Abstract: An animated electrophysiology map is generated from a plurality of data points, each including measured electrophysiology information, location information, and timing information. The electrophysiology and location information can be used to generate the electrophysiology map, such as a local activation time, peak-to-peak voltage, or fractionation map. Animated timing markers can be superimposed upon the electrophysiology map using the electrophysiology, location, and timing information. For example a series of frames can be displayed sequentially, each including a static image of the electrophysiology map at a point in time and timing markers corresponding to the state or position of an activation wavefront at the point in time superimposed thereon. The visibility or opacity of the timing markers can be adjusted from frame to frame, dependent upon a distance between the timing marker and the activation wavefront, to give the illusion that the timing markers are moving along the electrophysiology map.

Abstract: In one embodiment, a medical system includes a catheter configured to be inserted into a chamber of a heart of a living subject, and including catheter electrodes configured to contact tissue at respective locations within the chamber of the heart, a display, and processing circuitry configured to receive signals from the catheter, and in response to the signals, sample voltage values of the signals at respective sampling times, compute respective curved three-dimensional surfaces describing electrical activity of the tissue over the catheter electrodes at respective ones of the sampling times, responsively to (a) respective positions of the respective catheter electrodes, and (b) the respective sampled voltage values indicative of electrical activity of the tissue that is sensed by the respective catheter electrodes at the respective locations at the respective sampling times, and render the respective three-dimensional surfaces to the display over time.

Abstract: A catheter includes an elongated body having a longitudinal axis, a distal assembly distal the elongated body, the distal assembly having a tapered helical form comprising a larger, electrode-carrying proximal loop and a smaller, softer distal loop, and a shape-memory support member extending through at least the proximal loop. For example, the helical loop subtends at least about 720 radial degrees, with the proximal loop subtending about 360 radial degrees, and the distal loop subtending about 360 radial degrees. The softer distal loop with a straight distal end atraumatically guides the distal assembly into a tubular region so that the larger proximal loop can sit on the ostium of the tubular region with improved electrode and tissue contact.

Abstract: The invention comprises an EEG electrode assembly for use in attaching an EEG electrode to the scalp of a subject having coarse, curly and/or long hair, or to subjects having their hair in cornrows, braids, and/or dreadlocks. The invention comprises clips for engaging the hair of the subject, the clips being attached to a central portion for holding electrode in contact with the scalp of the subject when the clips are engaged with the hair of the subject.

Abstract: A headpiece, acquisition device, system and method for making electroencephalography (EEG) measurements. The EEG headpiece fits, or adjusts to fit, on a person's scalp, each of a plurality of electrodes is located in the headpiece corresponding to selected respective positions on the scalp, the electrodes are electrically connected to at least one electrical transmitter, and the headpiece is attached to the scalp after the electrodes have been located in the headpiece.

Abstract: Methods for reconstructing images of a subject from data acquired with a medical imaging system, such as a magnetic resonance imaging (“MRI”) system, are described. In general, the image reconstructions implement a primal-dual optimization strategy that, in each iteration, stochastically updates a dual variable.

Abstract: One aspect provides a method of treating a swallowing, mastication, or speech articulation disorder associated with a CNS lesion, PNS lesion, or lesioned brain region in a patient. The method includes: measuring a magnitude and a spatial extent of activation in a plurality of brain regions of the patient during movement of the tongue by functional magnetic resonance imaging (fMRI); generating a map of an individualized network of brain regions that control tongue movement; identifying at least one intact brain region functionally associated with the lesioned brain region based on the map of the individualized network of brain regions; tracking at least one tongue movement of the patient; providing neuronal feedback to the patient based on a level of activation of the at least one intact brain region identified and the at least one tongue movement; and instructing the patient to change at least one motor behavior of the tongue.

Abstract: According to one aspect, an implantable medical device may include an anchor assembly configured to anchor the medical device to a body lumen. The implantable medical device may also include a capsule. The capsule may include a pH sensor. The pH sensor may be configured to measure a pH of contents within the body lumen. The capsule may also include a power source, a controller, and an impedance sensor. The impedance sensor may be configured to measure an impedance within the body lumen.

