and method of optical tissue detection and discrimination between a tissue of a user and non-tissue materials are provided. The apparatus for optical tissue detection includes one or more of light sources. The apparatus can further include at least one photodetector. A processor can be operable to determine whether the detected light is from a tissue of a user.

Abstract: A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH4+) contained within the bodily fluid into ammonia (NH3) and dispel the converted ammonia (NH3) into a gas sensing chamber. An ammonia (NH3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.

Abstract: An oximeter probe is user configurable for being in an absolute reporting mode and a relative reporting mode for measured values. The measured values for the absolute and relative modes include absolute oxygen saturation, relative oxygen saturation, absolute hemoglobin content, relative hemoglobin content, absolute blood volume, relative blood volume. The relative modes and absolute modes for determining and reporting relative or absolute hemoglobin content or relative or absolute blood volume for individual patients are beneficial when determining the efficacy of administered medications, such as epinephrine, that effect blood flow, but not oxygen saturation, in tissue, such as skin. The oximeter probe in these relative modes displays the efficacy of the administered medication as reported values for relative hemoglobin content or relative blood volume fall or rise.