Abstract: Systems and methods for image-guided medical procedures use fluoroscopic 3D reconstructions to plan and navigate a percutaneously-inserted device such as a biopsy tool from an entry point to a target.

Abstract: A device includes a syringe, which has a tip, plunger, and barrel containing a fluid. The device also includes a needle electrode coupled to the tip of the syringe, a release component, and a control component configured to receive electrical measurements made by the needle electrode, determine impedance values from the electrical measurements, and identify a target tissue based on the impedance values. In response to the identification, the control component generates instructions to reposition a release component. A method includes receiving electrical measurements from a needle electrode, determining impedance values based on the electrical measurements. A target tissue is identified based on the impedance values, and a release component is repositioned in response.

Abstract: A system for collecting cannabis and the psychoactive component tetrahydrocannabinol from a sample of exhaled breath is disclosed. Single or multiple exhaled breaths are conditioned by removing contaminants, and regulating flow rate and/or pressure to collect a sample of tetrahydrocannabinol for timely local or remote analysis. The cannabis detection system comprises a containment trap for removing interfering materials from the breath of the subject and a collection component for sampling components of breath introduced into the system through the containment trap for analysis to determine a presence of THC in the breath.

Abstract: Automated devices provide methodologies for determining sleep conditions, which may be in conjunction with treatment of sleep disordered breathing by a pressure treatment apparatus such as a continuous positive airway pressure device. Based on a measure of respiratory airflow, respiratory characteristics are extracted to detect arousal conditions, sleep stability, sleep states and/or perform sleep quality assessments. The methodologies may be implemented for data analysis by a specific purpose computer, a monitoring device that measures a respiratory airflow and/or a respiratory treatment apparatus that provides a respiratory treatment regime based on the detected conditions.

Abstract: A system includes an interface and a processor. The interface is configured to receive a plurality of electrophysiological (EP) measurements performed in a heart of a patient. The processor is configured to estimate a wall thickness at a specified location of the heart based on the EP measurements.

Abstract: A wearable health device system includes a housing configured to be worn by a subject, and a sensor assembly with at least two accelerometers which sense acceleration along non-parallel axes. A processor operably connected to the sensor assembly and a memory executes program instructions in the memory to obtain SCG template data from the accelerometers and divide the obtained SCG template data into at least one cardiac cycle segment. The cardiac cycle segment is used to generate an SCG acceleration template which is in turn used to generate an SCG rotation matrix. SCG acceleration data is then obtained from the accelerometers and normalized by applying the generated SCG rotation matrix to the obtained SCG acceleration.

Abstract: A bioinformation acquiring apparatus includes at least one processor and a memory configured to store a program to be executed in the processor.

Abstract: A biological state monitoring system (100, 200) for monitoring a biological state of a subject on a bed (BD) includes: at least one load detector (11, 12, 13, 14) configured to detect a load of the subject on the bed; a body motion determining unit (33) configured to determine whether or not the subject has a body motion, based on a temporal variation of a detection value of the load detector; a respiratory rate estimating unit (34) configured to successively obtain and output estimated values of respiratory rate of the subject, based on the temporal variation of the detection value of the load detector; and a twitch determining unit (35) configured to determine whether or not a body motion is a twitch, based on a duration of the body motion of the subject.

Abstract: A mechanism for interpreting spatiotemporal data from augmented and virtual reality devices into fitness related metrics and recommendations. Spatiotemporal data can be compared to the physical data of the end user to interpret energy expense such as estimated calorie burn. A virtual reality or augmented reality device can report positional data over time as the user engages with a corresponding environment. The positional data is compared to a biometric profile of the end user to understand how their physical body is exerting itself. The spatiotemporal data is a series of coordinate data expressed over time. The biometric data is the physical profile of the end user. This data is used to understand and quantify physical movement while using a virtual reality or augmented reality device. The energy expense determination mechanism can be used to provide a virtual coach for activities and workouts, games involving physical movement, and other applications.

Abstract: A computing system obtains motion data describing a movement of an appendage of a patient. Additionally, the computing system determine, based on the motion data, a range of motion of the appendage. Furthermore, the computing system generates, for display by an extended reality visualization device, an extended reality visualization of the range of motion of the appendage superimposed on an image of the patient or an avatar of the patient.

Abstract: A device for recognizing activity of an object. The device comprises a housing configured to be attached to the object and a processing unit disposed in the housing comprising a processor and a movement sensor. The movement sensor measures a signal related to movement of the object during a time window. The processor assigns at least one preliminary activity label to the time window based on at least one numerical descriptor computed from the signal. The processor then determines whether to perform additional analysis dependent upon at least the preliminary activity label. The processor then assigns a final activity label to the time window.

Abstract: A sensor cable support device is described. The sensor cable support device can be used to implemented in wearable monitoring device to support a proximal portion of a sensor cable and electrically connect the proximal portion with a sensing circuitry. A distal portion of the sensor cable is insertable into a person's skin. The sensor cable support device may include a rigid body defining a pair of openings, a set legs attached to the rigid body, and a pair of electrical traces extending between the pair of openings and distal ends of a pair of legs of the set of legs. The pair of openings may be sized and configured to receive a pair of pucks that mechanically retain a sensor cable to the body and electrically connect the sensor cable with the electrical traces.

Abstract: Devices, systems, and methods for providing more accurate and reliable sensor data and for detecting sensor failures. Two or more electrodes can be used to generate data, and the data can be subsequently compared by a processing module. Alternatively, one sensor can be used, and the data processed by two parallel algorithms to provide redundancy. Sensor performance, including sensor failures, can be identified. The user or system can then respond appropriately to the information related to sensor performance or failure.

Abstract: The invention relates to carbon nanotube-containing composites as biosensors to detect the presence of target clinical markers, methods of their preparation and uses in the medical field. The invention is particularly suitable for the detection in patient biological specimens of bone markers and tissue markers. The biosensors of the invention include carbon nanotubes deposited on a substrate, gold nanoparticles deposited on the carbon nanotubes and, binder material and biomolecule deposited on the gold-coated carbon nanotubes. The biomolecule is selected to interact with the target clinical markers. The biosensor can be used as an in-situ or an ex-situ device to detect and measure the presence of the target clinical markers.

Abstract: The present invention relates to a method for managing biometric information and, more specifically, to a method for managing biometric information capable of preventing a use of a sensor module of which an expiration date has expired or a defective sensor module, by determining the validity of a sensor module of a continuous biometric information measuring device on the basis of the generation date of sensor usage information or production lot information received from the continuous biometric information measuring device, and preventing re-use or shared use of the sensor module on the basis of user information provided in a measurement message received from the continuous biometric information measuring device.

Abstract: Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.

Abstract: A system and method for contactless blood pressure determination. The method includes: receiving a captured image sequence; determining, using a trained hemoglobin concentration (HC) changes machine learning model, bit values from a set of bitplanes in the captured image sequence that represent the HC changes of the subject; determining a blood flow data signal; extracting one or more domain knowledge signals associated with the determination of blood pressure; building a trained blood pressure machine learning model with a blood pressure training set, the blood pressure training set including the blood flow data signal of the one or more predetermined ROIs and the one or more domain knowledge signals; determining, using the blood pressure machine learning model trained with a blood pressure training set, an estimation of blood pressure; and outputting the determination of blood pressure.

Abstract: An optical measurement device includes a light source, a first detector, and a second detector. The light source emits light to a measurement site of a patient and one or more detectors detect the light from the light source. At least a portion of a detector is translucent and the light passes through the translucent portion prior to reaching the measurement site. A detector receives the light after attenuation and/or reflection or refraction by the measurement site. A processor determines a light intensity of the light source, a light intensity through a tissue site, or a light intensity of reflected or refracted light based on light detected by the one or more detectors. The processor can estimate a concentration of an analyte at the measurement site or an absorption or reflection at the measurement site.

Abstract: A biometric measurement apparatus includes a light source that emits light onto a head portion of a user, an image sensor, a controller that controls the light source and the image sensor, and a signal processor. The controller causes the light source to emit the light and causes the image sensor to output an image signal by causing the image sensor to detect at least part of reflected light returning from the head portion in response to emission of the light. The signal processor generates brain activity data indicating a state of a brain of the user and stops outputting the brain activity data based on at least one selected from the group consisting of the image signal and a sensor signal output from a sensor that detects a change, affecting the brain activity data, in an environment surrounding the user.

Abstract: A syringe assembly includes (i) a syringe with a cylindrical body, luer tip at a first end, finger grip at a second end and a cannula extending from the luer tip into the cylindrical body, and (ii) a plunger unit having an adapter portion, receiving cavity, finger grip and piston. A channel extends the length of the adapter portion to receive the cannula in one end and a variety of connectors, valves and/or syringes in a second end. The end of the channel accessible in the receiving cavity mates with or engages any number of commercially available valves, connectors and/or syringes while the luer tip similarly connects to any number of valves, catheters, connectors, etc., depending on the task being undertaken with the syringe assembly.

Abstract: A biological fluid collection device that allows a blood sample to be collected anaerobically is disclosed.

Abstract: The fatigue degree estimation device includes: an R-wave detection unit that detects an R-wave from an electrocardiogram waveform of a subject; an R-R interval calculation unit that calculates an R-R interval which is a time interval between the R-wave detected by the R-wave detection unit and an immediately preceding R-wave; a difference calculation unit that calculates a difference between the R-R intervals away from each other by a certain heart rate; a percentage calculation unit that calculates a percentage of an absolute value of the difference between the R-R intervals exceeding a certain value in a target period of fatigue degree estimation; and a fatigue degree estimation unit that estimates a fatigue degree of the subject based on the percentage.

Abstract: The present disclosure provides a wearable device, which includes: a frame adapted to be worn on a body part of a user. The frame includes: one or more sensors configured in a housing and operative to sense one or more parameters associated with the body of the user to generate one or more signals indicative of the one or more sensed parameters when the wearable device is worn; a processor configured in the housing and operatively coupled with the one or more sensors, the processor operative to analyze the one or more signals to extract one or more attributes associated with the user from the one or more signals, wherein the one or more attributes being indicative of emotional states of the user; and a display device configured at a portion of the housing and operatively coupled with the processor, wherein the display device is configured to indicate, based on the extracted one or more attributes of the user, the emotional states of the user.

Abstract: The disclosure provides a brainwave headband structure, which includes a body and a brainwave detection module, wherein the body is provided with an inner surface and an outer surface. The brainwave detection module is arranged on the outer surface of the body and is electrically connected with a first electrode, a second electrode and a third electrode. The first electrode is arranged on the inner surface of the body, and the second electrode and the third electrode are oppositely arranged at two sides of the body in a manner of simultaneously covering a part of the inner surface and a part of the outer surface. When a user wears the body on a head, the first electrode is in contact with a forehead of the user, and the second electrode and the third electrode are in contact with ears of the user or peripheral regions near the ears.

Abstract: The present disclosure provides systems and methods for seizure detection. The method for seizure detection may include receiving a plurality of electroencephalography (EEG) signals over a plurality of channels for a subject, preprocessing the plurality of EEG signals by segmenting the plurality of EEG signals for each channel into a plurality of temporal data segments, extracting a plurality of features from each temporal data segment for each channel, and applying a machine learning algorithm to the plurality of features to perform a seizure binary classification for each temporal data segment for each channel. A control policy may be employed to determine a seizure burden on the aggregated seizure binary classifications. When the seizure burden is equal to or exceeds a threshold, a notification may be generated. The notification may be usable by a healthcare practitioner to assess whether the subject may be at risk of having a seizure.

Abstract: A system for calculating an indicator associated to a brain activity of a subject, the system including an acquisition module configured to acquire at least an epoch of electroencephalographic signal of a subject from a plurality of electrodes and a data processing module configured to carry out the steps of: calculating an average vector (VA) using as input of an autoencoder neural network (aNN) an electroencephalographic signals (ES) of a subject acquired from a plurality of electrodes; detecting (DET) the presence of at least a predefined pattern in the consecutive average values of the average vector (VA); and generating an indicator of brain activity (Idx) of the subject when detecting the predefined pattern.

Abstract: Disclosed is a sensor that includes a first textile assembly having a first conductive textile element and a first outer sheath that surrounds the first conductive textile element. The first outer sheath is formed from a first non-conductive material that is configured to transport moisture through the first outer sheath. The sensor includes a second textile assembly having a second conductive textile element and a second outer sheath that surrounds the second conductive textile element. The second outer sheath is formed from a second non-conductive material that is configured to transport moisture through the second outer sheath. The first and second outer sheaths are in contact with each other so as to maintain separation between the first conductive textile element and the second conductive textile element along a length of the sensor.

Abstract: A method, system and computer readable storage media for defects in images during three-dimensional measurement of teeth. An operator may use a dental camera to scan teeth and a trained deep neural network may automatically detect portions of the input images having defects and generate output information regarding those defects for corrective measures to be taken.

Abstract: A tool for distress management. The tool determines a level of distress associated with a user. The tool identifies a next action to be performed by the user. The tool determines a level of distress associated with the next action. The tool determines whether the associated level of distress exceeds a predetermined threshold. Responsive to a determination that the associated level of distress exceeds the predetermined threshold, the tool alerts the user of an impact to the level of distress associated with the user.

Abstract: This disclosure is directed to method and system for automatic, distributed, computer-aided, and intelligent data collection/analytics, health monitoring, health condition identification, and patient preventive/remedial health advocacy.

Abstract: A cyclic alternative pattern (CAP) detection device includes a memory storing a program, and at least one processor configured to execute the program stored in the memory, in which the processor is configured to: acquire pulse wave data of a subject; derive a baseline of the pulse wave data and an envelope of the baseline; identify a local maximum point of the envelope and determine, as CAP candidate points each indicating a cyclic alternative pattern, a first local maximum point of the baseline before the local maximum point of the envelope and a second local maximum point of the baseline after the local maximum point of the envelope on a time axis; and identify, for each of the identified CAP candidate points, a third local maximum point of the baseline before the CAP candidate point and a local minimum point of the baseline between the CAP candidate point and the third local maximum point and detect the CAP candidate point as a CAP based on an evaluation value obtained from a difference between the CAP can

Abstract: A non-invasive method and system are provided for determining a sleep stage of a subject. The method includes obtaining one or more respiratory signals, the one or more respiratory signals being an indicator of a respiratory activity of the subject, extracting features from the one or more respiratory signals, and determining a sleep stage of the subject based on the extracted features.

Abstract: Various methods and machines have been used in the past to measure electrical characteristics of living tissue for purpose of locating an area of abnormal nervous system activity. However, whereas prior art methodologies merely allow for the detection of pain, the apparatus, system and method of the present invention allow for the objective assessment of autonomic nerve function and/or pain severity. As such, the present invention finds utility not only the initial diagnosis, including the early diagnosis of generally asymptomatic autonomic dysfunction, but also the on-going treatment of any disease, disorder or injury associated therewith. To that end, the apparatus, system and method of the present invention allows medical practitioners to non-invasively and quantitatively distinguish the organic from the psychosomatic and legitimate pain patients from drug seekers and opioid addicts, as well as to directly and objectively compare the efficacy of different drug regimens and therapy protocols.

Abstract: An articulation rigidity assessment device comprises a single-axis angular velocity sensor attachable to a limb such that an axis of measurement is parallel to a predetermined rotation axis of a bending motion imposed during a dosage administration regime of a drug in order to identify a clinically effective dose as having been administered. A data processor is configured to process an angular velocity sensor signal during the dosage administration, calculate a non-rigidity index of the articulation using the processed signal, wherein the non-rigidity index is the square root of the multiplication of the average of the angular velocity signal by the average peak value of the angular velocity signal. The device outputs feedback of the non-rigidity index at a current dose of the drug, whereby the clinically effective dose is identified as having been administered as a function of the output. A method is also disclosed.

Abstract: A wearable electronic device including a housing that is worn by a user and a SMI sensor contained within the housing. The SMI sensor may include an emitter that outputs coherent light toward the skin of a user when the housing is worn by the user. The SMI sensor may also include a detector that detects a portion of the coherent light reflected towards the sensor and generates electrical signals that indicate displacements of the skin based on the portion of coherent light received at the detector. The housing may include a transmitter that is operatively coupled with the SMI sensor and is configured to transmit physiological data to a receiving device based on electrical signals output from the SMI sensor.

Abstract: An apparatus for estimating biometric information is provided. According to one exemplary embodiment, the apparatus may include a sensor comprising an electrocardiogram (ECG) sensor configured to measure an ECG signal of a user and a pulse wave sensor configured to measure two or more pulse wave signals at two or more measurement sites of the user; and a processor configured to obtain biometric information based on the ECG signal and the two or more pulse wave signals measured by the sensor.

Abstract: Some embodiments are directed to a self-contained breathing mask for measuring and monitoring the breath of a human subject. The mask may be lightweight, self-contained, and physically untethered to any test or measurement equipment, providing the subject full mobility, and allowing him/her to perform almost any daily activity during use. The mask may include integrated sensors for measuring properties of the subject's breath, over any length of time, providing respiratory information like breath count, rate and volume, oxygen consumption, and carbon dioxide production, as well as various biometric information.

Abstract: A sensor garment for monitoring an individual engaged in an athletic activity includes a garment formed of textile material, and a sensor module inseparably coupled to the textile material of the garment. The sensor module includes a single-purpose sensor configured to sense a single characteristic, and a radio antenna configured to transmit data generated by the single-purpose sensor. The sensor module includes no external port.

Abstract: A wearable health device system includes a housing configured to be worn by a subject, and a sensor assembly with at least two accelerometers which sense acceleration along non-parallel axes. A processor operably connected to the sensor assembly and a memory executes program instructions in the memory to obtain SCG template data from the accelerometers and divide the obtained SCG template data into at least one cardiac cycle segment by converting the SCG template data into polar coordinate SCG template data or spherical coordinate SCG template data. At least one reference cardiac event is identified in the SCG template data using the converted SCG template data, and the SCG template data is divided into at least one cardiac cycle segment based upon the referenced cardiac event.

Abstract: A signal measurement apparatus and signal measurement method are provided. The signal measurement apparatus includes an amplifier configured to receive a differential voltage signal, amplify the received differential voltage signal, and output the amplified differential voltage signal, a controller configured to output a control signal to control a switching circuit in response to a signal value of the amplified differential voltage signal satisfying a condition, and wherein the switching circuit is configured to change connections between input terminals of the amplifier and paths along which the differential voltage signal is transmitted, based on the control signal.

Abstract: A sensor belt may include a flexible substrate comprising a first portion arranged to face a wearer and a second portion arranged to face away from the wearer. At least one sensor may be disposed on the first portion of the flexible substrate. An electronics unit may be disposed on the second portion of the flexible substrate and electrically coupled to the at least one sensor. The first portion of the flexible substrate may be configured to flex independently of the second portion of the flexible substrate in some embodiments. The first portion of the flexible substrate and the second portion of the flexible substrate may define a channel in some embodiments.

Abstract: A multi-lumen catheter for monitoring uterine contraction pressure having an elongated body configured and dimensioned for insertion into a bladder of a patient, the catheter having a first lumen, a second lumen, and a first balloon at a distal portion, the first lumen communicating with the first balloon. The second lumen communicates with the bladder to remove fluid from the bladder. The first balloon is filled with a gas to form along with the first lumen a gas filled chamber to monitor pressure within the bladder to thereby monitor uterine contraction pressure of the patient.